SNX27 Gene
protein-coding GIFtS: 51
GCID: GC01P151585
|
|
sorting nexin family member 27
| |
Aliases for SNX27 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Sorting Nexin Family Member 271 2 | | MGC204711 | | MY0141 2 | | Methamphetamine-Responsive Transcript 12 | | KIAA04881 3 | | Sorting Nexin-272 | | MRT12 5 | | |
Export aliases for SNX27 gene to outside databasesPrevious GC identifers: GC01P147367 GC01P148359 GC01P148801 GC01P148397 GC01P149851 GC01P122961 |
Summaries for SNX27 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for SNX27: This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteinsinvolved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All membersof this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse isresponsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into earlyendosomes, suggesting the analogous role for the human protein. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: SNX27_HUMAN, Q96L92Function: Involved in endocytic trafficking (By similarity). In T lymphocytes, participates in endocytic recyclingpathway. Recruits PSCDBP and HT4R to early endosomes (By similarity) Gene Wiki entry for SNX27
|
Genomic Views for SNX27 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SNX27 gene promoter: RFX1 AML1a Pax-5 Nkx2-5 Nkx5-1 MEF-2A SRY c-Myb aMEF-2 Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX27
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX27 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3SNX27 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P151585: view genomic region
(about GC identifiers)
Start:
|
151,584,541 bp from pter |
End:
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151,671,567 bp from pter |
Size:
|
87,027 bases |
Orientation:
|
plus strand |
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Proteins for SNX27 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SNX27_HUMAN, Q96L92 (See
protein sequence)Recommended Name: Sorting nexin-27 Size: 541 amino acids; 61265 Da
Subunit: Interacts with PSCDBP. Isoforms 1 and 2 directly interact with DGKZ. Isoforms 1 and 2 interact with HT4Risoform 5-HTA(A) (By similarity). Interacts with MCC
Subcellular location: Cytoplasm, cytosol. Early endosome. Note=In T-lymphocytes, recruited from the cytosol to sortingendosomes by phosphoinositide-3-kinase products
Sequence caution: Sequence=AAG43127.1; Type=Erroneous initiation;
Secondary accessions: Q32Q36 Q4AEJ5 Q5VWB0 Q5VWB1 Q5VWB2 Q6IPP6 Q86UB1 Q96D79 Q9H3K8Alternative splicing: 4 isoforms: Q96L92-1 Q96L92-3 Q96L92-2 Q96L92-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SNX27: NX_Q96L92
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96L92 SNX27 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112180.4 ENSEMBL proteins: ENSP00000357834 ENSP00000400333 ENSP00000357836 ENSP00000357831 Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SNX27 for ontologies About GeneDecksing
SNX27 Antibody Products: Assay Products for SNX27: |
Protein
Domains / Families for SNX27 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX27 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96L92ProtoNet protein and cluster: Q96L92 3 Blocks protein families: IPB000159 RA domain IPB001478 PDZ/DHR/GLGF domain IPB001683 Phox-like
UniProtKB/Swiss-Prot: SNX27_HUMAN, Q96L92Domain: The PDZ domain mediates the interaction with DGKZ, PSCDBP and HT4R and is responsible for vesicularlocalization (By similarity)Similarity: Belongs to the sorting nexin familySimilarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 1 PX (phox homology) domainSimilarity: Contains 1 Ras-associating domain |
Function for SNX27 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SNX27_HUMAN, Q96L92Function: Involved in endocytic trafficking (By similarity). In T lymphocytes, participates in endocytic recyclingpathway. Recruits PSCDBP and HT4R to early endosomes (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX27 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX27 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SNX27 (NM_030918) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX27 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SNX27 for ontologies About GeneDecksing
Animal Models: Mouse knock-out Snx27tm1Lslo for SNX27 8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Snx27):
SNX27 for phenotypes About GeneDecksing
|
Pathways & Interactions for SNX27 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNX27
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
 5/21 Interacting proteins for SNX27 (Q96L922, 3 ENSP000003578364) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SNX27 for ontologies About GeneDecksing
|
Drugs & Compounds for SNX27 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SNX27 Search CenterWatch for drugs/clinical trials and news about SNX27 
|
Transcripts for SNX27 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SNX27 gene: NM_030918.5 Unigene Cluster for SNX27: Sorting nexin family member 27 Hs.192326 [show with all ESTs]Unigene Representative Sequence: NM_0309185 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368841(uc001eyo.3) ENST00000458013(uc001eyp.3) ENST00000368843(uc001eyn.1) ENST00000368838 ENST00000482791
