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SOCS6 Gene

protein-coding   GIFtS: 58
GCID: GC18P067956

Suppressor Of Cytokine Signaling 6

(Previous name: suppressor of cytokine signaling 4)
(Previous symbol: SOCS4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Cytokine Signaling 61 2     SOCS-62 3
SOCS41 2 3 5     SSI42 5
Suppressor Of Cytokine Signaling 41 2 3     HSPC0602
CIS42 3 5     STAI42
Cytokine-Inducible SH2 Protein 42 3     STATI42
CIS-42 3     STAT Induced STAT Inhibitor-42
SOCS-42 3     STAT45

External Ids:    HGNC: 168331   Entrez Gene: 93062   Ensembl: ENSG000001706777   OMIM: 6051185   UniProtKB: O145443   

Export aliases for SOCS6 gene to outside databases

Previous GC identifers: GC18P066106 GC18P066107 GC18P064675


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOCS6 Gene:
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the
cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT
inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of
cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high
expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and
erythroleukemia (HEL) cell lines. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOCS6 Gene:
SOCS6 (suppressor of cytokine signaling 6) is a protein-coding gene. An important paralog of this gene is SOCS3.

UniProtKB/Swiss-Prot: SOCS6_HUMAN, O14544
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated
receptor

Gene Wiki entry for SOCS6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOCS6 gene promoter:
         C/EBPbeta   POU6F1 (c2)   MIF-1   CUTL1   POU3F2   Evi-1   C/EBPalpha   IRF-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOCS6 promoter sequence
   Search Chromatin IP Primers for SOCS6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOCS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.2   Ensembl cytogenetic band:  18q22.2   HGNC cytogenetic band: 18q22

SOCS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS6 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P067956:  view genomic region     (about GC identifiers)

Start:
67,956,137 bp from pter      End:
67,997,436 bp from pter
Size:
41,300 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SOCS6_HUMAN, O14544 (See protein sequence)
Recommended Name: Suppressor of cytokine signaling 6  
Size: 535 amino acids; 59528 Da
Subunit: Interacts with RBCK1. Interacts with phosphorylated IRS4 (By similarity). Interacts with PIM3 (By
similarity). Interacts with KIT (phosphorylated)
1 PDB 3D structure from and Proteopedia for SOCS6:
2VIF (3D)    
Secondary accessions: Q8WUM3

Explore the universe of human proteins at neXtProt for SOCS6: NX_O14544

Explore proteomics data for SOCS6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOCS6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004223.2  
    ENSEMBL proteins: 
     ENSP00000381034   ENSP00000463064   ENSP00000463395  
    Reactome Protein details: O14544

    SOCS6 Human Recombinant Protein Products:

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    Novus Biologicals SOCS6 Protein
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    Cloud-Clone Corp. Proteins for SOCS6

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SOCS: Suppressors of cytokine signaling
    SH2D: SH2 domain containing

    4 InterPro protein domains:
     IPR001496 SOCS_C
     IPR000980 SH2
     IPR028413 SOCS
     IPR028421 SOCS6

    Graphical View of Domain Structure for InterPro Entry O14544

    ProtoNet protein and cluster: O14544

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001496 SOCS protein


    UniProtKB/Swiss-Prot: SOCS6_HUMAN, O14544
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes (By similarity)
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SOCS box domain


    Find genes that share domains with SOCS6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOCS6_HUMAN, O14544
    Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
    transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated
    receptor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SOCS6           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Socs6):
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with SOCS6           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOCS6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOCS6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOCS6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOCS6

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for SOCS6 (see all 165):
    ACCSL,  ACSM2A,  ADIG,  ADORA1,  ADRB3,  ALB,  ALG1,  APBB2,  ARID3B,  ASPHD2

    miRNA
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    miRTarBase miRNAs that target SOCS6:
    hsa-mir-23b-3p (MIRT046359), hsa-mir-203a (MIRT006856)

    Block miRNA regulation of human, mouse, rat SOCS6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOCS6 (see all 120):
    hsa-miR-300 hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidSOCS6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOCS6
    Predesigned siRNA for gene silencing in human, mouse, rat SOCS6

