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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SOD2 Gene

protein-coding GIFtS: 74
GCID: GC06M160102

superoxide dismutase 2, mitochondrial

Explore 247 diseases affiliated with
SOD2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Superoxide Dismutase 2, Mitochondrial¹ ²		Indophenoloxidase B²
EC 1.15.1.1³ ⁸		Manganese-Containing Superoxide Dismutase²
MNSOD² ⁵		Mangano-Superoxide Dismutase²
MVCD6² ⁵		Mn Superoxide Dismutase²
IPOB²		Superoxide Dismutase [Mn], Mitochondrial²

External Ids:	HGNC: 11180¹	Entrez Gene: 6648²	Ensembl: ENSG00000112096⁷	OMIM: 147460⁵	UniProtKB: P04179³

Export aliases for SOD2 gene to outside databases

Previous GC identifers: GC06M159539 GC06M159973 GC06M160009 GC06M160012 GC06M160070 GC06M160020 GC06M157570

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOD2:

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms

a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative

phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been

associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate

transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SODM_HUMAN, P04179

Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to

biological systems

Gene Wiki entry for SOD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SOD2 gene promoter:
ATF-2 AP-2alpha isoform 2 c-Jun AP-2alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): SOD2 promoter sequence

Search SABiosciences Chromatin IP Primers for SOD2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3 Ensembl cytogenetic band: 6q25.3 HGNC cytogenetic band: 6q25

SOD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOD2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M160102: view genomic region (about GC identifiers)

Start:	160,100,096 bp from pter	End:	160,183,561 bp from pter
Size:	83,466 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SODM_HUMAN, P04179 (See protein sequence)

Recommended Name: Superoxide dismutase [Mn], mitochondrial precursor

Size: 222 amino acids; 24722 Da

Cofactor: Binds 1 manganese ion per subunit

Subunit: Homotetramer

Subcellular location: Mitochondrion matrix

6/27 PDB 3D structures from and Proteopedia for SOD2 (see all 27):

1AP5 (3D)

1AP6 (3D)

1EM1 (3D)

1JA8 (3D)

1LUV (3D)

1LUW (3D)

Secondary accessions: B2R7R1 B4DL20 E1P5A9 P78434 Q16792 Q5TCM1 Q96EE6 Q9P2Z3

Alternative splicing: 2 isoforms: P04179-1 P04179-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SOD2: NX_P04179

Post-translational modifications:

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04179

4/21 DME Specific Peptides for SOD2 (P04179) (see all 21)

WEHAYYL

KHSLPDL

IKRDFGS

KGDVTAQ

SOD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000627.2 NP_001019636.1 NP_001019637.1

ENSEMBL proteins:

ENSP00000356022 ENSP00000440131 ENSP00000446252 ENSP00000356021 ENSP00000442920

ENSP00000404804 ENSP00000337127 ENSP00000441362 ENSP00000445015 ENSP00000439191

ENSP00000384196 ENSP00000406713

Human Recombinant Protein Products:

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	Novus Biologicals SOD2 Proteins Novus Biologicals SOD2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SOD2
	Uscn Proteins for SOD2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	IDA	12551919
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0005759	mitochondrial matrix	TAS	10511315

SOD2 for ontologies About GeneDecksing

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	Abcam antibodies for SOD2
	Uscn Antibodies for SOD2
	ThermoFisher Antibodies for SOD2

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SOD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SOD2 for domains About GeneDecksing

4 InterPro domains/families:

IPR019831 Mn/Fe_SOD_N

IPR001189 Mn/Fe_SOD

IPR019832 Mn/Fe_SOD_C

IPR019833 Mn/Fe_SOD_BS

Graphical View of Domain Structure for InterPro Entry P04179

ProtoNet protein and cluster: P04179

1 Blocks protein family: IPB001189 Manganese and iron superoxide dismutase

UniProtKB/Swiss-Prot: SODM_HUMAN, P04179

Similarity: Belongs to the iron/manganese superoxide dismutase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SODM_HUMAN, P04179

Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to

biological systems

Catalytic activity: 2 superoxide + 2 H(+) = O(2) + H(2)O(2)

