SNX33 Gene
protein-coding GIFtS : 46
GCID: GC15 P075940
sorting nexin 33 (Previous name: SH3 and PX domain containing 3 ) (Previous symbol: SH3PX3 )
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Aliasesfor SNX33 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Sorting Nexin 33 1 2 SH3 And PX Domain Containing 31 2 SH3PX31 2 3 SH3 And PX Domain-Containing Protein 32 3 SH3PXD3C1 2 3 MGC320651 SNX301 2 3 Sorting Nexin-332
Export aliases for SNX33 gene to outside databases Previous GC identifers: GC15P073730 GC15P052697
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Summariesfor SNX33 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor SNX33 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SNX33 gene promoter: SRF p53 SRF (504 AA) FOXO3 STAT5A Tal-1beta FOXO3b FOXO3a ITF-2 En-1 Other transcription factors Search SABiosciences Chromatin IP Primers for SNX33 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SNX33
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q24.2 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q23 SNX33 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15P075940: view genomic region
(about GC identifiers )
Start:
75,940,247 bp from pter
End:
75,954,642 bp from pter
Size:
14,396 bases
Orientation:
plus strand
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Proteinsfor SNX33 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SNX33_HUMAN, Q8WV41 (See
protein sequence )Recommended Name: Sorting nexin-33 Size : 574 amino acids; 65265 Da
Subunit : Interacts with ADAM15. Interacts with FASLG
1 PDB 3D structure from and Proteopedia for SNX33 :4AKV (3D)
 Explore the universe of human proteins at neXtProt for SNX33: NX_Q8WV41 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8WV41 SNX33 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_695003.1 ENSEMBL proteins: ENSP00000311427 ENSP00000455436 Human Recombinant Protein Products: SNX33 Antibody Products: Assay Products for SNX33:
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Protein
Domains / Familiesfor SNX33 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SNX33 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8WV41 ProtoNet protein and cluster: Q8WV41
2 Blocks protein families : IPB001452 SH3 domain signature IPB001683 Phox-like UniProtKB/Swiss-Prot: SNX33_HUMAN, Q8WV41 Similarity : Belongs to the sorting nexin familySimilarity : Contains 1 BAR domainSimilarity : Contains 1 PX (phox homology) domainSimilarity : Contains 1 SH3 domain
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Functionfor SNX33 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SNX33 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SNX33OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SNX33 (NM_153271 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX33 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SNX33
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX33
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
SNX33 for ontologies About GeneDecksing
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Pathways & Interactionsfor SNX33 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX33 STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/13 Interacting proteins for SNX33 (Q8WV41 1 , 2 , 3 ENSP00000311427 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 13 )Interactant Interaction Details GeneCard External ID(s) WAS P42768 2 , 3 , ENSP00000365891 4 MINT-7218827 MINT-7218778 MINT-7218860 I2D:
score=1 STRING: ENSP00000365891 ADAM15 Q13444 2 , 3 , ENSP00000349436 4 MINT-2792455 MINT-2792950 I2D:
score=2 STRING: ENSP00000349436 SNX9 Q9Y5X1 2 , 3 , ENSP00000376024 4 MINT-7218758 I2D:
score=1 STRING: ENSP00000376024 FASLG P48023 1 , 3 , ENSP00000356694 4 EBI-2481535,EBI-495538 I2D:
score=1 STRING: ENSP00000356694 PAK2 Q13177 3 , ENSP00000314067 4 I2D:
score=1 STRING: ENSP00000314067
About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007154 cell communication
IEA --
SNX33 for ontologies About GeneDecksing
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Drugs & Compoundsfor SNX33 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SNX33 Search CenterWatch for drugs/clinical trials and news about SNX33
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Transcriptsfor SNX33 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SNX33 gene: NM_153271.1 Unigene Cluster for SNX33:
Sorting nexin 33 Hs.8705 [show with all ESTs ] Unigene Representative Sequence: EF653821 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000308527 (uc002bau.3 ) ENST00000569152 (uc002bav.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SNX33 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SNX33OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SNX33 (NM_153271 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX33 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SNX33
Additional cDNA sequence: AK091291.1 AK126563.1 AL833039.1 BC018775.1 EF219141.1 EF653821.1
6 DOTS entries : DT.95159750 DT.97794405
DT.310553 DT.308197 DT.95165810 DT.96085281 24/70 AceView cDNA sequences (see all 70 ):
AI302319 CA313051 BU543393 AI570653 BC018775 AI090012 CB529630 BM707224 NM_153271 BU188796 CF131022 AI864266 CF126533 BQ446201 BX505950 BQ025500 BQ945606 AI904525 AL048303 BQ010405 BF448592 BQ936370 AI344358 CO402330 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for SNX33 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 SP1 :         SP2 :        
ECgene alternative splicing isoforms for SNX33
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Expression for SNX33 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SNX33 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTCTCCTCCT
About this image SNX33 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See SNX33 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SNX33 SOURCE GeneReport for Unigene cluster: Hs.8705 SABiosciences Custom PCR Arrays for SNX33 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SNX33Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SNX33 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SNX33 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SNX33 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX33
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Orthologsfor SNX33 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for SNX33 gene from 6/21 species (see all 21 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
SNX331
sorting nexin 33
81.62(n) 84.31(a)
 
