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Aliases for SNX7 Gene

Aliases for SNX7 Gene

  • Sorting Nexin 7 2 3

External Ids for SNX7 Gene

Previous GeneCards Identifiers for SNX7 Gene

  • GC01P099924
  • GC01P098252
  • GC01P098418
  • GC01P098839
  • GC01P099127
  • GC01P097250

Summaries for SNX7 Gene

Entrez Gene Summary for SNX7 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its exact function is unknown. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jun 2010]

GeneCards Summary for SNX7 Gene

SNX7 (Sorting Nexin 7) is a Protein Coding gene. Diseases associated with SNX7 include hiatus hernia. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX4.

UniProtKB/Swiss-Prot for SNX7 Gene

  • May be involved in several stages of intracellular trafficking

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX7 Gene

Genomics for SNX7 Gene

Regulatory Elements for SNX7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNX7 Gene

Start:
98,661,662 bp from pter
End:
98,760,500 bp from pter
Size:
98,839 bases
Orientation:
Plus strand

Genomic View for SNX7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX7 Gene

Proteins for SNX7 Gene

  • Protein details for SNX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNH6-SNX7_HUMAN
    Recommended name:
    Sorting nexin-7
    Protein Accession:
    Q9UNH6
    Secondary Accessions:
    • A8KAF3
    • D3DT50
    • Q53FQ3
    • Q5VT09
    • Q5VT10
    • Q86U82
    • Q8WVD4
    • Q96FW9
    • Q9Y3Z7

    Protein attributes for SNX7 Gene

    Size:
    387 amino acids
    Molecular mass:
    45303 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD27830.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96949.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNX7 Gene

    Alternative splice isoforms for SNX7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX7 Gene

Proteomics data for SNX7 Gene at MOPED

Post-translational modifications for SNX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX7 Gene

No data available for DME Specific Peptides for SNX7 Gene

Domains for SNX7 Gene

Gene Families for SNX7 Gene

HGNC:
  • SNX :Sorting nexins

Protein Domains for SNX7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNH6

UniProtKB/Swiss-Prot:

SNX7_HUMAN :
  • Q9UNH6
Domain:
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX7: view

Function for SNX7 Gene

Molecular function for SNX7 Gene

UniProtKB/Swiss-Prot Function: May be involved in several stages of intracellular trafficking

Gene Ontology (GO) - Molecular Function for SNX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0035091 phosphatidylinositol binding IBA --
genes like me logo Genes that share ontologies with SNX7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNX7 Gene

Localization for SNX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX7 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX7 Gene COMPARTMENTS Subcellular localization image for SNX7 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SNX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0016020 membrane --
GO:0019898 extrinsic component of membrane IBA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with SNX7: view

Pathways for SNX7 Gene

SuperPathways for SNX7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport --
GO:0006897 endocytosis IBA --
GO:0006915 apoptotic process --
GO:0015031 protein transport IEA --
GO:0016050 vesicle organization IBA --
genes like me logo Genes that share ontologies with SNX7: view

No data available for Pathways by source for SNX7 Gene

Transcripts for SNX7 Gene

Unigene Clusters for SNX7 Gene

Sorting nexin 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: -

Relevant External Links for SNX7 Gene

GeneLoc Exon Structure for
SNX7
ECgene alternative splicing isoforms for
SNX7

Expression for SNX7 Gene

mRNA expression in normal human tissues for SNX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX7 Gene

SOURCE GeneReport for Unigene cluster for SNX7 Gene Hs.197015

genes like me logo Genes that share expressions with SNX7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX7 Gene

Orthologs for SNX7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX7 35
  • 99.33 (n)
  • 99.11 (a)
SNX7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX7 35
  • 91.33 (n)
  • 92.89 (a)
SNX7 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX7 35
  • 93.01 (n)
  • 95.65 (a)
SNX7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx7 35
  • 84.76 (n)
  • 90.09 (a)
Snx7 16
Snx7 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX7 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX7 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx7 35
  • 86.27 (n)
  • 92.49 (a)
chicken
(Gallus gallus)
Aves SNX7 35
  • 76.98 (n)
  • 77.58 (a)
SNX7 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX7 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6955 35
tropical clawed frog
(Silurana tropicalis)
Amphibia snx7 35
  • 70.72 (n)
  • 73.03 (a)
Str.3486 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13759 35
snx7 35
  • 64.57 (n)
  • 63.35 (a)
snx7 36
  • 55 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX4 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9288 36
  • 36 (a)
OneToMany
Species with no ortholog for SNX7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX7 Gene

ENSEMBL:
Gene Tree for SNX7 (if available)
TreeFam:
Gene Tree for SNX7 (if available)

Paralogs for SNX7 Gene

Paralogs for SNX7 Gene

Selected SIMAP similar genes for SNX7 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SNX7 Gene

genes like me logo Genes that share paralogs with SNX7: view

Variants for SNX7 Gene

Sequence variations from dbSNP and Humsavar for SNX7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs992708 -- 98,744,171(-) GCCAA(A/G)TTTTC intron-variant
rs993216 -- 98,740,717(-) ACAGC(A/G)ATGCT intron-variant
rs993217 -- 98,740,436(-) GCATG(C/T)TTTAA intron-variant
rs1384157 -- 98,760,921(-) ATAAA(C/T)GAATG downstream-variant-500B
rs1384158 -- 98,741,066(-) TCTGA(C/T)ATTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX7 Gene

Variant ID Type Subtype PubMed ID
nsv830747 CNV Loss 17160897
esv2715240 CNV Deletion 23290073
esv2662446 CNV Deletion 23128226
esv2715252 CNV Deletion 23290073
esv2670043 CNV Deletion 23128226
nsv830760 CNV Gain 17160897
nsv2065 CNV Loss 18451855

Relevant External Links for SNX7 Gene

HapMap Linkage Disequilibrium report
SNX7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX7 Gene

Disorders for SNX7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SNX7 Gene including...

Search for SNX7 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SNX7 Gene

Relevant External Links for SNX7

Genetic Association Database (GAD)
SNX7
genes like me logo Genes that share disorders with SNX7: view

No data available for UniProtKB/Swiss-Prot for SNX7 Gene

Publications for SNX7 Gene

  1. New locus for hereditary spastic paraplegia maps to chromosome 1p31.1-1p21.1. (PMID: 16130112) Orlacchio A. … Bernardi G. (Ann. Neurol. 2005) 3 23
  2. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale R.D. … Gleeson P.A. (Biochem. J. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. (PMID: 21873549) Strawbridge R.J. … Florez J.C. (Diabetes 2011) 3 48
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for SNX7 Gene

Sources for SNX7 Gene

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