Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SNX30 Gene

Aliases for SNX30 Gene

  • Sorting Nexin Family Member 30 2 3 5
  • Sorting Nexin-30 3
  • ATG24A 3

External Ids for SNX30 Gene

Previous GeneCards Identifiers for SNX30 Gene

  • GC09P112594
  • GC09P114519
  • GC09P115513
  • GC09P085110

Summaries for SNX30 Gene

GeneCards Summary for SNX30 Gene

SNX30 (Sorting Nexin Family Member 30) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX7.

UniProtKB/Swiss-Prot for SNX30 Gene

  • May be involved in several stages of intracellular trafficking.

Additional gene information for SNX30 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX30 Gene

Genomics for SNX30 Gene

Regulatory Elements for SNX30 Gene

Enhancers for SNX30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H112860 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +112.9 112891 4 CEBPB ZMYM3 MAX GABPA POLR2A EGR1 EED KDM1A RUNX3 PRDM1 SLC46A2 SNX30 ENSG00000226609 SLC31A2 ENSG00000271631 FKBP15 PIR49803
GH09H112783 1.1 Ensembl ENCODE 18.9 +34.3 34278 1 NFIB ZBTB21 INSM2 ZNF2 RFX5 ZNF324 CTBP1 GATA3 ZNF316 POLR2A SNX30 ENSG00000226609 INIP SLC46A2 PIR49803
GH09H112844 1.4 Ensembl ENCODE dbSUPER 14.6 +95.3 95340 0 ARNT ARID4B ZBTB40 ZSCAN9 RAD21 CHAMP1 RFX5 YY1 ETS1 ELK1 ENSG00000226609 SNX30 SLC46A2 PIR49803
GH09H112866 1.4 Ensembl ENCODE dbSUPER 9.8 +118.7 118698 4 HDGF PKNOX1 FOXA2 ARNT ARID4B NFXL1 EGR1 FOS EGR2 SP3 SLC46A2 ENSG00000226609 SNX30 SLC31A2 INIP PIR49803
GH09H112893 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.5 +144.9 144926 1 BATF MYC MAFK SNX30 SLC46A2 SLC31A2 FKBP15 MUPP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNX30 on UCSC Golden Path with GeneCards custom track

Promoters for SNX30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000240004 1275 1601 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 SP5 MXD4

Genomic Location for SNX30 Gene

Chromosome:
9
Start:
112,749,725 bp from pter
End:
112,881,671 bp from pter
Size:
131,947 bases
Orientation:
Plus strand

Genomic View for SNX30 Gene

Genes around SNX30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX30 Gene

Proteins for SNX30 Gene

  • Protein details for SNX30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWJ9-SNX30_HUMAN
    Recommended name:
    Sorting nexin-30
    Protein Accession:
    Q5VWJ9

    Protein attributes for SNX30 Gene

    Size:
    437 amino acids
    Molecular mass:
    49677 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNX30 Gene

Post-translational modifications for SNX30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX30 Gene

No data available for DME Specific Peptides for SNX30 Gene

Domains & Families for SNX30 Gene

Gene Families for SNX30 Gene

Protein Domains for SNX30 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX30 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VWJ9

UniProtKB/Swiss-Prot:

SNX30_HUMAN :
  • Belongs to the sorting nexin family.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX30: view

Function for SNX30 Gene

Molecular function for SNX30 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking.

Phenotypes From GWAS Catalog for SNX30 Gene

Gene Ontology (GO) - Molecular Function for SNX30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23085988
GO:0035091 phosphatidylinositol binding IBA --
genes like me logo Genes that share ontologies with SNX30: view
genes like me logo Genes that share phenotypes with SNX30: view

Animal Model Products

CRISPR Products

miRNA for SNX30 Gene

miRTarBase miRNAs that target SNX30

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SNX30
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX30 Gene

Localization for SNX30 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX30 gene
Compartment Confidence
cytosol 4
nucleus 3
endosome 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNX30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IBA --
GO:0019898 extrinsic component of membrane IBA --
genes like me logo Genes that share ontologies with SNX30: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SNX30 Gene

Pathways & Interactions for SNX30 Gene

SuperPathways for SNX30 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006897 endocytosis IBA --
GO:0015031 protein transport IEA --
GO:0016050 vesicle organization IBA --
genes like me logo Genes that share ontologies with SNX30: view

