Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOCS4 Gene

protein-coding   GIFtS: 60
GCID: GC14P055493

Suppressor Of Cytokine Signaling 4

(Previous name: suppressor of cytokine signaling 7)
(Previous symbol: SOCS7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppressor Of Cytokine Signaling 41 2     SH2 Domain Containing SOCS Box Protein2
Suppressor Of Cytokine Signaling 71 2 3     CIS45
SOCS71 2 3     SSI45
SOCS-42 3     STAT45
SOCS-72 3     

External Ids:    HGNC: 193921   Entrez Gene: 1228092   Ensembl: ENSG000001800087   OMIM: 6051185   UniProtKB: Q8WXH53   

Export aliases for SOCS4 gene to outside databases

Previous GC identifers: GC14P052833 GC18P068015 GC18P067741 GC18P066105 GC14P053484 GC14P054563 GC14P035656


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOCS4 Gene:
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the
suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS
family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively
spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for SOCS4 Gene: 
SOCS4 (suppressor of cytokine signaling 4) is a protein-coding gene. Diseases associated with SOCS4 include meningioma, and influenza, and among its related super-pathways are Type II diabetes mellitus and Prolactin Signaling. An important paralog of this gene is SOCS3.

UniProtKB/Swiss-Prot: SOCS4_HUMAN, Q8WXH5
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOCS4 gene promoter:
         AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   CREB   AREB6   STAT3   SEF-1 (1)   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOCS4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOCS4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOCS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.2   HGNC cytogenetic band: 14q22.1

SOCS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P055493:  view genomic region     (about GC identifiers)

Start:
55,493,844 bp from pter      End:
55,516,207 bp from pter
Size:
22,364 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SOCS4_HUMAN, Q8WXH5 (See protein sequence)
Recommended Name: Suppressor of cytokine signaling 4  
Size: 440 amino acids; 50623 Da
1 PDB 3D structure from and Proteopedia for SOCS4:
2IZV (3D)    

Explore the universe of human proteins at neXtProt for SOCS4: NX_Q8WXH5

Explore proteomics data for SOCS4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WXH5

  • SOCS4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SOCS4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_543143.1  NP_955453.1  

    ENSEMBL proteins: 
     ENSP00000378855   ENSP00000452522   ENSP00000341327  

    Human Recombinant Protein Products for SOCS4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SOCS4
    GenScript Custom Purified and Recombinant Proteins Services for SOCS4
    Novus Biologicals SOCS4 Protein
    Novus Biologicals SOCS4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOCS4 


    SOCS4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SOCS4 (SOCS-4)
    OriGene Antibodies for SOCS4
    OriGene Custom Antibody Services for SOCS4
    GenScript Custom Superior Antibodies Services for SOCS4
    Novus Biologicals SOCS4 Antibodies
    Abcam antibodies for SOCS4
    Cloud-Clone Corp. Antibodies for SOCS4 
    ThermoFisher Antibodies for SOCS4
    LSBio Antibodies in human, mouse, rat for SOCS4 

    Assay Products for SOCS4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SOCS4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SOCS4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOCS4 
    Cloud-Clone Corp. CLIAs for SOCS4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SOCS: Suppressors of cytokine signaling
    SH2D: SH2 domain containing

    3 InterPro protein domains:
     IPR001496 SOCS_C
     IPR000980 SH2
     IPR022252 SOCS

    Graphical View of Domain Structure for InterPro Entry Q8WXH5

    ProtoNet protein and cluster: Q8WXH5

    1 Blocks protein domain: IPB001496 SOCS protein

    UniProtKB/Swiss-Prot: SOCS4_HUMAN, Q8WXH5
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes (By similarity)
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SOCS box domain


    SOCS4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOCS4_HUMAN, Q8WXH5
    Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
    transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR
    Induction: Up-regulated by EGF

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SOCS4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SOCS4:
     Increased cell death HMECs cel  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SOCS4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SOCS4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOCS4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOCS4 

    10/172 SABiosciences Target genes for SOCS4 (see all 172):
    ACCSL ACSM2A ADIG ADORA1 ADRB3 ALB ALG1 APBB2 ARID3B ASPHD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SOCS4:
    hsa-mir-98 (MIRT005326)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOCS4
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate SOCS4 (see all 75):
    hsa-miR-607 hsa-miR-376b hsa-miR-4272 hsa-miR-1245 hsa-miR-374a hsa-miR-4273 hsa-miR-34c-5p hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SOCS4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOCS4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SOCS4
    Sirion Biotech Customized adenovirus for overexpression of SOCS4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SOCS4 (see all 13)
    OriGene ORF clones in mouse, rat for SOCS4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SOCS4 (NM_080867)
    Sino Biological Human cDNA Clone for SOCS4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS4
    Sirion Biotech Customized lentivirus for stable overexpression of SOCS4 
                         Customized lentivirus expression plasmids for stable overexpression of SOCS4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SOCS4
    Search LifeMap BioReagents cell lines for SOCS4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SOCS4 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Type II diabetes mellitus
    Type II diabetes mellitus0.38
    Type II diabetes mellitus0.35
    2ErbB4 Pathway
    Prolactin Signaling0.54
    IL-4 Pathway0.34
    Growth Hormone Signaling0.49
    3PEDF Induced Signaling
    IL-6 Pathway0.61
    STAT3 Pathway0.47
    4TGF-Beta Pathway
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Signaling events mediated by Stem cell factor receptor (c-Kit)
    Kit Receptor Signaling Pathway0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SOCS4 (see all 7)
        Growth Hormone Signaling
    STAT3 Pathway
    IL-4 Pathway
    JAK-STAT Pathway
    Prolactin Signaling

