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Aliases for SOCS1 Gene

Aliases for SOCS1 Gene

  • Suppressor Of Cytokine Signaling 1 2 3 5
  • STAT-Induced STAT Inhibitor 1 3 4
  • Tec-Interacting Protein 3 3 4
  • JAK-Binding Protein 3 4
  • SOCS-1 3 4
  • SSI-1 3 4
  • TIP-3 3 4
  • SSI1 3 4
  • TIP3 3 4
  • JAB 3 4
  • Cytokine-Inducible SH2 Protein 1 3
  • STAT Induced SH3 Protein 1 3
  • JAK Binding Protein 3
  • CISH1 3
  • CIS1 3

External Ids for SOCS1 Gene

Previous GeneCards Identifiers for SOCS1 Gene

  • GC16M011499
  • GC16M011314

Summaries for SOCS1 Gene

Entrez Gene Summary for SOCS1 Gene

  • This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOCS1 Gene

SOCS1 (Suppressor Of Cytokine Signaling 1) is a Protein Coding gene. Diseases associated with SOCS1 include Hodgkin Lymphoma and Hepatocellular Carcinoma. Among its related pathways are Development EPO-induced Jak-STAT pathway and Kit Receptor Signaling Pathway. GO annotations related to this gene include protein kinase binding and insulin-like growth factor receptor binding. An important paralog of this gene is SOCS7.

UniProtKB/Swiss-Prot for SOCS1 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Gene Wiki entry for SOCS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS1 Gene

Genomics for SOCS1 Gene

Regulatory Elements for SOCS1 Gene

Enhancers for SOCS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SOCS1 on UCSC Golden Path with GeneCards custom track

Promoters for SOCS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SOCS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SOCS1 Gene

Chromosome:
16
Start:
11,254,405 bp from pter
End:
11,256,182 bp from pter
Size:
1,778 bases
Orientation:
Minus strand

Genomic View for SOCS1 Gene

Genes around SOCS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOCS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOCS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS1 Gene

Proteins for SOCS1 Gene

  • Protein details for SOCS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15524-SOCS1_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 1
    Protein Accession:
    O15524
    Secondary Accessions:
    • O15097
    • Q9NSA7

    Protein attributes for SOCS1 Gene

    Size:
    211 amino acids
    Molecular mass:
    23551 Da
    Quaternary structure:
    • Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1 (By similarity). Interacts (via SH2 domain and SOCS box) with TRIM8 (By similarity). Interacts with AXL, CUL2 and FGFR3. Interacts with INSR (By similarity).

neXtProt entry for SOCS1 Gene

Proteomics data for SOCS1 Gene at MOPED

Post-translational modifications for SOCS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOCS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SOCS1 (SOCS1)

No data available for DME Specific Peptides for SOCS1 Gene

Domains & Families for SOCS1 Gene

Protein Domains for SOCS1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15524

UniProtKB/Swiss-Prot:

SOCS1_HUMAN :
  • The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
Domain:
  • The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity).
  • Contains 1 SH2 domain.
  • Contains 1 SOCS box domain.
genes like me logo Genes that share domains with SOCS1: view

Function for SOCS1 Gene

Molecular function for SOCS1 Gene

UniProtKB/Swiss-Prot Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
UniProtKB/Swiss-Prot Induction:
By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families.

Gene Ontology (GO) - Molecular Function for SOCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16273093
genes like me logo Genes that share ontologies with SOCS1: view
genes like me logo Genes that share phenotypes with SOCS1: view

Animal Models for SOCS1 Gene

MGI Knock Outs for SOCS1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS1 Gene

Localization for SOCS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOCS1 Gene

Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOCS1 Gene COMPARTMENTS Subcellular localization image for SOCS1 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2
mitochondrion 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SOCS1 Gene

Pathways & Interactions for SOCS1 Gene

genes like me logo Genes that share pathways with SOCS1: view

UniProtKB/Swiss-Prot O15524-SOCS1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SOCS1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for SOCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity TAS 9202125
GO:0010534 regulation of activation of JAK2 kinase activity IEA --
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway IEA,ISS --
GO:0031100 organ regeneration IEA --
genes like me logo Genes that share ontologies with SOCS1: view

