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SOD3 Gene

protein-coding   GIFtS: 66
GCID: GC04P024798

Superoxide Dismutase 3, Extracellular

  See SOD3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Superoxide Dismutase 3, Extracellular1 2
EC-SOD2 3
EC 1.15.1.13 8
Extracellular Superoxide Dismutase [Cu-Zn]2

External Ids:    HGNC: 111811   Entrez Gene: 66492   Ensembl: ENSG000001096107   OMIM: 1854905   UniProtKB: P082943   

Export aliases for SOD3 gene to outside databases

Previous GC identifers: GC04P024921 GC04P024484 GC04P024546 GC04P024472 GC04P024139


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOD3 Gene:
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that
catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene
is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the
extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and
cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is
cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SOD3 Gene:
SOD3 (superoxide dismutase 3, extracellular) is a protein-coding gene. Diseases associated with SOD3 include keratopathy, and coronary stenosis. GO annotations related to this gene include heparin binding and superoxide dismutase activity. An important paralog of this gene is SOD1.

UniProtKB/Swiss-Prot: SODE_HUMAN, P08294
Function: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting
superoxide radicals into hydrogen peroxide and oxygen

Gene Wiki entry for SOD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_006316.17  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOD3 gene promoter:
         STAT5B   SRF   SRF (504 AA)   Nkx5-1   E47   Gfi-1   RORalpha1   POU2F1   POU2F1a   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SOD3 promoter sequence
   Search Chromatin IP Primers for SOD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.2

SOD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOD3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P024798:  view genomic region     (about GC identifiers)

Start:
24,791,534 bp from pter      End:
24,802,467 bp from pter
Size:
10,934 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SODE_HUMAN, P08294 (See protein sequence)
Recommended Name: Extracellular superoxide dismutase [Cu-Zn] precursor  
Size: 240 amino acids; 25851 Da
Cofactor: Binds 1 copper ion per subunit (By similarity)
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homotetramer
1 PDB 3D structure from and Proteopedia for SOD3:
2JLP (3D)    
Secondary accessions: Q5U781 Q6FHA2

Explore the universe of human proteins at neXtProt for SOD3: NX_P08294

Explore proteomics data for SOD3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn107, Lys229, Lys230
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for SOD3 (P08294)
     GRAVVVH  HVHQFGD  RLACCVVG 


    See SOD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003093.2  
    ENSEMBL proteins: 
     ENSP00000472134   ENSP00000371554  
    Reactome Protein details: P08294

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    Cloud-Clone Corp. Proteins for SOD3

     
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    SOD3 Antibody Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOD3
    Cloud-Clone Corp. CLIAs for SOD3
    Search eBioscience for ELISAs for SOD3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR018152 SOD_Cu/Zn_BS
     IPR001424 SOD_Cu_Zn_dom
     IPR024141 SOD_Cu/Zn_extracel
     IPR024134 SOD_Cu/Zn_/chaperone

    Graphical View of Domain Structure for InterPro Entry P08294

    ProtoNet protein and cluster: P08294

    UniProtKB/Swiss-Prot: SODE_HUMAN, P08294
    Similarity: Belongs to the Cu-Zn superoxide dismutase family


    Find genes that share domains with SOD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SODE_HUMAN, P08294
    Function: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting
    superoxide radicals into hydrogen peroxide and oxygen
    Catalytic activity: 2 superoxide + 2 H(+) = O(2) + H(2)O(2)

         Genatlas biochemistry entry for SOD3:
    superoxide dismutase 3,extracellular,predominantly expressed in heart,placenta,pancreas,lung,catabolic pathway of
    activated oxygen species,free radical detoxification

         Enzyme Number (IUBMB): EC 1.15.1.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004784superoxide dismutase activity TAS--
    GO:0005507copper ion binding IBA--
    GO:0005515protein binding IPI15528465
    GO:0008201heparin binding IEA--
    GO:0008270zinc ion binding IBA--
         
    Find genes that share ontologies with SOD3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SOD3:
     Actin fiber cells 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sod3):
     homeostasis/metabolism  immune system  mortality/aging  normal  skeleton 

