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Aliases for SNX33 Gene

Aliases for SNX33 Gene

  • Sorting Nexin 33 2 3
  • SH3 And PX Domain-Containing Protein 3 3 4
  • SH3 And PX Domain Containing 3 2 3
  • SH3PXD3C 3 4
  • SH3PX3 3 4
  • SNX30 3 4
  • Sorting Nexin-33 3

External Ids for SNX33 Gene

Previous HGNC Symbols for SNX33 Gene

  • SH3PX3

Previous GeneCards Identifiers for SNX33 Gene

  • GC15P073730
  • GC15P075940
  • GC15P052697

Summaries for SNX33 Gene

GeneCards Summary for SNX33 Gene

SNX33 (Sorting Nexin 33) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX18.

UniProtKB/Swiss-Prot for SNX33 Gene

  • Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX33 Gene

Genomics for SNX33 Gene

Regulatory Elements for SNX33 Gene

Genomic Location for SNX33 Gene

Start:
75,647,906 bp from pter
End:
75,662,301 bp from pter
Size:
14,396 bases
Orientation:
Plus strand

Genomic View for SNX33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX33 Gene

Proteins for SNX33 Gene

  • Protein details for SNX33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV41-SNX33_HUMAN
    Recommended name:
    Sorting nexin-33
    Protein Accession:
    Q8WV41
    Secondary Accessions:
    • B1NM17

    Protein attributes for SNX33 Gene

    Size:
    574 amino acids
    Molecular mass:
    65265 Da
    Quaternary structure:
    • Homodimer (via BAR domain). Interacts with ADAM15. Interacts with FASLG. Interacts (via SH3 domain) with DNM1 and DNM2. Interacts with WASL.

    Three dimensional structures from OCA and Proteopedia for SNX33 Gene

neXtProt entry for SNX33 Gene

Proteomics data for SNX33 Gene at MOPED

Post-translational modifications for SNX33 Gene

Other Protein References for SNX33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNX33 Gene

Domains for SNX33 Gene

Protein Domains for SNX33 Gene

Suggested Antigen Peptide Sequences for SNX33 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV41

UniProtKB/Swiss-Prot:

SNX33_HUMAN :
  • Q8WV41
Domain:
  • The PX and BAR domains mediate association with membranes and are required for membrane tubulation.
  • Contains 1 BAR domain.
  • Contains 1 PX (phox homology) domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX33: view

No data available for Gene Families for SNX33 Gene

Function for SNX33 Gene

Molecular function for SNX33 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

Gene Ontology (GO) - Molecular Function for SNX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16374509
GO:0035091 phosphatidylinositol binding IBA --
GO:0042802 identical protein binding IPI 19487689
genes like me logo Genes that share ontologies with SNX33: view

miRNA for SNX33 Gene

miRTarBase miRNAs that target SNX33

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNX33 Gene

Localization for SNX33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX33 Gene

Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941). {ECO:0000269 PubMed:18353773, ECO:0000269 PubMed:21048941}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX33 Gene COMPARTMENTS Subcellular localization image for SNX33 gene
Compartment Confidence
cytosol 3
nucleus 3
endosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SNX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0005829 cytosol IDA 18353773
GO:0016020 membrane IDA 18353773
GO:0016023 cytoplasmic membrane-bounded vesicle IDA 22718350
GO:0019898 extrinsic component of membrane IDA 20964629
genes like me logo Genes that share ontologies with SNX33: view

Pathways for SNX33 Gene

SuperPathways for SNX33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 22718350
GO:0006886 intracellular protein transport IEA --
GO:0006897 endocytosis IMP 22718350
GO:0007032 endosome organization IMP 21048941
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with SNX33: view

No data available for Pathways by source for SNX33 Gene

Transcripts for SNX33 Gene

mRNA/cDNA for SNX33 Gene

Unigene Clusters for SNX33 Gene

Sorting nexin 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX33 Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for SNX33 Gene

