SNX8 Gene
protein-coding GIFtS: 48
GCID: GC07M002261
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|
sorting nexin 8
| |
Aliases
for SNX8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sorting Nexin 81 2 | | Mvp11 2 | | Sorting Nexin-82 |
Export aliases for SNX8 gene to outside databasesPrevious GC identifers: GC07M001939 GC07M002039 GC07M002040 GC07M002068 |
Summaries
for SNX8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SNX8_HUMAN, Q9Y5X2Function: May be involved in several stages of intracellular trafficking. May play a role in intracellular proteintransport from early endosomes to the trans-Golgi network
|
Genomic Views
for SNX8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNX8 gene promoter:
STAT1 STAT1beta STAT1alpha Egr-4 CREB Pax-3 deltaCREB Meis-1a ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22.3SNX8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M002261: view genomic region
(about GC identifiers)
Start:
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2,291,405 bp from pter |
End:
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2,393,953 bp from pter |
Size:
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102,549 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 2,343,312-2,402,509 |
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Proteins
for SNX8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNX8_HUMAN, Q9Y5X2 (See
protein sequence)Recommended Name: Sorting nexin-8 Size: 465 amino acids; 52569 Da
Subcellular location: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes withretromer components
Secondary accessions: A4D207 Q96I67Explore the universe of human proteins at neXtProt for SNX8: NX_Q9Y5X2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y5X2
SNX8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037453.1
ENSEMBL proteins: ENSP00000222990 ENSP00000392437 ENSP00000406954 ENSP00000406212 ENSP00000403608 ENSP00000399127
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SNX8 for ontologies About GeneDecksing
SNX8 Antibody Products:
Assay Products for SNX8: |
Protein
Domains /
Families
for SNX8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX8 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y5X2ProtoNet protein and cluster: Q9Y5X2 1 Blocks protein family: IPB001683 Phox-like
UniProtKB/Swiss-Prot: SNX8_HUMAN, Q9Y5X2Similarity: Belongs to the sorting nexin familySimilarity: Contains 1 PX (phox homology) domain |
Function
for SNX8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNX8_HUMAN, Q9Y5X2Function: May be involved in several stages of intracellular trafficking. May play a role in intracellular proteintransport from early endosomes to the trans-Golgi network
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX8 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SNX8 for ontologies About GeneDecksing
|
Pathways & Interactions
for SNX8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for SNX8 (Q9Y5X21, 2, 3 ENSP000002229904) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SNX8 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNX8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNX8
Search CenterWatch for drugs/clinical trials and news about SNX8
|
Transcripts
for SNX8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNX8 gene: NM_013321.2 Unigene Cluster for SNX8: Sorting nexin 8 Hs.584900 [show with all ESTs]Unigene Representative Sequence: NM_0133219 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000222990(uc003slw.3) ENST00000480807 ENST00000479689 ENST00000435060
ENST00000457286 ENST00000435336 ENST00000494722 ENST00000447136 ENST00000419693
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNX8 (NM_013321) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX8 |
Additional cDNA sequence: AF121858.1 AK074544.1 AK315670.1 AL713633.1 BC007785.2 BC014395.1 BC021565.1 9 DOTS entries: DT.444568 DT.100779975 DT.40200625 DT.100779974 DT.121124385 DT.91797117 DT.95072563 DT.95360001 DT.75126385 24/208 AceView cDNA sequences (see all 208): BQ897850 CF242839 BQ053737 BX104001 BQ652527 CB140898 BI826664 CB124021 CD675413 C00868 BQ222866 BM811303 BP432798 BU527816 BI833128 BQ057267 BI762303 AI655247 BG425549 AI126793 BG761296 AI122675 AW249686 CB132058
GeneLoc Exon Structure
|
Expression
for SNX8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAGGGCGT
About this image
See SNX8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX8
SOURCE GeneReport for Unigene cluster: Hs.584900
SABiosciences Custom PCR Arrays for SNX8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX8 |
Orthologs
for SNX8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for SNX8 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for SNX8 (if available)
TreeFam Gene Tree for SNX8 (if available) |
Paralogs
for SNX8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SNX8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX8 (2291405 - 2393953 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNX8: --
Human Gene Mutation Database (HGMD): SNX8
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SNX8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNX8 for disorders About GeneDecksing
OMIM gene information: 614905
OMIM disorders: --
1  disease for SNX8: About MalaCardstetralogy of fallot
1 disease from the University of Copenhagen DISEASES database for SNX8:Tetralogy of Fallot Export disorders for SNX8 gene to outside databases
|
Publications
for SNX8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX8 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SNX8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sorting nexin 8 regulates endosome-to-Golgi transport . (PubMed id 19782049)1, 2, 9 Dyve A.B....Sandvig K. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)1, 2 Teasdale R.D.... Gleeson P.A. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- SNX-BAR-mediated endosome tubulation is co-ordinated w ith endosome maturation. (PubMed id 21973056)1 van Weering J.R....Cullen P.J. (2012)
- Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared wit h bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for SNX8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNX8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNX8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNX8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX8 gene:
Search GeneIP for patents involving SNX8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNX8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for SNX8 | | OriGene Custom Protein Services for SNX8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX8 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX8 |
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| | | | Search Tocris compounds for SNX8 |
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 | | | SNX8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX8 |
|  |  |  | | | | Search ThermoFisher Antibodies for SNX8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX8 |
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