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SNX4 Gene

protein-coding   GIFtS: 57
GCID: GC03M125196

Sorting Nexin 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sorting Nexin 41 2
ATG24B2
Sorting Nexin-42

External Ids:    HGNC: 111751   Entrez Gene: 87232   Ensembl: ENSG000001145207   OMIM: 6059315   UniProtKB: O952193   

Export aliases for SNX4 gene to outside databases

Previous GC identifers: GC03M121915 GC03M126447 GC03M126486 GC03M126648 GC03M122541


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNX4 Gene:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which
is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with
the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor,
insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form
oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein
coding, have been found for this gene. (provided by RefSeq, Nov 2012)

GeneCards Summary for SNX4 Gene:
SNX4 (sorting nexin 4) is a protein-coding gene. Diseases associated with SNX4 include batten disease, and cystic fibrosis. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX30.

UniProtKB/Swiss-Prot: SNX4_HUMAN, O95219
Function: May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed
transferrin receptor and prevent its degradation

Gene Wiki entry for SNX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNX4 gene promoter:
         TBP   Elk-1   Brachyury   NRSF form 1   NRSF form 2   Evi-1   AREB6   Pax-3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNX4 promoter sequence
   Search Chromatin IP Primers for SNX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.2   Ensembl cytogenetic band:  3q21.2   HGNC cytogenetic band: 3q21.2

SNX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M125196:  view genomic region     (about GC identifiers)

Start:
125,165,494 bp from pter      End:
125,239,058 bp from pter
Size:
73,565 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SNX4_HUMAN, O95219 (See protein sequence)
Recommended Name: Sorting nexin-4  
Size: 450 amino acids; 51909 Da
Subunit: Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and
DYNC1I2
Secondary accessions: B3KMH0 D3DNA3

Explore the universe of human proteins at neXtProt for SNX4: NX_O95219

Explore proteomics data for SNX4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys140, Lys205, Lys224, Lys253, Lys339, Lys361, Lys376
  • Modification sites at PhosphoSitePlus

  • See SNX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003785.1  
    ENSEMBL proteins: 
     ENSP00000251775   ENSP00000420526   ENSP00000420175   ENSP00000440824  

    SNX4 Human Recombinant Protein Products:

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    Novus Biologicals SNX4 Proteins
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    Cloud-Clone Corp. Proteins for SNX4

    SNX4 Antibody Products:

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    Cloud-Clone Corp. CLIAs for SNX4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SNX: Sorting nexins

    1 InterPro protein domain:
     IPR001683 Phox

    Graphical View of Domain Structure for InterPro Entry O95219

    ProtoNet protein and cluster: O95219

    1 Blocks protein domain: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SNX4_HUMAN, O95219
    Domain: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane
    localization
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain


    SNX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNX4_HUMAN, O95219
    Function: May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed
    transferrin receptor and prevent its degradation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11278302
    GO:0035091phosphatidylinositol binding IMP17994011
         
    SNX4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SNX4:
     Decreased Hepatitis C virus re  Synthetic lethal with c-Myc af 

         1 MGI phenotypic allele for Snx4 (no phenotypes)

    SNX4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNX4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNX4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNX4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNX4

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNX4:
    hsa-mir-10a-5p (MIRT025597), hsa-mir-100-5p (MIRT048486), hsa-mir-125a-5p (MIRT021294)

    Block miRNA regulation of human, mouse, rat SNX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX4 (see all 38):
    hsa-miR-513a-5p hsa-miR-29a hsa-miR-374a hsa-miR-449a hsa-miR-218 hsa-miR-105 hsa-miR-124 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidSNX4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SNX4

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    GenScript: all cDNA clones in your preferred vector: SNX4 (NM_003794)
    Sino Biological Human cDNA Clone for SNX4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX4

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNX4_HUMAN, O95219: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also detected
    on a juxtanuclear endocytic recycling compartment (ERC)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endosome5
    cytosol2
    nucleus2
    golgi apparatus1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11279102
    GO:0005868cytoplasmic dynein complex IDA17994011
    GO:0031901early endosome membrane IDA17994011

    SNX4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNX4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway


    1 BioSystems Pathway for SNX4
        TGF-beta Receptor Signaling Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNX4
    Interactions:

        GeneGlobe Interaction Network for SNX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNX4 (O952191, 2, 3 ENSP000002517754) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BIN1O004991, 2, 3, ENSP000003167794EBI-724909,EBI-719094 MINT-58437 MINT-58440 MINT-58438 MINT-58439 I2D: score=4 STRING: ENSP00000316779
    AGKQ53H122, 3, ENSP000003475814MINT-65151 I2D: score=3 STRING: ENSP00000347581
    SNX2O607493, ENSP000003688314I2D: score=3 STRING: ENSP00000368831
    INSRP062133, ENSP000003038304I2D: score=2 STRING: ENSP00000303830
    SNX6Q9UNH73, ENSP000003552174I2D: score=2 STRING: ENSP00000355217
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IBA--
    GO:0006897endocytosis TAS9819414
    GO:0007154cell communication ----
    GO:0015031protein transport IMP17994011
    GO:0032456endocytic recycling IMP17994011

    SNX4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNX4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SNX4 gene: 
    NM_003794.3  

    Unigene Cluster for SNX4:

    Sorting nexin 4
    Hs.507243  [show with all ESTs]
    Unigene Representative Sequence: NM_003794
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251775(uc003eib.3 uc011bkf.2) ENST00000471751 ENST00000482965
    ENST00000473417 ENST00000465505 ENST00000536067
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX4 (see all 38):
    hsa-miR-513a-5p hsa-miR-29a hsa-miR-374a hsa-miR-449a hsa-miR-218 hsa-miR-105 hsa-miR-124 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidSNX4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNX4
    Predesigned siRNA for gene silencing in human, mouse, rat SNX4
    Clone
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    OriGene clones in human, mouse for SNX4 (see all 7)
    OriGene ORF clones in mouse, rat for SNX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNX4 (NM_003794)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNX4
    OriGene qSTAR qPCR primer pairs in human, mouse for SNX4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNX4
      QuantiTect SYBR Green Assays in human, mouse, rat SNX4
      QuantiFast Probe-based Assays in human, mouse, rat SNX4

    Additional mRNA sequence: 

    AF065485.1 AF130078.1 AK001835.1 AK298972.1 BC018762.1 NR_073435.1 

    9 DOTS entries:

    DT.214715  DT.95329781  DT.100793071  DT.100793072  DT.100026174  DT.100701685  DT.120867095  DT.120867062 
    DT.91804345 

    Selected AceView cDNA sequences (see all 201):

    BM837603 AW051709 BI859777 CF147210 H04186 CA335534 BC018762 BI753292 
    AV651215 BM711348 BG282221 CB159329 BU675853 N63608 AI253066 BQ938587 
    AK001835 AV715043 BE272609 N44484 BP341861 BM766192 NM_003794 CR596306 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SNX4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                                                                                      -               
    SP2:                                                                                                      


    ECgene alternative splicing isoforms for SNX4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATTTCAGG
    SNX4 Expression
    About this image

    SNX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507243
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SNX4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snx41 , 5 sorting nexin 41, 5 89.04(n)1
    94(a)1
      16 (23.77 cM)5
    691501  NM_080557.21  NP_542124.11 
     332514565 
    chicken
    (Gallus gallus)
    Aves SNX41 sorting nexin 4 81.18(n)
    90.55(a)
      424260  XM_004942954.1  XP_004943011.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNX46
    sorting nexin 4
    75(a)
    1 ↔ 1
    1(77772961-77824364)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.70622 Xenopus laevis transcribed sequence with moderate similarity more 78.12(n)    BX852584.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb92d092 Transcribed sequence with moderate similarity to protein more 75.03(n)    57043900 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNX46
    Sorting nexin, involved in retrieval of late-Golgi...
    20(a)
    1 → many
    X(378825-380096) YJL036W


    ENSEMBL Gene Tree for SNX4 (if available)
    TreeFam Gene Tree for SNX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNX4 gene
    SNX302  SNX72  SNX22  SNX12  

    SNX4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNX4 (see all 1531)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503336261,2
    C--125165030(+) AAAAA-/GTAAAAT 2 -- ds50010--------
    rs1478672641,2
    --125165079(+) TAAAAA/GCCAAT 2 -- ds50010--------
    rs729777041,2
    C,F--125165155(+) TTTAGG/ATTCAG 2 -- ds50013Minor allele frequency- A:0.06WA CSA 121
    rs1825195861,2
    --125165190(+) ATGGGC/TAAATT 2 -- ds50010--------
    rs98126841,2
    C,F,A,H--125165209(+) ctgggG/Aattcg 2 -- ds50018Minor allele frequency- A:0.07NS EA CSA WA 876
    rs1880639071,2
    C--125165259(+) ACCAAC/TAGCTA 2 -- ds50010--------
    rs1416690091,2
    --125165338(+) TTTGCA/GTTCAT 2 -- ds50010--------
    rs1126729631,2
    C--125165994(+) TAGAT-/CTGAGA 2 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.00CSA 2
    rs1922898831,2
    --125165997(+) ATCTGA/CGAAGT 2 -- ut31 nc-transcript-variant0--------
    rs23332231,2
    C,F,O,H--125166035(-) CTGGTC/GAGAAA 2 -- ut31 nc-transcript-variant18Minor allele frequency- N:0.00NS EA NA CSA WA 1566

    HapMap Linkage Disequilibrium report for SNX4 (125165494 - 125239058 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SNX4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270723CNV Insertion20981092
    nsv829713CNV Gain17160897
    nsv829714CNV Gain17160897
    nsv10311CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNX4
    DNA2.0 Custom Variant and Variant Library Synthesis for SNX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605931    OMIM disorders: --

    2 diseases for SNX4:    About MalaCards
    batten disease    cystic fibrosis

    1 disease from the University of Copenhagen DISEASES database for SNX4:
    Batten disease

    SNX4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SNX4
    Human Genome Epidemiology (HuGE) Navigator: SNX4 (1 document)

    Export disorders for SNX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNX4 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with SNX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of sorting nexin molecules and characterization of their association with receptors. (PubMed id 9819414)1, 2, 3, 9 Haft C.R.... Taylor S.I. (Mol. Cell. Biol. 1998)
    2. SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment. (PubMed id 17994011)1, 2, 9 Traer C.J.... Cullen P.J. (Nat. Cell Biol. 2007)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation. (PubMed id 21973056)1 van Weering J.R....Cullen P.J. (Traffic 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8723 HGNC: 11175 AceView: SNX4 Ensembl:ENSG00000114520 euGenes: HUgn8723
    ECgene: SNX4 H-InvDB: SNX4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNX4 gene:
    Search GeneIP for patents involving SNX4

    GeneCards and IP:
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