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Aliases for SOD1 Gene

Aliases for SOD1 Gene

  • Superoxide Dismutase 1 2 3 4 5
  • Superoxide Dismutase 1, Soluble 2 3
  • EC 1.15.1.1 4 61
  • HSod1 3 4
  • Amyotrophic Lateral Sclerosis 1 (Adult) 2
  • Epididymis Secretory Protein Li 44 3
  • Superoxide Dismutase, Cystolic 3
  • Superoxide Dismutase [Cu-Zn] 3
  • Cu/Zn Superoxide Dismutase 3
  • Indophenoloxidase A 3
  • SOD, Soluble 3
  • Homodimer 3
  • HEL-S-44 3
  • IPOA 3
  • ALS1 3
  • ALS 3
  • SOD 3

External Ids for SOD1 Gene

Previous HGNC Symbols for SOD1 Gene

  • ALS
  • ALS1

Previous GeneCards Identifiers for SOD1 Gene

  • GC21P029609
  • GC21P031952
  • GC21P031953
  • GC21P033031
  • GC21P018441

Summaries for SOD1 Gene

Entrez Gene Summary for SOD1 Gene

  • The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOD1 Gene

SOD1 (Superoxide Dismutase 1) is a Protein Coding gene. Diseases associated with SOD1 include Amyotrophic Lateral Sclerosis 1 and Sod1-Related Amyotrophic Lateral Sclerosis. Among its related pathways are Dopamine metabolism and Copper homeostasis. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is CCS.

UniProtKB/Swiss-Prot for SOD1 Gene

  • Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Gene Wiki entry for SOD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOD1 Gene

Genomics for SOD1 Gene

Regulatory Elements for SOD1 Gene

Enhancers for SOD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G031173 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -485.2 -485224 2.2 ATF1 ARNT CREB3L1 TCF12 GATA2 JUNB NCOA1 REST ZNF592 MBD2 LOC102724449 SOD1 ENSG00000238390 TIAM1 LOC150051 GC21P031202 GC21M031017
GH21G031629 0.8 ENCODE 16.8 -29.5 -29512 1.3 NFIB JUN YY1 ZNF324 HIC1 ZNF366 ZNF350 RCOR1 FOSL2 PRDM10 SOD1 LOC102724449 ENSG00000238390 LOC150051 TIAM1 FBXW11P1 GC21P031631
GH21G031714 1.1 Ensembl ENCODE 11.9 +55.3 55332 1.5 HDAC1 HDGF PKNOX1 CBX3 TBL1XR1 ARNT TCF12 GATA2 ZSCAN5C CREM ENSG00000238390 LOC102724449 SOD1 HMGN1P2 GC21P031707 SCAF4
GH21G031710 0.7 ENCODE 11.2 +51.2 51219 0.7 CEBPB FEZF1 TSHZ1 FOXA1 OSR2 ZNF121 JUND PRDM6 ATF3 BCL11A ENSG00000238390 LOC102724449 SOD1 LOC150051 TIAM1 HMGN1P2 GC21P031707 SCAF4
GH21G031730 1.4 FANTOM5 ENCODE 5.5 +72.5 72528 4.1 HDGF PKNOX1 ARNT AGO1 WRNIP1 SIN3A DMAP1 ZNF766 CBX5 ZNF207 MIS18A SOD1 SCAF4 ENSG00000273091
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SOD1 on UCSC Golden Path with GeneCards custom track

Promoters for SOD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000141329 478 2201 PKNOX1 MLX CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for SOD1 Gene

Chromosome:
21
Start:
31,659,622 bp from pter
End:
31,668,931 bp from pter
Size:
9,310 bases
Orientation:
Plus strand

Genomic View for SOD1 Gene

Genes around SOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOD1 Gene

Proteins for SOD1 Gene

  • Protein details for SOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00441-SODC_HUMAN
    Recommended name:
    Superoxide dismutase [Cu-Zn]
    Protein Accession:
    P00441
    Secondary Accessions:
    • A6NHJ0
    • D3DSE4
    • Q16669
    • Q16711
    • Q16838
    • Q16839
    • Q16840
    • Q6NR85

    Protein attributes for SOD1 Gene

    Size:
    154 amino acids
    Molecular mass:
    15936 Da
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not.
    Miscellaneous:
    • The protein (both wild-type and ALS1 variants) has a tendency to form fibrillar aggregates in the absence of the intramolecular disulfide bond or of bound zinc ions. These aggregates may have cytotoxic effects. Zinc binding promotes dimerization and stabilizes the native form.

