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Aliases for SNX8 Gene

Aliases for SNX8 Gene

  • Sorting Nexin 8 2 3 5
  • Sorting Nexin-8 3
  • Mvp1 3

External Ids for SNX8 Gene

Previous GeneCards Identifiers for SNX8 Gene

  • GC07M001939
  • GC07M002039
  • GC07M002040
  • GC07M002068
  • GC07M002261

Summaries for SNX8 Gene

GeneCards Summary for SNX8 Gene

SNX8 (Sorting Nexin 8) is a Protein Coding gene. Diseases associated with SNX8 include Tetralogy Of Fallot and Hand, Foot And Mouth Disease. GO annotations related to this gene include identical protein binding and phosphatidylinositol binding.

UniProtKB/Swiss-Prot for SNX8 Gene

  • May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX8 Gene

Genomics for SNX8 Gene

Regulatory Elements for SNX8 Gene

Enhancers for SNX8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G002309 1.5 FANTOM5 ENCODE 22 +42.0 42040 5.7 CREB3L1 MLX YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SNX8 MRM2 NUDT1 MAD1L1 GC07P002305 GC07M002345
GH07G002298 1.5 FANTOM5 Ensembl ENCODE 13.8 +54.1 54100 3.8 HDGF PKNOX1 CREB3L1 SIN3A TCF12 FOS JUNB TBX21 SMARCA4 PBX2 MRM2 SNX8 NUDT1 MAD1L1 LFNG GC07P002305 IMMP1LP3
GH07G002325 1 FANTOM5 Ensembl 17.3 +28.9 28941 0.4 HDAC1 SMARCE1 CTCF STAT1 RAD21 ARID1B SMARCA4 IKZF1 SMC3 ZBTB33 SNX8 EIF3B NUDT1 MRM2 MAD1L1 LOC645357 CHST12 LFNG GC07P002305 GC07M002345
GH07G002306 1.1 Ensembl ENCODE 14.6 +46.6 46623 2.1 HDAC1 HDGF PKNOX1 RB1 ARID4B BMI1 RAD21 EGR1 ZNF143 RELB SNX8 MRM2 NUDT1 MAD1L1 GC07P002305 GC07M002345
GH07G002451 1.2 Ensembl ENCODE 11.8 -97.7 -97746 1.8 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZNF48 CHST12 BRAT1 IQCE LOC645357 EIF3B SNX8 TTYH3 AMZ1 LFNG GRIFIN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNX8 on UCSC Golden Path with GeneCards custom track

Promoters for SNX8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000207757 275 1601 CREB3L1 MLX YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for SNX8 Gene

Chromosome:
7
Start:
2,251,770 bp from pter
End:
2,354,318 bp from pter
Size:
102,549 bases
Orientation:
Minus strand

Genomic View for SNX8 Gene

Genes around SNX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX8 Gene

Proteins for SNX8 Gene

  • Protein details for SNX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5X2-SNX8_HUMAN
    Recommended name:
    Sorting nexin-8
    Protein Accession:
    Q9Y5X2
    Secondary Accessions:
    • A4D207
    • Q96I67

    Protein attributes for SNX8 Gene

    Size:
    465 amino acids
    Molecular mass:
    52569 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNX8 Gene

Post-translational modifications for SNX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX8 Gene

Domains & Families for SNX8 Gene

Gene Families for SNX8 Gene

Protein Domains for SNX8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5X2

UniProtKB/Swiss-Prot:

SNX8_HUMAN :
  • Belongs to the sorting nexin family.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX8: view

Function for SNX8 Gene

Molecular function for SNX8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.

