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Aliases for SNX22 Gene

Subcategory (RNA class) for SNX22 Gene


Aliases for SNX22 Gene

  • Sorting Nexin 22 2 3

External Ids for SNX22 Gene

ORGUL Members for SNX22 Gene

Previous GeneCards Identifiers for SNX22 Gene

  • GC15P057603
  • GC15P062022
  • GC15P062159
  • GC15P062230
  • GC15P064443
  • GC15P041268

Summaries for SNX22 Gene

Entrez Gene Summary for SNX22 Gene

  • The protein encoded by this gene is a sorting nexin that is found in the cytoplasm, where it interacts with membrane-bound phosphatidylinositol 3-phosphate. The encoded protein may play a role in intracellular trafficking. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for SNX22 Gene

SNX22 (Sorting Nexin 22) is a Protein Coding gene, and is affiliated with the antisense RNA class. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX24.

UniProtKB/Swiss-Prot for SNX22 Gene

  • May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX22 Gene

Genomics for SNX22 Gene

Regulatory Elements for SNX22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNX22 Gene

64,151,700 bp from pter
64,157,481 bp from pter
5,782 bases
Plus strand

Genomic View for SNX22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX22 Gene

Proteins for SNX22 Gene

  • Protein details for SNX22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-22
    Protein Accession:
    Secondary Accessions:
    • Q8WUS9
    • Q9H844

    Protein attributes for SNX22 Gene

    193 amino acids
    Molecular mass:
    22068 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SNX22 Gene

    Alternative splice isoforms for SNX22 Gene


neXtProt entry for SNX22 Gene

Proteomics data for SNX22 Gene at MOPED

Post-translational modifications for SNX22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNX22 Gene

Domains for SNX22 Gene

Gene Families for SNX22 Gene

  • SNX :Sorting nexins

Protein Domains for SNX22 Gene


Suggested Antigen Peptide Sequences for SNX22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96L94
  • The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
  • Contains 1 PX (phox homology) domain.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX22: view

Function for SNX22 Gene

Molecular function for SNX22 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

Gene Ontology (GO) - Molecular Function for SNX22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX22: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SNX22 Gene

Localization for SNX22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX22 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for SNX22 Gene COMPARTMENTS Subcellular localization image for SNX22 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SNX22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with SNX22: view

Pathways for SNX22 Gene

SuperPathways for SNX22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SNX22: view

No data available for Pathways by source for SNX22 Gene

Transcripts for SNX22 Gene

Unigene Clusters for SNX22 Gene

Sorting nexin 22:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX22

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX22 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -

Relevant External Links for SNX22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX22 Gene

mRNA expression in normal human tissues for SNX22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNX22 Gene

This gene is overexpressed in Thyroid (10.7) and Brain - Spinal cord (cervical c-1) (5.0).

Protein differential expression in normal tissues for SNX22 Gene

This gene is overexpressed in Prostate (41.5) and Blymphocyte (27.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SNX22 Gene

SOURCE GeneReport for Unigene cluster for SNX22 Gene Hs.744250

genes like me logo Genes that share expressions with SNX22: view

Expression partners for SNX22 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SNX22 Gene

Orthologs for SNX22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNX22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SNX22 35
  • 86.71 (n)
  • 82.08 (a)
SNX22 36
  • 82 (a)
(Canis familiaris)
Mammalia SNX22 35
  • 86.49 (n)
  • 81.58 (a)
SNX22 36
  • 82 (a)
(Mus musculus)
Mammalia Snx22 35
  • 85.82 (n)
  • 84.57 (a)
Snx22 16
Snx22 36
  • 83 (a)
(Pan troglodytes)
Mammalia SNX22 35
  • 99.65 (n)
  • 99.48 (a)
SNX22 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Snx22 35
  • 89.49 (n)
  • 90 (a)
(Monodelphis domestica)
Mammalia SNX22 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia SNX22 36
  • 62 (a)
(Gallus gallus)
Aves SNX22 35
  • 70.02 (n)
  • 57.86 (a)
SNX22 36
  • 50 (a)
(Anolis carolinensis)
Reptilia SNX22 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx22 35
  • 59.24 (n)
  • 55.42 (a)
(Danio rerio)
Actinopterygii snx22 35
  • 51.79 (n)
  • 48.39 (a)
snx22 36
  • 36 (a)
Species with no ortholog for SNX22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX22 Gene

Gene Tree for SNX22 (if available)
Gene Tree for SNX22 (if available)

Paralogs for SNX22 Gene

Paralogs for SNX22 Gene

Selected SIMAP similar genes for SNX22 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SNX22: view

Variants for SNX22 Gene

Sequence variations from dbSNP and Humsavar for SNX22 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs895883 -- 64,154,714(+) CAACA(C/G)GCAAG utr-variant-3-prime, nc-transcript-variant
rs895885 -- 64,154,773(+) TGGCT(C/G)ATGCC utr-variant-3-prime, nc-transcript-variant
rs1972982 -- 64,155,239(+) attac(A/G)agagt utr-variant-3-prime, nc-transcript-variant
rs1972984 -- 64,155,242(+) acaag(A/C)gtgag utr-variant-3-prime, nc-transcript-variant
rs3985675 -- 64,151,632(-) CGCCC(-/CG)NGGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNX22 Gene

Variant ID Type Subtype PubMed ID
nsv833036 CNV Loss 17160897
nsv827360 CNV Loss 20364138

Relevant External Links for SNX22 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX22 Gene

Disorders for SNX22 Gene

No disorders were found for SNX22 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SNX22 Gene

Publications for SNX22 Gene

  1. Solution structure of human sorting nexin 22. (PMID: 17400918) Song J. … Markley J.L. (Protein Sci. 2007) 2 3 4 23
  2. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby C.A. … Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3

Products for SNX22 Gene

Sources for SNX22 Gene

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