Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SNX4 Gene

Aliases for SNX4 Gene

  • Sorting Nexin 4 2 3 5
  • ATG24B 3

External Ids for SNX4 Gene

Previous GeneCards Identifiers for SNX4 Gene

  • GC03M121915
  • GC03M125196
  • GC03M126447
  • GC03M126486
  • GC03M126648
  • GC03M122541

Summaries for SNX4 Gene

Entrez Gene Summary for SNX4 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for SNX4 Gene

SNX4 (Sorting Nexin 4) is a Protein Coding gene. Among its related pathways are TGF-beta Receptor Signaling Pathway and Endocytosis. GO annotations related to this gene include phosphatidylinositol binding and epidermal growth factor receptor binding. An important paralog of this gene is SNX7.

UniProtKB/Swiss-Prot for SNX4 Gene

  • May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.

Gene Wiki entry for SNX4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX4 Gene

Genomics for SNX4 Gene

Regulatory Elements for SNX4 Gene

Enhancers for SNX4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNX4 on UCSC Golden Path with GeneCards custom track

Promoters for SNX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNX4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX4 Gene

Chromosome:
3
Start:
125,446,644 bp from pter
End:
125,520,214 bp from pter
Size:
73,571 bases
Orientation:
Minus strand

Genomic View for SNX4 Gene

Genes around SNX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX4 Gene

Proteins for SNX4 Gene

  • Protein details for SNX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95219-SNX4_HUMAN
    Recommended name:
    Sorting nexin-4
    Protein Accession:
    O95219
    Secondary Accessions:
    • B3KMH0
    • B4DQV4
    • D3DNA3

    Protein attributes for SNX4 Gene

    Size:
    450 amino acids
    Molecular mass:
    51909 Da
    Quaternary structure:
    • Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2.

    Alternative splice isoforms for SNX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX4 Gene

Proteomics data for SNX4 Gene at MOPED

Post-translational modifications for SNX4 Gene

  • Ubiquitination at Lys 140, Lys 205, Lys 224, Lys 253, Lys 339, Lys 361, and Lys 376
  • Modification sites at PhosphoSitePlus

Other Protein References for SNX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNX4 Gene

Domains & Families for SNX4 Gene

Gene Families for SNX4 Gene

Protein Domains for SNX4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX4 Gene

Graphical View of Domain Structure for InterPro Entry

O95219

UniProtKB/Swiss-Prot:

SNX4_HUMAN :
  • The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX4: view

Function for SNX4 Gene

Molecular function for SNX4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.

Gene Ontology (GO) - Molecular Function for SNX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005158 insulin receptor binding IDA 9819414
GO:0005515 protein binding IPI 11278302
genes like me logo Genes that share ontologies with SNX4: view
genes like me logo Genes that share phenotypes with SNX4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX4 Gene

Localization for SNX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX4 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX4 Gene COMPARTMENTS Subcellular localization image for SNX4 gene
Compartment Confidence
cytoskeleton 5
endosome 5
plasma membrane 5
cytosol 2
golgi apparatus 2
nucleus 2
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SNX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 18253931
GO:0016020 membrane IDA 9819414
GO:0031901 early endosome membrane IDA 17994011
GO:0043234 protein complex IDA 9819414
genes like me logo Genes that share ontologies with SNX4: view

Pathways & Interactions for SNX4 Gene

genes like me logo Genes that share pathways with SNX4: view

Pathways by source for SNX4 Gene

1 BioSystems pathway for SNX4 Gene
1 KEGG pathway for SNX4 Gene

Gene Ontology (GO) - Biological Process for SNX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016050 vesicle organization IBA --
genes like me logo Genes that share ontologies with SNX4: view

No data available for SIGNOR curated interactions for SNX4 Gene

Drugs & Compounds for SNX4 Gene

No Compound Related Data Available

Transcripts for SNX4 Gene

Unigene Clusters for SNX4 Gene

Sorting nexin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: -
SP2:

Relevant External Links for SNX4 Gene

GeneLoc Exon Structure for
SNX4
ECgene alternative splicing isoforms for
SNX4

Expression for SNX4 Gene

mRNA expression in normal human tissues for SNX4 Gene

Protein differential expression in normal tissues from HIPED for SNX4 Gene

This gene is overexpressed in Heart (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX4 Gene



SOURCE GeneReport for Unigene cluster for SNX4 Gene Hs.507243

genes like me logo Genes that share expression patterns with SNX4: view

Protein tissue co-expression partners for SNX4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX4 Gene

Orthologs for SNX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNX4 35
  • 93.11 (n)
  • 93.56 (a)
SNX4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX4 35
  • 94.71 (n)
  • 98.01 (a)
SNX4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx4 35
  • 89.04 (n)
  • 94 (a)
Snx4 16
Snx4 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNX4 35
  • 100 (n)
  • 100 (a)
SNX4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx4 35
  • 88.15 (n)
  • 94 (a)
oppossum
(Monodelphis domestica)
Mammalia SNX4 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 9 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SNX4 35
  • 81.18 (n)
  • 90.55 (a)
SNX4 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX4 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10742 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7062 35
zebrafish
(Danio rerio)
Actinopterygii snx4 35
  • 73.82 (n)
  • 82.83 (a)
wufb92d09 35
snx4 36
  • 76 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5915 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX4 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for SNX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX4 Gene

ENSEMBL:
Gene Tree for SNX4 (if available)
TreeFam:
Gene Tree for SNX4 (if available)

Paralogs for SNX4 Gene

Paralogs for SNX4 Gene

genes like me logo Genes that share paralogs with SNX4: view

Variants for SNX4 Gene

Sequence variations from dbSNP and Humsavar for SNX4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1136146 -- 125,489,413(-) AACCC(A/C)GACAA nc-transcript-variant, reference, synonymous-codon
rs1136147 -- 125,447,678(-) TATAC(A/C)ATAAG nc-transcript-variant, utr-variant-3-prime
rs2333222 -- 125,481,526(+) tcacc(A/G)caacc intron-variant
rs2333223 -- 125,447,191(-) CTGGT(C/G)AGAAA nc-transcript-variant, utr-variant-3-prime
rs2333224 -- 125,515,244(+) ctact(C/T)aggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX4 Gene

Variant ID Type Subtype PubMed ID
nsv10311 CNV Gain 18304495
nsv829713 CNV Gain 17160897
nsv829714 CNV Gain 17160897
esv270723 CNV Insertion 20981092

Variation tolerance for SNX4 Gene

Residual Variation Intolerance Score: 12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SNX4 Gene

Disorders for SNX4 Gene

Relevant External Links for SNX4

Genetic Association Database (GAD)
SNX4
Human Genome Epidemiology (HuGE) Navigator
SNX4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX4

No disorders were found for SNX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX4 Gene

Publications for SNX4 Gene

  1. Identification of a family of sorting nexin molecules and characterization of their association with receptors. (PMID: 9819414) Haft C.R. … Taylor S.I. (Mol. Cell. Biol. 1998) 2 3 4 23 67
  2. SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment. (PMID: 17994011) Traer C.J. … Cullen P.J. (Nat. Cell Biol. 2007) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. I+-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor. (PMID: 24690921) Sakane H. … Shirataki H. (PLoS ONE 2014) 3

Products for SNX4 Gene

Sources for SNX4 Gene

Content