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SOD2 Gene

protein-coding   GIFtS: 76
GCID: GC06M160102

Superoxide Dismutase 2, Mitochondrial

  See SOD2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Superoxide Dismutase 2, Mitochondrial1 2     Indophenoloxidase B2
EC 1.15.1.13 8     Manganese-Containing Superoxide Dismutase2
MNSOD2 5     Mangano-Superoxide Dismutase2
MVCD62 5     Mn Superoxide Dismutase2
IPOB2     Superoxide Dismutase [Mn], Mitochondrial2

External Ids:    HGNC: 111801   Entrez Gene: 66482   Ensembl: ENSG000001120967   OMIM: 1474605   UniProtKB: P041793   

Export aliases for SOD2 gene to outside databases

Previous GC identifers: GC06M159539 GC06M159973 GC06M160009 GC06M160012 GC06M160070 GC06M160020 GC06M157570


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOD2 Gene:
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that
forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of
oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have
been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer.
Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SOD2 Gene:
SOD2 (superoxide dismutase 2, mitochondrial) is a protein-coding gene. Diseases associated with SOD2 include microvascular complications of diabetes 6, and motor neuron disease. GO annotations related to this gene include oxygen binding and identical protein binding.

UniProtKB/Swiss-Prot: SODM_HUMAN, P04179
Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to
biological systems

Gene Wiki entry for SOD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOD2 gene promoter:
         ATF-2   AP-2alpha isoform 2   c-Jun   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): SOD2 promoter sequence
   Search Chromatin IP Primers for SOD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25

SOD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOD2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M160102:  view genomic region     (about GC identifiers)

Start:
160,090,089 bp from pter      End:
160,183,561 bp from pter
Size:
93,473 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SODM_HUMAN, P04179 (See protein sequence)
Recommended Name: Superoxide dismutase [Mn], mitochondrial precursor  
Size: 222 amino acids; 24722 Da
Cofactor: Binds 1 manganese ion per subunit
Subunit: Homotetramer
Selected PDB 3D structures from and Proteopedia for SOD2 (see all 27):
1AP5 (3D)        1AP6 (3D)        1EM1 (3D)        1JA8 (3D)        1LUV (3D)        1LUW (3D)    
Secondary accessions: B2R7R1 B3KUK2 B4DL20 B4E3K9 E1P5A9 P78434 Q16792 Q5TCM1 Q96EE6 Q9P2Z3
Alternative splicing: 4 isoforms:  P04179-1   P04179-2   P04179-3   P04179-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SOD2: NX_P04179

Explore proteomics data for SOD2 at MOPED

Post-translational modifications: 

  • Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity1
  • Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or
    after long fasting (By similarity)1
  • Ubiquitination2 at Lys130
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SOD2 (P04179) (see all 21)
     WEHAYYL  KHSLPDL  IKRDFGS  KGDVTAQ 


    See SOD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000627.2  NP_001019636.1  NP_001019637.1  

    ENSEMBL proteins: 
     ENSP00000446252   ENSP00000356022   ENSP00000440131   ENSP00000356021   ENSP00000442920  
     ENSP00000404804   ENSP00000337127   ENSP00000441362   ENSP00000445015   ENSP00000439191  
     ENSP00000384196   ENSP00000406713  
    Reactome Protein details: P04179

    SOD2 Human Recombinant Protein Products:

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    Novus Biologicals SOD2 Proteins
    Novus Biologicals SOD2 Lysates
    Sino Biological Recombinant Protein for SOD2
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SOD2
    Cloud-Clone Corp. Proteins for SOD2

     
    Search eBioscience for Proteins for SOD2 

    SOD2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SOD2
    R&D Systems Antibodies for SOD2 (SOD2/Mn-SOD)
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    SOD2 Assay Products:

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    Cloud-Clone Corp. ELISAs for SOD2
    Cloud-Clone Corp. CLIAs for SOD2
    Search eBioscience for ELISAs for SOD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR019831 Mn/Fe_SOD_N
     IPR001189 Mn/Fe_SOD
     IPR019832 Mn/Fe_SOD_C
     IPR019833 Mn/Fe_SOD_BS

    Graphical View of Domain Structure for InterPro Entry P04179

    ProtoNet protein and cluster: P04179

    1 Blocks protein domain: IPB001189 Manganese and iron superoxide dismutase

    UniProtKB/Swiss-Prot: SODM_HUMAN, P04179
    Similarity: Belongs to the iron/manganese superoxide dismutase family


