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Aliases for SOCS4 Gene

Aliases for SOCS4 Gene

  • Suppressor Of Cytokine Signaling 4 2 3
  • Suppressor Of Cytokine Signaling 7 2 3 4
  • SOCS-7 3 4
  • SOCS-4 3 4
  • SOCS7 3 4
  • SH2 Domain Containing SOCS Box Protein 3
  • STAT4 6
  • SSI4 6
  • CIS4 6

External Ids for SOCS4 Gene

Previous HGNC Symbols for SOCS4 Gene

  • SOCS7

Previous GeneCards Identifiers for SOCS4 Gene

  • GC14P052833
  • GC18P068015
  • GC18P067741
  • GC18P066105
  • GC14P053484
  • GC14P054563
  • GC14P055493
  • GC14P035656

Summaries for SOCS4 Gene

Entrez Gene Summary for SOCS4 Gene

  • The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOCS4 Gene

SOCS4 (Suppressor Of Cytokine Signaling 4) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and Akt Signaling. An important paralog of this gene is SOCS2.

UniProtKB/Swiss-Prot for SOCS4 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS4 Gene

Genomics for SOCS4 Gene

Regulatory Elements for SOCS4 Gene

Genomic Location for SOCS4 Gene

Start:
55,027,126 bp from pter
End:
55,049,489 bp from pter
Size:
22,364 bases
Orientation:
Plus strand

Genomic View for SOCS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOCS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS4 Gene

Proteins for SOCS4 Gene

  • Protein details for SOCS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXH5-SOCS4_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 4
    Protein Accession:
    Q8WXH5
    Secondary Accessions:

    Protein attributes for SOCS4 Gene

    Size:
    440 amino acids
    Molecular mass:
    50623 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SOCS4 Gene

neXtProt entry for SOCS4 Gene

Proteomics data for SOCS4 Gene at MOPED

Post-translational modifications for SOCS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOCS4 Gene

No data available for DME Specific Peptides for SOCS4 Gene

Domains for SOCS4 Gene

Gene Families for SOCS4 Gene

HGNC:
  • SH2D :SH2 domain containing
  • SOCS :Suppressors of cytokine signaling

Protein Domains for SOCS4 Gene

Suggested Antigen Peptide Sequences for SOCS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXH5

UniProtKB/Swiss-Prot:

SOCS4_HUMAN :
  • Q8WXH5
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 SH2 domain.
  • Contains 1 SOCS box domain.
genes like me logo Genes that share domains with SOCS4: view

Function for SOCS4 Gene

Molecular function for SOCS4 Gene

UniProtKB/Swiss-Prot Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
UniProtKB/Swiss-Prot Induction: Up-regulated by EGF.

Gene Ontology (GO) - Molecular Function for SOCS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
genes like me logo Genes that share ontologies with SOCS4: view

Phenotypes for SOCS4 Gene

genes like me logo Genes that share phenotypes with SOCS4: view

Animal Model Products

CRISPR Products

Transcription Factor Targeting for SOCS4 Gene

Selected GeneGlobe predicted Target genes for SOCS4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOCS4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models and HOMER Transcription for SOCS4 Gene

Localization for SOCS4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOCS4 Gene COMPARTMENTS Subcellular localization image for SOCS4 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SOCS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SOCS4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SOCS4 Gene

Pathways for SOCS4 Gene

genes like me logo Genes that share pathways with SOCS4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q8WXH5-SOCS4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SOCS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity IDA 15590694
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with SOCS4: view

Transcripts for SOCS4 Gene

Unigene Clusters for SOCS4 Gene

Suppressor of cytokine signaling 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOCS4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SOCS4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for SOCS4 Gene

GeneLoc Exon Structure for
SOCS4
ECgene alternative splicing isoforms for
SOCS4

Expression for SOCS4 Gene

mRNA expression in normal human tissues for SOCS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SOCS4 Gene Hs.744302

genes like me logo Genes that share expressions with SOCS4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for SOCS4 Gene

Orthologs for SOCS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOCS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOCS4 35
  • 99.77 (n)
  • 99.77 (a)
SOCS4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SOCS4 35
  • 92.41 (n)
  • 93.39 (a)
SOCS4 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOCS4 35
  • 94.02 (n)
  • 93.41 (a)
SOCS4 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Socs4 35
  • 86.31 (n)
  • 87.39 (a)
Socs4 16
Socs4 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Socs4 35
  • 84.33 (n)
  • 85.55 (a)
chicken
(Gallus gallus)
Aves SOCS4 35
  • 74.87 (n)
  • 79.54 (a)
SOCS4 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOCS4 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia socs4 35
  • 70.53 (n)
  • 73.55 (a)
zebrafish
(Danio rerio)
Actinopterygii socs4 36
  • 49 (a)
OneToOne
socs9 35
  • 50.2 (n)
  • 50.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta Socs36E 36
  • 26 (a)
OneToMany
Socs36E 37
  • 66 (a)
Species with no ortholog for SOCS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOCS4 Gene

ENSEMBL:
Gene Tree for SOCS4 (if available)
TreeFam:
Gene Tree for SOCS4 (if available)

Paralogs for SOCS4 Gene

Paralogs for SOCS4 Gene

Selected SIMAP similar genes for SOCS4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOCS4: view

Variants for SOCS4 Gene

Sequence variations from dbSNP and Humsavar for SOCS4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs14854 -- 55,049,382(+) CTTTT(A/T)TTTCT utr-variant-3-prime
rs1187873 -- 55,033,533(-) gtaac(A/G)tctta intron-variant
rs1187874 -- 55,031,385(-) TGCCA(C/T)AAATC intron-variant
rs1187875 -- 55,030,179(-) CTCTA(C/G)ACTTT intron-variant
rs1212641 -- 55,029,413(-) CAATT(C/G)AATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SOCS4 Gene

Variant ID Type Subtype PubMed ID
nsv84529 CNV Loss 16902084

Relevant External Links for SOCS4 Gene

HapMap Linkage Disequilibrium report
SOCS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS4 Gene

Disorders for SOCS4 Gene

Relevant External Links for SOCS4

Genetic Association Database (GAD)
SOCS4
Human Genome Epidemiology (HuGE) Navigator
SOCS4
genes like me logo Genes that share disorders with SOCS4: view

No data available for UniProtKB/Swiss-Prot for SOCS4 Gene

Publications for SOCS4 Gene

  1. Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer. (PMID: 20433750) Sasi W. … Mokbel K. (BMC Cancer 2010) 3 23
  2. Negative regulation of cytokine signaling: STAT-induced STAT inhibitor. (PMID: 10500304) Naka T. … Kishimoto T. (Trends Biochem. Sci. 1999) 2 3
  3. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. (PMID: 15590694) Kario E. … Yarden Y. (J. Biol. Chem. 2005) 3 4

Products for SOCS4 Gene

Sources for SOCS4 Gene

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