SNX21 Gene
protein-coding GIFtS: 45
GCID: GC20P044462
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|
sorting nexin family member 21(Previous name: chromosome 20 open reading frame 161 )
(Previous symbol: C20orf161)
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Aliases
for SNX21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sorting Nexin Family Member 211 2 | | Chromosome 20 Open Reading Frame 1611 | | C20orf1611 2 3 | | PP39932 | | SNX-L1 2 3 | | Sorting Nexin 212 | | DJ337O18.41 | | Sorting Nexin-212 | | Sorting Nexin L2 3 | | SNXL3 |
Export aliases for SNX21 gene to outside databasesPrevious GC identifers: GC20P043896 GC20P041204 |
Summaries
for SNX21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNX21:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiledcoil region, like some family members. The specific function of this protein has not been determined. Multipletranscript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SNX21_HUMAN, Q969T3Function: May be involved in several stages of intracellular trafficking (By similarity)
Gene Wiki entry for SNX21
|
Genomic Views
for SNX21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNX21 gene promoter:
Egr-3 Max1 AhR MyoD Lmo2 Arnt Egr-2 HFH-1 Msx-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12SNX21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P044462: view genomic region
(about GC identifiers)
Start:
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44,462,449 bp from pter |
End:
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44,471,914 bp from pter |
Size:
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9,466 bases |
Orientation:
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plus strand |
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Proteins
for SNX21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNX21_HUMAN, Q969T3 (See
protein sequence)Recommended Name: Sorting nexin-21 Size: 373 amino acids; 41365 Da
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity)
Secondary accessions: Q5JZH5 Q5JZH6 Q8WUR6 Q9BR16Alternative splicing: 2 isoforms: Q969T3-1 Q969T3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SNX21: NX_Q969T3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969T3
SNX21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001036097.1 NP_001036098.1 NP_219489.1 NP_690857.1
ENSEMBL proteins: ENSP00000420169 ENSP00000418593 ENSP00000344586 ENSP00000361620 ENSP00000361619
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030659 | cytoplasmic vesicle membrane |
IEA | -- |
SNX21 for ontologies About GeneDecksing
SNX21 Antibody Products:
Assay Products for SNX21: |
Protein
Domains /
Families
for SNX21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX21 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q969T3ProtoNet protein and cluster: Q969T3 1 Blocks protein family: IPB001683 Phox-like
UniProtKB/Swiss-Prot: SNX21_HUMAN, Q969T3Domain: The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3))(By similarity)Similarity: Belongs to the sorting nexin familySimilarity: Contains 1 PX (phox homology) domain |
Function
for SNX21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNX21_HUMAN, Q969T3Function: May be involved in several stages of intracellular trafficking (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX21 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX21 (see all 4)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX21 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035091 | phosphatidylinositol binding |
IEA | -- |
SNX21 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SNX21:
|
Pathways & Interactions
for SNX21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX21
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SNX21 (ENSP000004185934) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007154 | cell communication |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- |
SNX21 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNX21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNX21
Search CenterWatch for drugs/clinical trials and news about SNX21
|
Transcripts
for SNX21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNX21 gene (4 alternative transcripts): NM_001042632.1 NM_001042633.1 NM_033421.2 NM_152897.1 Unigene Cluster for SNX21: Sorting nexin family member 21 Hs.472854 [show with all ESTs]Unigene Representative Sequence: NM_00104263312 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000466252 ENST00000462307 ENST00000472219 ENST00000491381 ENST00000342644
ENST00000372542 ENST00000372541 ENST00000344780(uc002xpt.1 uc002xps.1 uc002xpu.1 uc002xpv.1 uc002xpw.1 uc010zxd.1)
ENST00000478230 ENST00000372547(uc002xpy.1) ENST00000486336 ENST00000465997
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX21 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX21 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): SNX21 (NM_152897) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX21 |
Additional cDNA sequence: AF395845.1 AF523834.1 AK091359.1 AK095851.1 AK226120.1 AK293443.1 AK297622.1 AL591562.1 BC012904.1 BC019823.1 11 DOTS entries: DT.97852110 DT.97775420 DT.40213032 DT.100707832 DT.120817362 DT.439019 DT.100812146 DT.95336060 DT.100028476 DT.100812149 DT.95336063 24/121 AceView cDNA sequences (see all 121): AI376594 CK819910 CR601928 AA365778 AF395845 AI915413 BF061958 BM142124 NM_152897 AF523834 CD369894 AL591562 CR617424 BM677889 BQ771786 NM_033421 AI935964 Z39581 AW450013 AA365779 BU687546 AW173296 AK091359 BF570253
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SNX21 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|
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| SP1: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SNX21
|
Expression
for SNX21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCGGCTCTC
About this image
See SNX21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX21
SOURCE GeneReport for Unigene cluster: Hs.472854
UniProtKB/Swiss-Prot: SNX21_HUMAN, Q969T3Tissue specificity: Highly expressed in fetus liver, but only weakly expressed in brain, skeleton muscle, smoothmuscle, and cardiac muscle, kidney, and adrenal gland
SABiosciences Custom PCR Arrays for SNX21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX21
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX21 |
Orthologs
for SNX21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNX21 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for SNX21 (if available)
TreeFam Gene Tree for SNX21 (if available) |
Paralogs
for SNX21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNX21 gene
- SNX202
2 SIMAP similar genes for SNX21 using alignment to 5 protein entries: SNX21_HUMAN (see all proteins):C20orf161 SNX20
SNX21 for paralogs About GeneDecksing
|
Genomic Variants
for SNX21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX21 (44462449 - 44471914 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNX21: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX21 |
|
Disorders
/ Diseases
for SNX21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SNX21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX21 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SNX21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development. (PubMed id 12459172)1, 2, 3, 9 Zeng W.... Liu M. (2002)
- Sorting out the cellular functions of sorting nexins. (PubMed id 12461558)1, 3 Worby C.A. and Dixon J.E. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)1 Teasdale R.D.... Gleeson P.A. (2001)
- The Phox homology (PX) domain, a new player in phosph oinositide signalling. (PubMed id 11736640)1 Xu Y....Hong W. (2001)
|
External Searches for SNX21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNX21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNX21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNX21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX21 gene:
Search GeneIP for patents involving SNX21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNX21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX21 |
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| |  |  |  |  | | | | |
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 | | | SNX21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX21 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX21 |
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