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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNX3 Gene

protein-coding   GIFtS: 60
GCID: GC06M108578

sorting nexin 3
 Explore 6 diseases affiliated with
SNX3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNX3    

Aliases
for SNX3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sorting Nexin 31 2     Sorting Nexin 3A2
Grd191 2     Sorting Nexin-32
MCOPS82     Protein SDP33
SDP32     

External Ids:    HGNC: 111741   Entrez Gene: 87242   Ensembl: ENSG000001123357   OMIM: 6059305   UniProtKB: O604933   

Export aliases for SNX3 gene to outside databases

Previous GC identifers: GC06M108382 GC06M108555 GC06M108639 GC06M106100


Summaries
for SNX3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SNX3:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a
phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled
coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved
in protein trafficking. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SNX3_HUMAN, O60493
Function: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds
phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments.
Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By
similarity). Not involved in EGFR degradation

Gene Wiki entry for SNX3


Genomic Views
for SNX3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNX3 gene promoter:
         C/EBPbeta   Pax-6   Nkx2-5   LCR-F1   RORalpha2   MEF-2A   GCNF-1   c-Myb   aMEF-2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

SNX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M108578:  view genomic region     (about GC identifiers)

Start:
 108,532,426 bp from pter      End:
 108,582,464 bp from pter
Size:
 50,039 bases      Orientation:
 minus strand

Proteins
for SNX3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SNX3_HUMAN, O60493 (See protein sequence)
Recommended Name: Sorting nexin-3  
Size: 162 amino acids; 18762 Da
Subunit: Interacts with USP10 and SCNN1A (By similarity)
Subcellular location: Early endosome
Secondary accessions: A8K0B1 E1P5E4 E1P5E5 O60718 Q4TT29 Q4TT31 Q5JXJ7 Q5JXJ8 Q96AP9 Q9C0J5 Q9NU45
Alternative splicing: 4 isoforms:  O60493-1   O60493-2   O60493-3   O60493-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SNX3: NX_O60493

Post-translational modifications:

  • Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60493

    • SNX3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_003786.1  NP_690040.1  

    ENSEMBL proteins: 
     ENSP00000230085   ENSP00000401779   ENSP00000357975   ENSP00000296991   ENSP00000357978  

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    Novus Biologicals SNX3 Proteins
    Novus Biologicals SNX3 Lysate
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    ProSpec Recombinant Protein for SNX3
    Uscn Proteins for SNX3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11279102
    GO:0005769early endosome IDA11433298
    GO:0010008endosome membrane IDA15673616


    SNX3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SNX3

    Protein Domains /
    Families
    for SNX3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNX3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001683 Phox

    Graphical View of Domain Structure for InterPro Entry O60493

    ProtoNet protein and cluster: O60493

    1 Blocks protein family: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SNX3_HUMAN, O60493
    Domain: The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3))
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain


    Function
    for SNX3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SNX3_HUMAN, O60493
    Function: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds
    phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments.
    Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By
    similarity). Not involved in EGFR degradation

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX3
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX3:
    hsa-miR-3659 hsa-miR-340 hsa-miR-107 hsa-let-7f-2* hsa-miR-570 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmid: SNX3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX3 

    Cell Line
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    Search LifeMap BioReagents cell lines for SNX3

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17474147
    GO:0019903protein phosphatase binding IPI17622474
    GO:0032266phosphatidylinositol-3-phosphate binding IDA11433298


    SNX3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SNX3:
     Decreased nuclei size in G2M 


    Pathways & Interactions
    for SNX3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/24 Interacting proteins for SNX3 (O604931, 2, 3 ENSP000002300854) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461081, 3, ENSP000003005744EBI-1056609,EBI-886 I2D: score=1 STRING: ENSP00000300574
    STX11O755582, 3, ENSP000003565404MINT-63212 I2D: score=4 STRING: ENSP00000356540
    USP10Q146943, ENSP000002194734I2D: score=2 STRING: ENSP00000219473
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis TAS9819414
    GO:0007154cell communication IEA--
    GO:0015031protein transport IEA--


