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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOD3 Gene

protein-coding   GIFtS: 64
GCID: GC04P024798

Superoxide Dismutase 3, Extracellular

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Superoxide Dismutase 3, Extracellular1 2
EC-SOD2 3
EC 1.15.1.13 8
Extracellular Superoxide Dismutase [Cu-Zn]2

External Ids:    HGNC: 111811   Entrez Gene: 66492   Ensembl: ENSG000001096107   OMIM: 1854905   UniProtKB: P082943   

Export aliases for SOD3 gene to outside databases

Previous GC identifers: GC04P024921 GC04P024484 GC04P024546 GC04P024472 GC04P024139


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOD3 Gene:
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that
catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene
is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the
extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and
cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is
cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SOD3 Gene: 
SOD3 (superoxide dismutase 3, extracellular) is a protein-coding gene. Diseases associated with SOD3 include keratopathy, and usual interstitial pneumonia. GO annotations related to this gene include heparin binding and superoxide dismutase activity. An important paralog of this gene is SOD1.

UniProtKB/Swiss-Prot: SODE_HUMAN, P08294
Function: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting
superoxide radicals into hydrogen peroxide and oxygen

Gene Wiki entry for SOD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOD3 gene promoter:
         STAT5B   SRF   SRF (504 AA)   Nkx5-1   E47   Gfi-1   RORalpha1   POU2F1   POU2F1a   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SOD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.2

SOD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOD3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P024798:  view genomic region     (about GC identifiers)

Start:
24,791,534 bp from pter      End:
24,802,467 bp from pter
Size:
10,934 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SODE_HUMAN, P08294 (See protein sequence)
Recommended Name: Extracellular superoxide dismutase [Cu-Zn] precursor  
Size: 240 amino acids; 25851 Da
Cofactor: Binds 1 copper ion per subunit (By similarity)
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homotetramer
Subcellular location: Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate
proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma
and the endothelium
1 PDB 3D structure from and Proteopedia for SOD3:
2JLP (3D)    
Secondary accessions: Q5U781 Q6FHA2

Explore the universe of human proteins at neXtProt for SOD3: NX_P08294

Explore proteomics data for SOD3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08294

  • 3 DME Specific Peptides for SOD3 (P08294)
     GRAVVVH  HVHQFGD  RLACCVVG 

    SOD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SOD3 Protein Expression
    REFSEQ proteins: NP_003093.2  
    ENSEMBL proteins: 
     ENSP00000472134   ENSP00000371554  

    Human Recombinant Protein Products for SOD3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SOD3
    OriGene Protein Over-expression Lysate for SOD3
    OriGene MassSpec for SOD3 
    OriGene Custom Protein Services for SOD3
    GenScript Custom Purified and Recombinant Proteins Services for SOD3
    Novus Biologicals SOD3 Protein
    Novus Biologicals SOD3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOD3 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IBA--
    GO:0005802trans-Golgi network IEA--

    SOD3 for ontologies           About GeneDecksing



    SOD3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SOD3
    R&D Systems Antibodies for SOD3 (SOD3/EC-SOD)
    OriGene Antibodies for SOD3
    OriGene Custom Antibody Services for SOD3
    GenScript Custom Superior Antibodies Services for SOD3
    Novus Biologicals SOD3 Antibodies
    Abcam antibodies for SOD3
    Cloud-Clone Corp. Antibodies for SOD3 
    ThermoFisher Antibodies for SOD3
    LSBio Antibodies in human, mouse, rat for SOD3 

    Assay Products for SOD3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SOD3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SOD3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOD3 
    Cloud-Clone Corp. CLIAs for SOD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR018152 SOD_Cu/Zn_BS
     IPR001424 SOD_Cu_Zn_dom
     IPR024141 SOD_Cu/Zn_extracel
     IPR024134 SOD_Cu/Zn_/chaperones

    Graphical View of Domain Structure for InterPro Entry P08294

    ProtoNet protein and cluster: P08294

    UniProtKB/Swiss-Prot: SODE_HUMAN, P08294
    Similarity: Belongs to the Cu-Zn superoxide dismutase family


    SOD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SODE_HUMAN, P08294
    Function: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting
    superoxide radicals into hydrogen peroxide and oxygen
    Catalytic activity: 2 superoxide + 2 H(+) = O(2) + H(2)O(2)

