Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SNX31 Gene

Aliases for SNX31 Gene

  • Sorting Nexin 31 2 3 5

External Ids for SNX31 Gene

Previous GeneCards Identifiers for SNX31 Gene

  • GC08M101656
  • GC08M101585
  • GC08M096784

Summaries for SNX31 Gene

GeneCards Summary for SNX31 Gene

SNX31 (Sorting Nexin 31) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX17.

UniProtKB/Swiss-Prot for SNX31 Gene

  • May be involved in protein trafficking.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX31 Gene

Genomics for SNX31 Gene

Regulatory Elements for SNX31 Gene

Enhancers for SNX31 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNX31 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX31 Gene

100,572,882 bp from pter
100,663,415 bp from pter
90,534 bases
Minus strand

Genomic View for SNX31 Gene

Genes around SNX31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX31 Gene

Proteins for SNX31 Gene

  • Protein details for SNX31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-31
    Protein Accession:
    Secondary Accessions:
    • C9J6L9
    • Q8N0U9

    Protein attributes for SNX31 Gene

    440 amino acids
    Molecular mass:
    50802 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SNX31 Gene


neXtProt entry for SNX31 Gene

Proteomics data for SNX31 Gene at MOPED

Post-translational modifications for SNX31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX31 Gene

No data available for DME Specific Peptides for SNX31 Gene

Domains & Families for SNX31 Gene

Gene Families for SNX31 Gene

Protein Domains for SNX31 Gene


Suggested Antigen Peptide Sequences for SNX31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PX (phox homology) domain.
  • Belongs to the sorting nexin family.
  • Contains 1 PX (phox homology) domain.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX31: view

Function for SNX31 Gene

Molecular function for SNX31 Gene

UniProtKB/Swiss-Prot Function:
May be involved in protein trafficking.
genes like me logo Genes that share phenotypes with SNX31: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNX31 Gene

Localization for SNX31 Gene

Subcellular locations from

Jensen Localization Image for SNX31 Gene COMPARTMENTS Subcellular localization image for SNX31 gene
Compartment Confidence
endosome 4
cytosol 3
nucleus 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SNX31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IBA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with SNX31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SNX31 Gene

Pathways & Interactions for SNX31 Gene

SuperPathways for SNX31 Gene

No Data Available

Interacting Proteins for SNX31 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000312368 Q8N9S9-SNX31_HUMAN for SNX31 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SNX31 Gene


No data available for Pathways by source and SIGNOR curated interactions for SNX31 Gene

Drugs & Compounds for SNX31 Gene

No Compound Related Data Available

Transcripts for SNX31 Gene

Unigene Clusters for SNX31 Gene

Sorting nexin 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX31 Gene

No ASD Table

Relevant External Links for SNX31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX31 Gene

mRNA expression in normal human tissues for SNX31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNX31 Gene

This gene is overexpressed in Bladder (x24.4) and Esophagus - Mucosa (x5.6).

Protein differential expression in normal tissues from HIPED for SNX31 Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNX31 Gene

SOURCE GeneReport for Unigene cluster for SNX31 Gene Hs.567758

genes like me logo Genes that share expression patterns with SNX31: view

Protein tissue co-expression partners for SNX31 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SNX31 Gene

Orthologs for SNX31 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SNX31 35
  • 88.13 (n)
  • 84.25 (a)
SNX31 36
  • 85 (a)
(Canis familiaris)
Mammalia SNX31 35
  • 87.95 (n)
  • 83.3 (a)
SNX31 36
  • 81 (a)
(Mus musculus)
Mammalia Snx31 35
  • 80.37 (n)
  • 75.8 (a)
Snx31 16
Snx31 36
  • 75 (a)
(Pan troglodytes)
Mammalia SNX31 35
  • 99.47 (n)
  • 99.32 (a)
SNX31 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Snx31 35
  • 80.33 (n)
  • 74.26 (a)
(Monodelphis domestica)
Mammalia SNX31 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia SNX31 36
  • 74 (a)
(Anolis carolinensis)
Reptilia SNX31 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx31 35
  • 57.01 (n)
  • 45.33 (a)
Str.20203 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3842 35
(Danio rerio)
Actinopterygii snx27b 36
  • 16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5734 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea snx-17 36
  • 18 (a)
Species with no ortholog for SNX31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX31 Gene

Gene Tree for SNX31 (if available)
Gene Tree for SNX31 (if available)

Paralogs for SNX31 Gene

Paralogs for SNX31 Gene

genes like me logo Genes that share paralogs with SNX31: view

Variants for SNX31 Gene

Sequence variations from dbSNP and Humsavar for SNX31 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2187016 - 100,635,936(-) TGGCT(C/G)ATGAG reference, missense
rs2248609 - 100,596,691(-) GACCC(A/G)GGACA intron-variant, reference, missense
rs2022923 - 100,573,905(-) TAAAG(A/G)TGACT reference, missense
rs2096548 -- 100,598,972(-) aatta(A/G)cttaa intron-variant
rs2154639 -- 100,578,242(-) TCCCC(A/C)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX31 Gene

Variant ID Type Subtype PubMed ID
nsv527071 CNV Loss 19592680
esv2678325 CNV Deletion 23128226
esv2659653 CNV Deletion 23128226
nsv438073 CNV Loss 16468122

Variation tolerance for SNX31 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.22; 96.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX31 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX31 Gene

Disorders for SNX31 Gene

Relevant External Links for SNX31

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SNX31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX31 Gene

Publications for SNX31 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The Phox (PX) domain proteins and membrane traffic. (PMID: 16782399) Seet L.F. … Hong W. (Biochim. Biophys. Acta 2006) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A. … Verhasselt B. (Retrovirology 2014) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SNX31 Gene

Sources for SNX31 Gene