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Aliases for SOAT1 Gene

Aliases for SOAT1 Gene

  • Sterol O-Acyltransferase 1 2 3
  • ACAT 3 4 6
  • STAT 3 4 6
  • Sterol O-Acyltransferase (Acyl-Coenzyme A: Cholesterol Acyltransferase) 1 2 3
  • Acyl-Coenzyme A:Cholesterol Acyltransferase 1 3 4
  • EC 2.3.1.26 4 63
  • ACAT-1 3 4
  • ACACT 3 4
  • ACAT1 3 4
  • SOAT 3 4
  • Acyl-Coenzyme A: Cholesterol Acyltransferase 2
  • Cholesterol Acyltransferase 1 4
  • ACACT1 4

External Ids for SOAT1 Gene

Previous HGNC Symbols for SOAT1 Gene

  • SOAT
  • STAT

Previous GeneCards Identifiers for SOAT1 Gene

  • GC01P176787
  • GC01P174691
  • GC01P175783
  • GC01P176502
  • GC01P176453
  • GC01P175994
  • GC01P177529
  • GC01P150491

Summaries for SOAT1 Gene

Entrez Gene Summary for SOAT1 Gene

  • The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for SOAT1 Gene

SOAT1 (Sterol O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with SOAT1 include gallbladder disease and homozygous familial hypercholesterolemia. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include cholesterol binding and cholesterol O-acyltransferase activity. An important paralog of this gene is SOAT2.

UniProtKB/Swiss-Prot for SOAT1 Gene

  • Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase

Tocris Summary for SOAT1 Gene

  • Acyl-CoA: cholesterol acyltransferase (ACAT) is an ER-bound intracellular enzyme that forms cholesterol esters from cholesterol. ACAT decreases the solubility of cholesterol and prevents its incorporation into lipid membranes, and it is a vital enzyme in the biosynthesis of bile acids. However, ACAT also plays an important role in foam cell formation and atherosclerosis due to cholesterol accumulation in macrophages.

Gene Wiki entry for SOAT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOAT1 Gene

Genomics for SOAT1 Gene

Regulatory Elements for SOAT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SOAT1 Gene

Start:
179,293,714 bp from pter
End:
179,358,680 bp from pter
Size:
64,967 bases
Orientation:
Plus strand

Genomic View for SOAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOAT1 Gene

Proteins for SOAT1 Gene

  • Protein details for SOAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35610-SOAT1_HUMAN
    Recommended name:
    Sterol O-acyltransferase 1
    Protein Accession:
    P35610
    Secondary Accessions:
    • A6NC40
    • A8K3P4
    • A9Z1V7
    • B4DU95
    • Q5T0X4
    • Q8N1E4

    Protein attributes for SOAT1 Gene

    Size:
    550 amino acids
    Molecular mass:
    64735 Da
    Quaternary structure:
    • May form homo- or heterodimers. Interacts with UBIAD1.

    Alternative splice isoforms for SOAT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOAT1 Gene

Proteomics data for SOAT1 Gene at MOPED

Post-translational modifications for SOAT1 Gene

  • Ubiquitination at Lys45, Lys62, Lys120, and Lys531
  • Modification sites at PhosphoSitePlus

Other Protein References for SOAT1 Gene

Antibody Products

Domains for SOAT1 Gene

Protein Domains for SOAT1 Gene

Graphical View of Domain Structure for InterPro Entry

P35610

UniProtKB/Swiss-Prot:

SOAT1_HUMAN :
  • P35610
Family:
  • Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
genes like me logo Genes that share domains with SOAT1: view

No data available for Gene Families for SOAT1 Gene

Function for SOAT1 Gene

Molecular function for SOAT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + cholesterol = CoA + cholesterol ester
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase
UniProtKB/Swiss-Prot Induction:
Highly activated by the presence of cholesterol

Enzyme Numbers (IUBMB) for SOAT1 Gene

Gene Ontology (GO) - Molecular Function for SOAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IDA 16647063
GO:0004772 sterol O-acyltransferase activity IMP 8407899
GO:0005515 protein binding IPI 23169578
GO:0015485 cholesterol binding IDA 16647063
GO:0034736 cholesterol O-acyltransferase activity IMP 8407899
genes like me logo Genes that share ontologies with SOAT1: view
genes like me logo Genes that share phenotypes with SOAT1: view

Animal Models for SOAT1 Gene

MGI Knock Outs for SOAT1:

Animal Model Products

No data available for Transcription Factor Targeting and HOMER Transcription for SOAT1 Gene

Localization for SOAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SOAT1 Gene COMPARTMENTS Subcellular localization image for SOAT1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for SOAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IDA 17412327
GO:0016020 membrane IDA 9756919
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SOAT1: view

Pathways for SOAT1 Gene

genes like me logo Genes that share pathways with SOAT1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat

Gene Ontology (GO) - Biological Process for SOAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008203 cholesterol metabolic process IMP 8407899
GO:0010742 macrophage derived foam cell differentiation NAS 18971559
GO:0010878 cholesterol storage IMP 8407899
GO:0033344 cholesterol efflux IMP 15308631
GO:0034379 very-low-density lipoprotein particle assembly IMP 15308631
genes like me logo Genes that share ontologies with SOAT1: view

Compounds for SOAT1 Gene

(5) Tocris Compounds for SOAT1 Gene

Compound Action Cas Number
(R)-(+)-Etomoxir sodium salt Carnitine palmitoyltransferase I (CPT1) inhibitor [828934-41-4]
A 922500 Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor [959122-11-3]
Fumonisin B1 Inhibitor of sphingosine N-acyltransferase [116355-83-0]
N1,N11-Diethylnorspermine tetrahydrochloride Spermine and spermidine acetyltransferase potentiator [156886-85-0]
Wnt-C59 Highly potent Porcn inhibitor [1243243-89-1]

