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Aliases for SOD2 Gene

Aliases for SOD2 Gene

  • Superoxide Dismutase 2, Mitochondrial 2 3
  • EC 1.15.1.1 4 63
  • Manganese-Containing Superoxide Dismutase 3
  • Mangano-Superoxide Dismutase 3
  • Mn Superoxide Dismutase 3
  • Indophenoloxidase B 3
  • MNSOD 3
  • MVCD6 3
  • IPOB 3

External Ids for SOD2 Gene

Previous GeneCards Identifiers for SOD2 Gene

  • GC06M159539
  • GC06M159973
  • GC06M160009
  • GC06M160012
  • GC06M160070
  • GC06M160020
  • GC06M160102
  • GC06M157570

Summaries for SOD2 Gene

Entrez Gene Summary for SOD2 Gene

  • This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOD2 Gene

SOD2 (Superoxide Dismutase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with SOD2 include microvascular complications of diabetes 6 and aseptic meningitis. Among its related pathways are Glucose / Energy Metabolism and Cellular Senescence. GO annotations related to this gene include identical protein binding and oxygen binding.

UniProtKB/Swiss-Prot for SOD2 Gene

  • Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Gene Wiki entry for SOD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOD2 Gene

Genomics for SOD2 Gene

Regulatory Elements for SOD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SOD2 Gene

Chromosome:
6
Start:
159,669,057 bp from pter
End:
159,762,529 bp from pter
Size:
93,473 bases
Orientation:
Minus strand

Genomic View for SOD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOD2 Gene

Proteins for SOD2 Gene

  • Protein details for SOD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04179-SODM_HUMAN
    Recommended name:
    Superoxide dismutase [Mn], mitochondrial
    Protein Accession:
    P04179
    Secondary Accessions:
    • B2R7R1
    • B3KUK2
    • B4DL20
    • B4E3K9
    • E1P5A9
    • P78434
    • Q16792
    • Q5TCM1
    • Q96EE6
    • Q9P2Z3

    Protein attributes for SOD2 Gene

    Size:
    222 amino acids
    Molecular mass:
    24722 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 1 Mn(2+) ion per subunit.;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for SOD2 Gene

    Alternative splice isoforms for SOD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOD2 Gene

Proteomics data for SOD2 Gene at MOPED

Post-translational modifications for SOD2 Gene

  • Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
  • Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
  • Ubiquitination at Lys 130
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SOD2 (SOD2)

Domains & Families for SOD2 Gene

Protein Domains for SOD2 Gene

Graphical View of Domain Structure for InterPro Entry

P04179

UniProtKB/Swiss-Prot:

SODM_HUMAN :
  • Belongs to the iron/manganese superoxide dismutase family.
Family:
  • Belongs to the iron/manganese superoxide dismutase family.
genes like me logo Genes that share domains with SOD2: view

No data available for Gene Families for SOD2 Gene

Function for SOD2 Gene

Molecular function for SOD2 Gene

GENATLAS Biochemistry:
manganese superoxide dismutase 2,mitochondrial,catabolic pathway of activated oxygen species,free radical detoxification,susceptibility factor for non familial idiopathy dilated cardiomyopathy in Japanese
UniProtKB/Swiss-Prot CatalyticActivity:
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
UniProtKB/Swiss-Prot Function:
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
UniProtKB/Swiss-Prot Induction:
Expression is regulated by KRIT1.

Enzyme Numbers (IUBMB) for SOD2 Gene

Gene Ontology (GO) - Molecular Function for SOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0004784 superoxide dismutase activity TAS --
GO:0005515 protein binding --
GO:0016491 oxidoreductase activity --
GO:0019825 oxygen binding --
genes like me logo Genes that share ontologies with SOD2: view
genes like me logo Genes that share phenotypes with SOD2: view

Animal Models for SOD2 Gene

MGI Knock Outs for SOD2:

Animal Model Products

miRNA for SOD2 Gene

miRTarBase miRNAs that target SOD2

No data available for Transcription Factor Targets and HOMER Transcription for SOD2 Gene

