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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SOCS1 Gene

protein-coding GIFtS: 66
GCID: GC16M011255

suppressor of cytokine signaling 1

Explore 90 diseases affiliated with
SOCS1 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Suppressor Of Cytokine Signaling 1¹ ²		STAT-Induced STAT Inhibitor 1² ³
JAB¹ ² ³		Tec-Interacting Protein 3² ³
SOCS-1¹ ² ³		CIS1² ⁵
SSI-1¹ ² ³		CISH1² ⁵
TIP3¹ ² ³		Cish1¹
SSI1² ³ ⁵		Cytokine-Inducible SH2 Protein 1²
TIP-3² ³		JAK Binding Protein²
JAK-Binding Protein² ³		STAT Induced SH3 Protein 1²

External Ids:	HGNC: 19383¹	Entrez Gene: 8651²	Ensembl: ENSG00000185338⁷	OMIM: 603597⁵	UniProtKB: O15524³

Export aliases for SOCS1 gene to outside databases

Previous GC identifers: GC16M011499 GC16M011314

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOCS1:

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling

(SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of

this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and

interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in

a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as

a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: SOCS1_HUMAN, O15524

Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal

transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through

binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to

be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates

interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS

(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent

proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R

signaling pathway

Gene Wiki entry for SOCS1 (Suppressor of cytokine signaling 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SOCS1 gene promoter:
CREB AP-1 deltaCREB ATF-2 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SOCS1 promoter sequence

Search SABiosciences Chromatin IP Primers for SOCS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOCS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.13 Ensembl cytogenetic band: 16p13.13 HGNC cytogenetic band: 16p13.13

SOCS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M011255: view genomic region (about GC identifiers)

Start:	11,348,262 bp from pter	End:	11,350,039 bp from pter
Size:	1,778 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SOCS1_HUMAN, O15524 (See protein sequence)

Recommended Name: Suppressor of cytokine signaling 1

Size: 211 amino acids; 23551 Da

Subunit: Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK

family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a

phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in

the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex

(TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5,

RBX1 and SOCS1 (By similarity). Interacts (via SH2 domain and SOCS box) with TRIM8 (By similarity). Interacts with

AXL, CUL2 and FGFR3. Interacts with INSR (By similarity)

Subcellular location: Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction

with FGFR3

Secondary accessions: O15097 Q9NSA7

Explore the universe of human proteins at neXtProt for SOCS1: NX_O15524

SOCS1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003736.1

ENSEMBL proteins:

ENSP00000329418

Reactome Protein details: O15524
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SOCS1 OriGene Protein Over-expression Lysate: SOCS1 OriGene Custom Protein Services for SOCS1
	GenScript Custom Purified and Recombinant Proteins Services for SOCS1
	Novus Biologicals SOCS1 Proteins Novus Biologicals SOCS1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SOCS1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	9202126
GO:0005829	cytosol	TAS	--
GO:0016023	cytoplasmic membrane-bounded vesicle	IEA	--

SOCS1 for ontologies About GeneDecksing

SOCS1 Antibody Products:

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	R&D Systems Antibodies for SOCS1 (SOCS-1)
	Cell Signaling Technology (CST) Antibodies for SOCS1
	OriGene Antibodies (see all 3): SOCS1 OriGene Custom Antibody Services for SOCS1
	GenScript Custom Superior Antibodies Services for SOCS1
	Novus Biologicals SOCS1 Antibodies
	Abcam antibodies for SOCS1
	Uscn Antibodies for SOCS1
	ThermoFisher Antibodies for SOCS1

Assay Products for SOCS1:

	EMD Millipore Kits and Assays for the Analysis of SOCS1
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SOCS1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SOCS1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SOCS1 for domains About GeneDecksing

