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SNX9 Gene

protein-coding   GIFtS: 60
GCID: GC06P158153

Sorting Nexin 9

  See SNX9-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sorting Nexin 91 2     SDP12
SH3PX12 3 5     WISP2
SH3PXD3A2 3     Sorting Nexin-92
SH3 And PX Domain-Containing Protein 12 3     Wiskott-Aldrich Syndrome Protein (WASP) Interactor Protein2
SH3 And PX Domain-Containing Protein 3A2 3     Protein SDP13

External Ids:    HGNC: 149731   Entrez Gene: 514292   Ensembl: ENSG000001303407   OMIM: 6059525   UniProtKB: Q9Y5X13   

Export aliases for SNX9 gene to outside databases

Previous GC identifers: GC06P157685 GC06P158117 GC06P158110 GC06P155760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNX9 Gene:
This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding
domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region,
like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is
reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase
non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is
implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin
nucleation. (provided by RefSeq, Jul 2013)

GeneCards Summary for SNX9 Gene:
SNX9 (sorting nexin 9) is a protein-coding gene. Diseases associated with SNX9 include wiskott-aldrich syndrome. GO annotations related to this gene include protein homodimerization activity and 1-phosphatidylinositol binding. An important paralog of this gene is SNX33.

UniProtKB/Swiss-Prot: SNX9_HUMAN, Q9Y5X1
Function: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of
mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the
cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also
clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes
internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of
DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role
in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol
4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in
phosphatidylinositol 3-phosphate

Gene Wiki entry for SNX9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNX9 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNX9 promoter sequence
   Search Chromatin IP Primers for SNX9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNX9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1-q26   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.1-q26

SNX9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P158153:  view genomic region     (about GC identifiers)

Start:
158,244,294 bp from pter      End:
158,366,109 bp from pter
Size:
121,816 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SNX9_HUMAN, Q9Y5X1 (See protein sequence)
Recommended Name: Sorting nexin-9  
Size: 595 amino acids; 66592 Da
Subunit: Homodimer, and homooligomer. Heterodimer with SNX18. Interacts with ITCH. Interacts (via SH3 domain) with
TNK2, WASL and ARP3. Identified in a complex with TNK2 and clathrin heavy chains. Identified in a complex with
the AP-2 complex, clathrin and DNM2. Interacts (via SH3 domain) with DNM1 and DNM2. Identified in an oligomeric
complex containing DNM1 and SNX9. Interacts with ADAM9 and ADAM15 cytoplasmic tails
6 PDB 3D structures from and Proteopedia for SNX9:
2RAI (3D)        2RAJ (3D)        2RAK (3D)        3DYT (3D)        3DYU (3D)        3LGE (3D)    
Secondary accessions: Q9BSI7 Q9BVM1 Q9UJH6 Q9UP20

Explore the universe of human proteins at neXtProt for SNX9: NX_Q9Y5X1

Explore proteomics data for SNX9 at MOPED

Post-translational modifications: 

  • Ubiquitinated by ITCH1
  • Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR1
  • Ubiquitination2 at Lys223
  • Modification sites at PhosphoSitePlus

  • See SNX9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057308.1  
    ENSEMBL proteins: 
     ENSP00000376024  
    Reactome Protein details: Q9Y5X1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SNX: Sorting nexins

    5 InterPro protein domains:
     IPR001452 SH3_domain
     IPR019497 Sorting_nexin_WASP-bd-dom
     IPR028644 SNX9
     IPR001683 Phox
     IPR014536 Snx9_subfam

    Graphical View of Domain Structure for InterPro Entry Q9Y5X1

    ProtoNet protein and cluster: Q9Y5X1

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001683 Phox-like


    UniProtKB/Swiss-Prot: SNX9_HUMAN, Q9Y5X1
    Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol phosphate. Has high
    affinity for phosphatidylinositol 4,5-bisphosphate, but can also bind to membranes enriched in other
    phosphatidylinositol phosphates
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with SNX9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNX9_HUMAN, Q9Y5X1
    Function: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of
    mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the
    cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also
    clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes
    internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of
    DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role
    in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol
    4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in
    phosphatidylinositol 3-phosphate

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10531379
    GO:00055451-phosphatidylinositol binding IDA17948057
    GO:0031625ubiquitin protein ligase binding IPI--
    GO:0035091phosphatidylinositol binding ----
    GO:0042803protein homodimerization activity IPI17948057
         
