Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNX6 Gene

protein-coding   GIFtS: 57
GCID: GC14M035030

Sorting Nexin 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sorting Nexin 61 2
TRAF4-Associated Factor 22 3
MSTP0102
TFAF22
Sorting Nexin-62
Tumor Necrosis Factor Receptor-Associated Factor 4(TRAF4)-Associated
Factor 22

External Ids:    HGNC: 149701   Entrez Gene: 585332   Ensembl: ENSG000001295157   OMIM: 6060985   UniProtKB: Q9UNH73   

Export aliases for SNX6 gene to outside databases

Previous GC identifers: GC14M032408 GC14M028818 GC14M033020 GC14M034100 GC14M015145


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNX6 Gene:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which
is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with
the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine
kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth
factor. This protein may form oligomeric complexes with family member proteins through interactions of both the
PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the
nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts
encoding two distinct isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for SNX6 Gene: 
SNX6 (sorting nexin 6) is a protein-coding gene. Diseases associated with SNX6 include holoprosencephaly, and coloboma. GO annotations related to this gene include phosphatidylinositol binding and protein homodimerization activity. An important paralog of this gene is SNX2.

UniProtKB/Swiss-Prot: SNX6_HUMAN, Q9UNH7
Function: May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B
(By similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May
function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from
the cell surface to the trans-Golgi network. May contribute to transcription regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNX6 gene promoter:
         SRY   Nkx2-2   COUP   Lmo2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNX6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNX6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.1   Ensembl cytogenetic band:  14q13.1   HGNC cytogenetic band: 14q13

SNX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M035030:  view genomic region     (about GC identifiers)

Start:
35,030,300 bp from pter      End:
35,099,389 bp from pter
Size:
69,090 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNX6_HUMAN, Q9UNH7 (See protein sequence)
Recommended Name: Sorting nexin-6  
Size: 406 amino acids; 46649 Da
Subunit: Interacts with CDKN1B (By similarity). Interacts with TGFB receptors. Interacts with dynactin subunit
DCTN1. Interacts with SNX1 and SNX2. Interacts with BACE1 and BRMS1
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome
membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus. Note=Interaction with SNX1 or SNX2
promotes location at endosome membranes. Only a minor proportion is seen in the nucleus
Sequence caution: Sequence=AAD24202.1; Type=Erroneous initiation;
Secondary accessions: C0H5W9 Q9Y449
Alternative splicing: 2 isoforms:  Q9UNH7-1   Q9UNH7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SNX6: NX_Q9UNH7

Explore proteomics data for SNX6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UNH7

  • SNX6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNX6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_689419.2  NP_067072.3  

    ENSEMBL proteins: 
     ENSP00000379779   ENSP00000355217   ENSP00000452231   ENSP00000452082   ENSP00000451415  
     ENSP00000452577   ENSP00000450863   ENSP00000452520   ENSP00000379785   ENSP00000347230  

    Human Recombinant Protein Products for SNX6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SNX6
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SNX6
    GenScript Custom Purified and Recombinant Proteins Services for SNX6
    Novus Biologicals SNX6 Protein
    Novus Biologicals SNX6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNX6 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS11279102
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA11279102
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031901early endosome membrane IDA19935774

    SNX6 for ontologies           About GeneDecksing



    SNX6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SNX6
    GenScript Custom Superior Antibodies Services for SNX6
    Novus Biologicals SNX6 Antibodies
    Abcam antibodies for SNX6
    Cloud-Clone Corp. Antibodies for SNX6 
    ThermoFisher Antibodies for SNX6
    LSBio Antibodies in human, mouse, rat for SNX6 

    Assay Products for SNX6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SNX6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNX6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNX6 
    Cloud-Clone Corp. CLIAs for SNX6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SNX: Sorting nexins

    4 InterPro protein domains:
     IPR015404 Vps5_C
     IPR027267 AH/BAR-dom
     IPR014637 Snx5_Snx6
     IPR001683 Phox

    Graphical View of Domain Structure for InterPro Entry Q9UNH7

    ProtoNet protein and cluster: Q9UNH7

    1 Blocks protein domain: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SNX6_HUMAN, Q9UNH7
    Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or
    phosphatidylinositol 4,5-bisphosphate (By similarity)
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain


    SNX6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNX6_HUMAN, Q9UNH7
    Function: May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B
    (By similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May
    function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from
    the cell surface to the trans-Golgi network. May contribute to transcription regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11278302
    GO:0035091phosphatidylinositol binding IEA--
    GO:0042803protein homodimerization activity IPI11279102
         
    SNX6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SNX6:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNX6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SNX6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNX6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNX6 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNX6:
    hsa-mir-1 (MIRT001331)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX6
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX6 (see all 52):
    hsa-miR-142-5p hsa-miR-642a hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-miR-570 hsa-let-7g hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidSNX6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SNX6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNX6
    Sirion Biotech Customized adenovirus for overexpression of SNX6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SNX6 (see all 12)
    OriGene ORF clones in mouse, rat for SNX6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNX6 (NM_021249)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX6
    Sirion Biotech Customized lentivirus for stable overexpression of SNX6 
                         Customized lentivirus expression plasmids for stable overexpression of SNX6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNX6
    Search LifeMap BioReagents cell lines for SNX6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SNX6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    2SMAD Signaling Network
    SMAD Signaling Network

