SNX22 Gene
protein-coding GIFtS: 44
GCID: GC15P064443
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|
sorting nexin 22
| |
Aliases
for SNX22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sorting Nexin 221 2 | | FLJ139521 | | Sorting Nexin-222 |
Export aliases for SNX22 gene to outside databasesPrevious GC identifers: GC15P057603 GC15P062022 GC15P062159 GC15P062230 GC15P041268 |
Summaries
for SNX22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNX22:
The protein encoded by this gene is a sorting nexin that is found in the cytoplasm, where it interacts withmembrane-bound phosphatidylinositol 3-phosphate. The encoded protein may play a role in intracellular trafficking. Twotranscript variants, one protein-coding and the other not protein-coding, have been found for this gene. (provided byRefSeq, Dec 2012)
UniProtKB/Swiss-Prot: SNX22_HUMAN, Q96L94Function: May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranescontaining phosphatidylinositol 3-phosphate (PtdIns(3P))
|
Genomic Views
for SNX22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNX22 gene promoter:
USF1 SREBP-1c C/EBPalpha E47 SREBP-1b GATA-2 Arnt SREBP-1a USF-1 Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22.31 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q22.1SNX22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P064443: view genomic region
(about GC identifiers)
Start:
|
64,443,914 bp from pter |
End:
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64,449,680 bp from pter |
Size:
|
5,767 bases |
Orientation:
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plus strand |
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Proteins
for SNX22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNX22_HUMAN, Q96L94 (See
protein sequence)Recommended Name: Sorting nexin-22 Size: 193 amino acids; 22068 Da
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity)
1 PDB 3D structure from  and Proteopedia  for SNX22:2ETT (3D)
Secondary accessions: Q9H844Explore the universe of human proteins at neXtProt for SNX22: NX_Q96L94
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96L94
SNX22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079074.2
ENSEMBL proteins: ENSP00000323435 ENSP00000452692
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030659 | cytoplasmic vesicle membrane |
IEA | -- |
SNX22 for ontologies About GeneDecksing
SNX22 Antibody Products:
Assay Products for SNX22: |
Protein
Domains /
Families
for SNX22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX22 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96L94ProtoNet protein and cluster: Q96L94 1 Blocks protein family: IPB001683 Phox-like
UniProtKB/Swiss-Prot: SNX22_HUMAN, Q96L94Domain: The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3))Similarity: Belongs to the sorting nexin familySimilarity: Contains 1 PX (phox homology) domain |
Function
for SNX22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNX22_HUMAN, Q96L94Function: May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranescontaining phosphatidylinositol 3-phosphate (PtdIns(3P))
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX22 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035091 | phosphatidylinositol binding |
IEA | -- |
SNX22 for ontologies About GeneDecksing
|
Pathways & Interactions
for SNX22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX22
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for SNX22 (Q96L942, 3 ENSP000003234354) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007154 | cell communication |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- |
SNX22 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNX22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNX22
Search CenterWatch for drugs/clinical trials and news about SNX22
|
Transcripts
for SNX22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNX22 gene: NM_024798.2 Unigene Cluster for SNX22: Sorting nexin 22 Hs.744250 [show with all ESTs]Unigene Representative Sequence: NR_0735347 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000557789(uc002amz.1) ENST00000325881(uc002anc.1) ENST00000561334(uc002ana.1)
ENST00000558466(uc002anb.1) ENST00000560607 ENST00000560945 ENST00000560997
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX22 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX22
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNX22 (NM_024798) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX22 |
Additional cDNA sequence: AK024014.1 AL832838.1 AY044653.1 BC014660.1 BC019655.1 BC030225.1 NR_073534.1 9 DOTS entries: DT.101985571 DT.40130282 DT.95315175 DT.97836553 DT.95154427 DT.95158055 DT.95344633 DT.100845917 DT.95154428 24/77 AceView cDNA sequences (see all 77): AI671317 AI242191 D81932 BC019655 AI968213 AI968104 AY044653 AI939497 BE671765 BU071191 BC030225 BC014660 BE045919 AI632509 AW025702 BX104306 R11214 AI339451 BQ066597 AU142897 AI918684 AI911331 BF932623 BV197378
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SNX22 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
|---|
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SNX22
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Expression
for SNX22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SNX22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX22
SOURCE GeneReport for Unigene cluster: Hs.744250
SABiosciences Custom PCR Arrays for SNX22
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX22 |
Orthologs
for SNX22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNX22 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for SNX22 (if available)
TreeFam Gene Tree for SNX22 (if available) |
Paralogs
for SNX22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNX22 gene
- SNX242
1 SIMAP similar gene for SNX22 using alignment to 3 protein entries: SNX22_HUMAN (see all proteins):SNX24
SNX22 for paralogs About GeneDecksing
|
Genomic Variants
for SNX22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX22 (64443914 - 64449680 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNX22: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX22 |
|
Disorders
/ Diseases
for SNX22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SNX22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SNX22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Solution structure of human sorting nexin 22. (PubMed id 17400918)1, 2, 3, 9 Song J....Markley J.L. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Sorting out the cellular functions of sorting nexins. (PubMed id 12461558)1, 3 Worby C.A. and Dixon J.E. (2002)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for SNX22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNX22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNX22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNX22 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX22 gene:
Search GeneIP for patents involving SNX22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNX22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX22 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX22 |
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| |  |  |  |  | | | | |
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 | | | SNX22 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX22 |
|  |  |  | | | | Search ThermoFisher Antibodies for SNX22 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX22 |
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