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Aliases for SOCS1 Gene

Aliases for SOCS1 Gene

  • Suppressor Of Cytokine Signaling 1 2 3
  • SSI1 3 4 6
  • STAT-Induced STAT Inhibitor 1 3 4
  • Tec-Interacting Protein 3 3 4
  • JAK-Binding Protein 3 4
  • SOCS-1 3 4
  • CISH1 3 6
  • SSI-1 3 4
  • TIP-3 3 4
  • CIS1 3 6
  • TIP3 3 4
  • JAB 3 4
  • Cytokine-Inducible SH2 Protein 1 3
  • STAT Induced SH3 Protein 1 3
  • JAK Binding Protein 3

External Ids for SOCS1 Gene

Previous GeneCards Identifiers for SOCS1 Gene

  • GC16M011499
  • GC16M011314

Summaries for SOCS1 Gene

Entrez Gene Summary for SOCS1 Gene

  • This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOCS1 Gene

SOCS1 (Suppressor Of Cytokine Signaling 1) is a Protein Coding gene. Diseases associated with SOCS1 include silent pituitary adenoma and hepatocellular carcinoma. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include protein kinase binding and insulin-like growth factor receptor binding. An important paralog of this gene is SOCS2.

UniProtKB/Swiss-Prot for SOCS1 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Gene Wiki entry for SOCS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS1 Gene

Genomics for SOCS1 Gene

Regulatory Elements for SOCS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SOCS1 Gene

Start:
11,254,405 bp from pter
End:
11,256,182 bp from pter
Size:
1,778 bases
Orientation:
Minus strand

Genomic View for SOCS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOCS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS1 Gene

Proteins for SOCS1 Gene

  • Protein details for SOCS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15524-SOCS1_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 1
    Protein Accession:
    O15524
    Secondary Accessions:
    • O15097
    • Q9NSA7

    Protein attributes for SOCS1 Gene

    Size:
    211 amino acids
    Molecular mass:
    23551 Da
    Quaternary structure:
    • Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1 (By similarity). Interacts (via SH2 domain and SOCS box) with TRIM8 (By similarity). Interacts with AXL, CUL2 and FGFR3. Interacts with INSR (By similarity).

neXtProt entry for SOCS1 Gene

Proteomics data for SOCS1 Gene at MOPED

Post-translational modifications for SOCS1 Gene

No Post-translational modifications

Other Protein References for SOCS1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SOCS1 (SOCS1)

No data available for DME Specific Peptides for SOCS1 Gene

Domains for SOCS1 Gene

Gene Families for SOCS1 Gene

HGNC:
  • SH2D :SH2 domain containing
  • SOCS :Suppressors of cytokine signaling

Protein Domains for SOCS1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SOCS1 Gene

Graphical View of Domain Structure for InterPro Entry

O15524

UniProtKB/Swiss-Prot:

SOCS1_HUMAN :
  • O15524
Domain:
  • The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity).
  • Contains 1 SH2 domain.
  • Contains 1 SOCS box domain.
genes like me logo Genes that share domains with SOCS1: view

Function for SOCS1 Gene

Molecular function for SOCS1 Gene

UniProtKB/Swiss-Prot Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
UniProtKB/Swiss-Prot Induction: By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families

Gene Ontology (GO) - Molecular Function for SOCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 9202125
GO:0005159 insulin-like growth factor receptor binding IPI 9727029
GO:0005515 protein binding IPI 16273093
GO:0019210 kinase inhibitor activity ISS --
GO:0019901 protein kinase binding IPI 9727029
genes like me logo Genes that share ontologies with SOCS1: view
genes like me logo Genes that share phenotypes with SOCS1: view

Animal Models for SOCS1 Gene

MGI Knock Outs for SOCS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOCS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SOCS1 Gene

Localization for SOCS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOCS1 Gene

Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOCS1 Gene COMPARTMENTS Subcellular localization image for SOCS1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SOCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 9202126
GO:0005829 cytosol TAS --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with SOCS1: view

Pathways for SOCS1 Gene

genes like me logo Genes that share pathways with SOCS1: view

PCR Array Products

UniProtKB/Swiss-Prot O15524-SOCS1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SOCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation ISS --
GO:0006469 negative regulation of protein kinase activity TAS 9202125
GO:0007259 JAK-STAT cascade TAS 9202126
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with SOCS1: view

Compounds for SOCS1 Gene

(12) Novoseek inferred chemical compound relationships for SOCS1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 57.8 41
gp 130 55.6 6
5-aza-2deoxycytidine 47.1 6
ifn-alpha 36 2
poly(i-c) 29.4 1
genes like me logo Genes that share compounds with SOCS1: view