    SNX3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNX3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNX3

    1 DrugBank Compound for SNX3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S,S-(2-Hydroxyethyl)Thiocysteine-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about SNX3 

    Transcripts
    for SNX3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNX3 gene (3 alternative transcripts): 
    NM_003795.4  NM_152827.2  NM_152828.2  

    Unigene Cluster for SNX3:

    Sorting nexin 3
    Hs.12102  [show with all ESTs]
    Unigene Representative Sequence: AK289476
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230085(uc003psh.3 uc003psi.3) ENST00000426155 ENST00000368979(uc010kdi.3)
    ENST00000349379 ENST00000368982

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX3:
    hsa-miR-3659 hsa-miR-340 hsa-miR-107 hsa-let-7f-2* hsa-miR-570 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmid: SNX3 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SNX3
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX3

    Additional cDNA sequence: 

    AB047360.1 AF034546.1 AF062483.1 AK289476.1 BC008444.1 BC014580.1 BC015179.1 BT007114.1 
    CR456898.1 

    19 DOTS entries:

    DT.100059527  DT.449260  DT.100842483  DT.100842485  DT.100842486  DT.92453477  DT.100842475  DT.100894403 
    DT.95105957  DT.95105958  DT.101984531  DT.92453479  DT.95105994  DT.100649270  DT.100842478  DT.91650235 
    DT.100842484  DT.91995498  DT.92409179 

    24/586 AceView cDNA sequences (see all 586):

    CR601831 BQ771652 BM721206 T30797 CR606126 AA902239 CD101909 AI690547 
    BM997473 CD106303 AA632399 AI912286 CA428996 CN484993 AA594630 CD676800 
    BQ421684 BG779096 CF527981 BI711394 AV713101 BM761664 BU619247 BG393533 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SNX3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:              -                                                   
    SP2:                          -                                       
    SP3:        -     -           -                                       
    SP4:              -           -                                       
    SP5:              -           -     -                                 


    ECgene alternative splicing isoforms for SNX3

    Expression
    for SNX3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGATTAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SNX3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    BrainCerebral CortexBrain
    Neural TubeTelencephalonNeural Tube
    Primitive StreakNotochordPrimitive Streak
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SNX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNX3

    SOURCE GeneReport for Unigene cluster: Hs.12102
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    In Situ
    Assay Products:     
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    Orthologs
    for SNX3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SNX3 gene from 7/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SNX31 sorting nexin 3 83.64(n)
    94.41(a)    		   421772  NM_001006408.1  NP_001006408.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SNX36
    		 --
    		 94(a)
    		 1 ↔ 1
    		 1(190430245-190451069)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC685802 hypothetical protein MGC68580 79.34(n)    BC060460.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii snx31 sorting nexin 3 74.28(n)
    88.27(a)    		   563511  NM_001037106.1  NP_001032183.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG63593 intracellular protein transport 70(a)   87C3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea W06D4.53 PhoX homologous domain, present in p47phox
    and more    		 66(a)   I(9071506-9072611)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SNX3(YOR357C)4
    SNX31    		 Sorting nexin required to maintain late-Golgi resident more4
    Snx3p1    		 53.55(n)1
    51.64(a)1    		   15(1009712-1009224)4
    8545391, 4  NP_015002.31  NP_015002.14 


    ENSEMBL Gene Tree for SNX3 (if available)
    TreeFam Gene Tree for SNX3 (if available) 

    Paralogs
    for SNX3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNX3 gene
    SNX102  SNX112  SNX122  
    6 SIMAP similar genes for SNX3 using alignment to 1 protein entry:     SNX3_HUMAN:
    SNX12    SNX1    SNX11    SNX30    SNX2    SNX10

    SNX3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SNX3
    PGOHUM00000241445 PGOHUM00000233673


