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Aliases for SNX6 Gene

Aliases for SNX6 Gene

  • Sorting Nexin 6 2 3
  • TRAF4-Associated Factor 2 3 4
  • Tumor Necrosis Factor Receptor-Associated Factor 4(TRAF4)-Associated Factor 2 3
  • Sorting Nexin-6 3
  • MSTP010 3
  • TFAF2 3

External Ids for SNX6 Gene

Summaries for SNX6 Gene

Entrez Gene Summary for SNX6 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX6 Gene

SNX6 (Sorting Nexin 6) is a Protein Coding gene. Among its related pathways are TGF-beta Receptor Signaling Pathway and SMAD Signaling Network. GO annotations related to this gene include protein homodimerization activity and phosphatidylinositol binding. An important paralog of this gene is SNX5.

UniProtKB/Swiss-Prot for SNX6 Gene

  • Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX6 Gene

Genomics for SNX6 Gene

Genomic Location for SNX6 Gene

Start:
34,561,094 bp from pter
End:
34,630,183 bp from pter
Size:
69,090 bases
Orientation:
Minus strand

Genomic View for SNX6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX6 Gene

Regulatory Elements for SNX6 Gene

Proteins for SNX6 Gene

  • Protein details for SNX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNH7-SNX6_HUMAN
    Recommended name:
    Sorting nexin-6
    Protein Accession:
    Q9UNH7
    Secondary Accessions:
    • C0H5W9
    • Q9Y449

    Protein attributes for SNX6 Gene

    Size:
    406 amino acids
    Molecular mass:
    46649 Da
    Quaternary structure:
    • Forms heterodimers with BAR domain-containing sorting nexins SNX1 and SNX2 (PubMed:23085988). The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also descibed as vacuolar protein sorting subcomplex (VPS), and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity (Probable). Interacts with SNX1, SNX2, VPS26A, VPS29, VPS35, CDKN1B, TGFB receptors, BACE1, BRMS1, PIP5K1C isoform 3. Interacts with DCTN1; the association with DCTN1 is involved in movement of retromer-c ontaining vesicles toward the TGN (PubMed:11279102, PubMed:17148574, PubMed:19935774, PubMed:19619496, PubMed:20354142, PubMed:20830743, PubMed:23085988, PubMed:24610942). Interacts with CDKN1B and GIT1 (By similarity). Interacts with PIM1; translocating SNX6 to the nucleus (PubMed:11591366).
    SequenceCaution:
    • Sequence=AAD24202.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SNX6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX6 Gene

Proteomics data for SNX6 Gene at MOPED

Post-translational modifications for SNX6 Gene

  • In vitro phosphorylated by PIM1; not affecting PIM1-dependent nuclear translocation (PubMed:11591366).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys60, Lys119, Lys138, Lys189, Lys204, Lys265, Lys291, and Lys375

No data available for DME Specific Peptides for SNX6 Gene

Domains for SNX6 Gene

Gene Families for SNX6 Gene

HGNC:
  • SNX :Sorting nexins

Protein Domains for SNX6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNH7

UniProtKB/Swiss-Prot:

SNX6_HUMAN
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate.:
    • Q9UNH7
  • The BAR domain is able to sense membrane curvature upon dimerization. Membrane remodeling seems to implicate insertion of an amphipatric helix (AH) in the membrane (Probable).:
    • Q9UNH7
  • Contains 1 BAR domain.:
    • Q9UNH7
  • Contains 1 PX (phox homology) domain.:
    • Q9UNH7
Family:
  • Belongs to the sorting nexin family.:
    • Q9UNH7
genes like me logo Genes that share domains with SNX6: view

Function for SNX6 Gene

Molecular function for SNX6 Gene

UniProtKB/Swiss-Prot Function: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).

Gene Ontology (GO) - Molecular Function for SNX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278302
GO:0034452 dynactin binding IDA 19619496
GO:0034713 type I transforming growth factor beta receptor binding --
GO:0035091 phosphatidylinositol binding IBA --
GO:0042803 protein homodimerization activity IPI 11279102
genes like me logo Genes that share ontologies with SNX6: view
genes like me logo Genes that share phenotypes with SNX6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNX6 Gene

Localization for SNX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX6 Gene

Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Nucleus. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus. {ECO:0000269 PubMed:19935774}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX6 Gene COMPARTMENTS Subcellular localization image for SNX6 gene
Compartment Confidence
endosome 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SNX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 11279102
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 11279102
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0019898 extrinsic component of membrane IBA --
genes like me logo Genes that share ontologies with SNX6: view

