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SOCS7 Gene

protein-coding   GIFtS: 57
GCID: GC17P036508

Suppressor Of Cytokine Signaling 7

  Search for SOCS7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Cytokine Signaling 71 2     Nck1
Nck-Associated Protein 41 2 3     Ash And Phospholipase C Binding Protein1
Nck, Ash And Phospholipase C Gamma-Binding Protein2 3     NCKAP42
NAP-42 3     Nck, Ash And Phospholipase C Binding Protein2
NAP42 3     SOCS63
SOCS-72 3     

External Ids:    HGNC: 298461   Entrez Gene: 308372   Ensembl: ENSG000001741117   OMIM: 6087885   UniProtKB: O145123   

Export aliases for SOCS7 gene to outside databases

Previous GC identifers: GC14P049305 GC14P053483 GC17P036869 GC17P033761 GC17P032304


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SOCS7 Gene:
SOCS7 (suppressor of cytokine signaling 7) is a protein-coding gene. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is SOCS3.

UniProtKB/Swiss-Prot: SOCS7_HUMAN, O14512
Function: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in
insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation.
Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation,
sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of
a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal
degradation of target proteins (By similarity)

Gene Wiki entry for SOCS7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NT_187614.1  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOCS7 gene promoter:
         MAZR   ATF-2   GATA-1   Egr-2   POU2F1   POU2F1a   STAT3   c-Myb   SEF-1 (1)   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOCS7 promoter sequence
   Search Chromatin IP Primers for SOCS7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOCS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q21.1

SOCS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P036508:  view genomic region     (about GC identifiers)

Start:
36,508,007 bp from pter      End:
36,561,846 bp from pter
Size:
53,840 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003315948 135,391-189,231     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SOCS7_HUMAN, O14512 (See protein sequence)
Recommended Name: Suppressor of cytokine signaling 7  
Size: 581 amino acids; 62969 Da
Subunit: Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts, via the third proline-rich
region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1,
SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6
Sequence caution: Sequence=AAI28608.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus
may be contaminated with vector sequence; Sequence=BAA22432.1; Type=Erroneous termination; Positions=582;
Note=Translated as stop;
Secondary accessions: A2VCU2 Q0IJ63
Alternative splicing: 2 isoforms:  O14512-1   O14512-2   

Explore the universe of human proteins at neXtProt for SOCS7: NX_O14512

Explore proteomics data for SOCS7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOCS7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055413.1  
    ENSEMBL proteins: 
     ENSP00000330659   ENSP00000464034   ENSP00000462569  

    SOCS7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SOCS7

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SOCS: Suppressors of cytokine signaling
    SH2D: SH2 domain containing

    4 InterPro protein domains:
     IPR001496 SOCS_C
     IPR000980 SH2
     IPR028423 SOCS7
     IPR028413 SOCS

    Graphical View of Domain Structure for InterPro Entry O14512

    ProtoNet protein and cluster: O14512

    1 Blocks protein domain: IPB001496 SOCS protein

    UniProtKB/Swiss-Prot: SOCS7_HUMAN, O14512
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal
    degradation
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SOCS box domain


    Find genes that share domains with SOCS7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOCS7_HUMAN, O14512
    Function: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in
    insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation.
    Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation,
    sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of
    a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal
    degradation of target proteins (By similarity)
    Induction: By IL6/interleukin-6, prolactin and growth hormone

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17803907
    GO:0017124SH3 domain binding NAS9344857
         
    Find genes that share ontologies with SOCS7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SOCS7:
     Decreased viability with pacli 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Socs7):
     behavior/neurological  cardiovascular system  craniofacial  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  mortality/aging  nervous system  skeleton 

    Find genes that share phenotypes with SOCS7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SOCS7: Socs7tm1Wsa Socs7tm1Pbro

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOCS7
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOCS7

    miRNA
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    miRTarBase miRNAs that target SOCS7:
    hsa-mir-615-3p (MIRT040011), hsa-mir-145-5p (MIRT007248)

