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Aliases for SOCS1 Gene

Aliases for SOCS1 Gene

  • Suppressor Of Cytokine Signaling 1 2 3 5
  • STAT-Induced STAT Inhibitor 1 3 4
  • Tec-Interacting Protein 3 3 4
  • SOCS-1 3 4
  • SSI-1 3 4
  • TIP-3 3 4
  • SSI1 3 4
  • TIP3 3 4
  • JAB 3 4
  • Cytokine-Inducible SH2 Protein 1 3
  • STAT Induced SH3 Protein 1 3
  • JAK Binding Protein 3
  • JAK-Binding Protein 4
  • CISH1 3
  • CIS1 3

External Ids for SOCS1 Gene

Previous GeneCards Identifiers for SOCS1 Gene

  • GC16M011499
  • GC16M011314

Summaries for SOCS1 Gene

Entrez Gene Summary for SOCS1 Gene

  • This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOCS1 Gene

SOCS1 (Suppressor Of Cytokine Signaling 1) is a Protein Coding gene. Diseases associated with SOCS1 include Infectious Anterior Uveitis and Ileum Cancer. Among its related pathways are Interferon gamma signaling and IL-2 Pathway. GO annotations related to this gene include protein kinase binding and insulin-like growth factor receptor binding. An important paralog of this gene is SOCS3.

UniProtKB/Swiss-Prot for SOCS1 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Gene Wiki entry for SOCS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS1 Gene

Genomics for SOCS1 Gene

Regulatory Elements for SOCS1 Gene

Enhancers for SOCS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F011231 1.7 FANTOM5 Ensembl ENCODE 24.6 +21.9 21929 5.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A CBX5 ZNF143 FOS KLF13 JUNB SOCS1 RMI2 ENSG00000199668 PRM3 ENSG00000212228 TNP2 HNRNPCP4 LOC105371083 NUBP1 CIITA
GH16F011200 1.7 FANTOM5 Ensembl ENCODE 21 +54.1 54133 2.9 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 FOS KLF13 MXD4 REST SOCS1 NUBP1 LOC105371084 HNRNPCP4 ENSG00000261560 RMI2 COX6CP1 ENSG00000261216 ENSG00000199668 TNP2
GH16F011098 1.7 FANTOM5 Ensembl ENCODE 20.1 +153.5 153480 8.6 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B YY1 FOS KLF13 JUNB SOCS1 NUBP1 LOC105371084 ENSG00000261560 COX6CP1 HNRNPCP4 ENSG00000261216 RMI2 RSL1D1 TNP2
GH16F011325 1.6 FANTOM5 Ensembl ENCODE 20.2 -71.8 -71809 5.8 HDGF PKNOX1 SIN3A ETS1 ZNF121 ZNF143 FOS JUNB REST TBX21 RMI2 SOCS1 LOC105371083 CIITA LITAF ZC3H7A TXNDC11 SNN ENSG00000199668
GH16F011258 1.2 FANTOM5 ENCODE 22.9 -2.8 -2766 1.2 PKNOX1 SIN3A ARID4B THRB ZNF48 RAD21 RARA YY1 ZNF121 ETV6 RMI2 SOCS1 ENSG00000199668 CIITA LITAF SNN TNP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SOCS1 on UCSC Golden Path with GeneCards custom track

Promoters for SOCS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001799552 382 2801 HDGF CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143
ENSR00000270710 -1318 201 HDGF ARID4B ZNF48 ZNF2 ZNF143 REST SMARCB1 SSRP1 SMARCA4 MYNN

Genomic Location for SOCS1 Gene

Chromosome:
16
Start:
11,254,405 bp from pter
End:
11,256,182 bp from pter
Size:
1,778 bases
Orientation:
Minus strand

Genomic View for SOCS1 Gene

Genes around SOCS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOCS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOCS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS1 Gene

Proteins for SOCS1 Gene

  • Protein details for SOCS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15524-SOCS1_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 1
    Protein Accession:
    O15524
    Secondary Accessions:
    • O15097
    • Q9NSA7

    Protein attributes for SOCS1 Gene

    Size:
    211 amino acids
    Molecular mass:
    23551 Da
    Quaternary structure:
    • Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1 (By similarity). Interacts (via SH2 domain and SOCS box) with TRIM8 (By similarity). Interacts with AXL, CUL2 and FGFR3. Interacts with INSR (By similarity).

neXtProt entry for SOCS1 Gene

Post-translational modifications for SOCS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOCS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOCS1 Gene

Domains & Families for SOCS1 Gene

Protein Domains for SOCS1 Gene

Graphical View of Domain Structure for InterPro Entry

O15524

UniProtKB/Swiss-Prot:

SOCS1_HUMAN :
  • The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
Domain:
  • The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity).
  • Contains 1 SH2 domain.
  • Contains 1 SOCS box domain.
genes like me logo Genes that share domains with SOCS1: view

Function for SOCS1 Gene

Molecular function for SOCS1 Gene

UniProtKB/Swiss-Prot Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
UniProtKB/Swiss-Prot Induction:
By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families.

