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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNX9 Gene

protein-coding   GIFtS: 58
GCID: GC06P158153

Sorting Nexin 9

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sorting Nexin 91 2     SDP12
SH3PX12 3 5     WISP2
SH3PXD3A2 3     Sorting Nexin-92
SH3 And PX Domain-Containing Protein 12 3     Wiskott-Aldrich Syndrome Protein (WASP) Interactor Protein2
SH3 And PX Domain-Containing Protein 3A2 3     Protein SDP13

External Ids:    HGNC: 149731   Entrez Gene: 514292   Ensembl: ENSG000001303407   OMIM: 6059525   UniProtKB: Q9Y5X13   

Export aliases for SNX9 gene to outside databases

Previous GC identifers: GC06P157685 GC06P158117 GC06P158110 GC06P155760


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNX9 Gene:
This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding
domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region,
like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is
reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase
non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is
implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin
nucleation. (provided by RefSeq, Jul 2013)

GeneCards Summary for SNX9 Gene: 
SNX9 (sorting nexin 9) is a protein-coding gene. Diseases associated with SNX9 include wiskott-aldrich syndrome, and choanal atresia, and among its related super-pathways are Golgi Associated Vesicle Biogenesis and Clathrin-dependent protein traffic. GO annotations related to this gene include protein homodimerization activity and 1-phosphatidylinositol binding. An important paralog of this gene is SNX33.

UniProtKB/Swiss-Prot: SNX9_HUMAN, Q9Y5X1
Function: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via
clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in
macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates
the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL,
and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in
phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched
in phosphatidylinositol 3-phosphate

Gene Wiki entry for SNX9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNX9 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNX9 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNX9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1-q26   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.1-q26

SNX9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P158153:  view genomic region     (about GC identifiers)

Start:
158,244,294 bp from pter      End:
158,366,109 bp from pter
Size:
121,816 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNX9_HUMAN, Q9Y5X1 (See protein sequence)
Recommended Name: Sorting nexin-9  
Size: 595 amino acids; 66592 Da
Subunit: Homodimer, and homooligomer. Heterodimer with SNX18. Interacts with ITCH. Interacts (via SH3 domain) with
TNK2, WASL and ARP3. Identified in a complex with TNK2 and clathrin heavy chains. Identified in a complex with
the AP-2 complex, clathrin and DNM2. Interacts (via SH3 domain) with DNM1 and DNM2. Identified in an oligomeric
complex containing DNM1 and SNX9. Interacts with ADAM9 and ADAM15 cytoplasmic tails
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane;
Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus,
trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell
membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage
of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane
6 PDB 3D structures from and Proteopedia for SNX9:
2RAI (3D)        2RAJ (3D)        2RAK (3D)        3DYT (3D)        3DYU (3D)        3LGE (3D)    
Secondary accessions: Q9BSI7 Q9BVM1 Q9UJH6 Q9UP20

Explore the universe of human proteins at neXtProt for SNX9: NX_Q9Y5X1

Explore proteomics data for SNX9 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by ITCH
  • UniProtKB: Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5X1

  • SNX9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNX9 Protein Expression
    REFSEQ proteins: NP_057308.1  
    ENSEMBL proteins: 
     ENSP00000376024  
    Reactome Protein details: Q9Y5X1
    Human Recombinant Protein Products for SNX9: 
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    Cloud-Clone Corp. Proteins for SNX9 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network IDA15703209
    GO:0005886plasma membrane ----

    SNX9 for ontologies           About GeneDecksing



    SNX9 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SNX: Sorting nexins

    4 InterPro protein domains:
     IPR001452 SH3_domain
     IPR019497 Sorting_nexin_WASP-bd-dom
     IPR001683 Phox
     IPR014536 Snx9

    Graphical View of Domain Structure for InterPro Entry Q9Y5X1

    ProtoNet protein and cluster: Q9Y5X1

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001683 Phox-like


    UniProtKB/Swiss-Prot: SNX9_HUMAN, Q9Y5X1
    Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol phosphate. Has high
    affinity for phosphatidylinositol 4,5-bisphosphate, but can also bind to membranes enriched in other
    phosphatidylinositol phosphates
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 1 SH3 domain


    SNX9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNX9_HUMAN, Q9Y5X1
    Function: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via
    clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in
    macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates
    the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL,
    and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in
    phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched
    in phosphatidylinositol 3-phosphate