2 InterPro domains/families:

IPR001496 SOCS_C

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry O15524

ProtoNet protein and cluster: O15524

1 Blocks protein family: IPB001496 SOCS protein

UniProtKB/Swiss-Prot: SOCS1_HUMAN, O15524

Domain: The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain

is necessary for signal and kinase inhibition

Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3

ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus

[APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity)

Similarity: Contains 1 SH2 domain

Similarity: Contains 1 SOCS box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SOCS1_HUMAN, O15524

Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal

transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through

binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to

be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates

interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS

(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent

proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R

signaling pathway

Induction: By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating

factor families

miRNA Products:		miRTarBase miRNAs that target SOCS1: hsa-mir-19b (MIRT004336), hsa-mir-19a (MIRT004337), hsa-mir-155 (MIRT000456)

		OriGene 3'-UTR Clone: SOCS1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOCS1
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate SOCS1 (see all 31):
		hsa-miR-411* hsa-miR-142-5p hsa-miR-30c hsa-miR-379* hsa-miR-331-3p hsa-miR-548v hsa-miR-30d hsa-miR-221

		SwitchGear 3'UTR luciferase reporter plasmid: SOCS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOCS1 (see all 7) OriGene shRNA RFP: SOCS1 OriGene siRNA: SOCS1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOCS1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SOCS1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOCS1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOCS1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOCS1 (NM_003745)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SOCS1
		Search LifeMap BioReagents cell lines for SOCS1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004860	protein kinase inhibitor activity	TAS	9202125
GO:0005159	insulin-like growth factor receptor binding	IPI	9727029
GO:0005515	protein binding	IPI	17183367
GO:0019210	kinase inhibitor activity	ISS	--
GO:0019901	protein kinase binding	IPI	9727029

SOCS1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for SOCS1:

Decreased nuclei size in G2M

Decreased telomerase activity

Increased cell death HMECs cel

Animal Models:
Mouse knock-outs for SOCS1: Socs1^tm2Wehi Socs1^tm1Kish Socs1^tm1Jni Socs1^tm3.1Wehi
15/18 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Socs1) (see all 18):

cardiovascular system	cellular	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	liver/biliary system
mortality/aging	muscle	normal	renal/urinary system	reproductive system

SOCS1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/37 super-pathways (see all 37) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Development Thrombopoetin signaling via JAK-STAT pathway

	Development_Thrombopoetin signaling via JAK-STAT pathway	1.00			Jak/Stat Pathway	0.29
	Development Thrombopoetin signaling via JAK-STAT pathway	1.00

Development_Prolactin receptor signaling

	Development_Prolactin receptor signaling	1.00			Prolactin Signaling Pathway	0.39
	Development Prolactin receptor signaling	1.00

Immune response_IFN gamma signaling pathway

	Immune response_IFN gamma signaling pathway	1.00			IFN-gamma pathway	0.43
	Immune response IFN gamma signaling pathway	1.00

Regulation of IFNA signaling

	Regulation of IFNA signaling	1.00			Immune response IFN alpha/beta signaling pathway	0.71
	Immune response_IFN alpha/beta signaling pathway	0.71

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for SOCS1 (see all 7)

	Immune response IFN gamma signaling pathway
	Immune response IFN alpha/beta signaling pathway
	Development EPO-induced Jak-STAT pathway
	Immune response IL-3 activation and signaling pathway
	Immune response IL-4 signaling pathway

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SOCS1 (see all 8)

	IL-9 Pathway
	Growth Hormone Signaling
	STAT3 Pathway
	IL-4 Pathway
	Prolactin Signaling

2 Cell Signaling Technology (CST) Pathways for SOCS1

	Lymphocyte Signaling
	Jak/Stat Pathway

5/7 GeneGo (Thomson Reuters) Pathways for SOCS1 (see all 7)

	Immune response IL-4 signaling pathway
	Development Prolactin receptor signaling
	Immune response IL-3 activation and signaling pathway
	Development EPO-induced Jak-STAT pathway
	Immune response IFN gamma signaling pathway