Drugs & Compounds for SOCS1 Gene

(4) Drugs for SOCS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for SOCS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SOCS1: view

Transcripts for SOCS1 Gene

mRNA/cDNA for SOCS1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(185) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOCS1 Gene

Suppressor of cytokine signaling 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS1 Gene

No ASD Table

Relevant External Links for SOCS1 Gene

GeneLoc Exon Structure for
SOCS1
ECgene alternative splicing isoforms for
SOCS1

Expression for SOCS1 Gene

mRNA expression in normal human tissues for SOCS1 Gene

Protein differential expression in normal tissues from HIPED for SOCS1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SOCS1 Gene



SOURCE GeneReport for Unigene cluster for SOCS1 Gene Hs.50640

mRNA Expression by UniProt/SwissProt for SOCS1 Gene

O15524-SOCS1_HUMAN
Tissue specificity: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with SOCS1: view

Protein tissue co-expression partners for SOCS1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SOCS1 Gene

Orthologs for SOCS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SOCS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SOCS1 35
  • 94.15 (n)
  • 96.68 (a)
SOCS1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOCS1 35
  • 95.24 (n)
  • 97.52 (a)
SOCS1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Socs1 35
  • 88.47 (n)
  • 91.94 (a)
Socs1 16
Socs1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SOCS1 35
  • 99.21 (n)
  • 99.53 (a)
SOCS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Socs1 35
  • 88.63 (n)
  • 91.94 (a)
oppossum
(Monodelphis domestica)
Mammalia SOCS1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOCS1 36
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOCS1 35
  • 63.77 (n)
  • 62.32 (a)
SOCS1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOCS1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia socs1 35
  • 55.77 (n)
  • 58.29 (a)
zebrafish
(Danio rerio)
Actinopterygii socs1a 35
  • 52.99 (n)
  • 46.79 (a)
socs1a 36
  • 42 (a)
OneToMany
socs1b 36
  • 38 (a)
OneToMany
Species with no ortholog for SOCS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOCS1 Gene

ENSEMBL:
Gene Tree for SOCS1 (if available)
TreeFam:
Gene Tree for SOCS1 (if available)

Paralogs for SOCS1 Gene

Paralogs for SOCS1 Gene

(1) SIMAP similar genes for SOCS1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SOCS1: view

Variants for SOCS1 Gene

Sequence variations from dbSNP and Humsavar for SOCS1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_061808 -

Structural Variations from Database of Genomic Variants (DGV) for SOCS1 Gene

Variant ID Type Subtype PubMed ID
nsv525548 CNV Loss 19592680
nsv827552 CNV Gain 20364138
esv23744 CNV Loss 19812545

Variation tolerance for SOCS1 Gene

Gene Damage Index Score: 0.50; 10.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SOCS1 Gene

Human Gene Mutation Database (HGMD)
SOCS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS1 Gene

Disorders for SOCS1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SOCS1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hodgkin lymphoma
  • hodgkin's lymphoma
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
colorectal cancer
  • colorectal cancer, somatic
myelodysplastic syndrome
  • myelodysplastic syndrome, somatic
- elite association - COSMIC cancer census association via MalaCards
Search SOCS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SOCS1

Genetic Association Database (GAD)
SOCS1
Human Genome Epidemiology (HuGE) Navigator
SOCS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SOCS1
genes like me logo Genes that share disorders with SOCS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOCS1 Gene

Publications for SOCS1 Gene

  1. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PMID: 9266833) Minamoto S. … Kishimoto T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 67
  2. Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus. (PMID: 20064913) Chan H.C. … Yen J.H. (Lupus 2010) 3 23
  3. Enforced SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation. (PMID: 20372794) Cooper J.C. … Yu C.L. (Int. J. Oncol. 2010) 3 23
  4. Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells. (PMID: 20398276) Lesinski G.B. … Carson W.E. (BMC Cancer 2010) 3 23
  5. [SOCS1 knockdown sensitize anti-tumor activity of IFN-alpha2a-NGR]. (PMID: 20423643) Huang Q.C. … Yan Z. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010) 3 23

Products for SOCS1 Gene

Sources for SOCS1 Gene

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