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Aliases for SNX29 Gene

Aliases for SNX29 Gene

  • Sorting Nexin 29 2 3 5
  • RUN Domain-Containing Protein 2A 3 4
  • RUN Domain Containing 2A 2 3
  • RUNDC2A 3 4
  • Sorting Nexin-29 3
  • A-388D4.1 3

External Ids for SNX29 Gene

Previous HGNC Symbols for SNX29 Gene

  • RUNDC2A

Previous GeneCards Identifiers for SNX29 Gene

  • GC16P012053
  • GC16P012146

Summaries for SNX29 Gene

GeneCards Summary for SNX29 Gene

SNX29 (Sorting Nexin 29) is a Protein Coding gene. GO annotations related to this gene include microtubule motor activity and phosphatidylinositol binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX29 Gene

Genomics for SNX29 Gene

Regulatory Elements for SNX29 Gene

Enhancers for SNX29 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G012120 0.9 ENCODE 24.2 +143.9 143942 0.8 PKNOX1 FEZF1 GLI4 ZNF2 FOS KLF7 SP3 TSHZ1 ZNF488 GLIS1 SNX29 ZC3H7A GC16P012120 ENSG00000238685
GH16G012097 1.3 ENCODE dbSUPER 15.2 +121.0 121033 1.6 FOXA2 PKNOX1 ATF1 MLX ARNT ARID4B DMAP1 ZNF48 YY1 TCF12 SNX29 PIR48189 ENSG00000261293
GH16G012091 1.3 Ensembl ENCODE dbSUPER 14.4 +115.6 115554 2.2 CTCF PKNOX1 MAX CEBPG ZNF644 RAD21 YY1 ZNF121 ZNF316 HNF4G SNX29 LOC642696 ENSG00000261293
GH16G012094 0.8 dbSUPER 15.2 +117.9 117854 0.5 SOX13 PKNOX1 ESRRA SAP130 ZMYM3 CEBPG RAD21 ZSCAN9 YY1 RARA SNX29 LOC642696 ENSG00000261293
GH16G012113 0.5 ENCODE 23.4 +137.3 137250 1.2 GATA3 POLR2A SMARCA4 NR2F2 SNX29 GC16P012120 PIR48189
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNX29 on UCSC Golden Path with GeneCards custom track

Promoters for SNX29 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083420 -34 1801 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS SP3

Genomic Location for SNX29 Gene

Chromosome:
16
Start:
11,976,734 bp from pter
End:
12,574,289 bp from pter
Size:
597,556 bases
Orientation:
Plus strand

Genomic View for SNX29 Gene

Genes around SNX29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX29 Gene

Proteins for SNX29 Gene

  • Protein details for SNX29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEQ0-SNX29_HUMAN
    Recommended name:
    Sorting nexin-29
    Protein Accession:
    Q8TEQ0
    Secondary Accessions:
    • B5MDW2
    • Q8N2X2
    • Q9HA26

    Protein attributes for SNX29 Gene

    Size:
    813 amino acids
    Molecular mass:
    91254 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14033.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for SNX29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX29 Gene

Post-translational modifications for SNX29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX29 Gene

Domains & Families for SNX29 Gene

Gene Families for SNX29 Gene

Protein Domains for SNX29 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX29 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TEQ0

UniProtKB/Swiss-Prot:

SNX29_HUMAN :
  • Belongs to the sorting nexin family.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX29: view

Function for SNX29 Gene

Gene Ontology (GO) - Molecular Function for SNX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX29: view
genes like me logo Genes that share phenotypes with SNX29: view

Animal Models for SNX29 Gene

MGI Knock Outs for SNX29:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNX29 Gene

Localization for SNX29 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX29 gene
Compartment Confidence
extracellular 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SNX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SNX29: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SNX29 Gene

Pathways & Interactions for SNX29 Gene

SuperPathways for SNX29 Gene

No Data Available

Interacting Proteins for SNX29 Gene

Selected Interacting proteins: Q8TEQ0-SNX29_HUMAN for SNX29 Gene via IID

Gene Ontology (GO) - Biological Process for SNX29 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNX29 Gene

Drugs & Compounds for SNX29 Gene

No Compound Related Data Available

Transcripts for SNX29 Gene

Unigene Clusters for SNX29 Gene

Sorting nexin 29:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX29 Gene

No ASD Table

Relevant External Links for SNX29 Gene

GeneLoc Exon Structure for
SNX29
ECgene alternative splicing isoforms for
SNX29

Expression for SNX29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX29 Gene

Protein differential expression in normal tissues from HIPED for SNX29 Gene

This gene is overexpressed in Fetal heart (31.4), Monocytes (13.9), and Peripheral blood mononuclear cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SNX29 Gene



Protein tissue co-expression partners for SNX29 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNX29 Gene:

SNX29

SOURCE GeneReport for Unigene cluster for SNX29 Gene:

Hs.458401

Evidence on tissue expression from TISSUES for SNX29 Gene

  • Nervous system(4.7)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with SNX29: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX29 Gene

