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SOCS1 Gene

protein-coding   GIFtS: 65
GCID: GC16M011255

Suppressor Of Cytokine Signaling 1

  See SOCS1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Cytokine Signaling 11 2     STAT-Induced STAT Inhibitor 12 3
SSI12 3 5     Tec-Interacting Protein 32 3
JAB2 3     CIS12 5
SOCS-12 3     CISH12 5
SSI-12 3     Cytokine-Inducible SH2 Protein 12
TIP-32 3     JAK Binding Protein2
TIP32 3     STAT Induced SH3 Protein 12
JAK-Binding Protein2 3     

External Ids:    HGNC: 193831   Entrez Gene: 86512   Ensembl: ENSG000001853387   OMIM: 6035975   UniProtKB: O155243   

Export aliases for SOCS1 gene to outside databases

Previous GC identifers: GC16M011499 GC16M011314


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOCS1 Gene:
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine
signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.
The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO),
CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine
receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice
suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth
and survival. (provided by RefSeq, Jul 2008)

GeneCards Summary for SOCS1 Gene:
SOCS1 (suppressor of cytokine signaling 1) is a protein-coding gene. Diseases associated with SOCS1 include silent pituitary adenoma, and hepatocellular carcinoma. GO annotations related to this gene include insulin-like growth factor receptor binding and protein kinase binding. An important paralog of this gene is SOCS3.

UniProtKB/Swiss-Prot: SOCS1_HUMAN, O15524
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway.
Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity.
Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF).
Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition
component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the
ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears
to be a negative regulator in IGF1R signaling pathway

Gene Wiki entry for SOCS1 (Suppressor of cytokine signaling 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOCS1 gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSOCS1 promoter sequence
   Search Chromatin IP Primers for SOCS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOCS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.13   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13.13

SOCS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOCS1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M011255:  view genomic region     (about GC identifiers)

Start:
11,348,262 bp from pter      End:
11,350,039 bp from pter
Size:
1,778 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SOCS1_HUMAN, O15524 (See protein sequence)
Recommended Name: Suppressor of cytokine signaling 1  
Size: 211 amino acids; 23551 Da
Subunit: Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including
JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a
phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline
determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the
Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which
contains Elongin BC, CUL5, RBX1 and SOCS1 (By similarity). Interacts (via SH2 domain and SOCS box) with TRIM8 (By
similarity). Interacts with AXL, CUL2 and FGFR3. Interacts with INSR (By similarity)
Secondary accessions: O15097 Q9NSA7

Explore the universe of human proteins at neXtProt for SOCS1: NX_O15524

Explore proteomics data for SOCS1 at MOPED


See SOCS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003736.1  
ENSEMBL proteins: 
 ENSP00000329418  
Reactome Protein details: O15524

SOCS1 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SOCS: Suppressors of cytokine signaling
SH2D: SH2 domain containing

4 InterPro protein domains:
 IPR001496 SOCS_C
 IPR000980 SH2
 IPR028411 SOCS1
 IPR028413 SOCS

Graphical View of Domain Structure for InterPro Entry O15524

ProtoNet protein and cluster: O15524

1 Blocks protein domain: IPB001496 SOCS protein

UniProtKB/Swiss-Prot: SOCS1_HUMAN, O15524
Domain: The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR
domain is necessary for signal and kinase inhibition
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus
[APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity)
Similarity: Contains 1 SH2 domain
Similarity: Contains 1 SOCS box domain


Find genes that share domains with SOCS1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SOCS1_HUMAN, O15524
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal
transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway.
Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity.
Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF).
Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition
component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the
ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears
to be a negative regulator in IGF1R signaling pathway
Induction: By a subset of cytokines including those belonging to the interferon, interleukin and
colony-stimulating factor families

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004860protein kinase inhibitor activity TAS9202125
GO:0005159insulin-like growth factor receptor binding IPI9727029
GO:0005515protein binding IPI16273093
GO:0019210kinase inhibitor activity ISS--
GO:0019901protein kinase binding IPI9727029
     
