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Aliases for SOD1 Gene

Aliases for SOD1 Gene

  • Superoxide Dismutase 1, Soluble 2 3
  • EC 4 63
  • HSod1 3 4
  • Amyotrophic Lateral Sclerosis 1 (Adult) 2
  • Epididymis Secretory Protein Li 44 3
  • Superoxide Dismutase, Cystolic 3
  • Cu/Zn Superoxide Dismutase 3
  • Superoxide Dismutase 1 4
  • Indophenoloxidase A 3
  • SOD, Soluble 3
  • Homodimer 3
  • HEL-S-44 3
  • IPOA 3
  • ALS1 3
  • SOD 3
  • ALS 3

External Ids for SOD1 Gene

Previous HGNC Symbols for SOD1 Gene

  • ALS
  • ALS1

Previous GeneCards Identifiers for SOD1 Gene

  • GC21P029609
  • GC21P031952
  • GC21P031953
  • GC21P033031
  • GC21P018441

Summaries for SOD1 Gene

Entrez Gene Summary for SOD1 Gene

  • The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOD1 Gene

SOD1 (Superoxide Dismutase 1, Soluble) is a Protein Coding gene. Diseases associated with SOD1 include sod1-related amyotrophic lateral sclerosis and amyotrophic lateral sclerosis 1. Among its related pathways are Hemostasis and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is CCS.

UniProtKB/Swiss-Prot for SOD1 Gene

  • Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Gene Wiki entry for SOD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOD1 Gene

Genomics for SOD1 Gene

Regulatory Elements for SOD1 Gene

Genomic Location for SOD1 Gene

31,659,622 bp from pter
31,668,931 bp from pter
9,310 bases
Plus strand

Genomic View for SOD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOD1 Gene

Proteins for SOD1 Gene

  • Protein details for SOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Superoxide dismutase [Cu-Zn]
    Protein Accession:
    Secondary Accessions:
    • A6NHJ0
    • D3DSE4
    • Q16669
    • Q16711
    • Q16838
    • Q16839
    • Q16840
    • Q6NR85

    Protein attributes for SOD1 Gene

    154 amino acids
    Molecular mass:
    15936 Da
    Name=Cu cation; Xref=ChEBI:CHEBI:23378; Note=Binds 1 copper ion per subunit.;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not.
    • The protein (both wild-type and ALS1 variants) has a tendency to form fibrillar aggregates in the absence of the intramolecular disulfide bond or of bound zinc ions. These aggregates may have cytotoxic effects. Zinc binding promotes dimerization and stabilizes the native form

    Three dimensional structures from OCA and Proteopedia for SOD1 Gene

neXtProt entry for SOD1 Gene

Proteomics data for SOD1 Gene at MOPED

Post-translational modifications for SOD1 Gene

  • Palmitoylation helps nuclear targeting and decreases catalytic activity.
  • Succinylation, adjacent to copper catalytic site probably inhibit activity. Desuccinylated by SIRT5, enhancing activity.
  • The ditryptophan cross-link at Trp-33 is responsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required.
  • Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
  • Ubiquitination at Lys 31 and Lys 123
  • Modification sites at PhosphoSitePlus

Other Protein References for SOD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SOD1 (SOD1/Cu-Zn SOD)
  • Cell Signaling Technology (CST) Antibodies for SOD1 (SOD1)

Domains & Families for SOD1 Gene

Protein Domains for SOD1 Gene

Suggested Antigen Peptide Sequences for SOD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Cu-Zn superoxide dismutase family.
  • Belongs to the Cu-Zn superoxide dismutase family.
genes like me logo Genes that share domains with SOD1: view

No data available for Gene Families for SOD1 Gene

Function for SOD1 Gene

Molecular function for SOD1 Gene

GENATLAS Biochemistry:
copper/zinc superoxide dismutase 1,soluble,catabolic pathway of activated oxygen species,free radical detoxification,involved in the function of motor neuron,regulated by SP1,EGR1 and WT1
UniProtKB/Swiss-Prot CatalyticActivity:
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
UniProtKB/Swiss-Prot Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Enzyme Numbers (IUBMB) for SOD1 Gene

Gene Ontology (GO) - Molecular Function for SOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004784 superoxide dismutase activity TAS --
GO:0005507 copper ion binding IDA 17008312
GO:0005515 protein binding IPI 16369483
GO:0008270 zinc ion binding IDA 17381088
GO:0019899 enzyme binding --
genes like me logo Genes that share ontologies with SOD1: view
genes like me logo Genes that share phenotypes with SOD1: view

Animal Models for SOD1 Gene

MGI Knock Outs for SOD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SOD1 SOD1 - 2148

miRNA for SOD1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOD1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for SOD1 Gene

Localization for SOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOD1 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.

