SNX24 Gene
protein-coding GIFtS: 44
GCID: GC05P122209
|
|
sorting nexin 24
| |
Aliases
for SNX24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sorting Nexin 241 2 | | SBBI311 | | PRO12842 | | Sorting Nexin-242 | | Sorting Nexing 242 |
Export aliases for SNX24 gene to outside databasesPrevious GC identifers: GC05P122508 GC05P122212 GC05P122257 GC05P117368 |
Summaries
for SNX24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SNX24_HUMAN, Q9Y343Function: May be involved in several stages of intracellular trafficking (By similarity)
|
Genomic Views
for SNX24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNX24 gene promoter:
STAT5B STAT1 STAT2 STAT4 STAT6 STAT3 STAT1beta STAT5A Cdc5 STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q23.2 Ensembl cytogenetic band: 5q23.2 HGNC cytogenetic band: 5q23.2SNX24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P122209: view genomic region
(about GC identifiers)
Start:
|
122,179,134 bp from pter |
End:
|
122,365,049 bp from pter |
Size:
|
185,916 bases |
Orientation:
|
plus strand |
|
Proteins
for SNX24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNX24_HUMAN, Q9Y343 (See
protein sequence)Recommended Name: Sorting nexin-24 Size: 169 amino acids; 19818 Da
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity)
1 PDB 3D structure from  and Proteopedia  for SNX24:4AZ9 (3D)
Secondary accessions: Q6UY33Alternative splicing: 2 isoforms: Q9Y343-1 Q9Y343-2 Explore the universe of human proteins at neXtProt for SNX24: NX_Q9Y343
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y343
SNX24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054754.1
ENSEMBL proteins: ENSP00000261369 ENSP00000424149 ENSP00000378837 ENSP00000422535 ENSP00000422184 ENSP00000425919
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030659 | cytoplasmic vesicle membrane |
IEA | -- |
SNX24 for ontologies About GeneDecksing
SNX24 Antibody Products:
Assay Products for SNX24: |
Protein
Domains /
Families
for SNX24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX24 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y343ProtoNet protein and cluster: Q9Y343 1 Blocks protein family: IPB001683 Phox-like
UniProtKB/Swiss-Prot: SNX24_HUMAN, Q9Y343Domain: The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3))(By similarity)Similarity: Belongs to the sorting nexin familySimilarity: Contains 1 PX (phox homology) domain |
Function
for SNX24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNX24_HUMAN, Q9Y343Function: May be involved in several stages of intracellular trafficking (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX24 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX24
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: SNX24 (NM_014035) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX24 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX24 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX24 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035091 | phosphatidylinositol binding |
IEA | -- |
SNX24 for ontologies About GeneDecksing
|
Pathways & Interactions
for SNX24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX24
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for SNX24 (Q9Y3432, 3 ENSP000002613694) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007154 | cell communication |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- |
SNX24 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNX24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNX24
Search CenterWatch for drugs/clinical trials and news about SNX24
|
Transcripts
for SNX24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNX24 gene: NM_014035.2 Unigene Cluster for SNX24: Sorting nexin 24 Hs.483200 [show with all ESTs]Unigene Representative Sequence: NM_01403512 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000513613 ENST00000511211 ENST00000261369(uc011cwo.2 uc010jcy.3)
ENST00000513881(uc003ktf.2) ENST00000395451 ENST00000506996 ENST00000511545
ENST00000502387 ENST00000503149 ENST00000510914 ENST00000507364 ENST00000515729
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX24 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX24
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNX24 (NM_014035) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX24 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX24 |
Additional cDNA sequence: AF139461.1 AK021473.1 AY044655.1 AY358098.1 BC010886.1 BC069012.1 14 DOTS entries: DT.456325 DT.91979118 DT.95168256 DT.40248101 DT.91745275 DT.102830306 DT.120890420 DT.95148531 DT.120890358 DT.91851992 DT.95168253 DT.97841434 DT.99929243 DT.40195050 24/157 AceView cDNA sequences (see all 157): BU166663 BQ672581 BM504864 AI797394 BI818751 BQ641298 AI768861 AA854965 H62436 AI423264 AW594082 AA113247 AI272805 BE673672 BE220115 BM504540 BX379592 BG481515 AW001739 AI744578 BC010886 AY044655 AI282126 BI493587
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SNX24 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SNX24
|
Expression
for SNX24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SNX24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX24
SOURCE GeneReport for Unigene cluster: Hs.483200
SABiosciences Custom PCR Arrays for SNX24
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX24
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX24 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX24 |
Orthologs
for SNX24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNX24 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for SNX24 (if available)
TreeFam Gene Tree for SNX24 (if available) |
Paralogs
for SNX24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNX24 gene
- SNX222
3 SIMAP similar genes for SNX24 using alignment to 4 protein entries: SNX24_HUMAN (see all proteins):SNX22 SGK3 SNX17
SNX24 for paralogs About GeneDecksing
|
Genomic Variants
for SNX24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX24 (122179134 - 122365049 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for SNX24
1 CNV: 99284
6 Indels: 12750 46764 27787 42582 12749 62427 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX24 |
|
Disorders
/ Diseases
for SNX24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SNX24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX24 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SNX24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Sorting out the cellular functions of sorting nexins. (PubMed id 12461558)1, 3 Worby C.A. and Dixon J.E. (2002)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SNX24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNX24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX24 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNX24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNX24 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX24 gene:
Search GeneIP for patents involving SNX24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNX24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SNX24 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX24 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX24 | | | OriGene Protein Over-expression Lysate for SNX24 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SNX24 | | OriGene 3'-UTR Clone for SNX24 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX24 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX24 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX24 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX24 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX24 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX24 |
| |
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| | | | Search Tocris compounds for SNX24 |
| |  |  |  |  | | | | |
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 |
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 | | | SNX24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX24 |
|  |  |  | | | | Search ThermoFisher Antibodies for SNX24 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX24 |
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