    Find genes that share domains with SOD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SODM_HUMAN, P04179
    Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to
    biological systems
    Catalytic activity: 2 superoxide + 2 H(+) = O(2) + H(2)O(2)
    Induction: Expression is regulated by KRIT1

         Genatlas biochemistry entry for SOD2:
    manganese superoxide dismutase 2,mitochondrial,catabolic pathway of activated oxygen species,free radical
    detoxification,susceptibility factor for non familial idiopathy dilated cardiomyopathy in Japanese

         Enzyme Number (IUBMB): EC 1.15.1.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004784superoxide dismutase activity TAS--
    GO:0005515protein binding ----
    GO:0019825oxygen binding IEA--
    GO:0030145manganese ion binding TAS10511315
         
    Find genes that share ontologies with SOD2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SOD2:
     Synthetic lethal with paclitax 

         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sod2) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size/body 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  muscle  nervous system  other 

    Find genes that share phenotypes with SOD2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SOD2: Sod2tm1Cje Sod2tm1.1Kskk Sod2tm1Leb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SOD2:
    hsa-mir-342-3p (MIRT043729), hsa-mir-377-3p (MIRT000993), hsa-mir-30a-5p (MIRT028409), hsa-mir-222-3p (MIRT000135), hsa-mir-769-3p (MIRT039083), hsa-mir-17-3p (MIRT005745)

    Block miRNA regulation of human, mouse, rat SOD2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SOD2:
    hsa-miR-187* hsa-miR-1283 hsa-miR-330-3p hsa-miR-2278 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidSOD2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SOD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SOD2

    Clone
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    OriGene ORF clones in mouse, rat for SOD2
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    GenScript: all cDNA clones in your preferred vector (see all 3): SOD2 (NM_000636)
    Sino Biological Human cDNA Clone for SOD2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOD2
    Addgene plasmids for SOD2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SODM_HUMAN, P04179: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast3
    cytosol3
    extracellular3
    nucleus3
    plasma membrane3
    cytoskeleton2
    endoplasmic reticulum2
    lysosome2
    peroxisome2
    vacuole2
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA12551919
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005759mitochondrial matrix TAS10511315
    GO:0042645mitochondrial nucleoid IEA--

    Find genes that share ontologies with SOD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOD2 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular responses to stress0.81
    2PEDF Induced Signaling
    PEDF Induced Signaling0.73
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    4Wnt Signaling Pathway (WikiPathways)
    DNA damage response (only ATM dependent)0.32
    5superoxide radicals degradation
    superoxide radicals degradation


    Find genes that share SuperPaths with SOD2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOD2
        PEDF Induced Signaling

    1 GeneGo (Thomson Reuters) Pathway for SOD2
        Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

    5 BioSystems Pathways for SOD2
        DNA damage response (only ATM dependent)
    Oxidative Stress
    Selenium Pathway
    FoxO family signaling
    superoxide radicals degradation


    1 Reactome Pathway for SOD2
        Detoxification of Reactive Oxygen Species


    3 Kegg Pathways  (Kegg details for SOD2):
        FoxO signaling pathway
    Peroxisome
    Huntington's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOD2 (see all 11): 
              Nephrotoxicity in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SOD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SOD2 (P041791, 3 ENSP000003371274) via UniProtKB, MINT, STRING, and/or I2D (see all 268)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMY1AP047453, ENSP000003591004I2D: score=1 STRING: ENSP00000359100
    AMY1BP047453I2D: score=1 
    AMY1CP047453I2D: score=1 
    KIAA1549Q9HCM33, ENSP000002423654I2D: score=3 STRING: ENSP00000242365
    RAB4AP203383, ENSP000003556514I2D: score=3 STRING: ENSP00000355651
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 61):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species ----
    GO:0000303response to superoxide IMP16179351
    GO:0001306age-dependent response to oxidative stress ----
    GO:0001315age-dependent response to reactive oxygen species IMP14980699
    GO:0001666response to hypoxia IEA--

    Find genes that share ontologies with SOD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOD2 (SODM)

    7 HMDB Compounds for SOD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    OxygenOxygen (see all 5)7782-44-7--
    Superoxidedioxidanidyl (see all 7)11062-77-4--
    ZincZinc (see all 2)7440-66-6--

