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Aliases for SNX21 Gene

Aliases for SNX21 Gene

  • Sorting Nexin Family Member 21 2 3 5
  • Sorting Nexin L 3 4
  • C20orf161 3 4
  • SNX-L 3 4
  • Chromosome 20 Open Reading Frame 161 2
  • Sorting Nexin-21 3
  • DJ337O18.4 3
  • PP3993 3
  • SNXL 4

External Ids for SNX21 Gene

Previous HGNC Symbols for SNX21 Gene

  • C20orf161

Previous GeneCards Identifiers for SNX21 Gene

  • GC20P043896
  • GC20P044462
  • GC20P041204

Summaries for SNX21 Gene

Entrez Gene Summary for SNX21 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX21 Gene

SNX21 (Sorting Nexin Family Member 21) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX20.

UniProtKB/Swiss-Prot for SNX21 Gene

  • Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking.

Gene Wiki entry for SNX21 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX21 Gene

Genomics for SNX21 Gene

Regulatory Elements for SNX21 Gene

Enhancers for SNX21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G045924 1.5 Ensembl ENCODE dbSUPER 11.2 +91.5 91514 2.2 FOXA2 PKNOX1 ZNF133 ARID4B FEZF1 TCF12 ZNF766 GATA2 FOS JUNB WFDC3 PLTP NEURL2 CTSA SPATA25 TNNC2 SNX21 ACOT8 ZSWIM3 UBE2C
GH20G045917 1.5 Ensembl ENCODE dbSUPER 11 +85.6 85606 4.0 FOXA2 ARNT ARID4B FEZF1 ZNF48 GATA2 FOS MIER2 KAT8 MIER3 WFDC3 CTSA NEURL2 SPATA25 PLTP ACOT8 ZSWIM3 SNX21 TNNC2 UBE2C
GH20G045933 1.4 ENCODE dbSUPER 11.3 +102.7 102708 6.3 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PLTP WFDC3 ACOT8 ZSWIM3 SPATA25 NEURL2 CTSA SNX21 TNNC2 UBE2C
GH20G045909 1.3 ENCODE dbSUPER 10.8 +77.3 77335 3.7 HDGF PKNOX1 MLX CREB3L1 ZFP64 SIN3A ARID4B DMAP1 YY1 ZNF766 PLTP SLC12A5-AS1 ACOT8 ZSWIM3 SNX21 TNNC2 UBE2C DNTTIP1 WFDC3 SLC12A5
GH20G045817 1.4 Ensembl ENCODE dbSUPER 9.2 -15.7 -15701 1.5 HDAC1 KLF17 ZBTB40 ZEB1 TCF12 ZNF121 GLIS2 ZNF366 SCRT2 RCOR1 WFDC3 PLTP NCOA5 ACOT8 ZSWIM3 DNTTIP1 ZSWIM1 CTSA SPATA25 NEURL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNX21 on UCSC Golden Path with GeneCards custom track

Promoters for SNX21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137702 478 1401 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 PAF1

Genomic Location for SNX21 Gene

Chromosome:
20
Start:
45,833,622 bp from pter
End:
45,843,275 bp from pter
Size:
9,654 bases
Orientation:
Plus strand

Genomic View for SNX21 Gene

Genes around SNX21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX21 Gene

Proteins for SNX21 Gene

  • Protein details for SNX21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969T3-SNX21_HUMAN
    Recommended name:
    Sorting nexin-21
    Protein Accession:
    Q969T3
    Secondary Accessions:
    • Q5JZH5
    • Q5JZH6
    • Q5JZH7
    • Q8WUR6
    • Q9BR16

    Protein attributes for SNX21 Gene

    Size:
    373 amino acids
    Molecular mass:
    41365 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for SNX21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX21 Gene

Post-translational modifications for SNX21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX21 Gene

Domains & Families for SNX21 Gene

Protein Domains for SNX21 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q969T3

UniProtKB/Swiss-Prot:

SNX21_HUMAN :
  • The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX21: view

Function for SNX21 Gene

Molecular function for SNX21 Gene

UniProtKB/Swiss-Prot Function:
Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking.

