Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SOCS5 Gene

protein-coding   GIFtS: 64
GCID: GC02P046926

Suppressor Of Cytokine Signaling 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Suppressor Of Cytokine Signaling 51 2     CISH62 3
CIS62 3 5     SOCS-52 3
Cytokine-Inducible SH2 Protein 62 3     KIAA06713 5
Cytokine-Inducible SH2-Containing Protein 52 3     Cish52
CIS-62 3     CISH53

External Ids:    HGNC: 168521   Entrez Gene: 96552   Ensembl: ENSG000001711507   OMIM: 6070945   UniProtKB: O751593   

Export aliases for SOCS5 gene to outside databases

Previous GC identifers: GC02P046943 GC02P047094 GC02P046900 GC02P046837 GC02P046663


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SOCS5 Gene:
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the
suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family.
SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific
function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an
identical protein have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOCS5 Gene:
SOCS5 (suppressor of cytokine signaling 5) is a protein-coding gene. Diseases associated with SOCS5 include allergic conjunctivitis, and vogt-koyanagi-harada disease. GO annotations related to this gene include epidermal growth factor receptor binding and receptor tyrosine kinase binding. An important paralog of this gene is SOCS3.

UniProtKB/Swiss-Prot: SOCS5_HUMAN, O75159
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR.
Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which
promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling

Gene Wiki entry for SOCS5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOCS5 gene promoter:
         NF-AT4   NF-AT2   NF-AT3   PPAR-gamma2   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOCS5 promoter sequence
   Search Chromatin IP Primers for SOCS5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOCS5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p21

SOCS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P046926:  view genomic region     (about GC identifiers)

Start:
46,926,091 bp from pter      End:
46,990,268 bp from pter
Size:
64,178 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SOCS5_HUMAN, O75159 (See protein sequence)
Recommended Name: Suppressor of cytokine signaling 5  
Size: 536 amino acids; 61246 Da
Subunit: Interacts with IL4R; inhibits IL4 signaling (By similarity). Interacts with EGFR. Interacts with TCEB1
AND TCEB2; mediates EGFR ubiquitination and degradation
Sequence caution: Sequence=BAA31646.2; Type=Erroneous initiation;
Secondary accessions: Q53SD4 Q8IYZ4

Explore the universe of human proteins at neXtProt for SOCS5: NX_O75159

Explore proteomics data for SOCS5 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is induced by EGF1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOCS5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_054730.1  NP_659198.1  

    ENSEMBL proteins: 
     ENSP00000305133   ENSP00000378330  

    SOCS5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SOCS5
    OriGene Protein Over-expression Lysate for SOCS5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SOCS5
    GenScript Custom Purified and Recombinant Proteins Services for SOCS5
    Novus Biologicals SOCS5 Proteins
    Novus Biologicals SOCS5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOCS5

    SOCS5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SOCS5 (SOCS-5)
    OriGene Antibodies for SOCS5
    OriGene Custom Antibody Services for SOCS5
    Novus Biologicals SOCS5 Antibodies
    Abcam antibodies for SOCS5
    Cloud-Clone Corp. Antibodies for SOCS5
    ThermoFisher Antibodies for SOCS5
    LSBio Antibodies in human, mouse, rat for SOCS5

    SOCS5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SOCS5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SOCS5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOCS5
    Cloud-Clone Corp. CLIAs for SOCS5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SOCS: Suppressors of cytokine signaling
    SH2D: SH2 domain containing

    5 InterPro protein domains:
     IPR001496 SOCS_C
     IPR000980 SH2
     IPR028420 SOCS5
     IPR028413 SOCS
     IPR022252 SOCS4/SOCS5_dom

    Graphical View of Domain Structure for InterPro Entry O75159

    ProtoNet protein and cluster: O75159

    1 Blocks protein domain: IPB001496 SOCS protein

    UniProtKB/Swiss-Prot: SOCS5_HUMAN, O75159
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SOCS box domain


    SOCS5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOCS5_HUMAN, O75159
    Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
    transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR.
    Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which
    promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling
    Induction: Up-regulated by EGF (at protein level)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005154epidermal growth factor receptor binding IEA--
    GO:0005515protein binding IPI15590694
    GO:0030971receptor tyrosine kinase binding IPI15590694
         