Induction: Expression is regulated by KRIT1

Genatlas biochemistry entry for SOD2:

manganese superoxide dismutase 2,mitochondrial,catabolic pathway of activated oxygen species,free radical

detoxification,susceptibility factor for non familial idiopathy dilated cardiomyopathy in Japanese

Enzyme Number (IUBMB): EC 1.15.1.1¹ ²

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOD2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate SOD2:
		hsa-miR-187* hsa-miR-1283 hsa-miR-330-3p hsa-miR-2278 hsa-miR-646
		SwitchGear 3'UTR luciferase reporter plasmid: SOD2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOD2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0004784	superoxide dismutase activity	IMP	12551919
GO:0019825	oxygen binding	IEA	--
GO:0030145	manganese ion binding	TAS	10511315
GO:0042802	identical protein binding	IEA	--

SOD2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SOD2:

Synthetic lethal with paclitax

Animal Models:
Mouse knock-outs for SOD2: Sod2^tm1Cje Sod2^tm1.1Kskk Sod2^tm1Leb
15/20 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Sod2) (see all 20):

adipose tissue	behavior/neurological	cardiovascular system	cellular	growth/size
hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument
liver/biliary system	mortality/aging	muscle	nervous system	other

SOD2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development HGF signaling pathway

Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2

0.15

Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

0.15

PEDF Induced Signaling

PEDF Induced Signaling

1.00

Oxidative Stress

Oxidative Stress

1.00

Selenium Pathway

Selenium Pathway

1.00

FoxO family signaling

FoxO family signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SOD2

Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SOD2

PEDF Induced Signaling

1 GeneGo (Thomson Reuters) Pathway for SOD2

Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

5 BioSystems Pathways for SOD2

	DNA damage response (only ATM dependent)
	Selenium Pathway
	FoxO family signaling
	Oxidative Stress
	superoxide radicals degradation

2 Kegg Pathways (Kegg details for SOD2):

	Peroxisome
	Huntington's disease

SOD2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SOD2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/135 Interacting proteins for SOD2 (P04179³ ENSP00000337127⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 135)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AMY1A	P04745³, ENSP00000359100⁴	I2D: score=1 STRING: ENSP00000359100
AMY1B	P04745³	I2D: score=1
AMY1C	P04745³	I2D: score=1
AURKA	O14965³, ENSP00000216911⁴	I2D: score=2 STRING: ENSP00000216911
FH	P07954³, ENSP00000355518⁴	I2D: score=2 STRING: ENSP00000355518

About this table

Gene Ontology (GO): 5/58 biological process terms (GO ID links to tree view) (see all 58): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000302	response to reactive oxygen species	--	--
GO:0000303	response to superoxide	IMP	16179351
GO:0001306	age-dependent response to oxidative stress	--	--
GO:0001315	age-dependent response to reactive oxygen species	IMP	14980699
GO:0001666	response to hypoxia	IEA	--

SOD2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SOD2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SOD2

7 HMDB Compounds for SOD2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Copper	Cu (see all 2)	7440-50-8	--
Hydrogen peroxide	Hydrogen peroxide (see all 44)	7722-84-1	--
Iron	Armco iron (see all 19)	7439-89-6	--
Manganese	manganese	7439-96-5	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Superoxide	dioxidanidyl (see all 7)	11062-77-4	--
Zinc	Zinc (see all 2)	7440-66-6	--

2 DrugBank Compounds for SOD2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
3-Fluorotyrosine	--	403-90-7	target	--	17139284 17016423 10592235
Benzylsulfinic Acid	--	--	target	--	17139284 17016423 10592235

