Aliases for SOAT1 Gene
External Ids for SOAT1 Gene
Previous HGNC Symbols for SOAT1 Gene
Previous GeneCards Identifiers for SOAT1 Gene
The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for SOAT1 Gene
SOAT1 (Sterol O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with SOAT1 include gallbladder disease and homozygous familial hypercholesterolemia. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include cholesterol binding and cholesterol O-acyltransferase activity. An important paralog of this gene is SOAT2.
UniProtKB/Swiss-Prot for SOAT1 Gene
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase
Acyl-CoA: cholesterol acyltransferase (ACAT) is an ER-bound intracellular enzyme that forms cholesterol esters from cholesterol. ACAT decreases the solubility of cholesterol and prevents its incorporation into lipid membranes, and it is a vital enzyme in the biosynthesis of bile acids. However, ACAT also plays an important role in foam cell formation and atherosclerosis due to cholesterol accumulation in macrophages.