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SOAT1 Gene

protein-coding   GIFtS: 63
GCID: GC01P179262

Sterol O-Acyltransferase 1

(Previous name: sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase)...)
(Previous symbols: SOAT, STAT)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sterol O-Acyltransferase 11 2     ACAT-12 3
STAT1 2 3 5     ACAT12 3
SOAT1 2 3     EC 2.3.1.263 8
ACAT2 3 5     Acyl-Coenzyme A: Cholesterol Acyltransferase1
Sterol O-Acyltransferase (Acyl-Coenzyme A: Cholesterol Acyltransferase) 11 2     ACACT13
Acyl-Coenzyme A:Cholesterol Acyltransferase 12 3     Cholesterol Acyltransferase 13
ACACT2 3     

External Ids:    HGNC: 111771   Entrez Gene: 66462   Ensembl: ENSG000000572527   OMIM: 1026425   UniProtKB: P356103   

Export aliases for SOAT1 gene to outside databases

Previous GC identifers: GC01P176787 GC01P174691 GC01P175783 GC01P176502 GC01P176453 GC01P175994 GC01P177529 GC01P150491


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SOAT1 Gene:
The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic
reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the
formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and
cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene.
(provided by RefSeq, Nov 2011)

GeneCards Summary for SOAT1 Gene:
SOAT1 (sterol O-acyltransferase 1) is a protein-coding gene. Diseases associated with SOAT1 include laron syndrome, and gallbladder disease. GO annotations related to this gene include cholesterol binding and cholesterol O-acyltransferase activity. An important paralog of this gene is DGAT1.

UniProtKB/Swiss-Prot: SOAT1_HUMAN, P35610
Function: Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and
dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase

summary for SOAT1 Gene:
Acyl-CoA: cholesterol acyltransferase (ACAT) is an ER-bound intracellular enzyme that forms cholesterol
esters from cholesterol. ACAT decreases the solubility of cholesterol and prevents its incorporation into
lipid membranes, and it is a vital enzyme in the biosynthesis of bile acids. However, ACAT also plays an
important role in foam cell formation and atherosclerosis due to cholesterol accumulation in macrophages.

Gene Wiki entry for SOAT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SOAT1 gene promoter:
         TBP   C/EBPbeta   p53   TFIID   STAT3   IRF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SOAT1 promoter sequence
   Search Chromatin IP Primers for SOAT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SOAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25

SOAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOAT1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P179262:  view genomic region     (about GC identifiers)

Start:
179,262,925 bp from pter      End:
179,327,815 bp from pter
Size:
64,891 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SOAT1_HUMAN, P35610 (See protein sequence)
Recommended Name: Sterol O-acyltransferase 1  
Size: 550 amino acids; 64735 Da
Subunit: May form homo- or heterodimers. Interacts with UBIAD1
Secondary accessions: A6NC40 A8K3P4 A9Z1V7 B4DU95 Q5T0X4 Q8N1E4
Alternative splicing: 3 isoforms:  P35610-1   P35610-2   P35610-3   

Explore the universe of human proteins at neXtProt for SOAT1: NX_P35610

Explore proteomics data for SOAT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys45, Lys62, Lys120, Lys531
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SOAT1 (P35610) (see all 14)
     DWWNSTS  IVNDSRK  RRSLLDEL  YAFGKFPTV 


    See SOAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001239440.1  NP_001239441.1  NP_003092.4  

    ENSEMBL proteins: 
     ENSP00000356591   ENSP00000411309   ENSP00000445315   ENSP00000441356   ENSP00000442503  

    SOAT1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SOAT1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SOAT1
    GenScript Custom Purified and Recombinant Proteins Services for SOAT1
    Novus Biologicals SOAT1 Protein
    Novus Biologicals SOAT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SOAT1

