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Aliases for SOCS2 Gene

Aliases for SOCS2 Gene

  • Suppressor Of Cytokine Signaling 2 2 3 5
  • Cytokine-Inducible SH2 Protein 2 3 4
  • STAT-Induced STAT Inhibitor-2 2 3
  • STAT-Induced STAT Inhibitor 2 3 4
  • SOCS-2 3 4
  • STATI2 3 4
  • CIS-2 3 4
  • SSI-2 3 4
  • CIS2 3 4
  • SSI2 3 4
  • Suppressor Of Cytokine Signaling-2 3
  • STAT Induced STAT Inhibitor-2 3
  • Cish2 3

External Ids for SOCS2 Gene

Previous GeneCards Identifiers for SOCS2 Gene

  • GC12P094485
  • GC12P093896
  • GC12P092466
  • GC12P093963
  • GC12P091030

Summaries for SOCS2 Gene

Entrez Gene Summary for SOCS2 Gene

  • This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for SOCS2 Gene

SOCS2 (Suppressor Of Cytokine Signaling 2) is a Protein Coding gene. Diseases associated with SOCS2 include Vertebral Artery Occlusion. Among its related pathways are TGF-Beta Pathway and IL-2 Pathway. GO annotations related to this gene include SH3/SH2 adaptor activity and insulin-like growth factor receptor binding. An important paralog of this gene is SOCS7.

UniProtKB/Swiss-Prot for SOCS2 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for SOCS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS2 Gene

Genomics for SOCS2 Gene

Regulatory Elements for SOCS2 Gene

Enhancers for SOCS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SOCS2 on UCSC Golden Path with GeneCards custom track

Promoters for SOCS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SOCS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOCS2 Gene

Chromosome:
12
Start:
93,569,814 bp from pter
End:
93,626,236 bp from pter
Size:
56,423 bases
Orientation:
Plus strand

Genomic View for SOCS2 Gene

Genes around SOCS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOCS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOCS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS2 Gene

Proteins for SOCS2 Gene

  • Protein details for SOCS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14508-SOCS2_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 2
    Protein Accession:
    O14508
    Secondary Accessions:
    • A8K3D1
    • O14542
    • O95102
    • Q9UKS5

    Protein attributes for SOCS2 Gene

    Size:
    198 amino acids
    Molecular mass:
    22172 Da
    Quaternary structure:
    • Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.

    Three dimensional structures from OCA and Proteopedia for SOCS2 Gene

neXtProt entry for SOCS2 Gene

Proteomics data for SOCS2 Gene at MOPED

Post-translational modifications for SOCS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SOCS2 (SOCS2)
  • Cloud-Clone Corp. Antibodies for SOCS2

No data available for DME Specific Peptides for SOCS2 Gene

Domains & Families for SOCS2 Gene

Protein Domains for SOCS2 Gene

Graphical View of Domain Structure for InterPro Entry

O14508

UniProtKB/Swiss-Prot:

SOCS2_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 SH2 domain.
  • Contains 1 SOCS box domain.
genes like me logo Genes that share domains with SOCS2: view

Function for SOCS2 Gene

Molecular function for SOCS2 Gene

GENATLAS Biochemistry:
suppressor of cytokine signaling 2. Involved in the interleukin-6 induced receptor phosphorylation and in the negative regulation of cytokine induced STAT factor signaling,putative candidate for asthma and atopy susceptibility
UniProtKB/Swiss-Prot Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
UniProtKB/Swiss-Prot Induction:
By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF.

Gene Ontology (GO) - Molecular Function for SOCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 9344848
GO:0005131 growth hormone receptor binding NAS 12135564
GO:0005515 protein binding IPI 11781573
genes like me logo Genes that share ontologies with SOCS2: view
genes like me logo Genes that share phenotypes with SOCS2: view

Animal Models for SOCS2 Gene

MGI Knock Outs for SOCS2:

Animal Model Products

miRNA for SOCS2 Gene

miRTarBase miRNAs that target SOCS2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS2 Gene

Localization for SOCS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOCS2 Gene COMPARTMENTS Subcellular localization image for SOCS2 gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SOCS2 Gene

Pathways & Interactions for SOCS2 Gene

genes like me logo Genes that share pathways with SOCS2: view

UniProtKB/Swiss-Prot O14508-SOCS2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SOCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 9727029
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0007259 JAK-STAT cascade TAS 9266833
GO:0009966 regulation of signal transduction NAS 9727029
GO:0032355 response to estradiol IDA 12552091
genes like me logo Genes that share ontologies with SOCS2: view

No data available for SIGNOR curated interactions for SOCS2 Gene

Drugs & Compounds for SOCS2 Gene

(3) Drugs for SOCS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SOCS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SOCS2: view

