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SOCS3 Gene

protein-coding   GIFtS: 66
GCID: GC17M076352

Suppressor Of Cytokine Signaling 3

  See SOCS3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Cytokine Signaling 31 2     SSI-32 3
CIS32 3 5     STAT-Induced STAT Inhibitor 32 3
SSI32 3 5     ATOD42
Cytokine-Inducible SH2 Protein 32 3     Cish32
SOCS-32 3     CIS-33

External Ids:    HGNC: 193911   Entrez Gene: 90212   Ensembl: ENSG000001845577   OMIM: 6041765   UniProtKB: O145433   

Export aliases for SOCS3 gene to outside databases

Previous GC identifers: GC17M079741 GC17M076815 GC17M076951 GC17M076949 GC17M073864 GC17M071775


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOCS3 Gene:
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine
signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.
The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The
protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the
mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver
hematopoiesis, and placental development. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOCS3 Gene:
SOCS3 (suppressor of cytokine signaling 3) is a protein-coding gene. Diseases associated with SOCS3 include primary polycythemia, and allergic conjunctivitis. GO annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS4.

UniProtKB/Swiss-Prot: SOCS3_HUMAN, O14543
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway.
Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF,
erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity.
Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper
type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a
SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the
ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By
similarity)

Gene Wiki entry for SOCS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOCS3 gene promoter:
         STAT5B   GATA-3   Pax-5   NRSF form 1   AP-4   NRSF form 2   PPAR-gamma1   c-Rel   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SOCS3 promoter sequence
   Search Chromatin IP Primers for SOCS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOCS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

SOCS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M076352:  view genomic region     (about GC identifiers)

Start:
76,352,859 bp from pter      End:
76,356,158 bp from pter
Size:
3,300 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SOCS3_HUMAN, O14543 (See protein sequence)
Recommended Name: Suppressor of cytokine signaling 3  
Size: 225 amino acids; 24770 Da
Subunit: Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1
receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a
phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the
leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilizes SOCS3 protein. Component of the
probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and
SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with CUL2. Interacts with FGFR3. Interacts with INSR
(By similarity). Interacts with BCL10; this interaction may interfere with BCL10-binding with PELI2 (By
similarity)
Secondary accessions: O14509

Explore the universe of human proteins at neXtProt for SOCS3: NX_O14543

Explore proteomics data for SOCS3 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOCS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003946.3  
    ENSEMBL proteins: 
     ENSP00000330341   ENSP00000464727  
    Reactome Protein details: O14543

    SOCS3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for SOCS3
    OriGene MassSpec for SOCS3
    OriGene Custom Protein Services for SOCS3
    GenScript Custom Purified and Recombinant Proteins Services for SOCS3
    Novus Biologicals SOCS3 Protein
    Novus Biologicals SOCS3 Lysates
    Sino Biological Recombinant Protein for SOCS3
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOCS3

     
    Search eBioscience for Proteins for SOCS3 

     
    antibodies-online proteins for SOCS3 (13 products) 

     
    antibodies-online peptides for SOCS3

    SOCS3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SOCS3
    R&D Systems Antibodies for SOCS3 (SOCS-3)
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    Novus Biologicals SOCS3 Antibodies
    Abcam antibodies for SOCS3
    Cloud-Clone Corp. Antibodies for SOCS3
    ThermoFisher Antibodies for SOCS3
    antibodies-online antibodies for SOCS3 (128 products) 

    SOCS3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SOCS3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOCS3
    Cloud-Clone Corp. CLIAs for SOCS3
    Search eBioscience for ELISAs for SOCS3 
    antibodies-online kits for SOCS3 (37 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SOCS: Suppressors of cytokine signaling
    SH2D: SH2 domain containing

    4 InterPro protein domains:
     IPR001496 SOCS_C
     IPR000980 SH2
     IPR028413 SOCS
     IPR028414 SOCS3

    Graphical View of Domain Structure for InterPro Entry O14543

    ProtoNet protein and cluster: O14543

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001496 SOCS protein


    UniProtKB/Swiss-Prot: SOCS3_HUMAN, O14543
    Domain: The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR
    domain is necessary for signal and kinase inhibition
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes (By similarity)
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SOCS box domain


    Find genes that share domains with SOCS3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOCS3_HUMAN, O14543
    Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
    transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway.
    Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF,
    erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity.
    Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper
    type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a
    SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the
    ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860protein kinase inhibitor activity TAS9266833
    GO:0005515protein binding IPI19027008
         
    Find genes that share ontologies with SOCS3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SOCS3:
     Decreased viability with pacli  Wnt reporter downregulated 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Socs3) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  normal  respiratory system 

    Find genes that share phenotypes with SOCS3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SOCS3: Socs3tm1Jni Socs3tm2.1Wsa

       genOway: Develop your customized and physiologically relevant rodent model for SOCS3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SOCS3:
    hsa-mir-203a (MIRT005062), hsa-mir-30c-5p (MIRT007129)

    Block miRNA regulation of human, mouse, rat SOCS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOCS3 (see all 46):
    hsa-miR-520f hsa-miR-30d hsa-miR-759 hsa-miR-218 hsa-miR-508-3p hsa-miR-1304 hsa-miR-30a hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidSOCS3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOCS3
    Predesigned siRNA for gene silencing in human, mouse, rat SOCS3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SOCS3

    Clone
    Products:
         
    OriGene clones in human, mouse for SOCS3 (see all 7)
    OriGene ORF clones in mouse, rat for SOCS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOCS3 (NM_003955)
    Sino Biological Human cDNA Clone for SOCS3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SOCS3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SOCS3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SOCS3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOCS3 About   (see all 47)  
    See pathways by source

    SuperPathContained pathways About
    1Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33
    2IL-9 Signaling Pathways
    IL-9 Signaling Pathway0.42
    IL-9 Pathway0.36
    Immune response IL 9 signaling pathway0.42
    3Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    4Immune response IL 23 signaling pathway
    Immune response IL 23 signaling pathway0.41
    IL23-mediated signaling events0.38
    Immune response IL 10 signaling pathway0.38
    5IL2-mediated signaling events
    IL-2 Signaling pathway0.49
    IL2-mediated signaling events0.49


    Find genes that share SuperPaths with SOCS3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SOCS3 (see all 10)
        IL-9 Pathway
    STAT3 Pathway
    IL-10 Pathway
    IL-4 Pathway
    JAK-STAT Pathway

    2 Cell Signaling Technology (CST) Pathways for SOCS3
        Tyrosine Kinases / Adaptors
    Jak/Stat Pathway

    Selected GeneGo (Thomson Reuters) Pathways for SOCS3 (see all 14)
        Immune response IL-6 signaling pathway
    Development Leptin signaling via JAK/STAT and MAPK cascades
    Development CNTF receptor signaling
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response IL-9 signaling pathway

    Selected BioSystems Pathways for SOCS3 (see all 21)
        EGFR1 Signaling Pathway
    Adipogenesis
    Insulin Signaling
    Type II interferon signaling (IFNG)
    Oncostatin M Signaling Pathway


    Selected Reactome Pathways for SOCS3 (see all 7)
        Regulation of IFNA signaling
    Interleukin-6 signaling
    Interferon gamma signaling
    Regulation of IFNG signaling
    Antigen processing: Ubiquitination & Proteasome degradation


    Selected Kegg Pathways  (Kegg details for SOCS3) (see all 12):
        Ubiquitin mediated proteolysis
    Osteoclast differentiation
    Jak-STAT signaling pathway
    TNF signaling pathway
    Insulin signaling pathway

    UniProtKB/Swiss-Prot: SOCS3_HUMAN, O14543
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOCS3 (see all 14): 

              Nephrotoxicity in human mouse rat
              Prostate Cancer in human mouse rat
              Liver Cancer in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SOCS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SOCS3 (O145431, 2, 3 ENSP000003303414) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1SQ66K741, 2, 3, ENSP000003253134EBI-714146,EBI-2133734 MINT-6796936 MINT-6796894 MINT-6796909 MINT-6796957 MINT-6796979 MINT-6796875 I2D: score=2 STRING: ENSP00000325313
    MAPK11Q157592, 3, ENSP000003336854MINT-8260548 I2D: score=2 STRING: ENSP00000333685
    PIN1Q135262, 3MINT-63063 I2D: score=5 
    MAPK6Q166592, 3MINT-8262022 I2D: score=2 
    PDPK1O155302, 3MINT-8265621 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001932regulation of protein phosphorylation ----
    GO:0006469negative regulation of protein kinase activity TAS9266833
    GO:0007259JAK-STAT cascade TAS9266833
    GO:0009968negative regulation of signal transduction ----
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with SOCS3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOCS3

    Selected Novoseek inferred chemical compound relationships for SOCS3 gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 75.9 39 10829066 (6), 12403768 (4), 18986700 (3), 12593670 (3) (see all 16)
    tyrosine 60.2 94 10373548 (5), 12783885 (4), 10585430 (3), 10421843 (3) (see all 49)
    ifn-alpha 52.1 8 15618960 (2), 18616672 (1), 11340296 (1)
    5-aza-2'deoxycytidine 51.1 12 18507841 (2), 17376806 (1), 16007195 (1), 19929568 (1) (see all 7)
    ribavirin 33.7 1 19624774 (1)
    glucose 11.1 18 19435854 (3), 20067961 (2), 17194639 (2), 15331532 (2) (see all 10)
    con a 8.25 1 16474852 (1)
    phosphatidylinositol 6.93 1 12396724 (1)
    acth 4.04 6 10098488 (2), 11268394 (1), 12639901 (1), 15249728 (1)
    cocaine 2.54 2 18638026 (1), 19726709 (1)



