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Aliases for SNX25 Gene

Aliases for SNX25 Gene

  • Sorting Nexin 25 2 3 5
  • Sorting Nexin-25 3
  • MSTP043 3
  • SBBI31 3

External Ids for SNX25 Gene

Previous GeneCards Identifiers for SNX25 Gene

  • GC04P186865
  • GC04P186715
  • GC04P186881
  • GC04P186827
  • GC04P186506
  • GC04P186362
  • GC04P186131
  • GC04P181922

Summaries for SNX25 Gene

GeneCards Summary for SNX25 Gene

SNX25 (Sorting Nexin 25) is a Protein Coding gene. Diseases associated with SNX25 include Neuropathy, Congenital Hypomyelinating. GO annotations related to this gene include phosphatidylinositol binding and type I transforming growth factor beta receptor binding. An important paralog of this gene is SNX13.

UniProtKB/Swiss-Prot for SNX25 Gene

  • May be involved in several stages of intracellular trafficking.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX25 Gene

Genomics for SNX25 Gene

Regulatory Elements for SNX25 Gene

Enhancers for SNX25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G185303 1.5 Ensembl ENCODE dbSUPER 11 +102.2 102186 5.2 HDGF FOXA2 WRNIP1 ZFP64 SIN3A YY1 ZNF143 FOS JUNB REST CFAP97 LRP2BP SNX25 LOC105377591
GH04G185255 0.9 Ensembl ENCODE 18.3 +52.0 51973 1.6 PKNOX1 BHLHE40 NSD2 DPF2 ZNF316 NFE2 ETV6 IRF1 FOS SNX25 CFAP97 UFSP2 LOC105377591
GH04G185235 1.1 Ensembl ENCODE 11.9 +31.7 31666 1.1 HDAC1 ELF3 PKNOX1 FOXA2 ATF1 INSM2 ARID4B ZNF48 RARA ZNF121 CFAP97 SNX25 LOC105377591
GH04G185265 0.7 ENCODE 17.4 +61.9 61872 1.4 HDAC1 PKNOX1 MAFG SIN3A ARID1B JUND ZNF316 GATA2 NFYB HMBOX1 SNX25 CFAP97 LOC105377591
GH04G185238 0.7 ENCODE 11.9 +34.4 34366 1.0 NFIA ZSCAN4 MAFG CDC5L NFIC ZNF316 FOS WT1 MAFK HNRNPL CFAP97 SNX25 LOC105377591
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNX25 on UCSC Golden Path with GeneCards custom track

Promoters for SNX25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000177017 -337 1401 CREB3L1 ARID4B SIN3A DMAP1 ZNF766 ELK1 ZNF207 SP5 MIER2 ZNF592

Genomic Location for SNX25 Gene

185,204,237 bp from pter
185,370,185 bp from pter
165,949 bases
Plus strand

Genomic View for SNX25 Gene

Genes around SNX25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX25 Gene

Proteins for SNX25 Gene

  • Protein details for SNX25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-25
    Protein Accession:
    Secondary Accessions:
    • Q3ZT30
    • Q8N6K3

    Protein attributes for SNX25 Gene

    840 amino acids
    Molecular mass:
    97945 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG39294.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SNX25 Gene


neXtProt entry for SNX25 Gene

Post-translational modifications for SNX25 Gene

  • Ubiquitination at isoforms=197
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SNX25 Gene

Domains & Families for SNX25 Gene

Gene Families for SNX25 Gene

Protein Domains for SNX25 Gene

Suggested Antigen Peptide Sequences for SNX25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sorting nexin family.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX25: view

Function for SNX25 Gene

Molecular function for SNX25 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking.

Gene Ontology (GO) - Molecular Function for SNX25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0034713 type I transforming growth factor beta receptor binding IEA --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX25: view
genes like me logo Genes that share phenotypes with SNX25: view

Animal Models for SNX25 Gene

MGI Knock Outs for SNX25:

Animal Model Products

CRISPR Products

miRNA for SNX25 Gene

miRTarBase miRNAs that target SNX25

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNX25 Gene

Localization for SNX25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX25 Gene

Endosome membrane; Peripheral membrane protein. Note=Detected in endosome-derived secreted vesicles (exosomes) from malignant pleural effusions.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX25 gene
Compartment Confidence
endosome 4
cytosol 3
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for SNX25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005768 endosome IEA --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SNX25: view

Pathways & Interactions for SNX25 Gene

SuperPathways for SNX25 Gene

No Data Available

Interacting Proteins for SNX25 Gene

Gene Ontology (GO) - Biological Process for SNX25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IMP 21266196
GO:0032801 receptor catabolic process IMP 21266196
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation IMP 21266196
genes like me logo Genes that share ontologies with SNX25: view

No data available for Pathways by source and SIGNOR curated interactions for SNX25 Gene

