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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOCS2 Gene

protein-coding   GIFtS: 67
GCID: GC12P093963

Suppressor Of Cytokine Signaling 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppressor Of Cytokine Signaling 21 2     SSI22 3
STAT-Induced STAT Inhibitor-21 2     STATI22 3
Cytokine-Inducible SH2 Protein 22 3     STAT-Induced STAT Inhibitor 22 3
CIS-22 3     Cish22
CIS22 3     STAT Induced STAT Inhibitor-22
SOCS-22 3     Suppressor Of Cytokine Signaling-22
SSI-22 3     

External Ids:    HGNC: 193821   Entrez Gene: 88352   Ensembl: ENSG000001208337   OMIM: 6051175   UniProtKB: O145083   

Export aliases for SOCS2 gene to outside databases

Previous GC identifers: GC12P094485 GC12P093896 GC12P092466 GC12P091030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOCS2 Gene:
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are
cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and
activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of
signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or
signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of
cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as
growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like
growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell
signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jul 2012)

GeneCards Summary for SOCS2 Gene: 
SOCS2 (suppressor of cytokine signaling 2) is a protein-coding gene. Diseases associated with SOCS2 include placental insufficiency, and gigantism, and among its related super-pathways are Development Prolactin receptor signaling and IL-9 Signaling Pathways. GO annotations related to this gene include SH3/SH2 adaptor activity and growth hormone receptor binding. An important paralog of this gene is SOCS3.

UniProtKB/Swiss-Prot: SOCS2_HUMAN, O14508
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable
substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein
ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Gene Wiki entry for SOCS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOCS2 gene promoter:
         STAT5B   PPAR-gamma1   PPAR-gamma2   Tal-1beta   ITF-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): SOCS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOCS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOCS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q

SOCS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P093963:  view genomic region     (about GC identifiers)

Start:
93,963,590 bp from pter      End:
93,977,263 bp from pter
Size:
13,674 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SOCS2_HUMAN, O14508 (See protein sequence)
Recommended Name: Suppressor of cytokine signaling 2  
Size: 198 amino acids; 22172 Da
Subunit: Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the
Elongin BC complex
1 PDB 3D structure from and Proteopedia for SOCS2:
2C9W (3D)    
Secondary accessions: A8K3D1 O14542 O95102 Q9UKS5

Explore the universe of human proteins at neXtProt for SOCS2: NX_O14508

Explore proteomics data for SOCS2 at MOPED 

SOCS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SOCS2 Protein Expression

REFSEQ proteins (6 alternative transcripts): 
NP_001257396.1  NP_001257397.1  NP_001257398.1  NP_001257399.1  NP_001257400.1  NP_003868.1  

ENSEMBL proteins: 
 ENSP00000339428   ENSP00000448815   ENSP00000442898   ENSP00000447902   ENSP00000447161  
 ENSP00000448709   ENSP00000448611   ENSP00000449227   ENSP00000473902   ENSP00000474805  
 ENSP00000474888  
Reactome Protein details: O14508
Human Recombinant Protein Products for SOCS2: 
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Novus Biologicals SOCS2 Proteins
Novus Biologicals SOCS2 Lysate
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for SOCS2 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm NAS9727029
GO:0005829cytosol TAS--

SOCS2 for ontologies           About GeneDecksing



SOCS2 Antibody Products: 
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Cloud-Clone Corp. ELISAs for SOCS2 
Cloud-Clone Corp. CLIAs for SOCS2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
SOCS: Suppressors of cytokine signaling
SH2D: SH2 domain containing

2 InterPro protein domains:
 IPR001496 SOCS_C
 IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry O14508

ProtoNet protein and cluster: O14508

2 Blocks protein domains:
IPB000980 SH2 domain signature
IPB001496 SOCS protein


UniProtKB/Swiss-Prot: SOCS2_HUMAN, O14508
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
E3 ubiquitin ligase complexes
Similarity: Contains 1 SH2 domain
Similarity: Contains 1 SOCS box domain


SOCS2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SOCS2_HUMAN, O14508
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable
substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein
ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
Induction: By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF

     Genatlas biochemistry entry for SOCS2:
suppressor of cytokine signaling 2. Involved in the interleukin-6 induced receptor phosphorylation and in the
negative regulation of cytokine induced STAT factor signaling,putative candidate for asthma and atopy
susceptibility

     Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005070SH3/SH2 adaptor activity TAS9344848
GO:0005131growth hormone receptor binding NAS12135564
GO:0005148prolactin receptor binding NAS--
GO:0005159insulin-like growth factor receptor binding IPI9727029
GO:0005515protein binding IPI11781573
     
