Aliases for SNX33 Gene
External Ids for SNX33 Gene
Previous HGNC Symbols for SNX33 Gene
Previous GeneCards Identifiers for SNX33 Gene
The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for SNX33 Gene
SNX33 (Sorting Nexin 33) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and phosphatidylinositol binding. An important paralog of this gene is SNX18.
UniProtKB/Swiss-Prot for SNX33 Gene
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.