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Aliases for SNX20 Gene

Aliases for SNX20 Gene

  • Sorting Nexin 20 2 3 5
  • Selectin Ligand Interactor Cytoplasmic 1 2 3
  • Selectin Ligand-Interactor Cytoplasmic 1 3 4
  • SLIC1 3 4
  • Selectin Ligand Interactor Cytoplasmic-1 3
  • SLIC-1 4

External Ids for SNX20 Gene

Previous GeneCards Identifiers for SNX20 Gene

  • GC16M049258
  • GC16M036588

Summaries for SNX20 Gene

Entrez Gene Summary for SNX20 Gene

  • SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.[supplied by OMIM, Feb 2010]

GeneCards Summary for SNX20 Gene

SNX20 (Sorting Nexin 20) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX21.

UniProtKB/Swiss-Prot for SNX20 Gene

  • May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX20 Gene

Genomics for SNX20 Gene

Regulatory Elements for SNX20 Gene

Enhancers for SNX20 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNX20 on UCSC Golden Path with GeneCards custom track

Promoters for SNX20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNX20 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SNX20 gene promoter:

Genomic Location for SNX20 Gene

Chromosome:
16
Start:
50,666,300 bp from pter
End:
50,681,353 bp from pter
Size:
15,054 bases
Orientation:
Minus strand

Genomic View for SNX20 Gene

Genes around SNX20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX20 Gene

Proteins for SNX20 Gene

  • Protein details for SNX20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z614-SNX20_HUMAN
    Recommended name:
    Sorting nexin-20
    Protein Accession:
    Q7Z614
    Secondary Accessions:
    • A8K9D5
    • Q08E98
    • Q6P4H2
    • Q8IV59

    Protein attributes for SNX20 Gene

    Size:
    316 amino acids
    Molecular mass:
    36178 Da
    Quaternary structure:
    • Interacts with SELPLG (PubMed:18196517). Interaction with SELPLG is controversial.

    Alternative splice isoforms for SNX20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX20 Gene

Proteomics data for SNX20 Gene at MOPED

Post-translational modifications for SNX20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX20 Gene

No data available for DME Specific Peptides for SNX20 Gene

Domains & Families for SNX20 Gene

Gene Families for SNX20 Gene

Protein Domains for SNX20 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z614

UniProtKB/Swiss-Prot:

SNX20_HUMAN :
  • The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX20: view

Function for SNX20 Gene

Molecular function for SNX20 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.

Gene Ontology (GO) - Molecular Function for SNX20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0032266 phosphatidylinositol-3-phosphate binding ISS --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX20: view
genes like me logo Genes that share phenotypes with SNX20: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SNX20

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX20 Gene

Localization for SNX20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX20 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX20 Gene COMPARTMENTS Subcellular localization image for SNX20 gene
Compartment Confidence
endosome 5
nucleus 4
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SNX20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with SNX20: view

Pathways & Interactions for SNX20 Gene

SuperPathways for SNX20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX20 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNX20 Gene

Drugs & Compounds for SNX20 Gene

No Compound Related Data Available

Transcripts for SNX20 Gene

Unigene Clusters for SNX20 Gene

Sorting nexin 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX20 Gene

No ASD Table

Relevant External Links for SNX20 Gene

GeneLoc Exon Structure for
SNX20
ECgene alternative splicing isoforms for
SNX20

Expression for SNX20 Gene

mRNA expression in normal human tissues for SNX20 Gene

mRNA differential expression in normal tissues according to GTEx for SNX20 Gene

This gene is overexpressed in Whole Blood (x24.1) and Spleen (x4.9).

Protein differential expression in normal tissues from HIPED for SNX20 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.0) and CD4 Tcells (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNX20 Gene



SOURCE GeneReport for Unigene cluster for SNX20 Gene Hs.715778

genes like me logo Genes that share expression patterns with SNX20: view

Protein tissue co-expression partners for SNX20 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SNX20 Gene

Orthologs for SNX20 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNX20 35
  • 82.43 (n)
  • 78.73 (a)
SNX20 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX20 35
  • 82.59 (n)
  • 76.58 (a)
SNX20 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx20 35
  • 80.13 (n)
  • 78.21 (a)
Snx20 16
Snx20 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNX20 35
  • 98.73 (n)
  • 97.47 (a)
SNX20 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx20 35
  • 78.85 (n)
  • 75.64 (a)
oppossum
(Monodelphis domestica)
Mammalia SNX20 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX20 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857504 35
  • 60.61 (n)
  • 58.18 (a)
SNX20 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX20 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495982 35
  • 55.22 (n)
  • 51.53 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC794759 35
  • 56.07 (n)
  • 47.13 (a)
snx20 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3077 36
  • 23 (a)
OneToMany
Species with no ortholog for SNX20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX20 Gene

ENSEMBL:
Gene Tree for SNX20 (if available)
TreeFam:
Gene Tree for SNX20 (if available)

Paralogs for SNX20 Gene

Paralogs for SNX20 Gene

(1) SIMAP similar genes for SNX20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SNX20: view

Variants for SNX20 Gene

Sequence variations from dbSNP and Humsavar for SNX20 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1131716 - 50,677,423(-) CCTCC(C/T)GCACC reference, missense
rs6596 -- 50,675,812(-) GAGAT(C/G/T)GCTTC reference, synonymous-codon
rs9888893 -- 50,678,236(+) GCAGG(C/T)AGATA intron-variant
rs13339019 -- 50,677,310(+) GCCTC(C/T)TGCTG intron-variant
rs9926569 -- 50,682,396(+) cccag(C/T)gtgtg upstream-variant-2KB

Variation tolerance for SNX20 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SNX20 Gene

Disorders for SNX20 Gene

Relevant External Links for SNX20

Genetic Association Database (GAD)
SNX20
Human Genome Epidemiology (HuGE) Navigator
SNX20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX20

No disorders were found for SNX20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX20 Gene

Publications for SNX20 Gene

  1. SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. (PMID: 18196517) Schaff U.Y. … Simon S.I. (Eur. J. Immunol. 2008) 2 3 4 67
  2. The Phox (PX) domain proteins and membrane traffic. (PMID: 16782399) Seet L.F. … Hong W. (Biochim. Biophys. Acta 2006) 2 3
  3. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. (PMID: 25642632) Liu H. … Zhang F. (Nat. Genet. 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3

Products for SNX20 Gene

Sources for SNX20 Gene

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