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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOCS6 Gene

protein-coding   GIFtS: 57
GCID: GC18P067956

suppressor of cytokine signaling 6

(Previous name: suppressor of cytokine signaling 4 )
(Previous symbol: SOCS4)
 Explore 14 diseases affiliated with
SOCS6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SOCS6    

Aliases
for SOCS6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Suppressor Of Cytokine Signaling 61 2     Cytokine-Inducible SH2 Protein 42 3
CIS41 2 3 5     CIS-42 3
SOCS41 2 3 5     SOCS-42 3
Suppressor Of Cytokine Signaling 41 2 3     SOCS-62 3
SSI41 2 5     Cish41
HSPC0601 2     STAT Induced STAT Inhibitor-42
STAI41 2     STAT45
STATI41 2     

External Ids:    HGNC: 168331   Entrez Gene: 93062   Ensembl: ENSG000001706777   OMIM: 6051185   UniProtKB: O145443   

Export aliases for SOCS6 gene to outside databases

Previous GC identifers: GC18P066106 GC18P066107 GC18P064675


Summaries
for SOCS6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SOCS6:
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the
cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT
inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine
signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression
level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell
lines. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SOCS6_HUMAN, O14544
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor

Gene Wiki entry for SOCS6


Genomic Views
for SOCS6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOCS6 gene promoter:
         C/EBPbeta   POU6F1 (c2)   MIF-1   CUTL1   POU3F2   Evi-1   C/EBPalpha   IRF-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SOCS6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOCS6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOCS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.2   Ensembl cytogenetic band:  18q22.2   HGNC cytogenetic band: 18q22

SOCS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS6 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P067956:  view genomic region     (about GC identifiers)

Start:
 67,956,137 bp from pter      End:
 67,997,436 bp from pter
Size:
 41,300 bases      Orientation:
 plus strand

Proteins
for SOCS6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SOCS6_HUMAN, O14544 (See protein sequence)
Recommended Name: Suppressor of cytokine signaling 6  
Size: 535 amino acids; 59528 Da
Subunit: Interacts with RBCK1. Interacts with phosphorylated IRS4 (By similarity). Interacts with PIM3 (By similarity).
Interacts with KIT (phosphorylated)
1 PDB 3D structure from and Proteopedia for SOCS6:
2VIF (3D)    
Secondary accessions: Q8WUM3

Explore the universe of human proteins at neXtProt for SOCS6: NX_O14544

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14544

    • SOCS6 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_004223.2  
    ENSEMBL proteins: 
     ENSP00000381034   ENSP00000463064   ENSP00000463395  
    Reactome Protein details: O14544
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SOCS6
    OriGene Custom Protein Services for SOCS6 
    GenScript Custom Purified and Recombinant Proteins Services for SOCS6
    Novus Biologicals SOCS6 Protein
    Novus Biologicals SOCS6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SOCS6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA--
    GO:0005737cytoplasm TAS9344848


    SOCS6 for ontologies           About GeneDecksing



    SOCS6 Antibody Products: 
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    Novus Biologicals SOCS6 Antibodies
    Search for Antibodies for SOCS6 at Abcam  
    Uscn Antibodies for SOCS6
    ThermoFisher Antibodies for SOCS6

    Assay Products for SOCS6: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SOCS6

    Protein Domains /
    Families
    for SOCS6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SOCS6 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001496 SOCS_C
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry O14544

    ProtoNet protein and cluster: O14544

    2 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001496 SOCS protein


    UniProtKB/Swiss-Prot: SOCS6_HUMAN, O14544
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3
    ubiquitin ligase complexes (By similarity)
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SOCS box domain


    Function
    for SOCS6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SOCS6_HUMAN, O14544
    Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
    transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
    proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor

    10/175 SABiosciences Target genes for SOCS6 (see all 175):
    ACCSL ACSM2A ADIG ADORA1 ADRB3 ALB ALG1 APBB2 ARID3B ASPHD2

    miRNA
    Products:            		miRTarBase miRNAs that target SOCS6:
    hsa-mir-98 (MIRT005326)

    OriGene 3'-UTR Clone: SOCS6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOCS6
    8/120 QIAGEN miScript miRNA Assays for microRNAs that regulate SOCS6 (see all 120):
    hsa-miR-300 hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SOCS6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOCS6 (see all 4)
    OriGene shRNA RFP: SOCS6
    OriGene siRNA: SOCS6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOCS6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SOCS6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOCS6 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOCS6 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SOCS6 (NM_004232)
    Sino Biological Human cDNA Clone for SOCS6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SOCS6
    Search LifeMap BioReagents cell lines for SOCS6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS6