Orthologs for SNX29 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX29 34 35
  • 97.29 (n)
dog
(Canis familiaris)
Mammalia SNX29 34 35
  • 89.59 (n)
cow
(Bos Taurus)
Mammalia SNX29 34 35
  • 89.3 (n)
mouse
(Mus musculus)
Mammalia Snx29 34 16 35
  • 85.16 (n)
rat
(Rattus norvegicus)
Mammalia Snx29 34
  • 84.83 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX29 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX29 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX29 34 35
  • 72.75 (n)
lizard
(Anolis carolinensis)
Reptilia SNX29 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx29 34
  • 67.7 (n)
zebrafish
(Danio rerio)
Actinopterygii snx29 34 35
  • 65.1 (n)
Dr.9983 34
fruit fly
(Drosophila melanogaster)
Insecta CG5439 35
  • 13 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToOne
Species where no ortholog for SNX29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX29 Gene

ENSEMBL:
Gene Tree for SNX29 (if available)
TreeFam:
Gene Tree for SNX29 (if available)

Paralogs for SNX29 Gene

(2) SIMAP similar genes for SNX29 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SNX29 Gene

genes like me logo Genes that share paralogs with SNX29: view

No data available for Paralogs for SNX29 Gene

Variants for SNX29 Gene

Sequence variations from dbSNP and Humsavar for SNX29 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000000671 -- 12,267,520(+) AGCCC(C/T)TTAGC intron-variant
rs1000001248 -- 12,210,713(+) CCATT(A/T)TCTCT intron-variant
rs1000004256 -- 12,324,670(+) CTGCT(A/G)CCTGC intron-variant
rs1000004766 -- 12,443,334(+) TTTGC(A/G)CAGAT intron-variant
rs1000007758 -- 12,180,744(+) CCTCC(C/T)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX29 Gene

Variant ID Type Subtype PubMed ID
dgv1299n106 CNV deletion 24896259
dgv2730n100 CNV loss 25217958
dgv2731n100 CNV gain 25217958
dgv2732n100 CNV loss 25217958
dgv481e199 CNV deletion 23128226
esv1005656 CNV loss 20482838
esv1207869 CNV insertion 17803354
esv1672031 CNV insertion 17803354
esv1735749 CNV insertion 17803354
esv23890 CNV loss 19812545
esv2658919 CNV deletion 23128226
esv2664429 CNV deletion 23128226
esv2666642 CNV deletion 23128226
esv2669944 CNV deletion 23128226
esv2713986 CNV deletion 23290073
esv2713987 CNV deletion 23290073
esv2713988 CNV deletion 23290073
esv2713989 CNV deletion 23290073
esv2751546 CNV loss 17911159
esv2758630 CNV loss 17122850
esv2760409 CNV loss 21179565
esv29309 CNV loss 19812545
esv3308847 CNV mobile element insertion 20981092
esv3337175 CNV duplication 20981092
esv3553125 CNV deletion 23714750
esv3637952 CNV loss 21293372
esv3637953 CNV loss 21293372
esv3637954 CNV loss 21293372
esv3637956 CNV loss 21293372
esv3637958 CNV loss 21293372
esv3637959 CNV gain 21293372
esv3637960 CNV gain 21293372
esv3637963 CNV loss 21293372
esv3892793 CNV loss 25118596
nsv1036612 CNV gain 25217958
nsv1038535 CNV loss 25217958
nsv1039338 CNV gain+loss 25217958
nsv1039492 CNV loss 25217958
nsv1039590 CNV gain 25217958
nsv1040358 CNV loss 25217958
nsv1042146 CNV loss 25217958
nsv1043959 CNV gain 25217958
nsv1046002 CNV loss 25217958
nsv1049011 CNV loss 25217958
nsv1050004 CNV loss 25217958
nsv1052973 CNV loss 25217958
nsv1070748 CNV deletion 25765185
nsv1123010 CNV deletion 24896259
nsv1123011 CNV deletion 24896259
nsv1134500 CNV deletion 24896259
nsv1140074 CNV deletion 24896259
nsv1160342 CNV deletion 26073780
nsv1736 CNV deletion 18451855
nsv437802 CNV loss 16327808
nsv474208 CNV novel sequence insertion 20440878
nsv478553 CNV novel sequence insertion 20440878
nsv478679 CNV novel sequence insertion 20440878
nsv478886 CNV novel sequence insertion 20440878
nsv507803 OTHER sequence alteration 20534489
nsv516932 CNV gain 19592680
nsv517039 CNV loss 19592680
nsv520000 CNV loss 19592680
nsv524986 CNV loss 19592680
nsv527197 CNV loss 19592680
nsv528018 CNV loss 19592680
nsv528952 CNV loss 19592680
nsv571458 CNV gain 21841781
nsv571460 CNV gain 21841781
nsv571461 CNV loss 21841781
nsv571462 CNV loss 21841781
nsv571463 CNV loss 21841781
nsv571464 CNV loss 21841781
nsv571465 CNV loss 21841781
nsv571466 CNV loss 21841781
nsv827555 CNV loss 20364138
nsv833141 CNV gain 17160897
nsv9348 CNV loss 18304495
nsv9349 CNV loss 18304495
nsv952923 CNV deletion 24416366
nsv952924 CNV deletion 24416366
nsv977110 CNV duplication 23825009

Variation tolerance for SNX29 Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX29 Gene

Disorders for SNX29 Gene

Relevant External Links for SNX29

Genetic Association Database (GAD)
SNX29
Human Genome Epidemiology (HuGE) Navigator
SNX29
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX29

No disorders were found for SNX29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX29 Gene

Publications for SNX29 Gene

  1. The Phox (PX) domain proteins and membrane traffic. (PMID: 16782399) Seet L.F. … Hong W. (Biochim. Biophys. Acta 2006) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for SNX29 Gene

Sources for SNX29 Gene

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