Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SNX33 Gene

protein-coding   GIFtS: 49
GCID: GC15P075940

Sorting Nexin 33

(Previous name: SH3 and PX domain containing 3)
(Previous symbol: SH3PX3)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sorting Nexin 331 2     SNX302 3
SH3PX31 2 3     SH3 And PX Domain-Containing Protein 32 3
SH3 And PX Domain Containing 31 2     Sorting Nexin-332
SH3PXD3C2 3     

External Ids:    HGNC: 284681   Entrez Gene: 2573642   Ensembl: ENSG000001735487   UniProtKB: Q8WV413   

Export aliases for SNX33 gene to outside databases

Previous GC identifers: GC15P073730 GC15P052697


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SNX33 Gene:
SNX33 (sorting nexin 33) is a protein-coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX9.

UniProtKB/Swiss-Prot: SNX33_HUMAN, Q8WV41
Function: Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via
its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell
divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the
cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this
then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the
formation of macropinosomes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNX33 gene promoter:
         SRF   p53   SRF (504 AA)   FOXO3   STAT5A   Tal-1beta   FOXO3b   FOXO3a   ITF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNX33 promoter sequence
   Search Chromatin IP Primers for SNX33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNX33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q23

SNX33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX33 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P075940:  view genomic region     (about GC identifiers)

Start:
75,940,247 bp from pter      End:
75,954,642 bp from pter
Size:
14,396 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SNX33_HUMAN, Q8WV41 (See protein sequence)
Recommended Name: Sorting nexin-33  
Size: 574 amino acids; 65265 Da
Subunit: Homodimer (via BAR domain). Interacts with ADAM15. Interacts with FASLG. Interacts (via SH3 domain) with
DNM1 and DNM2. Interacts with WASL
1 PDB 3D structure from and Proteopedia for SNX33:
4AKV (3D)    
Secondary accessions: B1NM17

Explore the universe of human proteins at neXtProt for SNX33: NX_Q8WV41

Explore proteomics data for SNX33 at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SNX33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_695003.1  
    ENSEMBL proteins: 
     ENSP00000311427   ENSP00000455436  

    SNX33 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SNX33
    OriGene Protein Over-expression Lysate for SNX33
    OriGene MassSpec for SNX33
    OriGene Custom Protein Services for SNX33
    GenScript Custom Purified and Recombinant Proteins Services for SNX33
    Novus Biologicals SNX33 Proteins
    Novus Biologicals SNX33 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNX33

     
    Search eBioscience for Proteins for SNX33 

     
    antibodies-online proteins for SNX33 (6 products) 

     
    antibodies-online peptides for SNX33

    SNX33 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SNX33
    Novus Biologicals SNX33 Antibodies
    Abcam antibodies for SNX33
    Cloud-Clone Corp. Antibodies for SNX33
    ThermoFisher Antibodies for SNX33
    antibodies-online antibodies for SNX33 (17 products) 

    SNX33 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SNX33
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNX33
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNX33
    Cloud-Clone Corp. CLIAs for SNX33
    Search eBioscience for ELISAs for SNX33 
    antibodies-online kits for SNX33 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR001452 SH3_domain
     IPR019497 Sorting_nexin_WASP-bd-dom
     IPR001683 Phox
     IPR014536 Snx9_subfam
     IPR028642 SNX33

    Graphical View of Domain Structure for InterPro Entry Q8WV41

    ProtoNet protein and cluster: Q8WV41

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001683 Phox-like


    UniProtKB/Swiss-Prot: SNX33_HUMAN, Q8WV41
    Domain: The PX and BAR domains mediate association with membranes and are required for membrane tubulation
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with SNX33           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNX33_HUMAN, Q8WV41
    Function: Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via
    its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell
    divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the
    cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this
    then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the
    formation of macropinosomes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16374509
    GO:0035091phosphatidylinositol binding IBA--
    GO:0042802identical protein binding IPI19487689
         
    Find genes that share ontologies with SNX33           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SNX33

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNX33:
    hsa-mir-21-5p (MIRT030989)

    Block miRNA regulation of human, mouse, rat SNX33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX33 (see all 18):
    hsa-miR-30c hsa-miR-15a hsa-miR-30d hsa-miR-650 hsa-miR-424 hsa-miR-30a hsa-miR-2115 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidSNX33 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNX33
    Predesigned siRNA for gene silencing in human, mouse, rat SNX33

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNX33

    Clone
    Products:
         
    OriGene clones in human, mouse for SNX33 (see all 7)
    OriGene ORF clones in mouse, rat for SNX33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNX33 (NM_153271)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX33

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNX33
    Browse ESI BIO Cell Lines and PureStem Progenitors for SNX33 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX33


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SNX33_HUMAN, Q8WV41: Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic
    vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic, but a minor proportion
    is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    endosome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IBA--
    GO:0005829cytosol IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IDA--
    GO:0019898extrinsic component of membrane IDA--
    GO:0030659cytoplasmic vesicle membrane IEA--

    Find genes that share ontologies with SNX33           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNX33
    Interactions:

        Search GeneGlobe Interaction Network for SNX33

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for SNX33 (Q8WV411, 2, 3 ENSP000003114274) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WASP427681, 2, 3, ENSP000003658914EBI-2481535,EBI-346375 MINT-7218827 MINT-7218778 MINT-7218860 I2D: score=1 STRING: ENSP00000365891
    ADAM15Q134441, 2, 3, ENSP000003494364EBI-2481535,EBI-77818 MINT-2792455 MINT-2792950 I2D: score=2 STRING: ENSP00000349436
    SNX9Q9Y5X11, 2, 3, ENSP000003760244EBI-2481535,EBI-77848 MINT-7218758 I2D: score=1 STRING: ENSP00000376024
    SNX33Q8WV411, 2EBI-2481535,EBI-2481535 MINT-7218744
    FASLGP480231, 3, ENSP000003566944EBI-2481535,EBI-495538 I2D: score=1 STRING: ENSP00000356694
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IMP--
    GO:0006886intracellular protein transport IBA--
    GO:0006897endocytosis IMP--
    GO:0007032endosome organization IMP--
    GO:0007067mitosis IEA--

    Find genes that share ontologies with SNX33           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNX33



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SNX33 gene: 
    NM_153271.1  

    Unigene Cluster for SNX33:

    Sorting nexin 33
    Hs.8705  [show with all ESTs]
    Unigene Representative Sequence: EF653821
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308527(uc002bau.3) ENST00000569152(uc002bav.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNX33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX33 (see all 18):
    hsa-miR-30c hsa-miR-15a hsa-miR-30d hsa-miR-650 hsa-miR-424 hsa-miR-30a hsa-miR-2115 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidSNX33 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNX33
    Predesigned siRNA for gene silencing in human, mouse, rat SNX33
    Clone
    Products:
         
    OriGene clones in human, mouse for SNX33 (see all 7)
    OriGene ORF clones in mouse, rat for SNX33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNX33 (NM_153271)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX33
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNX33
    OriGene qSTAR qPCR primer pairs in human, mouse for SNX33
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNX33
      QuantiTect SYBR Green Assays in human, mouse, rat SNX33
      QuantiFast Probe-based Assays in human, mouse, rat SNX33

    Additional mRNA sequence: 

    AK091291.1 AK126563.1 AL833039.1 BC018775.1 EF219141.1 EF653821.1 

    6 DOTS entries:

    DT.95159750  DT.97794405  DT.310553  DT.308197  DT.95165810  DT.96085281 

    Selected AceView cDNA sequences (see all 70):

    BX505950 CF126533 AI302319 AI904525 BQ945606 AI090012 AI570653 BQ025500 
    CA313051 CF131022 NM_153271 BQ446201 CB529630 AI864266 BU543393 BM707224 
    BU188796 BC018775 BQ010405 BU623559 BI869402 BE464841 BE538120 AW674670 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SNX33    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for SNX33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SNX33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTCCTCCT
    SNX33 Expression
    About this image

    SNX33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNX33 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8705

    UniProtKB/Swiss-Prot: SNX33_HUMAN, Q8WV41
    Tissue specificity: Detected in heart and pancreas

        Custom PCR Arrays for SNX33
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SNX33
    OriGene qSTAR qPCR primer pairs in human, mouse for SNX33
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNX33
    QuantiTect SYBR Green Assays in human, mouse, rat SNX33
    QuantiFast Probe-based Assays in human, mouse, rat SNX33
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SNX33 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snx331 , 5 sorting nexin 331, 5 88.68(n)1
    94.77(a)1
      9 (30.48 cM)5
    2354061  NM_175483.51  NP_780692.21 
     569172005 
    chicken
    (Gallus gallus)
    Aves SNX331 sorting nexin 33 81.62(n)
    84.31(a)
      415309  XM_003641813.2  XP_003641861.2 
    lizard
    (Anolis carolinensis)
    Reptilia SNX336
    sorting nexin 33
    81(a)
    1 ↔ 1
    GL343374.1(23675-48096)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.292782 Xenopus laevis transcribed sequence with weak similarity more 78.09(n)    BJ075402.1 
    zebrafish
    (Danio rerio)
    Actinopterygii snx331 sorting nexin 33 71.15(n)
    76.18(a)
      100001421  NM_001122855.2  NP_001116327.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SH3PX16
    SH3PX1
    32(a)
    1 → many
    3L(9703522-9706927)
    worm
    (Caenorhabditis elegans)
    Secernentea lst-41 lst-4 45.33(n)
    35.79(a)
      178361  NM_182290.3  NP_872090.1 


    ENSEMBL Gene Tree for SNX33 (if available)
    TreeFam Gene Tree for SNX33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SNX33 gene
    SNX92  SNX182  
    3 SIMAP similar genes for SNX33 using alignment to 3 protein entries:     SNX33_HUMAN (see all proteins):
    SH3GL2    SNX18    SNX9

    Find genes that share paralogs with SNX33           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SNX33
    PGOHUM00000234190


