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Aliases for SNX20 Gene

Aliases for SNX20 Gene

  • Sorting Nexin 20 2 3 5
  • Selectin Ligand-Interactor Cytoplasmic 1 3 4
  • SLIC1 3 4
  • Selectin Ligand Interactor Cytoplasmic 1 2
  • Sorting Nexin-20 3
  • SLIC-1 4

External Ids for SNX20 Gene

Previous GeneCards Identifiers for SNX20 Gene

  • GC16M049258
  • GC16M036588

Summaries for SNX20 Gene

Entrez Gene Summary for SNX20 Gene

  • SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.[supplied by OMIM, Feb 2010]

GeneCards Summary for SNX20 Gene

SNX20 (Sorting Nexin 20) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX21.

UniProtKB/Swiss-Prot for SNX20 Gene

  • May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX20 Gene

Genomics for SNX20 Gene

Regulatory Elements for SNX20 Gene

Enhancers for SNX20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G050678 1.9 FANTOM5 Ensembl ENCODE dbSUPER 31.4 -1.3 -1251 8.8 HDGF PKNOX1 FOXA2 WRNIP1 ZFP64 SIN3A ZNF48 GATA2 ELK1 ZNF143 NOD2 SNX20 CYLD BRD7 ADCY7
GH16G050740 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.9 -63.1 -63132 7.7 HDGF PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 NOD2 SNX20 CYLD LOC102724907 BRD7 PAPD5 ADCY7 LOC105371251
GH16G050695 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -16.6 -16594 5.4 HDGF PKNOX1 ATF1 DMAP1 ZNF766 ZNF207 REST MIER2 PPARG TBX21 NOD2 SNX20 CYLD ADCY7 GC16P050707 PIR45400
GH16G050718 1 ENCODE dbSUPER 13.2 -38.2 -38242 1.4 ELF3 CTCF FOXA2 SAP130 MLX MAX CEBPG RAD21 THRB ZNF48 NOD2 SNX20 ENSG00000270120 CYLD
GH16G050721 0.9 ENCODE dbSUPER 12.5 -40.9 -40932 1.6 FOXA2 NFIA ETV1 HLF ZMYM3 TBX21 FOXA1 NFIC ZGPAT PBX2 NOD2 SNX20 CYLD ENSG00000270120
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNX20 on UCSC Golden Path with GeneCards custom track

Promoters for SNX20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085819 253 601 CTCF TBL1XR1 MAX EBF1 RARA POLR2A MIXL1 MTA2 NR2F1 DPF2

Transcription factor binding sites by QIAGEN in the SNX20 gene promoter:

Genomic Location for SNX20 Gene

Chromosome:
16
Start:
50,666,300 bp from pter
End:
50,681,353 bp from pter
Size:
15,054 bases
Orientation:
Minus strand

Genomic View for SNX20 Gene

Genes around SNX20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX20 Gene

Proteins for SNX20 Gene

  • Protein details for SNX20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z614-SNX20_HUMAN
    Recommended name:
    Sorting nexin-20
    Protein Accession:
    Q7Z614
    Secondary Accessions:
    • A8K9D5
    • Q08E98
    • Q6P4H2
    • Q8IV59

    Protein attributes for SNX20 Gene

    Size:
    316 amino acids
    Molecular mass:
    36178 Da
    Quaternary structure:
    • Interacts with SELPLG (PubMed:18196517). Interaction with SELPLG is controversial.

    Alternative splice isoforms for SNX20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX20 Gene

Post-translational modifications for SNX20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX20 Gene

No data available for DME Specific Peptides for SNX20 Gene

Domains & Families for SNX20 Gene

Gene Families for SNX20 Gene

Protein Domains for SNX20 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z614

UniProtKB/Swiss-Prot:

SNX20_HUMAN :
  • The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX20: view

Function for SNX20 Gene

Molecular function for SNX20 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.