    SOAT1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SOAT1
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    OriGene Custom Antibody Services for SOAT1
    Novus Biologicals SOAT1 Antibodies
    Abcam antibodies for SOAT1 (Q5T0X4, P35610)
    Cloud-Clone Corp. Antibodies for SOAT1
    Search ThermoFisher Antibodies for SOAT1
    LSBio Antibodies in human, mouse, rat for SOAT1

    SOAT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SOAT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SOAT1
    Cloud-Clone Corp. CLIAs for SOAT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR014371 Oat_ACAT_DAG_ARE
     IPR004299 MBOAT_fam

    Graphical View of Domain Structure for InterPro Entry P35610

    ProtoNet protein and cluster: P35610

    1 Blocks protein domain: IPB004299 Membrane bound O-acyl transferase

    UniProtKB/Swiss-Prot: SOAT1_HUMAN, P35610
    Similarity: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily


    SOAT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOAT1_HUMAN, P35610
    Function: Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and
    dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase
    Catalytic activity: Acyl-CoA + cholesterol = CoA + cholesterol ester
    Induction: Highly activated by the presence of cholesterol

         Enzyme Number (IUBMB): EC 2.3.1.261 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000062fatty-acyl-CoA binding IDA16647063
    GO:0004772sterol O-acyltransferase activity IMP8407899
    GO:0005515protein binding IPI--
    GO:0015485cholesterol binding IDA16647063
    GO:0034736cholesterol O-acyltransferase activity IMP8407899
         
    SOAT1 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Soat1):
     cardiovascular system  cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  nervous system  tumorigenesis 
     vision/eye 

    SOAT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SOAT1: Soat1tm1Far Soat1tm1Ishi

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SOAT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SOAT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SOAT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SOAT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SOAT1:
    hsa-mir-186-5p (MIRT045139), hsa-mir-500a-3p (MIRT041152), hsa-mir-98-5p (MIRT027734), hsa-mir-192-5p (MIRT026807), hsa-mir-1303 (MIRT035871), hsa-mir-215-5p (MIRT024321), hsa-mir-193b-3p (MIRT016592)

    Block miRNA regulation of human, mouse, rat SOAT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOAT1 (see all 13):
    hsa-miR-2052 hsa-miR-548p hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-885-5p hsa-miR-141* hsa-miR-9 hsa-miR-19b-1*
    SwitchGear 3'UTR luciferase reporter plasmidSOAT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SOAT1
    Predesigned siRNA for gene silencing in human, mouse, rat SOAT1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SOAT1

    Clone
    Products:
         
    OriGene clones in human, mouse for SOAT1 (see all 6)
    OriGene ORF clones in mouse, rat for SOAT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOAT1 (NM_003101)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOAT1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SOAT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SOAT1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOAT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SOAT1_HUMAN, P35610: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    extracellular2
    peroxisome2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IDA17412327
    GO:0016020membrane IDA9756919
    GO:0016021integral component of membrane IEA--

    SOAT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SOAT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Statin Pathway
    Statin Pathway0.73
    Statin Pathway, Pharmacodynamics0.73
    2superpathway of cholesterol biosynthesis
    Steroid biosynthesis0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SOAT1
        Statin Pathway

    1 PharmGKB Pathway for SOAT1
        Statin Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for SOAT1):
        Steroid biosynthesis


    SOAT1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SOAT1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SOAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SOAT1 (P356101, 2 ENSP000003565914) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CANXP278242MINT-8374864
    UBIAD1Q9Y5Z91EBI-6621997,EBI-2819725
    CELENSP000003611514STRING: ENSP00000361151
    DHCR24ENSP000003603164STRING: ENSP00000360316
    DHCR7ENSP000003477174STRING: ENSP00000347717
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008203cholesterol metabolic process IMP8407899
    GO:0010742macrophage derived foam cell differentiation NAS18971559
    GO:0010878cholesterol storage IMP8407899
    GO:0033344cholesterol efflux IMP15308631
    GO:0034379very-low-density lipoprotein particle assembly IMP15308631

