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Aliases for SNX6 Gene

Aliases for SNX6 Gene

  • Sorting Nexin 6 2 3 5
  • TRAF4-Associated Factor 2 3 4
  • Tumor Necrosis Factor Receptor-Associated Factor 4(TRAF4)-Associated Factor 2 3
  • MSTP010 3
  • TFAF2 3

External Ids for SNX6 Gene

Previous GeneCards Identifiers for SNX6 Gene

  • GC14M032408
  • GC14M028818
  • GC14M033020
  • GC14M034100
  • GC14M035030
  • GC14M015145

Summaries for SNX6 Gene

Entrez Gene Summary for SNX6 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX6 Gene

SNX6 (Sorting Nexin 6) is a Protein Coding gene. Among its related pathways are Endocytosis and SMAD Signaling Network. GO annotations related to this gene include protein homodimerization activity and type I transforming growth factor beta receptor binding. An important paralog of this gene is SNX5.

UniProtKB/Swiss-Prot for SNX6 Gene

  • Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX6 Gene

Genomics for SNX6 Gene

Regulatory Elements for SNX6 Gene

Promoters for SNX6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNX6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX6 Gene

Chromosome:
14
Start:
34,561,094 bp from pter
End:
34,630,183 bp from pter
Size:
69,090 bases
Orientation:
Minus strand

Genomic View for SNX6 Gene

Genes around SNX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX6 Gene

Proteins for SNX6 Gene

  • Protein details for SNX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNH7-SNX6_HUMAN
    Recommended name:
    Sorting nexin-6
    Protein Accession:
    Q9UNH7
    Secondary Accessions:
    • C0H5W9
    • Q9Y449

    Protein attributes for SNX6 Gene

    Size:
    406 amino acids
    Molecular mass:
    46649 Da
    Quaternary structure:
    • Forms heterodimers with BAR domain-containing sorting nexins SNX1 and SNX2 (PubMed:23085988). The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also descibed as vacuolar protein sorting subcomplex (VPS), and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity (Probable). Interacts with SNX1, SNX2, VPS26A, VPS29, VPS35, CDKN1B, TGFB receptors, BACE1, BRMS1, PIP5K1C isoform 3. Interacts with DCTN1; the association with DCTN1 is involved in movement of retromer-c ontaining vesicles toward the TGN (PubMed:11279102, PubMed:17148574, PubMed:19935774, PubMed:19619496, PubMed:20354142, PubMed:20830743, PubMed:23085988, PubMed:24610942). Interacts with CDKN1B and GIT1 (By similarity). Interacts with PIM1; translocating SNX6 to the nucleus (PubMed:11591366).
    SequenceCaution:
    • Sequence=AAD24202.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SNX6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX6 Gene

Proteomics data for SNX6 Gene at MOPED

Post-translational modifications for SNX6 Gene

  • In vitro phosphorylated by PIM1; not affecting PIM1-dependent nuclear translocation (PubMed:11591366).
  • Ubiquitination at Lys 60, Lys 119, Lys 189, Lys 204, Lys 265, Lys 291, and Lys 375
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SNX6 Gene

Domains & Families for SNX6 Gene

Gene Families for SNX6 Gene

Protein Domains for SNX6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNH7

UniProtKB/Swiss-Prot:

SNX6_HUMAN :
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate.
  • The BAR domain is able to sense membrane curvature upon dimerization. Membrane remodeling seems to implicate insertion of an amphipatric helix (AH) in the membrane (Probable).
  • Contains 1 BAR domain.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX6: view

Function for SNX6 Gene

Molecular function for SNX6 Gene

UniProtKB/Swiss-Prot Function:
Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).
genes like me logo Genes that share phenotypes with SNX6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX6 Gene

Localization for SNX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX6 Gene

Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Nucleus. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus. {ECO:0000269 PubMed:19935774}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX6 Gene COMPARTMENTS Subcellular localization image for SNX6 gene
Compartment Confidence
endosome 5
nucleus 4
cytosol 3
golgi apparatus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SNX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11279102
GO:0030904 retromer complex IDA 19619496
GO:0097422 tubular endosome IDA 19619496
genes like me logo Genes that share ontologies with SNX6: view

