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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SOAT1 Gene

protein-coding   GIFtS: 59
GCID: GC01P179262

sterol O-acyltransferase 1

(Previous name: sterol O-acyltransferase (acyl-Coenzyme A: cholesterol...)
(Previous symbols: SOAT, STAT)
 Explore 56 diseases affiliated with
SOAT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SOAT1    

Aliases
for SOAT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sterol O-Acyltransferase 11 2     ACACT2 3
ACAT1 2 3 5     ACAT-12 3
STAT1 2 3 5     ACAT12 3
SOAT1 2 3     EC 2.3.1.263 8
Sterol O-Acyltransferase (Acyl-Coenzyme A: Cholesterol Acyltransferase) 11 2     ACACT13
Acyl-Coenzyme A:Cholesterol Acyltransferase 12 3     Cholesterol Acyltransferase 13

External Ids:    HGNC: 111771   Entrez Gene: 66462   Ensembl: ENSG000000572527   OMIM: 1026425   UniProtKB: P356103   

Export aliases for SOAT1 gene to outside databases

Previous GC identifers: GC01P176787 GC01P174691 GC01P175783 GC01P176502 GC01P176453 GC01P175994 GC01P177529 GC01P150491


Summaries
for SOAT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SOAT1:
The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and
catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of
beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic
cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Nov
2011)

UniProtKB/Swiss-Prot: SOAT1_HUMAN, P35610
Function: Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary
cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase

summary for SOAT1:
Acyl-CoA: cholesterol acyltransferase (ACAT) is an ER-bound intracellular enzyme that forms cholesterol
esters from cholesterol. ACAT decreases the solubility of cholesterol and prevents its incorporation into
lipid membranes, and it is a vital enzyme in the biosynthesis of bile acids. However, ACAT also plays an
important role in foam cell formation and atherosclerosis due to cholesterol accumulation in macrophages.

Gene Wiki entry for SOAT1


Genomic Views
for SOAT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOAT1 gene promoter:
         TBP   C/EBPbeta   p53   TFIID   STAT3   IRF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SOAT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SOAT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SOAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25

SOAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOAT1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P179262:  view genomic region     (about GC identifiers)

Start:
 179,262,925 bp from pter      End:
 179,327,815 bp from pter
Size:
 64,891 bases      Orientation:
 plus strand

Proteins
for SOAT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SOAT1_HUMAN, P35610 (See protein sequence)
Recommended Name: Sterol O-acyltransferase 1  
Size: 550 amino acids; 64735 Da
Subunit: May form homo- or heterodimers
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: A6NC40 A8K3P4 A9Z1V7 B4DU95 Q5T0X4 Q8N1E4
Alternative splicing: 3 isoforms:  P35610-1   P35610-2   P35610-3   

Explore the universe of human proteins at neXtProt for SOAT1: NX_P35610

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35610

    • 4/14 DME Specific Peptides for SOAT1 (P35610) (see all 14)
     DWWNSTS  IVNDSRK  RRSLLDEL  YAFGKFPTV 

    SOAT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001239440.1  NP_001239441.1  NP_003092.4  

    ENSEMBL proteins: 
     ENSP00000356591   ENSP00000411309   ENSP00000445315   ENSP00000441356   ENSP00000442503  

    Human Recombinant Protein Products: 
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    Novus Biologicals SOAT1 Protein
    Novus Biologicals SOAT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SOAT1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA10623671
    GO:0005789endoplasmic reticulum membrane IDA17412327
    GO:0005792microsome ----
    GO:0016020membrane IDA9756919
    GO:0016021integral to membrane IEA--


    SOAT1 for ontologies           About GeneDecksing



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    Uscn Antibodies for SOAT1
    Search ThermoFisher Antibodies for SOAT1

    Assay Products for SOAT1: 
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    Uscn ELISAs and CLIAs for SOAT1

    Protein Domains /
    Families
    for SOAT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SOAT1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR014371 Oat_ACAT_DAG_ARE
     IPR004299 MBOAT_fam

    Graphical View of Domain Structure for InterPro Entry P35610

    ProtoNet protein and cluster: P35610

    1 Blocks protein family: IPB004299 Membrane bound O-acyl transferase

    UniProtKB/Swiss-Prot: SOAT1_HUMAN, P35610
    Similarity: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily


    Function
    for SOAT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SOAT1_HUMAN, P35610
    Function: Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary
    cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase
    Catalytic activity: Acyl-CoA + cholesterol = CoA + cholesterol ester
    Induction: Highly activated by the presence of cholesterol

