SOCS2 Gene

Aliases
for SOCS2 gene

Previous GC identifers: GC12P094485 GC12P093896 GC12P092466 GC12P091030

Summaries
for SOCS2 gene

Genomic Views
for SOCS2 gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_029419.12  

SwitchGear Promoter luciferase reporter plasmids (see all 7): SOCS2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOCS2

SOCS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P093963:  view genomic region     (about GC identifiers)

Proteins
for SOCS2 gene

1 PDB 3D structure from and Proteopedia for SOCS2:

2C9W (3D)    

Explore the universe of human proteins at neXtProt for SOCS2: NX_O14508

SOCS2 Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SOCS2 OriGene Custom Protein Services for SOCS2
	GenScript Custom Purified and Recombinant Proteins Services for SOCS2
	Novus Biologicals SOCS2 Proteins Novus Biologicals SOCS2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SOCS2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SOCS2 (SOCS-2)
	Cell Signaling Technology (CST) Antibodies for SOCS2
	OriGene Antibodies: SOCS2 OriGene Custom Antibody Services for SOCS2
	GenScript Custom Superior Antibodies Services for SOCS2
	Novus Biologicals SOCS2 Antibodies
	Abcam antibodies for SOCS2
	Uscn Antibodies for SOCS2
	ThermoFisher Antibodies for SOCS2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SOCS2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SOCS2

Protein Domains /
Families
for SOCS2 gene

ProtoNet protein and cluster: O14508

Function
for SOCS2 gene

miRNA Products:		miRTarBase miRNAs that target SOCS2: hsa-mir-194 (MIRT005896)
		OriGene 3'-UTR Clone: SOCS2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOCS2
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SOCS2 (see all 24):
		hsa-miR-448 hsa-miR-4311 hsa-miR-767-5p hsa-miR-139-5p hsa-miR-578 hsa-miR-507 hsa-miR-374c hsa-miR-511
		SwitchGear 3'UTR luciferase reporter plasmid: SOCS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOCS2 (see all 7) OriGene shRNA RFP: SOCS2 OriGene siRNA: SOCS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOCS2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SOCS2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOCS2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOCS2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOCS2 (NM_003877)
		Sino Biological Human cDNA Clone for SOCS2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SOCS2
		Search LifeMap BioReagents cell lines for SOCS2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

(inferred from 2 alleles) (MGI details for Socs2)

Pathways & Interactions
for SOCS2 gene

	Super-pathway	contained gene-specific pathways
1	IL-9 Signaling Pathways	Immune response_IL-9 signaling pathway 0.42 IL-9 Pathway 0.22 Immune response IL-9 signaling pathway 0.42
2	ErbB4 Pathway	Prolactin Signaling 0.54 IL-4 Pathway 0.28 Growth Hormone Signaling 0.32
3	PEDF Induced Signaling	IL-6 Pathway 0.61 STAT3 Pathway 0.47
4	Development_Prolactin receptor signaling	Prolactin Signaling Pathway 0.39 Leptin signaling pathway 0.32
5	TGF-Beta Pathway	JAK-STAT Pathway 0.57 SOCS Pathway 0.29

1 EMD Millipore Pathway for SOCS2

Immune response IL-9 signaling pathway

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SOCS2

	IL-9 Pathway
	Growth Hormone Signaling
	STAT3 Pathway
	IL-4 Pathway
	Prolactin Signaling

1 Cell Signaling Technology (CST) Pathway for SOCS2

Jak/Stat Pathway

2 GeneGo (Thomson Reuters) Pathways for SOCS2

	Immune response IL-9 signaling pathway
	Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

4 BioSystems Pathways for SOCS2

	IL-3 Signaling Pathway
	Prolactin Signaling Pathway
	Leptin signaling pathway
	IL2-mediated signaling events

3        Reactome Pathways for SOCS2

	Cytokine Signaling in Immune system
	Growth hormone receptor signaling
	Immune System

3         Kegg Pathways  (Kegg details for SOCS2)

	Jak-STAT signaling pathway
	Insulin signaling pathway
	Type II diabetes mellitus

SOCS2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SOCS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/69 Interacting proteins for SOCS2 (O14508^{1, 2, 3} ENSP00000339428⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 69)

