Aliases for SOD3 Gene
External Ids for SOD3 Gene
Previous GeneCards Identifiers for SOD3 Gene
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
GeneCards Summary for SOD3 Gene
SOD3 (Superoxide Dismutase 3, Extracellular) is a Protein Coding gene. Diseases associated with SOD3 include Asbestosis and Diabetic Polyneuropathy. Among its related pathways are Oxidative Stress and Cellular Senescence. GO annotations related to this gene include heparin binding and superoxide dismutase activity. An important paralog of this gene is CCS.
UniProtKB/Swiss-Prot for SOD3 Gene
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.