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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNX6 Gene

protein-coding   GIFtS: 57
GCID: GC14M035030

sorting nexin 6
 Explore 5 diseases affiliated with
SNX6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNX6    

Aliases
for SNX6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sorting Nexin 61 2
TRAF4-Associated Factor 22 3
MSTP0102
TFAF22
Sorting Nexin-62
Tumor Necrosis Factor Receptor-Associated Factor 4(TRAF4)-Associated Factor 22

External Ids:    HGNC: 149701   Entrez Gene: 585332   Ensembl: ENSG000001295157   OMIM: 6060985   UniProtKB: Q9UNH73   

Export aliases for SNX6 gene to outside databases

Previous GC identifers: GC14M032408 GC14M028818 GC14M033020 GC14M034100 GC14M015145


Summaries
for SNX6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SNX6:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a
phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long
isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and
with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein
may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled
coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to
proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SNX6_HUMAN, Q9UNH7
Function: May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B (By
similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as
link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface
to the trans-Golgi network. May contribute to transcription regulation




Genomic Views
for SNX6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNX6 gene promoter:
         SRY   Nkx2-2   COUP   Lmo2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNX6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNX6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.1   Ensembl cytogenetic band:  14q13.1   HGNC cytogenetic band: 14q13

SNX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M035030:  view genomic region     (about GC identifiers)

Start:
 35,030,300 bp from pter      End:
 35,099,389 bp from pter
Size:
 69,090 bases      Orientation:
 minus strand

Proteins
for SNX6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SNX6_HUMAN, Q9UNH7 (See protein sequence)
Recommended Name: Sorting nexin-6  
Size: 406 amino acids; 46649 Da
Subunit: Interacts with CDKN1B (By similarity). Interacts with TGFB receptors. Interacts with dynactin subunit DCTN1.
Interacts with SNX1 and SNX2. Interacts with BACE1 and BRMS1
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome
membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus. Note=Interaction with SNX1 or SNX2
promotes location at endosome membranes. Only a minor proportion is seen in the nucleus
Sequence caution: Sequence=AAD24202.1; Type=Erroneous initiation;
Secondary accessions: C0H5W9 Q9Y449
Alternative splicing: 2 isoforms:  Q9UNH7-1   Q9UNH7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SNX6: NX_Q9UNH7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNH7

    • SNX6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_689419.2  NP_067072.3  

    ENSEMBL proteins: 
     ENSP00000379779   ENSP00000355217   ENSP00000452231   ENSP00000452082   ENSP00000451415  
     ENSP00000452577   ENSP00000450863   ENSP00000452520   ENSP00000379785   ENSP00000347230  

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    Novus Biologicals SNX6 Protein
    Novus Biologicals SNX6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SNX6

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS11279102
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA11279102
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031901early endosome membrane IDA19935774


    SNX6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SNX6

    Protein Domains /
    Families
    for SNX6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNX6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001683 Phox
     IPR015404 Vps5_C
     IPR014637 Snx5_Snx6

    Graphical View of Domain Structure for InterPro Entry Q9UNH7

    ProtoNet protein and cluster: Q9UNH7

    1 Blocks protein family: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SNX6_HUMAN, Q9UNH7
    Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or
    phosphatidylinositol 4,5-bisphosphate (By similarity)
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain


    Function
    for SNX6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SNX6_HUMAN, Q9UNH7
    Function: May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B (By
    similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as
    link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface
    to the trans-Golgi network. May contribute to transcription regulation

    miRNA
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    hsa-mir-1 (MIRT001331)

    OriGene 3'-UTR Clone (see all 2): SNX6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX6
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX6 (see all 52):
    hsa-miR-142-5p hsa-miR-642a hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-miR-570 hsa-let-7g hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmid: SNX6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX6 (see all 7)
    OriGene shRNA RFP: SNX6
    OriGene siRNA: SNX6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SNX6

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX6 (see all 4)
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11279102
    GO:0019904protein domain specific binding IEA--
    GO:0035091phosphatidylinositol binding IEA--
    GO:0042803protein homodimerization activity IPI11279102


    SNX6 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SNX6:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 


    Pathways & Interactions
    for SNX6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TGF-beta Receptor Signaling Pathway
    		TGF-beta Receptor Signaling Pathway1.00
    2SMAD Signaling Network
    		SMAD Signaling Network1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SNX6
        SMAD Signaling Network

    1 BioSystems Pathway for SNX6 
        TGF-beta Receptor Signaling Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNX6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for SNX6 (Q9UNH71, 2, 3 ENSP000003552174) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    ATP1A1P050232, 3, ENSP000002955984MINT-2634538 I2D: score=1 STRING: ENSP00000295598
    SNX2O607493, ENSP000003688314I2D: score=7 STRING: ENSP00000368831
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport NAS11279102
    GO:0007154cell communication IEA--
    GO:0007175negative regulation of epidermal growth factor-activated receptor activity NAS11279102
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway IDA11279102
    GO:0042147retrograde transport, endosome to Golgi IMP19935774


    SNX6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNX6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNX6
    Search CenterWatch for drugs/clinical trials and news about SNX6 

    Transcripts
    for SNX6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNX6 gene (2 alternative transcripts): 
    NM_152233.2  NM_021249.3  

    Unigene Cluster for SNX6:

    Sorting nexin 6
    Hs.356647  [show with all ESTs]
    Unigene Representative Sequence: NM_021249
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396526(uc001wse.1 uc001wsf.1 uc010tpm.1) ENST00000362031
    ENST00000556162 ENST00000555416 ENST00000555541 ENST00000556712 ENST00000557265
    ENST00000557341 ENST00000556303 ENST00000555648 ENST00000396534 ENST00000355110(uc010amm.1)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX6
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX6 (see all 52):
    hsa-miR-142-5p hsa-miR-642a hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-miR-570 hsa-let-7g hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmid: SNX6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX6 (see all 7)
    OriGene shRNA RFP: SNX6
    OriGene siRNA: SNX6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX6
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SNX6 (NM_021249)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX6 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX6

