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Aliases for SOCS6 Gene

Aliases for SOCS6 Gene

  • Suppressor Of Cytokine Signaling 6 2 3 5
  • Suppressor Of Cytokine Signaling 4 2 3 4
  • Cytokine-Inducible SH2 Protein 4 3 4
  • SOCS-4 3 4
  • SOCS-6 3 4
  • SOCS4 3 4
  • CIS-4 3 4
  • CIS4 3 4
  • STAT Induced STAT Inhibitor-4 3
  • HSPC060 3
  • STATI4 3
  • STAI4 3
  • SSI4 3

External Ids for SOCS6 Gene

Previous HGNC Symbols for SOCS6 Gene

  • SOCS4

Previous GeneCards Identifiers for SOCS6 Gene

  • GC18P066106
  • GC18P066107
  • GC18P067956
  • GC18P064675

Summaries for SOCS6 Gene

Entrez Gene Summary for SOCS6 Gene

  • The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOCS6 Gene

SOCS6 (Suppressor Of Cytokine Signaling 6) is a Protein Coding gene. Among its related pathways are Prolactin Signaling Pathway and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. GO annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS7.

UniProtKB/Swiss-Prot for SOCS6 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

Gene Wiki entry for SOCS6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS6 Gene

Genomics for SOCS6 Gene

Regulatory Elements for SOCS6 Gene

Enhancers for SOCS6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F070418 1 FANTOM5 Ensembl ENCODE 21.4 +133.4 133424 8.2 PKNOX1 FEZF1 YY1 FOS JUNB PPARG KAT8 ATF4 SMARCA4 ETV4 SOCS6 RTTN LARP7P3 CD226 RPS2P6
GH18F070375 1.4 Ensembl ENCODE 15 +92.1 92144 11.2 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 GATA2 FOS SOCS6 RTTN LINC01910 LOC102724895
GH18F070323 0.6 Ensembl ENCODE 12 +34.3 34267 0.3 GATAD2A CEBPB CEBPG ZNF644 RAD21 YY1 ATF3 CEBPA MAFK NFE2L2 SOCS6 GC18P070327
GH18F070193 0.5 ENCODE 11.4 -94.2 -94186 2.8 PKNOX1 BMI1 RAD21 ETV6 CREM ZNF654 CBFB CEBPB JUNB REST SOCS6 LOC105372180 GC18P070003
GH18F070363 0.8 Ensembl ENCODE 11.1 +76.3 76329 3.9 ELF3 ESRRA STAT1 JUN BHLHE40 TEAD4 CEBPB ZNF140 ZNF384 RAD21 SOCS6 RTTN LINC01910 LOC102724895
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SOCS6 on UCSC Golden Path with GeneCards custom track

Promoters for SOCS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000527903 500 2800 TBP ZNF48 ZBTB40 GLIS2 EGR1 SCRT2 ZNF263 REST SMARCB1 GLIS1

Genomic Location for SOCS6 Gene

Chromosome:
18
Start:
70,288,901 bp from pter
End:
70,330,200 bp from pter
Size:
41,300 bases
Orientation:
Plus strand

Genomic View for SOCS6 Gene

Genes around SOCS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOCS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOCS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS6 Gene

Proteins for SOCS6 Gene

  • Protein details for SOCS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14544-SOCS6_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 6
    Protein Accession:
    O14544
    Secondary Accessions:
    • Q8WUM3

    Protein attributes for SOCS6 Gene

    Size:
    535 amino acids
    Molecular mass:
    59528 Da
    Quaternary structure:
    • Interacts with RBCK1. Interacts with phosphorylated IRS4 (By similarity). Interacts with PIM3 (By similarity). Interacts with KIT (phosphorylated).

    Three dimensional structures from OCA and Proteopedia for SOCS6 Gene

neXtProt entry for SOCS6 Gene

Post-translational modifications for SOCS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOCS6 Gene

No data available for DME Specific Peptides for SOCS6 Gene

Domains & Families for SOCS6 Gene

Protein Domains for SOCS6 Gene

Suggested Antigen Peptide Sequences for SOCS6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14544

UniProtKB/Swiss-Prot:

SOCS6_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 SH2 domain.
  • Contains 1 SOCS box domain.
genes like me logo Genes that share domains with SOCS6: view

Function for SOCS6 Gene

Molecular function for SOCS6 Gene

UniProtKB/Swiss-Prot Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

Gene Ontology (GO) - Molecular Function for SOCS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with SOCS6: view
genes like me logo Genes that share phenotypes with SOCS6: view

Animal Models for SOCS6 Gene

MGI Knock Outs for SOCS6:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SOCS6

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS6 Gene

Localization for SOCS6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOCS6 Gene COMPARTMENTS Subcellular localization image for SOCS6 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SOCS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 20007709
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm TAS 9344848
genes like me logo Genes that share ontologies with SOCS6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SOCS6 Gene