    SOCS5 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Socs5):
     endocrine/exocrine gland  integument  normal  reproductive system 

    SOCS5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Socs5tm1Wsa for SOCS5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOCS5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOCS5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOCS5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOCS5

    miRNA
    Products:
        
    miRTarBase miRNAs that target SOCS5:
    hsa-mir-16-5p (MIRT051149), hsa-mir-21-5p (MIRT002412), hsa-mir-9-5p (MIRT007035)

    Block miRNA regulation of human, mouse, rat SOCS5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOCS5 (see all 23):
    hsa-miR-448 hsa-miR-300 hsa-miR-4299 hsa-miR-301a hsa-miR-371-5p hsa-miR-218 hsa-miR-9 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSOCS5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOCS5
    Predesigned siRNA for gene silencing in human, mouse, rat SOCS5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SOCS5

    Clone
    Products:
         
    OriGene clones in human, mouse for SOCS5 (see all 11)
    OriGene ORF clones in mouse, rat for SOCS5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SOCS5 (NM_014011)
    Sino Biological Human cDNA Clone for SOCS5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SOCS5
    Browse ESI BIO Cell Lines and PureStem Progenitors for SOCS5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SOCS5 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1ErbB4 Pathway
    Prolactin Signaling0.54
    IL-4 Pathway0.34
    Growth Hormone Signaling0.49
    2PEDF Induced Signaling
    IL-6 Pathway0.61
    STAT3 Pathway0.47
    3TGF-Beta Pathway
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Development IGF 1 receptor signaling
    Immune response IL 4 signaling pathway0.39
    5Kit Receptor Signaling Pathway
    Kit Receptor Signaling Pathway0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SOCS5 (see all 8)
        IL-9 Pathway
    Growth Hormone Signaling
    STAT3 Pathway
    IL-4 Pathway
    Prolactin Signaling

    1 GeneGo (Thomson Reuters) Pathway for SOCS5
        Immune response IL-4 signaling pathway

    3 BioSystems Pathways for SOCS5
        IL-4 signaling Pathway
    Kit Receptor Signaling Pathway
    IL4-mediated signaling events



    2 Kegg Pathways  (Kegg details for SOCS5):
        Jak-STAT signaling pathway
    Prolactin signaling pathway

    UniProtKB/Swiss-Prot: SOCS5_HUMAN, O75159
    Pathway: Protein modification; protein ubiquitination


    SOCS5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOCS5: 

              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SOCS5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SOCS5 (O751592, 3 ENSP000003051334) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEB1Q153692, 3, ENSP000002848114MINT-2835808 I2D: score=2 STRING: ENSP00000284811
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    KITP107213, ENSP000002881354I2D: score=1 STRING: ENSP00000288135
    EGFRP005333, ENSP000002754934I2D: score=3 STRING: ENSP00000275493
    IL4RP243943, ENSP000001706304I2D: score=3 STRING: ENSP00000170630
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway IEA--
    GO:0007175negative regulation of epidermal growth factor-activated receptor activity IDA15590694
    GO:0007259JAK-STAT cascade ----
    GO:0009968negative regulation of signal transduction NAS10773671
    GO:0016049cell growth NAS11837794

    SOCS5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOCS5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SOCS5 gene (2 alternative transcripts): 
    NM_014011.4  NM_144949.2  

    Unigene Cluster for SOCS5:

    Suppressor of cytokine signaling 5
    Hs.468426  [show with all ESTs]
    Unigene Representative Sequence: NM_144949
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306503(uc002rvf.3 uc002rvg.3) ENST00000394861
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SOCS5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOCS5 (see all 23):
    hsa-miR-448 hsa-miR-300 hsa-miR-4299 hsa-miR-301a hsa-miR-371-5p hsa-miR-218 hsa-miR-9 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSOCS5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SOCS5
    Predesigned siRNA for gene silencing in human, mouse, rat SOCS5
    Clone
    Products:
         
    OriGene clones in human, mouse for SOCS5 (see all 11)
    OriGene ORF clones in mouse, rat for SOCS5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SOCS5 (NM_014011)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SOCS5
    OriGene qSTAR qPCR primer pairs in human, mouse for SOCS5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOCS5
      QuantiTect SYBR Green Assays in human, mouse, rat SOCS5
      QuantiFast Probe-based Assays in human, mouse, rat SOCS5

