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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNX24 Gene

protein-coding   GIFtS: 45
GCID: GC05P122209

Sorting Nexin 24

  Search for SNX24
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sorting Nexin 241 2
PRO12842
Sorting Nexin-242
Sorting Nexing 242

External Ids:    HGNC: 215331   Entrez Gene: 289662   Ensembl: ENSG000000646527   UniProtKB: Q9Y3433   

Export aliases for SNX24 gene to outside databases

Previous GC identifers: GC05P122508 GC05P122212 GC05P122257 GC05P117368


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SNX24 Gene: 
SNX24 (sorting nexin 24) is a protein-coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX22.

UniProtKB/Swiss-Prot: SNX24_HUMAN, Q9Y343
Function: May be involved in several stages of intracellular trafficking (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNX24 gene promoter:
         STAT5B   STAT1   STAT2   STAT4   STAT6   STAT3   STAT1beta   STAT5A   Cdc5   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNX24 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNX24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2   Ensembl cytogenetic band:  5q23.2   HGNC cytogenetic band: 5q23.2

SNX24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX24 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P122209:  view genomic region     (about GC identifiers)

Start:
122,179,134 bp from pter      End:
122,365,049 bp from pter
Size:
185,916 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNX24_HUMAN, Q9Y343 (See protein sequence)
Recommended Name: Sorting nexin-24  
Size: 169 amino acids; 19818 Da
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity)
1 PDB 3D structure from and Proteopedia for SNX24:
4AZ9 (3D)    
Secondary accessions: Q6UY33
Alternative splicing: 2 isoforms:  Q9Y343-1   Q9Y343-2   

Explore the universe of human proteins at neXtProt for SNX24: NX_Q9Y343

Explore proteomics data for SNX24 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y343

  • SNX24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNX24 Protein Expression
    REFSEQ proteins: NP_054754.1  
    ENSEMBL proteins: 
     ENSP00000261369   ENSP00000424149   ENSP00000378837   ENSP00000422535   ENSP00000422184  
     ENSP00000425919  

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    Cloud-Clone Corp. Proteins for SNX24 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030659cytoplasmic vesicle membrane IEA--

    SNX24 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SNX: Sorting nexins

    1 InterPro protein domain:
     IPR001683 Phox

    Graphical View of Domain Structure for InterPro Entry Q9Y343

    ProtoNet protein and cluster: Q9Y343

    1 Blocks protein domain: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SNX24_HUMAN, Q9Y343
    Domain: The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate
    (PtdIns(P3)) (By similarity)
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain


    SNX24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNX24_HUMAN, Q9Y343
    Function: May be involved in several stages of intracellular trafficking (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0035091phosphatidylinositol binding IEA--
         
    SNX24 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX24

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for SNX24 (Q9Y3432, 3 ENSP000002613694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-8271905 I2D: score=2 STRING: ENSP00000309503
    SH3GL3Q999632, 3, ENSP000003913724MINT-65814 I2D: score=4 STRING: ENSP00000391372
    --P310162MINT-8107333
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007154cell communication IEA--
    GO:0015031protein transport IEA--

    SNX24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNX24

    Search CenterWatch for drugs/clinical trials and news about SNX24

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNX24 gene: 
    NM_014035.2  

    Unigene Cluster for SNX24:

    Sorting nexin 24
    Hs.483200  [show with all ESTs]
    Unigene Representative Sequence: NM_014035
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513613 ENST00000511211 ENST00000261369(uc011cwo.2 uc010jcy.3)
    ENST00000513881(uc003ktf.2) ENST00000395451 ENST00000506996 ENST00000511545
    ENST00000502387 ENST00000503149 ENST00000510914 ENST00000507364 ENST00000515729

    miRNA
    Products:
         
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX24 (see all 22):
    hsa-miR-4251 hsa-miR-539 hsa-miR-4328 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-138-2* hsa-miR-183*
    SwitchGear 3'UTR luciferase reporter plasmidSNX24 3' UTR sequence
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    Additional mRNA sequence: 

    AF139461.1 AK021473.1 AY044655.1 AY358098.1 BC010886.1 BC069012.1 

    14 DOTS entries:

    DT.456325  DT.91979118  DT.95168256  DT.40248101  DT.91745275  DT.102830306  DT.120890420  DT.95148531 
    DT.120890358  DT.91851992  DT.95168253  DT.97841434  DT.99929243  DT.40195050 

