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Aliases for SNX30 Gene

Aliases for SNX30 Gene

  • Sorting Nexin Family Member 30 2 3 5
  • ATG24A 3

External Ids for SNX30 Gene

Previous GeneCards Identifiers for SNX30 Gene

  • GC09P112594
  • GC09P114519
  • GC09P115513
  • GC09P085110

Summaries for SNX30 Gene

GeneCards Summary for SNX30 Gene

SNX30 (Sorting Nexin Family Member 30) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX4.

UniProtKB/Swiss-Prot for SNX30 Gene

  • May be involved in several stages of intracellular trafficking.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX30 Gene

Genomics for SNX30 Gene

Regulatory Elements for SNX30 Gene

Promoters for SNX30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNX30 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX30 Gene

Chromosome:
9
Start:
112,749,725 bp from pter
End:
112,881,671 bp from pter
Size:
131,947 bases
Orientation:
Plus strand

Genomic View for SNX30 Gene

Genes around SNX30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX30 Gene

Proteins for SNX30 Gene

  • Protein details for SNX30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWJ9-SNX30_HUMAN
    Recommended name:
    Sorting nexin-30
    Protein Accession:
    Q5VWJ9

    Protein attributes for SNX30 Gene

    Size:
    437 amino acids
    Molecular mass:
    49677 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNX30 Gene

Proteomics data for SNX30 Gene at MOPED

Post-translational modifications for SNX30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX30 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNX30 Gene

Domains & Families for SNX30 Gene

Gene Families for SNX30 Gene

Protein Domains for SNX30 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX30 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VWJ9

UniProtKB/Swiss-Prot:

SNX30_HUMAN :
  • Contains 1 PX (phox homology) domain.
  • Belongs to the sorting nexin family.
Domain:
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX30: view

Function for SNX30 Gene

Molecular function for SNX30 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking.

Gene Ontology (GO) - Molecular Function for SNX30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035091 phosphatidylinositol binding IEA,IBA --
genes like me logo Genes that share ontologies with SNX30: view
genes like me logo Genes that share phenotypes with SNX30: view

Animal Model Products

miRNA for SNX30 Gene

miRTarBase miRNAs that target SNX30

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX30 Gene

Localization for SNX30 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX30 Gene COMPARTMENTS Subcellular localization image for SNX30 gene
Compartment Confidence
cytosol 4
endosome 3
nucleus 3

Gene Ontology (GO) - Cellular Components for SNX30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
genes like me logo Genes that share ontologies with SNX30: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SNX30 Gene

Pathways & Interactions for SNX30 Gene

SuperPathways for SNX30 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016050 vesicle organization IBA --
genes like me logo Genes that share ontologies with SNX30: view

No data available for Pathways by source and SIGNOR curated interactions for SNX30 Gene

Drugs & Compounds for SNX30 Gene

No Compound Related Data Available

Transcripts for SNX30 Gene

Unigene Clusters for SNX30 Gene

Sorting nexin family member 30:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX30 Gene

No ASD Table

Relevant External Links for SNX30 Gene

GeneLoc Exon Structure for
SNX30
ECgene alternative splicing isoforms for
SNX30

Expression for SNX30 Gene

mRNA expression in normal human tissues for SNX30 Gene

Protein differential expression in normal tissues from HIPED for SNX30 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.1), Saliva (6.9), Frontal cortex (6.7), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX30 Gene



SOURCE GeneReport for Unigene cluster for SNX30 Gene Hs.522350

genes like me logo Genes that share expression patterns with SNX30: view

Protein tissue co-expression partners for SNX30 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX30 Gene

