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Aliases for SNX22 Gene

Subcategory (RNA class) for SNX22 Gene


Aliases for SNX22 Gene

  • Sorting Nexin 22 2 3 5

External Ids for SNX22 Gene

ORGUL Members for SNX22 Gene

Previous GeneCards Identifiers for SNX22 Gene

  • GC15P057603
  • GC15P062022
  • GC15P062159
  • GC15P062230
  • GC15P064443
  • GC15P041268

Summaries for SNX22 Gene

Entrez Gene Summary for SNX22 Gene

  • The protein encoded by this gene is a sorting nexin that is found in the cytoplasm, where it interacts with membrane-bound phosphatidylinositol 3-phosphate. The encoded protein may play a role in intracellular trafficking. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for SNX22 Gene

SNX22 (Sorting Nexin 22) is a Protein Coding gene, and is affiliated with the antisense RNA class. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX24.

UniProtKB/Swiss-Prot for SNX22 Gene

  • May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX22 Gene

Genomics for SNX22 Gene

Regulatory Elements for SNX22 Gene

Enhancers for SNX22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNX22 on UCSC Golden Path with GeneCards custom track

Promoters for SNX22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNX22 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX22 Gene

64,151,698 bp from pter
64,157,481 bp from pter
5,784 bases
Plus strand

Genomic View for SNX22 Gene

Genes around SNX22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX22 Gene

Proteins for SNX22 Gene

  • Protein details for SNX22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-22
    Protein Accession:
    Secondary Accessions:
    • Q8WUS9
    • Q9H844

    Protein attributes for SNX22 Gene

    193 amino acids
    Molecular mass:
    22068 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SNX22 Gene

    Alternative splice isoforms for SNX22 Gene


neXtProt entry for SNX22 Gene

Proteomics data for SNX22 Gene at MOPED

Post-translational modifications for SNX22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNX22 Gene

Domains & Families for SNX22 Gene

Gene Families for SNX22 Gene

Protein Domains for SNX22 Gene


Suggested Antigen Peptide Sequences for SNX22 Gene

Graphical View of Domain Structure for InterPro Entry



  • The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
  • Belongs to the sorting nexin family.
  • The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
  • Contains 1 PX (phox homology) domain.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX22: view

Function for SNX22 Gene

Molecular function for SNX22 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
genes like me logo Genes that share phenotypes with SNX22: view

Animal Models for SNX22 Gene

MGI Knock Outs for SNX22:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNX22 Gene

Localization for SNX22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX22 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for SNX22 Gene COMPARTMENTS Subcellular localization image for SNX22 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SNX22 Gene

Pathways & Interactions for SNX22 Gene

SuperPathways for SNX22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX22 Gene


No data available for Pathways by source and SIGNOR curated interactions for SNX22 Gene

Drugs & Compounds for SNX22 Gene

No Compound Related Data Available

Transcripts for SNX22 Gene

Unigene Clusters for SNX22 Gene

Sorting nexin 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX22 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -

Relevant External Links for SNX22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX22 Gene

mRNA expression in normal human tissues for SNX22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNX22 Gene

This gene is overexpressed in Thyroid (x10.7) and Brain - Spinal cord (cervical c-1) (x5.0).

Protein differential expression in normal tissues from HIPED for SNX22 Gene

This gene is overexpressed in Prostate (41.5) and Blymphocyte (27.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNX22 Gene

SOURCE GeneReport for Unigene cluster for SNX22 Gene Hs.744250

genes like me logo Genes that share expression patterns with SNX22: view

Protein tissue co-expression partners for SNX22 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SNX22 Gene

Orthologs for SNX22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNX22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SNX22 35
  • 86.71 (n)
  • 82.08 (a)
SNX22 36
  • 82 (a)
(Canis familiaris)
Mammalia SNX22 35
  • 86.49 (n)
  • 81.58 (a)
SNX22 36
  • 82 (a)
(Mus musculus)
Mammalia Snx22 35
  • 85.82 (n)
  • 84.57 (a)
Snx22 16
Snx22 36
  • 83 (a)
(Pan troglodytes)
Mammalia SNX22 35
  • 99.65 (n)
  • 99.48 (a)
SNX22 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Snx22 35
  • 89.49 (n)
  • 90 (a)
(Monodelphis domestica)
Mammalia SNX22 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia SNX22 36
  • 62 (a)
(Gallus gallus)
Aves SNX22 35
  • 70.02 (n)
  • 57.86 (a)
SNX22 36
  • 50 (a)
(Anolis carolinensis)
Reptilia SNX22 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx22 35
  • 59.24 (n)
  • 55.42 (a)
(Danio rerio)
Actinopterygii snx22 35
  • 51.79 (n)
  • 48.39 (a)
snx22 36
  • 36 (a)
Species with no ortholog for SNX22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX22 Gene

Gene Tree for SNX22 (if available)
Gene Tree for SNX22 (if available)

Paralogs for SNX22 Gene

Paralogs for SNX22 Gene

(1) SIMAP similar genes for SNX22 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SNX22: view

Variants for SNX22 Gene

Sequence variations from dbSNP and Humsavar for SNX22 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs895885 -- 64,154,773(+) TGGCT(C/G)ATGCC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs12441671 -- 64,152,971(+) ACCCA(C/G/T)GTCCT intron-variant
rs7173414 -- 64,153,591(+) TCTCC(A/C)CCCCT intron-variant
rs1972984 -- 64,155,242(+) acaag(A/C)gtgag nc-transcript-variant, utr-variant-3-prime
rs12917230 -- 64,155,148(+) taata(A/G)agatg nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SNX22 Gene

Variant ID Type Subtype PubMed ID
nsv833036 CNV Loss 17160897
nsv827360 CNV Loss 20364138

Variation tolerance for SNX22 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SNX22 Gene

Disorders for SNX22 Gene

Relevant External Links for SNX22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SNX22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX22 Gene

Publications for SNX22 Gene

  1. Solution structure of human sorting nexin 22. (PMID: 17400918) Song J. … Markley J.L. (Protein Sci. 2007) 2 3 4 23 67
  2. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby C.A. … Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002) 2 3
  3. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A. … Verhasselt B. (Retrovirology 2014) 3
  4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for SNX22 Gene

Sources for SNX22 Gene