    Additional mRNA sequence: 

    AB014571.1 AF073958.1 AK290194.1 AK296796.1 AL136896.1 BC032862.1 

    5 DOTS entries:

    DT.440803  DT.95342969  DT.95222954  DT.95163970  DT.120829691 

    Selected AceView cDNA sequences (see all 94):

    AW196048 AL136896 AA971583 BQ881514 T17373 AA583249 BM973647 NM_014011 
    R80422 AI826316 AI088496 AF073958 BU625772 AB014571 NM_144949 AW262882 
    BM993963 CA435702 BM955863 AL039592 AA411972 AV723242 BC032862 AA992978 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SOCS5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTGCACC
    SOCS5 Expression
    About this image


    SOCS5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SOCS5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOCS5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.468426
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOCS5: 
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SOCS5
    OriGene qSTAR qPCR primer pairs in human, mouse for SOCS5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOCS5
    QuantiTect SYBR Green Assays in human, mouse, rat SOCS5
    QuantiFast Probe-based Assays in human, mouse, rat SOCS5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SOCS5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Socs51 , 5 suppressor of cytokine signaling 51, 5 87.56(n)1
    94.4(a)1
      17 (56.93 cM)5
    564681  NM_019654.21  NP_062628.21 
     871076795 
    chicken
    (Gallus gallus)
    Aves SOCS51 suppressor of cytokine signaling 5 81.65(n)
    91.04(a)
      428570  NM_001127314.1  NP_001120786.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOCS56
    suppressor of cytokine signaling 5
    86(a)
    1 ↔ 1
    2(142930592-142932190)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115172 Xenopus laevis transcribed sequence with strong similarity more 75.85(n)    BX848217.1 
    zebrafish
    (Danio rerio)
    Actinopterygii socs5b1 suppressor of cytokine signaling 5b 64.96(n)
    72.69(a)
      559639  NM_001113797.1  NP_001107269.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Socs36E3 JAK-STAT cascade 69(a)   36D3   --


    ENSEMBL Gene Tree for SOCS5 (if available)
    TreeFam Gene Tree for SOCS5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SOCS5 gene
    SOCS32  SOCS42  SOCS72  SOCS12  SOCS62  CISH2  SOCS22  
    2 SIMAP similar genes for SOCS5 using alignment to 1 protein entry:     SOCS5_HUMAN:
    DKFZp686J1568    SOCS4

    SOCS5 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for SOCS5 (see all 6)
    PGOHUM00000237608 PGOHUM00000243746 PGOHUM00000232908 PGOHUM00000249776 PGOHUM00000236788


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SOCS5 (see all 1439)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs351876671,2
    C--46681036(+) TTTTT-/T/TT  
            
    GCATA
    2 -- int11NA 2
    rs67219991,2
    C,F--46924172(+) ATAGAG/AGAAAG 1 -- us2k1 tfbs32Minor allele frequency- A:0.05WA EA 238
    rs413298451,2
    C--46924245(+) TTGGAC/GAGTAA 1 -- us2k10--------
    rs178219891,2
    C,F--46924254(+) AAGAAG/AAAAGC 1 -- us2k1 trp34Minor allele frequency- A:0.07NA 262
    rs1405256641,2
    --46924361(+) TTCCCC/TGAATT 2 -- us2k10--------
    rs414164461,2
    C--46924369(+) ATTATC/GTCATT 2 -- us2k10--------
    rs11093801,2
    C--46924490(-) CTTAAC/ATGAGC 2 -- us2k18Minor allele frequency- A:0.20NA EA WA 611
    rs1442159021,2
    C--46924536(+) TGGCA-/GGGGG 
     GGGGGGG
    GTGGC
    2 -- cds10--------
    rs1882888341,2
    --46924641(+) TGAAAC/GGTTAC 2 -- us2k10--------
    rs1808337651,2
    --46924650(+) ACTTCA/GAGGTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SOCS5 (46926091 - 46990268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SOCS5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2639866CNV Deletion19546169
    esv273266CNV Insertion20981092
    esv269673CNV Insertion20981092
    esv2578626CNV Insertion19546169
    nsv873997CNV Loss21882294
    esv25338CNV Loss19812545
    nsv873996CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOCS5
    DNA2.0 Custom Variant and Variant Library Synthesis for SOCS5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607094    OMIM disorders: --