Gene Ontology (GO) - Molecular Function for SNX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS --
GO:0008289 lipid binding IEA --
GO:0032266 phosphatidylinositol-3-phosphate binding ISS --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX21: view
genes like me logo Genes that share phenotypes with SNX21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNX21 Gene

Localization for SNX21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX21 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX21 gene
Compartment Confidence
endosome 5
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SNX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0016020 membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0031901 early endosome membrane ISS --
genes like me logo Genes that share ontologies with SNX21: view

Pathways & Interactions for SNX21 Gene

SuperPathways for SNX21 Gene

No Data Available

Interacting Proteins for SNX21 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000418593%0d%0a9606.ENSP00000373600%0d%0a
Selected Interacting proteins: Q969T3-SNX21_HUMAN ENSP00000418593 for SNX21 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SNX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SNX21: view

No data available for Pathways by source and SIGNOR curated interactions for SNX21 Gene

Drugs & Compounds for SNX21 Gene

No Compound Related Data Available

Transcripts for SNX21 Gene

Unigene Clusters for SNX21 Gene

Sorting nexin family member 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX21 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: -
SP4: - -
SP5:
SP6: -
SP7: - - - - -
SP8: -

Relevant External Links for SNX21 Gene

GeneLoc Exon Structure for
SNX21
ECgene alternative splicing isoforms for
SNX21

Expression for SNX21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX21 Gene

Protein differential expression in normal tissues from HIPED for SNX21 Gene

This gene is overexpressed in Pancreatic juice (35.5), Fetal heart (10.9), and Fetal testis (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX21 Gene



Protein tissue co-expression partners for SNX21 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNX21 Gene:

SNX21

SOURCE GeneReport for Unigene cluster for SNX21 Gene:

Hs.472854

mRNA Expression by UniProt/SwissProt for SNX21 Gene:

Q969T3-SNX21_HUMAN
Tissue specificity: Highly expressed in fetus liver, but only weakly expressed in brain, skeleton muscle, smooth muscle, and cardiac muscle, kidney, and adrenal gland.

Evidence on tissue expression from TISSUES for SNX21 Gene

  • Kidney(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with SNX21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX21 Gene

Orthologs for SNX21 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX21 34 35
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia SNX21 34 35
  • 90.75 (n)
cow
(Bos Taurus)
Mammalia SNX21 34
  • 89.14 (n)
rat
(Rattus norvegicus)
Mammalia Snx21 34
  • 88.26 (n)
mouse
(Mus musculus)
Mammalia Snx21 34 16 35
  • 88.15 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX21 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX21 34 35
  • 70.59 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx21 34
  • 54.94 (n)
zebrafish
(Danio rerio)
Actinopterygii snx21 34 35
  • 52.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3077 34 35
  • 44.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009095 34
  • 43.29 (n)
Species where no ortholog for SNX21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX21 Gene

ENSEMBL:
Gene Tree for SNX21 (if available)
TreeFam:
Gene Tree for SNX21 (if available)

Paralogs for SNX21 Gene

Paralogs for SNX21 Gene

(2) SIMAP similar genes for SNX21 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SNX21: view

Variants for SNX21 Gene

Sequence variations from dbSNP and Humsavar for SNX21 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000972499 -- 45,833,754(+) ATTCT(C/T)GGGCG upstream-variant-2KB, utr-variant-5-prime
rs1001109810 -- 45,833,347(+) AATCA(C/T)TATGT upstream-variant-2KB
rs1001281015 -- 45,839,560(+) AAAAC(A/C)AAACT intron-variant, upstream-variant-2KB
rs1001347726 -- 45,839,721(+) CCCCC(C/G/T)TCATC intron-variant, upstream-variant-2KB
rs1001693283 -- 45,832,189(+) CCTGT(A/G)GTCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNX21 Gene

Variant ID Type Subtype PubMed ID
nsv458993 CNV loss 19166990
nsv586132 CNV loss 21841781
nsv586133 CNV loss 21841781
nsv833990 CNV loss 17160897

Variation tolerance for SNX21 Gene

Residual Variation Intolerance Score: 84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.95; 91.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX21 Gene

Disorders for SNX21 Gene

Relevant External Links for SNX21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX21

No disorders were found for SNX21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX21 Gene

Publications for SNX21 Gene

  1. Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development. (PMID: 12459172) Zeng W. … Liu M. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 22 64
  2. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby C.A. … Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002) 2 3 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3 64
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64

Products for SNX21 Gene

Sources for SNX21 Gene

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