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SOCS4 Gene

protein-coding   GIFtS: 57
GCID: GC14P055493

Suppressor Of Cytokine Signaling 4

(Previous name: suppressor of cytokine signaling 7)
(Previous symbol: SOCS7)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Cytokine Signaling 41 2     SH2 Domain Containing SOCS Box Protein2
Suppressor Of Cytokine Signaling 71 2 3     CIS45
SOCS71 2 3     SSI45
SOCS-42 3     STAT45
SOCS-72 3     

External Ids:    HGNC: 193921   Entrez Gene: 1228092   Ensembl: ENSG000001800087   OMIM: 6051185   UniProtKB: Q8WXH53   

Export aliases for SOCS4 gene to outside databases

Previous GC identifers: GC14P052833 GC18P068015 GC18P067741 GC18P066105 GC14P053484 GC14P054563 GC14P035656


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOCS4 Gene:
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the
suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS
family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively
spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for SOCS4 Gene:
SOCS4 (suppressor of cytokine signaling 4) is a protein-coding gene. An important paralog of this gene is SOCS3.

UniProtKB/Swiss-Prot: SOCS4_HUMAN, Q8WXH5
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SOCS4 gene promoter:
         AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   CREB   AREB6   STAT3   SEF-1 (1)   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOCS4 promoter sequence
   Search Chromatin IP Primers for SOCS4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOCS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.2   HGNC cytogenetic band: 14q22.1

SOCS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P055493:  view genomic region     (about GC identifiers)

Start:
55,493,844 bp from pter      End:
55,516,207 bp from pter
Size:
22,364 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SOCS4_HUMAN, Q8WXH5 (See protein sequence)
Recommended Name: Suppressor of cytokine signaling 4  
Size: 440 amino acids; 50623 Da
1 PDB 3D structure from and Proteopedia for SOCS4:
2IZV (3D)    

Explore the universe of human proteins at neXtProt for SOCS4: NX_Q8WXH5

Explore proteomics data for SOCS4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOCS4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_543143.1  NP_955453.1  

    ENSEMBL proteins: 
     ENSP00000378855   ENSP00000452522   ENSP00000341327  

    SOCS4 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SOCS4
    GenScript Custom Purified and Recombinant Proteins Services for SOCS4
    Novus Biologicals SOCS4 Protein
    Novus Biologicals SOCS4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOCS4

     
    Search eBioscience for Proteins for SOCS4 

     
    antibodies-online proteins for SOCS4 (2 products) 

     
    antibodies-online peptides for SOCS4

    SOCS4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SOCS4 (SOCS-4)
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    Novus Biologicals SOCS4 Antibodies
    Abcam antibodies for SOCS4
    Cloud-Clone Corp. Antibodies for SOCS4
    ThermoFisher Antibodies for SOCS4
    antibodies-online antibodies for SOCS4 (37 products) 

    SOCS4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SOCS4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOCS4
    Cloud-Clone Corp. CLIAs for SOCS4
    Search eBioscience for ELISAs for SOCS4 
    antibodies-online kits for SOCS4 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SOCS: Suppressors of cytokine signaling
    SH2D: SH2 domain containing

    5 InterPro protein domains:
     IPR001496 SOCS_C
     IPR000980 SH2
     IPR028416 SOCS4
     IPR028413 SOCS
     IPR022252 SOCS4/SOCS5_dom

    Graphical View of Domain Structure for InterPro Entry Q8WXH5

    ProtoNet protein and cluster: Q8WXH5

    1 Blocks protein domain: IPB001496 SOCS protein

    UniProtKB/Swiss-Prot: SOCS4_HUMAN, Q8WXH5
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes (By similarity)
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SOCS box domain


    Find genes that share domains with SOCS4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOCS4_HUMAN, Q8WXH5
    Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
    transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR
    Induction: Up-regulated by EGF

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SOCS4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SOCS4:
     Increased cell death HMECs cel  Increased circadian period len 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SOCS4

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for SOCS4 (see all 165):
    ACCSL,  ACSM2A,  ADIG,  ADORA1,  ADRB3,  ALB,  ALG1,  APBB2,  ARID3B,  ASPHD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SOCS4:
    hsa-mir-34a-5p (MIRT025579), hsa-mir-21-5p (MIRT031056), hsa-mir-615-3p (MIRT040330), hsa-mir-19b-3p (MIRT031212), hsa-mir-98-5p (MIRT005326), hsa-mir-130b-3p (MIRT020274)