Gene Ontology (GO) - Molecular Function for SOCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 9202125
GO:0005159 insulin-like growth factor receptor binding IPI 9727029
GO:0005515 protein binding IPI 16273093
GO:0019210 kinase inhibitor activity ISS --
GO:0019901 protein kinase binding IPI 9727029
genes like me logo Genes that share ontologies with SOCS1: view
genes like me logo Genes that share phenotypes with SOCS1: view

Animal Models for SOCS1 Gene

MGI Knock Outs for SOCS1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS1 Gene

Localization for SOCS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOCS1 Gene

Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOCS1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SOCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,TAS 9202126
GO:0005829 cytosol TAS --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SOCS1: view

Pathways & Interactions for SOCS1 Gene

genes like me logo Genes that share pathways with SOCS1: view

UniProtKB/Swiss-Prot O15524-SOCS1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SOCS1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for SOCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation ISS --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0007259 JAK-STAT cascade IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0010534 regulation of activation of JAK2 kinase activity IEA --
genes like me logo Genes that share ontologies with SOCS1: view

Drugs & Compounds for SOCS1 Gene

(6) Drugs for SOCS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for SOCS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SOCS1: view

Transcripts for SOCS1 Gene

mRNA/cDNA for SOCS1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(185) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOCS1 Gene

Suppressor of cytokine signaling 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS1 Gene

No ASD Table

Relevant External Links for SOCS1 Gene

GeneLoc Exon Structure for
SOCS1
ECgene alternative splicing isoforms for
SOCS1

Expression for SOCS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SOCS1 Gene

Protein differential expression in normal tissues from HIPED for SOCS1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SOCS1 Gene



Protein tissue co-expression partners for SOCS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SOCS1 Gene:

SOCS1

SOURCE GeneReport for Unigene cluster for SOCS1 Gene:

Hs.50640

mRNA Expression by UniProt/SwissProt for SOCS1 Gene:

O15524-SOCS1_HUMAN
Tissue specificity: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with SOCS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SOCS1 Gene

Orthologs for SOCS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SOCS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOCS1 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia SOCS1 34 35
  • 95.24 (n)
cow
(Bos Taurus)
Mammalia SOCS1 34 35
  • 94.15 (n)
rat
(Rattus norvegicus)
Mammalia Socs1 34
  • 88.63 (n)
mouse
(Mus musculus)
Mammalia Socs1 34 16 35
  • 88.47 (n)
oppossum
(Monodelphis domestica)
Mammalia SOCS1 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOCS1 35
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOCS1 34 35
  • 63.77 (n)
lizard
(Anolis carolinensis)
Reptilia SOCS1 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia socs1 34
  • 55.77 (n)
zebrafish
(Danio rerio)
Actinopterygii socs1a 35 34
  • 52.99 (n)
OneToMany
socs1b 35
  • 38 (a)
OneToMany
Species where no ortholog for SOCS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOCS1 Gene

ENSEMBL:
Gene Tree for SOCS1 (if available)
TreeFam:
Gene Tree for SOCS1 (if available)

Paralogs for SOCS1 Gene

Paralogs for SOCS1 Gene

(1) SIMAP similar genes for SOCS1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SOCS1: view

Variants for SOCS1 Gene

Sequence variations from dbSNP and Humsavar for SOCS1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11549428 untested 11,254,849(-) TTCCA(A/C/G)ATTTG intron-variant, reference, synonymous-codon, missense
rs587778690 untested 11,255,339(-) CCCGG(-/TCCCGG)CCCCG intron-variant, cds-indel
rs587778691 untested 11,255,330(-) GCCCC(-/GGCCCC)CGGCG intron-variant, cds-indel
rs587778692 untested 11,255,463(-) ACAAC(C/G)AGGTG intron-variant, reference, missense
rs587778693 untested 11,255,081(-) GGCCG(C/G)CCGCT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SOCS1 Gene

Variant ID Type Subtype PubMed ID
nsv827552 CNV gain 20364138
nsv571453 CNV loss 21841781
nsv525548 CNV loss 19592680
nsv1040428 CNV gain 25217958
esv23744 CNV loss 19812545

Variation tolerance for SOCS1 Gene

Gene Damage Index Score: 0.50; 10.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOCS1 Gene

Human Gene Mutation Database (HGMD)
SOCS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOCS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS1 Gene

Disorders for SOCS1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SOCS1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
infectious anterior uveitis
  • infectious secondary iridocyclitis
ileum cancer
  • ileal neoplasm
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
colorectal cancer
  • colorectal cancer, somatic
essential thrombocythemia
  • essential thrombocythaemia
- elite association - COSMIC cancer census association via MalaCards
Search SOCS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SOCS1

Genetic Association Database (GAD)
SOCS1
Human Genome Epidemiology (HuGE) Navigator
SOCS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOCS1
genes like me logo Genes that share disorders with SOCS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOCS1 Gene

Publications for SOCS1 Gene

  1. Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus. (PMID: 20064913) Chan H.C. … Yen J.H. (Lupus 2010) 3 22 46 64
  2. Functional SOCS1 polymorphisms are associated with variation in obesity in whites. (PMID: 19215277) Gylvin T. … Pociot F. (Diabetes Obes Metab 2009) 3 22 46 64
  3. Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. (PMID: 17099141) Harada M. … Tamari M. (Am. J. Respir. Cell Mol. Biol. 2007) 3 22 46 64
  4. Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. (PMID: 16410555) Ben-Zvi T. … Monsonego-Ornan E. (J. Cell Sci. 2006) 3 4 22 64
  5. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PMID: 9266833) Minamoto S. … Kishimoto T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 64

Products for SOCS1 Gene

Sources for SOCS1 Gene

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