         Genatlas biochemistry entry for SOD3:
    superoxide dismutase 3,extracellular,predominantly expressed in heart,placenta,pancreas,lung,catabolic pathway of
    activated oxygen species,free radical detoxification

         Enzyme Number (IUBMB): EC 1.15.1.11 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004784superoxide dismutase activity IBA--
    GO:0005507copper ion binding IBA--
    GO:0005515protein binding IPI15528465
    GO:0008201heparin binding IEA--
    GO:0008270zinc ion binding IBA--
         
    SOD3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SOD3:
     Actin fiber cells 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sod3):
     homeostasis/metabolism  immune system  mortality/aging  normal  skeleton 

    SOD3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sod3tm1Mrkl for SOD3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SOD3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SOD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOD3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOD3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOD3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SOD3:
    hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidSOD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SOD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOD3

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SOD3

    Clone
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    GenScript: all cDNA clones in your preferred vector: SOD3 (NM_003102)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOD3
    Sirion Biotech Customized lentivirus for stable overexpression of SOD3 
                         Customized lentivirus expression plasmids for stable overexpression of SOD3 

    Cell Line
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    Search LifeMap BioReagents cell lines for SOD3
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SOD3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selenium Pathway
    Selenium Pathway
    2Selected targets of C/EBPbeta
    Selected targets of C/EBPbeta
    3Oxidative Stress
    Oxidative Stress
    4Folate Metabolism
    Folate Metabolism
    5superoxide radicals degradation
    superoxide radicals degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SOD3
        Selected targets of C/EBPbeta


    4 BioSystems Pathways for SOD3
        Oxidative Stress
    Selenium Pathway
    Folate Metabolism
    superoxide radicals degradation



    SOD3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SOD3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SOD3 (P082943 ENSP000003715544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBLN5Q9UBX53, ENSP000003450084I2D: score=1 STRING: ENSP00000345008
    CATENSP000002410524STRING: ENSP00000241052
    TYRP1ENSP000003735704STRING: ENSP00000373570
    SOD2ENSP000003371274STRING: ENSP00000337127
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006801superoxide metabolic process ----
    GO:0006950response to stress ----
    GO:0019430removal of superoxide radicals IBA--
    GO:0046688response to copper ion IEA--

    SOD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SOD3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOD3 (SODE)

    7 HMDB Compounds for SOD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    OxygenOxygen (see all 5)7782-44-7--
    Superoxidedioxidanidyl (see all 7)11062-77-4--
    ZincZinc (see all 2)7440-66-6--

    10/48 Novoseek inferred chemical compound relationships for SOD3 gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    superoxide 89 656 16087389 (5), 16443677 (5), 8743981 (5), 17717013 (4) (see all 99)
    heparin 64.2 119 8864862 (5), 19754153 (5), 15362977 (4), 8452552 (4) (see all 42)
    heparan sulfate 62.3 25 16973718 (3), 12736188 (1), 9464851 (1), 15362977 (1) (see all 12)
    manganese superoxide 61.1 10 15362370 (1), 18094428 (1), 15755737 (1), 19477268 (1) (see all 7)
    oxygen 52.3 26 16471171 (2), 10811593 (1), 18203633 (1), 12406846 (1) (see all 18)
    peroxynitrite 50.3 5 9484979 (2), 7583586 (1), 16840738 (1)
    nitric oxide 47.9 93 10841522 (7), 11566193 (5), 10712391 (4), 16214176 (4) (see all 26)
    alpha-phenyl-n-tert-butylnitrone 46.4 1 16816350 (1)
    pyrogallol 44 4 2079230 (1), 12495809 (1), 8135741 (1)
    h2o2 40.9 10 18971527 (1), 12600029 (1), 17242675 (1), 15280800 (1)

    Search CenterWatch for drugs/clinical trials and news about SOD3 / SODE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SOD3 gene: 
    NM_003102.2  

    Unigene Cluster for SOD3:

    Superoxide dismutase 3, extracellular
    Hs.2420  [show with all ESTs]
    Unigene Representative Sequence: BM906283
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000598411 ENST00000593742 ENST00000382120(uc003gqz.3)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SOD3:
    hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidSOD3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene ORF clones in mouse, rat for SOD3
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    GenScript: all cDNA clones in your preferred vector: SOD3 (NM_003102)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOD3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOD3

    Additional mRNA sequence: 

    AK313935.1 BC014418.1 CR541853.1 J02947.1 

    4 DOTS entries:

    DT.212315  DT.100723316  DT.100795871  DT.100795866 

    24/208 AceView cDNA sequences (see all 208):