    Genomic Variants
    for SNX3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/842 NCBI SNPs in SNX3 are shown (see all 842)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1447028501,2
    		C,--108532461(+) ATTAT-/AAAAGC 2 -- ds50010--------
    rs5324411,2
    		C,F,A,H,--108532682(-) TCTCTA/GTGAGT 2 -- ds5001 ese320Minor allele frequency- G:0.10EA NA MN NS WA 2666
    rs1905153381,2
    		--108532828(+) TTTCCC/TTCATT 2 -- ut310--------
    rs5313931,2
    		F,A,H,--108532833(-) AGATTA/GATGAG 2 -- ut31 ese38Minor allele frequency- G:0.06EA NA NS WA 560
    rs1808619851,2
    		--108532849(+) GTGAAG/TGGTAT 2 -- ut310--------
    rs758541521,2
    		C,F,--108532862(+) CAAGCC/TTGGAG 2 -- ut311Minor allele frequency- T:0.09WA 118
    rs744160101,2
    		--108533075(+) CACTGC/TAGATT 2 -- ut310--------
    rs115375851,2
    		H--108533381(-) AAGCTA/GTACTC 4 Y C mis1 ese34Minor allele frequency- G:0.00NS EA 402
    rs1882439351,2
    		--108533548(+) GTATAA/GTTTTT 2 -- int10--------
    rs1504667881,2
    		--108533609(+) CTGATA/CTTGGC 2 -- int10--------

    HapMap Linkage Disequilibrium report for SNX3 (108532426 - 108582464 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SNX3
         1 CNV: 4505
    Human Gene Mutation Database (HGMD): SNX3

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    Disorders / Diseases
    for SNX3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNX3 for disorders           About GeneDecksing

    OMIM gene information: 605930    OMIM disorders: --

    UniProtKB/Swiss-Prot: SNX3_HUMAN, O60493
  • A chromosomal aberration involving SNX3 may be a cause of microphthalmia syndromic type 8 (MCOPS8)
    • [MIM:601349]. Translocation t(6;13)(q21;q12). Microphthalmia is a clinically heterogeneous disorder of eye formation,
    ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases,
    microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS8 is a
    very rare congenital syndrome characterized by microcephaly, microphthalmia, ectrodactyly of the lower limbs and
    prognathism. Intellectual deficit has been reported

    6 diseases for SNX3:    About MalaCards
    cleft lip/palate    cleft lip    ectrodactyly    anophthalmia
    microphthalmia    microcephaly

    2 diseases from the University of Copenhagen DISEASES database for SNX3:
    Microphthalmia     Microcephaly
    Human Genome Epidemiology (HuGE) Navigator: SNX3 (3 documents)

    Export disorders for SNX3 gene to outside databases

    Publications
    for SNX3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNX3 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with SNX3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of sorting nexin molecules and characterization of their association with receptors. (PubMed id 9819414)1, 2, 3, 9 Haft C.R.... Taylor S.I. (1998)
    2. Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype. (PubMed id 12471201)1, 2, 9 Vervoort V.S.... Schwartz C.E. (2002)
    3. Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. (PubMed id 18767904)1, 2 Pons V....Gruenberg J. (2008)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    8. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. (PubMed id 11433298)1, 2 Xu Y....Hong W. (2001)
    9. Absence of mutations in NR2E1 and SNX3 in five patients with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and related phenotypes. (PubMed id 17655765)1, 9 Kumar R.A....Simpson E.M. (2007)
    10. Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3. (PubMed id 18632802)1, 9 Boulkroun S....Staub O. (2008)

    External Searches for SNX3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SNX3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8724 HGNC: 11174 AceView: SNX3 Ensembl:ENSG00000112335 euGenes: HUgn8724
    ECgene: SNX3 H-InvDB: SNX3

    Other Databases showing SNX3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SNX3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNX3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNX3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNX3 gene:
    Search GeneIP for patents involving SNX3

    GeneCards and IP:
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