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Aliases for SNX8 Gene

Aliases for SNX8 Gene

  • Sorting Nexin 8 2 3
  • Sorting Nexin-8 3
  • Mvp1 3

External Ids for SNX8 Gene

Previous GeneCards Identifiers for SNX8 Gene

  • GC07M001939
  • GC07M002039
  • GC07M002040
  • GC07M002068
  • GC07M002261

Summaries for SNX8 Gene

GeneCards Summary for SNX8 Gene

SNX8 (Sorting Nexin 8) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding.

UniProtKB/Swiss-Prot for SNX8 Gene

  • May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX8 Gene

Genomics for SNX8 Gene

Regulatory Elements for SNX8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNX8 Gene

2,251,770 bp from pter
2,354,318 bp from pter
102,549 bases
Minus strand

Genomic View for SNX8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX8 Gene

Proteins for SNX8 Gene

  • Protein details for SNX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-8
    Protein Accession:
    Secondary Accessions:
    • A4D207
    • Q96I67

    Protein attributes for SNX8 Gene

    465 amino acids
    Molecular mass:
    52569 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNX8 Gene

Proteomics data for SNX8 Gene at MOPED

Post-translational modifications for SNX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX8 Gene

No data available for DME Specific Peptides for SNX8 Gene

Domains for SNX8 Gene

Gene Families for SNX8 Gene

  • SNX :Sorting nexins

Protein Domains for SNX8 Gene


Suggested Antigen Peptide Sequences for SNX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y5X2
  • Contains 1 PX (phox homology) domain.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX8: view

Function for SNX8 Gene

Molecular function for SNX8 Gene

UniProtKB/Swiss-Prot Function: May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.

Gene Ontology (GO) - Molecular Function for SNX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0035091 phosphatidylinositol binding IMP 19782049
GO:0042802 identical protein binding IPI 23085988
genes like me logo Genes that share ontologies with SNX8: view

Animal Model Products

CRISPR Products

miRNA for SNX8 Gene

miRTarBase miRNAs that target SNX8

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNX8 Gene

Localization for SNX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX8 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with retromer components.

Subcellular locations from

Jensen Localization Image for SNX8 Gene COMPARTMENTS Subcellular localization image for SNX8 gene
Compartment Confidence
endosome 5
cytosol 3
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SNX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019898 extrinsic component of membrane IBA --
GO:0030904 colocalizes_with retromer complex IDA 19782049
GO:0031901 early endosome membrane IDA 19782049
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SNX8: view

Pathways for SNX8 Gene

SuperPathways for SNX8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IMP 19782049
GO:0006897 endocytosis IBA --
GO:0016050 vesicle organization IBA --
GO:0034498 early endosome to Golgi transport IMP 19782049
genes like me logo Genes that share ontologies with SNX8: view

No data available for Pathways by source for SNX8 Gene

Transcripts for SNX8 Gene

Unigene Clusters for SNX8 Gene

Sorting nexin 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX8 Gene

No ASD Table

Relevant External Links for SNX8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX8 Gene

mRNA expression in normal human tissues for SNX8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX8 Gene

SOURCE GeneReport for Unigene cluster for SNX8 Gene Hs.584900

genes like me logo Genes that share expressions with SNX8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX8 Gene

Orthologs for SNX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNX8 35
  • 99 (n)
  • 99.35 (a)
SNX8 36
  • 99 (a)
(Bos Taurus)
Mammalia SNX8 35
  • 85.19 (n)
  • 86.49 (a)
SNX8 36
  • 86 (a)
(Canis familiaris)
Mammalia SNX8 35
  • 86.09 (n)
  • 89.28 (a)
SNX8 36
  • 88 (a)
(Mus musculus)
Mammalia Snx8 35
  • 85.62 (n)
  • 89.54 (a)
Snx8 16
Snx8 36
  • 89 (a)
(Monodelphis domestica)
Mammalia SNX8 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia SNX8 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Snx8 35
  • 85.84 (n)
  • 89.32 (a)
(Gallus gallus)
Aves SNX8 35
  • 77.36 (n)
  • 85.71 (a)
SNX8 36
  • 82 (a)
(Anolis carolinensis)
Reptilia SNX8 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx8 35
  • 71.37 (n)
  • 79.56 (a)
(Danio rerio)
Actinopterygii -- 35
snx8a 35
  • 67.2 (n)
  • 66.05 (a)
snx8a 36
  • 53 (a)
snx8b 36
  • 52 (a)
snx8b 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012012 35
  • 44.81 (n)
  • 32.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MVP1 36
  • 18 (a)
MVP1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8073 36
  • 43 (a)
Species with no ortholog for SNX8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX8 Gene

Gene Tree for SNX8 (if available)
Gene Tree for SNX8 (if available)

Paralogs for SNX8 Gene

No data available for Paralogs for SNX8 Gene

Variants for SNX8 Gene

Sequence variations from dbSNP and Humsavar for SNX8 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs878534 -- 2,275,017(+) GCCCC(A/G)GTCTA intron-variant
rs1801077 -- 2,255,121(+) TCCCG(C/G)AAAGA missense, reference
rs2256545 -- 2,252,308(+) GGGGG(A/G)AACCC utr-variant-3-prime
rs2270052 -- 2,251,764(+) TACAC(A/G)TTTAA downstream-variant-500B
rs2286205 -- 2,264,556(-) TGCTG(G/T)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX8 Gene

Variant ID Type Subtype PubMed ID
dgv7110n71 CNV Loss 21882294
nsv830886 CNV Loss 17160897
nsv887274 CNV Loss 21882294
nsv887277 CNV Loss 21882294
nsv887278 CNV Loss 21882294
nsv887279 CNV Loss 21882294
nsv887280 CNV Loss 21882294
esv1000840 CNV Deletion 20482838
nsv823980 CNV Gain 20364138

Relevant External Links for SNX8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX8 Gene

Disorders for SNX8 Gene

(1) University of Copenhagen DISEASES for SNX8 Gene

genes like me logo Genes that share disorders with SNX8: view

No data available for UniProtKB/Swiss-Prot for SNX8 Gene

Publications for SNX8 Gene

  1. Sorting nexin 8 regulates endosome-to-Golgi transport. (PMID: 19782049) Dyve A.B. … Sandvig K. (Biochem. Biophys. Res. Commun. 2009) 3 4 23
  2. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale R.D. … Gleeson P.A. (Biochem. J. 2001) 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3

Products for SNX8 Gene

Sources for SNX8 Gene

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