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    SOCS6 for ontologies           About GeneDecksing


    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Socs6):
     growth/size  hematopoietic system  homeostasis/metabolism  immune system 

    SOCS6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SOCS6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PIP3 activates AKT signaling
    		Signaling by SCF-KIT0.72
    2Signaling by GPCR
    		Signal Transduction0.56
    3Phosphorylation of GAB2 by SFKs
    		Regulation of KIT signaling0.44
    4Signaling events mediated by Stem cell factor receptor (c-Kit)
    		Kit Receptor Signaling Pathway0.37
    5IL-9 Signaling Pathways
    		IL-9 Pathway0.22

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SOCS6
        IL-9 Pathway

    1 BioSystems Pathway for SOCS6 
        Kit Receptor Signaling Pathway

    3        Reactome Pathways for SOCS6
        Signal Transduction
    Regulation of KIT signaling
    Signaling by SCF-KIT


    UniProtKB/Swiss-Prot: SOCS6_HUMAN, O14544
    Pathway: Protein modification; protein ubiquitination


    SOCS6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SOCS6

    5/23 Interacting proteins for SOCS6 (O145443) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713I2D: score=3 
    BMPR1BO002383I2D: score=3 
    PIK3R1P279863I2D: score=3 
    PIK3R2O004593I2D: score=3 
    TGFBR1P368973I2D: score=3 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS9344848
    GO:0007259JAK-STAT cascade TAS9344848
    GO:0009968negative regulation of signal transduction IEA--
    GO:0010498proteasomal protein catabolic process IMP--
    GO:0016567protein ubiquitination IEA--


    SOCS6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SOCS6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOCS6
    Search CenterWatch for drugs/clinical trials and news about SOCS6 

    Transcripts
    for SOCS6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SOCS6 gene: 
    NM_004232.3  

    Unigene Cluster for SOCS6:

    Suppressor of cytokine signaling 6
    Hs.44439  [show with all ESTs]
    Unigene Representative Sequence: NM_004232
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397942(uc002lkr.1 uc010dqq.2) ENST00000578377 ENST00000582322


    miRNA
    Products:             		 OriGene 3'-UTR Clone: SOCS6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOCS6
    8/120 QIAGEN miScript miRNA Assays for microRNAs that regulate SOCS6 (see all 120):
    hsa-miR-300 hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SOCS6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOCS6 (see all 4)
    OriGene shRNA RFP: SOCS6
    OriGene siRNA: SOCS6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOCS6
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOCS6 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOCS6 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SOCS6 (NM_004232)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOCS6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SOCS6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOCS6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOCS6

    Additional cDNA sequence: 

    AB006968.1 AK024356.1 BC020082.1 

    6 DOTS entries:

    DT.95264618  DT.100890782  DT.100679557  DT.100771452  DT.40307376  DT.444895 

    24/109 AceView cDNA sequences (see all 109):

    AI382187 N48841 CB164425 BQ188776 BX957035 AL695425 BQ022878 AI685919 
    Z40663 AI091113 CA311534 BM722265 AA243026 BC020082 BU184436 BQ027376 
    CB137375 CA443150 BF477435 NM_004232 CF131623 BF594130 BU166877 CR601456 

    GeneLoc Exon Structure


    Expression
    for SOCS6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOCS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAACCTATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SOCS6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMedulla OblongataBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for SOCS6

    SOURCE GeneReport for Unigene cluster: Hs.44439
        SABiosciences Expression via Pathway-Focused PCR Array including SOCS6: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOCS6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS6

    Orthologs
    for SOCS6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SOCS6 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SOCS61 suppressor of cytokine signaling 6 83.15(n)
    90.45(a)    		   421020  NM_001127312.1  NP_001120784.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SOCS66
    		 --
    		 89(a)
    		 1 ↔ 1
    		 4(47148308-47149909)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.37452 Xenopus laevis transcribed sequence with strong similarity more 81.45(n)    BQ386670.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb77f062 wufb77f06 76.62(n)   322950  BC054619.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Socs44A6
    		 Suppressor of Cytokine Signaling at 44A
    		 20(a)
    		 possible ortholog
    		 2R(4015136-4016981)