    Block miRNA regulation of human, mouse, rat SOCS4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOCS4 (see all 75):
    hsa-miR-607 hsa-miR-376b hsa-miR-4272 hsa-miR-1245 hsa-miR-374a hsa-miR-4273 hsa-miR-34c-5p hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOCS4
    Predesigned siRNA for gene silencing in human, mouse, rat SOCS4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SOCS4

    Clone
    Products:
         
    OriGene clones in human, mouse for SOCS4 (see all 11)
    OriGene ORF clones in mouse, rat for SOCS4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SOCS4 (NM_080867)
    Sino Biological Human cDNA Clone for SOCS4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SOCS4
    Browse ESI BIO Cell Lines and PureStem Progenitors for SOCS4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOCS4 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Type II diabetes mellitus
    Type II diabetes mellitus0.38
    Type II diabetes mellitus0.35
    2ErbB4 Pathway
    Prolactin Signaling0.54
    IL-4 Pathway0.34
    Growth Hormone Signaling0.49
    3PEDF Induced Signaling
    IL-6 Pathway0.61
    STAT3 Pathway0.47
    4TGF-Beta Pathway
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Kit Receptor Signaling Pathway
    Kit Receptor Signaling Pathway0.37


    Find genes that share SuperPaths with SOCS4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SOCS4 (see all 7)
        Growth Hormone Signaling
    STAT3 Pathway
    IL-4 Pathway
    JAK-STAT Pathway
    Prolactin Signaling

    2 BioSystems Pathways for SOCS4
        Type II diabetes mellitus
    Kit Receptor Signaling Pathway



    4 Kegg Pathways  (Kegg details for SOCS4):
        Jak-STAT signaling pathway
    Insulin signaling pathway
    Prolactin signaling pathway
    Type II diabetes mellitus

    UniProtKB/Swiss-Prot: SOCS4_HUMAN, Q8WXH5
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOCS4: 

              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SOCS4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SOCS4 (Q8WXH52, 3 ENSP000003413274) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEB1Q153692, 3, ENSP000002848114MINT-2835855 I2D: score=1 STRING: ENSP00000284811
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    JAK2O606743, ENSP000003710674I2D: score=1 STRING: ENSP00000371067
    KITP107213I2D: score=1 
    TCEB2ENSP000002623064STRING: ENSP00000262306
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007175negative regulation of epidermal growth factor-activated receptor activity IDA15590694
    GO:0016567protein ubiquitination IEA--
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process ----
    GO:0035556intracellular signal transduction IEA--
    GO:0040008regulation of growth IEA--

    Find genes that share ontologies with SOCS4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOCS4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOCS4 gene (2 alternative transcripts): 
    NM_080867.2  NM_199421.1  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395472(uc001xbo.3 uc001xbp.3) ENST00000555846 ENST00000553735
    ENST00000339298
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SOCS4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOCS4 (see all 75):
    hsa-miR-607 hsa-miR-376b hsa-miR-4272 hsa-miR-1245 hsa-miR-374a hsa-miR-4273 hsa-miR-34c-5p hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SOCS4
    Predesigned siRNA for gene silencing in human, mouse, rat SOCS4
    Clone
    Products:
         
    OriGene clones in human, mouse for SOCS4 (see all 11)
    OriGene ORF clones in mouse, rat for SOCS4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SOCS4 (NM_080867)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SOCS4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOCS4
      QuantiTect SYBR Green Assays in human, mouse, rat SOCS4
      QuantiFast Probe-based Assays in human, mouse, rat SOCS4

    Selected AceView cDNA sequences (see all 121):

    NM_199421 BU951909 BQ446934 NM_080867 AW130886 AI653056 AI472184 BC060790 
    BU741261 AI082443 AK126195 BU686061 AI000715 AF424815 BI492088 AI348677 
    BU786158 CB045775 AK056685 BX648734 BM479640 BG564397 BG399272 BF446961 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SOCS4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for SOCS4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOCS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTCGAATA
    SOCS4 Expression
    About this image