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SOCS6

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOCS6 (NM_004232)
    Sino Biological Human cDNA Clone for SOCS6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS6
    Addgene plasmids for SOCS6 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SOCS6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    mitochondrion2
    nucleus2
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA--
    GO:0005737cytoplasm TAS9344848

    Find genes that share ontologies with SOCS6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOCS6 About    
    See pathways by source

    SuperPathContained pathways About
    1PI-3K cascade
    Signaling by SCF-KIT0.72
    Regulation of KIT signaling0.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Kit Receptor Signaling Pathway
    Kit Receptor Signaling Pathway0.37
    4IL-9 Signaling Pathways
    IL-9 Pathway0.36
    5Prolactin Signaling Pathway
    Prolactin signaling pathway0.33


    Find genes that share SuperPaths with SOCS6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SOCS6
        IL-9 Pathway

    1 BioSystems Pathway for SOCS6
        Kit Receptor Signaling Pathway


    1 Reactome Pathway for SOCS6
        Regulation of KIT signaling


    1 Kegg Pathway  (Kegg details for SOCS6):
        Prolactin signaling pathway

    UniProtKB/Swiss-Prot: SOCS6_HUMAN, O14544
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including SOCS6: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SOCS6

    Selected Interacting proteins for SOCS6 (O145443) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713I2D: score=3 
    BMPR1BO002383I2D: score=3 
    PIK3R1P279863I2D: score=3 
    PIK3R2O004593I2D: score=3 
    TGFBR1P368973I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS9344848
    GO:0007259JAK-STAT cascade TAS9344848
    GO:0009968negative regulation of signal transduction IEA--
    GO:0010498proteasomal protein catabolic process IMP--
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with SOCS6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOCS6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOCS6 gene: 
    NM_004232.3  

    Unigene Cluster for SOCS6:

    Suppressor of cytokine signaling 6
    Hs.44439  [show with all ESTs]
    Unigene Representative Sequence: NM_004232
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397942(uc002lkr.1 uc010dqq.2) ENST00000578377 ENST00000582322

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SOCS6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOCS6 (see all 120):
    hsa-miR-300 hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidSOCS6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SOCS6
    Predesigned siRNA for gene silencing in human, mouse, rat SOCS6
    Clone
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    OriGene clones in human, mouse for SOCS6 (see all 7)
    OriGene ORF clones in mouse, rat for SOCS6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOCS6 (NM_004232)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS6
    Addgene plasmids for SOCS6 
    Primer
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    OriGene qPCR primer pairs and template standards for SOCS6
    OriGene qSTAR qPCR primer pairs in human, mouse for SOCS6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOCS6
      QuantiTect SYBR Green Assays in human, mouse, rat SOCS6
      QuantiFast Probe-based Assays in human, mouse, rat SOCS6

    Additional mRNA sequence: 

    AB006968.1 AK024356.1 BC020082.1 

    6 DOTS entries:

    DT.95264618  DT.100890782  DT.100679557  DT.100771452  DT.40307376  DT.444895 

    Selected AceView cDNA sequences (see all 109):

    BX957035 CA443150 NM_004232 CB137375 BQ188776 CB164425 BM722265 N46335 
    Z40663 CF131623 AI091113 BF594130 CR601456 CA311534 BQ230047 AI382187 
    BQ022878 N48841 AA243026 BU184436 BF477435 BQ027376 BU166877 BU740117 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOCS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACCTATG
    SOCS6 Expression
    About this image