No data available for Pathways by source and SIGNOR curated interactions for SNX30 Gene

Drugs & Compounds for SNX30 Gene

No Compound Related Data Available

Transcripts for SNX30 Gene

Unigene Clusters for SNX30 Gene

Sorting nexin family member 30:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SNX30
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SNX30 Gene

No ASD Table

Relevant External Links for SNX30 Gene

GeneLoc Exon Structure for
SNX30
ECgene alternative splicing isoforms for
SNX30

Expression for SNX30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX30 Gene

Protein differential expression in normal tissues from HIPED for SNX30 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.1), Saliva (6.9), Frontal cortex (6.7), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX30 Gene



Protein tissue co-expression partners for SNX30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNX30 Gene:

SNX30

SOURCE GeneReport for Unigene cluster for SNX30 Gene:

Hs.522350

Evidence on tissue expression from TISSUES for SNX30 Gene

  • Liver(4.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with SNX30: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX30 Gene

Orthologs for SNX30 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX30 34 33
  • 98.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SNX30 33 34
  • 92.03 (n)
cow
(Bos Taurus)
Mammalia SNX30 33 34
  • 91 (n)
rat
(Rattus norvegicus)
Mammalia Snx30 33
  • 90.62 (n)
mouse
(Mus musculus)
Mammalia Snx30 16 34 33
  • 90.31 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX30 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX30 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX30 33 34
  • 77.73 (n)
lizard
(Anolis carolinensis)
Reptilia SNX30 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx30 33
  • 73.78 (n)
zebrafish
(Danio rerio)
Actinopterygii snx30 33 34
  • 70.76 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR074W 33
  • 46.63 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX4 33 34 36
  • 43.91 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10967g 33
  • 42.89 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03218 33
  • 43.13 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC6F6.12 33
  • 42.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9288 34
  • 37 (a)
OneToMany
Species where no ortholog for SNX30 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX30 Gene

ENSEMBL:
Gene Tree for SNX30 (if available)
TreeFam:
Gene Tree for SNX30 (if available)

Paralogs for SNX30 Gene

Paralogs for SNX30 Gene

(4) SIMAP similar genes for SNX30 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNX30: view

Variants for SNX30 Gene

Sequence variations from dbSNP and Humsavar for SNX30 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000042721 -- 112,830,548(+) GACAG(G/T)GTATT intron-variant
rs1000056041 -- 112,869,149(+) CTGAC(A/G)CTCTG intron-variant, utr-variant-3-prime
rs1000079018 -- 112,783,302(+) TCTTT(C/T)AACTT intron-variant
rs1000095728 -- 112,789,602(+) GAATG(A/G)ACAGG intron-variant
rs1000097448 -- 112,829,923(+) TGCCT(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX30 Gene

Variant ID Type Subtype PubMed ID
dgv262e55 CNV gain 17911159
dgv7701n100 CNV gain 25217958
dgv7702n100 CNV loss 25217958
esv1549334 CNV insertion 17803354
esv2422302 CNV deletion 17116639
esv2759710 CNV gain 17122850
esv2761275 CNV gain 21179565
esv3621517 CNV gain 21293372
esv3621521 CNV gain 21293372
esv995366 CNV loss 20482838
nsv1119567 CNV insertion 24896259
nsv1132982 CNV insertion 24896259
nsv1149867 CNV insertion 26484159
nsv442163 CNV gain 18776908
nsv471317 CNV gain 18288195
nsv515121 CNV gain 21397061
nsv515899 CNV gain+loss 19592680
nsv615198 CNV gain 21841781
nsv825049 CNV gain 20364138
nsv8559 CNV gain 18304495
nsv8560 CNV loss 18304495

Variation tolerance for SNX30 Gene

Residual Variation Intolerance Score: 53.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX30 Gene

Disorders for SNX30 Gene

Relevant External Links for SNX30

Genetic Association Database (GAD)
SNX30
Human Genome Epidemiology (HuGE) Navigator
SNX30
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX30

No disorders were found for SNX30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX30 Gene

Publications for SNX30 Gene

  1. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A … Vieira AR (American journal of medical genetics. Part A 2010) 3 45 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 60
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  5. Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. (PMID: 22745667) Asbach B … Wagner R (PloS one 2012) 3 60

Products for SNX30 Gene

Sources for SNX30 Gene

Content
Loading form....