    Find genes that share compounds with SOCS3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOCS3 gene: 
    NM_003955.4  

    Unigene Cluster for SOCS3:

    Suppressor of cytokine signaling 3
    Hs.527973  [show with all ESTs]
    Unigene Representative Sequence: NM_003955
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330871(uc002jvl.2) ENST00000587578
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SOCS3 (see all 46):
    hsa-miR-520f hsa-miR-30d hsa-miR-759 hsa-miR-218 hsa-miR-508-3p hsa-miR-1304 hsa-miR-30a hsa-miR-383
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SOCS3 (NM_003955)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS3
    Primer
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    OriGene qPCR primer pairs and template standards for SOCS3
    OriGene qSTAR qPCR primer pairs in human, mouse for SOCS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOCS3
      QuantiTect SYBR Green Assays in human, mouse, rat SOCS3
      QuantiFast Probe-based Assays in human, mouse, rat SOCS3

    Additional mRNA sequence: 

    AB004904.1 AB006967.1 AF159854.1 AK309756.1 AK314212.1 BC060858.1 BT019544.1 CR536497.1 
    CR541694.1 

    4 DOTS entries:

    DT.412699  DT.92419300  DT.100791006  DT.91746741 

    Selected AceView cDNA sequences (see all 124):

    BF514189 CR536497 CD368293 BG236059 CD673321 AW055348 BQ003407 AI968957 
    CD672917 CA447987 AW664221 BQ016286 CA423840 AI678436 NM_003955 AI830013 
    BG752935 BQ004289 CR602820 CA848307 AI924575 CR541694 BQ018132 BQ687823 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SOCS3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c
    SP1:        -     -               
    SP2:                              


    ECgene alternative splicing isoforms for SOCS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SOCS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCCCAGCT
    SOCS3 Expression
    About this image


    SOCS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Mature Granulosa Cells Antral Follicle
             Secondary follicles
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    SOCS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOCS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.527973

    UniProtKB/Swiss-Prot: SOCS3_HUMAN, O14543
    Tissue specificity: Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood
    leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOCS3 (see all 14): 
              Nephrotoxicity in human mouse rat
              Prostate Cancer in human mouse rat
              Liver Cancer in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SOCS3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Socs31 , 5 suppressor of cytokine signaling 31, 5 90.81(n)1
    96.89(a)1
      11 (82.96 cM)5
    127021  NM_007707.31  NP_031733.11 
     1179660795 
    chicken
    (Gallus gallus)
    Aves SOCS31 suppressor of cytokine signaling 3 84.69(n)
    89.47(a)
      395299  NM_204600.1  NP_989931.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOCS36
    suppressor of cytokine signaling 3
    89(a)
    1 ↔ 1
    2(102112975-102118015)
    African clawed frog
    (Xenopus laevis)
    Amphibia socs3-prov2 suppressor of cytokine signaling 3 73.43(n)    BC054214.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj09e122 wufj09e12 78.33(n)   335409  BC049326.1 


    ENSEMBL Gene Tree for SOCS3 (if available)
    TreeFam Gene Tree for SOCS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOCS3 gene
    SOCS42  SOCS52  SOCS72  SOCS12  SOCS62  CISH2  SOCS22  

    Find genes that share paralogs with SOCS3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOCS3 (see all 100)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1110338501,2
    Cuntested177441344(-) AGGAAC/TCGGGG 1 -- us2k10--------
    rs1872898321,2
    --77437506(+) AGGGGA/GTGGGG 1 -- ds50010--------
    rs1921755471,2
    --77437548(+) CACCCC/TTCCCC 1 -- ds50010--------
    rs773446061,2
    C,F--77437554(+) TCCCCC/ACACTT 1 -- ds50011Minor allele frequency- A:0.11WA 118
    rs1432866731,2
    --77437605(+) GGACCC/TCATGT 1 -- ds50010--------
    rs1838434861,2
    --77437613(+) TGTCTC/GGGCTT 1 -- ds50010--------
    rs768489191,2
    C,F--77437684(+) GCTTTG/CACCAC 1 -- ds50013Minor allele frequency- C:0.14NA 124
    rs1882823211,2
    --77437705(+) GCTCCC/TTGCAA 1 -- ds50010--------
    rs1478874751,2
    C--77437942(+) GGCACA/GGGGCG 1 -- ds50010--------
    rs1415002641,2
    --77438049(+) GAATAC/TAAATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SOCS3 (76352859 - 76356158 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SOCS3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908880CNV Loss21882294
    nsv833555CNV Loss17160897
    nsv908881CNV Loss21882294
    nsv908882CNV Loss21882294