5/15 BioSystems Pathways for SOCS1 (see all 15)

	Type II interferon signaling (IFNG)
	EPO Receptor Signaling
	Adipogenesis
	EGFR1 Signaling Pathway
	Insulin Signaling

5/15 Reactome Pathways for SOCS1 (see all 15)

	Regulation of IFNA signaling
	Interferon alpha/beta signaling
	Interferon gamma signaling
	Cytokine Signaling in Immune system
	Polyubiquitination of substrate

5/6 Kegg Pathways (Kegg details for SOCS1) (see all 6):

	Ubiquitin mediated proteolysis
	Osteoclast differentiation
	Jak-STAT signaling pathway
	Insulin signaling pathway
	Type II diabetes mellitus

UniProtKB/Swiss-Prot: SOCS1_HUMAN, O15524

Pathway: Protein modification; protein ubiquitination

SOCS1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SOCS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/132 Interacting proteins for SOCS1 (O15524^{2, 3} ENSP00000329418⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 132)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TCEB2	Q15370²^,³, ENSP00000262306⁴	MINT-7014221 MINT-7014239 MINT-7014201 I2D: score=4 STRING: ENSP00000262306
COMMD1	Q8N668²^,³, ENSP00000308236⁴	MINT-4140906 MINT-4140761 MINT-4140776 I2D: score=3 STRING: ENSP00000308236
TUBA3C	Q13748²^,³, ENSP00000382982⁴	MINT-7014036 MINT-7014046 I2D: score=1 STRING: ENSP00000382982
ERBB2	P04626²^,³, ENSP00000269571⁴	MINT-74751 MINT-74750 I2D: score=2 STRING: ENSP00000269571
TUBA3D	Q13748²^,³	MINT-7014036 MINT-7014046 I2D: score=1

About this table

Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001932	regulation of protein phosphorylation	ISS	--
GO:0006469	negative regulation of protein kinase activity	TAS	9202125
GO:0007259	JAK-STAT cascade	TAS	9202126
GO:0016567	protein ubiquitination	IEA	--
GO:0019221	cytokine-mediated signaling pathway	TAS	--

SOCS1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SOCS1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SOCS1
10/12 Novoseek chemical compound relationships for SOCS1 gene (see all 12) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	57.8	54	10022833 (4), 10064597 (3), 10585430 (3), 15169905 (3) (see all 28)
gp 130	55.6	6	18684446 (3), 10777583 (1), 15771564 (1), 19620279 (1)
5-aza-2'deoxycytidine	47.1	7	17376806 (1), 15354212 (1), 12865927 (1), 12456503 (1) (see all 6)
ifn-alpha	36	3	18616672 (1), 11340296 (1)
poly(i-c)	29.4	1	16628196 (1)
phosphatidylinositol	4.32	1	12396724 (1)
nitric oxide	0	8	17059693 (5), 11342558 (1), 18282411 (1), 15899045 (1)
glucose	0	2	15169905 (1), 18801363 (1)
threonine	0	2	15561601 (1)
actinomycin d	0	1	10485906 (1)

Search CenterWatch for drugs/clinical trials and news about SOCS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SOCS1 gene:

NM_003745.1

Unigene Cluster for SOCS1:

Suppressor of cytokine signaling 1

Hs.50640 [show with all ESTs]

Unigene Representative Sequence: AK127621

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000332029(uc002dar.1)

miRNA Products:		OriGene 3'-UTR Clone: SOCS1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOCS1
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate SOCS1 (see all 31):
		hsa-miR-411* hsa-miR-142-5p hsa-miR-30c hsa-miR-379* hsa-miR-331-3p hsa-miR-548v hsa-miR-30d hsa-miR-221

		SwitchGear 3'UTR luciferase reporter plasmid: SOCS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOCS1 (see all 7) OriGene shRNA RFP: SOCS1 OriGene siRNA: SOCS1
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOCS1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOCS1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SOCS1 (NM_003745)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOCS1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SOCS1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOCS1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOCS1

