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Aliases for SNX8 Gene

Aliases for SNX8 Gene

  • Sorting Nexin 8 2 3 5
  • Mvp1 3

External Ids for SNX8 Gene

Previous GeneCards Identifiers for SNX8 Gene

  • GC07M001939
  • GC07M002039
  • GC07M002040
  • GC07M002068
  • GC07M002261

Summaries for SNX8 Gene

GeneCards Summary for SNX8 Gene

SNX8 (Sorting Nexin 8) is a Protein Coding gene. Diseases associated with SNX8 include Tetralogy Of Fallot. GO annotations related to this gene include identical protein binding and phosphatidylinositol binding.

UniProtKB/Swiss-Prot for SNX8 Gene

  • May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX8 Gene

Genomics for SNX8 Gene

Regulatory Elements for SNX8 Gene

Enhancers for SNX8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNX8 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX8 Gene

Chromosome:
7
Start:
2,251,770 bp from pter
End:
2,354,318 bp from pter
Size:
102,549 bases
Orientation:
Minus strand

Genomic View for SNX8 Gene

Genes around SNX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX8 Gene

Proteins for SNX8 Gene

  • Protein details for SNX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5X2-SNX8_HUMAN
    Recommended name:
    Sorting nexin-8
    Protein Accession:
    Q9Y5X2
    Secondary Accessions:
    • A4D207
    • Q96I67

    Protein attributes for SNX8 Gene

    Size:
    465 amino acids
    Molecular mass:
    52569 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNX8 Gene

Proteomics data for SNX8 Gene at MOPED

Post-translational modifications for SNX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX8 Gene

No data available for DME Specific Peptides for SNX8 Gene

Domains & Families for SNX8 Gene

Gene Families for SNX8 Gene

Protein Domains for SNX8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5X2

UniProtKB/Swiss-Prot:

SNX8_HUMAN :
  • Contains 1 PX (phox homology) domain.
  • Belongs to the sorting nexin family.
Domain:
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX8: view

Function for SNX8 Gene

Molecular function for SNX8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.
genes like me logo Genes that share phenotypes with SNX8: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX8 Gene

Localization for SNX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX8 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with retromer components.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX8 Gene COMPARTMENTS Subcellular localization image for SNX8 gene
Compartment Confidence
endosome 5
cytosol 3
nucleus 2
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SNX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IMP 19782049
GO:0031901 early endosome membrane IDA 19782049
genes like me logo Genes that share ontologies with SNX8: view

Pathways & Interactions for SNX8 Gene

SuperPathways for SNX8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IMP 19782049
GO:0006897 endocytosis IBA --
GO:0016050 vesicle organization IBA --
genes like me logo Genes that share ontologies with SNX8: view

No data available for Pathways by source and SIGNOR curated interactions for SNX8 Gene

Drugs & Compounds for SNX8 Gene

No Compound Related Data Available

Transcripts for SNX8 Gene

Unigene Clusters for SNX8 Gene

Sorting nexin 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX8 Gene

No ASD Table

Relevant External Links for SNX8 Gene

GeneLoc Exon Structure for
SNX8
ECgene alternative splicing isoforms for
SNX8

Expression for SNX8 Gene

mRNA expression in normal human tissues for SNX8 Gene

Protein differential expression in normal tissues from HIPED for SNX8 Gene

This gene is overexpressed in Adrenal (13.8), Testis (11.0), Plasma (8.9), and Spleen (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX8 Gene



SOURCE GeneReport for Unigene cluster for SNX8 Gene Hs.584900

genes like me logo Genes that share expression patterns with SNX8: view

Protein tissue co-expression partners for SNX8 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX8 Gene

Orthologs for SNX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNX8 35
  • 85.19 (n)
  • 86.49 (a)
SNX8 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX8 35
  • 86.09 (n)
  • 89.28 (a)
SNX8 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx8 35
  • 85.62 (n)
  • 89.54 (a)
Snx8 16
Snx8 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNX8 35
  • 99 (n)
  • 99.35 (a)
SNX8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx8 35
  • 85.84 (n)
  • 89.32 (a)
oppossum
(Monodelphis domestica)
Mammalia SNX8 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX8 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX8 35
  • 77.36 (n)
  • 85.71 (a)
SNX8 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX8 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx8 35
  • 71.37 (n)
  • 79.56 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
snx8a 35
  • 67.2 (n)
  • 66.05 (a)
snx8a 36
  • 53 (a)
OneToMany
snx8b 36
  • 52 (a)
OneToMany
snx8b 36
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012012 35
  • 44.81 (n)
  • 32.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MVP1 36
  • 18 (a)
OneToOne
MVP1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8073 36
  • 43 (a)
OneToOne
Species with no ortholog for SNX8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX8 Gene

ENSEMBL:
Gene Tree for SNX8 (if available)
TreeFam:
Gene Tree for SNX8 (if available)

Paralogs for SNX8 Gene

No data available for Paralogs for SNX8 Gene

Variants for SNX8 Gene

Sequence variations from dbSNP and Humsavar for SNX8 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036259 A colorectal cancer sample
rs878534 -- 2,275,017(+) GCCCC(A/G)GTCTA intron-variant
rs6947645 -- 2,269,720(+) GGAGC(A/G)GGAGG intron-variant
rs6949625 -- 2,308,229(+) TATTC(C/T)AGATA intron-variant
rs6952224 -- 2,303,986(+) aaaaa(A/T)taaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX8 Gene

Variant ID Type Subtype PubMed ID
dgv7110n71 CNV Loss 21882294
nsv830886 CNV Loss 17160897
nsv887274 CNV Loss 21882294
nsv887277 CNV Loss 21882294
nsv887278 CNV Loss 21882294
nsv887279 CNV Loss 21882294
nsv887280 CNV Loss 21882294
esv1000840 CNV Deletion 20482838
nsv823980 CNV Gain 20364138

Variation tolerance for SNX8 Gene

Residual Variation Intolerance Score: 8.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX8 Gene

Human Gene Mutation Database (HGMD)
SNX8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX8 Gene

Disorders for SNX8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNX8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tetralogy of fallot
  • tetrology of fallot
- elite association - COSMIC cancer census association via MalaCards
Search SNX8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SNX8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX8
genes like me logo Genes that share disorders with SNX8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNX8 Gene

Publications for SNX8 Gene

  1. Sorting nexin 8 regulates endosome-to-Golgi transport. (PMID: 19782049) Dyve A.B. … Sandvig K. (Biochem. Biophys. Res. Commun. 2009) 3 4 23 67
  2. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. SNX8: A candidate gene for 7p22 cardiac malformations including tetralogy of fallot. (PMID: 24311514) Vanzo R.J. … South S.T. (Am. J. Med. Genet. A 2014) 3
  5. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3

Products for SNX8 Gene

Sources for SNX8 Gene

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