Find genes that share ontologies with SOCS1           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for SOCS1:
 Decreased nuclei size in G2M  Decreased telomerase activity  Increased cell death HMECs cel 

     Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Socs1) (see all 17):
 cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system 
 homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
 muscle  normal  renal/urinary system  reproductive system  respiratory system 

Find genes that share phenotypes with SOCS1           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for SOCS1: Socs1tm2Wehi Socs1tm1Jni Socs1tm1Kish Socs1tm3.1Wehi

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOCS1
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOCS1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOCS1

miRNA
Products:
    
miRTarBase miRNAs that target SOCS1:
hsa-mir-19b-3p (MIRT004336), hsa-mir-19a-3p (MIRT004337), hsa-mir-155-5p (MIRT000456), hsa-mir-30c-5p (MIRT007132), hsa-let-7i-5p (MIRT006373), hsa-mir-30b-5p (MIRT006325), hsa-mir-122-5p (MIRT007084)

Block miRNA regulation of human, mouse, rat SOCS1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SOCS1 (see all 31):
hsa-miR-411* hsa-miR-142-5p hsa-miR-30c hsa-miR-379* hsa-miR-331-3p hsa-miR-548v hsa-miR-30d hsa-miR-221
SwitchGear 3'UTR luciferase reporter plasmidSOCS1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for SOCS1
Predesigned siRNA for gene silencing in human, mouse, rat SOCS1

Gene Editing
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OriGene ORF clones in mouse, rat for SOCS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SOCS1 (NM_003745)
Sino Biological Human cDNA Clone for SOCS1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS1

Cell Line
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GenScript Custom overexpressing Cell Line Services for SOCS1
Browse ESI BIO Cell Lines and PureStem Progenitors for SOCS1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SOCS1_HUMAN, O15524: Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon
interaction with FGFR3
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol4
plasma membrane1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005737cytoplasm TAS9202126
GO:0005829cytosol TAS--
GO:0016023cytoplasmic membrane-bounded vesicle IEA--

Find genes that share ontologies with SOCS1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SOCS1 About   (see all 34)  
See pathways by source

SuperPathContained pathways About
1Prolactin Signaling Pathway
Development Prolactin receptor signaling0.39
Prolactin signaling pathway0.33
Prolactin Signaling Pathway0.39
2Class I MHC mediated antigen processing and presentation
Class I MHC mediated antigen processing and presentation0.84
Adaptive Immune System0.41
Antigen processing- Ubiquitination and Proteasome degradation0.84
Ubiquitin mediated proteolysis0.35
3Immune response IFN alpha beta signaling pathway
Immune response IFN alpha beta signaling pathway0.69
Interferon alpha/beta signaling0.43
Regulation of IFNA signaling0.69
4Immune response IFN gamma signaling pathway
IFN-gamma pathway0.43
Immune response IFN gamma signaling pathway0.43
5Development EPO induced Jak STAT pathway
Development EPO induced Jak STAT pathway0.42
EPO Receptor Signaling0.42


Find genes that share SuperPaths with SOCS1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SOCS1 (see all 8)
    IL-9 Pathway
Growth Hormone Signaling
STAT3 Pathway
IL-4 Pathway
Prolactin Signaling

2 Cell Signaling Technology (CST) Pathways for SOCS1
    Lymphocyte Signaling
Jak/Stat Pathway

Selected GeneGo (Thomson Reuters) Pathways for SOCS1 (see all 7)
    Immune response IL-4 signaling pathway
Development Prolactin receptor signaling
Immune response IL-3 activation and signaling pathway
Development EPO-induced Jak-STAT pathway
Immune response IFN gamma signaling pathway

Selected BioSystems Pathways for SOCS1 (see all 15)
    EGFR1 Signaling Pathway
Adipogenesis
Insulin Signaling
EPO Receptor Signaling
Type II interferon signaling (IFNG)