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10531379
    GO:00055451-phosphatidylinositol binding IDA17948057
    GO:0031625ubiquitin protein ligase binding IPI--
    GO:0035091phosphatidylinositol binding ----
    GO:0042803protein homodimerization activity IPI17948057
         
    SNX9 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SNX9:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNX9 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNX9 
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    SwitchGear 3'UTR luciferase reporter plasmidSNX9 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SNX9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    2Clathrin-dependent protein traffic
    Transport Clathrin-coated vesicle cycle0.66
    wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)0.35
    3Membrane Trafficking
    Membrane Trafficking0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for SNX9
        wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle


    4        Reactome Pathways for SNX9
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding



    SNX9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNX9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for SNX9 (Q9Y5X11, 2, 3 ENSP000003760244) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3, ENSP000003639984MINT-7889571 MINT-7889591 MINT-7889673 MINT-7890033 MINT-7889610 MINT-7889619 MINT-7889689 I2D: score=2 STRING: ENSP00000363998
    DNM2P505702, 3, ENSP000003527214MINT-61335 MINT-61336 MINT-7302047 MINT-7301992 MINT-61334 MINT-61332 I2D: score=4 STRING: ENSP00000352721
    SYNJ1O434262, 3, ENSP000003222344MINT-62869 MINT-62867 MINT-62870 MINT-62871 I2D: score=1 STRING: ENSP00000322234
    ASAP1Q9ULH12, 3, ENSP000003502974MINT-7145899 MINT-7145843 I2D: score=1 STRING: ENSP00000350297
    ADAM15Q134442, 3, ENSP000003494364MINT-2792432 I2D: score=5 STRING: ENSP00000349436
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IMP--
    GO:0006886intracellular protein transport IMP15703209
    GO:0006897endocytosis IMP--
    GO:0006898receptor-mediated endocytosis IMP15703209
    GO:0007067mitosis IEA--

    SNX9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNX9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNX9

    1 Novoseek inferred chemical compound relationship for SNX9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 6.69 11 16316319 (3), 11799118 (2), 16137687 (1)

    Search CenterWatch for drugs/clinical trials and news about SNX9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNX9 gene: 
    NM_016224.4  

    Unigene Cluster for SNX9:

    Sorting nexin 9
    Hs.191213  [show with all ESTs]
    Unigene Representative Sequence: AB209736
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000392185(uc003qqv.1)
    miRNA
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    Additional mRNA sequence: 

    AB209736.1 AF076957.1 AF121859.1 AF131214.1 AF172847.1 AF190158.1 AJ420452.1 AJ420512.1 
    AK026637.1 AK127345.1 AK314360.1 BC001084.2 BC005022.1 

    16 DOTS entries:

    DT.95093204  DT.92434771  DT.91868182  DT.92434756  DT.100826247  DT.100826248  DT.121319387  DT.40126285 
    DT.100726479  DT.91991058  DT.92434773  DT.97859333  DT.121319340  DT.92434753  DT.86859790  DT.91749225 

    24/314 AceView cDNA sequences (see all 314):

    D78911 T80767 AI420462 BQ949568 CB157071 CA446384 AL040799 AA371061 
    CB322039 CB126588 AA455006 BM561256 AI038583 AA865811 NM_016224 AI025222 
    T32773 AA446880 BQ447996 BU734888 CR624899 AI439264 AA313675 AI244405 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNX9 expression in normal human tissues (normalized intensities)      SNX9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAGCCAA
    SNX9 Expression
    About this image


    SNX9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus

    See SNX9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNX9

    SOURCE GeneReport for Unigene cluster: Hs.191213

    UniProtKB/Swiss-Prot: SNX9_HUMAN, Q9Y5X1
    Tissue specificity: Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and
    peripheral blood leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SNX9 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snx91 , 5 sorting nexin 91, 5 87.37(n)1
    90.91(a)1
      17 (3.51 cM)5
    666161  NM_025664.51  NP_079940.21 
     58413805 
    chicken
    (Gallus gallus)
    Aves SNX91 sorting nexin 9 80.65(n)
    86.29(a)
      421654  XM_419693.3  XP_419693.2 
    lizard
    (Anolis carolinensis)
    Reptilia SNX96
    sorting nexin 9
    78(a)
    1 ↔ 1
    1(213106074-213143641)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.187022 Xenopus laevis transcribed sequence with moderate similarity more 80.23(n)    BI443849.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570939902   -- 72.53(n)    57093990 
    fruit fly
    (Drosophila melanogaster)
    Insecta SH3PX13 intracellular protein transport 32(a)   67C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea lst-46
    Protein LST-4, isoform d
    24(a)
    1 → many
    IV(14061005-14069856)