    Additional cDNA sequence: 

    AF109364.1 AF121856.1 AK021456.1 AK124315.1 AK292250.1 AK296213.1 AK308464.1 U83194.1 

    24/28 DOTS entries (see all 28):

    DT.100674846  DT.75159062  DT.95252182  DT.95252180  DT.100809299  DT.120752454  DT.97853342  DT.120752582 
    DT.91909782  DT.120752439  DT.100674851  DT.95252177  DT.95252196  DT.101971904  DT.120752466  DT.92447785 
    DT.95252179  DT.95252213  DT.100847921  DT.120752485  DT.121501660  DT.75159132  DT.91997976  DT.92447794 

    24/482 AceView cDNA sequences (see all 482):

    BC001798 BM850413 AA702977 BE549733 AA164685 AI719049 AA708919 AI129280 
    AI079414 BM817934 BM831014 N91264 AA678747 AA232882 BX377312 AI128862 
    CN485177 BE549916 CB134613 CR594308 CD722398 AI305175 CR590030 AI446034 

    GeneLoc Exon Structure


    Expression
    for SNX6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNX6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCCTGGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SNX6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SNX6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNX6

    SOURCE GeneReport for Unigene cluster: Hs.356647
        SABiosciences Custom PCR Arrays for SNX6
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for SNX6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SNX6 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SNX61 sorting nexin 6 86.29(n)
    97.04(a)    		   771038  NM_001079757.1  NP_001073225.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SNX66
    		 --
    		 91(a)
    		 1 ↔ 1
    		 2(54769299-54791019)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BU915950.12   -- 78.19(n)    BU915950.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii snx61 sorting nexin 6 77.09(n)
    92.36(a)    		   567182  NM_001030217.1  NP_001025388.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Snx61 CG8282-PA 55.47(n)
    53.58(a)    		   34126  NM_135355.3  NP_609199.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y59A8B.223   -- 35(a)   V(17971863-17982666)   --


    ENSEMBL Gene Tree for SNX6 (if available)
    TreeFam Gene Tree for SNX6 (if available) 

    Paralogs
    for SNX6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNX6 gene
    SNX22  SNX12  SNX322  SNX52  
    2 SIMAP similar genes for SNX6 using alignment to 8 protein entries:     SNX6_HUMAN (see all proteins):
    SNX32    SNX5

    SNX6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SNX6
    PGOHUM00000234259


    Genomic Variants
    for SNX6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1215 NCBI SNPs in SNX6 are shown (see all 1215)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs454910961,2
    		--35031477(+) CCTGCC/TTCTGT 2 -- ut310--------
    rs1497520851,2
    		--35031701(+) TTATCA/GCTGTT 2 -- ut310--------
    rs1898802081,2
    		--35031850(+) AGTCTG/TATTAA 2 -- ut310--------
    rs1823932201,2
    		--35031857(+) TTAAGA/TTGCTT 2 -- ut310--------
    rs38408291,2
    		C,--35031936(-) TAAAG-/ATTGCC 2 -- ut312Minor allele frequency- A:0.25NA 4
    rs779427191,2
    		--35031936(+) GGCAAA/TCTTTA 2 -- ut310--------
    rs1873922821,2
    		--35032094(+) TATGAC/TGAGTG 2 -- ut310--------
    rs138261,2
    		C,F,A,H,--35032112(+) ATGGAC/TCACTG 2 -- ut31 ese322Minor allele frequency- T:0.40MN NS EA NA WA 2530
    rs1131333951,2
    		--35032122(+) GTCATG/CGGGAA 2 -- ut312Minor allele frequency- C:0.06CSA WA 120
    rs1455562901,2
    		--35032162(+) GCATCG/TCCTGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SNX6 (35030300 - 35099389 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SNX6
         2 Inversions: 37158 0439

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    Disorders / Diseases
    for SNX6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNX6 for disorders           About GeneDecksing

    OMIM gene information: 606098    OMIM disorders: --

    5 diseases for SNX6:    About MalaCards
    holoprosencephaly    coloboma    breast cancer    ataxia
    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for SNX6:
    Holoprosencephaly

    Export disorders for SNX6 gene to outside databases

    Publications
    for SNX6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNX6 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with SNX6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. (PubMed id 11279102)1, 2, 3, 9 Parks W.T.... Lechleider R.J. (2001)
    2. A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)1, 2, 9 Teasdale R.D.... Gleeson P.A. (2001)
    3. Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression. (PubMed id 20830743)1, 2 Rivera J.... Bravo J. (2010)
    4. Proteomic identification of sorting nexin 6 as a nega tive regulator of BACE1-mediated APP processing. (PubMed id 20354142)1, 2 Okada H....Kim T.W. (2010)
    5. The retromer component SNX6 interacts with dynactin p 150(Glued) and mediates endosome-to-TGN transport. (PubMed id 19935774)1, 2 Hong Z....Liu J.J. (2009)
    6. An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. (PubMed id 18523162)1, 9 Cavet M.E....Berk B.C. (2008)
    7. Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6. (PubMed id 16730713)1, 9 Yoon T....Lee K. (2006)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for SNX6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SNX6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58533 HGNC: 14970 AceView: SNX6 Ensembl:ENSG00000129515 euGenes: HUgn58533
    ECgene: SNX6 H-InvDB: SNX6

    Other Databases showing SNX6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SNX6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNX6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SNX6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SNX6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNX6 gene:
    Search GeneIP for patents involving SNX6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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