    CR607978 CR622278 BM723136 BM709341 T28376 AI669737 CR608025 CR592129 
    CR595031 CR606896 AA364831 CR618426 CR597150 CR625060 BF724293 BM709101 
    AL550101 BM702290 BI820221 BI488958 BQ181488 CA394112 CD518765 BI762405 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOD3 expression in normal human tissues (normalized intensities)      SOD3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCGGCGGG
    SOD3 Expression
    About this image


    SOD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
             brain/hindbrain   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Normal Human Articular chondrocytes (NHAC)   
     
     Dermis (Uncategorized)    fully expand to see all 2 entries
             BH2 Dermal Fibroblasts   
     
     Smooth Muscle (Muscoskeletal System)
             Coronary Artery Smooth Muscle Cells (CASMC)   

    See SOD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SOD3

    SOURCE GeneReport for Unigene cluster: Hs.2420

    UniProtKB/Swiss-Prot: SODE_HUMAN, P08294
    Tissue specificity: Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in
    extracellular fluids such as plasma, lymph and synovial fluid

        SABiosciences Expression via Pathway-Focused PCR Arrays including SOD3: 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Cellular Stress Responses in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SOD3 gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sod31 , 5 superoxide dismutase 3, extracellular1, 5 74.61(n)1
    68.09(a)1
      5 (27.92 cM)5
    206571  NM_011435.31  NP_035565.11 
     523638045 
    chicken
    (Gallus gallus)
    Aves SOD31 superoxide dismutase 3, extracellular 56.71(n)
    52.81(a)
      422810  XM_420760.3  XP_420760.3 
    lizard
    (Anolis carolinensis)
    Reptilia SOD36
    Superoxide dismutase [Cu-Zn]
    45(a)
    1 ↔ 1
    5(73296826-73297548)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ085212.12   -- 67.28(n)    BJ085212.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sod3b1 superoxide dismutase 3, extracellular b 55.56(n)
    55.13(a)
      794006  XM_001332722.4  XP_001332758.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sod6
    Sod36
    Superoxide dismutase 3
    32(a)
    26(a)
    possible ortholog
    1 ↔ 1
    3L(11105381-11106840)
    2R(7267849-7271613)
    worm
    (Caenorhabditis elegans)
    Secernentea sod-16
    sod-56
    (see all 3)
    Protein SOD-5
    (see all 3)
    31(a)
    28(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    II(6972712-6973892)
    II(4417683-4419131)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SOD16
    Cytosolic copper-zinc superoxide dismutase; some m...
    37(a)
    1 → many
    X(622550-623014)


    ENSEMBL Gene Tree for SOD3 (if available)
    TreeFam Gene Tree for SOD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOD3 gene
    SOD12  CCS2  
    1 SIMAP similar gene for SOD3 using alignment to 2 protein entries:     SODE_HUMAN (see all proteins):
    SOD1

    SOD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: SODE_HUMAN, P08294
    Polymorphism: The variant Gly-231 which is found in about 2.2% of individual displays a 10-fold increased plasma
    EC-SOD content due to reduced heparin-binding affinity and thus the impairment of its binding ability to
    endothelial cell surface


    10/210 SNPs in SOD3 are shown (see all 210)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17998951,2,4
    C,Fpathogenic124742159(+) AGAAGC/GGGCGG 2 R G mis1 ese37Minor allele frequency- G:0.05NS MN NA 570
    rs1872071601,2
    --24735431(+) CACATG/TCGTAT 1 -- us2k10--------
    rs1898910881,2
    --24735434(+) ATGCGA/TATACC 1 -- us2k10--------
    rs178796781,2
    C,F--24735481(+) CCTTCT/CGCATT 1 -- us2k13Minor allele frequency- C:0.01NS NA 184
    rs1872543631,2
    --24735552(+) TTTTTC/TCTCCA 1 -- us2k10--------
    rs415326491,2
    C,F--24735784(+) TGTTAC/TCAAAG 1 -- us2k12Minor allele frequency- T:0.03NA WA 164
    rs133067031,2
    C,F--24735836(+) GGTGGC/TGAGAA 1 -- us2k116Minor allele frequency- T:0.18NS NA WA CSA EA 1322
    rs1901619531,2
    --24735917(+) ACCAGA/CACGGA 1 -- us2k10--------
    rs178810811,2
    C,F--24735919(+) CAGAAC/TGGAGA 1 -- us2k11Minor allele frequency- T:0.01NS 166
    rs178859211,2
    C,F--24735926(+) GAGACG/ATGCTT 1 -- us2k13Minor allele frequency- A:0.03NS NA WA 332

