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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNX5 Gene

protein-coding   GIFtS: 55
GCID: GC20M017870

sorting nexin 5
 Explore 3 diseases affiliated with
SNX5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNX5    

Aliases
for SNX5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sorting Nexin 51 2
Sorting Nexin-52

External Ids:    HGNC: 149691   Entrez Gene: 271312   Ensembl: ENSG000000890067   OMIM: 6059375   UniProtKB: Q9Y5X33   

Export aliases for SNX5 gene to outside databases

Previous GC identifers: GC20M017910 GC20M017917


Summaries
for SNX5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SNX5:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a
phosphoinositide binding domain, and are involved in intracellular trafficking. This protein binds to fanconi anemia
complementation group A protein, but its function is unknown. This gene results in two transcript variants encoding
the same protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SNX5_HUMAN, Q9Y5X3
Function: May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a
role in the internalization of EGFR after EGF stimulation

Gene Wiki entry for SNX5


Genomic Views
for SNX5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNX5 gene promoter:
         Egr-3   GR   Egr-1   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNX5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNX5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11   Ensembl cytogenetic band:  20p11.23   HGNC cytogenetic band: 20p11

SNX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M017870:  view genomic region     (about GC identifiers)

Start:
 17,922,241 bp from pter      End:
 17,949,623 bp from pter
Size:
 27,383 bases      Orientation:
 minus strand

Proteins
for SNX5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SNX5_HUMAN, Q9Y5X3 (See protein sequence)
Recommended Name: Sorting nexin-5  
Size: 404 amino acids; 46816 Da
Subunit: Interacts with SNX1; this promotes location at the endosome membrane
Subcellular location: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral
membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF
stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2). Detected on
macropinosomes. Targeted to membrane ruffles in response to EGFR stimulation
Caution: The selectivity for particular phosphatidylinositol lipids is under debate. According to one report
(PubMed:19553671), the rat protein binds exclusively to phosphatidylinositol 4,5-bisphosphate, while the human protein
has been reported (PubMed:15561769) to bind to phosphatidylinositol 3,4-bisphosphate and also to phosphatidylinositol
3-phosphate
1 PDB 3D structure from and Proteopedia for SNX5:
1SYS (3D)    
Secondary accessions: B7ZKN3 D3DW26 Q52LC4 Q9BWP0

Explore the universe of human proteins at neXtProt for SNX5: NX_Q9Y5X3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5X3

    • SNX5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_055241.1  NP_689413.1  

    ENSEMBL proteins: 
     ENSP00000366998   ENSP00000366988   ENSP00000404448   ENSP00000406731  
    Reactome Protein details: Q9Y5X3
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): SNX5
    OriGene Custom Protein Services for SNX5 
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    Novus Biologicals SNX5 Protein
    Novus Biologicals SNX5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SNX5

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0001891phagocytic cup IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031234extrinsic to internal side of plasma membrane IDA15561769
    GO:0031313extrinsic to endosome membrane IDA15561769


    SNX5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SNX5

    Protein Domains /
    Families
    for SNX5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNX5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001683 Phox
     IPR015404 Vps5_C
     IPR014637 Snx5_Snx6

    Graphical View of Domain Structure for InterPro Entry Q9Y5X3

    ProtoNet protein and cluster: Q9Y5X3

    1 Blocks protein family: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SNX5_HUMAN, Q9Y5X3
    Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or
    phosphatidylinositol 4,5-bisphosphate (By similarity)
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 PX (phox homology) domain


    Function
    for SNX5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SNX5_HUMAN, Q9Y5X3
    Function: May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a
    role in the internalization of EGFR after EGF stimulation

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX5
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX5 (see all 28):
    hsa-miR-520e hsa-miR-302d hsa-miR-302e hsa-miR-301a hsa-miR-519a hsa-miR-520a-3p hsa-miR-372 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SNX5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX5 (see all 7)
    OriGene shRNA RFP: SNX5
    Browse OriGene siRNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SNX5

    Clone
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    Search LifeMap BioReagents cell lines for SNX5

    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035091phosphatidylinositol binding ISS--


