SNX31 Gene
protein-coding GIFtS: 44
GCID: GC08M101585
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sorting nexin 31
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Aliases for SNX31 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Sorting Nexin 311 2 | | MGC397151 | | Sorting Nexin-312 |
Export aliases for SNX31 gene to outside databasesPrevious GC identifers: GC08M101656 GC08M096784 |
Summaries for SNX31 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SNX31_HUMAN, Q8N9S9Function: May be involved in protein trafficking (By similarity)
|
Genomic Views for SNX31 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SNX31 gene promoter: AP-2gamma Max AREB6 HEN1 POU2F1 POU2F1a AP-2beta AP-2alpha c-Myc AP-2alphaA Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX31
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX31 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q22.3 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22.3SNX31 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M101585: view genomic region
(about GC identifiers)
Start:
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101,585,110 bp from pter |
End:
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101,675,643 bp from pter |
Size:
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90,534 bases |
Orientation:
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minus strand |
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Proteins for SNX31 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SNX31_HUMAN, Q8N9S9 (See
protein sequence)Recommended Name: Sorting nexin-31 Size: 440 amino acids; 50802 Da
Secondary accessions: C9J6L9 Q8N0U9Alternative splicing: 2 isoforms: Q8N9S9-1 Q8N9S9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SNX31: NX_Q8N9S9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N9S9 SNX31 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689841.3 ENSEMBL proteins: ENSP00000312368 ENSP00000429110 ENSP00000405024 ENSP00000428210 ENSP00000428855 ENSP00000428262 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005856 | cytoskeleton |
-- | -- |
SNX31 for ontologies About GeneDecksing
SNX31 Antibody Products: Assay Products for SNX31: |
Protein
Domains / Families for SNX31 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX31 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N9S9ProtoNet protein and cluster: Q8N9S9 1 Blocks protein family: IPB001683 Phox-like
UniProtKB/Swiss-Prot: SNX31_HUMAN, Q8N9S9Similarity: Belongs to the sorting nexin familySimilarity: Contains 1 PX (phox homology) domain |
Function for SNX31 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SNX31_HUMAN, Q8N9S9Function: May be involved in protein trafficking (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX31 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX31 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SNX31 (NM_152628) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX31 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX31  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX31 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035091 | phosphatidylinositol binding |
IEA | -- |
SNX31 for ontologies About GeneDecksing
|
Pathways & Interactions for SNX31 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX31
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007154 | cell communication |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- |
SNX31 for ontologies About GeneDecksing
|
Drugs & Compounds for SNX31 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SNX31 Search CenterWatch for drugs/clinical trials and news about SNX31 
|
Transcripts for SNX31 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SNX31 gene: NM_152628.3 Unigene Cluster for SNX31: Sorting nexin 31 Hs.567758 [show with all ESTs]Unigene Representative Sequence: AK1275177 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000311812(uc011lha.2 uc011lhb.2 uc003yjr.3) ENST00000518342 ENST00000428383 ENST00000519521 ENST00000520352 ENST00000520661 ENST00000520743
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX31 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX31 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SNX31 (NM_152628) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX31 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX31  |
Additional cDNA sequence: AK093906.1 AK127517.1 BC031260.1 5 DOTS entries: DT.91721140 DT.101968391 DT.97835155 DT.65287690 DT.99988311 24/26 AceView cDNA sequences (see all 26): BX283791 CD106024 BQ012274 BC031260 AX748361 D81739 BQ013261 N95691 NM_152628 BX483398 AK093906 BQ013671 N63402 BI461122 AI867804 AI611654 AK127517 BX094666 CD637915 N48580 N47267 AW630535 BF029081 BF029450 GeneLoc Exon Structure
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Expression for SNX31 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX31 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CTATTTGGAA
About this image See SNX31 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SNX31
SOURCE GeneReport for Unigene cluster: Hs.567758 SABiosciences Custom PCR Arrays for SNX31
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX31 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX31 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX31 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX31 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX31 |
Orthologs for SNX31 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNX31 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for SNX31 (if available) TreeFam Gene Tree for SNX31 (if available)  |
Paralogs for SNX31 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SNX31 gene
- SNX272 SNX172
18/34 SIMAP similar genes for SNX31 using alignment to 5 protein entries: SNX31_HUMAN (see all proteins)
(see all similar genes):LYRM4 NF2 ZNF585B ZDHHC20 FAM210A CHID1 NSRP1 FAM3A PLEKHH2 ZNF212 RNF217 ZNF461 UTY DCTN5 GCDH ZNF564 FKBP3 SNX17
SNX31 for paralogs About GeneDecksing
|
Genomic Variants for SNX31 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 8 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX31 (101585110 - 101675643 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for SNX31 1 Indel: 10845  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX31 |
|
Disorders
/ Diseases for SNX31 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNX31 for disorders About GeneDecksing
2 diseases for SNX31: About MalaCardssystemic lupus erythematosus lupus erythematosus Human Genome Epidemiology (HuGE) Navigator: SNX31 (1 document) Export disorders for SNX31 gene to outside databases
|
Publications for SNX31 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX31 gene integrated from 9 sources: (articles sorted by number of sources associating them with SNX31) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The Phox (PX) domain proteins and membrane traffic. (PubMed id 16782399)1, 3 Seet L.F. and Hong W. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Lack of deleterious somatic mutations in the CD95 gene of plasmablasts from systemic lupus erythematosus patients and autoantibody-producing cell lines. (PubMed id 12516573)1 Kurth J.... Kuppers R. (2002)
|
External Searches for SNX31 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SNX31 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX31 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNX31 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SNX31 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX31 gene: Search GeneIP for patents involving SNX31
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SNX31 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for SNX31 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX31 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX31 | | OriGene Protein Over-expression Lysate for SNX31 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for SNX31 | | OriGene 3'-UTR Clone for SNX31 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX31 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX31 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for SNX31 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for SNX31 | | OriGene Custom Protein Services for SNX31 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX31 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX31 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX31 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX31 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX31 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX31 |
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| | | Search Tocris compounds for SNX31 |
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 | | SNX31 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX31 |
|  |  |  | | | ThermoFisher Antibodies for SNX31 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX31 |
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