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Aliases for SOCS7 Gene

Aliases for SOCS7 Gene

  • Suppressor Of Cytokine Signaling 7 2 3
  • Nck, Ash And Phospholipase C Gamma-Binding Protein 3 4
  • NCK-Associated Protein 4 2 3
  • SOCS-7 3 4
  • NAP-4 3 4
  • NAP4 3 4
  • Nck, Ash And Phospholipase C Binding Protein 3
  • Ash And Phospholipase C Binding Protein 2
  • Nck-Associated Protein 4 4
  • NCKAP4 3
  • SOCS6 4
  • Nck 2

External Ids for SOCS7 Gene

Summaries for SOCS7 Gene

GeneCards Summary for SOCS7 Gene

SOCS7 (Suppressor Of Cytokine Signaling 7) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include SH3 domain binding.

UniProtKB/Swiss-Prot for SOCS7 Gene

  • Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Gene Wiki entry for SOCS7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS7 Gene

Genomics for SOCS7 Gene

Genomic Location for SOCS7 Gene

Start:
38,352,124 bp from pter
End:
38,405,593 bp from pter
Size:
53,470 bases
Orientation:
Plus strand

Genomic View for SOCS7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOCS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS7 Gene

Regulatory Elements for SOCS7 Gene

Proteins for SOCS7 Gene

  • Protein details for SOCS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14512-SOCS7_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 7
    Protein Accession:
    O14512
    Secondary Accessions:
    • A2VCU2
    • Q0IJ63

    Protein attributes for SOCS7 Gene

    Size:
    581 amino acids
    Molecular mass:
    62969 Da
    Quaternary structure:
    • Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6.
    SequenceCaution:
    • Sequence=AAI28608.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence.; Evidence={ECO:0000305}; Sequence=BAA22432.1; Type=Erroneous termination; Positions=582; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for SOCS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOCS7 Gene

Proteomics data for SOCS7 Gene at MOPED

Post-translational modifications for SOCS7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOCS7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOCS7 Gene

Domains for SOCS7 Gene

Gene Families for SOCS7 Gene

HGNC:
  • SH2D :SH2 domain containing
  • SOCS :Suppressors of cytokine signaling

Protein Domains for SOCS7 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SOCS7_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.:
    • O14512
  • Contains 1 SH2 domain.:
    • O14512
  • Contains 1 SOCS box domain.:
    • O14512
genes like me logo Genes that share domains with SOCS7: view

Function for SOCS7 Gene

Molecular function for SOCS7 Gene

UniProtKB/Swiss-Prot Function: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
UniProtKB/Swiss-Prot Induction: By IL6/interleukin-6, prolactin and growth hormone.

Gene Ontology (GO) - Molecular Function for SOCS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005515 protein binding IPI 17803907
GO:0017124 SH3 domain binding NAS 9344857
genes like me logo Genes that share ontologies with SOCS7: view
genes like me logo Genes that share phenotypes with SOCS7: view

Animal Models for SOCS7 Gene

MGI Knock Outs for SOCS7:

miRNA for SOCS7 Gene

miRTarBase miRNAs that target SOCS7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SOCS7 Gene

Localization for SOCS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOCS7 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOCS7 Gene COMPARTMENTS Subcellular localization image for SOCS7 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SOCS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SOCS7: view

Pathways for SOCS7 Gene

genes like me logo Genes that share pathways with SOCS7: view

UniProtKB/Swiss-Prot O14512-SOCS7_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SOCS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0008150 biological_process ND --
GO:0008286 insulin receptor signaling pathway IEA --
GO:0009968 negative regulation of signal transduction --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with SOCS7: view

Transcripts for SOCS7 Gene

mRNA/cDNA for SOCS7 Gene

Unigene Clusters for SOCS7 Gene

Suppressor of cytokine signaling 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: - -

Relevant External Links for SOCS7 Gene

GeneLoc Exon Structure for
SOCS7
ECgene alternative splicing isoforms for
SOCS7

Expression for SOCS7 Gene

mRNA expression in normal human tissues for SOCS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOCS7 Gene

This gene is overexpressed in Testis (17.9) and Brain - Cerebellar Hemisphere (4.4).

SOURCE GeneReport for Unigene cluster for SOCS7 Gene Hs.514132

mRNA Expression by UniProt/SwissProt for SOCS7 Gene

O14512-SOCS7_HUMAN
Tissue specificity: Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.
genes like me logo Genes that share expressions with SOCS7: view

Orthologs for SOCS7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SOCS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOCS7 36
  • 99.91 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SOCS7 36
  • 94.57 (n)
  • 97.23 (a)
dog
(Canis familiaris)
Mammalia SOCS7 36
  • 94 (n)
  • 96.21 (a)
mouse
(Mus musculus)
Mammalia Socs7 36
  • 91.12 (n)
  • 96.89 (a)
Socs7 16
rat
(Rattus norvegicus)
Mammalia Socs7 36
  • 91.58 (n)
  • 97.54 (a)
chicken
(Gallus gallus)
Aves SOCS7 36
  • 83.97 (n)
  • 92.41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia socs7 36
  • 74 (n)
  • 82.61 (a)
Str.2599 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10743 36
zebrafish
(Danio rerio)
Actinopterygii LOC100538186 36
  • 68.09 (n)
  • 74.4 (a)
Species with no ortholog for SOCS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOCS7 Gene

ENSEMBL:
Gene Tree for SOCS7 (if available)
TreeFam:
Gene Tree for SOCS7 (if available)

Paralogs for SOCS7 Gene

Selected SIMAP similar genes for SOCS7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SOCS7: view

No data available for Paralogs for SOCS7 Gene

Variants for SOCS7 Gene

Sequence variations from dbSNP and Humsavar for SOCS7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1045638 -- 38,401,285(+) TATTA(C/T)CAACT utr-variant-3-prime
rs2241673 -- 38,395,668(+) AGTCT(C/G)TAGGA intron-variant
rs3193291 -- 38,399,667(+) GTACT(C/T)TGCGT utr-variant-3-prime
rs3748723 -- 38,402,356(-) ACCTG(C/T)TCCTC utr-variant-3-prime
rs3748724 -- 38,401,998(-) GGTGC(A/G)GAGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SOCS7 Gene

Variant ID Type Subtype PubMed ID
dgv957e1 CNV Complex 17122850
esv33106 CNV Gain 17666407
nsv2041 CNV Insertion 18451855
esv1229884 CNV Deletion 17803354
esv2715897 CNV Deletion 23290073
esv1311253 CNV Deletion 17803354
nsv469701 CNV Loss 16826518
dgv959e1 CNV Complex 17122850

Relevant External Links for SOCS7 Gene

HapMap Linkage Disequilibrium report
SOCS7

Disorders for SOCS7 Gene

(1) University of Copenhagen DISEASES for SOCS7 Gene

Relevant External Links for SOCS7

Human Genome Epidemiology (HuGE) Navigator
SOCS7
genes like me logo Genes that share disorders with SOCS7: view

No data available for UniProtKB/Swiss-Prot for SOCS7 Gene

Publications for SOCS7 Gene

  1. Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines. (PMID: 10969179) Dogusan Z. … Hooghe R. (J. Neuroimmunol. 2000) 3 4 23
  2. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PMID: 15677474) Martens N. … Gertler A. (J. Biol. Chem. 2005) 3 4 23
  3. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PMID: 9344857) Matuoka K. … Takenawa T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4
  4. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  5. The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. (PMID: 15242778) Martens N. … Hooghe-Peters E.L. (Exp. Cell Res. 2004) 3 4

Products for SOCS7 Gene

Sources for SOCS7 Gene

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