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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SNX32 Gene

protein-coding GIFtS: 45
GCID: GC11P065601

sorting nexin 32

(Previous name: sorting nexin 6B )
(Previous symbol: SNX6B)

Search for SNX32
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sorting Nexin 32¹ ²
SNX6B¹ ² ³
Sorting Nexin 6B¹ ²
Sorting Nexin-6B² ³
FLJ30934¹
Sorting Nexin-32²

External Ids:	HGNC: 26423¹	Entrez Gene: 254122²	Ensembl: ENSG00000172803⁷	UniProtKB: Q86XE0³

Export aliases for SNX32 gene to outside databases

Previous GC identifers: GC11P065357 GC11P061927

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SNX32_HUMAN, Q86XE0

Function: May be involved in several stages of intracellular trafficking (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SNX32 gene promoter:
NF-E2 p45 Gfi-1 RORalpha1 N-Myc GATA-6 POU2F1 POU2F1a NF-E2 Pax-4a ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNX32 promoter sequence

Search SABiosciences Chromatin IP Primers for SNX32

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX32

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1

SNX32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX32 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P065601: view genomic region (about GC identifiers)

Start:	65,601,112 bp from pter	End:	65,624,367 bp from pter
Size:	23,256 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SNX32_HUMAN, Q86XE0 (See protein sequence)

Recommended Name: Sorting nexin-32

Size: 403 amino acids; 46399 Da

Secondary accessions: Q8IW53 Q96NG4

Alternative splicing: 2 isoforms: Q86XE0-1 Q86XE0-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SNX32: NX_Q86XE0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86XE0

SNX32 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689973.2

ENSEMBL proteins:

ENSP00000310620

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SNX32 for domains About GeneDecksing

3 InterPro domains/families:

IPR001683 Phox

IPR015404 Vps5_C

IPR014637 Snx5_Snx6

Graphical View of Domain Structure for InterPro Entry Q86XE0

ProtoNet protein and cluster: Q86XE0

1 Blocks protein family: IPB001683 Phox-like

UniProtKB/Swiss-Prot: SNX32_HUMAN, Q86XE0

Similarity: Belongs to the sorting nexin family

Similarity: Contains 1 PX (phox homology) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SNX32_HUMAN, Q86XE0

Function: May be involved in several stages of intracellular trafficking (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0035091	phosphatidylinositol binding	IEA	--

SNX32 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX32

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SNX32

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for SNX32 (Q86XE0³ ENSP00000310620⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SNX1	Q13596³, ENSP00000369638⁴	I2D: score=1 STRING: ENSP00000369638
SNX2	ENSP00000368831⁴	STRING: ENSP00000368831
VPS29	ENSP00000380795⁴	STRING: ENSP00000380795
VPS35	ENSP00000299138⁴	STRING: ENSP00000299138

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007154	cell communication	IEA	--
GO:0015031	protein transport	IEA	--

SNX32 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SNX32
Search CenterWatch for drugs/clinical trials and news about SNX32

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SNX32 gene:

NM_152760.2

Unigene Cluster for SNX32:

Sorting nexin 32

Hs.591950 [show with all ESTs]

Unigene Representative Sequence: AL833261

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000308342(uc001ofr.3) ENST00000533298(uc010rop.1) ENST00000531503(uc009yqt.3)

ENST00000531795 ENST00000526972 ENST00000534387 ENST00000524729 ENST00000530101

ENST00000533236

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		hsa-miR-146b-3p hsa-miR-548aa
		SwitchGear 3'UTR luciferase reporter plasmid: SNX32 3' UTR sequence

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Additional cDNA sequence:

AK289587.1 AK293827.1 AK296055.1 AK299512.1 AK309435.1 AK309789.1 AK311588.1 AL833261.1

BC040981.2 BC045563.1

9 DOTS entries:

DT.100045768 DT.95361135 DT.102839914 DT.120690027 DT.120690192 DT.100882412 DT.40208580 DT.425826

DT.91974206

24/124 AceView cDNA sequences (see all 124):

