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Aliases for SOCS6 Gene

Aliases for SOCS6 Gene

  • Suppressor Of Cytokine Signaling 6 2 3 5
  • Suppressor Of Cytokine Signaling 4 2 3 4
  • Cytokine-Inducible SH2 Protein 4 3 4
  • SOCS-4 3 4
  • SOCS-6 3 4
  • SOCS4 3 4
  • CIS-4 3 4
  • CIS4 3 4
  • STAT Induced STAT Inhibitor-4 3
  • HSPC060 3
  • STATI4 3
  • STAI4 3
  • SSI4 3

External Ids for SOCS6 Gene

Previous HGNC Symbols for SOCS6 Gene

  • SOCS4

Previous GeneCards Identifiers for SOCS6 Gene

  • GC18P066106
  • GC18P066107
  • GC18P067956
  • GC18P064675

Summaries for SOCS6 Gene

Entrez Gene Summary for SOCS6 Gene

  • The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOCS6 Gene

SOCS6 (Suppressor Of Cytokine Signaling 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Type II diabetes mellitus. GO annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS7.

UniProtKB/Swiss-Prot for SOCS6 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

Gene Wiki entry for SOCS6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS6 Gene

Genomics for SOCS6 Gene

Regulatory Elements for SOCS6 Gene

Promoters for SOCS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SOCS6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOCS6 Gene

Chromosome:
18
Start:
70,288,901 bp from pter
End:
70,330,200 bp from pter
Size:
41,300 bases
Orientation:
Plus strand

Genomic View for SOCS6 Gene

Genes around SOCS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOCS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOCS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS6 Gene

Proteins for SOCS6 Gene

  • Protein details for SOCS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14544-SOCS6_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 6
    Protein Accession:
    O14544
    Secondary Accessions:
    • Q8WUM3

    Protein attributes for SOCS6 Gene

    Size:
    535 amino acids
    Molecular mass:
    59528 Da
    Quaternary structure:
    • Interacts with RBCK1. Interacts with phosphorylated IRS4 (By similarity). Interacts with PIM3 (By similarity). Interacts with KIT (phosphorylated).

    Three dimensional structures from OCA and Proteopedia for SOCS6 Gene

neXtProt entry for SOCS6 Gene

Proteomics data for SOCS6 Gene at MOPED

Post-translational modifications for SOCS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOCS6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SOCS6 Gene

Domains & Families for SOCS6 Gene

Protein Domains for SOCS6 Gene

Suggested Antigen Peptide Sequences for SOCS6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14544

UniProtKB/Swiss-Prot:

SOCS6_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 SH2 domain.
  • Contains 1 SOCS box domain.
genes like me logo Genes that share domains with SOCS6: view

Function for SOCS6 Gene

Molecular function for SOCS6 Gene

UniProtKB/Swiss-Prot Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

Gene Ontology (GO) - Molecular Function for SOCS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with SOCS6: view
genes like me logo Genes that share phenotypes with SOCS6: view

Animal Models for SOCS6 Gene

MGI Knock Outs for SOCS6:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS6 Gene

Localization for SOCS6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOCS6 Gene COMPARTMENTS Subcellular localization image for SOCS6 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SOCS6 Gene

Pathways & Interactions for SOCS6 Gene

genes like me logo Genes that share pathways with SOCS6: view

Pathways by source for SOCS6 Gene

UniProtKB/Swiss-Prot O14544-SOCS6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SOCS6 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for SOCS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0006952 defense response TAS 9344848
GO:0007259 JAK-STAT cascade TAS 9344848
GO:0010498 proteasomal protein catabolic process IMP 20007709
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with SOCS6: view

Drugs & Compounds for SOCS6 Gene

No Compound Related Data Available

Transcripts for SOCS6 Gene

mRNA/cDNA for SOCS6 Gene

Unigene Clusters for SOCS6 Gene

Suppressor of cytokine signaling 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS6 Gene

No ASD Table

Relevant External Links for SOCS6 Gene

GeneLoc Exon Structure for
SOCS6
ECgene alternative splicing isoforms for
SOCS6

Expression for SOCS6 Gene

mRNA expression in normal human tissues for SOCS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOCS6 Gene



SOURCE GeneReport for Unigene cluster for SOCS6 Gene Hs.44439

genes like me logo Genes that share expression patterns with SOCS6: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SOCS6 Gene

Orthologs for SOCS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOCS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOCS6 36
  • 100 (a)
OneToOne
SOCS6 35
  • 99.69 (n)
  • 99.63 (a)
cow
(Bos Taurus)
Mammalia SOCS6 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
LOC100856303 35
  • 89.6 (n)
  • 94.58 (a)
mouse
(Mus musculus)
Mammalia Socs6 36
  • 85 (a)
OneToOne
Socs6 16
Socs6 35
  • 80.38 (n)
  • 85.66 (a)
oppossum
(Monodelphis domestica)
Mammalia SOCS6 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Socs6 35
  • 80.57 (n)
  • 84.91 (a)
chicken
(Gallus gallus)
Aves SOCS6 35
  • 83.15 (n)
  • 90.45 (a)
gga-mir-6584 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOCS6 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3745 35
tropical clawed frog
(Silurana tropicalis)
Amphibia socs6 35
  • 77.86 (n)
  • 83.11 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7466 35
zebrafish
(Danio rerio)
Actinopterygii BX640518.1 36
  • 72 (a)
OneToMany
socs6b 36
  • 71 (a)
OneToMany
LOC558703 35
  • 68.47 (n)
  • 72.78 (a)
wufb77f06 35
fruit fly
(Drosophila melanogaster)
Insecta Socs16D 36
  • 13 (a)
ManyToMany
Socs44A 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.625 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8442 36
  • 37 (a)
OneToOne
Species with no ortholog for SOCS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOCS6 Gene

ENSEMBL:
Gene Tree for SOCS6 (if available)
TreeFam:
Gene Tree for SOCS6 (if available)

Paralogs for SOCS6 Gene

Paralogs for SOCS6 Gene

(1) SIMAP similar genes for SOCS6 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SOCS6 Gene

genes like me logo Genes that share paralogs with SOCS6: view

Variants for SOCS6 Gene

Sequence variations from dbSNP and Humsavar for SOCS6 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs967607 -- 70,302,337(-) cactc(C/T)catta intron-variant
rs1047668 -- 70,326,854(+) CATAT(C/T)TTTTA utr-variant-3-prime
rs713131 -- 70,293,330(-) GGCCA(G/T)GTAAT intron-variant
rs1660106 -- 70,290,202(+) CCAGA(C/G)ACATT intron-variant
rs1660107 -- 70,290,217(+) ATTTA(C/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SOCS6 Gene

Variant ID Type Subtype PubMed ID
esv32736 CNV Gain+Loss 17666407
esv34014 CNV Loss 18971310

Variation tolerance for SOCS6 Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOCS6 Gene

HapMap Linkage Disequilibrium report
SOCS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS6 Gene

Disorders for SOCS6 Gene

Relevant External Links for SOCS6

Genetic Association Database (GAD)
SOCS6
Human Genome Epidemiology (HuGE) Navigator
SOCS6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOCS6

No disorders were found for SOCS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOCS6 Gene

Publications for SOCS6 Gene

  1. Cloning and characterization of novel CIS family genes. (PMID: 9344848) Masuhara M. … Yoshimura A. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SOCS6 Gene

Sources for SOCS6 Gene

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