10/144 Novoseek chemical compound relationships for SOD2 gene (see all 144) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
manganese superoxide	99.1	2165	7856748 (7), 11207049 (7), 16365243 (6), 9081096 (5) (see all 99)
superoxide	91.8	911	18247479 (4), 2230537 (4), 7969912 (4), 10529750 (3) (see all 99)
zinc superoxide	84.7	77	7856748 (6), 9989524 (2), 10692109 (2), 15258423 (2) (see all 44)
oxygen	79.1	274	11536448 (4), 1385428 (3), 7914182 (2), 11159050 (2) (see all 99)
manganese	76.3	184	1550052 (6), 10521117 (6), 12950012 (4), 12215453 (3) (see all 90)
h2o2	73.6	158	16114557 (5), 9535218 (3), 10919671 (3), 19306099 (3) (see all 84)
copper	64.4	150	7856748 (6), 14531733 (4), 1793616 (3), 9989524 (2) (see all 85)
peroxynitrite	63.9	44	11152462 (5), 9603906 (4), 9425011 (2), 19917352 (2) (see all 20)
n acetylcysteine	60.1	27	11709424 (2), 18829485 (2), 9518260 (1), 18281048 (1) (see all 16)
3-nitrotyrosine	56.4	10	16895800 (3), 14656937 (2), 9848095 (1), 16765071 (1) (see all 5)

1 PharmGKB related drug/compound annotation for SOD2 gene

Drug/compound	PharmGKB Annotation
cyclophosphamide	CA

About this table

Search CenterWatch for drugs/clinical trials and news about SOD2 / SODM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SOD2 gene (3 alternative transcripts):

NM_000636.2 NM_001024465.1 NM_001024466.1

Unigene Cluster for SOD2:

Superoxide dismutase 2, mitochondrial

Hs.487046 [show with all ESTs]

Unigene Representative Sequence: BC041951

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367055 ENST00000546260 ENST00000538183(uc003qsg.3 uc003qsh.3 uc003qsi.1 uc011efu.1 uc011efv.1)

ENST00000367054 ENST00000546087 ENST00000444946 ENST00000337404 ENST00000535459

ENST00000541573 ENST00000540491 ENST00000545162 ENST00000535561 ENST00000537657

ENST00000401980 ENST00000452684(uc003qsj.3) ENST00000535372(uc003qsp.3)

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Additional cDNA sequence:

AK296809.1 AK304766.1 AK313082.1 AL050388.1 AY280718.1 AY280719.1 AY280720.1 AY280721.1

BC012423.1 BC016015.1 BC016934.1 BC035422.1 BC041951.1 BT006967.1 DQ003134.1 M31163.1

M36693.1 X07834.1 X14322.1 X15132.1 X59445.1 Y00472.1 Y00985.1

24/48 DOTS entries (see all 48):

DT.101985421 DT.95350909 DT.97856570 DT.100828782 DT.91763736 DT.420015 DT.121326878 DT.95189349

DT.121327136 DT.100828766 DT.86851629 DT.121327128 DT.87001758 DT.100692392 DT.100828787 DT.100828790

DT.100688162 DT.100828778 DT.121326777 DT.121327054 DT.121327061 DT.121326809 DT.121326891 DT.99947916

24/538 AceView cDNA sequences (see all 538):

N78706 BU621731 CA306232 AW875816 AA363542 AA622960 AA234454 BM976348

AU280001 BE795371 BE397333 BM768463 BQ691900 AI090959 AA361447 CA306165

AI601227 CB111188 AI424625 BQ009368 AA344744 AI339693 BM470662 BM272570

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SOD2 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f	^	9
SP1:											-		-		-												-		-		-
SP2:											-		-		-
SP3:											-		-		-
SP4:											-		-		-		-										-		-		-
SP5:													-		-

ECgene alternative splicing isoforms for SOD2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SOD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCTTAAAGT

About this image

SOD2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SOD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SOD2

SOURCE GeneReport for Unigene cluster: Hs.487046

SABiosciences Expression via Pathway-Focused PCR Arrays including SOD2 (see all 11):

