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Aliases for SNX9 Gene

Aliases for SNX9 Gene

  • Sorting Nexin 9 2 3
  • SH3PX1 3 4 6
  • SH3 And PX Domain-Containing Protein 3A 3 4
  • SH3 And PX Domain-Containing Protein 1 3 4
  • SH3PXD3A 3 4
  • Wiskott-Aldrich Syndrome Protein (WASP) Interactor Protein 3
  • Sorting Nexin-9 3
  • Protein SDP1 4
  • SDP1 3
  • WISP 3

External Ids for SNX9 Gene

Previous GeneCards Identifiers for SNX9 Gene

  • GC06P158117
  • GC06P158153
  • GC06P158110
  • GC06P155760

Summaries for SNX9 Gene

Entrez Gene Summary for SNX9 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]

GeneCards Summary for SNX9 Gene

SNX9 (Sorting Nexin 9) is a Protein Coding gene. Diseases associated with SNX9 include wiskott-aldrich syndrome. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include protein homodimerization activity and 1-phosphatidylinositol binding. An important paralog of this gene is SNX18.

UniProtKB/Swiss-Prot for SNX9 Gene

  • Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.

Gene Wiki entry for SNX9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX9 Gene

Genomics for SNX9 Gene

Regulatory Elements for SNX9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNX9 Gene

Start:
157,700,387 bp from pter
End:
157,945,077 bp from pter
Size:
244,691 bases
Orientation:
Plus strand

Genomic View for SNX9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX9 Gene

Proteins for SNX9 Gene

  • Protein details for SNX9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5X1-SNX9_HUMAN
    Recommended name:
    Sorting nexin-9
    Protein Accession:
    Q9Y5X1
    Secondary Accessions:
    • Q9BSI7
    • Q9BVM1
    • Q9UJH6
    • Q9UP20

    Protein attributes for SNX9 Gene

    Size:
    595 amino acids
    Molecular mass:
    66592 Da
    Quaternary structure:
    • Homodimer, and homooligomer. Heterodimer with SNX18. Interacts with ITCH. Interacts (via SH3 domain) with TNK2, WASL and ARP3. Identified in a complex with TNK2 and clathrin heavy chains. Identified in a complex with the AP-2 complex, clathrin and DNM2. Interacts (via SH3 domain) with DNM1 and DNM2. Identified in an oligomeric complex containing DNM1 and SNX9. Interacts with ADAM9 and ADAM15 cytoplasmic tails.

    Three dimensional structures from OCA and Proteopedia for SNX9 Gene

neXtProt entry for SNX9 Gene

Proteomics data for SNX9 Gene at MOPED

Post-translational modifications for SNX9 Gene

  • Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR
  • Ubiquitinated by ITCH.
  • Ubiquitination at Lys223
  • Modification sites at PhosphoSitePlus

Other Protein References for SNX9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SNX9 Gene

Domains for SNX9 Gene

Gene Families for SNX9 Gene

HGNC:
  • SNX :Sorting nexins

Protein Domains for SNX9 Gene

Suggested Antigen Peptide Sequences for SNX9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5X1

UniProtKB/Swiss-Prot:

SNX9_HUMAN :
  • Q9Y5X1
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol phosphate. Has high affinity for phosphatidylinositol 4,5-bisphosphate, but can also bind to membranes enriched in other phosphatidylinositol phosphates.
  • Contains 1 BAR domain.
  • Contains 1 PX (phox homology) domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX9: view

Function for SNX9 Gene

Molecular function for SNX9 Gene

UniProtKB/Swiss-Prot Function:
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.

Gene Ontology (GO) - Molecular Function for SNX9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10531379
GO:0005545 1-phosphatidylinositol binding IDA 17948057
GO:0031625 ubiquitin protein ligase binding IPI 20491914
GO:0035091 phosphatidylinositol binding IDA 18388313
GO:0042803 protein homodimerization activity IPI 17948057
genes like me logo Genes that share ontologies with SNX9: view
genes like me logo Genes that share phenotypes with SNX9: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNX9 Gene

Localization for SNX9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX9 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX9 Gene COMPARTMENTS Subcellular localization image for SNX9 gene
Compartment Confidence
plasma membrane 5
cytosol 3
golgi apparatus 3
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for SNX9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005737 cytoplasm IDA --
GO:0005768 endosome IBA --
GO:0005802 trans-Golgi network IDA 15703209
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with SNX9: view

Pathways for SNX9 Gene

genes like me logo Genes that share pathways with SNX9: view

Gene Ontology (GO) - Biological Process for SNX9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 22718350
GO:0006886 intracellular protein transport IMP 15703209
GO:0006897 endocytosis IMP 22718350
GO:0006898 receptor-mediated endocytosis IMP 15703209
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with SNX9: view