Transcripts for SOCS1 Gene

mRNA/cDNA for SOCS1 Gene

(185) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOCS1 Gene

Suppressor of cytokine signaling 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOCS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS1 Gene

No ASD Table

Relevant External Links for SOCS1 Gene

GeneLoc Exon Structure for
SOCS1
ECgene alternative splicing isoforms for
SOCS1

Expression for SOCS1 Gene

mRNA expression in normal human tissues for SOCS1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SOCS1 Gene

SOURCE GeneReport for Unigene cluster for SOCS1 Gene Hs.50640

mRNA Expression by UniProt/SwissProt for SOCS1 Gene

O15524-SOCS1_HUMAN
Tissue specificity: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes
genes like me logo Genes that share expressions with SOCS1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SOCS1 Gene

Orthologs for SOCS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SOCS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOCS1 35
  • 99.21 (n)
  • 99.53 (a)
SOCS1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SOCS1 35
  • 94.15 (n)
  • 96.68 (a)
SOCS1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOCS1 35
  • 95.24 (n)
  • 97.52 (a)
SOCS1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Socs1 35
  • 88.47 (n)
  • 91.94 (a)
Socs1 16
Socs1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SOCS1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOCS1 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Socs1 35
  • 88.63 (n)
  • 91.94 (a)
chicken
(Gallus gallus)
Aves SOCS1 35
  • 63.77 (n)
  • 62.32 (a)
SOCS1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOCS1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia socs1 35
  • 55.77 (n)
  • 58.29 (a)
zebrafish
(Danio rerio)
Actinopterygii socs1a 35
  • 52.99 (n)
  • 46.79 (a)
socs1a 36
  • 42 (a)
OneToMany
socs1b 36
  • 38 (a)
OneToMany
Species with no ortholog for SOCS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOCS1 Gene

ENSEMBL:
Gene Tree for SOCS1 (if available)
TreeFam:
Gene Tree for SOCS1 (if available)

Paralogs for SOCS1 Gene

Paralogs for SOCS1 Gene

Selected SIMAP similar genes for SOCS1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SOCS1: view

Variants for SOCS1 Gene

Sequence variations from dbSNP and Humsavar for SOCS1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs27829 -- 11,255,546(+) CAAAG(A/C/G/T)GGTGA intron-variant
rs27830 -- 11,255,990(+) CCCAT(C/T)CTGCA intron-variant
rs27831 -- 11,256,202(+) CTCTG(C/T)TCGGC upstream-variant-2KB
rs171472 -- 11,257,018(+) AAGGC(C/G)AGATC upstream-variant-2KB
rs193777 -- 11,257,532(+) ACGAT(A/G)CCTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SOCS1 Gene

Variant ID Type Subtype PubMed ID
nsv525548 CNV Loss 19592680
nsv827552 CNV Gain 20364138
esv23744 CNV Loss 19812545

Relevant External Links for SOCS1 Gene

HapMap Linkage Disequilibrium report
SOCS1
Human Gene Mutation Database (HGMD)
SOCS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS1 Gene

Disorders for SOCS1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for SOCS1 Gene including...

Search for SOCS1 Gene in MalaCards »

(54) Novoseek inferred disease relationships for SOCS1 Gene

Disease -log(P) Hits PubMed IDs
microsatellite instability 69.2 2
colorectal cancer 52.6 16
hepatocellular carcinoma 50.3 16
tumors 46.4 58
colon cancer 44.1 2

Relevant External Links for SOCS1

Genetic Association Database (GAD)
SOCS1
Human Genome Epidemiology (HuGE) Navigator
SOCS1
genes like me logo Genes that share disorders with SOCS1: view

No data available for UniProtKB/Swiss-Prot for SOCS1 Gene

Publications for SOCS1 Gene

  1. Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. (PMID: 16410555) Ben-Zvi T. … Monsonego-Ornan E. (J. Cell Sci. 2006) 3 4 23
  2. Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. (PMID: 17099141) Harada M. … Tamari M. (Am. J. Respir. Cell Mol. Biol. 2007) 3 23 48
  3. Functional SOCS1 polymorphisms are associated with variation in obesity in whites. (PMID: 19215277) Gylvin T. … Pociot F. (Diabetes Obes Metab 2009) 3 23 48
  4. Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus. (PMID: 20064913) Chan H.C. … Yen J.H. (Lupus 2010) 3 23 48
  5. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PMID: 9266833) Minamoto S. … Kishimoto T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4

Products for SOCS1 Gene

Sources for SOCS1 Gene

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