Localization for SOD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOD2 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOD2 Gene COMPARTMENTS Subcellular localization image for SOD2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IDA 12551919
GO:0005743 mitochondrial inner membrane --
GO:0005759 mitochondrial matrix TAS 10511315
GO:0042645 mitochondrial nucleoid --
genes like me logo Genes that share ontologies with SOD2: view

Pathways & Interactions for SOD2 Gene

genes like me logo Genes that share pathways with SOD2: view

Pathways by source for SOD2 Gene

1 Qiagen pathway for SOD2 Gene
1 Cell Signaling Technology pathway for SOD2 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for SOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0000303 response to superoxide IMP 16179351
GO:0001306 age-dependent response to oxidative stress --
GO:0001315 age-dependent response to reactive oxygen species IMP 14980699
GO:0001666 response to hypoxia --
genes like me logo Genes that share ontologies with SOD2: view

No data available for SIGNOR curated interactions for SOD2 Gene

Drugs & Compounds for SOD2 Gene

(75) Drugs for SOD2 Gene - From: NovoSeek, HMDB, DrugBank, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paclitaxel Approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2505
Zinc Approved Pharma 1404
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2525
Valproic Acid Approved, Investigational Pharma HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 302
Allopurinol Approved Pharma 125

(75) Additional Compounds for SOD2 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
superoxide
  • Dioxidanidyl
  • Dioxide(1-)
  • Hyperoxid
  • Superoxide
  • Superoxide anion
11062-77-4
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine
genes like me logo Genes that share compounds with SOD2: view

Transcripts for SOD2 Gene

Unigene Clusters for SOD2 Gene

Superoxide dismutase 2, mitochondrial:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOD2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
SP1: - - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - -
SP5: - -
SP6: -
SP7: - -
SP8:

Relevant External Links for SOD2 Gene

GeneLoc Exon Structure for
SOD2
ECgene alternative splicing isoforms for
SOD2

Expression for SOD2 Gene

mRNA expression in normal human tissues for SOD2 Gene

mRNA differential expression in normal tissues according to GTEx for SOD2 Gene

This gene is overexpressed in Muscle - Skeletal (x16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOD2 Gene



SOURCE GeneReport for Unigene cluster for SOD2 Gene Hs.487046

genes like me logo Genes that share expression patterns with SOD2: view

Protein tissue co-expression partners for SOD2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SOD2 Gene

Orthologs for SOD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SOD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SOD2 35
  • 88.29 (n)
  • 91.44 (a)
SOD2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOD2 35
  • 88.59 (n)
  • 91.44 (a)
SOD2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sod2 35
  • 86.94 (n)
  • 90.09 (a)
Sod2 16
Sod2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SOD2 35
  • 99.83 (n)
  • 100 (a)
SOD2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sod2 35
  • 86.04 (n)
  • 87.84 (a)
oppossum
(Monodelphis domestica)
Mammalia SOD2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOD2 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOD2 35
  • 79.73 (n)
  • 84.68 (a)
SOD2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOD2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sod2 35
  • 72.82 (n)
  • 82.43 (a)
Str.15249 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23883 35
zebrafish
(Danio rerio)
Actinopterygii sod2 35
  • 72.58 (n)
  • 83.18 (a)
sod2 36
  • 79 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13830 35
fruit fly
(Drosophila melanogaster)
Insecta Sod2 37
  • 62 (a)
Sod2 35
  • 62.87 (n)
  • 62.38 (a)
Sod2 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MNSOD1 35
  • 63.62 (n)
  • 63.46 (a)
worm
(Caenorhabditis elegans)
Secernentea sod-2 37
  • 64 (a)
sod-3 37
  • 61 (a)
sod-2 35
  • 61.84 (n)
  • 63.8 (a)
sod-2 36
  • 64 (a)
OneToMany
sod-3 36
  • 61 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR160W 35
  • 55.61 (n)
  • 51.02 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03609g 35
  • 55.4 (n)
  • 50.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOD2 35
  • 55.07 (n)
  • 49.02 (a)
SOD2 36
  • 42 (a)
OneToOne
SOD2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MSD1 35
  • 60.66 (n)
  • 57.82 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7748 35
rice
(Oryza sativa)
Liliopsida Os.4610 35
Os05g0323900 35
  • 62.48 (n)
  • 59.16 (a)
corn
(Zea mays)
Liliopsida Zm.1987 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2423 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09560 35
  • 57.01 (n)
  • 51.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1486.01 35
  • 56.54 (n)
  • 52.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2788 36
  • 71 (a)
OneToOne
Species with no ortholog for SOD2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOD2 Gene

