Aliases for SOCS1 Gene
External Ids for SOCS1 Gene
Previous GeneCards Identifiers for SOCS1 Gene
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOCS1 Gene
SOCS1 (Suppressor Of Cytokine Signaling 1) is a Protein Coding gene. Diseases associated with SOCS1 include Infectious Anterior Uveitis and Primary Biliary Cholangitis. Among its related pathways are Activated TLR4 signalling and Type II interferon signaling (IFNG). GO annotations related to this gene include protein kinase binding and insulin-like growth factor receptor binding. An important paralog of this gene is CISH.
UniProtKB/Swiss-Prot for SOCS1 Gene
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.