SOCS2 for ontologies           About GeneDecksing


Phenotypes:
     4 GenomeRNAi human phenotypes for SOCS2:
 Cell cycle / mitosis defect  Decreased cell number and incr  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

     12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Socs2):
 adipose tissue  digestive/alimentary  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
 immune system  integument  limbs/digits/tail  liver/biliary system  renal/urinary system 
 respiratory system  skeleton 

SOCS2 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for SOCS2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SOCS2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOCS2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOCS2 

miRNA
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miRTarBase miRNAs that target SOCS2:
hsa-mir-194 (MIRT005896)

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8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SOCS2 (see all 24):
hsa-miR-448 hsa-miR-4311 hsa-miR-767-5p hsa-miR-139-5p hsa-miR-578 hsa-miR-507 hsa-miR-374c hsa-miR-511
SwitchGear 3'UTR luciferase reporter plasmidSOCS2 3' UTR sequence
Inhib. RNA
Products:
    
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Gene Editing
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Clone
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OriGene ORF clones in mouse, rat for SOCS2
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GenScript: all cDNA clones in your preferred vector: SOCS2 (NM_003877)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS2
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Cell Line
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Search LifeMap BioReagents cell lines for SOCS2
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SOCS2 About   (see all 15)                                                                                              See pathways by source

SuperPathContained pathways About
1Development Prolactin receptor signaling
Prolactin Signaling Pathway0.39
Prolactin signaling pathway0.33
Leptin signaling pathway0.35
2Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
Immune response IL-9 signaling pathway0.42
IL-9 Pathway0.36
3ErbB4 Pathway
Prolactin Signaling0.54
IL-4 Pathway0.34
Growth Hormone Signaling0.49
4PEDF Induced Signaling
IL-6 Pathway0.61
STAT3 Pathway0.47
5TGF-Beta Pathway
JAK-STAT Pathway0.57
SOCS Pathway0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for SOCS2
    Immune response IL-9 signaling pathway

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SOCS2 (see all 8)
    IL-9 Pathway
Growth Hormone Signaling
STAT3 Pathway
IL-4 Pathway
Prolactin Signaling

1 Cell Signaling Technology (CST) Pathway for SOCS2
    Jak/Stat Pathway

2 GeneGo (Thomson Reuters) Pathways for SOCS2
    Immune response IL-9 signaling pathway
Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

4 BioSystems Pathways for SOCS2
    IL-3 Signaling Pathway
Leptin signaling pathway
Prolactin Signaling Pathway
IL2-mediated signaling events


3        Reactome Pathways for SOCS2
    Cytokine Signaling in Immune system
Growth hormone receptor signaling
Immune System


4         Kegg Pathways  (Kegg details for SOCS2):
    Jak-STAT signaling pathway
Insulin signaling pathway
Prolactin signaling pathway
Type II diabetes mellitus

UniProtKB/Swiss-Prot: SOCS2_HUMAN, O14508
Pathway: Protein modification; protein ubiquitination


SOCS2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SOCS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/69 Interacting proteins for SOCS2 (O145081, 2, 3 ENSP000003394284) via UniProtKB, MINT, STRING, and/or I2D (see all 69)

InteractantInteraction Details
GeneCardExternal ID(s)
GHRP109122, 3, ENSP000002308824MINT-8028464 I2D: score=4 STRING: ENSP00000230882
EPORP192351, 2, 3, ENSP000002221394EBI-617737,EBI-617321 MINT-8037163 I2D: score=4 STRING: ENSP00000222139
TCEB1Q153692, 3, ENSP000002848114MINT-2835885 I2D: score=3 STRING: ENSP00000284811
IGF1RP080693, ENSP000002680354I2D: score=3 STRING: ENSP00000268035
SOCS1O155243, ENSP000003294184I2D: score=2 STRING: ENSP00000329418
About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001558regulation of cell growth NAS9727029
GO:0007259JAK-STAT cascade TAS9266833
GO:0007568aging IEA--
GO:0009966regulation of signal transduction NAS9727029
GO:0009968negative regulation of signal transduction IEA--

SOCS2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SOCS2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SOCS2

5 Novoseek inferred chemical compound relationships for SOCS2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine 46.2 6 10585430 (2), 10491180 (1), 16033816 (1), 12734778 (1) (see all 5)
ifn-alpha 43.2 3 16623280 (1), 11340296 (1)
imatinib 27.2 5 11861294 (5)
phosphatidylinositol 20.2 4 18165436 (1), 11279166 (1), 15644415 (1), 12396724 (1)
estrogen 0 10 15319356 (4), 12552091 (2), 17272397 (2)

Search CenterWatch for drugs/clinical trials and news about SOCS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SOCS2 gene (6 alternative transcripts): 
NM_001270467.1  NM_001270468.1  NM_001270469.1  NM_001270470.1  NM_001270471.1  NM_003877.4  