    Find genes that share ontologies with SNX9           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SNX9:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNX9
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNX9

    miRNA
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    Block miRNA regulation of human, mouse, rat SNX9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX9 (see all 77):
    hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidSNX9 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNX9_HUMAN, Q9Y5X1: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane;
    Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus,
    trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell
    membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage
    of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    golgi apparatus3
    nucleus2
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IBA--
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network IDA15703209

    Find genes that share ontologies with SNX9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNX9 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32
    2Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    wtCFTR and delta508 traffic Clathrin coated vesicles formation norm and CF 0.35


    Find genes that share SuperPaths with SNX9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for SNX9
        wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle


    1 Reactome Pathway for SNX9
        Golgi Associated Vesicle Biogenesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNX9
    Interactions:

        GeneGlobe Interaction Network for SNX9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNX9 (Q9Y5X11, 2, 3 ENSP000003760244) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J021, 2, 3, ENSP000003639984EBI-77848,EBI-1564678 MINT-7889571 MINT-7889591 MINT-7889673 MINT-7890033 MINT-7889610 MINT-7889619 MINT-7889689 I2D: score=2 STRING: ENSP00000363998
    DNM2P505701, 2, 3, ENSP000003527214EBI-77848,EBI-346547 MINT-61335 MINT-61336 MINT-7302047 MINT-7301992 MINT-61334 MINT-61332 I2D: score=4 STRING: ENSP00000352721
    ADAM15Q134441, 2, 3, ENSP000003494364EBI-77848,EBI-77818 MINT-2792432 I2D: score=5 STRING: ENSP00000349436
    SYNJ1O434262, 3, ENSP000003222344MINT-62869 MINT-62867 MINT-62870 MINT-62871 I2D: score=1 STRING: ENSP00000322234
    ASAP1Q9ULH12, 3, ENSP000003502974MINT-7145899 MINT-7145843 I2D: score=1 STRING: ENSP00000350297
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IMP--
    GO:0006886intracellular protein transport IMP15703209
    GO:0006897endocytosis IMP--
    GO:0006898receptor-mediated endocytosis IMP15703209
    GO:0007067mitosis IEA--

    Find genes that share ontologies with SNX9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNX9

    1 Novoseek inferred chemical compound relationship for SNX9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 6.69 11 16316319 (3), 11799118 (2), 16137687 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNX9 gene: 
    NM_016224.4  

    Unigene Cluster for SNX9:

    Sorting nexin 9
    Hs.191213  [show with all ESTs]
    Unigene Representative Sequence: AB209736
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000392185(uc003qqv.1)
    miRNA
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    hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-3653
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    Additional mRNA sequence: 

    AB209736.1 AF076957.1 AF121859.1 AF131214.1 AF172847.1 AF190158.1 AJ420452.1 AJ420512.1 
    AK026637.1 AK127345.1 AK314360.1 BC001084.2 BC005022.1 

    16 DOTS entries:

    DT.95093204  DT.92434771  DT.91868182  DT.92434756  DT.100826247  DT.100826248  DT.121319387  DT.40126285 
    DT.100726479  DT.91991058  DT.92434773  DT.97859333  DT.121319340  DT.92434753  DT.86859790  DT.91749225 

    Selected AceView cDNA sequences (see all 314):

    D78911 T80767 AI420462 BQ949568 CB157071 CA446384 AL040799 AA371061 
    CB322039 CB126588 AA455006 BM561256 AI038583 AA865811 NM_016224 AI025222 
    T32773 AA446880 BQ447996 BU734888 CR624899 AI439264 AA313675 AI244405 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNX9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAGCCAA
    SNX9 Expression
    About this image


    SNX9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
    SNX9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNX9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191213

    UniProtKB/Swiss-Prot: SNX9_HUMAN, Q9Y5X1
    Tissue specificity: Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and
    peripheral blood leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SNX9 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snx91 , 5 sorting nexin 91, 5 87.37(n)1
    90.91(a)1
      17 (3.51 cM)5
    666161  NM_025664.51  NP_079940.21 
     58413805 
    chicken
    (Gallus gallus)
    Aves SNX91 sorting nexin 9 80.32(n)
    85.62(a)
      421654  XM_004935661.1  XP_004935718.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNX96
    sorting nexin 9
    78(a)
    1 ↔ 1
    1(213106074-213143641)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.187022 Xenopus laevis transcribed sequence with moderate similarity more 80.23(n)    BI443849.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570939902   -- 72.53(n)    57093990 
    fruit fly
    (Drosophila melanogaster)
    Insecta SH3PX13 intracellular protein transport 32(a)   67C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea lst-46
    Protein LST-4, isoform a
    26(a)
    1 → many
    IV(14061005-14069854) WBGene00003086


