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Aliases for SNX22 Gene

Subcategory (RNA class) for SNX22 Gene

antisense

Aliases for SNX22 Gene

  • Sorting Nexin 22 2 3 5

External Ids for SNX22 Gene

ORGUL Members for SNX22 Gene

Previous GeneCards Identifiers for SNX22 Gene

  • GC15P057603
  • GC15P062022
  • GC15P062159
  • GC15P062230
  • GC15P064443
  • GC15P041268

Summaries for SNX22 Gene

Entrez Gene Summary for SNX22 Gene

  • The protein encoded by this gene is a sorting nexin that is found in the cytoplasm, where it interacts with membrane-bound phosphatidylinositol 3-phosphate. The encoded protein may play a role in intracellular trafficking. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for SNX22 Gene

SNX22 (Sorting Nexin 22) is a Protein Coding gene, and is affiliated with the antisense RNA class. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX24.

UniProtKB/Swiss-Prot for SNX22 Gene

  • May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

Additional gene information for SNX22 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX22 Gene

Genomics for SNX22 Gene

GeneHancer (GH) Regulatory Elements for SNX22 Gene

Promoters and enhancers for SNX22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I064150 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 568.6 +1.2 1165 3.9 HDGF ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 E2F8 ZNF207 ZNF143 SNX22 TRIP4 CSNK1G1 GC15M064162 GC15M064164
GH15I064149 Enhancer 1.1 Ensembl ENCODE dbSUPER 550.8 -1.6 -1561 1.1 HDAC1 BCOR CTCF PKNOX1 ZMYM3 RAD21 FOXK2 ZNF143 PRDM10 SMARCA5 SNX22 PIR38042
GH15I064092 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.1 -56.3 -56272 6.5 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D SNX1 FAM96A TRIP4 CSNK1G1 USP3 ENSG00000264937 USP3-AS1 SNX22 ZNF609 ENSG00000259635
GH15I064069 Enhancer 1.4 Ensembl ENCODE dbSUPER 18.4 -80.3 -80265 4.1 FOXA2 MLX ARID4B YY1 SLC30A9 ZNF766 ZNF143 FOS SP5 REST DAPK2 TRIP4 ZNF609 SNX1 ENSG00000264937 FAM96A SNX22 ENSG00000265967 HERC1 USP3
GH15I064246 Enhancer 1.6 FANTOM5 Ensembl ENCODE 10.3 +96.8 96829 4.5 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 TRIP4 CSNK1G1 PPIB ENSG00000252774 ENSG00000265967 RNU6-549P SNX22 HERC1 RBPMS2 ZNF609
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNX22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNX22 gene promoter:

Genomic Locations for SNX22 Gene

Genomic Locations for SNX22 Gene
chr15:64,151,698-64,157,481
(GRCh38/hg38)
Size:
5,784 bases
Orientation:
Plus strand
chr15:64,443,914-64,449,680
(GRCh37/hg19)

Genomic View for SNX22 Gene

Genes around SNX22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX22 Gene

Proteins for SNX22 Gene

  • Protein details for SNX22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L94-SNX22_HUMAN
    Recommended name:
    Sorting nexin-22
    Protein Accession:
    Q96L94
    Secondary Accessions:
    • Q8WUS9
    • Q9H844

    Protein attributes for SNX22 Gene

    Size:
    193 amino acids
    Molecular mass:
    22068 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SNX22 Gene

    Alternative splice isoforms for SNX22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX22 Gene

Post-translational modifications for SNX22 Gene

No Post-translational modifications

Other Protein References for SNX22 Gene

No data available for DME Specific Peptides for SNX22 Gene

Domains & Families for SNX22 Gene

Gene Families for SNX22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNX22 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX22 Gene

Graphical View of Domain Structure for InterPro Entry

Q96L94

UniProtKB/Swiss-Prot:

SNX22_HUMAN :
  • The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX22: view

Function for SNX22 Gene

Molecular function for SNX22 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

Gene Ontology (GO) - Molecular Function for SNX22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX22: view
genes like me logo Genes that share phenotypes with SNX22: view