Nephrotoxicity in human mouse rat

NFKB Signaling Targets in human mouse rat

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Diabetes in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SOD2 gene from 11/43 species (see all 43) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sod2^{1 , 5}	superoxide dismutase 2, mitochondrial^{1, 5}	86.94(n)¹ 90.09(a)¹		17 (8.75 cM)⁵ 20656¹ NM_013671.3¹ NP_038699.2¹ 13007839⁵
chicken (Gallus gallus)	Aves	SOD2¹	superoxide dismutase 2, mitochondrial	79.73(n) 84.68(a)		374042 NM_204211.1 NP_989542.1
lizard (Anolis carolinensis)	Reptilia	SOD2⁶	--	80(a)	1 ↔ 1	1(212248300-212258218)
African clawed frog (Xenopus laevis)	Amphibia	Xl.23883²	Xenopus laevis manganese superoxide dismutase mRNA, more	78.32(n)		AY362041.1
zebrafish (Danio rerio)	Actinopterygii	sod2²	superoxide dismutase 2, mitochondrial	77.91(n)		335799 BC060895.1
fruit fly (Drosophila melanogaster)	Insecta	Sod2^{1 , 3}	superoxide metabolism manganese superoxide dismutase³ Superoxide dismutase 2 (Mn)¹	62(a)³ 62.87(n)¹ 62.38(a)¹		53C15³ 36878¹ NM_057577.3¹ NP_476925.1¹
worm (Caenorhabditis elegans)	Secernentea	sod-2^{1 , 3}	superoxide dismutase³ Protein SOD-2¹	64(a) (best of 2)³ 62.96(n)¹ 65.28(a)¹		I(8442616-8443737)³ 172632¹ NM_059889.3¹ NP_492290.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SOD2(YHR008C)⁴ SOD2¹	Mitochondrial manganese superoxide dismutase, protects more⁴ Sod2p¹	54.9(n)¹ 49.02(a)¹		8(123590-122889)⁴ 856399^{1, 4} NP_011872.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	MSD1¹	Superoxide dismutase [Mn]	60.98(n) 58.54(a)		820263 NM_111929.3 NP_187703.1
rice (Oryza sativa)	Liliopsida	Os.4610²	Oryza sativa manganese superoxide dismutase (rmsod1) more	78.13(n)		AK070528.1

ENSEMBL Gene Tree for SOD2 (if available)
TreeFam Gene Tree for SOD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SOD2 gene

1 SIMAP similar gene for SOD2 using alignment to 16 protein entries: SODM_HUMAN (see all proteins):

DKFZp564M2422

SOD2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SOD2
PGOHUM00000244124

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4880^1,2	C,F,H,	other	160113872(-)	`TCCGGT/CTTTGG`	6	/A /V	mis¹		39		MN NS EA NA WA CSA EU	8592
rs182043267^1,2		--	160099662(+)	`CATAAA/GTAGAG`	2	--	ds500¹		0	--	--	--	--
rs187891169^1,2		--	160099729(+)	`TCACGA/GGAACC`	2	--	ds500¹		0	--	--	--	--
rs77398930^1,2		--	160099857(+)	`CAGAAT/ATGAAT`	2	--	ds500¹		2		CSA WA	120
rs112527025^1,2	C,	--	160099976(+)	`CTTTTA/CGGTTA`	2	--	ds500¹		2		NA	122
rs2842980^1,2	C,F,A,H,	--	160100116(-)	`AAAACA/TTTAAA`	2	--	ds500¹		34		NA NS EA WA CSA	3175
rs7855^1,2	C,F,H,	--	160100302(+)	`AGGACA/GTTATC`	2	--	ut3¹		15		MN NS EA NA	1796
rs192672971^1,2		--	160100625(+)	`ACAGAC/TAGAAT`	2	--	int¹		0	--	--	--	--
rs8031^1,2	C,F,O,A,H,	--	160100640(-)	`AATACT/AGTTTT`	2	--	int¹		34		MN EA NA NS WA CSA	4759
rs73599328^1,2	C,	--	160100734(+)	`TCAGTC/TACAAA`	2	--	int¹		2		WA	120

HapMap Linkage Disequilibrium report for SOD2 (160100096 - 160183561 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SOD2
1 CNV: 3647
1 Indel: 11272
Human Gene Mutation Database (HGMD): SOD2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOD2

DNA2.0 Custom Variant and Variant Library Synthesis for SOD2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SOD2 for disorders           About GeneDecksing

OMIM gene information: 147460
OMIM disorders: 612634
UniProtKB/Swiss-Prot: SODM_HUMAN, P04179

Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6

(MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence

of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and

diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is

characterized by vascular permeability and increased tissue ischemia and angiogenesis