ENSEMBL:
Gene Tree for SOD2 (if available)
TreeFam:
Gene Tree for SOD2 (if available)

Paralogs for SOD2 Gene

Pseudogenes.org Pseudogenes for SOD2 Gene

genes like me logo Genes that share paralogs with SOD2: view

No data available for Paralogs for SOD2 Gene

Variants for SOD2 Gene

Sequence variations from dbSNP and Humsavar for SOD2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs4880 other, other, other, - 159,692,840(-) TCCGG(C/T)TTTGG missense, reference
rs7855 -- 159,679,270(+) AGGAC(A/G)TTATC utr-variant-3-prime
rs8031 -- 159,679,608(-) AATAC(A/T)GTTTT intron-variant
rs10370 -- 159,680,500(-) AAAAA(A/C)ATTTA intron-variant
rs11854 -- 159,680,304(+) AAGCA(A/G)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SOD2 Gene

Variant ID Type Subtype PubMed ID
dgv2023e1 CNV Complex 17122850
nsv886806 CNV Loss 21882294
esv33081 CNV Gain 17666407

Variation tolerance for SOD2 Gene

Residual Variation Intolerance Score: 43.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.35; 85.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOD2 Gene

HapMap Linkage Disequilibrium report
SOD2
Human Gene Mutation Database (HGMD)
SOD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOD2 Gene

Disorders for SOD2 Gene

MalaCards: The human disease database

(30) MalaCards diseases for SOD2 Gene - From: OMIM, ClinVar, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
microvascular complications of diabetes 6
  • diabetic nephropathy
aseptic meningitis
  • acute aseptic meningitis
aceruloplasminemia
  • ceruloplasmin deficiency
diabetic polyneuropathy
  • polyneuropathy in diabetes
ischemia
- elite association
Search SOD2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SODM_HUMAN
  • Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for SOD2

Genetic Association Database (GAD)
SOD2
Human Genome Epidemiology (HuGE) Navigator
SOD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOD2
genes like me logo Genes that share disorders with SOD2: view

No data available for Genatlas for SOD2 Gene

Publications for SOD2 Gene

  1. Resveratrol promotes osteogenic differentiation and protects against dexamethasone damage in murine induced pluripotent stem cells. (PMID: 19656070) Kao C.L. … Li H.Y. (Stem Cells Dev. 2010) 23 67
  2. Metal uptake by manganese superoxide dismutase. (PMID: 19699328) Whittaker J.W. (Biochim. Biophys. Acta 2010) 23 67
  3. Manganese superoxide dismutase: effect of the ala16val polymorphism on protein, activity, and mRNA levels in human breast cancer cell lines and stably transfected mouse embryonic fibroblasts. (PMID: 19756960) McAtee B.L. … Yager J.D. (Mol. Cell. Biochem. 2010) 23 67
  4. Cell-autonomous generation of mitochondrial superoxide is a signal for cell death in differentiated neuronal precursor cells. (PMID: 19819231) Scott C.J. … Levin L.A. (Brain Res. 2010) 23 67
  5. The biliprotein C-phycocyanin modulates the early radiation response: a pilot study. (PMID: 19914399) Ivanova K.G. … Boteva R.N. (Mutat. Res. 2010) 23 67

Products for SOD2 Gene

Sources for SOD2 Gene

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