Orthologs for SNX30 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX30 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNX30 35
  • 91 (n)
  • 95.88 (a)
SNX30 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX30 35
  • 92.03 (n)
  • 97.92 (a)
SNX30 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx30 35
  • 90.31 (n)
  • 95.42 (a)
Snx30 16
Snx30 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNX30 35
  • 98.63 (n)
  • 98.63 (a)
SNX30 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx30 35
  • 90.62 (n)
  • 96.8 (a)
oppossum
(Monodelphis domestica)
Mammalia SNX30 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX30 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX30 35
  • 77.73 (n)
  • 87.79 (a)
SNX30 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX30 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx30 35
  • 73.78 (n)
  • 81.65 (a)
zebrafish
(Danio rerio)
Actinopterygii snx30 35
  • 70.76 (n)
  • 78.96 (a)
snx30 36
  • 78 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR074W 35
  • 46.63 (n)
  • 31.12 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10967g 35
  • 42.89 (n)
  • 28.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX4 35
  • 43.91 (n)
  • 30.21 (a)
SNX4 36
  • 22 (a)
OneToMany
SNX4 38
bread mold
(Neurospora crassa)
Ascomycetes NCU03218 35
  • 43.13 (n)
  • 29.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC6F6.12 35
  • 42.94 (n)
  • 28.82 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9288 36
  • 37 (a)
OneToMany
Species with no ortholog for SNX30:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX30 Gene

ENSEMBL:
Gene Tree for SNX30 (if available)
TreeFam:
Gene Tree for SNX30 (if available)

Paralogs for SNX30 Gene

Paralogs for SNX30 Gene

(4) SIMAP similar genes for SNX30 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNX30: view

Variants for SNX30 Gene

Sequence variations from dbSNP and Humsavar for SNX30 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2796036 - 112,749,765(-) CAGAT(C/G)TTGAC upstream-variant-2KB, utr-variant-5-prime
rs10117709 - 112,817,728(+) GACCT(C/G)CCAGA reference, synonymous-codon
rs700122 -- 112,789,567(+) AGTAT(A/G)TGCTT intron-variant
rs715667 -- 112,768,284(-) ACATC(A/G)AGAGG intron-variant
rs957681 -- 112,786,885(+) GTTTA(A/G)AATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX30 Gene

Variant ID Type Subtype PubMed ID
dgv2411e1 CNV Complex 17122850
dgv2412e1 CNV Complex 17122850
nsv515899 CNV Gain+Loss 19592680
dgv262e55 CNV Gain 17911159
dgv2413e1 CNV Complex 17122850
nsv471317 CNV Gain 18288195
nsv515121 CNV Gain 21397061
nsv442163 CNV CNV 18776908
nsv893733 CNV Gain 21882294
nsv8559 CNV Gain 18304495
esv2422302 CNV Deletion 17116639
essv15169 CNV CNV 17122850
nsv8560 CNV Loss 18304495
nsv825049 CNV Gain 20364138
esv995366 CNV Loss 20482838
esv1549334 CNV Insertion 17803354

Variation tolerance for SNX30 Gene

Residual Variation Intolerance Score: 53.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX30 Gene

HapMap Linkage Disequilibrium report
SNX30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX30 Gene

Disorders for SNX30 Gene

Relevant External Links for SNX30

Genetic Association Database (GAD)
SNX30
Human Genome Epidemiology (HuGE) Navigator
SNX30
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX30

No disorders were found for SNX30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX30 Gene

Publications for SNX30 Gene

  1. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A. … Vieira A.R. (Am. J. Med. Genet. A 2010) 3 48 67
  2. Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. (PMID: 22745667) Asbach B. … Wagner R. (PLoS ONE 2012) 3
  3. Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. (PMID: 23085988) van Weering J.R. … Cullen P.J. (EMBO J. 2012) 3
  4. SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1- positive endosomal trafficking. (PMID: 18411244) Haberg K. … Carlsson S.R. (J. Cell Sci. 2008) 23
  5. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. (PMID: 16374509) Kaerkkaeinen S. … Saksela K. (EMBO Rep. 2006) 3

Products for SNX30 Gene

Sources for SNX30 Gene

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