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Aliases for SOCS5 Gene

Aliases for SOCS5 Gene

  • Suppressor Of Cytokine Signaling 5 2 3
  • CIS6 3 4 6
  • Cytokine-Inducible SH2-Containing Protein 5 3 4
  • Cytokine-Inducible SH2 Protein 6 3 4
  • KIAA0671 4 6
  • SOCS-5 3 4
  • Cish5 3 4
  • CIS-6 3 4
  • CISH6 3 4

External Ids for SOCS5 Gene

Previous GeneCards Identifiers for SOCS5 Gene

  • GC02P046943
  • GC02P047094
  • GC02P046900
  • GC02P046837
  • GC02P046926
  • GC02P046663

Summaries for SOCS5 Gene

Entrez Gene Summary for SOCS5 Gene

  • The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOCS5 Gene

SOCS5 (Suppressor Of Cytokine Signaling 5) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include receptor tyrosine kinase binding and epidermal growth factor receptor binding. An important paralog of this gene is SOCS2.

UniProtKB/Swiss-Prot for SOCS5 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

Gene Wiki entry for SOCS5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS5 Gene

Genomics for SOCS5 Gene

Regulatory Elements for SOCS5 Gene

Genomic Location for SOCS5 Gene

Start:
46,698,952 bp from pter
End:
46,763,129 bp from pter
Size:
64,178 bases
Orientation:
Plus strand

Genomic View for SOCS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOCS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS5 Gene

Proteins for SOCS5 Gene

  • Protein details for SOCS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75159-SOCS5_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 5
    Protein Accession:
    O75159
    Secondary Accessions:
    • Q53SD4
    • Q8IYZ4

    Protein attributes for SOCS5 Gene

    Size:
    536 amino acids
    Molecular mass:
    61246 Da
    Quaternary structure:
    • Interacts with IL4R; inhibits IL4 signaling (By similarity). Interacts with EGFR. Interacts with TCEB1 AND TCEB2; mediates EGFR ubiquitination and degradation.
    SequenceCaution:
    • Sequence=BAA31646.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SOCS5 Gene

Proteomics data for SOCS5 Gene at MOPED

Post-translational modifications for SOCS5 Gene

Other Protein References for SOCS5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOCS5 Gene

Domains for SOCS5 Gene

Gene Families for SOCS5 Gene

HGNC:
  • SH2D :SH2 domain containing
  • SOCS :Suppressors of cytokine signaling

Protein Domains for SOCS5 Gene

Graphical View of Domain Structure for InterPro Entry

O75159

UniProtKB/Swiss-Prot:

SOCS5_HUMAN :
  • O75159
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes
  • Contains 1 SH2 domain.
  • Contains 1 SOCS box domain.
genes like me logo Genes that share domains with SOCS5: view

Function for SOCS5 Gene

Molecular function for SOCS5 Gene

UniProtKB/Swiss-Prot Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
UniProtKB/Swiss-Prot Induction: Up-regulated by EGF (at protein level).

Gene Ontology (GO) - Molecular Function for SOCS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005515 protein binding IPI 15590694
GO:0030971 receptor tyrosine kinase binding IPI 15590694
genes like me logo Genes that share ontologies with SOCS5: view
genes like me logo Genes that share phenotypes with SOCS5: view

Animal Models for SOCS5 Gene

MGI Knock Outs for SOCS5:

miRNA for SOCS5 Gene

miRTarBase miRNAs that target SOCS5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SOCS5 Gene

Localization for SOCS5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOCS5 Gene COMPARTMENTS Subcellular localization image for SOCS5 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SOCS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SOCS5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SOCS5 Gene

Pathways for SOCS5 Gene

genes like me logo Genes that share pathways with SOCS5: view

Pathways by source for SOCS5 Gene

1 GeneGo (Thomson Reuters) pathway for SOCS5 Gene

UniProtKB/Swiss-Prot O75159-SOCS5_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SOCS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway IEA --
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity IDA 15590694
GO:0007259 JAK-STAT cascade IEA --
GO:0009968 negative regulation of signal transduction NAS 10773671
GO:0016049 cell growth NAS 11837794
genes like me logo Genes that share ontologies with SOCS5: view

