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SNX27 Gene

protein-coding   GIFtS: 55
GCID: GC01P151585

Sorting Nexin Family Member 27

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sorting Nexin Family Member 271 2
MRT12 5
MY0142
Methamphetamine-Responsive Transcript 12
Sorting Nexin-272
KIAA04883

External Ids:    HGNC: 200731   Entrez Gene: 816092   Ensembl: ENSG000001433767   OMIM: 6115415   UniProtKB: Q96L923   

Export aliases for SNX27 gene to outside databases

Previous GC identifers: GC01P147367 GC01P148359 GC01P148801 GC01P148397 GC01P149851 GC01P122961


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNX27 Gene:
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated
proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments.
All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar
protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4
receptor into early endosomes, suggesting the analogous role for the human protein. (provided by RefSeq, Jul
2008)

GeneCards Summary for SNX27 Gene:
SNX27 (sorting nexin family member 27) is a protein-coding gene. Diseases associated with SNX27 include malaria. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding. An important paralog of this gene is SNX17.

UniProtKB/Swiss-Prot: SNX27_HUMAN, Q96L92
Function: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that
promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed
transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being
degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins
containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins,
associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule
based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing
phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity.
Recruits CYTIP to early endosomes

Gene Wiki entry for SNX27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNX27 gene promoter:
         RFX1   AML1a   Pax-5   Nkx2-5   Nkx5-1   MEF-2A   SRY   c-Myb   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNX27 promoter sequence
   Search Chromatin IP Primers for SNX27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNX27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

SNX27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX27 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151585:  view genomic region     (about GC identifiers)

Start:
151,584,541 bp from pter      End:
151,671,567 bp from pter
Size:
87,027 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SNX27_HUMAN, Q96L92 (See protein sequence)
Recommended Name: Sorting nexin-27  
Size: 541 amino acids; 61265 Da
Subunit: Core component of the SNX27-retromer, a multiprotein complex composed of SNX27, the WASH complex and the
retromer complex. Interacts (via PDZ domain) with a number of target transmembrane proteins (via PDZ-binding
motif): ABCC4, ADRB2, ARHGEF7, GRIA1, GRIA2, GRIN1, GRIN2A GRIN2C, KCNJ6, KCNJ9 and SLC2A1/GLUT1. Interacts (via
the FERM-like regions) with the WASH complex. Interacts with SNX1. Interacts with CYTIP. Isoform 1 and isoform 2
directly interact with DGKZ. Isoform 1 and isoform 2 interact with HT4R isoform 5-HTA(A). Interacts with MCC
Sequence caution: Sequence=AAG43127.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for SNX27:
4HAS (3D)    
Secondary accessions: Q32Q36 Q4AEJ5 Q5VWB0 Q5VWB1 Q5VWB2 Q6IPP6 Q86UB1 Q96D79 Q9H3K8
Alternative splicing: 4 isoforms:  Q96L92-1   Q96L92-3   Q96L92-2   Q96L92-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SNX27: NX_Q96L92

Explore proteomics data for SNX27 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys222, Lys404
  • Modification sites at PhosphoSitePlus

  • See SNX27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112180.4  
    ENSEMBL proteins: 
     ENSP00000357834   ENSP00000400333   ENSP00000357836   ENSP00000357831  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SNX: Sorting nexins

    4 InterPro protein domains:
     IPR001478 PDZ
     IPR001683 Phox
     IPR000159 Ras-assoc
     IPR028667 SNX27

    Graphical View of Domain Structure for InterPro Entry Q96L92

    ProtoNet protein and cluster: Q96L92

    3 Blocks protein domains:
    IPB000159 RA domain
    IPB001478 PDZ/DHR/GLGF domain
    IPB001683 Phox-like


    UniProtKB/Swiss-Prot: SNX27_HUMAN, Q96L92
    Domain: The PDZ domain mediates binding to a subset of proteins containing a PDZ-binding motif at the C-terminus:
    the specificity for PDZ-binding motif is provided by the 2 residues located upstream of the canonical PDZ-binding
    motif (By similarity). The PDZ domain also mediates binding to the retromer complex via direct interaction with
    VPS26 (VPS26A or VPS26B) (PubMed:23563491)
    Domain: The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3P)) and localization to early
    endosome membranes (PubMed:20733053)
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 1 Ras-associating domain


    SNX27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNX27_HUMAN, Q96L92
    Function: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that
    promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed
    transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being
    degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins
    containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins,
    associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule
    based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing
    phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity.
    Recruits CYTIP to early endosomes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19555689
    GO:0032266phosphatidylinositol-3-phosphate binding IDA--
    GO:0035091phosphatidylinositol binding ----
         
    SNX27 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Snx27):
     cardiovascular system  cellular  digestive/alimentary  growth/size/body  hematopoietic system 
     immune system  liver/biliary system  mortality/aging 

    SNX27 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Snx27tm1Lslo for SNX27

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNX27
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNX27_HUMAN, Q96L92: Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to
    immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by
    phosphoinositide-3-kinase products
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endosome5
    nucleus4
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA17644068
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005769early endosome IDA--

    SNX27 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNX27
    Interactions:

        GeneGlobe Interaction Network for SNX27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SNX27 (Q96L922, 3 ENSP000003578364) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHLPP2Q6ZVD83, ENSP000003486114I2D: score=2 STRING: ENSP00000348611
    MCCP235082, ENSP000003862274MINT-7211237 STRING: ENSP00000386227
    SCRIBQ141602MINT-7211237 MINT-7211267
    PHLPP1O603463I2D: score=2 
    CYTH1Q154383I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001770establishment of natural killer cell polarity TAS17644068
    GO:0006886intracellular protein transport IMP--
    GO:0007165signal transduction IEA--
    GO:0008333endosome to lysosome transport IEA--
    GO:0016197endosomal transport IMP--

    SNX27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for SNX27



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SNX27 gene: 
    NM_030918.5  

    Unigene Cluster for SNX27:

    Sorting nexin family member 27
    Hs.192326  [show with all ESTs]
    Unigene Representative Sequence: NM_030918
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368841(uc001eyo.3) ENST00000458013(uc001eyp.3) ENST00000368843(uc001eyn.1)
    ENST00000368838 ENST00000482791
    miRNA
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    hsa-miR-323-3p hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-376b hsa-miR-200a
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    Additional mRNA sequence: 

    AF060509.1 AJ009640.1 AK001395.1 AY044866.1 BC012184.1 BC051817.1 BC071825.1 BC100998.1 
    BC100999.1 BC101000.1 BC101822.1 BC101824.1 BC107862.1 BC127853.1 BC127854.1 

    13 DOTS entries:

    DT.100009569  DT.443740  DT.100749458  DT.40234407  DT.40107009  DT.121404701  DT.97817778  DT.100749455 
    DT.217541  DT.121502720  DT.91731716  DT.92019059  DT.97764375 

    Selected AceView cDNA sequences (see all 267):

    AI678358 AW271766 BC071825 AA005372 AA918266 AV726824 BU736441 BC012184 
    AL698715 AA311529 AI433572 BG003481 BQ008510 BQ426074 AI628463 BM314517 
    AA283733 CD105401 BU629929 CA310814 BP364341 BG291397 AI423005 CA418385 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SNX27    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
    SP1:                    -                                         -                                             
    SP2:              -     -                                         -                                             
    SP3:                                                              -                                             
    SP4:                                                              -                             -     -         
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SNX27

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNX27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACATTTAAT
    SNX27 Expression
    About this image

    SNX27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNX27 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.192326

    UniProtKB/Swiss-Prot: SNX27_HUMAN, Q96L92
    Tissue specificity: Widely expressed. Expressed in cells of hematopoietic origin (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SNX27 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snx271 , 5 sorting nexin family member 271, 5 93.26(n)1
    98.66(a)1
      3 (40.74 cM)5
    767421  NM_001082484.21  NP_001075953.11 
     944975445 
    chicken
    (Gallus gallus)
    Aves SNX271 sorting nexin family member 27 80.62(n)
    94.44(a)
      425666  NM_001031346.1  NP_001026517.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNX276
    sorting nexin family member 27
    84(a)
    1 ↔ 1
    GL343554.1(25173-52965)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98862 Xenopus laevis transcribed sequence with strong similarity more 80.06(n)    CA788990.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc660942 hypothetical protein MGC66094 76.91(n)   393512  BC056315.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG327581 CG32758 57.24(n)
    55.09(a)
      31493  NM_167045.2  NP_727023.1 
    worm
    (Caenorhabditis elegans)
    Secernentea snx-271 snx-27 52.51(n)
    45.19(a)
      172937  NM_060357.4  NP_492758.1 


    ENSEMBL Gene Tree for SNX27 (if available)
    TreeFam Gene Tree for SNX27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNX27 gene
    SNX172  SNX312  
    2 SIMAP similar genes for SNX27 using alignment to 2 protein entries:     SNX27_HUMAN (see all proteins):
    SNX17    ARHGAP23

    SNX27 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNX27 (see all 1769)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865385031,2
    --151582676(+) TGAAGA/CGATCC 1 -- us2k10--------
    rs1904967561,2
    --151582712(+) GGGACG/TACAGG 1 -- us2k10--------
    rs1117994721,2
    C--151582757(+) TTTTAG/TATATA 1 -- us2k10--------
    rs1384713621,2
    C--151582874(+) GGTCTC/GCCAAA 1 -- us2k10--------
    rs1413657501,2
    --151582911(+) CACACA/CCAGCC 1 -- us2k10--------
    rs1816123161,2
    --151583052(+) TTAATG/TTTATG 1 -- us2k10--------
    rs1451076621,2
    C--151583102(+) CACAAA/GCATAG 1 -- us2k10--------
    rs1389057111,2
    --151583321(+) ACCAGC/GTTGGC 1 -- us2k10--------
    rs1861944671,2
    --151583386(+) GTGGCA/GCATGC 1 -- us2k10--------
    rs1150975321,2
    C,F--151583399(+) TTAATC/TGCAAG 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for SNX27 (151584541 - 151671567 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SNX27:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2843CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNX27
    DNA2.0 Custom Variant and Variant Library Synthesis for SNX27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611541    OMIM disorders: --

    1 disease for SNX27:    
    About MalaCards
    malaria


    SNX27 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SNX27
    Human Genome Epidemiology (HuGE) Navigator: SNX27 (1 document)

    Export disorders for SNX27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNX27 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SNX27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. (PubMed id 17351151)1, 2, 9 Rincon E.... Merida I. (Mol. Cell. Proteomics 2007)
    2. Polarization of endosomal SNX27 in migrating and tumor-engaged natural killer cells. (PubMed id 17644068)1, 2, 9 MacNeil A.J. and Pohajdak B. (Biochem. Biophys. Res. Commun. 2007)
    3. Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes. (PubMed id 17577583)1, 2, 9 MacNeil A.J.... Pohajdak B. (Biochem. Biophys. Res. Commun. 2007)
    4. A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. (PubMed id 23563491)1, 2 Steinberg F.... Cullen P.J. (Nat. Cell Biol. 2013)
    5. Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4. (PubMed id 22411990)1, 2 Hayashi H....Sugiyama Y. (J. Biol. Chem. 2012)
    6. SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. (PubMed id 21602791)1, 2 Temkin P....von Zastrow M. (Nat. Cell Biol. 2011)
    7. Translocation dynamics of sorting nexin 27 in activated T cells. (PubMed id 21303929)1, 2 Rincon E.... Merida I. (J. Cell Sci. 2011)
    8. Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C). (PubMed id 21300787)1, 2 Cai L.... Hong W. (Mol. Cell. Biol. 2011)
    9. Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (beta-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction. (PubMed id 21926430)1, 2 Valdes J.L.... Playford M.P. (J. Biol. Chem. 2011)
    10. SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. (PubMed id 20733053)1, 2 Lauffer B.E....von Zastrow M. (J. Cell Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81609 HGNC: 20073 AceView: SNX27 Ensembl:ENSG00000143376 euGenes: HUgn81609
    ECgene: SNX27 H-InvDB: SNX27

    (According to HUGE)
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    HUGE: KIAA0488

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNX27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNX27 gene:
    Search GeneIP for patents involving SNX27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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