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SNX33 (see all 248)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740265201,2
    C,F--75939386(+) CAACAC/TGGAAC 1 -- us2k13Minor allele frequency- T:0.21WA CSA 122
    rs748415741,2
    C,F--75939428(+) GCAGAT/GGTAGA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1165413201,2
    F--75939642(+) GAGTCC/AGCGAC 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1171754911,2
    C,F--75940054(+) CGGAGG/TAGTAG 1 -- us2k11Minor allele frequency- T:0.10EA 120
    rs734392791,2
    C,F--75940274(+) GCTGCC/TTTCTC 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1865724691,2
    --75940431(+) AAACTA/CCAAAC 1 -- us2k10--------
    rs1379019271,2
    --75940465(+) AGGGTG/TGTGAT 1 -- us2k10--------
    rs786960251,2
    C,F--75940547(+) AGAGCA/CGGGTC 1 -- us2k11Minor allele frequency- C:0.10EA 120
    rs124389731,2
    C,H--75940589(+) GGCAAA/CCAAAA 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs790910921,2
    F--75940664(+) GGTTGG/AGGCTG 1 -- us2k11Minor allele frequency- A:0.11WA 118

    HapMap Linkage Disequilibrium report for SNX33 (75940247 - 75954642 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SNX33:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749894CNV Deletion23290073
    esv2749895CNV Deletion23290073
    dgv2416n71CNV Loss21882294
    dgv2415n71CNV Loss21882294
    nsv527186CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNX33
    DNA2.0 Custom Variant and Variant Library Synthesis for SNX33

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SNX33 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with SNX33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel sorting nexin modulates endocytic trafficking and alpha- secretase cleavage of the amyloid precursor protein. (PubMed id 18353773)1, 2, 3 Schobel S.... Lichtenthaler S.F. (J. Biol. Chem. 2008)
    2. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. (PubMed id 16374509)1, 2, 3 Kaerkkaeinen S.... Saksela K. (EMBO Rep. 2006)
    3. SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. (PubMed id 22718350)1, 2 Ma M.P. and Chircop M. (J. Cell. Sci. 2012)
    4. Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33. (PubMed id 20964629)1, 2 Dislich B....Lichtenthaler S.F. (Biochem. J. 2011)
    5. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    6. Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins. (PubMed id 19718658)1, 2 Kleino I.... Saksela K. (J. Cell. Biochem. 2009)
    7. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. (PubMed id 19487689)1, 2 Zhang J....Pei D. (J. Biol. Chem. 2009)
    8. The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding. (PubMed id 18419754)1, 2 Heiseke A....Nunziante M. (Traffic 2008)
    9. The Phox (PX) domain proteins and membrane traffic. (PubMed id 16782399)1, 3 Seet L.F. and Hong W. (Biochim. Biophys. Acta 2006)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 257364 HGNC: 28468 AceView: MGC32065 Ensembl:ENSG00000173548 euGenes: HUgn257364
    ECgene: SNX33 H-InvDB: SNX33

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SNX33 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SNX33 gene:
    Search GeneIP for patents involving SNX33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SNX33  
     OriGene qPCR primer pairs and template standards for SNX33   OriGene Protein Over-expression Lysate for SNX33  
     OriGene MassSpec for SNX33   OriGene clones in human, mouse for SNX33  
     OriGene qSTAR qPCR primer pairs in human, mouse for SNX33   OriGene Purified Protein for SNX33  
     OriGene ORF clones in mouse, rat for SNX33   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SNX33   OriGene Custom Protein Services for SNX33  

     
     
     Block miRNA regulation of human, mouse, rat SNX33 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SNX33
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNX33 Predesigned siRNA for gene silencing in human, mouse, rat SNX33
     QuantiFast Probe-based Assays in human, mouse, rat SNX33 QuantiTect SYBR Green Assays in human, mouse, rat SNX33
     Custom PCR Arrays for SNX33 Search Chromatin IP Primers for SNX33
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNX33  Search GeneGlobe Interaction Network for SNX33
     Regulatory tfbs in SNX33 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SNX33 GenScript cDNA clones with any tag delivered in your preferred vector for SNX33
     GenScript Custom Assay Services for SNX33 GenScript Custom overexpressing Cell Line Services for SNX33
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SNX33
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SNX33 antibodies
     SNX33 proteins
     SNX33 lysates
     Antibodies for SNX33
     See all of Abcam's Antibodies, Kits and Proteins for SNX33
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SNX33
     Antibodies for SNX33
     ELISAs for SNX33
     CLIAs for SNX33



     Browse ESI BIO Cell Lines and PureStem Progenitors for SNX33
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX33
     SwitchGear 3'UTR luciferase reporter plasmids for SNX33
     SwitchGear Promoter luciferase reporter plasmids for SNX33
     ThermoFisher Antibodies for SNX33
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX33
     Browse compounds at ApexBio
     Search Addgene for plasmids for SNX33
      Search eBioscience for proteins for SNX33
      Search eBioscience for elisas for SNX33
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SNX33
     antibodies-online antibodies for SNX33 (17 products)
     antibodies-online kits for SNX33 (4 products)
     antibodies-online peptides for SNX33
     antibodies-online proteins for SNX33 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SNX33 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4