    Human Gene Mutation Database (HGMD): SOCS3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOCS3
    DNA2.0 Custom Variant and Variant Library Synthesis for SOCS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604176    OMIM disorders: --

    UniProtKB/Swiss-Prot: SOCS3_HUMAN, O14543
  • Note=There is some evidence that SOCS3 may be a susceptibility gene for atopic dermatitis linked to
    17q25. SOCS3 messenger RNA is significantly more highly expressed in skin from patients with atopic dermatitis
    than in skin from healthy controls. Furthermore, a genetic association between atopic dermatitis and a haplotype
    in the SOCS3 gene has been found in two independent groups of patients

  • 6 diseases for SOCS3:    
    About MalaCards
    primary polycythemia    allergic conjunctivitis    polycythemia    polycythemia vera
    insulin resistance    obesity

    2 diseases from the University of Copenhagen DISEASES database for SOCS3:
    Cancer     Diabetes mellitus

    Find genes that share disorders with SOCS3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SOCS3 gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 49.9 21 18171427 (2), 12475383 (2), 15169905 (2), 17327450 (2) (see all 12)
    leukemia 43 12 9811457 (2), 20372794 (1), 11714737 (1), 16616006 (1) (see all 10)
    polycythemia vera 42.6 6 18815196 (2), 16781479 (1), 17325857 (1)
    inflammation 40.5 23 20067961 (3), 20005910 (2), 15947106 (1), 17198696 (1) (see all 19)
    obesity 39.5 17 16299039 (3), 17445271 (2), 19083014 (2), 16402267 (1) (see all 10)
    insulin sensitivity 39 7 16402267 (2), 16920065 (2), 15249995 (1), 15072573 (1) (see all 5)
    hepatitis c chronic 36.6 8 19624774 (2), 17881539 (1), 16299039 (1), 17668875 (1) (see all 5)
    necrosis 34.3 17 16352613 (2), 15491991 (1), 18656467 (1), 20067961 (1) (see all 15)
    asthma allergic 29.4 1 16476192 (1)
    tumors 27.3 57 15385932 (4), 17376806 (3), 19996282 (3), 19738059 (2) (see all 33)

    Genetic Association Database (GAD): SOCS3
    Human Genome Epidemiology (HuGE) Navigator: SOCS3 (25 documents)

    Export disorders for SOCS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOCS3 gene, integrated from 10 sources (see all 598):
    (articles sorted by number of sources associating them with SOCS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PubMed id 9266833)1, 2, 3, 9 Minamoto S.... Kishimoto T. (Biochem. Biophys. Res. Commun. 1997)
    2. Cloning and characterization of novel CIS family genes. (PubMed id 9344848)1, 2, 3 Masuhara M.... Yoshimura A. (Biochem. Biophys. Res. Commun. 1997)
    3. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. (PubMed id 10421843)1, 2, 9 Sasaki A.... Yoshimura A. (Genes Cells 1999)
    4. Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study. (PubMed id 19083014)1, 4, 9 Talbert M.E....Bowden D.W. (Hum. Genet. 2009)
    5. A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. (PubMed id 12027890)1, 2, 9 Hoertner M.... Haan S. (Eur. J. Biochem. 2002)
    6. Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor. (PubMed id 11071852)1, 2, 9 Dey B.R.... Nissley P. (Biochem. Biophys. Res. Commun. 2000)
    7. Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. (PubMed id 16410555)1, 2, 9 Ben-Zvi T.... Monsonego-Ornan E. (J. Cell Sci. 2006)
    8. SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit. (PubMed id 14559241)1, 2, 9 Yamamoto K.... Miura O. (Biochem. Biophys. Res. Commun. 2003)
    9. Lack of association between the tagging SNP A+930--&gt;G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations. (PubMed id 19052638)1, 4, 9 Fischer-Rosinsky A....Spranger J. (PLoS ONE 2008)
    10. Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C. (PubMed id 17881539)1, 4, 9 Persico M....Iolascon A. (Gut 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9021 HGNC: 19391 AceView: SOCS3 Ensembl:ENSG00000184557 euGenes: HUgn9021
    ECgene: SOCS3 Kegg: 9021 H-InvDB: SOCS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOCS3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOCS3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOCS3 gene:
    Search GeneIP for patents involving SOCS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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