    SOAT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SOAT1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    YM 750Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor[138046-43-2]
    VULM 1457Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor[228544-65-8]
    N1,N11-Diethylnorspermine tetrahydrochloride Spermine and spermidine acetyltransferase potentiator[121749-39-1]
    (R)-(+)-Etomoxir sodium saltCarnitine palmitoyltransferase I (CPT1) inhibitor[828934-41-4]
    A 922500Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor[959122-11-3]

    Selected HMDB Compounds for SOAT1 (see all 67)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    2 DrugBank Compounds for SOAT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ezetimibe-- 163222-33-1targetinhibitor20227438 19669185 18442485
    HesperetinCyanidanon 4'-Methyl Ether 1626 (see all 3)520-33-2targetinhibitor15114505 11352979

    Selected Novoseek inferred chemical compound relationships for SOAT1 gene (see all 71)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    avasimibe 89.3 18 10634802 (3), 11853686 (2), 11427213 (2), 14644397 (2) (see all 12)
    pyripyropene a 86.4 6 8982343 (1), 13679053 (1), 18997389 (1), 15451793 (1)
    pactimibe 80.3 4 16554527 (1), 16824833 (1), 16730694 (1), 19293413 (1)
    tyrosine 78.6 197 10380880 (4), 8756628 (3), 10851052 (3), 14578356 (3) (see all 99)
    gp 130 77.6 17 10623831 (2), 7797460 (2), 18246092 (2), 9618263 (1) (see all 13)
    cholesterol ester 75.8 37 19644050 (2), 16172428 (2), 12520177 (1), 15063831 (1) (see all 18)
    cholesterol 70.2 366 8960784 (8), 8006519 (6), 12975367 (6), 8652654 (5) (see all 99)
    25-hydroxycholesterol 63.2 10 1630282 (2), 8652654 (1), 9559223 (1), 15317807 (1) (see all 7)
    sterol 60.3 33 12975367 (2), 15992359 (2), 9242919 (1), 14729857 (1) (see all 18)
    ifn-alpha 58.2 2 10777558 (1), 10470819 (1)



    SOAT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SOAT1 gene (3 alternative transcripts): 
    NM_001252511.1  NM_001252512.1  NM_003101.5  

    Unigene Cluster for SOAT1:

    Sterol O-acyltransferase 1
    Hs.445588  [show with all ESTs]
    Unigene Representative Sequence: NM_003101
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367619(uc001gml.3 uc010pni.2 uc001gmm.3 uc010pnj.2 uc010pnk.2)
    ENST00000426956 ENST00000540564 ENST00000539888 ENST00000535686
    miRNA
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    Block miRNA regulation of human, mouse, rat SOAT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SOAT1 (see all 13):
    hsa-miR-2052 hsa-miR-548p hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-885-5p hsa-miR-141* hsa-miR-9 hsa-miR-19b-1*
    SwitchGear 3'UTR luciferase reporter plasmidSOAT1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SOAT1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SOAT1 (NM_003101)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOAT1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SOAT1
    OriGene qSTAR qPCR primer pairs in human, mouse for SOAT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOAT1
      QuantiTect SYBR Green Assays in human, mouse, rat SOAT1
      QuantiFast Probe-based Assays in human, mouse, rat SOAT1

    Additional mRNA sequence: 

    AK026611.1 AK290659.1 AK294047.1 AK300551.1 AK310920.1 AK316401.1 AL833625.1 BC028940.1 
    L21934.2 NR_045530.1 

    16 DOTS entries:

    DT.100776222  DT.97821734  DT.100776223  DT.109635  DT.100025081  DT.411717  DT.121446664  DT.121446536 
    DT.121446656  DT.121446475  DT.40317182  DT.95307737  DT.95211062  DT.95225995  DT.95267467  DT.99979412 

    Selected AceView cDNA sequences (see all 142):

