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Aliases for SNX27 Gene

Aliases for SNX27 Gene

  • Sorting Nexin Family Member 27 2 3
  • MRT1 3 6
  • Methamphetamine-Responsive Transcript 1 3
  • Sorting Nexin-27 3
  • KIAA0488 4
  • MY014 3

External Ids for SNX27 Gene

Summaries for SNX27 Gene

Entrez Gene Summary for SNX27 Gene

  • This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX27 Gene

SNX27 (Sorting Nexin Family Member 27) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding. An important paralog of this gene is SNX17.

UniProtKB/Swiss-Prot for SNX27 Gene

  • Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.

Gene Wiki entry for SNX27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX27 Gene

Genomics for SNX27 Gene

Genomic Location for SNX27 Gene

Start:
151,611,988 bp from pter
End:
151,699,091 bp from pter
Size:
87,104 bases
Orientation:
Plus strand

Genomic View for SNX27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX27 Gene

Regulatory Elements for SNX27 Gene

Proteins for SNX27 Gene

  • Protein details for SNX27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L92-SNX27_HUMAN
    Recommended name:
    Sorting nexin-27
    Protein Accession:
    Q96L92
    Secondary Accessions:
    • Q32Q36
    • Q4AEJ5
    • Q5VWB0
    • Q5VWB1
    • Q5VWB2
    • Q6IPP6
    • Q86UB1
    • Q96D79
    • Q9H3K8

    Protein attributes for SNX27 Gene

    Size:
    541 amino acids
    Molecular mass:
    61265 Da
    Quaternary structure:
    • Core component of the SNX27-retromer, a multiprotein complex composed of SNX27, the WASH complex and the retromer complex. Interacts (via PDZ domain) with a number of target transmembrane proteins (via PDZ-binding motif): ABCC4, ADRB2, ARHGEF7, GRIA1, GRIA2, GRIN1, GRIN2A GRIN2C, KCNJ6, KCNJ9 and SLC2A1/GLUT1. Interacts (via the FERM-like regions) with the WASH complex. Interacts with SNX1. Interacts with CYTIP. Isoform 1 and isoform 2 directly interact with DGKZ. Isoform 1 and isoform 2 interact with HT4R isoform 5-HTA(A). Interacts with MCC.
    SequenceCaution:
    • Sequence=AAG43127.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNX27 Gene

    Alternative splice isoforms for SNX27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX27 Gene

Proteomics data for SNX27 Gene at MOPED

Post-translational modifications for SNX27 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys222 and Lys404

Other Protein References for SNX27 Gene

No data available for DME Specific Peptides for SNX27 Gene

Domains for SNX27 Gene

Gene Families for SNX27 Gene

HGNC:
  • SNX :Sorting nexins

Protein Domains for SNX27 Gene

UniProtKB/Swiss-Prot:

SNX27_HUMAN
Domain:
  • The PDZ domain mediates binding to a subset of proteins containing a PDZ-binding motif at the C-terminus: the specificity for PDZ-binding motif is provided by the 2 residues located upstream of the canonical PDZ-binding motif (By similarity). The PDZ domain also mediates binding to the retromer complex via direct interaction with VPS26 (VPS26A or VPS26B) (PubMed:23563491).:
    • Q96L92
  • The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3P)) and localization to early endosome membranes.:
    • Q96L92
  • Contains 1 PDZ (DHR) domain.:
    • Q96L92
  • Contains 1 PX (phox homology) domain.:
    • Q96L92
  • Contains 1 Ras-associating domain.:
    • Q96L92
Family:
  • Belongs to the sorting nexin family.:
    • Q96L92
genes like me logo Genes that share domains with SNX27: view

Function for SNX27 Gene

Molecular function for SNX27 Gene

UniProtKB/Swiss-Prot Function: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.

Gene Ontology (GO) - Molecular Function for SNX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19555689
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 21300787
GO:0035091 phosphatidylinositol binding --
genes like me logo Genes that share ontologies with SNX27: view
genes like me logo Genes that share phenotypes with SNX27: view

Animal Models for SNX27 Gene

MGI Knock Outs for SNX27:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SNX27 Gene

Localization for SNX27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX27 Gene

Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX27 Gene COMPARTMENTS Subcellular localization image for SNX27 gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 4
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SNX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 17644068
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005768 endosome --
genes like me logo Genes that share ontologies with SNX27: view