Additional cDNA sequence:

AB000676.1 AB000734.1 AB005043.1 AK127621.1 U88326.1

4 DOTS entries:

DT.95224537 DT.95152705 DT.317446 DT.95224543

24/185 AceView cDNA sequences (see all 185):

BE046965 AI094927 AI057177 AI683421 AI990702 NM_003745 AI333398 AI298844

U88326 AB005043 AI313112 AI079449 N91127 CA950495 AI434761 AI951621

W24113 AW149450 AI671628 BQ187201 CK903906 AI955063 AK127621 AW025552

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SOCS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTACATATA

About this image
See SOCS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SOCS1

SOURCE GeneReport for Unigene cluster: Hs.50640

UniProtKB/Swiss-Prot: SOCS1_HUMAN, O15524

Tissue specificity: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood

leukocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including SOCS1 (see all 10):

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Th17 Response in human mouse rat

Leukemia in human mouse rat

Th1/Th2 Response in human mouse rat

Type I Interferon Response in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SOCS1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SOCS1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOCS1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOCS1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SOCS1 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SOCS1¹	suppressor of cytokine signaling 1	66.51(n) 66.67(a)		416630 NM_001137648.1 NP_001131120.1
lizard (Anolis carolinensis)	Reptilia	SOCS1⁶	--	61(a)	1 ↔ 1	AAWZ02038311(2140-2721)
zebrafish (Danio rerio)	Actinopterygii	socs1a¹	suppressor of cytokine signaling 1a	50(n) 42.93(a)		445073 NM_001003467.1 NP_001003467.1
honey bee (Apis mellifera)	Insecta	--	--	32(a)	1 → many	Group8.34(5736-6146)

ENSEMBL Gene Tree for SOCS1 (if available)
TreeFam Gene Tree for SOCS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SOCS1 gene

SOCS3² SOCS4² SOCS5² SOCS7² SOCS6² CISH² SOCS2²

1 SIMAP similar gene for SOCS1 using alignment to 2 protein entries: SOCS1_HUMAN (see all proteins):

SOCS2

SOCS1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72550812^1,2	F	--	11347848(-)	`TGCTTG/CAAATG`	1	--	ds500¹		5		MN	396
rs4780355^1,2	C,F,A,H,	--	11347858(+)	`AGATGC/TTTAGT`	1	--	ds500¹		31		EA NA NS MN WA CSA	2966
rs72550813^1,2	C,F,	--	11347869(-)	`TTTGGC/TTGTCC`	1	--	ds500¹		7		MN CSA WA	516
rs72550814^1,2	C,F,	--	11347894(-)	`GTCAAA/TGACAA`	1	--	ds500¹		7		MN WA	516
rs72550815^1,2	F	--	11347937(-)	`CTACAG/AAAGGG`	1	--	ds500¹		5		MN	396
rs144847656^1,2		--	11347969(+)	`CTCACA/GGGGTT`	1	--	ds500¹		0	--	--	--	--
rs183323217^1,2		--	11348036(+)	`TGGCAC/TGCACA`	1	--	ds500¹		0	--	--	--	--
rs148578384^1,2		--	11348037(+)	`GGCACA/GCACAA`	1	--	ds500¹		0	--	--	--	--
rs186494296^1,2		--	11348042(+)	`GCACAA/GAGTGC`	1	--	ds500¹		0	--	--	--	--
rs142963653^1,2		--	11348059(+)	`GCGAGC/TTGCTG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SOCS1 (11348262 - 11350039 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SOCS1
1 CNV: 72458
Human Gene Mutation Database (HGMD): SOCS1

5 SABiosciences Cancer Mutation PCR Assays for SOCS1:

Cosmic Id	AA Change
36138	p.Q210H
19319	p.P198S
19366	p.A37fs*27
19356	p.E152fs*58
19167	p.V117fs*93