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SNX6
        SMAD Signaling Network

    1 BioSystems Pathway for SNX6
        TGF-beta Receptor Signaling Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNX6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for SNX6 (Q9UNH71, 2, 3 ENSP000003552174) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    ATP1A1P050232, 3, ENSP000002955984MINT-2634538 I2D: score=1 STRING: ENSP00000295598
    SNX2O607493, ENSP000003688314I2D: score=7 STRING: ENSP00000368831
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport NAS11279102
    GO:0007154cell communication IEA--
    GO:0007175negative regulation of epidermal growth factor-activated receptor activity NAS11279102
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway IDA11279102
    GO:0042147retrograde transport, endosome to Golgi IMP19935774

    SNX6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNX6

    Search CenterWatch for drugs/clinical trials and news about SNX6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNX6 gene (2 alternative transcripts): 
    NM_152233.2  NM_021249.3  

    Unigene Cluster for SNX6:

    Sorting nexin 6
    Hs.356647  [show with all ESTs]
    Unigene Representative Sequence: NM_021249
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396526(uc001wse.1 uc001wsf.1 uc010tpm.1) ENST00000362031
    ENST00000556162 ENST00000555416 ENST00000555541 ENST00000556712 ENST00000557265
    ENST00000557341 ENST00000556303 ENST00000555648 ENST00000396534 ENST00000355110(uc010amm.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX6
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX6 (see all 52):
    hsa-miR-142-5p hsa-miR-642a hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-miR-570 hsa-let-7g hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidSNX6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SNX6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX6
    Clone
    Products:
         
    OriGene clones in human, mouse for SNX6 (see all 12)
    OriGene ORF clones in mouse, rat for SNX6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNX6 (NM_021249)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX6
    Sirion Biotech Customized lentivirus for stable overexpression of SNX6 
                         Customized lentivirus expression plasmids for stable overexpression of SNX6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNX6
    OriGene qSTAR qPCR primer pairs in human, mouse for SNX6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX6

    Additional mRNA sequence: 

    AF109364.1 AF121856.1 AK021456.1 AK124315.1 AK292250.1 AK296213.1 AK308464.1 U83194.1 

    24/28 DOTS entries (see all 28):

    DT.100674846  DT.75159062  DT.95252182  DT.95252180  DT.100809299  DT.120752454  DT.97853342  DT.120752582 
    DT.91909782  DT.120752439  DT.100674851  DT.95252177  DT.95252196  DT.101971904  DT.120752466  DT.92447785 
    DT.95252179  DT.95252213  DT.100847921  DT.120752485  DT.121501660  DT.75159132  DT.92447794  DT.95252181 

    24/482 AceView cDNA sequences (see all 482):

    CR623714 AI129280 AI719049 AI446034 AI371771 AI128862 BE217870 AA702977 
    AA902465 CB130242 AW137248 AI081307 AA670114 BM850413 AI872270 CB163293 
    BE549916 AA456488 NM_021249 BF476697 CR594308 CD515772 CB992804 BM817934 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNX6 expression in normal human tissues (normalized intensities)      SNX6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCCTGGTA
    SNX6 Expression
    About this image


    SNX6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod

    See SNX6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNX6

    SOURCE GeneReport for Unigene cluster: Hs.356647
        SABiosciences Custom PCR Arrays for SNX6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SNX6
    OriGene qSTAR qPCR primer pairs in human, mouse for SNX6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SNX6 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snx61 , 5 sorting nexin 61, 5 90.64(n)1
    99.51(a)1
      12 (23.46 cM)5
    721831  NM_026998.31  NP_081274.21 
     547463575 
    chicken
    (Gallus gallus)
    Aves SNX61 sorting nexin 6 86.29(n)
    97.04(a)
      771038  NM_001079757.1  NP_001073225.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNX66
    sorting nexin 6
    96(a)
    1 ↔ 1
    2(54755155-54792914)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU915950.12   -- 78.19(n)    BU915950.1 
    zebrafish
    (Danio rerio)
    Actinopterygii snx61 sorting nexin 6 77.09(n)
    92.36(a)
      567182  NM_001030217.1  NP_001025388.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Snx61 CG8282-PA 55.47(n)
    53.58(a)
      34126  NM_135355.3  NP_609199.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS56
    Nexin-1 homolog required for localizing membrane p...
    9(a)
    1 → many
    XV(453768-455795)


    ENSEMBL Gene Tree for SNX6 (if available)
    TreeFam Gene Tree for SNX6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNX6 gene
    SNX22  SNX12  SNX322  SNX52  
    2 SIMAP similar genes for SNX6 using alignment to 8 protein entries:     SNX6_HUMAN (see all proteins):
    SNX32    SNX5