    SNX5 for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Snx5):
     homeostasis/metabolism  immune system 

    SNX5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SNX5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin derived vesicle budding
    		trans-Golgi Network Vesicle Budding1.00
    		Golgi Associated Vesicle Biogenesis0.89
    		Clathrin derived vesicle budding1.00
    2Membrane Trafficking
    		Membrane Trafficking1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SNX5
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding



    SNX5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/20 Interacting proteins for SNX5 (Q9Y5X32, 3 ENSP000003669884) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC37Q165432, 3MINT-8250988 I2D: score=2 
    DNAJB11Q9UBS42, 3MINT-8254287 I2D: score=2 
    HMOX2P305192, 3MINT-8258423 I2D: score=2 
    MESDC2Q146962, 3MINT-8262972 I2D: score=2 
    PFDN1O609252, 3MINT-8266051 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006907pinocytosis IDA18854019
    GO:0007154cell communication IEA--
    GO:0015031protein transport IEA--


    SNX5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNX5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNX5
    Search CenterWatch for drugs/clinical trials and news about SNX5 

    Transcripts
    for SNX5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNX5 gene (2 alternative transcripts): 
    NM_014426.2  NM_152227.1  

    Unigene Cluster for SNX5:

    Sorting nexin 5
    Hs.316890  [show with all ESTs]
    Unigene Representative Sequence: AK054634
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377768(uc002wqd.3 uc002wqe.3) ENST00000490175 ENST00000377759(uc002wqc.3 uc010zrt.1)
    ENST00000483485(uc002wqb.3) ENST00000484809 ENST00000491090 ENST00000476648
    ENST00000463050 ENST00000431277 ENST00000419004 ENST00000494401 ENST00000474883
    ENST00000475716 ENST00000469704 ENST00000481323 ENST00000486039

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): SNX5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX5
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX5 (see all 28):
    hsa-miR-520e hsa-miR-302d hsa-miR-302e hsa-miR-301a hsa-miR-519a hsa-miR-520a-3p hsa-miR-372 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SNX5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX5 (see all 7)
    OriGene shRNA RFP: SNX5
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX5
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SNX5 (NM_152227)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX5 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX5

    Additional cDNA sequence: 

    AF121855.1 AK001793.1 AK026227.1 AK054634.1 AK123903.1 AK129505.1 AK223308.1 AK296947.1 
    AK308017.1 BC000100.3 BC062638.1 BC064555.1 BC073171.1 BC093623.1 BC093980.1 BC143274.1 
    BT007191.1 

    24/34 DOTS entries (see all 34):

    DT.75146083  DT.100882192  DT.95294273  DT.100882188  DT.100882186  DT.100882182  DT.425250  DT.99964198 
    DT.100882196  DT.206168  DT.100038310  DT.95089675  DT.120812561  DT.100882178  DT.91776031  DT.120812519 
    DT.97855010  DT.100705160  DT.120636551  DT.91776027  DT.120812456  DT.120812462  DT.95372746  DT.95372748 

    24/614 AceView cDNA sequences (see all 614):

    CA444854 AF121855 AA825990 AA962668 CR621801 BE791524 BM986920 CR604525 
    BQ649314 BU957385 BI834833 BQ004093 BM846071 AI336014 BE278898 AA282578 
    AA705521 F04429 AU121853 CR591673 AA864886 AK001793 BQ772303 AA600123 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SNX5 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:                                                                                                                        
    SP2:              -           -     -     -                                                                                 
    SP3:                                                                                                                        
    SP4:                                                                                                        -               
    SP5:                                                                                                        -               


    ECgene alternative splicing isoforms for SNX5

    Expression
    for SNX5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTGTCAGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SNX5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See SNX5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNX5

    SOURCE GeneReport for Unigene cluster: Hs.316890
        SABiosciences Custom PCR Arrays for SNX5
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX5