Unigene Clusters for SOCS2:

Suppressor of cytokine signaling 2
Hs.485572  [show with all ESTs], Hs.737206  [show with all ESTs]
Unigene Representative Sequences: NM_001270467, NM_001270470
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000340600(uc001tcw.1) ENST00000549206 ENST00000536696 ENST00000548091
ENST00000549122(uc021rbx.1 uc001tcy.1) ENST00000548537(uc001tcz.3)
ENST00000549887 ENST00000551556 ENST00000547229 ENST00000551883 ENST00000549510

Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SOCS2 (see all 24):
hsa-miR-448 hsa-miR-4311 hsa-miR-767-5p hsa-miR-139-5p hsa-miR-578 hsa-miR-507 hsa-miR-374c hsa-miR-511
SwitchGear 3'UTR luciferase reporter plasmidSOCS2 3' UTR sequence
Inhib. RNA
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS2
Sirion Biotech Customized lentivirus for stable overexpression of SOCS2 
                     Customized lentivirus expression plasmids for stable overexpression of SOCS2 
Primer
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OriGene qPCR primer pairs and template standards for SOCS2
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOCS2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOCS2

Additional mRNA sequence: AK309452.1 

12 DOTS entries:

DT.101956172  DT.317276  DT.121126609  DT.121126596  DT.100036041  DT.100790470  DT.95174534  DT.40121601 
DT.92072016  DT.91691821  DT.100790469  DT.121126598 

24/217 AceView cDNA sequences (see all 217):

AA983826 AI129818 BE047696 AI086984 AI863782 AI565994 AI265932 BQ025748 
BM839219 BG531237 BI335340 BU158967 AW157746 AI417033 BF848332 AI863402 
CB139464 CB215810 AA676519 AI223851 CB138041 AI147628 AA513372 AI246470 

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SOCS2 (see all 10)    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10
SP1:        -     -     -     -     -     -     -     -                 -                                                   
SP2:              -     -     -     -     -     -     -                 -                                                   
SP3:                    -     -     -     -     -     -                 -                                                   
SP4:                          -     -     -     -     -                 -                                                   
SP5:                                      -     -     -                 -                                                   


ECgene alternative splicing isoforms for SOCS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SOCS2 expression in normal human tissues (normalized intensities)      SOCS2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACATAAACA
SOCS2 Expression
About this image


SOCS2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/14 selected tissues (see all 14) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 4 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
 
 Thymus (Hematopoietic System)    fully expand to see all 3 entries
         T Helper Cells Thymus
 
 Fibroblast (Uncategorized)    fully expand to see all 2 entries
         Human Gingival Fibroblasts (HGF)   
 
 Neural Crest (Gastrulation Derivatives)
         PureStem MEL2, NCr-fac Progenitor
 
 Tendon & Ligament
         Human periodontal ligament Fibroblasts (HPLF)   

See SOCS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SOCS2

SOURCE GeneReport for Unigene clusters: Hs.485572 Hs.737206

UniProtKB/Swiss-Prot: SOCS2_HUMAN, O14508
Tissue specificity: High expression in heart, placenta, lung, kidney and prostate

    SABiosciences Expression via Pathway-Focused PCR Arrays including SOCS2: 
          Apoptosis 384HT in human mouse rat
          JAK / STAT Signaling Pathway in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Ubiquitin Ligases in human mouse rat

Primer
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OriGene qPCR primer pairs and template standards for SOCS2
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SOCS2 gene from 7/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Socs21 , 5 suppressor of cytokine signaling 21, 5 90.91(n)1
93.94(a)1
  10 (49.35 cM)5
2162331  NM_001168655.11  NP_001162126.11 
 953853625 
chicken
(Gallus gallus)
Aves SOCS21 suppressor of cytokine signaling 2 72.71(n)
81.21(a)
  395219  NM_204540.1  NP_989871.1 
lizard
(Anolis carolinensis)
Reptilia SOCS26
Uncharacterized protein
69(a)
1 ↔ 1
5(31408022-31412753)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.43102 Transcribed sequence with weak similarity to protein more 79.7(n)    AL850212.2 
zebrafish
(Danio rerio)
Actinopterygii socs21 suppressor of cytokine signaling 2 57.89(n)
57.37(a)
  562062  NM_001114550.1  NP_001108022.1 
fruit fly
(Drosophila melanogaster)
Insecta Socs44A6
Suppressor of Cytokine Signaling at 44A
14(a)
1 → many
2R(4015136-4016981)
worm
(Caenorhabditis elegans)
Secernentea F39B2.56
Protein F39B2.5
22(a)
1 → many
I(14775183-14776665)