Pathways & Interactions for SNX6 Gene

genes like me logo Genes that share pathways with SNX6: view

Pathways by source for SNX6 Gene

1 BioSystems pathway for SNX6 Gene
1 KEGG pathway for SNX6 Gene
1 Qiagen pathway for SNX6 Gene

Gene Ontology (GO) - Biological Process for SNX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA,NAS 11279102
GO:0016050 vesicle organization IBA --
GO:0016241 regulation of macroautophagy NAS 26172538
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 11279102
genes like me logo Genes that share ontologies with SNX6: view

No data available for SIGNOR curated interactions for SNX6 Gene

Drugs & Compounds for SNX6 Gene

No Compound Related Data Available

Transcripts for SNX6 Gene

Unigene Clusters for SNX6 Gene

Sorting nexin 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX6 Gene

No ASD Table

Relevant External Links for SNX6 Gene

GeneLoc Exon Structure for
SNX6
ECgene alternative splicing isoforms for
SNX6

Expression for SNX6 Gene

mRNA expression in normal human tissues for SNX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNX6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX6 Gene



SOURCE GeneReport for Unigene cluster for SNX6 Gene Hs.356647

genes like me logo Genes that share expression patterns with SNX6: view

Protein tissue co-expression partners for SNX6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX6 Gene

Orthologs for SNX6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX6 36
  • 100 (a)
OneToOne
SNX6 35
  • 99.68 (n)
  • 99.76 (a)
cow
(Bos Taurus)
Mammalia SNX6 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
SNX6 35
  • 95.32 (n)
  • 99.75 (a)
mouse
(Mus musculus)
Mammalia Snx6 16
Snx6 36
  • 100 (a)
OneToOne
Snx6 35
  • 90.64 (n)
  • 99.51 (a)
oppossum
(Monodelphis domestica)
Mammalia SNX6 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX6 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx6 35
  • 90.64 (n)
  • 99.51 (a)
chicken
(Gallus gallus)
Aves SNX6 35
  • 86.29 (n)
  • 97.04 (a)
SNX6 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX6 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx6 35
  • 78.63 (n)
  • 93.56 (a)
zebrafish
(Danio rerio)
Actinopterygii snx6 36
  • 92 (a)
OneToOne
snx6 35
  • 77.09 (n)
  • 92.36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004487 35
  • 58 (n)
  • 58.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Snx6 36
  • 47 (a)
OneToMany
Snx6 35
  • 55.39 (n)
  • 53.58 (a)
worm
(Caenorhabditis elegans)
Secernentea snx-6 35
  • 60.09 (n)
  • 54.74 (a)
Y59A8B.22 37
  • 35 (a)
snx-6 36
  • 44 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15264 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5377 36
  • 46 (a)
OneToMany
Species with no ortholog for SNX6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX6 Gene

ENSEMBL:
Gene Tree for SNX6 (if available)
TreeFam:
Gene Tree for SNX6 (if available)

Paralogs for SNX6 Gene

Paralogs for SNX6 Gene

(2) SIMAP similar genes for SNX6 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for SNX6 Gene

genes like me logo Genes that share paralogs with SNX6: view

Variants for SNX6 Gene

Sequence variations from dbSNP and Humsavar for SNX6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs3958 -- 34,601,165(+) GCTTC(A/G)GAAGA intron-variant
rs4858 -- 34,568,655(-) CTCAT(C/T)CGT intron-variant
rs11007 -- 34,562,926(+) ACACA(C/G)TGCGG utr-variant-3-prime
rs3809451 -- 34,630,776(-) CCGTT(A/G)TTTGA upstream-variant-2KB
rs3809452 -- 34,630,391(-) CCTTT(A/G)GCCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNX6 Gene

Variant ID Type Subtype PubMed ID
nsv7251 OTHER Inversion 18451855
esv1007795 OTHER Inversion 20482838
nsv499102 OTHER Inversion 21111241
nsv93 OTHER Inversion 15895083
nsv523334 CNV Loss 19592680

Variation tolerance for SNX6 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX6 Gene

HapMap Linkage Disequilibrium report
SNX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX6 Gene

Disorders for SNX6 Gene

Relevant External Links for SNX6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX6

No disorders were found for SNX6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX6 Gene

Publications for SNX6 Gene

  1. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. (PMID: 11279102) Parks W.T. … Lechleider R.J. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. (PMID: 18523162) Cavet M.E. … Berk B.C. (FASEB J. 2008) 3 23
  3. Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6. (PMID: 16730713) Yoon T. … Lee K. (FEBS Lett. 2006) 3 23
  4. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale R.D. … Gleeson P.A. (Biochem. J. 2001) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SNX6 Gene

Sources for SNX6 Gene

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