    Enzyme Number (IUBMB): EC 2.3.1.261 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SOAT1
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate SOAT1 (see all 13):
    hsa-miR-2052 hsa-miR-548p hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-885-5p hsa-miR-141* hsa-miR-9 hsa-miR-19b-1*
    SwitchGear 3'UTR luciferase reporter plasmid: SOAT1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOAT1 (see all 7)
    OriGene shRNA RFP: SOAT1
    OriGene siRNA: SOAT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SOAT1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SOAT1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SOAT1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SOAT1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SOAT1 (NM_003101)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SOAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SOAT1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SOAT1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOAT1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000062fatty-acyl-CoA binding IDA16647063
    GO:0004772sterol O-acyltransferase activity IMP8407899
    GO:0008374O-acyltransferase activity ----
    GO:0015485cholesterol binding IDA16647063
    GO:0034736cholesterol O-acyltransferase activity IMP8407899


    SOAT1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for SOAT1: Soat1tm1Far Soat1tm1Ishi
         11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Soat1):
     cardiovascular system  cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  nervous system  tumorigenesis 
     vision/eye 

    SOAT1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SOAT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Statin Pathway, Pharmacodynamics
    		Statin Pathway, Pharmacodynamics1.00
    		Statin Pathway0.80
    2cholesterol biosynthesis III (via desmosterol)
    		Steroid biosynthesis0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SOAT1 
        Statin Pathway

    1 PharmGKB Pathway for SOAT1
        Statin Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for SOAT1):
        Steroid biosynthesis


    SOAT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SOAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for SOAT1 (P356102 ENSP000003565914) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CANXP278242MINT-8374864
    CELENSP000003611514STRING: ENSP00000361151
    DHCR24ENSP000003603164STRING: ENSP00000360316
    DHCR7ENSP000003477174STRING: ENSP00000347717
    LIPAENSP000003373544STRING: ENSP00000337354
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008203cholesterol metabolic process IMP8407899
    GO:0010742macrophage derived foam cell differentiation NAS18971559
    GO:0010878cholesterol storage IMP8407899
    GO:0033344cholesterol efflux IMP15308631
    GO:0034379very-low-density lipoprotein particle assembly IMP15308631


    SOAT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SOAT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SOAT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SOAT1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    YM 750Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor[138046-43-2]
    CI 976Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor[114289-47-3]
    VULM 1457Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor[228544-65-8]

    10/67 HMDB Compounds for SOAT1 (see all 67)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    2 DrugBank Compounds for SOAT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ezetimibe-- 163222-33-1targetinhibitor20227438 19669185 18442485
    HesperetinCyanidanon 4'-Methyl Ether 1626 (see all 3)520-33-2targetinhibitor15114505 11352979

    10/71 Novoseek chemical compound relationships for SOAT1 gene (see all 71)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    avasimibe 89.3 18 10634802 (3), 11853686 (2), 11427213 (2), 14644397 (2) (see all 12)
    pyripyropene a 86.4 6 8982343 (1), 13679053 (1), 18997389 (1), 15451793 (1)
    pactimibe 80.3 4 16554527 (1), 16824833 (1), 16730694 (1), 19293413 (1)
    tyrosine 78.6 197 10380880 (4), 8756628 (3), 10851052 (3), 14578356 (3) (see all 99)
    gp 130 77.6 17 10623831 (2), 7797460 (2), 18246092 (2), 9618263 (1) (see all 13)
    cholesterol ester 75.8 37 19644050 (2), 16172428 (2), 12520177 (1), 15063831 (1) (see all 18)
    cholesterol 70.2 366 8960784 (8), 8006519 (6), 12975367 (6), 8652654 (5) (see all 99)
    25-hydroxycholesterol 63.2 10 1630282 (2), 8652654 (1), 9559223 (1), 15317807 (1) (see all 7)
    sterol 60.3 33 12975367 (2), 15992359 (2), 9242919 (1), 14729857 (1) (see all 18)
    ifn-alpha 58.2 2 10777558 (1), 10470819 (1)

    Search CenterWatch for drugs/clinical trials and news about SOAT1 

    Transcripts
    for SOAT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SOAT1 gene (3 alternative transcripts): 
    NM_001252511.1  NM_001252512.1  NM_003101.5  

    Unigene Cluster for SOAT1:

    Sterol O-acyltransferase 1
    Hs.445588  [show with all ESTs]
    Unigene Representative Sequence: NM_003101
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367619(uc001gml.3 uc010pni.2 uc001gmm.3 uc010pnj.2 uc010pnk.2)
    ENST00000426956 ENST00000540564 ENST00000539888 ENST00000535686

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate SOAT1 (see all 13):
    hsa-miR-2052 hsa-miR-548p hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-885-5p hsa-miR-141* hsa-miR-9 hsa-miR-19b-1*
    SwitchGear 3'UTR luciferase reporter plasmid: SOAT1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SOAT1 (see all 7)
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SOAT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SOAT1

    Additional cDNA sequence: 

    AK026611.1 AK290659.1 AK294047.1 AK300551.1 AK310920.1 AK316401.1 AL833625.1 BC028940.1 
    L21934.2 NR_045530.1 

    16 DOTS entries:

    DT.100776222  DT.97821734  DT.100776223  DT.109635  DT.100025081  DT.411717  DT.121446664  DT.121446536 
    DT.121446475  DT.121446656  DT.40317182  DT.95307737  DT.95211062  DT.95225995  DT.95267467  DT.99979412 

    24/142 AceView cDNA sequences (see all 142):

    CK822097 BQ001792 BQ019926 BC028940 BQ887458 BG697850 NM_003101 BG674469 
    CR597057 BG697784 BP375996 BM992574 AW002840 BU625553 AA658096 AL710904 
    BG743201 CA309399 CB148519 AU154020 BU632602 CA488622 BX952510 R07296 

    GeneLoc Exon Structure


    Expression
    for SOAT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SOAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGATATTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SOAT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SOAT1

    SOURCE GeneReport for Unigene cluster: Hs.445588
        SABiosciences Expression via Pathway-Focused PCR Array including SOAT1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SOAT1

    Orthologs
    for SOAT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SOAT1 gene from 5/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SOAT11 sterol O-acyltransferase 1 69.61(n)
    70.72(a)    		   424424  XM_422267.3  XP_422267.3 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.114362 Transcribed sequence with moderate similarity to protein more 75.44(n)    AL876427.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5644241 novel protein similar to vertebrate sterol O-acyltransferase more 62.54(n)
    61.92(a)    		   564424  NM_001123272.1  NP_001116744.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG81121 , 3 sterol O-acyltransferase3
    CG81121    		 37(a)3
    45.64(n)1
    38.97(a)1    		   85A83
    410331  NM_141559.41  NP_649816.31 
    worm
    (Caenorhabditis elegans)    		 Secernentea B0395.23
    mboa-11    		 Sterol O-acyltransferase3
    Protein MBOA-11    		 35(a)3
    46.84(n)1
    35.55(a)1    		   X(16061623-16065478)3
    1816811  NM_078222.31  NP_510623.11 


    ENSEMBL Gene Tree for SOAT1 (if available)
    TreeFam Gene Tree for SOAT1 (if available) 

    Paralogs
    for SOAT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SOAT1 gene
    DGAT12  SOAT22  
    1 SIMAP similar gene for SOAT1 using alignment to 3 protein entries:     SOAT1_HUMAN (see all proteins):
    SOAT2

    SOAT1 for paralogs           About GeneDecksing



    Genomic Variants
    for SOAT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1352 NCBI SNPs in SOAT1 are shown (see all 1352)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs168538591,2
    		C,--150488587(+) GAAAAG/TGCCAG 4 -- us2k1 tfbs33Minor allele frequency- T:0.01NA 142
    rs767809171,2
    		F,--150488862(+) GCCAAG/AGGAAC 4 -- us2k11Minor allele frequency- A:0.03WA 118
    rs104945211,2
    		C,F,H,--150490509(-) GACTTG/AAGAGA 4 -- int118Minor allele frequency- A:0.01NS NA EA WA 1524
    rs585126931,2
    		C,--150490775(+) TTGAAA/CGGTTA 4 -- int12Minor allele frequency- C:0.04WA 120
    rs2006759271,2
    		C--150491253(+) TGAAGC/TTNNNN 4 -- int10--------
    rs760630241,2
    		--150491265(+) TTTTTC/ATTTTT 4 -- int11Minor allele frequency- A:0.50NA 2
    rs727155061,2
    		C,--150491551(+) GCTTCG/ATTTTC 4 -- int11Minor allele frequency- A:0.50NA 2
    rs596230891,2
    		C,--150491657(+) TATCAC/TTTCCT 4 -- int12Minor allele frequency- T:0.07WA 120
    rs1138143521,2
    		--150491797(+) GCCTGC/TTGTAA 4 -- int11Minor allele frequency- T:0.50CSA 2
    rs604590671,2
    		C,--150491941(+) GAAACA/GGAGTA 4 -- int12Minor allele frequency- G:0.17WA 120