    Three dimensional structures from OCA and Proteopedia for SOD1 Gene

neXtProt entry for SOD1 Gene

Selected DME Specific Peptides for SOD1 Gene

P00441:
  • AGPHFNP
  • RHVGDLGN
  • INFEQKE
  • KAVCVLKGD
  • TGNAGSRL
  • GGNEESTKTGNA
  • ACGVIGI
  • GRTLVVH
  • GLHGFHVH
  • NGPVKVWGSI
  • RLACGVIG
  • CGVIGIA
  • HEKADDLG
  • DDLGKGGN
  • IEDSVISL

Post-translational modifications for SOD1 Gene

  • Palmitoylation helps nuclear targeting and decreases catalytic activity.
  • Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.
  • The ditryptophan cross-link at Trp-33 is responsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required.
  • Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
  • Ubiquitination at Lys31 and isoforms=123
  • Modification sites at PhosphoSitePlus

Other Protein References for SOD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SOD1 Gene

Protein Domains for SOD1 Gene

Suggested Antigen Peptide Sequences for SOD1 Gene

Graphical View of Domain Structure for InterPro Entry

P00441

UniProtKB/Swiss-Prot:

SODC_HUMAN :
  • Belongs to the Cu-Zn superoxide dismutase family.
Family:
  • Belongs to the Cu-Zn superoxide dismutase family.
genes like me logo Genes that share domains with SOD1: view

No data available for Gene Families for SOD1 Gene

Function for SOD1 Gene

Molecular function for SOD1 Gene

GENATLAS Biochemistry:
copper/zinc superoxide dismutase 1,soluble,catabolic pathway of activated oxygen species,free radical detoxification,involved in the function of motor neuron,regulated by SP1,EGR1 and WT1
UniProtKB/Swiss-Prot CatalyticActivity:
2 superoxide + 2 H(+) = O(2) + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Enzyme Numbers (IUBMB) for SOD1 Gene

Gene Ontology (GO) - Molecular Function for SOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004784 superoxide dismutase activity IEA,TAS --
GO:0005507 copper ion binding IDA 17008312
GO:0005515 protein binding IPI 16369483
GO:0008270 zinc ion binding IDA 17381088
GO:0016209 antioxidant activity IEA --
genes like me logo Genes that share ontologies with SOD1: view
genes like me logo Genes that share phenotypes with SOD1: view

Human Phenotype Ontology for SOD1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SOD1 Gene

MGI Knock Outs for SOD1:

Animal Model Products

miRNA for SOD1 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SOD1

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for SOD1 Gene

Localization for SOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOD1 Gene

Cytoplasm. Mitochondrion. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. {ECO:0000269 PubMed:19741096}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOD1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
peroxisome 5
nucleus 5
cytosol 5
lysosome 3
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for SOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 7172448
GO:0005634 nucleus IEA,IDA 1332049
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 1332049
genes like me logo Genes that share ontologies with SOD1: view

Pathways & Interactions for SOD1 Gene

genes like me logo Genes that share pathways with SOD1: view

Gene Ontology (GO) - Biological Process for SOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity ISS --
GO:0000302 response to reactive oxygen species TAS --
GO:0000303 response to superoxide IDA 16790527
GO:0001541 ovarian follicle development ISS,IEA --
GO:0001819 positive regulation of cytokine production IDA 15544046
genes like me logo Genes that share ontologies with SOD1: view

No data available for SIGNOR curated interactions for SOD1 Gene

Drugs & Compounds for SOD1 Gene

(67) Drugs for SOD1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Enzyme, inducer 414,411
Copper Approved Pharma 181
Oxygen Approved, Vet_approved Pharma 0
Zinc Approved Pharma 2296
Manganese Approved Nutra 34

(90) Additional Compounds for SOD1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
superoxide
  • Dioxidanidyl
  • Dioxide(1-)
  • Hyperoxid
  • Superoxide
  • Superoxide anion
11062-77-4
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with SOD1: view