    ENSEMBL Gene Tree for SNX9 (if available)
    TreeFam Gene Tree for SNX9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNX9 gene
    SNX332  SNX182  
    4 SIMAP similar genes for SNX9 using alignment to 1 protein entry:     SNX9_HUMAN:
    WISP    SH3GL2    SNX33    SNX18

    Find genes that share paralogs with SNX9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNX9 (see all 2677)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28033561,2
    C,H--158242549(+) TCATAC/TATACA 1 -- us2k111Minor allele frequency- T:0.02NA WA CSA EA 372
    rs132020171,2
    C,F,H--158242573(+) TCTGAC/AAACAG 1 -- us2k118Minor allele frequency- A:0.15NS EA NA WA 2228
    rs1178184681,2
    F--158242611(+) TCTAGG/CAATGT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs678388641,2
    C--158242630(+) TTTCC-/T/TTTT
            
    TTTTT
    1 -- us2k10--------
    rs345172941,2
    C--158242731(+) TAGTA-/TTTTTG 1 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs1808468591,2
    --158242778(+) GTTAAC/TAAACA 1 -- us2k10--------
    rs357707361,2
    C,F,H--158242794(+) GTTGCT/CTTCTG 1 -- us2k119Minor allele frequency- C:0.22NS EA NA WA CSA 2054
    rs354249801,2
    C,F--158242874(+) ATTCCC/TAGGAG 1 -- us2k17Minor allele frequency- T:0.28NA WA CSA 246
    rs356020441,2
    C,F--158242879(+) CAGGAG/AGGCTG 1 -- us2k16Minor allele frequency- A:0.27NA WA CSA 245
    rs735738091,2
    C,F--158242901(+) GCTACG/AGTCAT 1 -- us2k17Minor allele frequency- A:0.28NA WA CSA 247

    HapMap Linkage Disequilibrium report for SNX9 (158244294 - 158366109 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SNX9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732987CNV Deletion23290073
    esv2732990CNV Deletion23290073
    esv2732989CNV Deletion23290073
    esv2732988CNV Deletion23290073
    esv2661273CNV Deletion23128226
    esv2732986CNV Deletion23290073
    esv272751CNV Insertion20981092
    nsv518831CNV Loss19592680
    nsv5558CNV Loss18451855
    nsv823888CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNX9
    DNA2.0 Custom Variant and Variant Library Synthesis for SNX9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605952    OMIM disorders: --

    1 disease for SNX9:    
    About MalaCards
    wiskott-aldrich syndrome


    Find genes that share disorders with SNX9           About GenesLikeMe

    1 Novoseek inferred disease relationship for SNX9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 66.6 3 17242350 (1), 17220534 (1), 20427313 (1)

    Genetic Association Database (GAD): SNX9
    Human Genome Epidemiology (HuGE) Navigator: SNX9 (2 documents)

    Export disorders for SNX9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNX9 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with SNX9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. (PubMed id 17609109)1, 2, 3, 9 Yarar D.... Schmid S.L. (Dev. Cell 2007)
    2. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. (PubMed id 10531379)1, 2, 3 Howard L.... Blobel C.P. (J. Biol. Chem. 1999)
    3. The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. (PubMed id 11799118)1, 2, 9 Lin Q.... Yang W. (J. Biol. Chem. 2002)
    4. Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. (PubMed id 12952949)1, 2, 9 Lundmark R. and Carlsson S.R. (J. Biol. Chem. 2003)
    5. Mechanism of aldolase control of sorting nexin 9 function in endocytosis. (PubMed id 20129922)1, 2, 9 Rangarajan E.S.... Izard T. (J. Biol. Chem. 2010)
    6. SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2. (PubMed id 18388313)1, 2, 9 Shin N.... Chang S. (J. Cell Sci. 2008)
    7. Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2. (PubMed id 16316319)1, 2, 9 Childress C.... Yang W. (Biochem. J. 2006)
    8. SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. (PubMed id 16137687)1, 2, 9 Yeow-Fong L.... Manser E. (FEBS Lett. 2005)
    9. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. (PubMed id 15703209)1, 2, 9 Soulet F.... Schmid S.L. (Mol. Biol. Cell 2005)
    10. Structure and plasticity of Endophilin and Sorting Nexin 9. (PubMed id 18940612)1, 2, 9 Wang Q.... Sondermann H. (Structure 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51429 HGNC: 14973 AceView: SNX9 Ensembl:ENSG00000130340 euGenes: HUgn51429
    ECgene: SNX9 H-InvDB: SNX9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SNX9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SNX9 gene:
    Search GeneIP for patents involving SNX9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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