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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SNX33 Gene

protein-coding GIFtS: 46
GCID: GC15P075940

sorting nexin 33

(Previous name: SH3 and PX domain containing 3 )
(Previous symbol: SH3PX3)

Search for SNX33
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sorting Nexin 33¹ ²		SH3 And PX Domain Containing 3¹ ²
SH3PX3¹ ² ³		SH3 And PX Domain-Containing Protein 3² ³
SH3PXD3C¹ ² ³		MGC32065¹
SNX30¹ ² ³		Sorting Nexin-33²

External Ids:	HGNC: 28468¹	Entrez Gene: 257364²	Ensembl: ENSG00000173548⁷	UniProtKB: Q8WV41³

Export aliases for SNX33 gene to outside databases

Previous GC identifers: GC15P073730 GC15P052697

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SNX33 gene promoter:
SRF p53 SRF (504 AA) FOXO3 STAT5A Tal-1beta FOXO3b FOXO3a ITF-2 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNX33 promoter sequence

Search SABiosciences Chromatin IP Primers for SNX33

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX33

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q23

SNX33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX33 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P075940: view genomic region (about GC identifiers)

Start:	75,940,247 bp from pter	End:	75,954,642 bp from pter
Size:	14,396 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SNX33_HUMAN, Q8WV41 (See protein sequence)

Recommended Name: Sorting nexin-33

Size: 574 amino acids; 65265 Da

Subunit: Interacts with ADAM15. Interacts with FASLG

1 PDB 3D structure from and Proteopedia for SNX33:

4AKV (3D)

Explore the universe of human proteins at neXtProt for SNX33: NX_Q8WV41

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WV41

SNX33 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_695003.1

ENSEMBL proteins:

ENSP00000311427 ENSP00000455436

Human Recombinant Protein Products for SNX33:

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	Uscn ELISAs and CLIAs for SNX33

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SNX33 for domains About GeneDecksing

4 InterPro domains/families:

IPR001683 Phox

IPR014536 Snx9

IPR001452 SH3_domain

IPR019497 Sorting_nexin_WASP-bd-dom

Graphical View of Domain Structure for InterPro Entry Q8WV41

ProtoNet protein and cluster: Q8WV41

2 Blocks protein families:

IPB001452 SH3 domain signature

IPB001683 Phox-like

UniProtKB/Swiss-Prot: SNX33_HUMAN, Q8WV41

Similarity: Belongs to the sorting nexin family

Similarity: Contains 1 BAR domain

Similarity: Contains 1 PX (phox homology) domain

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19807924
GO:0035091	phosphatidylinositol binding	IEA	--

SNX33 for ontologies About GeneDecksing

Animal Models:

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miRNA Products:		OriGene 3'-UTR Clone: SNX33 Browse MicroRNA Expression Plasmids
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		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX33 (see all 18):
		hsa-miR-30c hsa-miR-15a hsa-miR-30d hsa-miR-650 hsa-miR-424 hsa-miR-30a hsa-miR-2115 hsa-miR-195

		SwitchGear 3'UTR luciferase reporter plasmid: SNX33 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX33

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SNX33

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/13 Interacting proteins for SNX33 (Q8WV41^{1, 2, 3} ENSP00000311427⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WAS	P42768²^,³, ENSP00000365891⁴	MINT-7218827 MINT-7218778 MINT-7218860 I2D: score=1 STRING: ENSP00000365891
ADAM15	Q13444²^,³, ENSP00000349436⁴	MINT-2792455 MINT-2792950 I2D: score=2 STRING: ENSP00000349436
SNX9	Q9Y5X1²^,³, ENSP00000376024⁴	MINT-7218758 I2D: score=1 STRING: ENSP00000376024
FASLG	P48023¹^,³, ENSP00000356694⁴	EBI-2481535,EBI-495538 I2D: score=1 STRING: ENSP00000356694
PAK2	Q13177³, ENSP00000314067⁴	I2D: score=1 STRING: ENSP00000314067

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007154	cell communication	IEA	--

SNX33 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SNX33
Search CenterWatch for drugs/clinical trials and news about SNX33

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SNX33 gene:

NM_153271.1

Unigene Cluster for SNX33:

Sorting nexin 33

Hs.8705 [show with all ESTs]

Unigene Representative Sequence: EF653821

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000308527(uc002bau.3) ENST00000569152(uc002bav.3)

miRNA Products:		OriGene 3'-UTR Clone: SNX33 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX33
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX33 (see all 18):
		hsa-miR-30c hsa-miR-15a hsa-miR-30d hsa-miR-650 hsa-miR-424 hsa-miR-30a hsa-miR-2115 hsa-miR-195

		SwitchGear 3'UTR luciferase reporter plasmid: SNX33 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK091291.1 AK126563.1 AL833039.1 BC018775.1 EF219141.1 EF653821.1

6 DOTS entries:

DT.95159750 DT.97794405 DT.310553 DT.308197 DT.95165810 DT.96085281

24/70 AceView cDNA sequences (see all 70):