    SOCS4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
    SOCS4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOCS4 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOCS4: 
              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SOCS4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOCS4
    QuantiTect SYBR Green Assays in human, mouse, rat SOCS4
    QuantiFast Probe-based Assays in human, mouse, rat SOCS4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SOCS4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Socs41 , 5 suppressor of cytokine signaling 41, 5 86.31(n)1
    87.39(a)1
      14 (24.60 cM)5
    672961  NM_080843.21  NP_543119.21 
     472769315 
    chicken
    (Gallus gallus)
    Aves SOCS41 suppressor of cytokine signaling 4 74.87(n)
    79.54(a)
      423557  NM_001199108.1  NP_001186037.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOCS46
    suppressor of cytokine signaling 4
    80(a)
    1 ↔ 1
    GL343325.1(84216-85526)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX745222.12   -- 74.95(n)    BX745222.1 
    zebrafish
    (Danio rerio)
    Actinopterygii socs91 suppressor of cytokine signaling 9 50.2(n)
    50.84(a)
      100003691  NM_001113801.1  NP_001107273.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Socs36E3 JAK-STAT cascade 66(a)   36D3   --


    ENSEMBL Gene Tree for SOCS4 (if available)
    TreeFam Gene Tree for SOCS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOCS4 gene
    SOCS32  SOCS52  SOCS72  SOCS12  SOCS62  CISH2  SOCS22  
    2 SIMAP similar genes for SOCS4 using alignment to 1 protein entry:     SOCS4_HUMAN:
    DKFZp686J1568    SOCS5

    Find genes that share paralogs with SOCS4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOCS4 (see all 398)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924215901,2
    --55495862(+) TTCAGA/TGAGTT 2 -- int10--------
    rs765185141,2
    C,F--55495866(+) GTGAGT/ATTATG 2 -- int11Minor allele frequency- A:0.07NA 120
    rs797419501,2
    --55495918(+) ATGATA/GGTGCA 2 -- int10--------
    rs1853863861,2
    --55495969(+) TAGTTA/GGTTAA 2 -- int10--------
    rs1883508531,2
    --55496087(+) TGTGGA/GTGGCT 2 -- int10--------
    rs12126411,2
    C,F,A,H--55496131(-) CAATTG/CAATCT 2 -- int115Minor allele frequency- C:0.29MN NS EA NA WA CSA 880
    rs1169059581,2
    C,F--55496248(+) TGCCAT/CTCTAC 2 -- int11Minor allele frequency- C:0.01NA 120
    rs1166520511,2
    F--55496256(+) TACCAA/GTGATG 2 -- int11Minor allele frequency- G:0.03WA 118
    rs1929373621,2
    --55496365(+) AAATAG/TGTACT 2 -- int10--------
    rs1382492151,2
    --55496654(+) CCAGTA/GTTTGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for SOCS4 (55493844 - 55516207 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SOCS4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv84529CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOCS4
    DNA2.0 Custom Variant and Variant Library Synthesis for SOCS4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605118    OMIM disorders: --


    Find genes that share disorders with SOCS4           About GenesLikeMe

    Genetic Association Database (GAD): SOCS4
    Human Genome Epidemiology (HuGE) Navigator: SOCS4 (10 documents)

    Export disorders for SOCS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOCS4 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SOCS4)
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    1. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    2. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    3. Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. (PubMed id 17997974)1, 2 Bullock A.N.... Knapp S. (Structure 2007)
    4. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. (PubMed id 15590694)1, 2 Kario E.... Yarden Y. (J. Biol. Chem. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
    7. Negative regulation of cytokine signaling: STAT-induced STAT inhibitor. (PubMed id 10500304)1, 3 Naka T....Kishimoto T. (Trends Biochem. Sci. 1999)
    8. Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer. (PubMed id 20433750)1, 9 Sasi W....Mokbel K. (BMC Cancer 2010)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5. (PubMed id 22423360)1 Feng Z.P....Norton R.S. (Proteins 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 122809 HGNC: 19392 AceView: SOCS4 Ensembl:ENSG00000180008 euGenes: HUgn122809
    ECgene: SOCS4 Kegg: 122809 H-InvDB: SOCS4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOCS4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOCS4 gene:
    Search GeneIP for patents involving SOCS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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