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX27 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX27 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SNX27 (NM_030918) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX27 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX27  |
Additional cDNA sequence: AF060509.1 AJ009640.1 AK001395.1 AY044866.1 BC012184.1 BC051817.1 BC071825.1 BC100998.1 BC100999.1 BC101000.1 BC101822.1 BC101824.1 BC107862.1 BC127853.1 BC127854.1 13 DOTS entries: DT.100009569 DT.443740 DT.100749458 DT.40234407 DT.40107009 DT.121404701 DT.97817778 DT.100749455 DT.217541 DT.121502720 DT.91731716 DT.92019059 DT.97764375 24/267 AceView cDNA sequences (see all 267): BU951018 AV726824 BU676479 BU623265 R81952 BG570901 BU952464 AI678358 AA633943 BM704187 BM314517 AW271766 BC012184 CA439434 AB054889 BM980059 AA283733 NM_030918 AI089923 BQ008510 AY044866 AV708925 BG291397 BM849526 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SNX27 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for SNX27
|
Expression for SNX27 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX27 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CACATTTAAT
About this image See SNX27 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SNX27
SOURCE GeneReport for Unigene cluster: Hs.192326 UniProtKB/Swiss-Prot: SNX27_HUMAN, Q96L92Tissue specificity: Expressed in cells of hematopoietic origin (at protein level) SABiosciences Custom PCR Arrays for SNX27
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX27 Browse OriGene validated miRNA SYBR primer pairs
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| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX27 |
Orthologs for SNX27 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNX27 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
SNX271 |
sorting nexin family member 27 |
80.89(n) 94.84(a) |
  |
425666 NM_001031346.1 NP_001026517.1 |
lizard (Anolis carolinensis) |
Reptilia |
SNX276 |
-- |
84(a) |
1 ↔ 1 |
GL343554.1(25173-52965) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.98862 |
Xenopus laevis transcribed sequence with strong similarity more |
80.06(n) |
  |
CA788990.1 |
zebrafish (Danio rerio) |
Actinopterygii |
zgc660942 |
hypothetical protein MGC66094 |
76.91(n) |
  |
393512 BC056315.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG327581 |
CG32758 |
56.97(n) 54.58(a) |
  |
31493 NM_167045.1 NP_727023.1 |
worm (Caenorhabditis elegans) |
Secernentea |
snx-271 |
Protein SNX-27 |
52.51(n) 45.19(a) |
  |
172937 NM_060357.3 NP_492758.1 |
ENSEMBL Gene Tree for SNX27 (if available) TreeFam Gene Tree for SNX27 (if available)  |
Paralogs for SNX27 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SNX27 gene
- SNX172 SNX312
2 SIMAP similar genes for SNX27 using alignment to 2 protein entries: SNX27_HUMAN (see all proteins):SNX17 ARHGAP23
SNX27 for paralogs About GeneDecksing
|
Genomic Variants for SNX27 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX27 (151584541 - 151671567 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SNX27: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX27 |
|
Disorders
/ Diseases for SNX27 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNX27 for disorders About MalaCards
SNX27 for disorders About GeneDecksing
OMIM gene information: 611541
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: SNX27 (1 document) Export disorders for SNX27 gene to outside databases
|
Publications for SNX27 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX27 gene, integrated from 9 sources (see all 31): (articles sorted by number of sources associating them with SNX27) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. (PubMed id 17351151)1, 2, 9 Rincon E.... Merida I. (2007)
- Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes. (PubMed id 17577583)1, 2, 9 MacNeil A.J.... Pohajdak B. (2007)
- MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. (PubMed id 19555689)1, 2 Arnaud C....Lecine P. (2009)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting. (PubMed id 15466885)1, 2 Joubert L....Bockaert J. (2004)
- Sorting out the cellular functions of sorting nexins. (PubMed id 12461558)1, 3 Worby C.A. and Dixon J.E. (2002)
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
- A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. (PubMed id 17828261)1, 9 Lunn M.L....Slesinger P.A. (2007)
- Subunit-specific regulation of Kir3 channels by sorting nexin 27. (PubMed id 18690037)1, 9 Nassirpour R. and Slesinger P.A. (2007)
- Sorting nexin 27 interacts with multidrug resistance-a ssociated protein 4 (MRP4) and mediates internalization of MRP4. (PubMed id 22411990)1 Hayashi H....Sugiyama Y. (2012)
|
External Searches for SNX27 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SNX27 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX27 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SNX27 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SNX27 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX27 gene: Search GeneIP for patents involving SNX27
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SNX27 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX27 |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX27 |
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