Animal Models for SNX22 Gene

MGI Knock Outs for SNX22:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNX22 Gene

Localization for SNX22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX22 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX22 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNX22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SNX22: view

Pathways & Interactions for SNX22 Gene

SuperPathways for SNX22 Gene

No Data Available

Interacting Proteins for SNX22 Gene

Gene Ontology (GO) - Biological Process for SNX22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SNX22: view

No data available for Pathways by source and SIGNOR curated interactions for SNX22 Gene

Drugs & Compounds for SNX22 Gene

No Compound Related Data Available

Transcripts for SNX22 Gene

Unigene Clusters for SNX22 Gene

Sorting nexin 22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX22 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for SNX22 Gene

GeneLoc Exon Structure for
SNX22
ECgene alternative splicing isoforms for
SNX22

Expression for SNX22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNX22 Gene

This gene is overexpressed in Thyroid (x10.7) and Brain - Spinal cord (cervical c-1) (x5.0).

Protein differential expression in normal tissues from HIPED for SNX22 Gene

This gene is overexpressed in Prostate (41.5) and Blymphocyte (27.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNX22 Gene



Protein tissue co-expression partners for SNX22 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNX22 Gene:

SNX22

SOURCE GeneReport for Unigene cluster for SNX22 Gene:

Hs.744250

Evidence on tissue expression from TISSUES for SNX22 Gene

  • Intestine(4.5)
  • Nervous system(4.5)
  • Spleen(2.2)
  • Liver(2.1)
  • Lung(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with SNX22: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX22 Gene

Orthologs for SNX22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNX22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX22 33 34
  • 99.65 (n)
rat
(Rattus norvegicus)
Mammalia Snx22 33
  • 89.49 (n)
cow
(Bos Taurus)
Mammalia SNX22 33 34
  • 86.71 (n)
dog
(Canis familiaris)
Mammalia SNX22 33 34
  • 86.49 (n)
mouse
(Mus musculus)
Mammalia Snx22 33 16 34
  • 85.82 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX22 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX22 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX22 33 34
  • 70.02 (n)
lizard
(Anolis carolinensis)
Reptilia SNX22 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx22 33
  • 59.24 (n)
zebrafish
(Danio rerio)
Actinopterygii snx22 33 34
  • 51.79 (n)
Species where no ortholog for SNX22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX22 Gene

ENSEMBL:
Gene Tree for SNX22 (if available)
TreeFam:
Gene Tree for SNX22 (if available)

Paralogs for SNX22 Gene

Paralogs for SNX22 Gene

(1) SIMAP similar genes for SNX22 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SNX22: view

Variants for SNX22 Gene

Sequence variations from dbSNP and Humsavar for SNX22 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs113626158 uncertain-significance, Osteogenesis Imperfecta, Recessive 64,155,833(+) A/C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs121434559 pathogenic, not-provided, Osteogenesis imperfecta type 9, not provided 64,156,802(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs137853869 pathogenic, not-provided, Osteogenesis imperfecta type 9, not provided 64,156,115(+) TCTT/ 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs202080377 likely-benign, Osteogenesis Imperfecta, Recessive 64,155,819(+) TT/TTT 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs369889089 uncertain-significance, Osteogenesis Imperfecta, Recessive 64,156,077(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNX22 Gene

Variant ID Type Subtype PubMed ID
nsv827360 CNV loss 20364138
nsv833036 CNV loss 17160897

Variation tolerance for SNX22 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNX22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX22 Gene

Disorders for SNX22 Gene

Additional Disease Information for SNX22

No disorders were found for SNX22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX22 Gene

Publications for SNX22 Gene

  1. Solution structure of human sorting nexin 22. (PMID: 17400918) Song J … Markley JL (Protein science : a publication of the Protein Society 2007) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby CA … Dixon JE (Nature reviews. Molecular cell biology 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A … Verhasselt B (Retrovirology 2014) 3 58

Products for SNX22 Gene

Sources for SNX22 Gene

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