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Aliases for SNX25 Gene

Aliases for SNX25 Gene

  • Sorting Nexin 25 2 3 5
  • MSTP043 3
  • SBBI31 3

External Ids for SNX25 Gene

Previous GeneCards Identifiers for SNX25 Gene

  • GC04P186865
  • GC04P186715
  • GC04P186881
  • GC04P186827
  • GC04P186506
  • GC04P186362
  • GC04P186131
  • GC04P181922

Summaries for SNX25 Gene

GeneCards Summary for SNX25 Gene

SNX25 (Sorting Nexin 25) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding and type I transforming growth factor beta receptor binding. An important paralog of this gene is SNX13.

UniProtKB/Swiss-Prot for SNX25 Gene

  • May be involved in several stages of intracellular trafficking.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX25 Gene

Genomics for SNX25 Gene

Regulatory Elements for SNX25 Gene

Enhancers for SNX25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNX25 on UCSC Golden Path with GeneCards custom track

Promoters for SNX25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNX25 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX25 Gene

185,204,237 bp from pter
185,370,185 bp from pter
165,949 bases
Plus strand

Genomic View for SNX25 Gene

Genes around SNX25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX25 Gene

Proteins for SNX25 Gene

  • Protein details for SNX25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-25
    Protein Accession:
    Secondary Accessions:
    • Q3ZT30
    • Q8N6K3

    Protein attributes for SNX25 Gene

    840 amino acids
    Molecular mass:
    97945 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG39294.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SNX25 Gene


neXtProt entry for SNX25 Gene

Proteomics data for SNX25 Gene at MOPED

Post-translational modifications for SNX25 Gene

  • Ubiquitination at Lys 197
  • Modification sites at PhosphoSitePlus

Other Protein References for SNX25 Gene

No data available for DME Specific Peptides for SNX25 Gene

Domains & Families for SNX25 Gene

Gene Families for SNX25 Gene

Protein Domains for SNX25 Gene

Suggested Antigen Peptide Sequences for SNX25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PX (phox homology) domain.
  • Belongs to the sorting nexin family.
  • Contains 1 PX (phox homology) domain.
  • Contains 1 PXA domain.
  • Contains 1 RGS domain.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX25: view

Function for SNX25 Gene

Molecular function for SNX25 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking.

Gene Ontology (GO) - Molecular Function for SNX25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX25: view

Phenotypes for SNX25 Gene

genes like me logo Genes that share phenotypes with SNX25: view

Animal Model Products

miRNA for SNX25 Gene

miRTarBase miRNAs that target SNX25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX25 Gene

Localization for SNX25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX25 Gene

Endosome membrane; Peripheral membrane protein. Note=Detected in endosome-derived secreted vesicles (exosomes) from malignant pleural effusions.

Subcellular locations from

Jensen Localization Image for SNX25 Gene COMPARTMENTS Subcellular localization image for SNX25 gene
Compartment Confidence
endosome 4
cytosol 3
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for SNX25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with SNX25: view

Pathways & Interactions for SNX25 Gene

SuperPathways for SNX25 Gene

No Data Available

Interacting Proteins for SNX25 Gene

Gene Ontology (GO) - Biological Process for SNX25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032801 receptor catabolic process IMP 21266196
genes like me logo Genes that share ontologies with SNX25: view

No data available for Pathways by source and SIGNOR curated interactions for SNX25 Gene

Drugs & Compounds for SNX25 Gene

No Compound Related Data Available

Transcripts for SNX25 Gene

Unigene Clusters for SNX25 Gene

Sorting nexin 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX25 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP3: -
SP4: -

Relevant External Links for SNX25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX25 Gene

mRNA expression in normal human tissues for SNX25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNX25 Gene

This gene is overexpressed in Testis (28.2) and Heart (27.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX25 Gene

SOURCE GeneReport for Unigene cluster for SNX25 Gene Hs.369091

genes like me logo Genes that share expression patterns with SNX25: view

Protein tissue co-expression partners for SNX25 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX25 Gene