    2 DrugBank Compounds for SOD2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-Fluorotyrosine-- 403-90-7target--17139284 17016423 10592235
    Benzylsulfinic Acid-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for SOD2 gene (see all 144)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    manganese superoxide 99.1 2165 7856748 (7), 11207049 (7), 16365243 (6), 9081096 (5) (see all 99)
    superoxide 91.8 911 18247479 (4), 2230537 (4), 7969912 (4), 10529750 (3) (see all 99)
    zinc superoxide 84.7 77 7856748 (6), 9989524 (2), 10692109 (2), 15258423 (2) (see all 44)
    oxygen 79.1 274 11536448 (4), 1385428 (3), 7914182 (2), 11159050 (2) (see all 99)
    manganese 76.3 184 1550052 (6), 10521117 (6), 12950012 (4), 12215453 (3) (see all 90)
    h2o2 73.6 158 16114557 (5), 9535218 (3), 10919671 (3), 19306099 (3) (see all 84)
    copper 64.4 150 7856748 (6), 14531733 (4), 1793616 (3), 9989524 (2) (see all 85)
    peroxynitrite 63.9 44 11152462 (5), 9603906 (4), 9425011 (2), 19917352 (2) (see all 20)
    n acetylcysteine 60.1 27 11709424 (2), 18829485 (2), 9518260 (1), 18281048 (1) (see all 16)
    3-nitrotyrosine 56.4 10 16895800 (3), 14656937 (2), 9848095 (1), 16765071 (1) (see all 5)

    1 PharmGKB related drug/compound annotation for SOD2 gene    About this table
    Drug/compound PharmGKB Annotation
    cyclophosphamideCA  



    Find genes that share compounds with SOD2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOD2 gene (3 alternative transcripts): 
    NM_000636.2  NM_001024465.1  NM_001024466.1  

    Unigene Cluster for SOD2:

    Superoxide dismutase 2, mitochondrial
    Hs.487046  [show with all ESTs]
    Unigene Representative Sequence: BC041951
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538183(uc003qsg.3 uc003qsh.3 uc003qsi.1 uc011efu.1 uc011efv.1)
    ENST00000367055 ENST00000546260 ENST00000367054 ENST00000546087 ENST00000444946
    ENST00000337404 ENST00000535459 ENST00000541573 ENST00000540491 ENST00000545162
    ENST00000535561 ENST00000537657 ENST00000401980 ENST00000452684(uc003qsj.3)
    ENST00000535372(uc003qsp.3)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOD2
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      QuantiFast Probe-based Assays in human, mouse, rat SOD2

    Additional mRNA sequence: 

    AK296809.1 AK304766.1 AK313082.1 AL050388.1 AY280718.1 AY280719.1 AY280720.1 AY280721.1 
    BC012423.1 BC016015.1 BC016934.1 BC035422.1 BC041951.1 BT006967.1 DQ003134.1 M31163.1 
    M36693.1 X07834.1 X14322.1 X15132.1 X59445.1 Y00472.1 Y00985.1 

    Selected DOTS entries (see all 55):

    DT.101985421  DT.95350909  DT.420015  DT.97856570  DT.91763736  DT.95189349  DT.100828782  DT.100828766 
    DT.100828787  DT.121326891  DT.121326878  DT.121327136  DT.121327061  DT.121326777  DT.86851629  DT.100828778 
    DT.121327128  DT.87001758  DT.100692392  DT.100828790  DT.100828793  DT.100688162  DT.121327054  DT.99947916 

    Selected AceView cDNA sequences (see all 538):

    BF060664 CA396748 C05227 AI473383 AW875816 BE882897 BE795371 BE267937 
    AA375754 CA306165 BM272570 AA343663 CA446393 BQ009368 CA306232 BQ575691 
    AA361447 AI459858 AI424625 AI288966 BP343473 BQ950610 AW794755 AA921886 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SOD2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
    SP1:                                -     -     -                                   -     -     -         
    SP2:                                -     -     -                                                         
    SP3:                                -     -     -                                                         
    SP4:                                -     -     -     -                             -     -     -         
    SP5:                                      -     -                                                         


    ECgene alternative splicing isoforms for SOD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTTAAAGT
    SOD2 Expression
    About this image