    Block miRNA regulation of human, mouse, rat SOCS7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOCS7 (see all 152):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-199a-3p hsa-miR-938 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSOCS7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SOCS7

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SOCS7_HUMAN, O14512: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
    Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus
    after UV irradiation. Cytoplasmic location depends upon SEPT7 presence
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with SOCS7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOCS7 About    
    See pathways by source

    SuperPathContained pathways About
    1Prolactin Signaling Pathway
    Leptin signaling pathway0.35
    Prolactin signaling pathway0.33
    2Jak-STAT signaling pathway
    Jak-STAT signaling pathway


    Find genes that share SuperPaths with SOCS7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOCS7
        IL-9 Pathway

    1 BioSystems Pathway for SOCS7
        Leptin signaling pathway


    2 Kegg Pathways  (Kegg details for SOCS7):
        Jak-STAT signaling pathway
    Prolactin signaling pathway

    UniProtKB/Swiss-Prot: SOCS7_HUMAN, O14512
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SOCS7
    Interactions:

        Search GeneGlobe Interaction Network for SOCS7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SOCS7 (O145121, 2, 3 ENSP000003306594) via UniProtKB, MINT, STRING, and/or I2D (see all 61)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI1Q8IZP01, 2, 3, ENSP000003653124EBI-1539606,EBI-375446 MINT-7908139 MINT-7908538 I2D: score=1 STRING: ENSP00000365312
    SORBS3O605042, 3, ENSP000002401234MINT-56622 MINT-56620 MINT-56615 I2D: score=2 STRING: ENSP00000240123
    SEPT6Q141411, 3, ENSP000003415244EBI-1539617,EBI-745901 I2D: score=2 STRING: ENSP00000341524
    IRS2Q9Y4H23, ENSP000003650164I2D: score=1 STRING: ENSP00000365016
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0008286insulin receptor signaling pathway IEA--
    GO:0009968negative regulation of signal transduction IEA--
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    Find genes that share ontologies with SOCS7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOCS7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOCS7 gene: 
    NM_014598.3  

    Unigene Cluster for SOCS7:

    Suppressor of cytokine signaling 7
    Hs.514132  [show with all ESTs]
    Unigene Representative Sequence: NM_014598
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331159 ENST00000577233(uc002hqa.3 uc010cvl.3) ENST00000584132(uc002hqb.3)
    ENST00000580660
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SOCS7 (see all 152):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-199a-3p hsa-miR-938 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-298
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      QuantiFast Probe-based Assays in human, mouse, rat SOCS7

    Additional mRNA sequence: 

    AB005216.1 AK094338.1 BC121030.1 BC121031.1 BC128607.1 

    4 DOTS entries:

    DT.413889  DT.95264284  DT.92418134  DT.75102249 

    Selected AceView cDNA sequences (see all 186):

    CA867131 BF056360 BM972053 BU543214 AI628681 BQ010275 AI992215 BM723282 
    AI470402 AW236830 BF593014 AI078587 CD359081 BU687703 BQ186459 BE206049 
    BF060680 AI247733 AA058418 AA812562 AA056560 AA514206 AI831729 BQ957188 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SOCS7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                  
    SP2:                    -     -                                       


    ECgene alternative splicing isoforms for SOCS7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOCS7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SOCS7 Expression
    About this image


    SOCS7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SOCS7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOCS7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514132

    UniProtKB/Swiss-Prot: SOCS7_HUMAN, O14512
    Tissue specificity: Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SOCS7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Socs71 , 5 suppressor of cytokine signaling 71, 5 91.12(n)1
    96.89(a)1
      11 (60.96 cM)5
    1921571  NM_138657.31  NP_619598.11 
     973625515 
    chicken
    (Gallus gallus)
    Aves SOCS71 suppressor of cytokine signaling 7 83.97(n)
    92.41(a)
      426232  XM_423895.4  XP_423895.4 
    lizard
    (Anolis carolinensis)
    Reptilia SOCS76
    suppressor of cytokine signaling 7
    97(a)
    1 ↔ 1
    6(73953671-73960250)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.25992 Transcribed sequence with moderate similarity to protein more 79.17(n)    AL848459.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005381861 suppressor of cytokine signaling 7-like 68.09(n)
    74.4(a)
      100538186  XM_005155763.1  XP_005155820.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Socs44A6
    Socs16D6
    Suppressor of Cytokine Signaling at 16D
    22(a)
    14(a)
    many ↔ many
    many ↔ many
    2R(4015136-4016981)
    X(17714797-17721553)


    ENSEMBL Gene Tree for SOCS7 (if available)
    TreeFam Gene Tree for SOCS7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOCS7 gene
    SOCS32  SOCS42  SOCS52  SOCS12  SOCS62  CISH2  SOCS22  
    1 SIMAP similar gene for SOCS7 using alignment to 3 protein entries:     SOCS7_HUMAN (see all proteins):
    SOCS2

    Find genes that share paralogs with SOCS7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOCS7 (see all 1151)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs414627471,2
    C,F--36506269(+) CAGGGG/CATGTG 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1478488451,2
    --36506352(+) AGCCAC/TGAACA 1 -- us2k10--------
    rs415193481,2
    C--36506544(+) TGGGCA/TCCCTG 1 -- us2k10--------
    rs1826385911,2
    --36506639(+) TTATCC/TCTGTG 1 -- us2k10--------
    rs1413602981,2
    --36506665(+) CGGGCA/GTGGGC 1 -- us2k10--------
    rs45817481,2
    C,F,A--36506666(-) cgcccA/GCGCCC 1 -- us2k19Minor allele frequency- G:0.34NA WA CSA 251
    rs42919581,2
    C,A--36506677(-) gtgagC/Acaccg 1 -- us2k12Minor allele frequency- A:0.11CSA NA 122
    rs415289441,2
    C,F--36506804(+) ACCTGG/AAGCGA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs413441451,2
    C,F--36506868(+) CGCCAT/CTGCAC 1 -- us2k12Minor allele frequency- C:0.25NA WA 4
    rs1877685841,2
    --36506896(+) AGAAAC/GATTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SOCS7 (36508007 - 36561846 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SOCS7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1311253CNV Deletion17803354
    esv1229884CNV Deletion17803354
    esv2715897CNV Deletion23290073
    nsv2041CNV Insertion18451855
    nsv469701CNV Loss16826518
    esv33106CNV Gain17666407
    dgv959e1CNV Complex17122850
    dgv957e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOCS7
    DNA2.0 Custom Variant and Variant Library Synthesis for SOCS7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608788    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SOCS7:
    Chronic fatigue syndrome

    Find genes that share disorders with SOCS7           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SOCS7 (6 documents)

    Export disorders for SOCS7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOCS7 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with SOCS7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PubMed id 9344857)1, 2, 3 Matuoka K.... Takenawa T. (Biochem. Biophys. Res. Commun. 1997)
    2. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PubMed id 15677474)1, 2, 9 Martens N....Gertler A. (J. Biol. Chem. 2005)
    3. Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines. (PubMed id 10969179)1, 2, 9 Dogusan Z.... Hooghe R. (J. Neuroimmunol. 2000)
    4. Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. (PubMed id 17803907)1, 2 Kremer B.E.... Macara I.G. (Cell 2007)
    5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)
    6. Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. (PubMed id 16127460)1, 2 Banks A.S....Rothman P.B. (J. Clin. Invest. 2005)
    7. The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. (PubMed id 15242778)1, 2 Martens N.... Hooghe-Peters E.L. (Exp. Cell Res. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
    10. socs7, a target gene of microRNA-145, regulates interferon-I^ induction through STAT3 nuclear translocation in bladder cancer cells. (PubMed id 23392170)1 Noguchi S....Akao Y. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30837 HGNC: 29846 AceView: SOCS7 Ensembl:ENSG00000174111 euGenes: HUgn30837
    ECgene: SOCS7 Kegg: 30837 H-InvDB: SOCS7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOCS7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SOCS7 gene:
    Search GeneIP for patents involving SOCS7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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