Selected Reactome Pathways for SOCS1 (see all 6)
    Regulation of IFNA signaling
Interferon gamma signaling
Regulation of IFNG signaling
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of KIT signaling


Selected Kegg Pathways  (Kegg details for SOCS1) (see all 8):
    Ubiquitin mediated proteolysis
Osteoclast differentiation
Jak-STAT signaling pathway
Insulin signaling pathway
Prolactin signaling pathway

UniProtKB/Swiss-Prot: SOCS1_HUMAN, O15524
Pathway: Protein modification; protein ubiquitination

    Pathway & Disease-focused RT2 Profiler PCR Arrays including SOCS1 (see all 10): 

          G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
          Th17 Response in human mouse rat
          Leukemia in human mouse rat
          Th1/Th2 Response in human mouse rat
          Type I Interferon Response in human mouse rat

Interactions:

    GeneGlobe Interaction Network for SOCS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for SOCS1 (O155241, 2, 3 ENSP000003294184) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
InteractantInteraction Details
GeneCardExternal ID(s)
COMMD1Q8N6681, 2, 3, ENSP000003082364EBI-968198,EBI-1550112 MINT-4140906 MINT-4140761 MINT-4140776 I2D: score=3 STRING: ENSP00000308236
ERBB2P046261, 2, 3, ENSP000002695714EBI-968198,EBI-641062 MINT-74751 MINT-74750 I2D: score=2 STRING: ENSP00000269571
TCEB2Q153702, 3, ENSP000002623064MINT-7014221 MINT-7014239 MINT-7014201 I2D: score=4 STRING: ENSP00000262306
TUBA3CQ137482, 3, ENSP000003829824MINT-7014036 MINT-7014046 I2D: score=1 STRING: ENSP00000382982
TUBA3DQ137482, 3MINT-7014036 MINT-7014046 I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001932regulation of protein phosphorylation ISS--
GO:0006469negative regulation of protein kinase activity TAS9202125
GO:0007259JAK-STAT cascade TAS9202126
GO:0016567protein ubiquitination IEA--
GO:0019221cytokine-mediated signaling pathway TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SOCS1

Selected Novoseek inferred chemical compound relationships for SOCS1 gene (see all 12)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine 57.8 54 10022833 (4), 10064597 (3), 10585430 (3), 15169905 (3) (see all 28)
gp 130 55.6 6 18684446 (3), 10777583 (1), 15771564 (1), 19620279 (1)
5-aza-2'deoxycytidine 47.1 7 17376806 (1), 15354212 (1), 12865927 (1), 12456503 (1) (see all 6)
ifn-alpha 36 3 18616672 (1), 11340296 (1)
poly(i-c) 29.4 1 16628196 (1)
phosphatidylinositol 4.32 1 12396724 (1)
nitric oxide 0 8 17059693 (5), 11342558 (1), 18282411 (1), 15899045 (1)
glucose 0 2 15169905 (1), 18801363 (1)
threonine 0 2 15561601 (1)
actinomycin d 0 1 10485906 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SOCS1 gene: 
NM_003745.1  

Unigene Cluster for SOCS1:

Suppressor of cytokine signaling 1
Hs.50640  [show with all ESTs]
Unigene Representative Sequence: AK127621
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000332029(uc002dar.1)
miRNA
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hsa-miR-411* hsa-miR-142-5p hsa-miR-30c hsa-miR-379* hsa-miR-331-3p hsa-miR-548v hsa-miR-30d hsa-miR-221
SwitchGear 3'UTR luciferase reporter plasmidSOCS1 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat SOCS1
Clone
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OriGene ORF clones in mouse, rat for SOCS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SOCS1 (NM_003745)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOCS1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOCS1
Primer
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OriGene qPCR primer pairs and template standards for SOCS1
OriGene qSTAR qPCR primer pairs in human, mouse for SOCS1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOCS1
  QuantiTect SYBR Green Assays in human, mouse, rat SOCS1
  QuantiFast Probe-based Assays in human, mouse, rat SOCS1