AI302319 CA313051 BU543393 AI570653 BC018775 AI090012 CB529630 BM707224

NM_153271 BU188796 CF131022 AI864266 CF126533 BQ446201 BX505950 BQ025500

BQ945606 AI904525 AL048303 BQ010405 BF448592 BQ936370 AI344358 CO402330

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SNX33 About this scheme

ExUns:	1a	·	1b	^	2	^	3
SP1:
SP2:

ECgene alternative splicing isoforms for SNX33

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SNX33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCTCCTCCT

About this image

SNX33 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SNX33 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX33

SOURCE GeneReport for Unigene cluster: Hs.8705

SABiosciences Custom PCR Arrays for SNX33

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX33 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX33

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SNX33 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SNX33¹	sorting nexin 33	81.62(n) 84.31(a)		415309 XM_003641813.1 XP_003641861.1
lizard (Anolis carolinensis)	Reptilia	SNX33⁶	--	83(a)	1 ↔ 1	GL343374.1(29127-44936)
African clawed frog (Xenopus laevis)	Amphibia	Xl.29278²	Xenopus laevis transcribed sequence with weak similarity more	78.09(n)		BJ075402.1
zebrafish (Danio rerio)	Actinopterygii	snx33¹	sorting nexin 33	72.06(n) 77.82(a)		100001421 NM_001122855.2 NP_001116327.1
fruit fly (Drosophila melanogaster)	Insecta	SH3PX1⁶	SH3PX1	32(a)	1 → many	3L(9703522-9706927)
worm (Caenorhabditis elegans)	Secernentea	lst-4⁶	Lateral Signaling Target family member (lst-4)	29(a)	1 → many	IV(14060980-14069831)

ENSEMBL Gene Tree for SNX33 (if available)
TreeFam Gene Tree for SNX33 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SNX33 gene

SNX9² SNX18²

3 SIMAP similar genes for SNX33 using alignment to 4 protein entries: SNX33_HUMAN (see all proteins):

SH3GL2 SNX18 SNX9

SNX33 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SNX33
PGOHUM00000234190

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74026520^1,2	C,F	--	75939386(+)	`CAACAC/TGGAAC`	1	--	us2k¹		3		WA CSA	122
rs74841574^1,2	F	--	75939428(+)	`GCAGAT/GGTAGA`	1	--	us2k¹		1		WA	118
rs116541320^1,2	F	--	75939642(+)	`GAGTCC/AGCGAC`	1	--	us2k¹		1		WA	118
rs117175491^1,2	F	--	75940054(+)	`CGGAGG/TAGTAG`	1	--	us2k¹		1		EA	120
rs73439279^1,2	C,F	--	75940274(+)	`GCTGCC/TTTCTC`	1	--	us2k¹		1		WA	118
rs186572469^1,2		--	75940431(+)	`AAACTA/CCAAAC`	1	--	us2k¹		0	--	--	--	--
rs137901927^1,2		--	75940465(+)	`AGGGTG/TGTGAT`	1	--	us2k¹		0	--	--	--	--
rs78696025^1,2	F	--	75940547(+)	`AGAGCA/CGGGTC`	1	--	us2k¹		1		EA	120
rs12438973^1,2	C,H	--	75940589(+)	`GGCAAA/CCAAAA`	1	--	us2k¹		1		NA	2
rs79091092^1,2	F	--	75940664(+)	`GGTTGG/AGGCTG`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for SNX33 (75940247 - 75954642 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SNX33
1 CNV: 77008

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX33

DNA2.0 Custom Variant and Variant Library Synthesis for SNX33

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SNX33 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with SNX33)

Utopia: connect your pdf to the dynamic
world of online information

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. (PubMed id 16374509)^{1, 2, 3} Kaerkkaeinen S.... Saksela K. (2006)
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)^{1, 2} Voss M....Janssen O. (2009)
Alternative splicing of ADAM15 regulates its interact ions with cellular SH3 proteins. (PubMed id 19718658)^{1, 2} Kleino I....Saksela K. (2009)
A novel sorting nexin modulates endocytic trafficking and alpha- secretase cleavage of the amyloid precursor protein. (PubMed id 18353773)^{1, 3} Schobel S.... Lichtenthaler S.F. (2008)
The Phox (PX) domain proteins and membrane traffic. (PubMed id 16782399)^{1, 3} Seet L.F. and Hong W. (2006)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Specific amino acids in the BAR domain allow homodime rization and prevent heterodimerization of sorting nexin 33. (PubMed id 20964629)¹ Dislich B....Lichtenthaler S.F. (2011)
Sorting nexin 33 induces mammalian cell micronucleate d phenotype and actin polymerization by interacting with Wiskott-Aldrich syndro me protein. (PubMed id 19487689)¹ Zhang J....Pei D. (2009)
The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding. (PubMed id 18419754)¹ Heiseke A....Nunziante M. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 257364	HGNC: 28468	AceView: MGC32065	Ensembl:ENSG00000173548	euGenes: HUgn257364
ECgene: SNX33	H-InvDB: SNX33

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SNX33	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SNX33 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SNX33 gene:
Search GeneIP for patents involving SNX33

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX33
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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