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Aliases for SNX8 Gene

Aliases for SNX8 Gene

  • Sorting Nexin 8 2 3 5
  • Sorting Nexin-8 3
  • Mvp1 3

External Ids for SNX8 Gene

Previous GeneCards Identifiers for SNX8 Gene

  • GC07M001939
  • GC07M002039
  • GC07M002040
  • GC07M002068
  • GC07M002261

Summaries for SNX8 Gene

GeneCards Summary for SNX8 Gene

SNX8 (Sorting Nexin 8) is a Protein Coding gene. Diseases associated with SNX8 include Tetralogy Of Fallot. GO annotations related to this gene include identical protein binding and phosphatidylinositol binding.

UniProtKB/Swiss-Prot for SNX8 Gene

  • May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.

Additional gene information for SNX8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX8 Gene

Genomics for SNX8 Gene

Regulatory Elements for SNX8 Gene

Enhancers for SNX8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H002309 1.4 FANTOM5 ENCODE 22 +42.0 42040 5.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 ZBTB7B SNX8 MRM2 NUDT1 MAD1L1 CHST12 BRAT1 GC07P002305 GC07M002345
GH07H002298 1.5 FANTOM5 Ensembl ENCODE 13.8 +54.1 54100 3.8 HDGF PKNOX1 TBL1XR1 SIN3A NFXL1 BMI1 BATF TCF12 EGR1 ATF7 MRM2 SNX8 NUDT1 MAD1L1 LFNG GC07P002305 IMMP1LP3
GH07H002306 1.1 Ensembl ENCODE 14.6 +46.6 46623 2.1 HDAC1 HDGF PKNOX1 BMI1 RELA ZFHX2 POLR2A EED ZNF143 ATF7 SNX8 MRM2 NUDT1 MAD1L1 GC07P002305 GC07M002345
GH07H002325 0.9 FANTOM5 Ensembl 17.3 +28.9 28941 0.4 HDAC1 SMARCE1 CTBP1 SMARCA4 IKZF1 SNX8 EIF3B MRM2 NUDT1 MAD1L1 LOC645357 CHST12 LFNG GC07P002305 GC07M002345
GH07H002451 1.2 Ensembl ENCODE 11.8 -97.7 -97746 1.8 HDGF RB1 ARID4B SIN3A DMAP1 ZNF2 RAD21 SLC30A9 GLIS2 ZNF143 CHST12 BRAT1 IQCE LOC645357 EIF3B SNX8 TTYH3 AMZ1 LFNG GRIFIN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNX8 on UCSC Golden Path with GeneCards custom track

Promoters for SNX8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000207760 -482 2801 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766

Genomic Locations for SNX8 Gene

Genomic Locations for SNX8 Gene
102,549 bases
Minus strand

Genomic View for SNX8 Gene

Genes around SNX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX8 Gene

Proteins for SNX8 Gene

  • Protein details for SNX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-8
    Protein Accession:
    Secondary Accessions:
    • A4D207
    • Q96I67

    Protein attributes for SNX8 Gene

    465 amino acids
    Molecular mass:
    52569 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNX8 Gene

Post-translational modifications for SNX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX8 Gene

Domains & Families for SNX8 Gene

Gene Families for SNX8 Gene

Protein Domains for SNX8 Gene


Suggested Antigen Peptide Sequences for SNX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sorting nexin family.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX8: view

Function for SNX8 Gene

Molecular function for SNX8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.