Gene Ontology (GO) - Molecular Function for SNX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008289 lipid binding IEA --
GO:0035091 phosphatidylinositol binding IMP,IEA 19782049
GO:0042802 identical protein binding IPI 23085988
genes like me logo Genes that share ontologies with SNX8: view
genes like me logo Genes that share phenotypes with SNX8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX8 Gene

Localization for SNX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX8 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with retromer components.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX8 gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SNX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IBA --
GO:0030904 colocalizes_with retromer complex IDA 19782049
genes like me logo Genes that share ontologies with SNX8: view

Pathways & Interactions for SNX8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IMP 19782049
GO:0006897 endocytosis IBA --
GO:0015031 protein transport IEA --
GO:0016050 vesicle organization IBA --
genes like me logo Genes that share ontologies with SNX8: view

No data available for Pathways by source and SIGNOR curated interactions for SNX8 Gene

Transcripts for SNX8 Gene

Unigene Clusters for SNX8 Gene

Sorting nexin 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX8 Gene

No ASD Table

Relevant External Links for SNX8 Gene

GeneLoc Exon Structure for
SNX8
ECgene alternative splicing isoforms for
SNX8

Expression for SNX8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX8 Gene

Protein differential expression in normal tissues from HIPED for SNX8 Gene

This gene is overexpressed in Adrenal (13.8), Testis (11.0), Plasma (8.9), and Spleen (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX8 Gene



Protein tissue co-expression partners for SNX8 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNX8 Gene:

SNX8

SOURCE GeneReport for Unigene cluster for SNX8 Gene:

Hs.584900

Evidence on tissue expression from TISSUES for SNX8 Gene

  • Kidney(4.4)
  • Lung(4.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with SNX8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX8 Gene

Orthologs for SNX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX8 34 35
  • 99 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX8 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX8 34 35
  • 86.09 (n)
rat
(Rattus norvegicus)
Mammalia Snx8 34
  • 85.84 (n)
mouse
(Mus musculus)
Mammalia Snx8 35 16 34
  • 85.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SNX8 34 35
  • 85.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SNX8 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX8 35 34
  • 77.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX8 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx8 34
  • 71.37 (n)
zebrafish
(Danio rerio)
Actinopterygii snx8a 34 35
  • 67.2 (n)
snx8b 35 35
  • 52 (a)
OneToMany
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012012 34
  • 44.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MVP1 35 37
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8073 35
  • 43 (a)
OneToOne
Species where no ortholog for SNX8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX8 Gene

ENSEMBL:
Gene Tree for SNX8 (if available)
TreeFam:
Gene Tree for SNX8 (if available)

Paralogs for SNX8 Gene

No data available for Paralogs for SNX8 Gene

Variants for SNX8 Gene

Sequence variations from dbSNP and Humsavar for SNX8 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036259 A colorectal cancer sample
rs1000000608 -- 2,261,182(+) AATCC(C/T)AGCAC intron-variant
rs1000025529 -- 2,303,111(+) GGGGG(A/G)GTCAG intron-variant
rs1000026037 -- 2,317,303(+) AGACA(C/G)AGTCT intron-variant
rs1000043891 -- 2,334,328(+) AACCC(A/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX8 Gene

Variant ID Type Subtype PubMed ID
dgv3475n106 CNV duplication 24896259
esv1000840 CNV deletion 20482838
esv2761136 CNV gain 21179565
esv3611836 CNV loss 21293372
nsv1018563 CNV gain 25217958
nsv1021173 CNV loss 25217958
nsv1021310 CNV loss 25217958
nsv823980 CNV gain 20364138
nsv830886 CNV loss 17160897

Variation tolerance for SNX8 Gene

Residual Variation Intolerance Score: 8.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX8 Gene

Human Gene Mutation Database (HGMD)
SNX8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX8 Gene

Disorders for SNX8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SNX8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tetralogy of fallot
  • tetrology of fallot
hand, foot and mouth disease
  • vesicular stomatitis and exanthem
- elite association - COSMIC cancer census association via MalaCards
Search SNX8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SNX8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX8
genes like me logo Genes that share disorders with SNX8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNX8 Gene

Publications for SNX8 Gene

  1. Sorting nexin 8 regulates endosome-to-Golgi transport. (PMID: 19782049) Dyve A.B. … Sandvig K. (Biochem. Biophys. Res. Commun. 2009) 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale R.D. … Gleeson P.A. (Biochem. J. 2001) 3 4 64
  5. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3 64

Products for SNX8 Gene

Sources for SNX8 Gene

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