Transcripts for SOD1 Gene

Unigene Clusters for SOD1 Gene

Superoxide dismutase 1, soluble:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SOD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6: - - - - -
SP7:
SP8: - -

Relevant External Links for SOD1 Gene

GeneLoc Exon Structure for
SOD1
ECgene alternative splicing isoforms for
SOD1

Expression for SOD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOD1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SOD1 Gene



Protein tissue co-expression partners for SOD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SOD1 Gene:

SOD1

SOURCE GeneReport for Unigene cluster for SOD1 Gene:

Hs.443914

Evidence on tissue expression from TISSUES for SOD1 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Intestine(4.6)
  • Lung(4.4)
  • Pancreas(4.4)
  • Eye(4.2)
  • Skin(4)
  • Muscle(3.4)
  • Heart(3.3)
  • Kidney(3.2)
  • Blood(2.9)
  • Spleen(2.5)
  • Adrenal gland(2.4)
  • Thyroid gland(2.3)
  • Bone marrow(2.1)
  • Gall bladder(2.1)
  • Stomach(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SOD1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • epiglottis
  • face
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • skull
  • tongue
  • vocal cord
Thorax:
  • bronchus
  • clavicle
  • esophagus
  • heart
  • lung
  • scapula
  • trachea
Abdomen:
  • biliary tract
  • liver
  • stomach
Limb:
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • shin
  • shoulder
  • thigh
  • toe
  • upper limb
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with SOD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SOD1 Gene

Orthologs for SOD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SOD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOD1 35 34
  • 99.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SOD1 35 34
  • 86.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SOD1 35 34
  • 85.31 (n)
OneToMany
-- 35
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sod1 34
  • 84.42 (n)
mouse
(Mus musculus)
Mammalia Sod1 16 35 34
  • 83.77 (n)
oppossum
(Monodelphis domestica)
Mammalia SOD1 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOD1 35 34
  • 75.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOD1 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sod1 34
  • 66.44 (n)
Str.1999 34
African clawed frog
(Xenopus laevis)
Amphibia sod1-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii sod1 35 34
  • 67.97 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9641 34
African malaria mosquito
(Anopheles gambiae)
Insecta CUSOD3 34
  • 59.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sod 36 34 35
  • 55.84 (n)
CG9027 36
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea sod-1 36 34
  • 55.26 (n)
sod-4 36 35
  • 54 (a)
ZK430.3 36
  • 54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOD1 34 35 37
  • 57.05 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05567g 34
  • 54.44 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL321W 34
  • 54.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons CSD1 34
  • 56.31 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3600 34
rice
(Oryza sativa)
Liliopsida Os07g0665200 34
  • 59.46 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sod1 34
  • 55.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5360 35
  • 54 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU02133 34
  • 52.98 (n)
Species where no ortholog for SOD1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOD1 Gene

ENSEMBL:
Gene Tree for SOD1 (if available)
TreeFam:
Gene Tree for SOD1 (if available)

Paralogs for SOD1 Gene

Paralogs for SOD1 Gene

(2) SIMAP similar genes for SOD1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SOD1 Gene

genes like me logo Genes that share paralogs with SOD1: view

Variants for SOD1 Gene

Sequence variations from dbSNP and Humsavar for SOD1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs11556620 Amyotrophic lateral sclerosis 1 (ALS1) [MIM:105400] 31,667,278(+) GGGCA(A/G)TGTGA reference, missense
rs121912431 Pathogenic, Amyotrophic lateral sclerosis 1 (ALS1) [MIM:105400] 31,663,829(+) TTAAA(A/G)GACTG reference, missense
rs121912432 Pathogenic, Amyotrophic lateral sclerosis 1 (ALS1) [MIM:105400] 31,663,832(+) AAGGA(C/G)TGACT reference, missense
rs121912433 Pathogenic, Amyotrophic lateral sclerosis 1 (ALS1) [MIM:105400] 31,663,841(+) CTGAA(A/G)GCCTG reference, missense
rs121912434 Pathogenic, Amyotrophic lateral sclerosis 1 (ALS1) [MIM:105400] 31,663,842(+) TGAAG(A/G)CCTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SOD1 Gene