    ENSEMBL Gene Tree for SOCS6 (if available)
    TreeFam Gene Tree for SOCS6 (if available) 

    Paralogs
    for SOCS6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOCS6 gene
    SOCS32  SOCS42  SOCS52  SOCS72  SOCS12  CISH2  SOCS22  
    1 SIMAP similar gene for SOCS6 using alignment to 2 protein entries:     SOCS6_HUMAN (see all proteins):
    SOCS2

    SOCS6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SOCS6
    PGOHUM00000242387 PGOHUM00000250052


    Genomic Variants
    for SOCS6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/883 NCBI SNPs in SOCS6 are shown (see all 883)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1470428701,2
    		--67954244(+) TCGAGC/TCCCCT 1 -- us2k10--------
    rs344903151,2
    		C,F,--67954345(+) CTGCAC/GCAGCT 1 -- us2k16Minor allele frequency- G:0.07NA WA EA 248
    rs1383161941,2
    		--67954444(+) GCTGCA/GTGAAA 1 -- us2k10--------
    rs1495794901,2
    		--67954461(+) CTAACC/TCCCTG 1 -- us2k10--------
    rs20623441,2
    		C,A,H,--67954520(-) CTCGGG/AGTTCC 1 -- us2k116Minor allele frequency- A:0.01NS EA NA WA CSA 792
    rs72389721,2
    		C,F,--67954597(+) CCCAGG/TCTGGA 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs72399641,2
    		C,F,--67954663(+) TCTCCC/TGCCTC 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1839833771,2
    		--67954754(+) ACTGTG/TTTGGC 1 -- us2k10--------
    rs1415481271,2
    		--67954801(+) CGCCTC/TGGCCT 1 -- us2k10--------
    rs414254511,2
    		C,--67954810(+) CTCCCA/GAAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SOCS6 (67956137 - 67997436 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SOCS6
         2 CNVs: 47912 7188

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOCS6
    DNA2.0 Custom Variant and Variant Library Synthesis for SOCS6

    Disorders / Diseases
    for SOCS6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SOCS6 for disorders           About GeneDecksing

    OMIM gene information: 605118    OMIM disorders: --

    14 diseases for SOCS6:    About MalaCards
    x-linked dystonia-parkinsonism    leukemia    mycosis fungoides    hypochondriasis
    systemic lupus erythematosus    lupus erythematosus    chronic lymphocytic leukemia    lymphocytic leukemia
    insulin resistance    rheumatoid arthritis    arthritis    gastric cancer
    asthma    retinitis

    1 Novoseek disease relationship for SOCS6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 12689942 (1), 12928496 (1)

    Human Genome Epidemiology (HuGE) Navigator: SOCS6 (6 documents)

    Export disorders for SOCS6 gene to outside databases

    Publications
    for SOCS6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOCS6 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with SOCS6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of novel CIS family genes. (PubMed id 9344848)1, 2, 3 Masuhara M.... Yoshimura A. (1997)
    2. Structural basis for c-KIT inhibition by the suppress or of cytokine signaling 6 (SOCS6) ubiquitin ligase. (PubMed id 21030588)1, 2 Zadjali F....Flores-Morales A. (2011)
    3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 3 Zhang Q.-H.... Chen Z. (2000)
    4. SOCS5 and SOCS6 have similar expression patterns in n ormal and cancer tissues. (PubMed id 22081311)1 Yoon S....Nam S.W. (2012)
    5. Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyro sines 591 and 919 of Flt3. (PubMed id 22952242)1 Kazi J.U....Ronnstrand L. (2012)
    6. Array-comparative genomic hybridization reveals loss o f SOCS6 is associated with poor prognosis in primary lung squamous cell carcinom a. (PubMed id 22363434)1 Sriram K.B....Fong K.M. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
    9. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    10. SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation. (PubMed id 20007709)1 Choi Y.B....Yun Y. (2010)

    External Searches for SOCS6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SOCS6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9306 HGNC: 16833 AceView: SOCS6 Ensembl:ENSG00000170677 euGenes: HUgn9306
    ECgene: SOCS6 H-InvDB: SOCS6

    Other Databases showing SOCS6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SOCS6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOCS6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOCS6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SOCS6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SOCS6 gene:
    Search GeneIP for patents involving SOCS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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