    11 diseases for SOCS5:    
    About MalaCards
    allergic conjunctivitis    vogt-koyanagi-harada disease    conjunctivitis    type 1 diabetes mellitus
    atopic dermatitis    dermatitis    chronic lymphocytic leukemia    type 1 diabetes
    diabetes mellitus    endotheliitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for SOCS5:
    Allergic conjunctivitis

    SOCS5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SOCS5
    Human Genome Epidemiology (HuGE) Navigator: SOCS5 (4 documents)

    Export disorders for SOCS5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SOCS5 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with SOCS5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    3. Cloning and expression of CIS6, chromosomal assignment to 3p22 and 2p21 by in situ hybridization. (PubMed id 10773671)1, 2, 9 Magrangeas F....Minvielle S. (Cytogenet. Cell Genet. 2000)
    4. Genome-wide association study of smoking behaviours in patients with COPD. (PubMed id 21685187)1, 4 Siedlinski M.... . (Thorax 2011)
    5. A multiplex MALDI-TOF MS approach facilitates genotyping of DNA from formalin-fixed paraffin-embedded tumour specimens. (PubMed id 20802378)1, 4 Horn H....Schaeffeler E. (Pharmacogenet. Genomics 2010)
    6. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. (PubMed id 15590694)1, 2 Kario E.... Yarden Y. (J. Biol. Chem. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. [Association of polymorphism Rs6737848 in the Socs5 gene with bronchial asthma]. (PubMed id 24340963)1 Saltykova I.V....Puzyrev V.P. (Vestn. Akad. Med. Nauk SSSR 2013)
    9. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    10. The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5. (PubMed id 22423360)1 Feng Z.P....Norton R.S. (Proteins 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9655 HGNC: 16852 AceView: SOCS5 Ensembl:ENSG00000171150 euGenes: HUgn9655
    ECgene: SOCS5 Kegg: 9655 H-InvDB: SOCS5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0671

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SOCS5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SOCS5 gene:
    Search GeneIP for patents involving SOCS5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for SOCS5 (SOCS-5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SOCS5   OriGene RNAi products in human, mouse, rat for SOCS5  
     OriGene qPCR primer pairs and template standards for SOCS5   OriGene Protein Over-expression Lysate for SOCS5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SOCS5  
     OriGene qSTAR qPCR primer pairs in human, mouse for SOCS5   OriGene Purified Protein for SOCS5  
     OriGene ORF clones in mouse, rat for SOCS5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SOCS5   OriGene Custom Protein Services for SOCS5  

     
     
     Block miRNA regulation of human, mouse, rat SOCS5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SOCS5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOCS5 Predesigned siRNA for gene silencing in human, mouse, rat SOCS5
     QuantiFast Probe-based Assays in human, mouse, rat SOCS5 QuantiTect SYBR Green Assays in human, mouse, rat SOCS5
     PCR Arrays including human, mouse, rat SOCS5 Search Chromatin IP Primers for SOCS5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOCS5  GeneGlobe Interaction Network for SOCS5
     Regulatory tfbs in SOCS5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SOCS5 GenScript cDNA clones with any tag delivered in your preferred vector for SOCS5
     GenScript Custom Assay Services for SOCS5 GenScript Custom overexpressing Cell Line Services for SOCS5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SOCS5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SOCS5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SOCS5 antibodies
     SOCS5 proteins
     SOCS5 lysates
     Antibodies for SOCS5
     See all of Abcam's Antibodies, Kits and Proteins for SOCS5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SOCS5
     Antibodies for SOCS5
     ELISAs for SOCS5
     CLIAs for SOCS5



     Browse ESI BIO Cell Lines and PureStem Progenitors for SOCS5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS5
     SwitchGear 3'UTR luciferase reporter plasmids for SOCS5
     SwitchGear Promoter luciferase reporter plasmids for SOCS5
     ThermoFisher Antibodies for SOCS5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOCS5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOCS5
     LSBio Antibodies in human, mouse, rat for SOCS5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SOCS5 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4