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Aliases for SNX33 Gene

Aliases for SNX33 Gene

  • Sorting Nexin 33 2 3 5
  • SH3 And PX Domain-Containing Protein 3 3 4
  • SH3 And PX Domain Containing 3 2 3
  • SH3PXD3C 3 4
  • SH3PX3 3 4
  • SNX30 3 4
  • Sorting Nexin-33 3

External Ids for SNX33 Gene

Previous HGNC Symbols for SNX33 Gene

  • SH3PX3

Previous GeneCards Identifiers for SNX33 Gene

  • GC15P073730
  • GC15P075940
  • GC15P052697

Summaries for SNX33 Gene

Entrez Gene Summary for SNX33 Gene

  • The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for SNX33 Gene

SNX33 (Sorting Nexin 33) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and phosphatidylinositol binding. An important paralog of this gene is SNX18.

UniProtKB/Swiss-Prot for SNX33 Gene

  • Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX33 Gene

Genomics for SNX33 Gene

Regulatory Elements for SNX33 Gene

Enhancers for SNX33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F074888 0.2 ENCODE 29.9 -757.3 -757277 4.0 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 RPP25 ISLR SNX33 ENSG00000203392 EDC3 MPI LOC105370902 LOC441728 LOC732265 DNM1P49
GH15F075335 0.8 ENCODE 27.3 -311.7 -311686 2.0 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MAN2C1 SNX33 ENSG00000203392 FBXO22 SNUPN LOC105370902 DNM1P49 LOC441728 COMMD4 DNM1P35
GH15F074730 0.6 ENCODE 27.3 -916.8 -916843 1.7 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ISLR SNX33 ENSG00000203392 LOC732265 LOC105370902 LOC102723657 GOLGA6A PTPN9 ENSG00000260274 DNM1P34
GH15F075022 0.2 ENCODE 27.3 -623.8 -623777 2.4 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SCAMP5 ISLR SNX33 ENSG00000203392 FBXO22 LOC105370902 LOC441728 LOC732265 DNM1P49 GOLGA6A
GH15F075366 0.5 ENCODE 25.3 -279.2 -279152 3.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DNM1P35 FBXO22 ENSG00000260274 SNX33 SNUPN ENSG00000203392 PTPN9 LOC101929333 EDC3 SIN3A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SNX33 on UCSC Golden Path with GeneCards custom track

Promoters for SNX33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000127930 94 2401 ATF1 ARID4B SIN3A FEZF1 GLI4 DMAP1 ZNF48 ZNF2 ZNF121 GLIS2

Genomic Location for SNX33 Gene

Chromosome:
15
Start:
75,647,906 bp from pter
End:
75,662,301 bp from pter
Size:
14,396 bases
Orientation:
Plus strand

Genomic View for SNX33 Gene

Genes around SNX33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX33 Gene

Proteins for SNX33 Gene

  • Protein details for SNX33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV41-SNX33_HUMAN
    Recommended name:
    Sorting nexin-33
    Protein Accession:
    Q8WV41
    Secondary Accessions:
    • B1NM17

    Protein attributes for SNX33 Gene

    Size:
    574 amino acids
    Molecular mass:
    65265 Da
    Quaternary structure:
    • Homodimer (via BAR domain). Interacts with ADAM15. Interacts with FASLG. Interacts (via SH3 domain) with DNM1 and DNM2. Interacts with WASL.

    Three dimensional structures from OCA and Proteopedia for SNX33 Gene

neXtProt entry for SNX33 Gene

Post-translational modifications for SNX33 Gene

Other Protein References for SNX33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNX33 Gene

Domains & Families for SNX33 Gene

Gene Families for SNX33 Gene

Suggested Antigen Peptide Sequences for SNX33 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV41

UniProtKB/Swiss-Prot:

SNX33_HUMAN :
  • The PX and BAR domains mediate association with membranes and are required for membrane tubulation.
  • Belongs to the sorting nexin family.
Domain:
  • The PX and BAR domains mediate association with membranes and are required for membrane tubulation.
  • Contains 1 BAR domain.
  • Contains 1 PX (phox homology) domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX33: view

Function for SNX33 Gene

Molecular function for SNX33 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

Gene Ontology (GO) - Molecular Function for SNX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16374509
GO:0035091 phosphatidylinositol binding IEA,IBA --
GO:0042802 identical protein binding IPI 19487689
genes like me logo Genes that share ontologies with SNX33: view
genes like me logo Genes that share phenotypes with SNX33: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX33 Gene

Localization for SNX33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX33 Gene

Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941). {ECO:0000269 PubMed:18353773, ECO:0000269 PubMed:21048941}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX33 Gene COMPARTMENTS Subcellular localization image for SNX33 gene
Compartment Confidence
cytosol 5
endosome 4
nucleus 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SNX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IBA --
GO:0005829 cytosol IEA,IDA 18353773
GO:0016020 membrane IEA,IDA 18353773
genes like me logo Genes that share ontologies with SNX33: view

Pathways & Interactions for SNX33 Gene

SuperPathways for SNX33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 22718350
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006897 endocytosis IEA,IMP 22718350
GO:0007032 endosome organization IMP 21048941
genes like me logo Genes that share ontologies with SNX33: view

No data available for Pathways by source and SIGNOR curated interactions for SNX33 Gene

Transcripts for SNX33 Gene

mRNA/cDNA for SNX33 Gene

Unigene Clusters for SNX33 Gene

Sorting nexin 33:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX33 Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for SNX33 Gene

GeneLoc Exon Structure for
SNX33
ECgene alternative splicing isoforms for
SNX33

Expression for SNX33 Gene

mRNA expression in normal human tissues for SNX33 Gene

Protein differential expression in normal tissues from HIPED for SNX33 Gene

This gene is overexpressed in Lung (27.5), Gallbladder (12.9), and Pancreas (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX33 Gene



Protein tissue co-expression partners for SNX33 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNX33 Gene:

SNX33

SOURCE GeneReport for Unigene cluster for SNX33 Gene:

Hs.8705

mRNA Expression by UniProt/SwissProt for SNX33 Gene:

Q8WV41-SNX33_HUMAN
Tissue specificity: Detected in heart and pancreas.
genes like me logo Genes that share expression patterns with SNX33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SNX33 Gene

Orthologs for SNX33 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX33 34 35
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia SNX33 34 35
  • 91.24 (n)
dog
(Canis familiaris)
Mammalia SNX33 34 35
  • 90.58 (n)
rat
(Rattus norvegicus)
Mammalia Snx33 34
  • 88.97 (n)
mouse
(Mus musculus)
Mammalia Snx33 34 16 35
  • 88.68 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX33 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX33 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX33 34 35
  • 81.62 (n)
lizard
(Anolis carolinensis)
Reptilia SNX33 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx33 34
  • 70.63 (n)
Str.2090 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.29278 34
zebrafish
(Danio rerio)
Actinopterygii snx33 34 35
  • 71.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta SH3PX1 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lst-4 34 35
  • 45.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for SNX33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX33 Gene

ENSEMBL:
Gene Tree for SNX33 (if available)
TreeFam:
Gene Tree for SNX33 (if available)

Paralogs for SNX33 Gene

Paralogs for SNX33 Gene

(3) SIMAP similar genes for SNX33 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SNX33: view

Variants for SNX33 Gene

Sequence variations from dbSNP and Humsavar for SNX33 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10706187 -- 75,652,013(+) TTCTG(-/T)TTTTT intron-variant
rs111415263 -- 75,652,020(+) TTTTT(C/T)TCTCT intron-variant
rs111488993 -- 75,657,861(+) GGCAA(A/G)GTTAT utr-variant-3-prime
rs111891177 -- 75,656,589(+) GAATC(A/G)GTTCA intron-variant
rs112123403 -- 75,652,084(+) GCTAG(A/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX33 Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV deletion 23290073
esv2749895 CNV deletion 23290073
nsv1116463 OTHER inversion 24896259
nsv527186 CNV loss 19592680

Variation tolerance for SNX33 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX33 Gene

Disorders for SNX33 Gene

Relevant External Links for SNX33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX33

No disorders were found for SNX33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX33 Gene

Publications for SNX33 Gene

  1. A novel sorting nexin modulates endocytic trafficking and alpha- secretase cleavage of the amyloid precursor protein. (PMID: 18353773) Schobel S. … Lichtenthaler S.F. (J. Biol. Chem. 2008) 2 3 4 64
  2. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. (PMID: 16374509) Kaerkkaeinen S. … Saksela K. (EMBO Rep. 2006) 2 3 4 64
  3. SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. (PMID: 22718350) Ma M.P. … Chircop M. (J. Cell. Sci. 2012) 3 4 64
  4. Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33. (PMID: 20964629) Dislich B. … Lichtenthaler S.F. (Biochem. J. 2011) 3 4 64
  5. The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins. (PMID: 21048941) Wang J.T. … Teasdale R.D. (PLoS ONE 2010) 3 4 64

Products for SNX33 Gene

Sources for SNX33 Gene

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