    Find genes that share phenotypes with SOD3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sod3tm1Mrkl for SOD3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOD3

    miRNA
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    miRTarBase miRNAs that target SOD3:
    hsa-mir-21-5p (MIRT006997)

    Block miRNA regulation of human, mouse, rat SOD3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SOD3:
    hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidSOD3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SOD3
    Predesigned siRNA for gene silencing in human, mouse, rat SOD3

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SODE_HUMAN, P08294: Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate
    proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma
    and the endothelium
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol3
    mitochondrion3
    nucleus3
    peroxisome2
    lysosome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IBA--

    Find genes that share ontologies with SOD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOD3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Folate Metabolism
    Folate Metabolism0.54
    Vitamin B12 Metabolism0.54
    2Cellular Senescence
    Cellular responses to stress0.81
    3superoxide radicals degradation
    superoxide radicals degradation
    4Selenium Pathway
    Selenium Pathway
    5Selected targets of C EBPbeta
    Selected targets of C EBPbeta


    Find genes that share SuperPaths with SOD3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for SOD3
        Oxidative Stress
    Selenium Pathway
    Folate Metabolism
    Vitamin B12 Metabolism
    superoxide radicals degradation


    1 Reactome Pathway for SOD3
        Detoxification of Reactive Oxygen Species


        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOD3: 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Cellular Stress Responses in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SOD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SOD3 (P082943 ENSP000003715544) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBLN5Q9UBX53, ENSP000003450084I2D: score=1 STRING: ENSP00000345008
    CATENSP000002410524STRING: ENSP00000241052
    TYRP1ENSP000003735704STRING: ENSP00000373570
    HSCBENSP000002160274STRING: ENSP00000216027
    HSPA9ENSP000002971854STRING: ENSP00000297185
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006801superoxide metabolic process ----
    GO:0019430removal of superoxide radicals IBA--
    GO:0046688response to copper ion IEA--
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with SOD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOD3 (SODE)

    7 HMDB Compounds for SOD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    OxygenOxygen (see all 5)7782-44-7--
    Superoxidedioxidanidyl (see all 7)11062-77-4--
    ZincZinc (see all 2)7440-66-6--

    Selected Novoseek inferred chemical compound relationships for SOD3 gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    superoxide 89 656 16087389 (5), 16443677 (5), 8743981 (5), 17717013 (4) (see all 99)
    heparin 64.2 119 8864862 (5), 19754153 (5), 15362977 (4), 8452552 (4) (see all 42)
    heparan sulfate 62.3 25 16973718 (3), 12736188 (1), 9464851 (1), 15362977 (1) (see all 12)
    manganese superoxide 61.1 10 15362370 (1), 18094428 (1), 15755737 (1), 19477268 (1) (see all 7)
    oxygen 52.3 26 16471171 (2), 10811593 (1), 18203633 (1), 12406846 (1) (see all 18)
    peroxynitrite 50.3 5 9484979 (2), 7583586 (1), 16840738 (1)
    nitric oxide 47.9 93 10841522 (7), 11566193 (5), 10712391 (4), 16214176 (4) (see all 26)
    alpha-phenyl-n-tert-butylnitrone 46.4 1 16816350 (1)
    pyrogallol 44 4 2079230 (1), 12495809 (1), 8135741 (1)
    h2o2 40.9 10 18971527 (1), 12600029 (1), 17242675 (1), 15280800 (1)



    Find genes that share compounds with SOD3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOD3 gene: 
    NM_003102.2  

    Unigene Cluster for SOD3:

    Superoxide dismutase 3, extracellular
    Hs.2420  [show with all ESTs]
    Unigene Representative Sequence: BM906283
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000598411 ENST00000593742 ENST00000382120(uc003gqz.3)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK313935.1 BC014418.1 CR541853.1 J02947.1 

    4 DOTS entries:

    DT.212315  DT.100723316  DT.100795871  DT.100795866 

    Selected AceView cDNA sequences (see all 208):