Phenotypes From GWAS Catalog for SNX8 Gene

Gene Ontology (GO) - Molecular Function for SNX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008289 lipid binding IEA --
GO:0035091 phosphatidylinositol binding IMP,IEA 19782049
GO:0042802 identical protein binding IPI 23085988
genes like me logo Genes that share ontologies with SNX8: view
genes like me logo Genes that share phenotypes with SNX8: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX8 Gene

Localization for SNX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX8 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with retromer components.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX8 gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IBA --
GO:0030904 colocalizes_with retromer complex IDA 19782049
genes like me logo Genes that share ontologies with SNX8: view

Pathways & Interactions for SNX8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IMP 19782049
GO:0006897 endocytosis IBA --
GO:0015031 protein transport IEA --
GO:0016050 vesicle organization IBA --
genes like me logo Genes that share ontologies with SNX8: view

No data available for Pathways by source and SIGNOR curated interactions for SNX8 Gene

Drugs & Compounds for SNX8 Gene

No Compound Related Data Available

Transcripts for SNX8 Gene

Unigene Clusters for SNX8 Gene

Sorting nexin 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX8 Gene

No ASD Table

Relevant External Links for SNX8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX8 Gene

Protein differential expression in normal tissues from HIPED for SNX8 Gene

This gene is overexpressed in Adrenal (13.8), Testis (11.0), Plasma (8.9), and Spleen (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX8 Gene

Protein tissue co-expression partners for SNX8 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNX8 Gene:


SOURCE GeneReport for Unigene cluster for SNX8 Gene:


Evidence on tissue expression from TISSUES for SNX8 Gene

  • Kidney(4.4)
  • Lung(4.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with SNX8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX8 Gene

Orthologs for SNX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNX8 33 34
  • 99 (n)
(Monodelphis domestica)
Mammalia SNX8 34
  • 91 (a)
(Canis familiaris)
Mammalia SNX8 33 34
  • 86.09 (n)
(Rattus norvegicus)
Mammalia Snx8 33
  • 85.84 (n)
(Mus musculus)
Mammalia Snx8 33 16 34
  • 85.62 (n)
(Bos Taurus)
Mammalia SNX8 33 34
  • 85.19 (n)
(Ornithorhynchus anatinus)
Mammalia SNX8 34
  • 85 (a)
(Gallus gallus)
Aves SNX8 33 34
  • 77.36 (n)
(Anolis carolinensis)
Reptilia SNX8 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx8 33
  • 71.37 (n)
(Danio rerio)
Actinopterygii snx8a 33 34
  • 67.2 (n)
snx8b 34 34
  • 52 (a)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012012 33
  • 44.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MVP1 34 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8073 34
  • 43 (a)
Species where no ortholog for SNX8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX8 Gene

Gene Tree for SNX8 (if available)
Gene Tree for SNX8 (if available)

Paralogs for SNX8 Gene

No data available for Paralogs for SNX8 Gene

Variants for SNX8 Gene

Sequence variations from dbSNP and Humsavar for SNX8 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036259 A colorectal cancer sample
rs1000000608 -- 2,261,182(+) AATCC(C/T)AGCAC intron-variant
rs1000025529 -- 2,303,111(+) GGGGG(A/G)GTCAG intron-variant
rs1000026037 -- 2,317,303(+) AGACA(C/G)AGTCT intron-variant
rs1000043891 -- 2,334,328(+) AACCC(A/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX8 Gene

Variant ID Type Subtype PubMed ID
nsv830886 CNV loss 17160897
nsv823980 CNV gain 20364138
nsv1021310 CNV loss 25217958
nsv1021173 CNV loss 25217958
nsv1018563 CNV gain 25217958
esv3611836 CNV loss 21293372
esv2761136 CNV gain 21179565
esv1000840 CNV deletion 20482838
dgv3475n106 CNV duplication 24896259

Variation tolerance for SNX8 Gene

Residual Variation Intolerance Score: 8.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX8 Gene

Disorders for SNX8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNX8 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
tetralogy of fallot
  • ventricular septal defect with pulmonary stenosis or atresia, dextraposition of aorta, and hypertrophy of right ventricle
- elite association - COSMIC cancer census association via MalaCards
Search SNX8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SNX8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SNX8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNX8 Gene

Publications for SNX8 Gene

  1. Sorting nexin 8 regulates endosome-to-Golgi transport. (PMID: 19782049) Dyve AB … Sandvig K (Biochemical and biophysical research communications 2009) 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  4. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale RD … Gleeson PA (The Biochemical journal 2001) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SNX8 Gene

Sources for SNX8 Gene

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