Subcellular locations from

Jensen Localization Image for SOD1 Gene COMPARTMENTS Subcellular localization image for SOD1 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
peroxisome 5
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 2
lysosome 2
plasma membrane 2
vacuole 2

Gene Ontology (GO) - Cellular Components for SOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 7172448
GO:0005634 nucleus IDA 1332049
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 1332049
genes like me logo Genes that share ontologies with SOD1: view

Pathways & Interactions for SOD1 Gene

genes like me logo Genes that share pathways with SOD1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for SOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity ISS --
GO:0000302 response to reactive oxygen species TAS --
GO:0000303 response to superoxide IDA 16790527
GO:0001541 ovarian follicle development ISS --
GO:0001819 positive regulation of cytokine production IDA 15544046
genes like me logo Genes that share ontologies with SOD1: view

No data available for SIGNOR curated interactions for SOD1 Gene

Drugs & Compounds for SOD1 Gene

(61) Drugs for SOD1 Gene - From: NovoSeek, HMDB, DGIdb, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved Nutra Enzyme, inducer 350,355
Zinc Approved Pharma 1404
Carboplatin Approved Pharma Enzyme Antitumor agent that forms platinum-DNA adducts., Platinum 1812
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 1276

(96) Additional Compounds for SOD1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
  • Dioxidanidyl
  • Dioxide(1-)
  • Hyperoxid
  • Superoxide
  • Superoxide anion
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with SOD1: view

Transcripts for SOD1 Gene

mRNA/cDNA for SOD1 Gene

Unigene Clusters for SOD1 Gene

Superoxide dismutase 1, soluble:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6: - - - - -
SP8: - -

Relevant External Links for SOD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOD1 Gene

mRNA expression in normal human tissues for SOD1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOD1 Gene

SOURCE GeneReport for Unigene cluster for SOD1 Gene Hs.443914

genes like me logo Genes that share expression patterns with SOD1: view

Protein tissue co-expression partners for SOD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SOD1 Gene

Orthologs for SOD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SOD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SOD1 35
  • 85.31 (n)
  • 82.89 (a)
-- 36
  • 83 (a)
SOD1 36
  • 83 (a)
(Canis familiaris)
Mammalia SOD1 35
  • 86.49 (n)
  • 81.58 (a)
SOD1 36
  • 74 (a)
(Mus musculus)
Mammalia Sod1 35
  • 83.77 (n)
  • 83.77 (a)
Sod1 16
Sod1 36
  • 84 (a)
(Pan troglodytes)
Mammalia SOD1 35
  • 99.78 (n)
  • 100 (a)
SOD1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sod1 35
  • 84.42 (n)
  • 83.12 (a)
(Monodelphis domestica)
Mammalia SOD1 36
  • 80 (a)
(Gallus gallus)
Aves SOD1 35
  • 75.66 (n)
  • 75.66 (a)
SOD1 36
  • 73 (a)
(Anolis carolinensis)
Reptilia SOD1 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sod1 35
  • 66.44 (n)
  • 69.33 (a)
Str.1999 35
African clawed frog
(Xenopus laevis)
Amphibia sod1-A-prov 35
(Danio rerio)
Actinopterygii sod1 35
  • 67.97 (n)
  • 70.13 (a)
sod1 36
  • 70 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9641 35
fruit fly
(Drosophila melanogaster)
Insecta CG9027 37
  • 55 (a)
Sod 37
  • 61 (a)
Sod 35
  • 55.84 (n)
  • 61.04 (a)
Sod 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta CUSOD3 35
  • 59.65 (n)
  • 59.21 (a)
(Caenorhabditis elegans)
Secernentea sod-1 37
  • 56 (a)
sod-4 37
  • 54 (a)
ZK430.3 37
  • 54 (a)
sod-1 35
  • 55.26 (n)
  • 57.89 (a)
sod-4 36
  • 33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL321W 35
  • 54.08 (n)
  • 57.62 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05567g 35
  • 54.44 (n)
  • 58.67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOD1 35
  • 57.05 (n)
  • 56.38 (a)
SOD1 36
  • 55 (a)
SOD1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CSD1 35
  • 56.31 (n)
  • 54.73 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3600 35
(Oryza sativa)
Liliopsida Os07g0665200 35
  • 59.46 (n)
  • 60.81 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02133 35
  • 52.98 (n)
  • 55.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sod1 35
  • 55.56 (n)
  • 56.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5360 36
  • 54 (a)
Species with no ortholog for SOD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOD1 Gene