415309 XM_003641813.1 XP_003641861.1
lizard (Anolis carolinensis)
Reptilia
SNX336
--
83(a)
1 ↔ 1
GL343374.1(29127-44936)
African clawed frog (Xenopus laevis)
Amphibia
Xl.292782
Xenopus laevis transcribed sequence with weak similarity more
78.09(n)
 
BJ075402.1
zebrafish (Danio rerio)
Actinopterygii
snx331
sorting nexin 33
72.06(n) 77.82(a)
 
100001421 NM_001122855.2 NP_001116327.1
fruit fly (Drosophila melanogaster)
Insecta
SH3PX16
SH3PX1
32(a)
1 → many
3L(9703522-9706927)
worm (Caenorhabditis elegans)
Secernentea
lst-46
Lateral Signaling Target family member (lst-4)
29(a)
1 → many
IV(14060980-14069831)
ENSEMBL Gene Tree for SNX33 (if available)TreeFam Gene Tree for SNX33 (if available)
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Paralogsfor SNX33 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SNX33 gene SNX9 2 SNX18 2 3 SIMAP similar genes for SNX33 using alignment to 4 protein entries: SNX33_HUMAN (see all proteins ):SH3GL2 SNX18 SNX9
SNX33 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for SNX33 PGOHUM00000234190
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Genomic Variantsfor SNX33 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SNX33 (75940247 - 75954642 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for SNX33 1 CNV : 77008
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SNX33
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Disorders
/ Diseasesfor SNX33 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor SNX33 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SNX33 gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with SNX33) Utopia : connect your pdf to the dynamic world of online information
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. (PubMed id 16374509) 1 , 2 , 3 Kaerkkaeinen S.... Saksela K. (2006) Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924) 1 , 2 Voss M....Janssen O. (2009) Alternative splicing of ADAM15 regulates its interact ions with cellular SH3 proteins. (PubMed id 19718658) 1 , 2 Kleino I....Saksela K. (2009) A novel sorting nexin modulates endocytic trafficking and alpha- secretase cleavage of the amyloid precursor protein. (PubMed id 18353773) 1 , 3 Schobel S.... Lichtenthaler S.F. (2008) The Phox (PX) domain proteins and membrane traffic. (PubMed id 16782399) 1 , 3 Seet L.F. and Hong W. (2006) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Specific amino acids in the BAR domain allow homodime rization and prevent heterodimerization of sorting nexin 33. (PubMed id 20964629) 1 Dislich B....Lichtenthaler S.F. (2011) Sorting nexin 33 induces mammalian cell micronucleate d phenotype and actin polymerization by interacting with Wiskott-Aldrich syndro me protein. (PubMed id 19487689) 1 Zhang J....Pei D. (2009) The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding. (PubMed id 18419754) 1 Heiseke A....Nunziante M. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008)
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External Searches for SNX33 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SNX33 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SNX33 gene
(According to HUGE )
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Specialized Databases showing SNX33 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SNX33 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SNX33 gene: Search GeneIP for patents involving SNX33 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SNX33 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SNX33 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SNX33 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SNX33 OriGene Protein Over-expression Lysate for SNX33 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SNX33 OriGene 3'-UTR Clone for SNX33 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SNX33 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SNX33 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SNX33 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SNX33 OriGene Custom Protein Services for SNX33 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX33 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SNX33 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SNX33 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SNX33 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SNX33 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SNX33
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SNX33 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX33
Search ThermoFisher Antibodies for SNX33
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SNX33
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Aliases for SNX33
Databases for SNX33
Disorders / Diseases for SNX33
Domains / Families for SNX33
Drugs / Compounds for SNX33
Expression for SNX33
Function for SNX33
Genomic Views for SNX33
Intellectual Property for SNX33
Orthologs for SNX33
Paralogs for SNX33
Pathways / Interactions for SNX33
Products for SNX33
Proteins for SNX33
Publications for SNX33
Search Box for SNX33
Summaries for SNX33
Transcripts for SNX33
Variants for SNX33
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