    HapMap Linkage Disequilibrium report for SOAT1 (179262925 - 179327815 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SOAT1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SOAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for SOAT1

    Disorders / Diseases
    for SOAT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SOAT1 for disorders           About GeneDecksing

    OMIM gene information: 102642    OMIM disorders: --

    20/56 diseases for SOAT1 (see all 56):    About MalaCards
    cholesterol    insulin-like growth factor i deficiency    atherosclerosis    pulmonary alveolar proteinosis
    laron syndrome    inflammatory bowel disease    insulin resistance    hypercholesterolemia
    lymphoblastic leukemia    squamous cell carcinoma of the head and neck    lymphocytic leukemia    squamous cell carcinoma
    myeloid leukemia    familial hypercholesterolemia    acute lymphoblastic leukemia    chronic lymphocytic leukemia
    hepatitis c    acute myeloid leukemia    gallbladder adenocarcinoma    hyperlipidemia

    1 disease from the University of Copenhagen DISEASES database for SOAT1:
    Atherosclerosis

    10/56 Novoseek disease relationships for SOAT1 gene (see all 56)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 56.1 42 15699266 (2), 16820149 (2), 16180116 (2), 16554527 (1) (see all 34)
    atherosclerotic plaque 43.2 8 16824833 (2), 16554527 (1), 14615411 (1), 15961705 (1) (see all 7)
    leukemogenesis 43 8 12480704 (2), 19667270 (2)
    leukemia 39.2 20 10851048 (3), 14722044 (3), 12480704 (2), 19370975 (2) (see all 9)
    hypercholesterolemia 36.4 10 16462051 (1), 11290819 (1), 16141549 (1), 9247875 (1) (see all 8)
    chronic leukemia 31.9 2 10851048 (1), 11882364 (1)
    laron syndrome 27.8 2 10102076 (1)
    parainfluenza 26.3 2 17250865 (1), 15956600 (1)
    hyperlipidemia 26.2 7 15158756 (2), 16081263 (1), 17872457 (1), 15164335 (1) (see all 5)
    tumors 18.2 36 9662066 (2), 12438264 (2), 17497288 (2), 16264989 (2) (see all 29)

    Genetic Association Database (GAD): SOAT1
    Human Genome Epidemiology (HuGE) Navigator: SOAT1 (10 documents)

    Export disorders for SOAT1 gene to outside databases

    Publications
    for SOAT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SOAT1 gene, integrated from 9 sources (see all 626):
    (articles sorted by number of sources associating them with SOAT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. (PubMed id 8407899)1, 2, 3, 9 Chang C.C.Y.... Chang T.-Y. (1993)
    2. Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains. (PubMed id 10438503)1, 2, 9 Lin S.... Chang T.-Y. (1999)
    3. Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer's disease in Chinese. (PubMed id 16043284)1, 4, 9 Zhao F.G....Chan P. (2005)
    4. A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. (PubMed id 16013913)1, 4 Papassotiropoulos A....Hock C. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies. (PubMed id 15992359)1, 9 Liu J....Chang T.Y. (2005)
    7. Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus. (PubMed id 15319423)1, 9 Yang L....Chang T.Y. (2004)
    8. Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues. (PubMed id 10623671)1, 9 Sakashita N....Takahashi K. (2000)
    9. Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages. (PubMed id 18971559)1, 9 Kanome T....Miyazaki A. (2008)
    10. Expression of two isozymes of acyl-coenzyme A: cholesterol acyltransferase-1 and -2 in clear cell type renal cell carcinoma. (PubMed id 18269457)1, 9 Matsumoto K....Ueda S. (2008)

    External Searches for SOAT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing SOAT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6646 HGNC: 11177 AceView: SOAT1 Ensembl:ENSG00000057252 euGenes: HUgn6646
    ECgene: SOAT1 Kegg: 6646 H-InvDB: SOAT1

    Other Databases showing SOAT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SOAT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SOAT1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SOAT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SOAT1 gene:
    Search GeneIP for patents involving SOAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    for SOAT1 gene

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    About This Section

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