    SOD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Epithelial Cells
             Fetal Corneal Basal Epithelial Cells Corneal Epithelium
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Fetal Corneal Basal Epithelial Cells Corneal Epithelium
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SOD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487046
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOD2 (see all 11): 
              Nephrotoxicity in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Diabetes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SOD2 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sod21 , 5 superoxide dismutase 2, mitochondrial1, 5 86.94(n)1
    90.09(a)1
      17 (8.75 cM)5
    206561  NM_013671.31  NP_038699.21 
     130078395 
    chicken
    (Gallus gallus)
    Aves SOD21 superoxide dismutase 2, mitochondrial 79.73(n)
    84.68(a)
      374042  NM_204211.1  NP_989542.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOD26
    superoxide dismutase 2, mitochondrial
    81(a)
    1 ↔ 1
    1(212242952-212259695)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238832 Xenopus laevis manganese superoxide dismutase mRNA, more 78.32(n)    AY362041.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sod22 superoxide dismutase 2, mitochondrial 77.91(n)   335799  BC060895.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sod21 , 3 superoxide metabolism manganese
    superoxide dismutase3
    Superoxide dismutase 2 (Mn)1
    62(a)3
    62.87(n)1
    62.38(a)1
      53C153
    368781  NM_057577.31  NP_476925.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sod-21 , 3 superoxide dismutase3
    sod-21
    64(a)
    (best of 2)3
    61.84(n)1
    63.8(a)1
      I(8442616-8443737)3
    1726321  NM_059889.41  NP_492290.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SOD2(YHR008C)4
    SOD21
    Mitochondrial manganese superoxide dismutase, protects more4
    SOD21
    55.07(n)1
    49.02(a)1
      8(123590-122889)4
    8563991, 4  NP_011872.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MSD11 MSD1 60.66(n)
    57.82(a)
      820263  NM_111929.3  NP_187703.1 
    rice
    (Oryza sativa)
    Liliopsida Os.46102 Oryza sativa manganese superoxide dismutase (rmsod1) more 78.13(n)    AK070528.1 


    ENSEMBL Gene Tree for SOD2 (if available)
    TreeFam Gene Tree for SOD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOD2 gene
    1 SIMAP similar gene for SOD2 using alignment to 14 protein entries:     SODM_HUMAN (see all proteins):
    DKFZp564M2422

    Find genes that share paralogs with SOD2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SOD2
    PGOHUM00000244124


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOD2 (see all 433)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48801,2,,4
    C,F,Hother1160113872(-) TCCGGT/CTTTGG 6 /A /V mis139Minor allele frequency- C:0.42MN NS EA NA WA CSA EU 8592
    rs1820432671,2
    --160099662(+) CATAAA/GTAGAG 2 -- ds50010--------
    rs1878911691,2
    --160099729(+) TCACGA/GGAACC 2 -- ds50010--------
    rs773989301,2
    C,F--160099857(+) CAGAAT/ATGAAT 2 -- ds50012Minor allele frequency- A:0.07CSA WA 120
    rs1125270251,2
    C,F--160099976(+) CTTTTA/CGGTTA 2 -- ds50012Minor allele frequency- C:0.04NA 122
    rs28429801,2
    C,F,A,H--160100116(-) AAAACA/TTTAAA 2 -- ds500134Minor allele frequency- T:0.31NA NS EA WA CSA 3175
    rs78551,2
    C,F,H--160100302(+) AGGACA/GTTATC 2 -- ut3115Minor allele frequency- G:0.03MN NS EA NA 1796
    rs1926729711,2
    --160100625(+) ACAGAC/TAGAAT 2 -- int10--------
    rs80311,2
    C,F,O,A,H--160100640(-) AATACT/AGTTTT 2 -- int134Minor allele frequency- A:0.26MN EA NA NS WA CSA 4759
    rs735993281,2
    C--160100734(+) TCAGTC/TACAAA 2 -- int12Minor allele frequency- T:0.04WA 120

    HapMap Linkage Disequilibrium report for SOD2 (160090089 - 160183561 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SOD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv886806CNV Loss21882294
    esv33081CNV Gain17666407
    dgv2023e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SOD2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOD2
    DNA2.0 Custom Variant and Variant Library Synthesis for SOD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147460   
    OMIM disorders: 612634  
    UniProtKB/Swiss-Prot: SODM_HUMAN, P04179
  • Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in
    numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic
    nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major
    cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased
    tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • 18 diseases for SOD2:    
    About MalaCards
    microvascular complications of diabetes 6    motor neuron disease    nephronophthisis 16    spinocerebellar ataxia type 3
    tetraploidy    diabetic angiopathy    myelomeningocele    aceruloplasminemia
    extrinsic allergic alveolitis    progeria    aseptic meningitis    barrett's esophagus
    diabetic macular edema    meningitis    malignant mesothelioma    in situ carcinoma
    multiple chemical sensitivity    amyotrophic lateral sclerosis