    SNX6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SNX6
    PGOHUM00000234259


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1462 SNPs in SNX6 are shown (see all 1462)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862025851,2
    --15214582(+) AAATTA/TAAAAA 2 -- us2k10--------
    rs1910495921,2
    --15214583(+) AATTTA/TAAAAA 2 -- us2k10--------
    rs1824659461,2
    --15214750(+) GTTTCC/TCAGCG 2 -- us2k10--------
    rs101519591,2
    C,F,A,H--15214755(+) CCAGCA/GCATTG 2 -- us2k128Minor allele frequency- G:0.28NS EA NA WA CSA 2772
    rs1891086151,2
    --15214838(+) GTGTCA/GGGAGG 2 -- us2k10--------
    rs771528851,2
    C,F--15214845(+) GAGGAA/TTGTTC 2 -- us2k11Minor allele frequency- T:0.11WA 118
    rs1490571601,2
    --15214875(+) AAAAGG/TGCCAC 2 -- us2k10--------
    rs101411291,2
    C--15214881(+) GCCACA/TATTTC 2 -- us2k10--------
    rs49821921,2
    C,F,A,H--15214946(+) AGAGAA/GAGGAG 2 -- us2k1 trp326Minor allele frequency- G:0.27NS EA NA WA CSA 2437
    rs1386106291,2
    C--15214963(+) CACAAC/TAAATG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNX6 (35030300 - 35099389 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SNX6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523334CNV Loss19592680
    nsv93OTHER Inversion15895083
    nsv499102OTHER Inversion21111241
    nsv7251OTHER Inversion18451855
    esv1007795OTHER Inversion20482838

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SNX6
    DNA2.0 Custom Variant and Variant Library Synthesis for SNX6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606098    OMIM disorders: --

    4 diseases for SNX6:    About MalaCards
    holoprosencephaly    coloboma    schizophrenia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for SNX6:
    Holoprosencephaly

    SNX6 for disorders           About GeneDecksing


    Export disorders for SNX6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNX6 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with SNX6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. (PubMed id 11279102)1, 2, 3, 9 Parks W.T.... Lechleider R.J. (2001)
    2. A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)1, 2, 9 Teasdale R.D.... Gleeson P.A. (2001)
    3. Proteomic identification of sorting nexin 6 as a nega tive regulator of BACE1-mediated APP processing. (PubMed id 20354142)1, 2 Okada H....Kim T.W. (2010)
    4. Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression. (PubMed id 20830743)1, 2 Rivera J.... Bravo J. (2010)
    5. The retromer component SNX6 interacts with dynactin p 150(Glued) and mediates endosome-to-TGN transport. (PubMed id 19935774)1, 2 Hong Z....Liu J.J. (2009)
    6. An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. (PubMed id 18523162)1, 9 Cavet M.E....Berk B.C. (2008)
    7. Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6. (PubMed id 16730713)1, 9 Yoon T....Lee K. (2006)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58533 HGNC: 14970 AceView: SNX6 Ensembl:ENSG00000129515 euGenes: HUgn58533
    ECgene: SNX6 H-InvDB: SNX6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNX6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SNX6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNX6 gene:
    Search GeneIP for patents involving SNX6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SNX6  
     OriGene qPCR primer pairs and template standards for SNX6   OriGene Protein Over-expression Lysate for SNX6  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SNX6  
     OriGene qSTAR qPCR primer pairs in human, mouse for SNX6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SNX6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SNX6   OriGene Custom Protein Services for SNX6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX6
     QIAGEN SeqTarget long-range PCR primers for resequencing SNX6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX6
     GenScript Custom Purified and Recombinant Proteins Services for SNX6 GenScript cDNA clones with any tag delivered in your preferred vector for SNX6
     GenScript Custom Assay Services for SNX6 GenScript Custom Superior Antibodies Services for SNX6
     GenScript Custom overexpressing Cell Line Services for SNX6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SNX6 promoter
     Search Chromatin IP Primers for SNX6
     RT2 qPCR Primer Assay in human, mouse, rat SNX6
     GNC Network for SNX6
     SABiosciences PCR Arrays including human, mouse, rat SNX6
     Search Tocris compounds for SNX6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SNX6 antibodies
     SNX6 proteins
     SNX6 lysates
     Antibodies for SNX6
     See all of Abcam's Antibodies, Kits and Proteins for SNX6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SNX6
     Antibodies for SNX6
     ELISAs for SNX6
     CLIAs for SNX6
     Search LifeMap BioReagents cell lines for SNX6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX6
     SwitchGear 3'UTR luciferase reporter plasmids for SNX6
     SwitchGear Promoter luciferase reporter plasmids for SNX6
     ThermoFisher Antibodies for SNX6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SNX6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SNX6
    Customized:
     lentivirus for stable overexpression of SNX6
     lentivirus expression plasmids for stable overexpression of SNX6
     adenovirus for overexpression of SNX6
     LSBio Antibodies in human, mouse, rat for SNX6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SNX6 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4