GeneLoc Exon Structure for
SNX33
ECgene alternative splicing isoforms for
SNX33

Expression for SNX33 Gene

mRNA expression in normal human tissues for SNX33 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX33 Gene

SOURCE GeneReport for Unigene cluster for SNX33 Gene Hs.8705

mRNA Expression by UniProt/SwissProt for SNX33 Gene

Q8WV41-SNX33_HUMAN
Tissue specificity: Detected in heart and pancreas.
genes like me logo Genes that share expressions with SNX33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SNX33 Gene

Orthologs for SNX33 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX33 35
  • 99.42 (n)
  • 99.65 (a)
SNX33 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX33 35
  • 91.24 (n)
  • 95.27 (a)
SNX33 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX33 35
  • 90.58 (n)
  • 94.76 (a)
SNX33 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx33 35
  • 88.68 (n)
  • 94.77 (a)
Snx33 16
Snx33 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX33 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX33 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx33 35
  • 88.97 (n)
  • 95.3 (a)
chicken
(Gallus gallus)
Aves SNX33 35
  • 81.62 (n)
  • 84.31 (a)
SNX33 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX33 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29278 35
tropical clawed frog
(Silurana tropicalis)
Amphibia snx33 35
  • 70.63 (n)
  • 76.6 (a)
Str.2090 35
zebrafish
(Danio rerio)
Actinopterygii snx33 35
  • 71.15 (n)
  • 76.18 (a)
snx33 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta SH3PX1 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lst-4 35
  • 45.33 (n)
  • 35.79 (a)
lst-4 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for SNX33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX33 Gene

ENSEMBL:
Gene Tree for SNX33 (if available)
TreeFam:
Gene Tree for SNX33 (if available)

Paralogs for SNX33 Gene

Paralogs for SNX33 Gene

Selected SIMAP similar genes for SNX33 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SNX33 Gene

genes like me logo Genes that share paralogs with SNX33: view

Variants for SNX33 Gene

Sequence variations from dbSNP and Humsavar for SNX33 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs8609 -- 75,658,392(-) GGCAG(A/G)CAGAG utr-variant-3-prime
rs4073213 -- 75,656,284(+) CTGAT(C/T)GGGGC intron-variant
rs4073214 -- 75,656,330(+) AGGAA(A/G)GTAGG intron-variant
rs4886726 -- 75,658,261(+) GGATC(C/T)CAGGG utr-variant-3-prime
rs8036649 -- 75,659,004(+) CCCCA(A/G)GGAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SNX33 Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV Deletion 23290073
esv2749895 CNV Deletion 23290073
nsv527186 CNV Loss 19592680
dgv2415n71 CNV Loss 21882294
dgv2416n71 CNV Loss 21882294

Relevant External Links for SNX33 Gene

HapMap Linkage Disequilibrium report
SNX33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX33 Gene

Disorders for SNX33 Gene

No disorders were found for SNX33 Gene.

No data available for UniProtKB/Swiss-Prot for SNX33 Gene

Publications for SNX33 Gene

  1. A novel sorting nexin modulates endocytic trafficking and alpha- secretase cleavage of the amyloid precursor protein. (PMID: 18353773) Schobel S. … Lichtenthaler S.F. (J. Biol. Chem. 2008) 2 3 4
  2. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. (PMID: 16374509) Kaerkkaeinen S. … Saksela K. (EMBO Rep. 2006) 2 3 4
  3. The Phox (PX) domain proteins and membrane traffic. (PMID: 16782399) Seet L.F. … Hong W. (Biochim. Biophys. Acta 2006) 2 3
  4. The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding. (PMID: 18419754) Heiseke A. … Nunziante M. (Traffic 2008) 3 4
  5. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. (PMID: 19487689) Zhang J. … Pei D. (J. Biol. Chem. 2009) 3 4

Products for SNX33 Gene

Sources for SNX33 Gene

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