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOCS1

DNA2.0 Custom Variant and Variant Library Synthesis for SOCS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SOCS1 for disorders           About GeneDecksing

OMIM gene information: 603597    OMIM disorders: --

20/90 diseases for SOCS1 (see all 90):    About MalaCards

vogt-koyanagi-harada disease monoclonal gammopathy of undetermined significance dengue hemorrhagic fever non-hodgkin lymphoma

type 2 diabetes mellitus hemorrhagic fever inflammatory bowel disease myeloid leukemia

myeloproliferative disorder b-cell lymphomas insulin resistance liver cirrhosis

multiple sclerosis hepatitis c neuroendocrine tumor esophageal squamous cell carcinoma

systemic lupus erythematosus squamous cell carcinoma lupus erythematosus hodgkin's lymphoma

10/54 Novoseek disease relationships for SOCS1 gene (see all 54) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
microsatellite instability	69.2	2	19470733 (1), 19789368 (1)
colorectal cancer	52.6	24	15793636 (3), 15074307 (3), 14719065 (2), 17339237 (1) (see all 11)
hepatocellular carcinoma	50.3	17	14614012 (2), 18639978 (2), 18606059 (2), 11322203 (1) (see all 13)
tumors	46.4	70	20164024 (4), 17376806 (3), 15373779 (3), 16532038 (3) (see all 42)
colon cancer	44.1	2	17898258 (1), 19551406 (1)
myeloproliferative disorders	40.6	5	18815196 (3), 17030374 (2)
leukemia	36.9	13	9811457 (2), 14616969 (2), 20372794 (1), 18684446 (1) (see all 10)
cancer	33.2	13	16644104 (1), 19342366 (1), 16125365 (1), 16426581 (1) (see all 12)
lymphoma b-cell	30.1	12	19734449 (4), 16287070 (2), 16598306 (1), 17867599 (1) (see all 5)
metastatic melanoma	26.9	2	19047140 (2)

Genetic Association Database (GAD): SOCS1
Human Genome Epidemiology (HuGE) Navigator: SOCS1 (31 documents)

Export disorders for SOCS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SOCS1 gene, integrated from 9 sources (see all 465):
(articles sorted by number of sources associating them with SOCS1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PubMed id 9266833)^{1, 2, 3} Minamoto S.... Kishimoto T. (1997)
Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. (PubMed id 16410555)^{1, 2, 9} Ben-Zvi T....Monsonego-Ornan E. (2006)
A family of cytokine-inducible inhibitors of signaling. (PubMed id 9202125)^{1, 2, 9} Starr R....Hilton D.J. (1997)
Cytokine signaling in the brain: putting a SOCS in it? (PubMed id 11835308)^{1, 2} Wang J. and Campbell I.L. (2002)
Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PubMed id 12470648)^{1, 2} Hafizi S.... Dahlbaeck B. (2002)
SOCS proteins: negative regulators of cytokine signaling. (PubMed id 11553846)^{1, 2} Krebs D.L. and Hilton D.J. (2001)
Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively. (PubMed id 10512686)^{1, 2} Yandava C.N.... Drazen J.M. (1999)
Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. (PubMed id 9727029)^{1, 2} Dey B.R.... Furlanetto R.W. (1998)
A new protein containing an SH2 domain that inhibits JAK kinases. (PubMed id 9202126)^{1, 2} Endo T.A.... Yoshimura A. (1997)
SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. (PubMed id 9341160)^{1, 2} Ohya K.... Mano H. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8651	HGNC: 19383	AceView: SOCS1	Ensembl:ENSG00000185338	euGenes: HUgn8651
ECgene: SOCS1	Kegg: 8651	H-InvDB: SOCS1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SOCS1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SOCS1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SOCS1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SOCS1 gene:
Search GeneIP for patents involving SOCS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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suppressor of cytokine signaling 1

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SOCS1 Gene

suppressor of cytokine signaling 1

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