    AU154020 BX952510 BG697784 BQ019926 BU632602 BG674469 AA658096 BC028940 
    CA488622 BG697850 CA309399 CB148519 AL710904 BM992574 BP375996 BU625553 
    BQ887458 NM_003101 R07296 BQ001792 CK822097 AW002840 CR597057 BG743201 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SOAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGATATTC
    SOAT1 Expression
    About this image


    SOAT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SOAT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SOAT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445588
        Pathway & Disease-focused RT2 Profiler PCR Array including SOAT1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SOAT1
    OriGene qSTAR qPCR primer pairs in human, mouse for SOAT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SOAT1
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    QuantiFast Probe-based Assays in human, mouse, rat SOAT1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOAT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SOAT1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Soat11 , 5 sterol O-acyltransferase 11, 5 83.89(n)1
    87.04(a)1
      1 (67.71 cM)5
    206521  NM_009230.31  NP_033256.21 
     1564281085 
    chicken
    (Gallus gallus)
    Aves SOAT11 sterol O-acyltransferase 1 69.61(n)
    70.72(a)
      424424  XM_004943237.1  XP_004943294.1 
    lizard
    (Anolis carolinensis)
    Reptilia SOAT16
    sterol O-acyltransferase 1
    64(a)
    1 ↔ 1
    GL343300.1(903481-950041)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.114362 Transcribed sequence with moderate similarity to protein more 75.44(n)    AL876427.2 
    zebrafish
    (Danio rerio)
    Actinopterygii soat11 sterol O-acyltransferase 1 62.54(n)
    61.92(a)
      564424  NM_001123272.1  NP_001116744.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81121 , 3 sterol O-acyltransferase3
    CG81121
    37(a)3
    46.09(n)1
    39.3(a)1
      85A83
    410331  NM_169235.41  NP_731269.21 
    worm
    (Caenorhabditis elegans)
    Secernentea B0395.23
    mboa-11
    Sterol O-acyltransferase3
    mboa-11
    35(a)3
    47.38(n)1
    36.22(a)1
      X(16061623-16065478)3
    1816811  NM_078222.41  NP_510623.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARE16
    ARE26
    Acyl-CoA:sterol acyltransferase, isozyme of Are2p;...
    Acyl-CoA:sterol acyltransferase, isozyme of Are1p;...
    15(a)
    15(a)
    many ↔ many
    many ↔ many
    III(211929-213761) YCR048W
    XIV(665339-667267) YNR019W


    ENSEMBL Gene Tree for SOAT1 (if available)
    TreeFam Gene Tree for SOAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SOAT1 gene
    DGAT12  SOAT22  
    1 SIMAP similar gene for SOAT1 using alignment to 3 protein entries:     SOAT1_HUMAN (see all proteins):
    SOAT2

    SOAT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SOAT1 (see all 1656)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs596959021,2
    C--150496102(+) TTTTT-/TT/TTT
            
    GAGAC
    7 -- int1 cds11NA 2
    rs562251791,2
    C--179265046(+) TCTCCT/-GCCTC 4 -- int11Minor allele frequency- -:0.00NA 2
    rs718721311,2
    C--179265047(+) CTCCG-/TCCTCA 4 -- int10--------
    rs596701551,2
    C--179267137(+) AAAAAA/-GATTG 4 -- int11Minor allele frequency- -:0.00CSA 2
    rs113714921,2
    C--179269056(+) TTTTTT/-GTATT 4 -- int11Minor allele frequency- -:0.00NA 2
    rs57790191,2
    C--179271161(+) AATCC-/TTTTTT 4 -- int1 trp30--------
    rs561831141,2
    C--179271176(+) TTTTT-/T/TT  
            
    ACATA
    4 -- int12NA 4
    rs725011551,2
    C--179274243(+) CTCTC-/TTCCTCT 4 -- int10--------
    rs602812431,2
    C--179274550(+) TTTTT-/TTGTGGC 4 -- int10--------
    rs711119051,2
    C--179275966(-) TTTTTT/-TGAGA 4 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for SOAT1 (179262925 - 179327815 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SOAT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv990767CNV Deletion20482838
    esv2666168CNV Deletion23128226
    nsv523708CNV Loss19592680
    nsv518403CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 102642    OMIM disorders: --

