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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOCS7 Gene

protein-coding   GIFtS: 56
GCID: GC17P036508

Suppressor Of Cytokine Signaling 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppressor Of Cytokine Signaling 71 2     Nck1
Nck-Associated Protein 41 2 3     Ash And Phospholipase C Binding Protein1
Nck, Ash And Phospholipase C Gamma-Binding Protein2 3     NCKAP42
NAP-42 3     Nck, Ash And Phospholipase C Binding Protein2
NAP42 3     SOCS63
SOCS-72 3     

External Ids:    HGNC: 298461   Entrez Gene: 308372   Ensembl: ENSG000001741117   OMIM: 6087885   UniProtKB: O145123   

Export aliases for SOCS7 gene to outside databases

Previous GC identifers: GC14P049305 GC14P053483 GC17P036869 GC17P033761 GC17P032304


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SOCS7 Gene: 
SOCS7 (suppressor of cytokine signaling 7) is a protein-coding gene. Diseases associated with SOCS7 include chronic fatigue syndrome, and hepatitis c, and among its related super-pathways are Development Prolactin receptor signaling. GO annotations related to this gene include protein binding and SH3 domain binding. An important paralog of this gene is SOCS3.

UniProtKB/Swiss-Prot: SOCS7_HUMAN, O14512
Function: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in
insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation.
Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation,
sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of
a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal
degradation of target proteins (By similarity)

Gene Wiki entry for SOCS7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOCS7 gene promoter:
         MAZR   ATF-2   GATA-1   Egr-2   POU2F1   POU2F1a   STAT3   c-Myb   SEF-1 (1)   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOCS7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOCS7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOCS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q21.1

SOCS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P036508:  view genomic region     (about GC identifiers)

Start:
36,508,007 bp from pter      End:
36,561,846 bp from pter
Size:
53,840 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003315948 135,391-189,231     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SOCS7_HUMAN, O14512 (See protein sequence)
Recommended Name: Suppressor of cytokine signaling 7  
Size: 581 amino acids; 62969 Da
Subunit: Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts, via the third proline-rich
region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1,
SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus
after UV irradiation. Cytoplasmic location depends upon SEPT7 presence
Sequence caution: Sequence=AAI28608.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus
may be contaminated with vector sequence; Sequence=BAA22432.1; Type=Erroneous termination; Positions=582;
Note=Translated as stop;
Secondary accessions: A2VCU2 Q0IJ63
Alternative splicing: 2 isoforms:  O14512-1   O14512-2   

Explore the universe of human proteins at neXtProt for SOCS7: NX_O14512

Explore proteomics data for SOCS7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14512

  • SOCS7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SOCS7 Protein Expression
    REFSEQ proteins: NP_055413.1  
    ENSEMBL proteins: 
     ENSP00000330659   ENSP00000464034   ENSP00000462569  

    Human Recombinant Protein Products for SOCS7: 
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    Cloud-Clone Corp. Proteins for SOCS7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IEA--

    SOCS7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SOCS: Suppressors of cytokine signaling
    SH2D: SH2 domain containing

    2 InterPro protein domains:
     IPR001496 SOCS_C
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry O14512

    ProtoNet protein and cluster: O14512

    1 Blocks protein domain: IPB001496 SOCS protein

    UniProtKB/Swiss-Prot: SOCS7_HUMAN, O14512
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal
    degradation
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SOCS box domain


    SOCS7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOCS7_HUMAN, O14512
    Function: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in
    insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation.
    Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation,
    sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of
    a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal
    degradation of target proteins (By similarity)
    Induction: By IL6/interleukin-6, prolactin and growth hormone

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17803907
    GO:0017124SH3 domain binding NAS9344857
         
    SOCS7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SOCS7:
     Decreased viability with pacli 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Socs7):
     behavior/neurological  cardiovascular system  craniofacial  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  mortality/aging  nervous system  skeleton 

    SOCS7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SOCS7: Socs7tm1Wsa Socs7tm1Pbro

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SOCS7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SOCS7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOCS7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOCS7 

    miRNA
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    hsa-miR-140-5p hsa-miR-106a hsa-miR-199a-3p hsa-miR-938 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSOCS7 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SOCS7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development Prolactin receptor signaling
    Leptin signaling pathway0.35
    Prolactin signaling pathway0.33
    2Jak-STAT signaling pathway
    Jak-STAT signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SOCS7
        Leptin signaling pathway


    2         Kegg Pathways  (Kegg details for SOCS7):
        Jak-STAT signaling pathway
    Prolactin signaling pathway

    UniProtKB/Swiss-Prot: SOCS7_HUMAN, O14512
    Pathway: Protein modification; protein ubiquitination


    SOCS7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOCS7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for SOCS7 (O145121, 2, 3 ENSP000003306594) via UniProtKB, MINT, STRING, and/or I2D (see all 61)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SORBS3O605042, 3, ENSP000002401234MINT-56622 MINT-56620 MINT-56615 I2D: score=2 STRING: ENSP00000240123
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908139 MINT-7908538 I2D: score=1 STRING: ENSP00000365312
    SEPT6Q141411, 3, ENSP000003415244EBI-1539617,EBI-745901 I2D: score=2 STRING: ENSP00000341524
    IRS2Q9Y4H23, ENSP000003650164I2D: score=1 STRING: ENSP00000365016
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0008286insulin receptor signaling pathway IEA--
    GO:0009968negative regulation of signal transduction IEA--
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    SOCS7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOCS7

    Search CenterWatch for drugs/clinical trials and news about SOCS7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SOCS7 gene: 
    NM_014598.2  

    Unigene Cluster for SOCS7:

    Suppressor of cytokine signaling 7
    Hs.514132  [show with all ESTs]
    Unigene Representative Sequence: NM_014598
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331159 ENST00000577233(uc002hqa.3 uc010cvl.3) ENST00000584132(uc002hqb.3)
    ENST00000580660
    miRNA
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    8/152 QIAGEN miScript miRNA Assays for microRNAs that regulate SOCS7 (see all 152):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-199a-3p hsa-miR-938 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSOCS7 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB005216.1 AK094338.1 BC121030.1 BC121031.1 BC128607.1 

    4 DOTS entries:

    DT.413889  DT.95264284  DT.92418134  DT.75102249 

    24/186 AceView cDNA sequences (see all 186):

    BQ957188 AI675289 BU687703 AI831729 AW236830 AA056560 AA514206 BQ186459 
    AA058418 AI247733 BE206049 AI480099 CA867131 CD359081 BE858647 BF593014 
    AI057292 AW140030 AW002013 BQ920093 AL135718 BQ010275 BF060680 BF056360 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SOCS7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                  
    SP2:                    -     -                                       


    ECgene alternative splicing isoforms for SOCS7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOCS7 expression in normal human tissues (normalized intensities)      SOCS7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SOCS7 Expression
    About this image


    SOCS7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             sperm   

    See SOCS7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SOCS7

    SOURCE GeneReport for Unigene cluster: Hs.514132

    UniProtKB/Swiss-Prot: SOCS7_HUMAN, O14512
    Tissue specificity: Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SOCS7 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Socs71 , 5 suppressor of cytokine signaling 71, 5 91.75(n)1
    97.92(a)1
      11 (60.96 cM)5
    1921571  NM_138657.31  NP_619598.11 
     973625515 
    chicken
    (Gallus gallus)
    Aves SOCS71 suppressor of cytokine signaling 7 84.55(n)
    93.13(a)
      426232  XM_423895.3  XP_423895.3 
    lizard
    (Anolis carolinensis)
    Reptilia SOCS76
    Uncharacterized protein
    97(a)
    1 ↔ 1
    6(73953671-73960250)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.25992 Transcribed sequence with moderate similarity to protein more 79.17(n)    AL848459.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005381861 uncharacterized LOC100538186 62.43(n)
    64.06(a)
      100538186  XM_003199461.1  XP_003199509.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Socs16D6
    Suppressor of Cytokine Signaling at 16D
    11(a)
    1 ↔ 1
    X(17714797-17721553)


    ENSEMBL Gene Tree for SOCS7 (if available)
    TreeFam Gene Tree for SOCS7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOCS7 gene
    SOCS32  SOCS42  SOCS52  SOCS12  SOCS62  CISH2  SOCS22  
    1 SIMAP similar gene for SOCS7 using alignment to 3 protein entries:     SOCS7_HUMAN (see all proteins):
    SOCS2

    SOCS7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1151 SNPs in SOCS7 are shown (see all 1151)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs414627471,2
    C,F--36506269(+) CAGGGG/CATGTG 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1478488451,2
    --36506352(+) AGCCAC/TGAACA 1 -- us2k10--------
    rs415193481,2
    C--36506544(+) TGGGCA/TCCCTG 1 -- us2k10--------
    rs1826385911,2
    --36506639(+) TTATCC/TCTGTG 1 -- us2k10--------
    rs1413602981,2
    --36506665(+) CGGGCA/GTGGGC 1 -- us2k10--------
    rs45817481,2
    C,F,A--36506666(-) cgcccA/GCGCCC 1 -- us2k19Minor allele frequency- G:0.34NA WA CSA 251
    rs42919581,2
    C,A--36506677(-) gtgagC/Acaccg 1 -- us2k12Minor allele frequency- A:0.11CSA NA 122
    rs415289441,2
    C,F--36506804(+) ACCTGG/AAGCGA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs413441451,2
    C,F--36506868(+) CGCCAT/CTGCAC 1 -- us2k12Minor allele frequency- C:0.25NA WA 4
    rs1877685841,2
    --36506896(+) AGAAAC/GATTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SOCS7 (36508007 - 36561846 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SOCS7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1311253CNV Deletion17803354
    esv1229884CNV Deletion17803354
    esv2715897CNV Deletion23290073
    nsv2041CNV Insertion18451855
    nsv469701CNV Loss16826518
    esv33106CNV Gain17666407
    dgv959e1CNV Complex17122850
    dgv957e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608788    OMIM disorders: --

    6 diseases for SOCS7:    About MalaCards
    chronic fatigue syndrome    hepatitis c    hepatitis    breast cancer
    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SOCS7:
    Chronic fatigue syndrome

    SOCS7 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SOCS7 (6 documents)

    Export disorders for SOCS7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOCS7 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with SOCS7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PubMed id 9344857)1, 2, 3 Matuoka K.... Takenawa T. (1997)
    2. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PubMed id 15677474)1, 2, 9 Martens N....Gertler A. (2005)
    3. Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines. (PubMed id 10969179)1, 2, 9 Dogusan Z.... Hooghe R. (2000)
    4. Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. (PubMed id 17803907)1, 2 Kremer B.E.... Macara I.G. (2007)
    5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
    6. Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. (PubMed id 16127460)1, 2 Banks A.S....Rothman P.B. (2005)
    7. The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. (PubMed id 15242778)1, 2 Martens N.... Hooghe-Peters E.L. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (2002)
    10. socs7, a target gene of microRNA-145, regulates interf eron-b induction through STAT3 nuclear translocation in bladder cancer cells. (PubMed id 23392170)1 Noguchi S....Akao Y. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 30837 HGNC: 29846 AceView: SOCS7 Ensembl:ENSG00000174111 euGenes: HUgn30837
    ECgene: SOCS7 Kegg: 30837 H-InvDB: SOCS7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOCS7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SOCS7 gene:
    Search GeneIP for patents involving SOCS7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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