    Orthologs
    for SNX5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SNX5 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Snx51 , 5 sorting nexin 51, 5 91.34(n)1
    98.27(a)1    		   2 (70.98 cM)5
    691781  NM_001199188.11  NP_001186117.11 
     1442501235 
    chicken
    (Gallus gallus)    		 Aves SNX51 sorting nexin 5 80.31(n)
    85.91(a)    		   416718  NM_001006178.1  NP_001006178.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SNX56
    		 --
    		 81(a)
    		 1 ↔ 1
    		 4(74423528-74445017)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC685512 hypothetical protein MGC68551 77.35(n)    BC061649.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.64952 Danio rerio mRNA similar to sorting nexin 5 (cDNA clone more 78.66(n)    BC044479.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG82823 intracellular protein transport 53(a)   28F3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y59A8B.223   -- 58(a)   V(17971863-17982666)   --


    ENSEMBL Gene Tree for SNX5 (if available)
    TreeFam Gene Tree for SNX5 (if available) 

    Paralogs
    for SNX5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNX5 gene
    SNX62  SNX22  SNX12  SNX322  
    2 SIMAP similar genes for SNX5 using alignment to 4 protein entries:     SNX5_HUMAN (see all proteins):
    SNX6    SNX32

    SNX5 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for SNX5
    PGOHUM00000239905 PGOHUM00000245967 PGOHUM00000249610


    Genomic Variants
    for SNX5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/741 NCBI SNPs in SNX5 are shown (see all 741)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1433983121,2
    		--17921771(+) GGAAAA/GGGATG 2 -- ds50010--------
    rs610042061,2
    		F,--17921834(+) AGGAGC/TGCACA 2 -- ds50011Minor allele frequency- T:0.09WA 118
    rs343993221,2
    		C,--17921874(+) ATACT-/GGGTTT 2 -- ds50012Minor allele frequency- G:0.25NA CSA 4
    rs1872342771,2
    		--17921883(+) TTGCAA/CTCCTA 2 -- ds50010--------
    rs1909615251,2
    		--17921910(+) CTGCTA/CATCTG 2 -- ds50010--------
    rs772985551,2
    		F,--17921919(+) TGACAG/AGAGGC 2 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1457388851,2
    		--17921924(+) GGAGGC/TGAACC 2 -- ds50010--------
    rs1120310651,2
    		--17921997(+) GCCCTG/ATGGTA 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1136676071,2
    		--17922103(+) AATGTC/TAAGAC 2 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1507048301,2
    		--17922118(+) ACAAAC/TTTCCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SNX5 (17922241 - 17949623 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SNX5: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SNX5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNX5 for disorders           About GeneDecksing

    OMIM gene information: 605937    OMIM disorders: --

    3 diseases for SNX5:    About MalaCards
    fanconi anemia, complementation group a    fanconi's anemia    anemia

    Human Genome Epidemiology (HuGE) Navigator: SNX5 (1 document)

    Export disorders for SNX5 gene to outside databases

    Publications
    for SNX5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNX5 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with SNX5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation. (PubMed id 15561769)1, 2, 9 Merino-Trigo A....Gleeson P.A. (2004)
    2. A role for SNX5 in the regulation of macropinocytosis. (PubMed id 18854019)1, 2, 9 Lim J.P....Gleeson P.A. (2008)
    3. SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein. (PubMed id 10600472)1, 3, 9 Otsuki T....Liu J.M. (1999)
    4. A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)1, 2, 9 Teasdale R.D.... Gleeson P.A. (2001)
    5. A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. (PubMed id 17148574)1, 3 Wassmer T....Cullen P.J. (2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    9. The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport. (PubMed id 18596235)1, 9 Hara S....Matsuda M. (2008)
    10. Visualisation of macropinosome maturation by the recruitment of sorting nexins. (PubMed id 16968745)2, 9 Kerr M.C....Teasdale R.D. (2006)

    External Searches for SNX5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SNX5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27131 HGNC: 14969 AceView: SNX5andZNF339 Ensembl:ENSG00000089006 euGenes: HUgn27131
    ECgene: SNX5 H-InvDB: SNX5

    Other Databases showing SNX5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SNX5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNX5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNX5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNX5 gene:
    Search GeneIP for patents involving SNX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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