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SOCS2 Gene

protein-coding   GIFtS: 66
GCID: GC12P093963

Suppressor Of Cytokine Signaling 2

  See SOCS2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Cytokine Signaling 21 2     SSI22 3
STAT-Induced STAT Inhibitor-21 2     STATI22 3
Cytokine-Inducible SH2 Protein 22 3     STAT-Induced STAT Inhibitor 22 3
CIS-22 3     Cish22
CIS22 3     STAT Induced STAT Inhibitor-22
SOCS-22 3     Suppressor Of Cytokine Signaling-22
SSI-22 3     

External Ids:    HGNC: 193821   Entrez Gene: 88352   Ensembl: ENSG000001208337   OMIM: 6051175   UniProtKB: O145083   

Export aliases for SOCS2 gene to outside databases

Previous GC identifers: GC12P094485 GC12P093896 GC12P092466 GC12P091030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOCS2 Gene:
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are
cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and
activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of
signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or
signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of
cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as
growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like
growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell
signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jul 2012)

GeneCards Summary for SOCS2 Gene:
SOCS2 (suppressor of cytokine signaling 2) is a protein-coding gene. Diseases associated with SOCS2 include primary polycythemia, and chronic myeloid leukemia. GO annotations related to this gene include SH3/SH2 adaptor activity and growth hormone receptor binding. An important paralog of this gene is SOCS3.

UniProtKB/Swiss-Prot: SOCS2_HUMAN, O14508
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable
substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein
ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Gene Wiki entry for SOCS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOCS2 gene promoter:
         STAT5B   PPAR-gamma1   PPAR-gamma2   Tal-1beta   ITF-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): SOCS2 promoter sequence
   Search Chromatin IP Primers for SOCS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOCS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q

SOCS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P093963:  view genomic region     (about GC identifiers)

Start:
93,963,590 bp from pter      End:
93,977,263 bp from pter
Size:
13,674 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SOCS2_HUMAN, O14508 (See protein sequence)
Recommended Name: Suppressor of cytokine signaling 2  
Size: 198 amino acids; 22172 Da
Subunit: Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the
Elongin BC complex
2 PDB 3D structures from and Proteopedia for SOCS2:
2C9W (3D)        4JGH (3D)    
Secondary accessions: A8K3D1 O14542 O95102 Q9UKS5

Explore the universe of human proteins at neXtProt for SOCS2: NX_O14508

Explore proteomics data for SOCS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SOCS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001257396.1  NP_001257397.1  NP_001257398.1  NP_001257399.1  NP_001257400.1  NP_003868.1  

    ENSEMBL proteins: 
     ENSP00000339428   ENSP00000448815   ENSP00000442898   ENSP00000447902   ENSP00000447161  
     ENSP00000448709   ENSP00000448611   ENSP00000449227   ENSP00000473902   ENSP00000474805  
     ENSP00000474888  
    Reactome Protein details: O14508

    SOCS2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SOCS2
    OriGene Custom MassSpec
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    Novus Biologicals SOCS2 Proteins
    Novus Biologicals SOCS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOCS2

     
    Search eBioscience for Proteins for SOCS2 

     
    antibodies-online proteins for SOCS2 (5 products) 

     
    antibodies-online peptides for SOCS2

    SOCS2 Antibody Products:

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    antibodies-online antibodies for SOCS2 (55 products) 

    SOCS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SOCS2
    Cloud-Clone Corp. CLIAs for SOCS2
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    antibodies-online kits for SOCS2 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SOCS: Suppressors of cytokine signaling
    SH2D: SH2 domain containing

    4 InterPro protein domains:
     IPR001496 SOCS_C
     IPR000980 SH2
     IPR028413 SOCS
     IPR028410 SOCS2

    Graphical View of Domain Structure for InterPro Entry O14508

    ProtoNet protein and cluster: O14508

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001496 SOCS protein


    UniProtKB/Swiss-Prot: SOCS2_HUMAN, O14508
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SOCS box domain


    Find genes that share domains with SOCS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOCS2_HUMAN, O14508
    Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
    transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable
    substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein
    ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
    Induction: By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF

         Genatlas biochemistry entry for SOCS2:
    suppressor of cytokine signaling 2. Involved in the interleukin-6 induced receptor phosphorylation and in the
    negative regulation of cytokine induced STAT factor signaling,putative candidate for asthma and atopy
    susceptibility

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS9344848
    GO:0005131growth hormone receptor binding NAS12135564
    GO:0005148prolactin receptor binding ----
    GO:0005159insulin-like growth factor receptor binding IPI9727029
    GO:0005515protein binding IPI11781573
         
    Find genes that share ontologies with SOCS2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SOCS2:
     Cell cycle / mitosis defect  Decreased cell number and incr  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         13 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Socs2):
     adipose tissue  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 
     renal/urinary system  respiratory system  skeleton 

    Find genes that share phenotypes with SOCS2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SOCS2

    miRNA
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    miRTarBase miRNAs that target SOCS2:
    hsa-mir-16-5p (MIRT051211), hsa-mir-194-5p (MIRT005896), hsa-mir-7-5p (MIRT025940)

    Block miRNA regulation of human, mouse, rat SOCS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOCS2 (see all 24):
    hsa-miR-448 hsa-miR-4311 hsa-miR-767-5p hsa-miR-139-5p hsa-miR-578 hsa-miR-507 hsa-miR-374c hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidSOCS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOCS2
    Predesigned siRNA for gene silencing in human, mouse, rat SOCS2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SOCS2 (see all 10)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOCS2 (NM_003877)
    Sino Biological Human cDNA Clone for SOCS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SOCS2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    plasma membrane2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS9727029
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SOCS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOCS2 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Prolactin Signaling Pathway
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33
    Leptin signaling pathway0.35
    2IL-9 Signaling Pathways
    Immune response IL 9 signaling pathway0.42
    IL-9 Pathway0.36
    3ErbB4 Pathway
    Prolactin Signaling0.54
    IL-4 Pathway0.34
    Growth Hormone Signaling0.49
    4PEDF Induced Signaling
    IL-6 Pathway0.61
    STAT3 Pathway0.47
    5TGF-Beta Pathway
    JAK-STAT Pathway0.57
    SOCS Pathway0.40


    Find genes that share SuperPaths with SOCS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SOCS2 (see all 8)
        IL-9 Pathway
    Growth Hormone Signaling
    STAT3 Pathway
    IL-4 Pathway
    Prolactin Signaling

    1 Cell Signaling Technology (CST) Pathway for SOCS2
        Jak/Stat Pathway

    2 GeneGo (Thomson Reuters) Pathways for SOCS2
        Immune response IL-9 signaling pathway
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

    4 BioSystems Pathways for SOCS2
        IL-3 Signaling Pathway
    Leptin signaling pathway
    Prolactin Signaling Pathway
    IL2-mediated signaling events


    1 Reactome Pathway for SOCS2
        Growth hormone receptor signaling


    4 Kegg Pathways  (Kegg details for SOCS2):
        Jak-STAT signaling pathway
    Insulin signaling pathway
    Prolactin signaling pathway
    Type II diabetes mellitus

    UniProtKB/Swiss-Prot: SOCS2_HUMAN, O14508
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOCS2: 

              Apoptosis 384HT in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SOCS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SOCS2 (O145081, 2, 3 ENSP000003394284) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GHRP109122, 3, ENSP000002308824MINT-8028464 I2D: score=4 STRING: ENSP00000230882
    TCEB1Q153691, 2, 3, ENSP000002848114EBI-617737,EBI-301231 MINT-2835885 I2D: score=3 STRING: ENSP00000284811
    EPORP192351, 2, 3, ENSP000002221394EBI-617737,EBI-617321 MINT-8037163 I2D: score=4 STRING: ENSP00000222139
    IGF1RP080693, ENSP000002680354I2D: score=3 STRING: ENSP00000268035
    SOCS1O155243, ENSP000003294184I2D: score=2 STRING: ENSP00000329418
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS9727029
    GO:0007259JAK-STAT cascade TAS9266833
    GO:0007568aging IEA--
    GO:0009966regulation of signal transduction NAS9727029
    GO:0009967positive regulation of signal transduction TAS9344848

    Find genes that share ontologies with SOCS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SOCS2