    Selected diseases for SOAT1 (see all 55):    
    About MalaCards
    laron syndrome    gallbladder disease    gallbladder adenocarcinoma    atherosclerosis
    hypercholesterolemia    pulmonary alveolar proteinosis    familial hypercholesterolemia    familial breast cancer
    hepatitis b virus infection    protein s deficiency    cutaneous t cell lymphoma    meningioma
    lymphoblastic leukemia    squamous cell carcinoma of the head and neck    coronary heart disease    neurofibromatosis
    hepatitis c    gastric adenocarcinoma    inflammatory bowel disease    coronary artery disease

    1 disease from the University of Copenhagen DISEASES database for SOAT1:
    Atherosclerosis

    SOAT1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SOAT1 gene (see all 56)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 56.1 42 15699266 (2), 16820149 (2), 16180116 (2), 16554527 (1) (see all 34)
    atherosclerotic plaque 43.2 8 16824833 (2), 16554527 (1), 14615411 (1), 15961705 (1) (see all 7)
    leukemogenesis 43 8 12480704 (2), 19667270 (2)
    leukemia 39.2 20 10851048 (3), 14722044 (3), 12480704 (2), 19370975 (2) (see all 9)
    hypercholesterolemia 36.4 10 16462051 (1), 11290819 (1), 16141549 (1), 9247875 (1) (see all 8)
    chronic leukemia 31.9 2 10851048 (1), 11882364 (1)
    laron syndrome 27.8 2 10102076 (1)
    parainfluenza 26.3 2 17250865 (1), 15956600 (1)
    hyperlipidemia 26.2 7 15158756 (2), 16081263 (1), 17872457 (1), 15164335 (1) (see all 5)
    tumors 18.2 36 9662066 (2), 12438264 (2), 17497288 (2), 16264989 (2) (see all 29)

    Genetic Association Database (GAD): SOAT1
    Human Genome Epidemiology (HuGE) Navigator: SOAT1 (10 documents)

    Export disorders for SOAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SOAT1 gene, integrated from 10 sources (see all 631):
    (articles sorted by number of sources associating them with SOAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. (PubMed id 8407899)1, 2, 3, 9 Chang C.C.Y.... Chang T.-Y. (J. Biol. Chem. 1993)
    2. Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains. (PubMed id 10438503)1, 2, 9 Lin S.... Chang T.-Y. (J. Biol. Chem. 1999)
    3. Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers. (PubMed id 17622762)1, 4, 9 Lamsa R....Soininen H. (Dement Geriatr Cogn Disord 2007)
    4. Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer's disease in Chinese. (PubMed id 16043284)1, 4, 9 Zhao F.G....Chan P. (Neurosci. Lett. 2005)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response. (PubMed id 20031551)1, 4 Voora D....Ginsburg G.S. (Circ Cardiovasc Genet 2008)
    7. The role of SOAT-1 polymorphisms in cognitive decline and delirium after bypass heart surgery. (PubMed id 17593314)1, 4 Tagarakis G....Papassotiropoulos A. (Clin Res Cardiol 2007)
    8. Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants. (PubMed id 16763159)1, 4 Klos K.L....Hixson J.E. (Arterioscler. Thromb. Vasc. Biol. 2006)
    9. A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. (PubMed id 16013913)1, 4 Papassotiropoulos A....Hock C. (J Clin Psychiatry 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6646 HGNC: 11177 AceView: SOAT1 Ensembl:ENSG00000057252 euGenes: HUgn6646
    ECgene: SOAT1 Kegg: 6646 H-InvDB: SOAT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SOAT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SOAT1 gene:
    Search GeneIP for patents involving SOAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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