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Aliases for SOCS7 Gene

Aliases for SOCS7 Gene

  • Suppressor Of Cytokine Signaling 7 2 3 5
  • NCK-Associated Protein 4 2 3 4
  • Nck, Ash And Phospholipase C Gamma-Binding Protein 3 4
  • Nck, Ash And Phospholipase C Binding Protein 2 3
  • SOCS-7 3 4
  • NAP-4 3 4
  • NAP4 3 4
  • NCKAP4 3
  • SOCS6 4

External Ids for SOCS7 Gene

Previous GeneCards Identifiers for SOCS7 Gene

  • GC14P049305
  • GC14P053483
  • GC17P036869
  • GC17P033761
  • GC17P036508
  • GC17P032304

Summaries for SOCS7 Gene

GeneCards Summary for SOCS7 Gene

SOCS7 (Suppressor Of Cytokine Signaling 7) is a Protein Coding gene. Among its related pathways are Prolactin Signaling Pathway and Jak-STAT signaling pathway (KEGG). GO annotations related to this gene include SH3 domain binding and protein kinase inhibitor activity. An important paralog of this gene is SOCS6.

UniProtKB/Swiss-Prot for SOCS7 Gene

  • Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Gene Wiki entry for SOCS7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS7 Gene

Genomics for SOCS7 Gene

Regulatory Elements for SOCS7 Gene

Enhancers for SOCS7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F038323 1.3 FANTOM5 Ensembl ENCODE 12.6 -26.4 -26415 3.8 ATF1 CREB3L1 SIN3A ZNF2 ZNF48 ZNF121 CBX5 ZNF143 ZNF207 KLF13 SOCS7 MRPL45 TBC1D3 GPR179 GC17P038300 PIR49079
GH17F038322 0.4 ENCODE 12 -29.8 -29782 0.2 CTCF ZNF143 SMC3 MYC RAD21 GPR179 SOCS7 MRPL45 PIR49079 GC17P038300
GH17F038324 0.5 ENCODE 12 -30.0 -29992 0.2 CTCF MYC GPR179 SOCS7 PIR49079 GC17P038300
GH17F038320 0.7 ENCODE 12 -31.2 -31221 1.6 ZNF687 NRF1 SIN3A MNT DPF2 ZNF7 CTBP1 POLR2A MYC TCF7L2 GPR179 SOCS7 MRPL45 PIR49079 GC17P038300
GH17F038483 1 Ensembl ENCODE 11.4 +132.9 132850 2.1 HDGF TBP PKNOX1 KLF17 BMI1 RAD21 ZNF335 GLIS2 EGR1 SCRT2 ARHGAP23 SOCS7 ENSG00000276170 GC17P038481 PIR32449
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SOCS7 on UCSC Golden Path with GeneCards custom track

Promoters for SOCS7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001345361 176 2201 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9
ENSR00001806809 1776 201 MLLT1 KDM1A ZNF623

Genomic Location for SOCS7 Gene

Chromosome:
17
Start:
38,352,124 bp from pter
End:
38,405,593 bp from pter
Size:
53,470 bases
Orientation:
Plus strand

Genomic View for SOCS7 Gene

Genes around SOCS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOCS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOCS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS7 Gene

Proteins for SOCS7 Gene

  • Protein details for SOCS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14512-SOCS7_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 7
    Protein Accession:
    O14512
    Secondary Accessions:
    • A2VCU2
    • Q0IJ63

    Protein attributes for SOCS7 Gene

    Size:
    581 amino acids
    Molecular mass:
    62969 Da
    Quaternary structure:
    • Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6.
    SequenceCaution:
    • Sequence=AAI28608.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence.; Evidence={ECO:0000305}; Sequence=BAA22432.1; Type=Erroneous termination; Positions=582; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for SOCS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOCS7 Gene

Post-translational modifications for SOCS7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOCS7 Gene

Antibody Products

  • R&D Systems Antibodies for SOCS7 (SOCS-7/Nck/NAP4)
  • Abcam antibodies for SOCS7
  • Santa Cruz Biotechnology (SCBT) Antibodies for SOCS7

No data available for DME Specific Peptides for SOCS7 Gene

Domains & Families for SOCS7 Gene

Protein Domains for SOCS7 Gene

Suggested Antigen Peptide Sequences for SOCS7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14512

UniProtKB/Swiss-Prot:

SOCS7_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.
  • Contains 1 SH2 domain.
  • Contains 1 SOCS box domain.
genes like me logo Genes that share domains with SOCS7: view

Function for SOCS7 Gene

Molecular function for SOCS7 Gene

UniProtKB/Swiss-Prot Function:
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
UniProtKB/Swiss-Prot Induction:
By IL6/interleukin-6, prolactin and growth hormone.

Gene Ontology (GO) - Molecular Function for SOCS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005515 protein binding IPI 20598684
GO:0017124 SH3 domain binding NAS 9344857
genes like me logo Genes that share ontologies with SOCS7: view
genes like me logo Genes that share phenotypes with SOCS7: view

Animal Models for SOCS7 Gene

MGI Knock Outs for SOCS7:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS7 Gene

Localization for SOCS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOCS7 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOCS7 Gene COMPARTMENTS Subcellular localization image for SOCS7 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SOCS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SOCS7: view

Pathways & Interactions for SOCS7 Gene

genes like me logo Genes that share pathways with SOCS7: view

Pathways by source for SOCS7 Gene

1 BioSystems pathway for SOCS7 Gene
1 R&D Systems pathway for SOCS7 Gene

UniProtKB/Swiss-Prot O14512-SOCS7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SOCS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0008150 biological_process ND --
GO:0008286 insulin receptor signaling pathway IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with SOCS7: view

No data available for SIGNOR curated interactions for SOCS7 Gene

Transcripts for SOCS7 Gene

Unigene Clusters for SOCS7 Gene

Suppressor of cytokine signaling 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS7 Gene

No ASD Table

Relevant External Links for SOCS7 Gene

GeneLoc Exon Structure for
SOCS7
ECgene alternative splicing isoforms for
SOCS7

Expression for SOCS7 Gene

mRNA expression in normal human tissues for SOCS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOCS7 Gene

This gene is overexpressed in Testis (x17.9) and Brain - Cerebellar Hemisphere (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of SOCS7 Gene:

SOCS7

SOURCE GeneReport for Unigene cluster for SOCS7 Gene:

Hs.514132

mRNA Expression by UniProt/SwissProt for SOCS7 Gene:

O14512-SOCS7_HUMAN
Tissue specificity: Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.
genes like me logo Genes that share expression patterns with SOCS7: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SOCS7 Gene

Orthologs for SOCS7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SOCS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOCS7 34
  • 99.91 (n)
cow
(Bos Taurus)
Mammalia SOCS7 34
  • 94.57 (n)
dog
(Canis familiaris)
Mammalia SOCS7 34
  • 94 (n)
rat
(Rattus norvegicus)
Mammalia Socs7 34
  • 91.58 (n)
mouse
(Mus musculus)
Mammalia Socs7 34 16
  • 91.12 (n)
chicken
(Gallus gallus)
Aves SOCS7 34
  • 83.97 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia socs7 34
  • 74 (n)
Str.2599 34
zebrafish
(Danio rerio)
Actinopterygii LOC100538186 34
  • 68.09 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10743 34
Species where no ortholog for SOCS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOCS7 Gene

ENSEMBL:
Gene Tree for SOCS7 (if available)
TreeFam:
Gene Tree for SOCS7 (if available)

Paralogs for SOCS7 Gene

Paralogs for SOCS7 Gene

(1) SIMAP similar genes for SOCS7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SOCS7: view

Variants for SOCS7 Gene

Sequence variations from dbSNP and Humsavar for SOCS7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1045638 -- 38,401,285(+) TATTA(C/T)CAACT nc-transcript-variant, utr-variant-3-prime
rs111228668 -- 38,401,455(+) CTTTC(-/T)TTTTT nc-transcript-variant, utr-variant-3-prime
rs111278870 -- 38,404,859(+) CTTTG(A/G)GTAGC nc-transcript-variant, utr-variant-3-prime
rs111419149 -- 38,361,574(+) ATGCT(G/T)TATTA intron-variant
rs111451958 -- 38,395,829(+) ATATC(C/T)GTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SOCS7 Gene

Variant ID Type Subtype PubMed ID
esv2758688 CNV gain+loss 17122850
esv33106 CNV gain 17666407
nsv1129385 OTHER inversion 24896259
nsv1146669 OTHER inversion 26484159
nsv2041 CNV insertion 18451855
nsv428341 CNV gain+loss 18775914
nsv469701 CNV loss 16826518

Variation tolerance for SOCS7 Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOCS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOCS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS7 Gene

Disorders for SOCS7 Gene

Relevant External Links for SOCS7

Human Genome Epidemiology (HuGE) Navigator
SOCS7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOCS7

No disorders were found for SOCS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOCS7 Gene

Publications for SOCS7 Gene

  1. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PMID: 15677474) Martens N. … Gertler A. (J. Biol. Chem. 2005) 3 4 22 64
  2. Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines. (PMID: 10969179) Dogusan Z. … Hooghe R. (J. Neuroimmunol. 2000) 3 4 22 64
  3. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PMID: 9344857) Matuoka K. … Takenawa T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 64
  4. Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. (PMID: 17803907) Kremer B.E. … Macara I.G. (Cell 2007) 3 4 64
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64

Products for SOCS7 Gene

Sources for SOCS7 Gene

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