Drugs & Compounds for SNX25 Gene

No Compound Related Data Available

Transcripts for SNX25 Gene

Unigene Clusters for SNX25 Gene

Sorting nexin 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX25 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP3: -
SP4: -

Relevant External Links for SNX25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNX25 Gene

This gene is overexpressed in Testis (28.2) and Heart (27.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX25 Gene

Protein tissue co-expression partners for SNX25 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNX25 Gene:


SOURCE GeneReport for Unigene cluster for SNX25 Gene:


Evidence on tissue expression from TISSUES for SNX25 Gene

  • Heart(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SNX25: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX25 Gene

Orthologs for SNX25 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNX25 34 35
  • 99.56 (n)
(Canis familiaris)
Mammalia SNX25 34 35
  • 93.37 (n)
(Monodelphis domestica)
Mammalia SNX25 35
  • 90 (a)
(Bos Taurus)
Mammalia SNX25 34 35
  • 89.48 (n)
(Rattus norvegicus)
Mammalia Snx25 34
  • 86.93 (n)
(Mus musculus)
Mammalia Snx25 34 16 35
  • 85.46 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
-- 35
  • 78 (a)
-- 35
  • 74 (a)
(Gallus gallus)
Aves SNX25 34 35
  • 79.5 (n)
(Anolis carolinensis)
Reptilia SNX25 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx25 34
  • 74.73 (n)
Str.19293 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.34411 34
(Danio rerio)
Actinopterygii snx25 34 35
  • 69.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta snz 34 35
  • 47.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000912 34
  • 44.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
Species where no ortholog for SNX25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX25 Gene

Gene Tree for SNX25 (if available)
Gene Tree for SNX25 (if available)

Paralogs for SNX25 Gene

Paralogs for SNX25 Gene Pseudogenes for SNX25 Gene

genes like me logo Genes that share paralogs with SNX25: view

Variants for SNX25 Gene

Sequence variations from dbSNP and Humsavar for SNX25 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000029578 -- 185,288,610(+) TTGGG(A/G)GGTGG intron-variant
rs10000719 -- 185,321,079(+) AAGGT(C/T)TTATA intron-variant
rs10000918 -- 185,347,422(+) atctc(A/G)ttgtg intron-variant
rs1000196546 -- 185,311,719(+) CTCTC(A/G)GTTCT intron-variant, reference, synonymous-codon
rs1000199165 -- 185,266,488(+) CCCGA(A/G)TAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX25 Gene

Variant ID Type Subtype PubMed ID
dgv2970n106 CNV deletion 24896259
dgv2971n106 CNV deletion 24896259
dgv342e215 CNV deletion 23714750
esv1000121 CNV deletion 20482838
esv1138598 CNV deletion 17803354
esv1669184 CNV deletion 17803354
esv1972847 CNV deletion 18987734
esv2155800 CNV deletion 18987734
esv22414 CNV loss 19812545
esv2309931 CNV deletion 18987734
esv2449161 CNV deletion 19546169
esv2466192 CNV deletion 19546169
esv2656802 CNV deletion 23128226
esv2671747 CNV deletion 23128226
esv2728904 CNV deletion 23290073
esv2728905 CNV deletion 23290073
esv2728907 CNV deletion 23290073
esv2728908 CNV deletion 23290073
esv2728909 CNV deletion 23290073
esv3565180 CNV deletion 23714750
esv3565183 CNV deletion 23714750
esv3603488 CNV loss 21293372
esv3603489 CNV loss 21293372
esv3603490 CNV loss 21293372
esv3603491 CNV loss 21293372
esv4547 CNV loss 18987735
esv4601 CNV loss 18987735
esv5569 CNV loss 19470904
esv5811 CNV loss 19470904
esv995230 CNV deletion 20482838
nsv1074251 CNV deletion 25765185
nsv1074781 CNV deletion 25765185
nsv1109658 CNV deletion 24896259
nsv1137513 CNV deletion 24896259
nsv1139341 CNV deletion 24896259
nsv428456 CNV gain+loss 18775914
nsv461859 CNV loss 19166990
nsv596369 CNV loss 21841781
nsv596371 CNV loss 21841781
nsv596372 CNV loss 21841781

Variation tolerance for SNX25 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX25 Gene

Disorders for SNX25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNX25 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuropathy, congenital hypomyelinating
  • dejerine-sottas disease
- elite association - COSMIC cancer census association via MalaCards
Search SNX25 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SNX25

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SNX25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNX25 Gene

Publications for SNX25 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby C.A. … Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics. (PMID: 26214276) Lee J.H. … Mayeux R. (JAMA Neurol 2015) 3 64
  5. Expression pattern of sorting Nexin 25 in temporal lobe epilepsy: a study on patients and pilocarpine-induced rats. (PMID: 23518199) Du Y. … LA1 Y. (Brain Res. 2013) 3 64

Products for SNX25 Gene

Sources for SNX25 Gene

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