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SNX8 Gene

protein-coding   GIFtS: 52
GCID: GC07M002261

Sorting Nexin 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sorting Nexin 81 2
Mvp12
Sorting Nexin-82

External Ids:    HGNC: 149721   Entrez Gene: 298862   Ensembl: ENSG000001062667   OMIM: 6149055   UniProtKB: Q9Y5X23   

Export aliases for SNX8 gene to outside databases

Previous GC identifers: GC07M001939 GC07M002039 GC07M002040 GC07M002068


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SNX8 Gene:
SNX8 (sorting nexin 8) is a protein-coding gene. Diseases associated with SNX8 include tetralogy of fallot, and breast and colorectal cancer. GO annotations related to this gene include phosphatidylinositol binding.

UniProtKB/Swiss-Prot: SNX8_HUMAN, Q9Y5X2
Function: May be involved in several stages of intracellular trafficking. May play a role in intracellular protein
transport from early endosomes to the trans-Golgi network




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNX8 gene promoter:
         STAT1   STAT1beta   STAT1alpha   Egr-4   CREB   Pax-3   deltaCREB   Meis-1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): SNX8 promoter sequence
   Search Chromatin IP Primers for SNX8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNX8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

SNX8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX8 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M002261:  view genomic region     (about GC identifiers)

Start:
2,291,405 bp from pter      End:
2,393,953 bp from pter
Size:
102,549 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 2,340,080-2,402,509     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SNX8_HUMAN, Q9Y5X2 (See protein sequence)
Recommended Name: Sorting nexin-8  
Size: 465 amino acids; 52569 Da
Secondary accessions: A4D207 Q96I67

Explore the universe of human proteins at neXtProt for SNX8: NX_Q9Y5X2

Explore proteomics data for SNX8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SNX8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037453.1  
    ENSEMBL proteins: 
     ENSP00000222990   ENSP00000392437   ENSP00000406954   ENSP00000406212   ENSP00000403608  
     ENSP00000399127  

    SNX8 Human Recombinant Protein Products:

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    Novus Biologicals SNX8 Proteins
    Novus Biologicals SNX8 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SNX8

    SNX8 Antibody Products:

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    Abcam antibodies for SNX8
    Cloud-Clone Corp. Antibodies for SNX8
    Search ThermoFisher Antibodies for SNX8
    LSBio Antibodies in human, mouse, rat for SNX8

    SNX8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SNX8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNX8
    Cloud-Clone Corp. CLIAs for SNX8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SNX: Sorting nexins

    2 InterPro protein domains:
     IPR028662 SNX8
     IPR001683 Phox

    Graphical View of Domain Structure for InterPro Entry Q9Y5X2

    ProtoNet protein and cluster: Q9Y5X2

    1 Blocks protein domain: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SNX8_HUMAN, Q9Y5X2
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain


    SNX8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNX8_HUMAN, Q9Y5X2
    Function: May be involved in several stages of intracellular trafficking. May play a role in intracellular protein
    transport from early endosomes to the trans-Golgi network

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17474147
    GO:0035091phosphatidylinositol binding IMP19782049
    GO:0042802identical protein binding IPI--
         
    SNX8 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNX8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNX8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNX8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNX8

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNX8:
    hsa-mir-107 (MIRT048293), hsa-mir-423-5p (MIRT038133)

    Block miRNA regulation of human, mouse, rat SNX8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX8 (see all 30):
    hsa-miR-30c hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-30d hsa-miR-302e hsa-miR-583
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SNX8
    Predesigned siRNA for gene silencing in human, mouse, rat SNX8

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SNX8 (NM_013321)
    Sino Biological Human cDNA Clone for SNX8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX8

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNX8_HUMAN, Q9Y5X2: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes
    with retromer components
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030904colocalizes with retromer complex IDA19782049
    GO:0031901early endosome membrane IDA19782049

    SNX8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNX8
    Interactions:

        Search GeneGlobe Interaction Network for SNX8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNX8 (Q9Y5X21, 2, 3 ENSP000002229904) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163331, 3, ENSP000002889864EBI-1752557,EBI-389883 I2D: score=1 STRING: ENSP00000288986
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IMP19782049
    GO:0007154cell communication ----
    GO:0034498early endosome to Golgi transport IMP19782049

    SNX8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNX8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SNX8 gene: 
    NM_013321.2  

    Unigene Cluster for SNX8:

    Sorting nexin 8
    Hs.584900  [show with all ESTs]
    Unigene Representative Sequence: NM_013321
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222990(uc003slw.3) ENST00000480807 ENST00000479689 ENST00000435060
    ENST00000457286 ENST00000435336 ENST00000494722 ENST00000447136 ENST00000419693

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNX8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX8 (see all 30):
    hsa-miR-30c hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-30d hsa-miR-302e hsa-miR-583
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNX8
    Predesigned siRNA for gene silencing in human, mouse, rat SNX8
    Clone
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    OriGene clones in human, mouse for SNX8 (see all 6)
    OriGene ORF clones in mouse, rat for SNX8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNX8 (NM_013321)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNX8
    OriGene qSTAR qPCR primer pairs in human, mouse for SNX8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNX8
      QuantiTect SYBR Green Assays in human, mouse, rat SNX8
      QuantiFast Probe-based Assays in human, mouse, rat SNX8

    Additional mRNA sequence: 

    AF121858.1 AK074544.1 AK315670.1 AL713633.1 BC007785.2 BC014395.1 BC021565.1 

    9 DOTS entries:

    DT.444568  DT.100779975  DT.40200625  DT.100779974  DT.121124385  DT.91797117  DT.95072563  DT.95360001 
    DT.75126385 

    Selected AceView cDNA sequences (see all 208):

    BU527816 BG761296 BG425549 AI122675 CB132058 BI833128 BM846608 BU521269 
    AW249686 BP432798 CF242839 BQ897850 CB140898 BX104001 CB124021 BI762303 
    BQ053737 CD675413 AI126793 BE464306 BM811303 BQ057267 BQ222866 AI655247 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNX8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGGGCGT
    SNX8 Expression
    About this image

    SNX8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNX8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584900
        Custom PCR Arrays for SNX8
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SNX8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SNX8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snx81 , 5 sorting nexin 81, 5 85.62(n)1
    89.54(a)1
      5 (78.95 cM)5
    2318341  NM_172277.21  NP_758481.11 
     1403403035 
    chicken
    (Gallus gallus)
    Aves SNX81 sorting nexin 8 77.36(n)
    85.71(a)
      416468  XM_004945138.1  XP_004945195.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNX86
    sorting nexin 8
    84(a)
    1 ↔ 1
    GL343340.1(12381-26345)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia snx81 sorting nexin 8 71.37(n)
    79.56(a)
      100495787  XM_002944822.2  XP_002944868.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CF924902.12   -- 72.99(n)   387289  CF924902.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0120121 AgaP_AGAP012012 44.81(n)
    32.63(a)
      1280658  XM_320519.4  XP_320519.4 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MVP1(YMR004W)4 Protein required for sorting proteins to the vacuole; more   --   13(274017-275552) 855016  NP_013717.1 


    ENSEMBL Gene Tree for SNX8 (if available)
    TreeFam Gene Tree for SNX8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNX8 (see all 1708)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362594
    A colorectal cancer sample4--see VAR_0362592 A G mis40--------
    rs1929156011,2
    --2291336(+) GCTCTA/GGGCTA 1 -- int10--------
    rs22700521,2
    C,F,A,H--2291399(+) TACACG/ATTTAA 1 -- int121Minor allele frequency- A:0.39EA NS NA CSA WA 3513
    rs1385659461,2
    --2291454(+) AGGTCA/CTGTGT 1 -- ut310--------
    rs765062041,2
    --2291558(+) GCCTCA/CGATGC 1 -- ut310--------
    rs1142761171,2
    C,F--2291678(+) GCACGG/ATGACC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs785185741,2
    F--2291701(+) GACACG/AGACCA 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs715503361,2
    C,F--2291779(+) CACAACCCCCCTC
    CCACGG
    /-
    CCCCG
    2 -- ut312Minor allele frequency- -:0.50NA CSA 4
    rs1489285501,2
    C--2291779(+) CACAA-/CCCCCC
    TCCCACGG
    GCCCC
    1 -- ut310--------
    rs2016573061,2
    C--2291792(-) CGGGGC/TCGTGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SNX8 (2291405 - 2393953 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SNX8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1000840CNV Deletion20482838
    nsv887278CNV Loss21882294
    nsv887277CNV Loss21882294
    nsv830886CNV Loss17160897
    nsv887280CNV Loss21882294
    nsv887274CNV Loss21882294
    dgv7110n71CNV Loss21882294
    nsv887279CNV Loss21882294
    nsv823980CNV Gain20364138

    Human Gene Mutation Database (HGMD): SNX8
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SNX8
    DNA2.0 Custom Variant and Variant Library Synthesis for SNX8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614905    OMIM disorders: --

    6 diseases for SNX8:    
    About MalaCards
    tetralogy of fallot    breast and colorectal cancer    bipolar disorder    schizophrenia
    colorectal cancer    malaria

    1 disease from the University of Copenhagen DISEASES database for SNX8:
    Tetralogy of Fallot

    SNX8 for disorders           About GeneDecksing


    Export disorders for SNX8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNX8 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SNX8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sorting nexin 8 regulates endosome-to-Golgi transport. (PubMed id 19782049)1, 2, 9 Dyve A.B.... Sandvig K. (Biochem. Biophys. Res. Commun. 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)1, 2 Teasdale R.D.... Gleeson P.A. (Biochem. J. 2001)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation. (PubMed id 21973056)1 van Weering J.R....Cullen P.J. (Traffic 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (Mol. Psychiatry 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29886 HGNC: 14972 AceView: SNX8 Ensembl:ENSG00000106266 euGenes: HUgn29886
    ECgene: SNX8 H-InvDB: SNX8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNX8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNX8 gene:
    Search GeneIP for patents involving SNX8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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