Pathways for SNX27 Gene

SuperPathways for SNX27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001770 establishment of natural killer cell polarity TAS 17644068
GO:0006886 intracellular protein transport IMP 20733053
GO:0007165 signal transduction IEA --
GO:0008333 endosome to lysosome transport IEA --
GO:0016197 endosomal transport IMP 21300787
genes like me logo Genes that share ontologies with SNX27: view

No data available for Pathways by source for SNX27 Gene

Transcripts for SNX27 Gene

Unigene Clusters for SNX27 Gene

Sorting nexin family member 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX27 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - -
SP2: - - -
SP3: -
SP4: - - -
SP5:

Relevant External Links for SNX27 Gene

GeneLoc Exon Structure for
SNX27
ECgene alternative splicing isoforms for
SNX27

Expression for SNX27 Gene

mRNA expression in normal human tissues for SNX27 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX27 Gene

SOURCE GeneReport for Unigene cluster for SNX27 Gene Hs.192326

mRNA Expression by UniProt/SwissProt for SNX27 Gene

Q96L92-SNX27_HUMAN
Tissue specificity: Widely expressed. Expressed in cells of hematopoietic origin (at protein level).
genes like me logo Genes that share expressions with SNX27: view

Orthologs for SNX27 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX27 36
  • 99.87 (n)
  • 100 (a)
SNX27 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX27 36
  • 95.18 (n)
  • 99.05 (a)
SNX27 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX27 36
  • 94.49 (n)
  • 98.48 (a)
SNX27 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx27 36
  • 93.26 (n)
  • 98.66 (a)
Snx27 16
Snx27 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX27 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx27 36
  • 93 (n)
  • 98.66 (a)
chicken
(Gallus gallus)
Aves SNX27 36
  • 80.62 (n)
  • 94.44 (a)
SNX27 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX27 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9886 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5084 36
zebrafish
(Danio rerio)
Actinopterygii snx27a 37
  • 72 (a)
OneToMany
snx27b 36
  • 76.27 (n)
  • 87.86 (a)
zgc66094 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001110 36
  • 57.66 (n)
  • 55.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32758 36
  • 57.24 (n)
  • 55.09 (a)
CG32758 37
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snx-27 36
  • 52.51 (n)
  • 45.19 (a)
snx-27 37
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 52 (a)
OneToOne
Species with no ortholog for SNX27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX27 Gene

ENSEMBL:
Gene Tree for SNX27 (if available)
TreeFam:
Gene Tree for SNX27 (if available)

Paralogs for SNX27 Gene

Paralogs for SNX27 Gene

Selected SIMAP similar genes for SNX27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNX27: view

Variants for SNX27 Gene

Sequence variations from dbSNP and Humsavar for SNX27 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs959290 -- 151,677,865(-) TTGAG(A/G)CAATA intron-variant
rs1048694 -- 151,697,521(+) AACAA(A/C)GCACC utr-variant-3-prime
rs1048700 -- 151,698,238(+) TGGAG(C/T)AGCAA utr-variant-3-prime
rs1196344 -- 151,636,546(-) AGATG(A/G)ATCAC intron-variant
rs1196345 -- 151,636,342(-) cctgg(A/G)ttaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX27 Gene

Variant ID Type Subtype PubMed ID
nsv2843 CNV Loss 18451855

Relevant External Links for SNX27 Gene

HapMap Linkage Disequilibrium report
SNX27

Disorders for SNX27 Gene

Relevant External Links for SNX27

Genetic Association Database (GAD)
SNX27
Human Genome Epidemiology (HuGE) Navigator
SNX27
genes like me logo Genes that share disorders with SNX27: view

No data available for UniProtKB/Swiss-Prot for SNX27 Gene

Publications for SNX27 Gene

  1. Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. (PMID: 17351151) Rincon E. … Merida I. (Mol. Cell. Proteomics 2007) 3 4 23
  2. Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes. (PMID: 17577583) MacNeil A.J. … Pohajdak B. (Biochem. Biophys. Res. Commun. 2007) 3 4 23
  3. Polarization of endosomal SNX27 in migrating and tumor-engaged natural killer cells. (PMID: 17644068) MacNeil A.J. … Pohajdak B. (Biochem. Biophys. Res. Commun. 2007) 3 4 23
  4. A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. (PMID: 17828261) Lunn M.L. … Slesinger P.A. (Nat. Neurosci. 2007) 3 23
  5. Subunit-specific regulation of Kir3 channels by sorting nexin 27. (PMID: 18690037) Nassirpour R. … Slesinger P.A. (Channels (Austin) 2007) 3 23

Products for SNX27 Gene

Sources for SNX27 Gene

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