Pathways & Interactions for SOCS6 Gene

genes like me logo Genes that share pathways with SOCS6: view

Pathways by source for SOCS6 Gene

1 Sino Biological pathway for SOCS6 Gene
1 GeneTex pathway for SOCS6 Gene
1 BioSystems pathway for SOCS6 Gene
1 R&D Systems pathway for SOCS6 Gene
1 Qiagen pathway for SOCS6 Gene

UniProtKB/Swiss-Prot O14544-SOCS6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SOCS6 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for SOCS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0006952 defense response TAS 9344848
GO:0007259 JAK-STAT cascade TAS 9344848
GO:0009968 negative regulation of signal transduction IEA --
GO:0010498 proteasomal protein catabolic process IMP 20007709
genes like me logo Genes that share ontologies with SOCS6: view

Transcripts for SOCS6 Gene

Unigene Clusters for SOCS6 Gene

Suppressor of cytokine signaling 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SOCS6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS6 Gene

No ASD Table

Relevant External Links for SOCS6 Gene

GeneLoc Exon Structure for
SOCS6
ECgene alternative splicing isoforms for
SOCS6

Expression for SOCS6 Gene

mRNA expression in normal human tissues for SOCS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SOCS6 Gene



NURSA nuclear receptor signaling pathways regulating expression of SOCS6 Gene:

SOCS6

SOURCE GeneReport for Unigene cluster for SOCS6 Gene:

Hs.44439
genes like me logo Genes that share expression patterns with SOCS6: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SOCS6 Gene

Orthologs for SOCS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOCS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOCS6 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 95 (a)
OneToMany
LOC100856303 34
  • 89.6 (n)
-- 35
  • 83 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SOCS6 35
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Socs6 34
  • 80.57 (n)
mouse
(Mus musculus)
Mammalia Socs6 34 16 35
  • 80.38 (n)
oppossum
(Monodelphis domestica)
Mammalia SOCS6 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 65 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-6584 35
  • 90 (a)
OneToOne
SOCS6 34
  • 83.15 (n)
lizard
(Anolis carolinensis)
Reptilia SOCS6 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia socs6 34
  • 77.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3745 34
zebrafish
(Danio rerio)
Actinopterygii BX640518.1 35
  • 72 (a)
OneToMany
socs6b 35
  • 71 (a)
OneToMany
LOC558703 34
  • 68.47 (n)
wufb77f06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7466 34
fruit fly
(Drosophila melanogaster)
Insecta Socs44A 35
  • 25 (a)
ManyToMany
Socs16D 35
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8442 35
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.625 34
Species where no ortholog for SOCS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOCS6 Gene

ENSEMBL:
Gene Tree for SOCS6 (if available)
TreeFam:
Gene Tree for SOCS6 (if available)

Paralogs for SOCS6 Gene

Paralogs for SOCS6 Gene

(1) SIMAP similar genes for SOCS6 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SOCS6 Gene

genes like me logo Genes that share paralogs with SOCS6: view

Variants for SOCS6 Gene

Sequence variations from dbSNP and Humsavar for SOCS6 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1020161 -- 70,311,620(-) TAAAA(A/G)GGATC intron-variant
rs1020162 -- 70,311,393(-) CTTTC(C/T)TTAAT intron-variant
rs10451405 -- 70,305,263(+) atgac(A/C)cattt intron-variant
rs1047654 -- 70,325,031(+) AGGCC(A/G)ATAAG reference, synonymous-codon
rs1047657 -- 70,325,448(+) GGGCG(C/T)GCTTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SOCS6 Gene

Variant ID Type Subtype PubMed ID
dgv6061n54 CNV loss 21841781
esv32736 CNV gain+loss 17666407
esv34014 CNV loss 18971310
esv3642983 CNV loss 21293372
nsv1121954 CNV deletion 24896259
nsv1128832 CNV deletion 24896259
nsv960287 CNV duplication 23825009

Variation tolerance for SOCS6 Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOCS6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOCS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS6 Gene

Disorders for SOCS6 Gene

Relevant External Links for SOCS6

Genetic Association Database (GAD)
SOCS6
Human Genome Epidemiology (HuGE) Navigator
SOCS6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOCS6

No disorders were found for SOCS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOCS6 Gene

Publications for SOCS6 Gene

  1. Cloning and characterization of novel CIS family genes. (PMID: 9344848) Masuhara M. … Yoshimura A. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 64
  2. Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase. (PMID: 21030588) Zadjali F. … Flores-Morales A. (J. Biol. Chem. 2011) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. (PMID: 18204098) Hom G. … Behrens T.W. (N. Engl. J. Med. 2008) 3 46 64

Products for SOCS6 Gene

Sources for SOCS6 Gene

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