ENSEMBL Gene Tree for SOCS2 (if available)
TreeFam Gene Tree for SOCS2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SOCS2 gene
SOCS32  SOCS42  SOCS52  SOCS72  SOCS12  SOCS62  CISH2  
4 SIMAP similar genes for SOCS2 using alignment to 5 protein entries:     SOCS2_HUMAN (see all proteins):
CISH    SOCS6    SOCS7    SOCS1

SOCS2 for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for SOCS2
PGOHUM00000261326 PGOHUM00000246268 PGOHUM00000246609


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/108 SNPs in SOCS2 are shown (see all 108)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1161702791,2
F--91031082(+) GGCGCC/TGCTTA 1 -- us2k11Minor allele frequency- T:0.10WA 118
rs415107441,2
C--91031173(+) GACGAC/GCACGG 1 -- us2k10--------
rs1886472241,2
--93967640(+) GGGGTA/GGGGGG 6 -- int10--------
rs1379040571,2
--93967645(+) GGGGGC/GAGCAC 6 -- int10--------
rs414155441,2
C--93967724(+) TGGTGC/TAGGCA 6 -- int10--------
rs37824151,2
C,F,A,H--93967755(-) CATCCA/GTCTCC 6 -- int124Minor allele frequency- G:0.31EA MN NS NA WA 4218
rs414654481,2
C,F--93967760(+) TGGATG/AGTTGT 6 -- int12Minor allele frequency- A:0.04WA 120
rs1430932091,2
--93967783(+) ATTAGA/GGCAAA 6 -- int10--------
rs1927857151,2
--93967850(+) TTCCCA/CTTTCT 6 -- int10--------
rs13894991,2
C,H--93967943(-) ATGTAG/AAAAGC 6 -- int11Minor allele frequency- A:0.00NS 112

HapMap Linkage Disequilibrium report for SOCS2 (93963590 - 93977263 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for SOCS2:    About this table     
Variant IDTypeSubtypePubMed ID
esv25615CNV Loss19812545
nsv7234OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605117    OMIM disorders: --

20/32 diseases for SOCS2 (see all 32):    About MalaCards
placental insufficiency    gigantism    polycythemia    essential thrombocythemia
idiopathic short stature    vogt-koyanagi-harada disease    chronic myeloid leukemia    polycythemia vera
myeloid leukemia    atopy    bronchiolitis    short stature
acute myeloid leukemia    chronic lymphocytic leukemia    meningioma    hepatitis c
renal cell carcinoma    systemic lupus erythematosus    melanoma    lupus erythematosus


SOCS2 for disorders           About GeneDecksing

10 Novoseek inferred disease relationships for SOCS2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia 23.7 2 9266833 (1), 10969179 (1)
myeloid leukemia chronic 5.96 1 11861294 (1)
inflammation 3.48 1 16623280 (1)
renal failure chronic 0 1 15723195 (1)
necrosis 0 1 15491991 (1)
breast cancer 0 6 17651480 (3), 17272397 (2), 16189149 (1)
tumors 0 9 15491991 (1), 16410303 (1), 16707422 (1), 16374457 (1) (see all 7)
carcinoma 0 1 17651480 (1)
melanoma 0 4 16374457 (3), 18627528 (1)
cancer 0 2 16125365 (1), 17001312 (1)

Genetic Association Database (GAD): SOCS2
Human Genome Epidemiology (HuGE) Navigator: SOCS2 (17 documents)

Export disorders for SOCS2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SOCS2 gene, integrated from 9 sources (see all 161):
(articles sorted by number of sources associating them with SOCS2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PubMed id 9266833)1, 2, 3, 9 Minamoto S.... Kishimoto T. (1997)
  2. Cloning and characterization of novel CIS family genes. (PubMed id 9344848)1, 2, 3 Masuhara M.... Yoshimura A. (1997)
  3. Association of single-nucleotide polymorphisms in the suppressor of cytokine signaling 2 (SOCS2) gene with type 2 diabetes in the Japanese. (PubMed id 16406727)1, 4, 9 Kato H....Itakura M. (2006)
  4. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
  5. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
  6. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
  7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  8. A multiplex MALDI-TOF MS approach facilitates genotyp ing of DNA from formalin-fixed paraffin-embedded tumour specimens. (PubMed id 20802378)1, 4 Horn H....Schaeffeler E. (2010)
  9. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
  10. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
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OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8835 HGNC: 19382 AceView: SOCS2 Ensembl:ENSG00000120833 euGenes: HUgn8835
ECgene: SOCS2 Kegg: 8835 H-InvDB: SOCS2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SOCS2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SOCS2 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SOCS2 gene:
Search GeneIP for patents involving SOCS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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