Additional mRNA sequence: 

AB000676.1 AB000734.1 AB005043.1 AK127621.1 U88326.1 

4 DOTS entries:

DT.95224537  DT.95152705  DT.317446  DT.95224543 

Selected AceView cDNA sequences (see all 185):

BF111288 BM055229 AW149450 AI313112 BM142265 AI354945 AI955063 AI828951 
AB000734 AB005043 CB054734 AI671628 CA950495 BM142430 NM_003745 AK127621 
BF062204 AI094927 AI434761 BE046965 AI094290 N91127 AI057177 AI683421 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SOCS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTACATATA
SOCS1 Expression
About this image

SOCS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SOCS1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.50640

UniProtKB/Swiss-Prot: SOCS1_HUMAN, O15524
Tissue specificity: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood
leukocytes

    Pathway & Disease-focused RT2 Profiler PCR Arrays including SOCS1 (see all 10): 
          G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
          Th17 Response in human mouse rat
          Leukemia in human mouse rat
          Th1/Th2 Response in human mouse rat
          Type I Interferon Response in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for SOCS1
OriGene qSTAR qPCR primer pairs in human, mouse for SOCS1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOCS1
QuantiTect SYBR Green Assays in human, mouse, rat SOCS1
QuantiFast Probe-based Assays in human, mouse, rat SOCS1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOCS1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SOCS1 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Socs11 , 5 suppressor of cytokine signaling 11, 5 88.47(n)1
91.94(a)1
  16 (5.81 cM)5
127031  NM_001271603.11  NP_001258532.11 
 107838085 
chicken
(Gallus gallus)
Aves SOCS11 suppressor of cytokine signaling 1 63.77(n)
62.32(a)
  416630  NM_001137648.1  NP_001131120.1 
lizard
(Anolis carolinensis)
Reptilia SOCS16
suppressor of cytokine signaling 1
62(a)
1 ↔ 1
AAWZ02038311(2140-2721)
tropical clawed frog
(Xenopus tropicalis)
Amphibia socs11 suppressor of cytokine signaling 1 55.77(n)
58.29(a)
  496789  NM_001011327.1  NP_001011327.1 
zebrafish
(Danio rerio)
Actinopterygii socs1a1 suppressor of cytokine signaling 1a 52.99(n)
46.79(a)
  445073  NM_001003467.1  NP_001003467.1 


ENSEMBL Gene Tree for SOCS1 (if available)
TreeFam Gene Tree for SOCS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SOCS1 gene
SOCS32  SOCS42  SOCS52  SOCS72  SOCS62  CISH2  SOCS22  
1 SIMAP similar gene for SOCS1 using alignment to 2 protein entries:     SOCS1_HUMAN (see all proteins):
SOCS2

Find genes that share paralogs with SOCS1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SOCS1 (see all 120)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs725508121,2
F--11347848(-) TGCTTG/CAAATG 1 -- ds50015Minor allele frequency- C:0.01MN 396
rs47803551,2
C,F,A,H--11347858(+) AGATGC/TTTAGT 1 -- ds500131Minor allele frequency- N:0.00EA NA NS MN WA CSA 2966
rs725508131,2
C,F--11347869(-) TTTGGC/TTGTCC 1 -- ds50017Minor allele frequency- T:0.03MN CSA WA 516
rs725508141,2
C,F--11347894(-) GTCAAA/TGACAA 1 -- ds50017Minor allele frequency- T:0.02MN WA 516
rs725508151,2
F--11347937(-) CTACAG/AAAGGG 1 -- ds50015Minor allele frequency- A:0.02MN 396
rs1448476561,2
--11347969(+) CTCACA/GGGGTT 1 -- ds50010--------
rs1833232171,2
--11348036(+) TGGCAC/TGCACA 1 -- ds50010--------
rs1485783841,2
--11348037(+) GGCACA/GCACAA 1 -- ds50010--------
rs1864942961,2
--11348042(+) GCACAA/GAGTGC 1 -- ds50010--------
rs1429636531,2
C--11348059(+) GCGAGC/TTGCTG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for SOCS1 (11348262 - 11350039 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for SOCS1:    About this table    
Variant IDTypeSubtypePubMed ID
esv23744CNV Loss19812545
nsv525548CNV Loss19592680
nsv827552CNV Gain20364138