AW451684 BE219367 BI754340 AL833261 BF933256 W67154 BE464787 BF724391

BF759385 AW067784 AA351390 BI022376 CD638068 BF801710 BI754354 M78086

AA134467 CA312235 BI063904 AA837810 AA434171 CD638072 AW340085 BM921257

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SNX32 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14
SP1:											-						-		-								-
SP2:											-						-		-								-
SP3:											-						-		-
SP4:											-				-		-		-
SP5:									-		-						-		-

ECgene alternative splicing isoforms for SNX32

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SNX32 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCATCATAA

About this image

SNX32 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SNX32 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX32

SOURCE GeneReport for Unigene cluster: Hs.591950

SABiosciences Custom PCR Arrays for SNX32

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX32

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SNX32 gene from 2/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
fruit fly (Drosophila melanogaster)	Insecta	Snx6⁶	Snx6	47(a)	possible ortholog	2L(8218071-8220741)
worm (Caenorhabditis elegans)	Secernentea	snx-6¹	Protein SNX-6	55.74(n) 53.22(a)		190399 NM_075117.7 NP_507518.4

ENSEMBL Gene Tree for SNX32 (if available)
TreeFam Gene Tree for SNX32 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SNX32 gene

SNX6² SNX2² SNX1² SNX5²

2 SIMAP similar genes for SNX32 using alignment to 1 protein entry: SNX32_HUMAN:

SNX6 SNX5

SNX32 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs180963530^1,2		--	65599415(+)	`AAACAA/GATTCA`	1	--	us2k¹		0	--	--	--	--
rs11227320^1,2	F	--	65599432(+)	`ATATCT/CTTCAC`	1	--	us2k¹		1		EA	120
rs76756050^1,2	F	--	65599538(+)	`CATGAG/ATAAAT`	1	--	us2k¹		1		NA	120
rs186152808^1,2		--	65599636(+)	`TCCCCA/GCTGGT`	1	--	us2k¹		0	--	--	--	--
rs77779142^1,2	C,F	--	65599656(+)	`CTCCTC/TACTAG`	1	--	us2k¹		3		WA NA EA	358
rs75955411^1,2		--	65599676(+)	`TCTCCG/ACACTT`	1	--	us2k¹		2		CSA WA	120
rs115500767^1,2	F	--	65599677(+)	`CTCCGC/TACTTG`	1	--	us2k¹		1		WA	118
rs7110385^1,2	C,H	--	65599743(+)	`TCCACT/CGGTTC`	1	--	us2k¹		4		NS EA	404
rs79879340^1,2	C	--	65599744(+)	`CCACTA/GGTTCC`	1	--	us2k¹		0	--	--	--	--
rs147438373^1,2	C	--	65600058(+)	`TCCAC-/TCAACCTCA GCTTCTCTCTGATTGAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SNX32 (65601112 - 65624367 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SNX32
1 CNV: 3855

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX32

DNA2.0 Custom Variant and Variant Library Synthesis for SNX32

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SNX32 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SNX32)

Utopia: connect your pdf to the dynamic
world of online information

The Phox (PX) domain proteins and membrane traffic. (PubMed id 16782399)^{1, 3} Seet L.F. and Hong W. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)¹ Fu G.K....Stuve L.L. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 254122	HGNC: 26423	AceView: FLJ30934	Ensembl:ENSG00000172803	euGenes: HUgn254122
ECgene: SNX32	H-InvDB: SNX32

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SNX32	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SNX32 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SNX32 gene:
Search GeneIP for patents involving SNX32

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX32		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX32
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for SNX32		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SNX32		OriGene Custom Protein Services for SNX32
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX32
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX32
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	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX32
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	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX32

	GenScript Custom Purified and Recombinant Proteins Services for SNX32		GenScript cDNA clones with any tag delivered in your preferred vector for SNX32
	GenScript Custom Assay Services for SNX32		GenScript Custom Superior Antibodies Services for SNX32
	GenScript Custom overexpressing Cell Line Services for SNX32		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in SNX32 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX32

	SwitchGear 3'UTR luciferase reporter plasmids for SNX32
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Search ThermoFisher Antibodies for SNX32

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX32

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SNX32

Sirion Biotech Customized:

	stable knockdown cell line services for SNX32
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	adenovirus for potent knockdown of SNX32
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	stable overexpressing cell line services for SNX32
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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