Transcripts for SOCS5 Gene

mRNA/cDNA for SOCS5 Gene

Unigene Clusters for SOCS5 Gene

Suppressor of cytokine signaling 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS5 Gene

No ASD Table

Relevant External Links for SOCS5 Gene

GeneLoc Exon Structure for
SOCS5
ECgene alternative splicing isoforms for
SOCS5

Expression for SOCS5 Gene

mRNA expression in normal human tissues for SOCS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOCS5 Gene

SOURCE GeneReport for Unigene cluster for SOCS5 Gene Hs.468426

genes like me logo Genes that share expressions with SOCS5: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SOCS5 Gene

Orthologs for SOCS5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOCS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOCS5 35
  • 99.69 (n)
  • 100 (a)
SOCS5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SOCS5 35
  • 92.72 (n)
  • 97.76 (a)
SOCS5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOCS5 35
  • 92.29 (n)
  • 97.57 (a)
SOCS5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Socs5 35
  • 87.56 (n)
  • 94.4 (a)
Socs5 16
Socs5 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SOCS5 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Socs5 35
  • 87.38 (n)
  • 95.15 (a)
chicken
(Gallus gallus)
Aves SOCS5 35
  • 81.65 (n)
  • 91.04 (a)
SOCS5 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOCS5 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11517 35
tropical clawed frog
(Silurana tropicalis)
Amphibia socs5 35
  • 74.03 (n)
  • 81.09 (a)
Str.4500 35
zebrafish
(Danio rerio)
Actinopterygii socs5a 36
  • 63 (a)
OneToMany
socs5b 35
  • 64.96 (n)
  • 72.69 (a)
socs5b 36
  • 64 (a)
OneToMany
socs9 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Socs36E 36
  • 26 (a)
OneToMany
Socs36E 37
  • 69 (a)
Species with no ortholog for SOCS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOCS5 Gene

ENSEMBL:
Gene Tree for SOCS5 (if available)
TreeFam:
Gene Tree for SOCS5 (if available)

Paralogs for SOCS5 Gene

Paralogs for SOCS5 Gene

Selected SIMAP similar genes for SOCS5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOCS5: view

Variants for SOCS5 Gene

Sequence variations from dbSNP and Humsavar for SOCS5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs714738 -- 46,715,059(-) AAGCA(A/G)AAAGA intron-variant
rs897528 -- 46,722,198(-) AAACT(C/T)TAGAC intron-variant
rs897529 -- 46,721,036(-) AAAGG(A/G)CATTT intron-variant
rs897530 -- 46,721,011(-) GATTT(C/G)GATTT intron-variant
rs973491 -- 46,703,637(-) AATGT(A/G)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SOCS5 Gene

Variant ID Type Subtype PubMed ID
nsv873996 CNV Gain 21882294
nsv873997 CNV Loss 21882294
esv2578626 CNV Insertion 19546169
esv269673 CNV Insertion 20981092
esv273266 CNV Insertion 20981092
esv2639866 CNV Deletion 19546169
esv25338 CNV Loss 19812545

Relevant External Links for SOCS5 Gene

HapMap Linkage Disequilibrium report
SOCS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS5 Gene

Disorders for SOCS5 Gene

(1) University of Copenhagen DISEASES for SOCS5 Gene

Relevant External Links for SOCS5

Genetic Association Database (GAD)
SOCS5
Human Genome Epidemiology (HuGE) Navigator
SOCS5
genes like me logo Genes that share disorders with SOCS5: view

No data available for UniProtKB/Swiss-Prot for SOCS5 Gene

Publications for SOCS5 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. Cloning and expression of CIS6, chromosomal assignment to 3p22 and 2p21 by in situ hybridization. (PMID: 10773671) Magrangeas F. … Minvielle S. (Cytogenet. Cell Genet. 2000) 3 4 23
  4. Genome-wide association study of smoking behaviours in patients with COPD. (PMID: 21685187) Siedlinski M. … . (Thorax 2011) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SOCS5 Gene

Sources for SOCS5 Gene

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