    SOCS6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Medulla Oblongata
    SOCS6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOCS6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.44439
        Pathway & Disease-focused RT2 Profiler PCR Array including SOCS6: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for SOCS6
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    QuantiTect SYBR Green Assays in human, mouse, rat SOCS6
    QuantiFast Probe-based Assays in human, mouse, rat SOCS6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SOCS6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Socs61 , 5 suppressor of cytokine signaling 61, 5 80.38(n)1
    85.66(a)1
      18 (58.66 cM)5
    546071  NM_018821.41  NP_061291.21 
     886652245 
    chicken
    (Gallus gallus)
    Aves SOCS61 suppressor of cytokine signaling 6 83.15(n)
    90.45(a)
      421020  NM_001127312.1  NP_001120784.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOCS66
    suppressor of cytokine signaling 6
    89(a)
    1 ↔ 1
    4(47148308-47149909)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37452 Xenopus laevis transcribed sequence with strong similarity more 81.45(n)    BQ386670.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb77f062 wufb77f06 76.62(n)   322950  BC054619.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Socs44A6
    Socs16D6
    Suppressor of Cytokine Signaling at 16D
    25(a)
    13(a)
    many ↔ many
    many ↔ many
    2R(4015136-4016981)
    X(17714797-17721553)


    ENSEMBL Gene Tree for SOCS6 (if available)
    TreeFam Gene Tree for SOCS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOCS6 gene
    SOCS32  SOCS42  SOCS52  SOCS72  SOCS12  CISH2  SOCS22  
    1 SIMAP similar gene for SOCS6 using alignment to 2 protein entries:     SOCS6_HUMAN (see all proteins):
    SOCS2

    Find genes that share paralogs with SOCS6           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SOCS6
    PGOHUM00000242387 PGOHUM00000250052


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOCS6 (see all 1040)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470428701,2
    --67954244(+) TCGAGC/TCCCCT 1 -- us2k10--------
    rs344903151,2
    C,F--67954345(+) CTGCAC/GCAGCT 1 -- us2k16Minor allele frequency- G:0.07NA WA EA 248
    rs1383161941,2
    --67954444(+) GCTGCA/GTGAAA 1 -- us2k10--------
    rs1495794901,2
    --67954461(+) CTAACC/TCCCTG 1 -- us2k10--------
    rs20623441,2
    C,A,H--67954520(-) CTCGGG/AGTTCC 1 -- us2k116Minor allele frequency- A:0.01NS EA NA WA CSA 792
    rs72389721,2
    C,F--67954597(+) cccagG/Tctgga 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs72399641,2
    C,F--67954663(+) tctccC/Tgcctc 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1839833771,2
    --67954754(+) ACTGTG/TTTGGC 1 -- us2k10--------
    rs1415481271,2
    --67954801(+) CGCCTC/TGGCCT 1 -- us2k10--------
    rs414254511,2
    C,F--67954810(+) CTCCCA/GAAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SOCS6 (67956137 - 67997436 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SOCS6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34014CNV Loss18971310
    esv32736CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605118    OMIM disorders: --


    Find genes that share disorders with SOCS6           About GenesLikeMe

    1 Novoseek inferred disease relationship for SOCS6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 12689942 (1), 12928496 (1)

    Genetic Association Database (GAD): SOCS6
    Human Genome Epidemiology (HuGE) Navigator: SOCS6 (6 documents)

    Export disorders for SOCS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOCS6 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with SOCS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of novel CIS family genes. (PubMed id 9344848)1, 2, 3 Masuhara M.... Yoshimura A. (Biochem. Biophys. Res. Commun. 1997)
    2. Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase. (PubMed id 21030588)1, 2 Zadjali F.... Flores-Morales A. (J. Biol. Chem. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. (PubMed id 18204098)1, 4 Hom G....Behrens T.W. (N. Engl. J. Med. 2008)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    7. Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation. (PubMed id 22955947)1 Lin H.Y....Chen J.Y. (Cell Death Differ. 2013)
    8. Reduced expression of SOCS2 and SOCS6 in hepatocellular carcinoma correlates with aggressive tumor progression and poor prognosis. (PubMed id 23475171)1 Qiu X....Zhang Y. (Mol. Cell. Biochem. 2013)
    9. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    10. SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues. (PubMed id 22081311)1 Yoon S....Nam S.W. (Tumour Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9306 HGNC: 16833 AceView: SOCS6 Ensembl:ENSG00000170677 euGenes: HUgn9306
    ECgene: SOCS6 Kegg: 9306 H-InvDB: SOCS6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOCS6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOCS6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOCS6 gene:
    Search GeneIP for patents involving SOCS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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