    5 Novoseek inferred chemical compound relationships for SOCS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 46.2 6 10585430 (2), 10491180 (1), 16033816 (1), 12734778 (1) (see all 5)
    ifn-alpha 43.2 3 16623280 (1), 11340296 (1)
    imatinib 27.2 5 11861294 (5)
    phosphatidylinositol 20.2 4 18165436 (1), 11279166 (1), 15644415 (1), 12396724 (1)
    estrogen 0 10 15319356 (4), 12552091 (2), 17272397 (2)



    Find genes that share compounds with SOCS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SOCS2 gene (6 alternative transcripts): 
    NM_001270467.1  NM_001270468.1  NM_001270469.1  NM_001270470.1  NM_001270471.1  NM_003877.4  

    Unigene Cluster for SOCS2:

    Suppressor of cytokine signaling 2
    Hs.485572  [show with all ESTs]
    Unigene Representative Sequence: NM_001270467
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340600(uc001tcw.1) ENST00000549206 ENST00000536696 ENST00000548091
    ENST00000549122(uc021rbx.1 uc001tcy.1) ENST00000548537(uc001tcz.3)
    ENST00000549887 ENST00000551556 ENST00000547229 ENST00000551883 ENST00000549510

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SOCS2 (see all 24):
    hsa-miR-448 hsa-miR-4311 hsa-miR-767-5p hsa-miR-139-5p hsa-miR-578 hsa-miR-507 hsa-miR-374c hsa-miR-511
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SOCS2
      QuantiFast Probe-based Assays in human, mouse, rat SOCS2

    Additional mRNA sequence: 

    AB004903.1 AB006966.1 AB451318.1 AF037989.1 AK290546.1 AK297662.1 AK313165.1 BC010399.1 

    9 DOTS entries:

    DT.317276  DT.121126609  DT.100790470  DT.100036041  DT.101956172  DT.95174534  DT.121126598  DT.40121601 
    DT.92072016 

    Selected AceView cDNA sequences (see all 217):

    AA513372 AI160597 BM561681 AI086984 AI582491 BP379918 AI223851 AB004903 
    AW157746 AI147628 BE645252 BQ025748 BI335340 BQ022888 AI129818 BG536337 
    BE047696 AA983826 AI080406 BI966003 AL161980 AI565994 AA235067 BU675568 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SOCS2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10
    SP1:        -     -     -     -     -     -     -     -                 -                                                   
    SP2:              -     -     -     -     -     -     -                 -                                                   
    SP3:                    -     -     -     -     -     -                 -                                                   
    SP4:                          -     -     -     -     -                 -                                                   
    SP5:                                      -     -     -                 -                                                   


    ECgene alternative splicing isoforms for SOCS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOCS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACATAAACA
    SOCS2 Expression
    About this image


    SOCS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    SOCS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOCS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485572

    UniProtKB/Swiss-Prot: SOCS2_HUMAN, O14508
    Tissue specificity: High expression in heart, placenta, lung, kidney and prostate

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SOCS2: 
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              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SOCS2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Socs21 , 5 suppressor of cytokine signaling 21, 5 90.91(n)1
    93.94(a)1
      10 (49.35 cM)5
    2162331  NM_001168655.11  NP_001162126.11 
     953853625 
    chicken
    (Gallus gallus)
    Aves SOCS21 suppressor of cytokine signaling 2 72.71(n)
    81.21(a)
      395219  NM_204540.1  NP_989871.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOCS26
    suppressor of cytokine signaling 2
    69(a)
    1 ↔ 1
    5(31408022-31412753)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.43102 Transcribed sequence with weak similarity to protein more 79.7(n)    AL850212.2 
    zebrafish
    (Danio rerio)
    Actinopterygii socs21 suppressor of cytokine signaling 2 57.89(n)
    57.37(a)
      562062  NM_001114550.1  NP_001108022.1 


    ENSEMBL Gene Tree for SOCS2 (if available)
    TreeFam Gene Tree for SOCS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOCS2 gene
    SOCS32  SOCS42  SOCS52  SOCS72  SOCS12  SOCS62  CISH2  
    4 SIMAP similar genes for SOCS2 using alignment to 7 protein entries:     SOCS2_HUMAN (see all proteins):
    CISH    SOCS6    SOCS7    SOCS1