Human Gene Mutation Database (HGMD): SOCS1
5 Site Specific Mutation Identification with PCR Assays for SOCS1:
Cosmic IdAA Change
36138p.Q210H
19319p.P198S
19366p.A37fs*27
19356p.E152fs*58
19167p.V117fs*93
SeqTarget long-range PCR primers for resequencing SOCS1
DNA2.0 Custom Variant and Variant Library Synthesis for SOCS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603597    OMIM disorders: --

2 diseases for SOCS1:    
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silent pituitary adenoma    hepatocellular carcinoma


Find genes that share disorders with SOCS1           About GenesLikeMe

Selected Novoseek inferred disease relationships for SOCS1 gene (see all 54)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
microsatellite instability 69.2 2 19470733 (1), 19789368 (1)
colorectal cancer 52.6 24 15793636 (3), 15074307 (3), 14719065 (2), 17339237 (1) (see all 11)
hepatocellular carcinoma 50.3 17 14614012 (2), 18639978 (2), 18606059 (2), 11322203 (1) (see all 13)
tumors 46.4 70 20164024 (4), 17376806 (3), 15373779 (3), 16532038 (3) (see all 42)
colon cancer 44.1 2 17898258 (1), 19551406 (1)
myeloproliferative disorders 40.6 5 18815196 (3), 17030374 (2)
leukemia 36.9 13 9811457 (2), 14616969 (2), 20372794 (1), 18684446 (1) (see all 10)
cancer 33.2 13 16644104 (1), 19342366 (1), 16125365 (1), 16426581 (1) (see all 12)
lymphoma b-cell 30.1 12 19734449 (4), 16287070 (2), 16598306 (1), 17867599 (1) (see all 5)
metastatic melanoma 26.9 2 19047140 (2)

Genetic Association Database (GAD): SOCS1
Human Genome Epidemiology (HuGE) Navigator: SOCS1 (31 documents)

Export disorders for SOCS1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SOCS1 gene, integrated from 10 sources (see all 501):
(articles sorted by number of sources associating them with SOCS1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PubMed id 9266833)1, 2, 3 Minamoto S.... Kishimoto T. (Biochem. Biophys. Res. Commun. 1997)
  2. Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. (PubMed id 17099141)1, 4, 9 Harada M....Tamari M. (Am. J. Respir. Cell Mol. Biol. 2007)
  3. Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. (PubMed id 16410555)1, 2, 9 Ben-Zvi T.... Monsonego-Ornan E. (J. Cell Sci. 2006)
  4. Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus. (PubMed id 20064913)1, 4, 9 Chan H.C....Yen J.H. (Lupus 2010)
  5. Functional SOCS1 polymorphisms are associated with variation in obesity in whites. (PubMed id 19215277)1, 4, 9 Gylvin T....Pociot F. (amp 2009)
  6. A family of cytokine-inducible inhibitors of signaling. (PubMed id 9202125)1, 2, 9 Starr R....Hilton D.J. (Nature 1997)
  7. Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility. (PubMed id 20724312)1, 4 Meulenbelt I....Slagboom P.E. (Ann. Rheum. Dis. 2011)
  8. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
  9. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
  10. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8651 HGNC: 19383 AceView: SOCS1 Ensembl:ENSG00000185338 euGenes: HUgn8651
ECgene: SOCS1 Kegg: 8651 H-InvDB: SOCS1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SOCS1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SOCS1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SOCS1 gene:
Search GeneIP for patents involving SOCS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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