SNX25 Gene
protein-coding GIFtS: 45
GCID: GC04P186131
|
|
sorting nexin 25
| |
Aliases
for SNX25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sorting Nexin 251 2 | | SBBI311 2 | | Sorting Nexin-252 |
Export aliases for SNX25 gene to outside databasesPrevious GC identifers: GC04P186865 GC04P186715 GC04P186881 GC04P186827 GC04P186506 GC04P186362 GC04P181922 |
Summaries
for SNX25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SNX25_HUMAN, Q9H3E2Function: May be involved in several stages of intracellular trafficking (By similarity)
|
Genomic Views
for SNX25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNX25 gene promoter:
ER-alpha AML1a POU3F1 AP-2gamma IRF-2 E2F E2F-1 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1SNX25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P186131: view genomic region
(about GC identifiers)
Start:
|
186,125,391 bp from pter |
End:
|
186,291,339 bp from pter |
Size:
|
165,949 bases |
Orientation:
|
plus strand |
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Proteins
for SNX25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNX25_HUMAN, Q9H3E2 (See
protein sequence)Recommended Name: Sorting nexin-25 Size: 840 amino acids; 97945 Da
Subcellular location: Endosome membrane; Peripheral membrane protein. Note=Detected in endosome-derived secretedvesicles (exosomes) from malignant pleural effusions
Sequence caution: Sequence=AAG39294.1; Type=Erroneous initiation;
Secondary accessions: Q3ZT30Explore the universe of human proteins at neXtProt for SNX25: NX_Q9H3E2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H3E2
SNX25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114159.2
ENSEMBL proteins: ENSP00000426255 ENSP00000264694 ENSP00000424826
Human Recombinant Protein Products for SNX25:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010008 | endosome membrane |
IEA | -- |
SNX25 for ontologies About GeneDecksing
SNX25 Antibody Products:
Assay Products for SNX25: |
Protein
Domains /
Families
for SNX25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX25 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H3E2ProtoNet protein and cluster: Q9H3E2 2 Blocks protein families: IPB001683 Phox-like IPB013937 Sorting nexin
UniProtKB/Swiss-Prot: SNX25_HUMAN, Q9H3E2Similarity: Belongs to the sorting nexin familySimilarity: Contains 1 PX (phox homology) domainSimilarity: Contains 1 PXA domainSimilarity: Contains 1 RGS domain |
Function
for SNX25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SNX25_HUMAN, Q9H3E2Function: May be involved in several stages of intracellular trafficking (By similarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035091 | phosphatidylinositol binding |
IEA | -- |
SNX25 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX25
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: SNX25 (NM_031953) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX25 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX25 |
|
Pathways & Interactions
for SNX25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX25
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SNX25 (ENSP000002646944) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007154 | cell communication |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0038032 | termination of G-protein coupled receptor signaling pathway |
IEA | -- |
SNX25 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNX25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNX25
Search CenterWatch for drugs/clinical trials and news about SNX25
|
Transcripts
for SNX25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNX25 gene: NM_031953.2 Unigene Cluster for SNX25: Sorting nexin 25 Hs.369091 [show with all ESTs]Unigene Representative Sequence: AY6016476 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000504273 ENST00000264694(uc003ixh.3 uc010ish.3) ENST00000506896
ENST00000512853 ENST00000504959(uc003ixi.3) ENST00000513433
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX25
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNX25 (NM_031953) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX25 |
Additional cDNA sequence: AF113223.1 AK026814.1 AK095661.1 AY044656.1 AY601647.1 BC029868.1 9 DOTS entries: DT.308219 DT.121224541 DT.40113916 DT.95269902 DT.40112263 DT.410170 DT.92028415 DT.95180654 DT.40272662 24/79 AceView cDNA sequences (see all 79): CA868291 AY044656 AA627829 BI763551 AA626308 BM472439 AA705542 AA481564 BX951557 N72268 CN479572 AA130263 NM_031953 CA868043 CB112931 AW968034 AF113223 BM504651 BC029868 BM504976 CA429206 AI129945 AW316756 BQ008931
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SNX25 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SNX25
|
Expression
for SNX25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATTGAAG
About this image
See SNX25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX25
SOURCE GeneReport for Unigene cluster: Hs.369091
SABiosciences Custom PCR Arrays for SNX25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX25 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX25 |
Orthologs
for SNX25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SNX25 gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for SNX25 (if available)
TreeFam Gene Tree for SNX25 (if available) |
Paralogs
for SNX25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNX25 gene
- SNX132 SNX192 SNX142
SNX25 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SNX25
PGOHUM00000245197
|
Genomic Variants
for SNX25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX25 (186125391 - 186291339 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for SNX25
2 CNVs: 98992 98991
10 Indels: 46578 42409 40713 68869 40714 62302 46579 42899 27551 62303 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX25 |
|
Disorders
/ Diseases
for SNX25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNX25 for disorders About GeneDecksing
4  diseases for SNX25: About MalaCardsdistal hereditary motor neuropathy facioscapulohumeral muscular dystrophy muscular dystrophy neuropathy
2 diseases from the University of Copenhagen DISEASES database for SNX25:Distal hereditary motor neuropathy Facioscapulohumeral muscular dystrophy Export disorders for SNX25 gene to outside databases
|
Publications
for SNX25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX25 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SNX25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Sorting out the cellular functions of sorting nexins. (PubMed id 12461558)1, 3 Worby C.A. and Dixon J.E. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- SNX25 regulates TGF-I^ signaling by enhancing the rece ptor degradation. (PubMed id 21266196)1 Hao X....Chang Z. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- (PubMed id 14975938)2
|
External Searches for SNX25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNX25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNX25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNX25 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX25 gene:
Search GeneIP for patents involving SNX25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNX25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SNX25 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX25 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX25 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for SNX25 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX25 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX25 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX25 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX25 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX25 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX25 |
| |
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| |  |  |  |  | | | | |
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 |
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 | | | SNX25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX25 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SNX25 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX25 |
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