    ENSEMBL Gene Tree for SNX9 (if available)
    TreeFam Gene Tree for SNX9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNX9 gene
    SNX332  SNX182  
    4 SIMAP similar genes for SNX9 using alignment to 1 protein entry:     SNX9_HUMAN:
    WISP    SH3GL2    SNX33    SNX18

    SNX9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2677 SNPs in SNX9 are shown (see all 2677)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28033561,2
    C,H--158242549(+) TCATAC/TATACA 1 -- us2k111Minor allele frequency- T:0.02NA WA CSA EA 372
    rs132020171,2
    C,F,H--158242573(+) TCTGAC/AAACAG 1 -- us2k118Minor allele frequency- A:0.15NS EA NA WA 2228
    rs1178184681,2
    F--158242611(+) TCTAGG/CAATGT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs678388641,2
    C--158242630(+) TTTCC-/T/TTTT
            
    TTTTT
    1 -- us2k10--------
    rs345172941,2
    C--158242731(+) TAGTA-/TTTTTG 1 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs1808468591,2
    --158242778(+) GTTAAC/TAAACA 1 -- us2k10--------
    rs357707361,2
    C,F,H--158242794(+) GTTGCT/CTTCTG 1 -- us2k119Minor allele frequency- C:0.22NS EA NA WA CSA 2054
    rs354249801,2
    C,F--158242874(+) ATTCCC/TAGGAG 1 -- us2k17Minor allele frequency- T:0.28NA WA CSA 246
    rs356020441,2
    C,F--158242879(+) CAGGAG/AGGCTG 1 -- us2k16Minor allele frequency- A:0.27NA WA CSA 245
    rs735738091,2
    C,F--158242901(+) GCTACG/AGTCAT 1 -- us2k17Minor allele frequency- A:0.28NA WA CSA 247

    HapMap Linkage Disequilibrium report for SNX9 (158244294 - 158366109 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SNX9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2732987CNV Deletion23290073
    esv2732990CNV Deletion23290073
    esv2732989CNV Deletion23290073
    esv2732988CNV Deletion23290073
    esv2661273CNV Deletion23128226
    esv2732986CNV Deletion23290073
    esv272751CNV Insertion20981092
    nsv518831CNV Loss19592680
    nsv5558CNV Loss18451855
    nsv823888CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605952    OMIM disorders: --

    6 diseases for SNX9:    About MalaCards
    wiskott-aldrich syndrome    choanal atresia    rabies    asthma
    alcoholism    neuronitis


    SNX9 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SNX9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 66.6 3 17242350 (1), 17220534 (1), 20427313 (1)

    Genetic Association Database (GAD): SNX9
    Human Genome Epidemiology (HuGE) Navigator: SNX9 (2 documents)

    Export disorders for SNX9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNX9 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with SNX9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. (PubMed id 17609109)1, 2, 3, 9 Yarar D....Schmid S.L. (2007)
    2. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. (PubMed id 10531379)1, 2, 3 Howard L.... Blobel C.P. (1999)
    3. The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. (PubMed id 11799118)1, 2, 9 Lin Q....Yang W. (2002)
    4. Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. (PubMed id 12952949)1, 2, 9 Lundmark R. and Carlsson S.R. (2003)
    5. Mechanism of aldolase control of sorting nexin 9 func tion in endocytosis. (PubMed id 20129922)1, 2, 9 Rangarajan E.S....Izard T. (2010)
    6. SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2. (PubMed id 18388313)1, 2, 9 Shin N....Chang S. (2008)
    7. Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2. (PubMed id 16316319)1, 2, 9 Childress C....Yang W. (2006)
    8. SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. (PubMed id 16137687)1, 2, 9 Yeow-Fong L....Manser E. (2005)
    9. SNX9 regulates dynamin assembly and is required for e fficient clathrin-mediated endocytosis. (PubMed id 15703209)1, 2, 9 Soulet F....Schmid S.L. (2005)
    10. Structure and plasticity of Endophilin and Sorting Nexin 9. (PubMed id 18940612)1, 2, 9 Wang Q....Sondermann H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51429 HGNC: 14973 AceView: SNX9 Ensembl:ENSG00000130340 euGenes: HUgn51429
    ECgene: SNX9 H-InvDB: SNX9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNX9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNX9 gene:
    Search GeneIP for patents involving SNX9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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