    2 BioSystems Pathways for SOCS4
        Type II diabetes mellitus
    Kit Receptor Signaling Pathway



    4         Kegg Pathways  (Kegg details for SOCS4):
        Jak-STAT signaling pathway
    Insulin signaling pathway
    Prolactin signaling pathway
    Type II diabetes mellitus

    UniProtKB/Swiss-Prot: SOCS4_HUMAN, Q8WXH5
    Pathway: Protein modification; protein ubiquitination


    SOCS4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SOCS4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for SOCS4 (Q8WXH52, 3 ENSP000003413274) via UniProtKB, MINT, STRING, and/or I2D (see all 58)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEB1Q153692, 3, ENSP000002848114MINT-2835855 I2D: score=1 STRING: ENSP00000284811
    JAK2O606743, ENSP000003710674I2D: score=1 STRING: ENSP00000371067
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    KITP107213I2D: score=1 
    TCEB2ENSP000002623064STRING: ENSP00000262306
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007175negative regulation of epidermal growth factor-activated receptor activity IDA15590694
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--
    GO:0040008regulation of growth IEA--

    SOCS4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOCS4

    Search CenterWatch for drugs/clinical trials and news about SOCS4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SOCS4 gene (2 alternative transcripts): 
    NM_080867.2  NM_199421.1  

    Unigene Cluster for SOCS4:

    Suppressor of cytokine signaling 4
    Hs.744302  [show with all ESTs]
    Unigene Representative Sequence: NM_199421
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395472(uc001xbo.3 uc001xbp.3) ENST00000555846 ENST00000553735
    ENST00000339298
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOCS4
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate SOCS4 (see all 75):
    hsa-miR-607 hsa-miR-376b hsa-miR-4272 hsa-miR-1245 hsa-miR-374a hsa-miR-4273 hsa-miR-34c-5p hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SOCS4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOCS4
    Clone
    Products:
         
    OriGene clones in human, mouse for SOCS4 (see all 13)
    OriGene ORF clones in mouse, rat for SOCS4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SOCS4 (NM_080867)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS4
    Sirion Biotech Customized lentivirus for stable overexpression of SOCS4 
                         Customized lentivirus expression plasmids for stable overexpression of SOCS4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SOCS4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SOCS4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOCS4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOCS4

    Additional mRNA sequence: 

    AF424815.1 AK056685.1 AK124083.1 AK126195.1 AK127299.1 BC060790.1 BX161418.1 BX648734.1 
    CR933659.1 

    7 DOTS entries:

    DT.101961928  DT.99974426  DT.91955278  DT.100751679  DT.212307  DT.91706531  DT.100746814 

    24/121 AceView cDNA sequences (see all 121):

    BX491558 BQ446934 BU951909 BU686061 AV660502 BX506489 BI492088 AI653056 
    BC060790 BU181205 BU952166 BM479640 AI472184 AI082443 BU741261 BX648734 
    NM_199421 AI348677 BU786158 CB045775 BX161418 BG054997 AF424815 AI000715 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SOCS4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for SOCS4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOCS4 expression in normal human tissues (normalized intensities)      SOCS4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTCGAATA
    SOCS4 Expression
    About this image


    SOCS4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer

    See SOCS4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SOCS4

    SOURCE GeneReport for Unigene cluster: Hs.744302
        SABiosciences Expression via Pathway-Focused PCR Arrays including SOCS4: 
              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SOCS4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SOCS4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOCS4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOCS4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SOCS4 gene from 6/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Socs41 , 5 suppressor of cytokine signaling 41, 5 86.31(n)1
    87.39(a)1
      14 (24.60 cM)5
    672961  NM_080843.21  NP_543119.21 
     472769315 
    chicken
    (Gallus gallus)
    Aves SOCS41 suppressor of cytokine signaling 4 74.87(n)
    79.54(a)
      423557  NM_001199108.1  NP_001186037.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOCS46
    Uncharacterized protein
    79(a)
    1 ↔ 1
    GL343325.1(84216-85526)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX745222.12   -- 74.95(n)    BX745222.1 
    zebrafish
    (Danio rerio)
    Actinopterygii socs46
    socs96
    suppressor of cytokine signaling 9
    42(a)
    39(a)
    1 ↔ 1
    possible ortholog
    17(15038510-15042143)
    15(46568718-46570669)
    fruit fly
    (Drosophila melanogaster)
    Insecta Socs36E3 JAK-STAT cascade 66(a)   36D3   --


