SNX20 Gene
protein-coding GIFtS: 47
GCID: GC16M050700
|
|
sorting nexin 20
| |
Aliases
for SNX20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sorting Nexin 201 2 | | Selectin Ligand Interactor Cytoplasmic 12 | | SLIC11 2 3 5 | | Selectin Ligand Interactor Cytoplasmic-12 | | Selectin Ligand-Interactor Cytoplasmic 12 3 | | Sorting Nexin-202 | | SLIC-11 | | |
Export aliases for SNX20 gene to outside databasesPrevious GC identifers: GC16M049258 GC16M036588 |
Summaries
for SNX20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNX20:
SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.(supplied byOMIM, Feb 2010)
UniProtKB/Swiss-Prot: SNX20_HUMAN, Q7Z614Function: Serves as a sorting protein that cycles P-selectin glycoprotein ligand 1 (PSLG1) into endosomes with noimpact on leukocytes recruitment
|
Genomic Views
for SNX20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNX20 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q12.1 Ensembl cytogenetic band: 16q12.1 HGNC cytogenetic band: 16q12.1SNX20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M050700: view genomic region
(about GC identifiers)
Start:
|
50,700,211 bp from pter |
End:
|
50,715,264 bp from pter |
Size:
|
15,054 bases |
Orientation:
|
minus strand |
|
Proteins
for SNX20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNX20_HUMAN, Q7Z614 (See
protein sequence)Recommended Name: Sorting nexin-20 Size: 316 amino acids; 36178 Da
Subunit: Interacts with SELPLG
Subcellular location: Cell membrane. Cytoplasm. Nucleus. Endosome. Endosome membrane; Peripheral membrane protein;Cytoplasmic side
Secondary accessions: A8K9D5 Q08E98 Q6P4H2 Q8IV59Alternative splicing: 4 isoforms: Q7Z614-1 Q7Z614-2 Q7Z614-3 Q7Z614-4 Explore the universe of human proteins at neXtProt for SNX20: NX_Q7Z614
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z614
SNX20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001138444.1 NP_699168.1 NP_878274.1
ENSEMBL proteins: ENSP00000388875 ENSP00000300590 ENSP00000454863 ENSP00000332062
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SNX20 for ontologies About GeneDecksing
SNX20 Antibody Products:
Assay Products for SNX20: |
Protein
Domains /
Families
for SNX20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX20 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7Z614ProtoNet protein and cluster: Q7Z614 1 Blocks protein family: IPB001683 Phox-like
UniProtKB/Swiss-Prot: SNX20_HUMAN, Q7Z614Domain: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomesSimilarity: Belongs to the sorting nexin familySimilarity: Contains 1 PX (phox homology) domain |
Function
for SNX20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNX20_HUMAN, Q7Z614Function: Serves as a sorting protein that cycles P-selectin glycoprotein ligand 1 (PSLG1) into endosomes with noimpact on leukocytes recruitment
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX20 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX20 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): SNX20 (NM_182854) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX20 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX20 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SNX20 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SNX20:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Snx20):
SNX20 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SNX20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX20
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for SNX20 (Q7Z6141, 2, 3 ENSP000003320624) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007154 | cell communication |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- |
SNX20 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNX20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNX20
Search CenterWatch for drugs/clinical trials and news about SNX20
|
Transcripts
for SNX20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNX20 gene (3 alternative transcripts): NM_001144972.1 NM_153337.2 NM_182854.2 Unigene Cluster for SNX20: Sorting nexin 20 Hs.715778 [show with all ESTs]Unigene Representative Sequence: NM_1533374 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000423026 ENST00000300590(uc010vgp.1 uc002egi.3 uc021thz.1)
ENST00000568993 ENST00000330943(uc002egk.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX20 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX20 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SNX20 (NM_182854) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX20 |
Additional cDNA sequence: AK055837.1 AK292650.1 AK292705.1 AY302441.1 BC027944.1 BC063423.1 BC119626.1 4 DOTS entries: DT.101978447 DT.95372786 DT.95372785 DT.40108659 24/99 AceView cDNA sequences (see all 99): AI131560 NM_153337 AI218443 AI383802 AI480235 BC027944 AY302441 AW592491 AI017999 AI243205 AI290165 AI989740 AI762326 AI089374 NM_182854 CB265766 AA938258 CN480372 BF446287 AA489631 AW082334 AW469821 AW467091 BQ230734
GeneLoc Exon Structure
|
Expression
for SNX20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTGGCATA
About this image
See SNX20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX20
SOURCE GeneReport for Unigene cluster: Hs.715778
SABiosciences Custom PCR Arrays for SNX20
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX20 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX20 |
Orthologs
for SNX20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNX20 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for SNX20 (if available)
TreeFam Gene Tree for SNX20 (if available) |
Paralogs
for SNX20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNX20 gene
- SNX212
1 SIMAP similar gene for SNX20 using alignment to 1 protein entry: SNX20_HUMAN:SNX21
SNX20 for paralogs About GeneDecksing
|
Genomic Variants
for SNX20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX20 (50700211 - 50715264 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNX20: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX20 |
|
Disorders
/ Diseases
for SNX20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNX20 for disorders About GeneDecksing
OMIM gene information: 613281
OMIM disorders: --
1  disease for SNX20: About MalaCardsleprosy
Human Genome Epidemiology (HuGE) Navigator: SNX20 (1 document)
Export disorders for SNX20 gene to outside databases
|
Publications
for SNX20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX20 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SNX20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. (PubMed id 18196517)1, 2, 3 Schaff U.Y.... Simon S.I. (2008)
- The Phox (PX) domain proteins and membrane traffic. (PubMed id 16782399)1, 3 Seet L.F. and Hong W. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genomewide association study of leprosy. (PubMed id 20018961)1 Zhang F.R....Liu J.J. (2009)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles. (PubMed id 8586417)1 Okubo K....Matsubara K. (1995)
|
External Searches for SNX20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNX20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNX20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNX20 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX20 gene:
Search GeneIP for patents involving SNX20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNX20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SNX20 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX20 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX20 | | | OriGene Protein Over-expression Lysate for SNX20 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SNX20 | | OriGene 3'-UTR Clone for SNX20 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX20 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX20 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SNX20 | | OriGene Custom Protein Services for SNX20 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX20 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX20 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX20 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX20 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SNX20 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SNX20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX20 |
|  |  |  | | | | Search ThermoFisher Antibodies for SNX20 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX20 |
|
|
|
|