Gene Ontology (GO) - Molecular Function for SNX20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS --
GO:0008289 lipid binding IEA --
GO:0032266 phosphatidylinositol-3-phosphate binding ISS --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX20: view
genes like me logo Genes that share phenotypes with SNX20: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SNX20

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX20 Gene

Localization for SNX20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX20 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX20 gene
Compartment Confidence
nucleus 5
endosome 5
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SNX20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with SNX20: view

Pathways & Interactions for SNX20 Gene

SuperPathways for SNX20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SNX20: view

No data available for Pathways by source and SIGNOR curated interactions for SNX20 Gene

Drugs & Compounds for SNX20 Gene

No Compound Related Data Available

Transcripts for SNX20 Gene

Unigene Clusters for SNX20 Gene

Sorting nexin 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX20 Gene

No ASD Table

Relevant External Links for SNX20 Gene

GeneLoc Exon Structure for
SNX20
ECgene alternative splicing isoforms for
SNX20

Expression for SNX20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX20 Gene

mRNA differential expression in normal tissues according to GTEx for SNX20 Gene

This gene is overexpressed in Whole Blood (x24.1) and Spleen (x4.9).

Protein differential expression in normal tissues from HIPED for SNX20 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.0) and CD4 Tcells (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNX20 Gene



Protein tissue co-expression partners for SNX20 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNX20 Gene:

SNX20

SOURCE GeneReport for Unigene cluster for SNX20 Gene:

Hs.715778

Evidence on tissue expression from TISSUES for SNX20 Gene

  • Blood(4.1)
  • Lung(3.5)
genes like me logo Genes that share expression patterns with SNX20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX20 Gene

Orthologs for SNX20 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX20 34 35
  • 98.73 (n)
dog
(Canis familiaris)
Mammalia SNX20 34 35
  • 82.59 (n)
cow
(Bos Taurus)
Mammalia SNX20 34 35
  • 82.43 (n)
mouse
(Mus musculus)
Mammalia Snx20 34 16 35
  • 80.13 (n)
rat
(Rattus norvegicus)
Mammalia Snx20 34
  • 78.85 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX20 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX20 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857504 34
  • 60.61 (n)
SNX20 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX20 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495982 34
  • 55.22 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC794759 34
  • 56.07 (n)
snx20 35
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3077 35
  • 23 (a)
OneToMany
Species where no ortholog for SNX20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX20 Gene

ENSEMBL:
Gene Tree for SNX20 (if available)
TreeFam:
Gene Tree for SNX20 (if available)

Paralogs for SNX20 Gene

Paralogs for SNX20 Gene

(1) SIMAP similar genes for SNX20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SNX20: view

Variants for SNX20 Gene

Sequence variations from dbSNP and Humsavar for SNX20 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000381424 -- 50,676,712(+) TCTCG(G/T)GGCAC intron-variant
rs1000632392 -- 50,677,807(+) AGAGT(A/T)TTAAA intron-variant
rs1000646066 -- 50,682,678(+) GATTA(C/T)GCCAA upstream-variant-2KB
rs1000656894 -- 50,678,060(+) AAAAA(-/T)TATCC intron-variant
rs1000686688 -- 50,682,522(+) TTTTT(C/G)TTTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNX20 Gene

Variant ID Type Subtype PubMed ID
esv3638608 CNV gain 21293372

Variation tolerance for SNX20 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX20 Gene

Disorders for SNX20 Gene

Relevant External Links for SNX20

Genetic Association Database (GAD)
SNX20
Human Genome Epidemiology (HuGE) Navigator
SNX20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX20

No disorders were found for SNX20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX20 Gene

Publications for SNX20 Gene

  1. SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. (PMID: 18196517) Schaff U.Y. … Simon S.I. (Eur. J. Immunol. 2008) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genomewide association study of leprosy. (PMID: 20018961) Zhang F.R. … Liu J.J. (N. Engl. J. Med. 2009) 3 46 64
  4. The Phox (PX) domain proteins and membrane traffic. (PMID: 16782399) Seet L.F. … Hong W. (Biochim. Biophys. Acta 2006) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SNX20 Gene

Sources for SNX20 Gene

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