    24/157 AceView cDNA sequences (see all 157):

    AI797394 AA854965 AI768861 H62436 BI818751 BQ641298 BE673672 AI423264 
    AA113247 AW594082 AI272805 BX379592 BM504540 BG481515 BC010886 BE220115 
    AI282126 AI744578 AW001739 AY044655 AW137955 BI493587 BM702756 AI418240 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SNX24    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
    SP1:                    -                                         -         
    SP2:                    -                                                   
    SP3:        -     -     -                                                   
    SP4:                                                                        


    ECgene alternative splicing isoforms for SNX24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNX24 expression in normal human tissues (normalized intensities)      SNX24 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SNX24 Expression
    About this image


    SNX24 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
     
     Esophagus (Gastrointestinal Tract)

    See SNX24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNX24

    SOURCE GeneReport for Unigene cluster: Hs.483200
        SABiosciences Custom PCR Arrays for SNX24
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SNX24 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snx241 , 5 sorting nexing 241, 5 89.74(n)1
    97.04(a)1
      18 (29.00 cM)5
    692261  NM_029394.31  NP_083670.11 
     532456625 
    chicken
    (Gallus gallus)
    Aves SNX241 sorting nexin 24 84.81(n)
    92.9(a)
      426798  NM_001101649.1  NP_001095119.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNX246
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343193.1(12206862-12285820)
    zebrafish
    (Danio rerio)
    Actinopterygii snx241 sorting nexin 24 73.02(n)
    77.98(a)
      619249  NM_001033731.1  NP_001028903.1 


    ENSEMBL Gene Tree for SNX24 (if available)
    TreeFam Gene Tree for SNX24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNX24 gene
    SNX222  
    3 SIMAP similar genes for SNX24 using alignment to 4 protein entries:     SNX24_HUMAN (see all proteins):
    SNX22    SGK3    SNX17

    SNX24 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3210 SNPs in SNX24 are shown (see all 3210)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868733431,2
    --122179191(+) GTATAC/TATTTT 1 -- us2k10--------
    rs171497061,2
    C,F,H--122179193(+) ATACAT/CTTTCA 1 -- us2k18Minor allele frequency- C:0.01NA NS EA WA 678
    rs100449211,2
    C,F,A,H--122179357(+) GGCTAG/CTAACA 1 -- us2k116Minor allele frequency- C:0.14NS EA NA WA CSA 787
    rs1475796361,2
    C--122179678(+) ACAGGA/GTTTCA 1 -- us2k10--------
    rs1417869911,2
    --122179687(+) CATCAC/TGTTGG 1 -- us2k10--------
    rs1470822461,2
    C--122179708(+) CTCAAA/GCTCTT 1 -- us2k10--------
    rs1919565941,2
    --122179719(+) GACTTA/CAGGTG 1 -- us2k10--------
    rs1481792891,2
    --122179738(+) ACCTCC/GGCCTC 1 -- us2k10--------
    rs1836912091,2
    --122179786(+) CGGCCA/GTGTGA 1 -- us2k10--------
    rs1890903241,2
    --122179817(+) GACATC/TATGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNX24 (122179134 - 122365049 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SNX24:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2095337CNV Deletion18987734
    esv1686062CNV Deletion17803354
    esv2730709CNV Deletion23290073
    esv2730708CNV Deletion23290073
    esv4604CNV Deletion18987735
    esv2569438CNV Deletion19546169
    esv1008444CNV Deletion20482838
    dgv213n6CNV Loss16902084
    esv5852CNV Loss19470904
    nsv830471CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SNX24 for disorders           About MalaCards

    SNX24 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SNX24

    Export disorders for SNX24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNX24 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with SNX24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Sorting out the cellular functions of sorting nexins. (PubMed id 12461558)1, 3 Worby C.A. and Dixon J.E. (2002)
    4. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    5. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    9. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28966 HGNC: 21533 AceView: SNX24 Ensembl:ENSG00000064652 euGenes: HUgn28966
    ECgene: SNX24 H-InvDB: SNX24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNX24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNX24 gene:
    Search GeneIP for patents involving SNX24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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