Transcripts for SOCS2 Gene

Unigene Clusters for SOCS2 Gene

Suppressor of cytokine signaling 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -
SP9: -
SP10:

Relevant External Links for SOCS2 Gene

GeneLoc Exon Structure for
SOCS2
ECgene alternative splicing isoforms for
SOCS2

Expression for SOCS2 Gene

mRNA expression in normal human tissues for SOCS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SOCS2 Gene

This gene is overexpressed in Bone (49.8), Liver (9.5), and Heart (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOCS2 Gene



SOURCE GeneReport for Unigene cluster for SOCS2 Gene Hs.485572

mRNA Expression by UniProt/SwissProt for SOCS2 Gene

O14508-SOCS2_HUMAN
Tissue specificity: High expression in heart, placenta, lung, kidney and prostate.
genes like me logo Genes that share expression patterns with SOCS2: view

Protein tissue co-expression partners for SOCS2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for SOCS2 Gene

Orthologs for SOCS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SOCS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SOCS2 35
  • 94.44 (n)
  • 94.44 (a)
SOCS2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOCS2 35
  • 95.45 (n)
  • 94.44 (a)
SOCS2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Socs2 35
  • 90.91 (n)
  • 93.94 (a)
Socs2 16
Gm9847 36
  • 93 (a)
OneToMany
Socs2 36
  • 94 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SOCS2 35
  • 99.83 (n)
  • 99.49 (a)
SOCS2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Socs2 35
  • 89.39 (n)
  • 93.43 (a)
oppossum
(Monodelphis domestica)
Mammalia SOCS2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOCS2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOCS2 35
  • 72.71 (n)
  • 81.21 (a)
SOCS2 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOCS2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia socs2 35
  • 67.17 (n)
  • 64.47 (a)
Str.4310 35
zebrafish
(Danio rerio)
Actinopterygii socs2 35
  • 57.89 (n)
  • 57.37 (a)
socs2 36
  • 56 (a)
OneToOne
Species with no ortholog for SOCS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOCS2 Gene

ENSEMBL:
Gene Tree for SOCS2 (if available)
TreeFam:
Gene Tree for SOCS2 (if available)

Paralogs for SOCS2 Gene

Paralogs for SOCS2 Gene

(4) SIMAP similar genes for SOCS2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SOCS2 Gene

genes like me logo Genes that share paralogs with SOCS2: view

Variants for SOCS2 Gene

Sequence variations from dbSNP and Humsavar for SOCS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs3741676 - 93,574,737(-) TCATA(C/G/T)TTCCC nc-transcript-variant, reference, missense
rs2055304 -- 93,617,255(-) TAAAA(A/T)TCCCA intron-variant
rs2055305 -- 93,617,183(-) TTATT(A/G)CACCT intron-variant
rs2072593 -- 93,576,250(+) GGTAA(C/T)AGAGG intron-variant, utr-variant-3-prime
rs9767 -- 93,575,921(+) TCAAT(A/C)CCCGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SOCS2 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
esv25615 CNV Loss 19812545

Variation tolerance for SOCS2 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SOCS2 Gene

Disorders for SOCS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SOCS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vertebral artery occlusion
  • occlusion and stenosis of vertebral artery
- elite association - COSMIC cancer census association via MalaCards
Search SOCS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SOCS2

Genetic Association Database (GAD)
SOCS2
Human Genome Epidemiology (HuGE) Navigator
SOCS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOCS2
genes like me logo Genes that share disorders with SOCS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOCS2 Gene

Publications for SOCS2 Gene

  1. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PMID: 9266833) Minamoto S. … Kishimoto T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23 67
  2. Changes in the expression of suppressor of cytokine signalling (SOCS) 2 in the colonic mucosa of acromegalic patients are associated with hyperplastic polyps. (PMID: 18844680) Bogazzi F. … Martino E. (Clin. Endocrinol. (Oxf) 2009) 3 23
  3. HIV-1 transactivator protein induction of suppressor of cytokine signaling-2 contributes to dysregulation of IFN{gamma} signaling. (PMID: 19279332) Cheng S.M. … Lau A.S. (Blood 2009) 3 23
  4. SOCS2 influences LPS induced human monocyte-derived dendritic cell maturation. (PMID: 19779605) Hu J. … Norstedt G. (PLoS ONE 2009) 3 23
  5. SOCS2: inhibitor of JAK2V617F-mediated signal transduction. (PMID: 18769447) Quentmeier H. … Drexler H.G. (Leukemia 2008) 3 23

Products for SOCS2 Gene

Sources for SOCS2 Gene

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