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

Drugs & Compounds
for SOCS2 gene

Transcripts
for SOCS2 gene

Expression
for SOCS2 gene

SOCS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACATAAACA

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyUreteric Bud			Kidney
	TestisSeminiferous Tubules			Testis
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)			Heart, Myocardium, Smooth Muscle
	PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOCS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SOCS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOCS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOCS2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS2

Orthologs
for SOCS2 gene

Paralogs
for SOCS2 gene

Paralogs for SOCS2 gene

SOCS3²  SOCS4²  SOCS5²  SOCS7²  SOCS6²  SOCS1²  CISH²  

5 SIMAP similar genes for SOCS2 using alignment to 5 protein entries:     SOCS2_HUMAN (see all proteins):

CISH    SOCS6    SOCS7    SOCS1    SOCS3

SOCS2 for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for SOCS2
PGOHUM00000261326 PGOHUM00000246268 PGOHUM00000246609

Genomic Variants
for SOCS2 gene

10/152 NCBI SNPs in SOCS2 are shown (see all 152)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs415107441,2	C,	--	91031173(+)	GACGAC/GCACGG	1	--	us2k1		0	--	--	--	--
rs414178461,2	C,	--	91033949(+)	CGCAGA/GCCCAG	1	--	us2k1		0	--	--	--	--
rs1847628401,2		--	93961604(+)	CAACAG/TCCCTG	2	--	int1 us2k1		0	--	--	--	--
rs1491114081,2		--	93961636(+)	CTCCAA/GAAGAG	2	--	int1 us2k1		0	--	--	--	--
rs413483441,2	C,	--	93961727(+)	GCCATA/GGTGCT	2	--	us2k1 int1		0	--	--	--	--
rs1481896351,2		--	93961800(+)	GATGCC/TTACTA	2	--	int1 us2k1		0	--	--	--	--
rs1868116941,2		--	93961805(+)	CTACTA/GCATGC	2	--	int1 us2k1		0	--	--	--	--
rs1402163741,2		--	93961839(+)	AACTAC/GAGCTG	2	--	int1 us2k1		0	--	--	--	--
rs1922187391,2		--	93962170(+)	GGAGTC/TCAGTG	2	--	int1 us2k1		0	--	--	--	--
rs414421511,2	C,	--	93962260(+)	CGTCTC/GGGCTC	3	--	us2k1 int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for SOCS2 (93963590 - 93977263 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SOCS2
     1 CNV: 66303

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOCS2

DNA2.0 Custom Variant and Variant Library Synthesis for SOCS2

Disorders / Diseases
for SOCS2 gene

20/36 diseases for SOCS2

10 Novoseek disease relationships for SOCS2 gene    About this table

Publications
for SOCS2 gene

PubMed articles for SOCS2 gene, integrated from 9 sources (see all 152): (articles sorted by number of sources associating them with SOCS2)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PubMed id 9266833)^{1, 2, 3, 9} Minamoto S.... Kishimoto T. (1997)
2. Cloning and characterization of novel CIS family genes. (PubMed id 9344848)^{1, 2, 3} Masuhara M.... Yoshimura A. (1997)
3. Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. (PubMed id 16675548)^{1, 2} Bullock A.N.... Knapp S. (2006)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively. (PubMed id 10512686)^{1, 2} Yandava C.N.... Drazen J.M. (1999)
6. Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. (PubMed id 9727029)^{1, 2} Dey B.R.... Furlanetto R.W. (1998)
7. Favorable prognostic value of SOCS2 and IGF-I in breast cancer. (PubMed id 17651480)^{1, 9} Haffner M.C....Doppler W. (2007)
8. Changes in the expression of suppressor of cytokine s ignalling (SOCS) 2 in the colonic mucosa of acromegalic patients are associated with hyperplastic polyps. (PubMed id 18844680)^{1, 9} Bogazzi F....Martino E. (2009)
9. Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism. (PubMed id 11861294)^{1, 9} Schultheis B....Melo J.V. (2002)
10. SOCS2 influences LPS induced human monocyte-derived d endritic cell maturation. (PubMed id 19779605)^{1, 9} Hu J....Norstedt G. (2009)

External Searches for SOCS2 gene

Genome Databases showing SOCS2 gene

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Products
for SOCS2 gene