    Find genes that share paralogs with SOCS2           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for SOCS2
    PGOHUM00000261326 PGOHUM00000246268 PGOHUM00000246609


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOCS2 (see all 108)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161702791,2
    F--91031082(+) GGCGCC/TGCTTA 1 -- us2k11Minor allele frequency- T:0.10WA 118
    rs415107441,2
    C--91031173(+) GACGAC/GCACGG 1 -- us2k10--------
    rs1886472241,2
    --93967640(+) GGGGTA/GGGGGG 6 -- int10--------
    rs1379040571,2
    --93967645(+) GGGGGC/GAGCAC 6 -- int10--------
    rs414155441,2
    C--93967724(+) TGGTGC/TAGGCA 6 -- int10--------
    rs37824151,2
    C,F,A,H--93967755(-) CATCCA/GTCTCC 6 -- int124Minor allele frequency- G:0.31EA MN NS NA WA 4218
    rs414654481,2
    C,F--93967760(+) TGGATG/AGTTGT 6 -- int12Minor allele frequency- A:0.04WA 120
    rs1430932091,2
    --93967783(+) ATTAGA/GGCAAA 6 -- int10--------
    rs1927857151,2
    --93967850(+) TTCCCA/CTTTCT 6 -- int10--------
    rs13894991,2
    C,H--93967943(-) ATGTAG/AAAAGC 6 -- int11Minor allele frequency- A:0.00NS 112

    HapMap Linkage Disequilibrium report for SOCS2 (93963590 - 93977263 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SOCS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv25615CNV Loss19812545
    nsv7234OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SOCS2
    DNA2.0 Custom Variant and Variant Library Synthesis for SOCS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605117    OMIM disorders: --

    2 diseases for SOCS2:    
    About MalaCards
    primary polycythemia    chronic myeloid leukemia


    Find genes that share disorders with SOCS2           About GenesLikeMe

    10 Novoseek inferred disease relationships for SOCS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 23.7 2 9266833 (1), 10969179 (1)
    myeloid leukemia chronic 5.96 1 11861294 (1)
    inflammation 3.48 1 16623280 (1)
    renal failure chronic 0 1 15723195 (1)
    necrosis 0 1 15491991 (1)
    breast cancer 0 6 17651480 (3), 17272397 (2), 16189149 (1)
    tumors 0 9 15491991 (1), 16410303 (1), 16707422 (1), 16374457 (1) (see all 7)
    carcinoma 0 1 17651480 (1)
    melanoma 0 4 16374457 (3), 18627528 (1)
    cancer 0 2 16125365 (1), 17001312 (1)

    Genetic Association Database (GAD): SOCS2
    Human Genome Epidemiology (HuGE) Navigator: SOCS2 (17 documents)

    Export disorders for SOCS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOCS2 gene, integrated from 10 sources (see all 162):
    (articles sorted by number of sources associating them with SOCS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PubMed id 9266833)1, 2, 3, 9 Minamoto S.... Kishimoto T. (Biochem. Biophys. Res. Commun. 1997)
    2. Cloning and characterization of novel CIS family genes. (PubMed id 9344848)1, 2, 3 Masuhara M.... Yoshimura A. (Biochem. Biophys. Res. Commun. 1997)
    3. Association of single-nucleotide polymorphisms in the suppressor of cytokine signaling 2 (SOCS2) gene with type 2 diabetes in the Japanese. (PubMed id 16406727)1, 4, 9 Kato H....Itakura M. (Genomics 2006)
    4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    6. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. A multiplex MALDI-TOF MS approach facilitates genotyping of DNA from formalin-fixed paraffin-embedded tumour specimens. (PubMed id 20802378)1, 4 Horn H....Schaeffeler E. (Pharmacogenet. Genomics 2010)
    9. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8835 HGNC: 19382 AceView: SOCS2 Ensembl:ENSG00000120833 euGenes: HUgn8835
    ECgene: SOCS2 Kegg: 8835 H-InvDB: SOCS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOCS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SOCS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOCS2 gene:
    Search GeneIP for patents involving SOCS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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