Pathways for SNX6 Gene

genes like me logo Genes that share pathways with SNX6: view

Pathways by source for SNX6 Gene

1 Qiagen pathway for SNX6 Gene
1 BioSystems pathway for SNX6 Gene

Gene Ontology (GO) - Biological Process for SNX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport NAS 11279102
GO:0006897 endocytosis IBA --
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity NAS 11279102
GO:0016050 vesicle organization IBA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 11279102
genes like me logo Genes that share ontologies with SNX6: view

Transcripts for SNX6 Gene

Unigene Clusters for SNX6 Gene

Sorting nexin 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX6 Gene

No ASD Table

Relevant External Links for SNX6 Gene

GeneLoc Exon Structure for
SNX6
ECgene alternative splicing isoforms for
SNX6

Expression for SNX6 Gene

mRNA expression in normal human tissues for SNX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX6 Gene

SOURCE GeneReport for Unigene cluster for SNX6 Gene Hs.356647

genes like me logo Genes that share expressions with SNX6: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX6 Gene

Orthologs for SNX6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX6 35
  • 99.68 (n)
  • 99.76 (a)
SNX6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX6 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
SNX6 35
  • 95.32 (n)
  • 99.75 (a)
mouse
(Mus musculus)
Mammalia Snx6 35
  • 90.64 (n)
  • 99.51 (a)
Snx6 16
Snx6 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX6 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX6 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx6 35
  • 90.64 (n)
  • 99.51 (a)
chicken
(Gallus gallus)
Aves SNX6 35
  • 86.29 (n)
  • 97.04 (a)
SNX6 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX6 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx6 35
  • 78.63 (n)
  • 93.56 (a)
zebrafish
(Danio rerio)
Actinopterygii snx6 35
  • 77.09 (n)
  • 92.36 (a)
snx6 36
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004487 35
  • 58 (n)
  • 58.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Snx6 35
  • 55.39 (n)
  • 53.58 (a)
Snx6 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snx-6 35
  • 60.09 (n)
  • 54.74 (a)
snx-6 36
  • 44 (a)
OneToMany
Y59A8B.22 37
  • 35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15264 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5377 36
  • 46 (a)
OneToMany
Species with no ortholog for SNX6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX6 Gene

ENSEMBL:
Gene Tree for SNX6 (if available)
TreeFam:
Gene Tree for SNX6 (if available)

Paralogs for SNX6 Gene

Paralogs for SNX6 Gene

Selected SIMAP similar genes for SNX6 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for SNX6 Gene

genes like me logo Genes that share paralogs with SNX6: view

Variants for SNX6 Gene

Sequence variations from dbSNP and Humsavar for SNX6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs3958 -- 34,601,165(+) GCTTC(A/G)GAAGA intron-variant
rs4858 -- 34,568,655(-) CTCAT(C/T)CGT intron-variant
rs9264 -- 34,562,963(-) CGCAC(A/G)CCCAG utr-variant-3-prime
rs10393 -- 34,568,664(-) ATAAA(C/T)TGCCT intron-variant
rs11007 -- 34,562,926(+) ACACA(C/G)TGCGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SNX6 Gene

Variant ID Type Subtype PubMed ID
nsv7251 OTHER Inversion 18451855
esv1007795 OTHER Inversion 20482838
nsv499102 OTHER Inversion 21111241
nsv93 OTHER Inversion 15895083
nsv523334 CNV Loss 19592680

Relevant External Links for SNX6 Gene

HapMap Linkage Disequilibrium report
SNX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX6 Gene

Disorders for SNX6 Gene

(1) University of Copenhagen DISEASES for SNX6 Gene

genes like me logo Genes that share disorders with SNX6: view

No data available for UniProtKB/Swiss-Prot for SNX6 Gene

Publications for SNX6 Gene

  1. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. (PMID: 11279102) Parks W.T. … Lechleider R.J. (J. Biol. Chem. 2001) 2 3 4 23
  2. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale R.D. … Gleeson P.A. (Biochem. J. 2001) 3 4 23
  3. Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6. (PMID: 16730713) Yoon T. … Lee K. (FEBS Lett. 2006) 3 23
  4. An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. (PMID: 18523162) Cavet M.E. … Berk B.C. (FASEB J. 2008) 3 23
  5. Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus. (PMID: 11591366) Ishibashi Y. … Iguchi-Ariga S.M. (FEBS Lett. 2001) 3 4

Products for SNX6 Gene

Sources for SNX6 Gene

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