    18 diseases from the University of Copenhagen DISEASES database for SOD2:
    Amyotrophic lateral sclerosis     Vascular disease     Diabetes mellitus     Toxic encephalopathy
    Brain disease     Heart disease     Cancer     Lung disease
    Hyperglycemia     Down syndrome     Alzheimer's disease     Kidney failure
    Liver disease     Eye disease     Pancreatitis     Arthritis
    Proteinuria     Neuropathy

    Find genes that share disorders with SOD2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SOD2 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 58.7 129 20514411 (4), 1960995 (3), 2406241 (2), 2222450 (2) (see all 75)
    tumors 54.5 432 12469139 (8), 10919671 (6), 1988135 (6), 7780953 (4) (see all 99)
    amyotrophic lateral sclerosis 49 18 7985495 (2), 9452823 (2), 7699393 (1), 7719145 (1) (see all 12)
    cancer 47.5 158 19074833 (5), 19405048 (4), 19467856 (4), 9926924 (3) (see all 87)
    cell damage 42.9 10 11729237 (3), 7524486 (1), 20107204 (1), 8360707 (1) (see all 7)
    neurodegenerative diseases 42 4 10762167 (1), 8334770 (1), 12618592 (1)
    neurodegeneration 40.1 3 17251466 (1), 16485861 (1), 14681883 (1)
    shock 35.5 46 15128298 (2), 1337859 (2), 7514009 (2), 8144583 (1) (see all 31)
    breast cancer 35.1 148 15386537 (5), 15184255 (5), 16945136 (4), 17965603 (4) (see all 49)
    merrf 34.2 3 11403514 (1), 11907800 (1)

    Genetic Association Database (GAD): SOD2
    Human Genome Epidemiology (HuGE) Navigator: SOD2 (302 documents)

    Export disorders for SOD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOD2 gene, integrated from 10 sources (see all 1667):
    (articles sorted by number of sources associating them with SOD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients. (PubMed id 12624725)1, 2, 4, 9 Nomiyama T.... Kawamori R. (J. Hum. Genet. 2003)
    2. Complementary DNA encoding human colon cancer manganese superoxide dismutase and the expression of its gene in human cells. (PubMed id 1988135)1, 2, 9 St Clair D.K. and Holland J.C. (Cancer Res. 1991)
    3. Plasma selenium, manganese superoxide dismutase, and intermediate- or high-risk prostate cancer. (PubMed id 19528373)1, 4, 9 Chan J.M....Kantoff P.W. (J. Clin. Oncol. 2009)
    4. Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women. (PubMed id 15883815)1, 4, 9 Bergman M....Wingren S. (J. Cancer Res. Clin. Oncol. 2005)
    5. Association between manganese superoxide dismutase gene polymorphism and risk of prostate cancer: a meta-analysis. (PubMed id 19647296)1, 4, 9 Liwei L....Ruifa H. (Urology 2009)
    6. Manganese superoxide dismutase gene polymorphism, MnSOD plasma levels and risk of epithelial ovarian cancer. (PubMed id 18834346)1, 4, 9 Dalan A.B....Isbir T. (J. Obstet. Gynaecol. Res. 2008)
    7. Manganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland). (PubMed id 12948282)1, 4, 9 Woodson K....Albanes D. (amp 2003)
    8. Manganese superoxide dismutase (MnSOD) gene (Ala-9Val, Ile58Thr) polymorphism in patients with age-related macular degeneration (AMD). (PubMed id 20357718)1, 4, 9 Kowalski M....Szemraj J. (Med. Sci. Monit. 2010)
    9. Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism may not be associated with schizophrenia and tardive dyskinesia. (PubMed id 17582511)1, 4, 9 Pae C.U....Paik I.H. (Psychiatry Res 2007)
    10. [Functional polymorphism of manganese superoxide dismutase (MnSOD) gene correlates with schizophrenia in Polish population]. (PubMed id 16780268)1, 4, 9 GaA8ecki P....Zboralski K. (Pol. Merkur. Lekarski 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6648 HGNC: 11180 AceView: SOD2 Ensembl:ENSG00000112096 euGenes: HUgn6648
    ECgene: SOD2 Kegg: 6648 H-InvDB: SOD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOD2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/sod2/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=SOD2
    Wikipedia http://en.wikipedia.org/wiki/Superoxide_dismutase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOD2 gene:
    Search GeneIP for patents involving SOD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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