Orthologs for SNX25 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SNX25 35
  • 89.48 (n)
  • 92.5 (a)
SNX25 36
  • 88 (a)
(Canis familiaris)
Mammalia SNX25 35
  • 93.37 (n)
  • 95 (a)
SNX25 36
  • 95 (a)
(Mus musculus)
Mammalia Snx25 35
  • 85.46 (n)
  • 87.37 (a)
Snx25 16
Snx25 36
  • 87 (a)
(Pan troglodytes)
Mammalia SNX25 35
  • 99.56 (n)
  • 99.4 (a)
SNX25 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Snx25 35
  • 86.93 (n)
  • 88.44 (a)
(Monodelphis domestica)
Mammalia SNX25 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
-- 36
  • 79 (a)
-- 36
  • 78 (a)
(Gallus gallus)
Aves SNX25 35
  • 79.5 (n)
  • 81.89 (a)
SNX25 36
  • 79 (a)
(Anolis carolinensis)
Reptilia SNX25 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx25 35
  • 74.73 (n)
  • 77.39 (a)
Str.19293 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.34411 35
(Danio rerio)
Actinopterygii snx25 35
  • 69.92 (n)
  • 73.7 (a)
snx25 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000912 35
  • 44.72 (n)
  • 35.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta snz 35
  • 47.83 (n)
  • 36.77 (a)
snz 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for SNX25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX25 Gene

Gene Tree for SNX25 (if available)
Gene Tree for SNX25 (if available)

Paralogs for SNX25 Gene

Paralogs for SNX25 Gene Pseudogenes for SNX25 Gene

genes like me logo Genes that share paralogs with SNX25: view

Variants for SNX25 Gene

Sequence variations from dbSNP and Humsavar for SNX25 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs35700132 - 185,320,832(-) AGATT(C/T)CCAAA nc-transcript-variant, reference, missense
rs3756275 - 185,346,597(+) AATCT(A/C/G)TAGAT nc-transcript-variant, reference, missense
rs34120554 - 185,361,938(-) TGACT(A/G)TGTCC reference, missense
rs753359 -- 185,306,378(-) GTTTG(A/C)TAATG intron-variant
rs1031128 -- 185,360,601(-) AGTTC(A/G)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX25 Gene

Variant ID Type Subtype PubMed ID
nsv461859 CNV Loss 19166990
esv22414 CNV Loss 19812545
esv2728904 CNV Deletion 23290073
esv2309931 CNV Deletion 18987734
esv2728905 CNV Deletion 23290073
esv2728907 CNV Deletion 23290073
esv1669184 CNV Deletion 17803354
esv2466192 CNV Deletion 19546169
esv1972847 CNV Deletion 18987734
esv4547 CNV Deletion 18987735
esv2728908 CNV Deletion 23290073
esv1000121 CNV Deletion 20482838
esv1138598 CNV Deletion 17803354
esv5569 CNV Loss 19470904
esv2656802 CNV Deletion 23128226
esv2449161 CNV Deletion 19546169
esv2155800 CNV Deletion 18987734
esv4601 CNV Deletion 18987735
esv2728909 CNV Deletion 23290073
esv995230 CNV Deletion 20482838
esv5811 CNV Loss 19470904
esv2671747 CNV Deletion 23128226
nsv428456 CNV Gain+Loss 18775914

Variation tolerance for SNX25 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SNX25 Gene

Disorders for SNX25 Gene

Relevant External Links for SNX25

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SNX25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX25 Gene

Publications for SNX25 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby C.A. … Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics. (PMID: 26214276) Lee J.H. … Mayeux R. (JAMA Neurol 2015) 3
  5. Expression pattern of sorting Nexin 25 in temporal lobe epilepsy: a study on patients and pilocarpine-induced rats. (PMID: 23518199) Du Y. … LA1 Y. (Brain Res. 2013) 3

Products for SNX25 Gene

Sources for SNX25 Gene