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Aliases for SOCS3 Gene

Aliases for SOCS3 Gene

  • Suppressor Of Cytokine Signaling 3 2 3
  • CIS3 3 4 6
  • SSI3 3 4 6
  • Cytokine-Inducible SH2 Protein 3 3 4
  • STAT-Induced STAT Inhibitor 3 3 4
  • SOCS-3 3 4
  • SSI-3 3 4
  • ATOD4 3
  • Cish3 3
  • CIS-3 4

External Ids for SOCS3 Gene

Previous GeneCards Identifiers for SOCS3 Gene

  • GC17M079741
  • GC17M076815
  • GC17M076951
  • GC17M076949
  • GC17M073864
  • GC17M076352
  • GC17M071775

Summaries for SOCS3 Gene

Entrez Gene Summary for SOCS3 Gene

  • This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOCS3 Gene

SOCS3 (Suppressor Of Cytokine Signaling 3) is a Protein Coding gene. Diseases associated with SOCS3 include primary polycythemia and allergic conjunctivitis. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS2.

UniProtKB/Swiss-Prot for SOCS3 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Gene Wiki entry for SOCS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS3 Gene

Genomics for SOCS3 Gene

Regulatory Elements for SOCS3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SOCS3 Gene

Start:
78,356,777 bp from pter
End:
78,360,079 bp from pter
Size:
3,303 bases
Orientation:
Minus strand

Genomic View for SOCS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOCS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS3 Gene

Proteins for SOCS3 Gene

  • Protein details for SOCS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14543-SOCS3_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 3
    Protein Accession:
    O14543
    Secondary Accessions:
    • O14509

    Protein attributes for SOCS3 Gene

    Size:
    225 amino acids
    Molecular mass:
    24770 Da
    Quaternary structure:
    • Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilizes SOCS3 protein. Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with CUL2. Interacts with FGFR3. Interacts with INSR (By similarity). Interacts with BCL10; this interaction may interfere with BCL10-binding with PELI2 (By similarity).

neXtProt entry for SOCS3 Gene

Proteomics data for SOCS3 Gene at MOPED

Post-translational modifications for SOCS3 Gene

  • Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOCS3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SOCS3 (SOCS3)

No data available for DME Specific Peptides for SOCS3 Gene

Domains for SOCS3 Gene

Gene Families for SOCS3 Gene

HGNC:
  • SH2D :SH2 domain containing
  • SOCS :Suppressors of cytokine signaling

Protein Domains for SOCS3 Gene

Graphical View of Domain Structure for InterPro Entry

O14543

UniProtKB/Swiss-Prot:

SOCS3_HUMAN :
  • O14543
Domain:
  • The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 SH2 domain.
  • Contains 1 SOCS box domain.
genes like me logo Genes that share domains with SOCS3: view

Function for SOCS3 Gene

Molecular function for SOCS3 Gene

UniProtKB/Swiss-Prot Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Gene Ontology (GO) - Molecular Function for SOCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 9266833
GO:0005515 protein binding IPI 19027008
genes like me logo Genes that share ontologies with SOCS3: view
genes like me logo Genes that share phenotypes with SOCS3: view

Animal Models for SOCS3 Gene

MGI Knock Outs for SOCS3:

Animal Model Products

CRISPR Products

miRNA for SOCS3 Gene

miRTarBase miRNAs that target SOCS3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOCS3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SOCS3 Gene

Localization for SOCS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOCS3 Gene COMPARTMENTS Subcellular localization image for SOCS3 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SOCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SOCS3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SOCS3 Gene

Pathways for SOCS3 Gene

genes like me logo Genes that share pathways with SOCS3: view

PCR Array Products

UniProtKB/Swiss-Prot O14543-SOCS3_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SOCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation --
GO:0006469 negative regulation of protein kinase activity TAS 9266833
GO:0007259 JAK-STAT cascade TAS 9266833
GO:0009968 negative regulation of signal transduction --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with SOCS3: view

Compounds for SOCS3 Gene

(26) Novoseek inferred chemical compound relationships for SOCS3 Gene

Compound -log(P) Hits PubMed IDs
gp 130 75.9 31
tyrosine 60.2 70
ifn-alpha 52.1 4
5-aza-2deoxycytidine 51.1 8
ribavirin 33.7 1
genes like me logo Genes that share compounds with SOCS3: view

Transcripts for SOCS3 Gene

mRNA/cDNA for SOCS3 Gene

Unigene Clusters for SOCS3 Gene

Suppressor of cytokine signaling 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOCS3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1: - -
SP2:

Relevant External Links for SOCS3 Gene

GeneLoc Exon Structure for
SOCS3
ECgene alternative splicing isoforms for
SOCS3

Expression for SOCS3 Gene

mRNA expression in normal human tissues for SOCS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOCS3 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (8.2), Fallopian Tube (6.3), and Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SOCS3 Gene

SOURCE GeneReport for Unigene cluster for SOCS3 Gene Hs.527973

mRNA Expression by UniProt/SwissProt for SOCS3 Gene

O14543-SOCS3_HUMAN
Tissue specificity: Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus
genes like me logo Genes that share expressions with SOCS3: view

In Situ Assay Products

Orthologs for SOCS3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SOCS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOCS3 35
  • 100 (n)
  • 100 (a)
SOCS3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SOCS3 35
  • 92.3 (n)
  • 95.11 (a)
SOCS3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOCS3 35
  • 94.67 (n)
  • 96.89 (a)
SOCS3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Socs3 35
  • 90.81 (n)
  • 96.89 (a)
Socs3 16
Socs3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SOCS3 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOCS3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Socs3 35
  • 89.93 (n)
  • 95.56 (a)
chicken
(Gallus gallus)
Aves SOCS3 35
  • 84.69 (n)
  • 89.47 (a)
SOCS3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOCS3 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia socs3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia socs3 35
  • 68.51 (n)
  • 74.37 (a)
zebrafish
(Danio rerio)
Actinopterygii socs3a 36
  • 61 (a)
OneToMany
socs3b 35
  • 67.8 (n)
  • 66.83 (a)
socs3b 36
  • 62 (a)
OneToMany
wufj09e12 35
Species with no ortholog for SOCS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOCS3 Gene

ENSEMBL:
Gene Tree for SOCS3 (if available)
TreeFam:
Gene Tree for SOCS3 (if available)

Paralogs for SOCS3 Gene

Paralogs for SOCS3 Gene

genes like me logo Genes that share paralogs with SOCS3: view

Variants for SOCS3 Gene

Sequence variations from dbSNP and Humsavar for SOCS3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2280148 -- 78,358,299(-) GGGAA(A/C)GAGGG utr-variant-3-prime
rs4969168 -- 78,357,712(+) CATCC(A/G)TCCCC utr-variant-3-prime
rs4969169 -- 78,357,829(+) TGGGG(C/T)ACCAG utr-variant-3-prime
rs41522945 -- 78,358,045(+) AGTTC(C/G/T)GTTGG utr-variant-3-prime
rs70937027 -- 78,357,214(-) TGCTC(A/C)CGCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SOCS3 Gene

Variant ID Type Subtype PubMed ID
nsv908880 CNV Loss 21882294
nsv908881 CNV Loss 21882294
nsv908882 CNV Loss 21882294
nsv833555 CNV Loss 17160897

Relevant External Links for SOCS3 Gene

HapMap Linkage Disequilibrium report
SOCS3
Human Gene Mutation Database (HGMD)
SOCS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS3 Gene

Disorders for SOCS3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (6) Diseases for SOCS3 Gene including...

Search for SOCS3 Gene in MalaCards »

UniProtKB/Swiss-Prot

SOCS3_HUMAN
  • Note=There is some evidence that SOCS3 may be a susceptibility gene for atopic dermatitis linked to 17q25. SOCS3 messenger RNA is significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls. Furthermore, a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene has been found in two independent groups of patients.

(2) University of Copenhagen DISEASES for SOCS3 Gene

(53) Novoseek inferred disease relationships for SOCS3 Gene

Disease -log(P) Hits PubMed IDs
insulin resistance 49.9 19
leukemia 43 11
polycythemia vera 42.6 4
inflammation 40.5 22
obesity 39.5 14

Relevant External Links for SOCS3

Genetic Association Database (GAD)
SOCS3
Human Genome Epidemiology (HuGE) Navigator
SOCS3
genes like me logo Genes that share disorders with SOCS3: view

Publications for SOCS3 Gene

  1. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PMID: 9266833) Minamoto S. … Kishimoto T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. (PMID: 10421843) Sasaki A. … Yoshimura A. (Genes Cells 1999) 3 4 23
  3. Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor. (PMID: 11071852) Dey B.R. … Nissley P. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  4. A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. (PMID: 12027890) Hoertner M. … Haan S. (Eur. J. Biochem. 2002) 3 4 23
  5. Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity. (PMID: 15249995) Gylvin T. … Pociot F. (Diabetologia 2004) 3 23 48

Products for SOCS3 Gene

Sources for SOCS3 Gene

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