    CR622278 CR592129 BF724293 CR597150 T28376 CR606896 CR608025 CR595031 
    AI669737 CR625060 BM723136 CR607978 CR618426 AA364831 BM709341 BX397186 
    AI888496 AW473468 BI830722 CD672545 BI762405 BI764958 AI635441 BX458879 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCGGCGGG
    SOD3 Expression
    About this image


    SOD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Brain (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus
     
     Thyroid (Endocrine System)
     
     Adipose (Muscoskeletal System)
    SOD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2420

    UniProtKB/Swiss-Prot: SODE_HUMAN, P08294
    Tissue specificity: Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in
    extracellular fluids such as plasma, lymph and synovial fluid

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOD3: 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Cellular Stress Responses in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SOD3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sod31 , 5 superoxide dismutase 3, extracellular1, 5 76.76(n)1
    70.67(a)1
      5 (27.92 cM)5
    206571  NM_011435.31  NP_035565.11 
     523638045 
    chicken
    (Gallus gallus)
    Aves SOD31 superoxide dismutase 3, extracellular 57.14(n)
    53.46(a)
      422810  XM_420760.4  XP_420760.4 
    lizard
    (Anolis carolinensis)
    Reptilia SOD36
    superoxide dismutase 3, extracellular
    45(a)
    1 ↔ 1
    5(73296826-73297548)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ085212.12   -- 67.28(n)    BJ085212.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sod3a1 superoxide dismutase 3, extracellular a 54.48(n)
    49.71(a)
      504078  NM_001099236.1  NP_001092706.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sod36
    Superoxide dismutase 3
    31(a)
    1 ↔ 1
    2R(7267849-7271613)
    worm
    (Caenorhabditis elegans)
    Secernentea sod-46
    Protein SOD-4, isoform b
    25(a)
    1 → many
    III(9497011-9500204) WBGene00004933
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SOD16
    Cytosolic copper-zinc superoxide dismutase; some m...
    36(a)
    1 → many
    X(622550-623014) YJR104C


    ENSEMBL Gene Tree for SOD3 (if available)
    TreeFam Gene Tree for SOD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOD3 gene
    SOD12  CCS2  
    1 SIMAP similar gene for SOD3 using alignment to 2 protein entries:     SODE_HUMAN (see all proteins):
    SOD1

    Find genes that share paralogs with SOD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    SODE_HUMAN, P08294: The variant Gly-231 which is found in about 2.2% of individual displays a 10-fold increased plasma
    EC-SOD content due to reduced heparin-binding affinity and thus the impairment of its binding ability to
    endothelial cell surface


    Selected SNPs for SOD3 (see all 210)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17998951,2,,4
    C,Fpathogenic124742159(+) AGAAGC/GGGCGG 2 R G mis1 ese37Minor allele frequency- G:0.05NS MN NA 570
    rs1872071601,2
    --24735431(+) CACATG/TCGTAT 1 -- us2k10--------
    rs1898910881,2
    --24735434(+) ATGCGA/TATACC 1 -- us2k10--------
    rs178796781,2
    C,F--24735481(+) CCTTCT/CGCATT 1 -- us2k13Minor allele frequency- C:0.01NS NA 184
    rs1872543631,2
    --24735552(+) TTTTTC/TCTCCA 1 -- us2k10--------
    rs415326491,2
    C,F--24735784(+) TGTTAC/TCAAAG 1 -- us2k12Minor allele frequency- T:0.03NA WA 164
    rs133067031,2
    C,F--24735836(+) GGTGGC/TGAGAA 1 -- us2k116Minor allele frequency- T:0.18NS NA WA CSA EA 1322
    rs1901619531,2
    --24735917(+) ACCAGA/CACGGA 1 -- us2k10--------
    rs178810811,2
    C,F--24735919(+) CAGAAC/TGGAGA 1 -- us2k11Minor allele frequency- T:0.01NS 166
    rs178859211,2
    C,F--24735926(+) GAGACG/ATGCTT 1 -- us2k13Minor allele frequency- A:0.03NS NA WA 332