Compounds for SNX9 Gene

(1) Novoseek inferred chemical compound relationships for SNX9 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 6.69 6
genes like me logo Genes that share compounds with SNX9: view

Transcripts for SNX9 Gene

Unigene Clusters for SNX9 Gene

Sorting nexin 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX9

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX9 Gene

No ASD Table

Relevant External Links for SNX9 Gene

GeneLoc Exon Structure for
SNX9
ECgene alternative splicing isoforms for
SNX9

Expression for SNX9 Gene

mRNA expression in normal human tissues for SNX9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SNX9 Gene

This gene is overexpressed in Cervix (9.8), Lymph node (8.4), and Islet of Langerhans (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX9 Gene

SOURCE GeneReport for Unigene cluster for SNX9 Gene Hs.191213

mRNA Expression by UniProt/SwissProt for SNX9 Gene

Q9Y5X1-SNX9_HUMAN
Tissue specificity: Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes.
genes like me logo Genes that share expressions with SNX9: view

Expression partners for SNX9 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SNX9 Gene

Orthologs for SNX9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNX9 35
  • 89.49 (n)
  • 93.25 (a)
SNX9 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX9 35
  • 89.6 (n)
  • 93.25 (a)
SNX9 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx9 35
  • 87.37 (n)
  • 90.91 (a)
Snx9 16
Snx9 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNX9 35
  • 99.66 (n)
  • 100 (a)
SNX9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx9 35
  • 87.15 (n)
  • 91.75 (a)
oppossum
(Monodelphis domestica)
Mammalia SNX9 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX9 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX9 35
  • 80.32 (n)
  • 85.62 (a)
SNX9 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX9 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx9 35
  • 72.78 (n)
  • 76.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18702 35
zebrafish
(Danio rerio)
Actinopterygii snx9b 35
  • 67.76 (n)
  • 67.82 (a)
snx9a 36
  • 59 (a)
OneToMany
snx9b 36
  • 66 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1038 35
fruit fly
(Drosophila melanogaster)
Insecta SH3PX1 37
  • 32 (a)
SH3PX1 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lst-4 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for SNX9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX9 Gene

ENSEMBL:
Gene Tree for SNX9 (if available)
TreeFam:
Gene Tree for SNX9 (if available)

Paralogs for SNX9 Gene

Paralogs for SNX9 Gene

Selected SIMAP similar genes for SNX9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SNX9: view

Variants for SNX9 Gene

Sequence variations from dbSNP and Humsavar for SNX9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs577 -- 157,944,003(+) CTTCC(C/T)GACTA utr-variant-3-prime
rs15371 -- 157,944,076(-) TTTTG(A/C)TTTAT utr-variant-3-prime
rs168455 -- 157,773,121(-) AAACA(C/T)GAAAC intron-variant
rs181275 -- 157,779,546(-) TCTGC(A/G)TAGAC intron-variant
rs183030 -- 157,771,845(-) gtggg(C/T)gcctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX9 Gene

Variant ID Type Subtype PubMed ID
nsv823888 CNV Gain 20364138
esv272751 CNV Insertion 20981092
esv2732986 CNV Deletion 23290073
esv2732987 CNV Deletion 23290073
esv2732988 CNV Deletion 23290073
esv2732989 CNV Deletion 23290073
esv2732990 CNV Deletion 23290073
nsv5558 CNV Loss 18451855
esv2661273 CNV Deletion 23128226
nsv518831 CNV Loss 19592680

Relevant External Links for SNX9 Gene

HapMap Linkage Disequilibrium report
SNX9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX9 Gene

Disorders for SNX9 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SNX9 Gene in MalaCards »

(1) Diseases for SNX9 Gene including...

(1) Novoseek inferred disease relationships for SNX9 Gene

Disease -log(P) Hits PubMed IDs
wiskott-aldrich syndrome 66.6 3

Relevant External Links for SNX9

Genetic Association Database (GAD)
SNX9
Human Genome Epidemiology (HuGE) Navigator
SNX9
genes like me logo Genes that share disorders with SNX9: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SNX9 Gene

Publications for SNX9 Gene

  1. SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. (PMID: 17609109) Yarar D. … Schmid S.L. (Dev. Cell 2007) 2 3 4 23
  2. The PX-BAR membrane-remodeling unit of sorting nexin 9. (PMID: 17948057) Pylypenko O. … Rak A. (EMBO J. 2007) 3 4 23
  3. The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. (PMID: 11799118) Lin Q. … Yang W. (J. Biol. Chem. 2002) 3 4 23
  4. Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. (PMID: 12952949) Lundmark R. … Carlsson S.R. (J. Biol. Chem. 2003) 3 4 23
  5. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. (PMID: 15703209) Soulet F. … Schmid S.L. (Mol. Biol. Cell 2005) 3 4 23

Products for SNX9 Gene

Sources for SNX9 Gene

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