    ENSEMBL Gene Tree for SOCS4 (if available)
    TreeFam Gene Tree for SOCS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOCS4 gene
    SOCS32  SOCS52  SOCS72  SOCS12  SOCS62  CISH2  SOCS22  
    2 SIMAP similar genes for SOCS4 using alignment to 1 protein entry:     SOCS4_HUMAN:
    DKFZp686J1568    SOCS5

    SOCS4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/398 SNPs in SOCS4 are shown (see all 398)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924215901,2
    --55495862(+) TTCAGA/TGAGTT 2 -- int10--------
    rs765185141,2
    C,F--55495866(+) GTGAGT/ATTATG 2 -- int11Minor allele frequency- A:0.07NA 120
    rs797419501,2
    --55495918(+) ATGATA/GGTGCA 2 -- int10--------
    rs1853863861,2
    --55495969(+) TAGTTA/GGTTAA 2 -- int10--------
    rs1883508531,2
    --55496087(+) TGTGGA/GTGGCT 2 -- int10--------
    rs12126411,2
    C,F,A,H--55496131(-) CAATTG/CAATCT 2 -- int115Minor allele frequency- C:0.29MN NS EA NA WA CSA 880
    rs1169059581,2
    C,F--55496248(+) TGCCAT/CTCTAC 2 -- int11Minor allele frequency- C:0.01NA 120
    rs1166520511,2
    F--55496256(+) TACCAA/GTGATG 2 -- int11Minor allele frequency- G:0.03WA 118
    rs1929373621,2
    --55496365(+) AAATAG/TGTACT 2 -- int10--------
    rs1382492151,2
    --55496654(+) CCAGTA/GTTTGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for SOCS4 (55493844 - 55516207 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SOCS4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv84529CNV Loss16902084

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SOCS4
    DNA2.0 Custom Variant and Variant Library Synthesis for SOCS4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605118    OMIM disorders: --

    6 diseases for SOCS4:    About MalaCards
    meningioma    influenza    diabetes mellitus    gastric cancer
    breast cancer    leukemia


    SOCS4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SOCS4
    Human Genome Epidemiology (HuGE) Navigator: SOCS4 (10 documents)

    Export disorders for SOCS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOCS4 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SOCS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    2. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    3. Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. (PubMed id 17997974)1, 2 Bullock A.N....Knapp S. (2007)
    4. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. (PubMed id 15590694)1, 2 Kario E....Yarden Y. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (2002)
    7. Negative regulation of cytokine signaling: STAT-induc ed STAT inhibitor. (PubMed id 10500304)1, 3 Naka T....Kishimoto T. (1999)
    8. Higher expression levels of SOCS 1,3,4,7 are associat ed with earlier tumour stage and better clinical outcome in human breast cancer . (PubMed id 20433750)1, 9 Sasi W....Mokbel K. (2010)
    9. The N-terminal domains of SOCS proteins: a conserved r egion in the disordered N-termini of SOCS4 and 5. (PubMed id 22423360)1 Feng Z.P....Norton R.S. (2012)
    10. Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis. (PubMed id 22127425)1 Kobayashi D....Nakao A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 122809 HGNC: 19392 AceView: SOCS4 Ensembl:ENSG00000180008 euGenes: HUgn122809
    ECgene: SOCS4 Kegg: 122809 H-InvDB: SOCS4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOCS4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SOCS4 gene:
    Search GeneIP for patents involving SOCS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SOCS4 (SOCS-4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SOCS4   OriGene RNAi products in human, mouse, rat for SOCS4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SOCS4  
     OriGene qSTAR qPCR primer pairs in human, mouse for SOCS4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SOCS4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SOCS4   OriGene Custom Protein Services for SOCS4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SOCS4
     QIAGEN SeqTarget long-range PCR primers for resequencing SOCS4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOCS4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOCS4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOCS4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOCS4
     GenScript Custom Purified and Recombinant Proteins Services for SOCS4 GenScript cDNA clones with any tag delivered in your preferred vector for SOCS4
     GenScript Custom Assay Services for SOCS4 GenScript Custom Superior Antibodies Services for SOCS4
     GenScript Custom overexpressing Cell Line Services for SOCS4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SOCS4 promoter
     Search Chromatin IP Primers for SOCS4
     RT2 qPCR Primer Assay in human, mouse, rat SOCS4
     Search GNC Networks for SOCS4
     SABiosciences PCR Arrays including human, mouse, rat SOCS4
     Search Tocris compounds for SOCS4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SOCS4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SOCS4 antibodies
     SOCS4 proteins
     SOCS4 lysates
     Antibodies for SOCS4
     See all of Abcam's Antibodies, Kits and Proteins for SOCS4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SOCS4
     Antibodies for SOCS4
     ELISAs for SOCS4
     CLIAs for SOCS4
     Search LifeMap BioReagents cell lines for SOCS4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SOCS4
     SwitchGear Promoter luciferase reporter plasmids for SOCS4
     ThermoFisher Antibodies for SOCS4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SOCS4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SOCS4
    Customized:
     lentivirus for stable overexpression of SOCS4
     lentivirus expression plasmids for stable overexpression of SOCS4
     adenovirus for overexpression of SOCS4
     LSBio Antibodies in human, mouse, rat for SOCS4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SOCS4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4