    HapMap Linkage Disequilibrium report for SOD3 (24791534 - 24802467 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SOD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829887CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): SOD3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOD3
    DNA2.0 Custom Variant and Variant Library Synthesis for SOD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 185490    OMIM disorders: --

    16 diseases for SOD3:    
    About MalaCards
    keratopathy    coronary stenosis    bullous keratopathy    usual interstitial pneumonia
    myocardial stunning    diabetic polyneuropathy    asbestosis    adult respiratory distress syndrome
    hyperhomocysteinemia    keratoconus    diabetic neuropathy    cerebrovascular disease
    pulmonary fibrosis    coronary artery disease    myocardial infarction    amyotrophic lateral sclerosis

    2 diseases from the University of Copenhagen DISEASES database for SOD3:
    Vascular disease     Pulmonary fibrosis

    Find genes that share disorders with SOD3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SOD3 gene (see all 37)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pulmonary fibrosis 34.5 9 17999630 (3), 18165226 (1), 19073610 (1), 16224105 (1)
    bullous keratopathy 34.3 2 17679946 (2)
    atherosclerosis 32.4 16 16191429 (2), 15329502 (2), 9484979 (1), 18726685 (1) (see all 11)
    lung diseases 29.5 4 10194479 (1), 9184535 (1), 19465032 (1)
    keratoconus 28.3 5 17679946 (5)
    coronary artery disease 27.8 14 16191429 (1), 17644511 (1), 9848884 (1), 15329502 (1) (see all 6)
    pulmonary disease chronic obstructive 26.6 2 18703790 (1), 18948423 (1)
    cardiovascular diseases 26.4 3 11350569 (1), 15451065 (1)
    zinc deficiency 18.6 2 11437176 (1), 10383098 (1)
    cerebral vasospasm 17.3 4 12574556 (2), 15472087 (2)

    Genetic Association Database (GAD): SOD3
    Human Genome Epidemiology (HuGE) Navigator: SOD3 (53 documents)

    Export disorders for SOD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOD3 gene, integrated from 10 sources (see all 357):
    (articles sorted by number of sources associating them with SOD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An arginine-213 to glycine mutation in human extracellular-superoxide dismutase reduces susceptibility to trypsin-like proteinases. (PubMed id 8864862)1, 2, 9 Adachi T....Hirano K. (J. Biochem. 1996)
    2. Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. (PubMed id 18948423)1, 4, 9 Arcaroli J.J....Crapo J.D. (Am. J. Respir. Crit. Care Med. 2009)
    3. Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene. (PubMed id 7959763)1, 2, 9 Folz R.J. and Crapo J.D. (Genomics 1994)
    4. 10-fold increase in human plasma extracellular superoxide dismutase content caused by a mutation in heparin-binding domain. (PubMed id 8034674)1, 2, 9 Sandstrom J.... Marklund S.L. (J. Biol. Chem. 1994)
    5. The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro. (PubMed id 1505778)1, 2, 9 Adachi T.... Marklund S.L. (Free Radic. Biol. Med. 1992)
    6. The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding. (PubMed id 19289127)1, 2, 9 Antonyuk S.V.... Hasnain S.S. (J. Mol. Biol. 2009)
    7. Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (PubMed id 19108943)1, 4, 9 Rosta K....VAcr A. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2009)
    8. Multiplex single base extension method for simultaneous genotyping of non-synonymous SNP in the three human SOD genes. (PubMed id 19016244)1, 4, 9 Iida R....Yasuda T. (Electrophoresis 2008)
    9. Polymorphic variants of extracellular superoxide dismutase gene in a Romanian population with atheroma. (PubMed id 18726685)1, 4, 9 Samoila O.C....Seclaman E. (Biochem. Genet. 2008)
    10. Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study. (PubMed id 17646272)1, 4, 9 Kang D....Hayes R.B. (amp 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6649 HGNC: 11181 AceView: SOD3 Ensembl:ENSG00000109610 euGenes: HUgn6649
    ECgene: SOD3 H-InvDB: SOD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOD3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/sod3/
    Wikipedia http://en.wikipedia.org/wiki/Superoxide_dismutase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOD3 gene:
    Search GeneIP for patents involving SOD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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