Gene Tree for SOD1 (if available)
Gene Tree for SOD1 (if available)

Paralogs for SOD1 Gene

Paralogs for SOD1 Gene

(2) SIMAP similar genes for SOD1 Gene using alignment to 4 proteins: Pseudogenes for SOD1 Gene

genes like me logo Genes that share paralogs with SOD1: view

Variants for SOD1 Gene

Sequence variations from dbSNP and Humsavar for SOD1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
VAR_007130 Amyotrophic lateral sclerosis 1 (ALS1)
VAR_007131 Amyotrophic lateral sclerosis 1 (ALS1)
VAR_007132 Amyotrophic lateral sclerosis 1 (ALS1)
VAR_007133 Amyotrophic lateral sclerosis 1 (ALS1)
VAR_007134 Amyotrophic lateral sclerosis 1 (ALS1)

Structural Variations from Database of Genomic Variants (DGV) for SOD1 Gene

Variant ID Type Subtype PubMed ID
nsv519899 CNV Gain 19592680
nsv834079 CNV Loss 17160897

Variation tolerance for SOD1 Gene

Residual Variation Intolerance Score: 42.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOD1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOD1 Gene

Disorders for SOD1 Gene

MalaCards: The human disease database

(56) MalaCards diseases for SOD1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
sod1-related amyotrophic lateral sclerosis
  • fals
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
acid-labile subunit, deficiency of
  • acid-labile subunit deficiency
eales disease
  • idiopathic obliterative vasculopathy
- elite association
Search SOD1 in MalaCards View complete list of genes associated with diseases


  • Amyotrophic lateral sclerosis 1 (ALS1) [MIM:105400]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:10430435, ECO:0000269 PubMed:10732812, ECO:0000269 PubMed:11369193, ECO:0000269 PubMed:11535232, ECO:0000269 PubMed:12402272, ECO:0000269 PubMed:14506936, ECO:0000269 PubMed:21220647, ECO:0000269 PubMed:21247266, ECO:0000269 PubMed:7496169, ECO:0000269 PubMed:7501156, ECO:0000269 PubMed:7647793, ECO:0000269 PubMed:7655468, ECO:0000269 PubMed:7655469, ECO:0000269 PubMed:7655471, ECO:0000269 PubMed:7700376, ECO:0000269 PubMed:7795609, ECO:0000269 PubMed:7836951, ECO:0000269 PubMed:7870076, ECO:0000269 PubMed:7881433, ECO:0000269 PubMed:7887412, ECO:0000269 PubMed:7951252, ECO:0000269 PubMed:7980516, ECO:0000269 PubMed:7997024, ECO:0000269 PubMed:8069312, ECO:0000269 PubMed:8179602, ECO:0000269 PubMed:8351519, ECO:0000269 PubMed:8446170, ECO:0000269 PubMed:8528216, ECO:0000269 PubMed:8682505, ECO:0000269 PubMed:8907321, ECO:0000269 PubMed:8938700, ECO:0000269 PubMed:8990014, ECO:0000269 PubMed:9101297, ECO:0000269 PubMed:9131652, ECO:0000269 PubMed:9455977}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SOD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SOD1: view

No data available for Genatlas for SOD1 Gene

Publications for SOD1 Gene

  1. Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naA^ve and treated Crohn's disease. (PMID: 19637347) BeltrA!n B. … Ponce J. (Inflamm. Bowel Dis. 2010) 23 67
  2. Influence of estrogens on copper indicators: in vivo and in vitro studies. (PMID: 19685012) Arredondo M. … Araya M. (Biol Trace Elem Res 2010) 23 67
  3. Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activation. (PMID: 19804834) Chiu W.T. … Chen Y.C. (Neurobiol. Dis. 2010) 23 67
  4. Evaluation of oxidant-antioxidant balance in patients on maintenance haemodialysis: a comparative study of dialyzers membranes. (PMID: 19816045) MacA-as NA_A+ez J.F. … Sousa F. (Nephron Clin Pract 2010) 23 67
  5. Bifenthrin-induced oxidative stress in human erythrocytes in vitro and protective effect of selected flavonols. (PMID: 19833193) Sadowska-Woda I. … Karowicz-BiliA8ska A. (Toxicol In Vitro 2010) 23 67

Products for SOD1 Gene

Sources for SOD1 Gene

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