(67) HMDB Compounds for SOAT1 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(2) Drugbank Compounds for SOAT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ezetimibe
163222-33-1 target inhibitor
Hesperetin
  • Cyanidanon 4'-Methyl Ether 1626
520-33-2 target inhibitor

(71) Novoseek inferred chemical compound relationships for SOAT1 Gene

Compound -log(P) Hits PubMed IDs
avasimibe 89.3 17
pyripyropene a 86.4 4
pactimibe 80.3 4
tyrosine 78.6 128
gp 130 77.6 16
genes like me logo Genes that share compounds with SOAT1: view

Transcripts for SOAT1 Gene

Unigene Clusters for SOAT1 Gene

Sterol O-acyltransferase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOAT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOAT1 Gene

No ASD Table

Relevant External Links for SOAT1 Gene

GeneLoc Exon Structure for
SOAT1
ECgene alternative splicing isoforms for
SOAT1

Expression for SOAT1 Gene

mRNA expression in normal human tissues for SOAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOAT1 Gene

This gene is overexpressed in Adrenal Gland (11.4).

Protein differential expression in normal tissues for SOAT1 Gene

This gene is overexpressed in Monocytes (18.8), Breast (11.5), Adrenal (8.6), Islet of Langerhans (8.1), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SOAT1 Gene

SOURCE GeneReport for Unigene cluster for SOAT1 Gene Hs.445588

genes like me logo Genes that share expressions with SOAT1: view

Expression partners for SOAT1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SOAT1 Gene

Orthologs for SOAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOAT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SOAT1 35
  • 87.92 (n)
  • 85.25 (a)
SOAT1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC490325 35
  • 90.77 (n)
  • 89.98 (a)
SOAT1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Soat1 35
  • 83.89 (n)
  • 87.04 (a)
Soat1 16
Soat1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SOAT1 35
  • 99.94 (n)
  • 100 (a)
SOAT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Soat1 35
  • 83.85 (n)
  • 86.24 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SOAT1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOAT1 35
  • 69.61 (n)
  • 70.72 (a)
SOAT1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOAT1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia soat1 35
  • 66.11 (n)
  • 68.69 (a)
Str.11436 35
zebrafish
(Danio rerio)
Actinopterygii soat1 35
  • 62.54 (n)
  • 61.92 (a)
soat1 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8112 37
  • 37 (a)
CG8112 35
  • 46.09 (n)
  • 39.3 (a)
CG8112 36
  • 34 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012216 35
  • 48.11 (n)
  • 38.03 (a)
worm
(Caenorhabditis elegans)
Secernentea B0395.2 37
  • 35 (a)
mboa-1 35
  • 47.38 (n)
  • 36.22 (a)
mboa-1 36
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARE1 36
  • 15 (a)
ManyToMany
ARE2 36
  • 15 (a)
ManyToMany
Species with no ortholog for SOAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOAT1 Gene

ENSEMBL:
Gene Tree for SOAT1 (if available)
TreeFam:
Gene Tree for SOAT1 (if available)

Paralogs for SOAT1 Gene

Paralogs for SOAT1 Gene

Selected SIMAP similar genes for SOAT1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SOAT1: view

Variants for SOAT1 Gene

Sequence variations from dbSNP and Humsavar for SOAT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1034269 -- 179,335,757(+) tggtg(C/T)cactt intron-variant
rs1044925 -- 179,354,603(+) CTGTA(A/C)CATAA utr-variant-3-prime, nc-transcript-variant
rs1475798 -- 179,310,888(-) AAGCA(A/G)TGACT intron-variant
rs1475799 -- 179,310,847(-) AATAA(A/G)TGTTT intron-variant
rs1543730 -- 179,310,287(-) ACACC(A/C)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SOAT1 Gene

Variant ID Type Subtype PubMed ID
esv2666168 CNV Deletion 23128226
esv990767 CNV Deletion 20482838
nsv523708 CNV Loss 19592680
nsv518403 CNV Gain 19592680

Relevant External Links for SOAT1 Gene

HapMap Linkage Disequilibrium report
SOAT1
Human Gene Mutation Database (HGMD)
SOAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOAT1 Gene

Disorders for SOAT1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SOAT1 Gene in MalaCards »

(3) Diseases for SOAT1 Gene including...

(1) University of Copenhagen DISEASES for SOAT1 Gene

(56) Novoseek inferred disease relationships for SOAT1 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 56.1 37
atherosclerotic plaque 43.2 8
leukemogenesis 43 4
leukemia 39.2 15
hypercholesterolemia 36.4 8

Relevant External Links for SOAT1

Genetic Association Database (GAD)
SOAT1
Human Genome Epidemiology (HuGE) Navigator
SOAT1
genes like me logo Genes that share disorders with SOAT1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for SOAT1 Gene

Publications for SOAT1 Gene

  1. Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. (PMID: 8407899) Chang C.C.Y. … Chang T.-Y. (J. Biol. Chem. 1993) 2 3 4 23
  2. Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains. (PMID: 10438503) Lin S. … Chang T.-Y. (J. Biol. Chem. 1999) 3 4 23
  3. The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain. (PMID: 16154994) Guo Z.Y. … Chang T.Y. (J. Biol. Chem. 2005) 3 4 23
  4. Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer's disease in Chinese. (PMID: 16043284) Zhao F.G. … Chan P. (Neurosci. Lett. 2005) 3 23 48
  5. Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers. (PMID: 17622762) Lamsa R. … Soininen H. (Dement Geriatr Cogn Disord 2007) 3 23 48

Products for SOAT1 Gene

Sources for SOAT1 Gene

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