Aliases for SOAT2 Gene
External Ids for SOAT2 Gene
Previous GeneCards Identifiers for SOAT2 Gene
Summary:This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOAT2 Gene
SOAT2 (Sterol O-Acyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include cholesterol binding and fatty-acyl-CoA binding. An important paralog of this gene is DGAT1.
UniProtKB/Swiss-Prot for SOAT2 Gene
Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa