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Aliases for SNX21 Gene

Aliases for SNX21 Gene

  • Sorting Nexin Family Member 21 2 3
  • Sorting Nexin L 3 4
  • C20orf161 3 4
  • SNX-L 3 4
  • Chromosome 20 Open Reading Frame 161 2
  • Sorting Nexin 21 3
  • Sorting Nexin-21 3
  • DJ337O18.4 3
  • PP3993 3
  • SNXL 4

External Ids for SNX21 Gene

Previous HGNC Symbols for SNX21 Gene

  • C20orf161

Previous GeneCards Identifiers for SNX21 Gene

  • GC20P043896
  • GC20P044462
  • GC20P041204

Summaries for SNX21 Gene

Entrez Gene Summary for SNX21 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX21 Gene

SNX21 (Sorting Nexin Family Member 21) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX20.

UniProtKB/Swiss-Prot for SNX21 Gene

  • May be involved in several stages of intracellular trafficking.

Gene Wiki entry for SNX21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX21 Gene

Genomics for SNX21 Gene

Regulatory Elements for SNX21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNX21 Gene

Start:
45,827,854 bp from pter
End:
45,843,275 bp from pter
Size:
15,422 bases
Orientation:
Plus strand

Genomic View for SNX21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX21 Gene

Proteins for SNX21 Gene

  • Protein details for SNX21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969T3-SNX21_HUMAN
    Recommended name:
    Sorting nexin-21
    Protein Accession:
    Q969T3
    Secondary Accessions:
    • Q5JZH5
    • Q5JZH6
    • Q5JZH7
    • Q8WUR6
    • Q9BR16

    Protein attributes for SNX21 Gene

    Size:
    373 amino acids
    Molecular mass:
    41365 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SNX21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX21 Gene

Proteomics data for SNX21 Gene at MOPED

Post-translational modifications for SNX21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX21 Gene

Domains for SNX21 Gene

Gene Families for SNX21 Gene

HGNC:
  • SNX :Sorting nexins
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for SNX21 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q969T3

UniProtKB/Swiss-Prot:

SNX21_HUMAN :
  • Q969T3
Domain:
  • The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX21: view

Function for SNX21 Gene

Molecular function for SNX21 Gene

UniProtKB/Swiss-Prot Function: May be involved in several stages of intracellular trafficking.

Gene Ontology (GO) - Molecular Function for SNX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX21: view

Phenotypes for SNX21 Gene

GenomeRNAi human phenotypes for SNX21:
genes like me logo Genes that share phenotypes with SNX21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX21

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SNX21 Gene

Localization for SNX21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX21 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX21 Gene COMPARTMENTS Subcellular localization image for SNX21 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SNX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with SNX21: view

Pathways for SNX21 Gene

SuperPathways for SNX21 Gene

No Data Available

Interacting Proteins for SNX21 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000418593%0d%0a9606.ENSP00000287490%0d%0a
Selected Interacting proteins: ENSP00000418593 for SNX21 Gene via STRING

Symbol External ID(s) Details
COX6A2

Gene Ontology (GO) - Biological Process for SNX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SNX21: view

No data available for Pathways by source for SNX21 Gene

Transcripts for SNX21 Gene

Unigene Clusters for SNX21 Gene

Sorting nexin family member 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX21

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX21 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: -
SP4: - -
SP5:
SP6: -
SP7: - - - - -
SP8: -

Relevant External Links for SNX21 Gene

GeneLoc Exon Structure for
SNX21
ECgene alternative splicing isoforms for
SNX21

Expression for SNX21 Gene

mRNA expression in normal human tissues for SNX21 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX21 Gene

SOURCE GeneReport for Unigene cluster for SNX21 Gene Hs.472854

mRNA Expression by UniProt/SwissProt for SNX21 Gene

Q969T3-SNX21_HUMAN
Tissue specificity: Highly expressed in fetus liver, but only weakly expressed in brain, skeleton muscle, smooth muscle, and cardiac muscle, kidney, and adrenal gland.
genes like me logo Genes that share expressions with SNX21: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SNX21 Gene

Orthologs for SNX21 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX21 35
  • 99.28 (n)
  • 98.38 (a)
SNX21 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX21 35
  • 89.14 (n)
  • 93.58 (a)
dog
(Canis familiaris)
Mammalia SNX21 35
  • 90.75 (n)
  • 93.41 (a)
SNX21 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx21 35
  • 88.15 (n)
  • 93.94 (a)
Snx21 16
Snx21 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX21 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx21 35
  • 88.26 (n)
  • 95.45 (a)
chicken
(Gallus gallus)
Aves SNX21 35
  • 70.59 (n)
  • 62.65 (a)
SNX21 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx21 35
  • 54.94 (n)
  • 52.03 (a)
zebrafish
(Danio rerio)
Actinopterygii snx21 35
  • 52.45 (n)
  • 46.54 (a)
snx21 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009095 35
  • 43.29 (n)
  • 32.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3077 35
  • 44.93 (n)
  • 32.97 (a)
CG3077 36
  • 25 (a)
OneToMany
Species with no ortholog for SNX21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX21 Gene

ENSEMBL:
Gene Tree for SNX21 (if available)
TreeFam:
Gene Tree for SNX21 (if available)

Paralogs for SNX21 Gene

Paralogs for SNX21 Gene

Selected SIMAP similar genes for SNX21 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SNX21: view

Variants for SNX21 Gene

Sequence variations from dbSNP and Humsavar for SNX21 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs197669 -- 45,840,292(+) TTGGC(C/T)GGGGT intron-variant, utr-variant-5-prime
rs197670 -- 45,839,873(-) ggagt(A/G)cactg intron-variant, upstream-variant-2KB
rs386155 -- 45,830,544(+) gtctc(C/T)AGTAG intron-variant
rs420093 -- 45,835,320(+) GTGGG(A/G)ATTAA intron-variant
rs448986 -- 45,833,864(+) GCCGA(C/T)CTCCA utr-variant-5-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX21 Gene

Variant ID Type Subtype PubMed ID
nsv833990 CNV Loss 17160897
nsv458993 CNV Loss 19166990

Relevant External Links for SNX21 Gene

HapMap Linkage Disequilibrium report
SNX21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX21 Gene

Disorders for SNX21 Gene

No disorders were found for SNX21 Gene.

No data available for UniProtKB/Swiss-Prot for SNX21 Gene

Publications for SNX21 Gene

  1. Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development. (PMID: 12459172) Zeng W. … Liu M. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 23
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby C.A. … Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SNX21 Gene

Sources for SNX21 Gene

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