    HapMap Linkage Disequilibrium report for SOD3 (24791534 - 24802467 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SOD3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829887CNV Gain+Loss17160897


    Human Gene Mutation Database (HGMD): SOD3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SOD3
    DNA2.0 Custom Variant and Variant Library Synthesis for SOD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 185490    OMIM disorders: --

    20/71 diseases for SOD3 (see all 71):    About MalaCards
    keratopathy    usual interstitial pneumonia    bullous keratopathy    coronary stenosis
    adult respiratory distress syndrome    diabetic polyneuropathy    asbestosis    diabetic neuropathy
    myocardial stunning    hyperhomocysteinemia    keratoconus    optic neuritis
    neuritis    pulmonary fibrosis    cerebrovascular disease    ischemic heart disease
    homocystinuria    bronchopulmonary dysplasia    polyneuropathy    pneumonia

    2 diseases from the University of Copenhagen DISEASES database for SOD3:
    Vascular disease     Pulmonary fibrosis

    SOD3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/37 Novoseek inferred disease relationships for SOD3 gene (see all 37)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pulmonary fibrosis 34.5 9 17999630 (3), 18165226 (1), 19073610 (1), 16224105 (1)
    bullous keratopathy 34.3 2 17679946 (2)
    atherosclerosis 32.4 16 16191429 (2), 15329502 (2), 9484979 (1), 18726685 (1) (see all 11)
    lung diseases 29.5 4 10194479 (1), 9184535 (1), 19465032 (1)
    keratoconus 28.3 5 17679946 (5)
    coronary artery disease 27.8 14 16191429 (1), 17644511 (1), 9848884 (1), 15329502 (1) (see all 6)
    pulmonary disease chronic obstructive 26.6 2 18703790 (1), 18948423 (1)
    cardiovascular diseases 26.4 3 11350569 (1), 15451065 (1)
    zinc deficiency 18.6 2 11437176 (1), 10383098 (1)
    cerebral vasospasm 17.3 4 12574556 (2), 15472087 (2)

    Genetic Association Database (GAD): SOD3
    Human Genome Epidemiology (HuGE) Navigator: SOD3 (53 documents)

    Export disorders for SOD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOD3 gene, integrated from 9 sources (see all 353):
    (articles sorted by number of sources associating them with SOD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An arginine-213 to glycine mutation in human extracellular-superoxide dismutase reduces susceptibility to trypsin-like proteinases. (PubMed id 8864862)1, 2, 9 Adachi T....Hirano K. (1996)
    2. Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. (PubMed id 18948423)1, 4, 9 Arcaroli J.J....Crapo J.D. (2009)
    3. Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene. (PubMed id 7959763)1, 2, 9 Folz R.J. and Crapo J.D. (1994)
    4. 10-fold increase in human plasma extracellular superoxide dismutase content caused by a mutation in heparin-binding domain. (PubMed id 8034674)1, 2, 9 Sandstrom J.... Marklund S.L. (1994)
    5. The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro. (PubMed id 1505778)1, 2, 9 Adachi T.... Marklund S.L. (1992)
    6. The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding. (PubMed id 19289127)1, 2, 9 Antonyuk S.V.... Hasnain S.S. (2009)
    7. Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (PubMed id 19108943)1, 4, 9 Rosta K....VAcr A. (2009)
    8. Multiplex single base extension method for simultaneous genotyping of non-synonymous SNP in the three human SOD genes. (PubMed id 19016244)1, 4, 9 Iida R....Yasuda T. (2008)
    9. Polymorphic variants of extracellular superoxide dismutase gene in a Romanian population with atheroma. (PubMed id 18726685)1, 4, 9 Samoila O.C....Seclaman E. (2008)
    10. Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study. (PubMed id 17646272)1, 4, 9 Kang D....Hayes R.B. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6649 HGNC: 11181 AceView: SOD3 Ensembl:ENSG00000109610 euGenes: HUgn6649
    ECgene: SOD3 H-InvDB: SOD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOD3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/sod3/
    Wikipedia http://en.wikipedia.org/wiki/Superoxide_dismutase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SOD3 gene:
    Search GeneIP for patents involving SOD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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