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Aliases for SOAT2 Gene

Aliases for SOAT2 Gene

  • Sterol O-Acyltransferase 2 2 3
  • ACACT2 3 4 6
  • Acyl-Coenzyme A:Cholesterol Acyltransferase 2 3 4
  • Cholesterol Acyltransferase 2 3 4
  • EC 2.3.1.26 4 63
  • ACAT-2 3 4
  • ACAT2 3 4
  • Acyl Coenzyme A:Cholesterol Acyltransferase 2 3
  • Acyl Co-A: Cholesterol Acyltransferase 2 3
  • Acyl-CoA:Cholesterol Acyltransferase 2 3
  • ARGP2 3

External Ids for SOAT2 Gene

Previous GeneCards Identifiers for SOAT2 Gene

  • GC12P053656
  • GC12P053410
  • GC12P053214
  • GC12P051783
  • GC12P053497
  • GC12P050540

Summaries for SOAT2 Gene

Entrez Gene Summary for SOAT2 Gene

  • Summary:This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOAT2 Gene

SOAT2 (Sterol O-Acyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include cholesterol binding and fatty-acyl-CoA binding. An important paralog of this gene is DGAT1.

UniProtKB/Swiss-Prot for SOAT2 Gene

  • Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa

Gene Wiki entry for SOAT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOAT2 Gene

Genomics for SOAT2 Gene

Regulatory Elements for SOAT2 Gene

Genomic Location for SOAT2 Gene

Start:
53,103,490 bp from pter
End:
53,124,539 bp from pter
Size:
21,050 bases
Orientation:
Plus strand

Genomic View for SOAT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOAT2 Gene

Proteins for SOAT2 Gene

  • Protein details for SOAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75908-SOAT2_HUMAN
    Recommended name:
    Sterol O-acyltransferase 2
    Protein Accession:
    O75908
    Secondary Accessions:
    • F5H7W4
    • I6L9H9
    • Q4VB99
    • Q4VBA1
    • Q96TD4
    • Q9UNR2

    Protein attributes for SOAT2 Gene

    Size:
    522 amino acids
    Molecular mass:
    59896 Da
    Quaternary structure:
    • May form homo- or heterodimers.

    Alternative splice isoforms for SOAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOAT2 Gene

Proteomics data for SOAT2 Gene at MOPED

Selected DME Specific Peptides for SOAT2 Gene

Post-translational modifications for SOAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for SOAT2 Gene

Protein Domains for SOAT2 Gene

Suggested Antigen Peptide Sequences for SOAT2 Gene

Graphical View of Domain Structure for InterPro Entry

O75908

UniProtKB/Swiss-Prot:

SOAT2_HUMAN :
  • O75908
Family:
  • Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
genes like me logo Genes that share domains with SOAT2: view

No data available for Gene Families for SOAT2 Gene

Function for SOAT2 Gene

Molecular function for SOAT2 Gene

GENATLAS Biochemistry: sterol O-acyltransferase 2,a crucial element of intracellular lipid homeostasis
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + cholesterol = CoA + cholesterol ester
UniProtKB/Swiss-Prot Function: Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa

Enzyme Numbers (IUBMB) for SOAT2 Gene

Gene Ontology (GO) - Molecular Function for SOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IDA 16647063
GO:0004772 sterol O-acyltransferase activity --
GO:0008374 O-acyltransferase activity --
GO:0015485 cholesterol binding IDA 16647063
GO:0016746 transferase activity, transferring acyl groups TAS 9756920
genes like me logo Genes that share ontologies with SOAT2: view
genes like me logo Genes that share phenotypes with SOAT2: view

Animal Models for SOAT2 Gene

MGI Knock Outs for SOAT2:

Animal Model Products

CRISPR Products

miRNA for SOAT2 Gene

miRTarBase miRNAs that target SOAT2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOAT2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for SOAT2 Gene

Localization for SOAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOAT2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOAT2 Gene COMPARTMENTS Subcellular localization image for SOAT2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for SOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 15451793
GO:0005789 endoplasmic reticulum membrane IDA 12808042
GO:0005903 brush border IDA 14615411
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SOAT2: view

Pathways for SOAT2 Gene

genes like me logo Genes that share pathways with SOAT2: view

Interacting Proteins for SOAT2 Gene

Gene Ontology (GO) - Biological Process for SOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0008203 cholesterol metabolic process IDA 16647063
GO:0010742 macrophage derived foam cell differentiation TAS 14615411
GO:0030299 intestinal cholesterol absorption IC 14615411
GO:0033344 cholesterol efflux IMP 15308631
genes like me logo Genes that share ontologies with SOAT2: view

Compounds for SOAT2 Gene

(66) HMDB Compounds for SOAT2 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(1) Drugbank Compounds for SOAT2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Hesperetin
  • Cyanidanon 4'-Methyl Ether 1626
520-33-2 target inhibitor

(12) Novoseek inferred chemical compound relationships for SOAT2 Gene

Compound -log(P) Hits PubMed IDs
pyripyropene a 93.5 5
avasimibe 80.2 1
cholesterol 69.7 39
cholesterol ester 67.2 3
sterol 67.1 4
genes like me logo Genes that share compounds with SOAT2: view

Transcripts for SOAT2 Gene

mRNA/cDNA for SOAT2 Gene

(8) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOAT2 Gene

Sterol O-acyltransferase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOAT2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SOAT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOAT2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -

Relevant External Links for SOAT2 Gene

GeneLoc Exon Structure for
SOAT2
ECgene alternative splicing isoforms for
SOAT2

Expression for SOAT2 Gene

mRNA expression in normal human tissues for SOAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOAT2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (8.0), Spleen (5.1), and Liver (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SOAT2 Gene

SOURCE GeneReport for Unigene cluster for SOAT2 Gene Hs.656544

mRNA Expression by UniProt/SwissProt for SOAT2 Gene

O75908-SOAT2_HUMAN
Tissue specificity: Expression seems confined in hepatocytes and enterocytes.
genes like me logo Genes that share expressions with SOAT2: view

In Situ Assay Products

Orthologs for SOAT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOAT2 35
  • 99.3 (n)
  • 99.23 (a)
SOAT2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SOAT2 35
  • 87.05 (n)
  • 86.15 (a)
SOAT2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SOAT2 35
  • 85.64 (n)
  • 83.85 (a)
SOAT2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Soat2 35
  • 83.82 (n)
  • 82.85 (a)
Soat2 16
Soat2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOAT2 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Soat2 35
  • 84.07 (n)
  • 82.85 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.10984 35
tropical clawed frog
(Silurana tropicalis)
Amphibia soat2 35
  • 62.15 (n)
  • 57.96 (a)
Str.20260 35
zebrafish
(Danio rerio)
Actinopterygii soat2 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8112 36
  • 29 (a)
OneToMany
CG8112 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea mboa-1 36
  • 26 (a)
OneToMany
B0395.2 37
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARE1 36
  • 14 (a)
ManyToMany
ARE2 36
  • 13 (a)
ManyToMany
Species with no ortholog for SOAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOAT2 Gene

ENSEMBL:
Gene Tree for SOAT2 (if available)
TreeFam:
Gene Tree for SOAT2 (if available)

Paralogs for SOAT2 Gene

Paralogs for SOAT2 Gene

Selected SIMAP similar genes for SOAT2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SOAT2: view

Variants for SOAT2 Gene

Sequence variations from dbSNP and Humsavar for SOAT2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs711315 -- 53,118,986(+) GAGAG(G/T)GGACA intron-variant
rs822681 -- 53,118,315(+) CCCTT(A/G)CCCTT intron-variant
rs822682 -- 53,118,660(+) CTGTC(C/T)TGATA intron-variant
rs822683 -- 53,119,364(+) GTCTC(C/T)CCTCA intron-variant
rs822684 -- 53,120,084(+) TAATC(A/C)CAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SOAT2 Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680
nsv899099 CNV Loss 21882294
nsv470294 CNV Loss 18288195
nsv712 CNV Insertion 18451855
nsv832417 CNV Gain 17160897
nsv470295 CNV Gain 18288195
nsv713 CNV Insertion 18451855
nsv469404 CNV Loss 19166990

Relevant External Links for SOAT2 Gene

HapMap Linkage Disequilibrium report
SOAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOAT2 Gene

Disorders for SOAT2 Gene

(6) Novoseek inferred disease relationships for SOAT2 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 51.6 4
hypercholesterolemia 40.6 1
hyperlipidemia 33.9 1
coronary heart disease 15 2
dyslipidemia 13.5 4

Relevant External Links for SOAT2

Genetic Association Database (GAD)
SOAT2
Human Genome Epidemiology (HuGE) Navigator
SOAT2
genes like me logo Genes that share disorders with SOAT2: view

No data available for UniProtKB/Swiss-Prot for SOAT2 Gene

Publications for SOAT2 Gene

  1. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. (PMID: 9756920) Oelkers P. … Sturley S.L. (J. Biol. Chem. 1998) 2 3 4 23
  2. Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine. (PMID: 10846185) Chang C.C.Y. … Chang T.-Y. (J. Biol. Chem. 2000) 3 4 23
  3. Organization of human ACAT-2 gene and its cell-type-specific promoter activity. (PMID: 11401500) Song B.L. … Li B.L. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  4. Structure of the human acyl-CoA:cholesterol acyltransferase-2 (ACAT- 2) gene and its relation to dyslipidemia. (PMID: 11325614) Katsuren K. … Ohta T. (Biochim. Biophys. Acta 2001) 3 4 23
  5. Two human ACAT2 mRNA variants produced by alternative splicing and coding for novel isoenzymes. (PMID: 16331323) Yao X.M. … Li B.L. (Acta Biochim. Biophys. Sin. (Shanghai) 2005) 3 4 23

Products for SOAT2 Gene

Sources for SOAT2 Gene

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