Variant ID Type Subtype PubMed ID
esv3575385 CNV gain 25503493
nsv1067151 CNV gain 25217958
nsv519899 CNV gain 19592680
nsv834079 CNV loss 17160897

Variation tolerance for SOD1 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOD1 Gene

Human Gene Mutation Database (HGMD)
SOD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOD1 Gene

Disorders for SOD1 Gene

MalaCards: The human disease database

(51) MalaCards diseases for SOD1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
sod1-related amyotrophic lateral sclerosis
  • fals
lateral sclerosis
  • motor neuron disease
motor neuron disease
  • motor neuron diseases
eales disease
  • idiopathic obliterative vasculopathy
- elite association - COSMIC cancer census association via MalaCards
Search SOD1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SODC_HUMAN
  • Amyotrophic lateral sclerosis 1 (ALS1) [MIM:105400]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:10400992, ECO:0000269 PubMed:10430435, ECO:0000269 PubMed:10732812, ECO:0000269 PubMed:11369193, ECO:0000269 PubMed:11535232, ECO:0000269 PubMed:12145308, ECO:0000269 PubMed:12402272, ECO:0000269 PubMed:12754496, ECO:0000269 PubMed:12963370, ECO:0000269 PubMed:14506936, ECO:0000269 PubMed:15056757, ECO:0000269 PubMed:18301754, ECO:0000269 PubMed:18378676, ECO:0000269 PubMed:18552350, ECO:0000269 PubMed:19741096, ECO:0000269 PubMed:21220647, ECO:0000269 PubMed:21247266, ECO:0000269 PubMed:27604643, ECO:0000269 PubMed:7496169, ECO:0000269 PubMed:7501156, ECO:0000269 PubMed:7647793, ECO:0000269 PubMed:7655468, ECO:0000269 PubMed:7655469, ECO:0000269 PubMed:7655471, ECO:0000269 PubMed:7700376, ECO:0000269 PubMed:7795609, ECO:0000269 PubMed:7836951, ECO:0000269 PubMed:7870076, ECO:0000269 PubMed:7881433, ECO:0000269 PubMed:7887412, ECO:0000269 PubMed:7951252, ECO:0000269 PubMed:7980516, ECO:0000269 PubMed:7997024, ECO:0000269 PubMed:8069312, ECO:0000269 PubMed:8179602, ECO:0000269 PubMed:8351519, ECO:0000269 PubMed:8446170, ECO:0000269 PubMed:8528216, ECO:0000269 PubMed:8682505, ECO:0000269 PubMed:8907321, ECO:0000269 PubMed:8938700, ECO:0000269 PubMed:8990014, ECO:0000269 PubMed:9101297, ECO:0000269 PubMed:9131652, ECO:0000269 PubMed:9455977, ECO:0000269 PubMed:9541385}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SOD1

Genetic Association Database (GAD)
SOD1
Human Genome Epidemiology (HuGE) Navigator
SOD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOD1
genes like me logo Genes that share disorders with SOD1: view

No data available for Genatlas for SOD1 Gene

Publications for SOD1 Gene

  1. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. (PMID: 8446170) Rosen D.R. … Brown R.H. Jr. (Nature 1993) 2 3 4 46 64
  2. Age and founder effect of SOD1 A4V mutation causing ALS. (PMID: 19176896) Saeed M. … Siddique T. (Neurology 2009) 3 22 46 64
  3. Diffusion tensor imaging in sporadic and familial (D90A SOD1) forms of amyotrophic lateral sclerosis. (PMID: 19139308) Stanton B.R. … Simmons A. (Arch. Neurol. 2009) 3 22 46 64
  4. Further evidence that D90A-SOD1 mutation is recessively inherited in ALS patients in Italy. (PMID: 18608106) Luisa Conforti F. … Quattrone A. (Amyotroph Lateral Scler 2009) 3 22 46 64
  5. DNA sequence analysis of the conserved region around the SOD1 gene locus in recessively inherited ALS. (PMID: 19596401) Broom W.J. … Brown R.H. (Neurosci. Lett. 2009) 3 22 46 64

Products for SOD1 Gene

Sources for SOD1 Gene

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