20/247 diseases for SOD2 (see all 247): About MalaCards

motor neuron disease spermatic cord torsion microvascular complications of diabetes 6 extrinsic allergic alveolitis

cardiomyopathy hypersensitivity reaction type ii disease leber hereditary optic neuropathy mitochondrial complex i deficiency

mitochondrial encephalomyopathy age related macular degeneration iron overload non-small cell lung carcinoma

amyotrophic lateral sclerosis spinocerebellar ataxia type 3 barrett's esophagus multiple chemical sensitivity

friedreich ataxia malignant mesothelioma testicular germ cell tumor malignant pleural mesothelioma

2 diseases from the University of Copenhagen DISEASES database for SOD2:

Cancer Vascular disease

10/92 Novoseek disease relationships for SOD2 gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	58.7	129	20514411 (4), 1960995 (3), 2406241 (2), 2222450 (2) (see all 75)
tumors	54.5	432	12469139 (8), 10919671 (6), 1988135 (6), 7780953 (4) (see all 99)
amyotrophic lateral sclerosis	49	18	7985495 (2), 9452823 (2), 7699393 (1), 7719145 (1) (see all 12)
cancer	47.5	158	19074833 (5), 19405048 (4), 19467856 (4), 9926924 (3) (see all 87)
cell damage	42.9	10	11729237 (3), 7524486 (1), 20107204 (1), 8360707 (1) (see all 7)
neurodegenerative diseases	42	4	10762167 (1), 8334770 (1), 12618592 (1)
neurodegeneration	40.1	3	17251466 (1), 16485861 (1), 14681883 (1)
shock	35.5	46	15128298 (2), 1337859 (2), 7514009 (2), 8144583 (1) (see all 31)
breast cancer	35.1	148	15386537 (5), 15184255 (5), 16945136 (4), 17965603 (4) (see all 49)
merrf	34.2	3	11403514 (1), 11907800 (1)

Genetic Association Database (GAD): SOD2
Human Genome Epidemiology (HuGE) Navigator: SOD2 (302 documents)

Export disorders for SOD2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SOD2 gene, integrated from 9 sources (see all 1617):
(articles sorted by number of sources associating them with SOD2)

Utopia: connect your pdf to the dynamic
world of online information

The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients. (PubMed id 12624725)^{1, 2, 4, 9} Nomiyama T....Kawamori R. (2003)
Complementary DNA encoding human colon cancer manganese superoxide dismutase and the expression of its gene in human cells. (PubMed id 1988135)^{1, 2, 9} St Clair D.K. and Holland J.C. (1991)
Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women. (PubMed id 15883815)^{1, 4, 9} Bergman M....Wingren S. (2005)
Manganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland). (PubMed id 12948282)^{1, 4, 9} Woodson K....Albanes D. (2003)
Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility. (PubMed id 15386537)^{1, 4, 9} Kocabas N.A....Karakaya A.E. (2005)
Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis. (PubMed id 16157826)^{1, 4, 9} Stickel F....Schuppan D. (2005)
Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk. (PubMed id 11323405)^{1, 4, 9} Mitrunen K....Hirvonen A. (2001)
Manganese superoxide dismutase gene polymorphism (V16A) is associated with stages of albuminuria in Korean type 2 diabetic patients. (PubMed id 16324912)^{1, 4, 9} Lee S.J....Kim T.W. (2006)
Oxidative stress-related gene polymorphism and the risk of preeclampsia. (PubMed id 15734083)^{1, 4, 9} Kim Y.J....Pang M.G. (2005)
Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancer. (PubMed id 15184255)^{1, 4, 9} Tamimi R.M....Hunter D.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6648	HGNC: 11180	AceView: SOD2	Ensembl:ENSG00000112096	euGenes: HUgn6648
ECgene: SOD2	Kegg: 6648	H-InvDB: SOD2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SOD2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SOD2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/sod2/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=SOD2
Wikipedia	http://en.wikipedia.org/wiki/Superoxide_dismutase

Intellectual Property for SOD2 gene
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Patent Information for SOD2 gene:
Search GeneIP for patents involving SOD2

GeneCards and IP:
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SOD2 Gene

superoxide dismutase 2, mitochondrial

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