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Aliases for SNX2 Gene

Aliases for SNX2 Gene

  • Sorting Nexin 2 2 3
  • Transformation-Related Gene 9 Protein 3 4
  • TRG-9 3 4
  • Sorting Nexin-2 3
  • CTB-36H16.2 3

External Ids for SNX2 Gene

Previous GeneCards Identifiers for SNX2 Gene

  • GC05P121741
  • GC05P122437
  • GC05P122141
  • GC05P122186
  • GC05P122138
  • GC05P122110
  • GC05P117298

Summaries for SNX2 Gene

Entrez Gene Summary for SNX2 Gene

  • This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013]

GeneCards Summary for SNX2 Gene

SNX2 (Sorting Nexin 2) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include phosphatidylinositol binding and protein transporter activity. An important paralog of this gene is SNX4.

UniProtKB/Swiss-Prot for SNX2 Gene

  • Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901).

Gene Wiki entry for SNX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX2 Gene

Genomics for SNX2 Gene

Regulatory Elements for SNX2 Gene

Genomic Location for SNX2 Gene

Start:
122,774,996 bp from pter
End:
122,834,539 bp from pter
Size:
59,544 bases
Orientation:
Plus strand

Genomic View for SNX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX2 Gene

Proteins for SNX2 Gene

  • Protein details for SNX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60749-SNX2_HUMAN
    Recommended name:
    Sorting nexin-2
    Protein Accession:
    O60749
    Secondary Accessions:
    • B3KN44
    • B4DEK4
    • B7Z408
    • O43650
    • P82862
    • Q53XK8
    • Q597H6
    • Q9BTS8

    Protein attributes for SNX2 Gene

    Size:
    519 amino acids
    Molecular mass:
    58471 Da
    Quaternary structure:
    • Predominantly forms heterodimers with BAR domain-containing sorting nexins SNX5, SNX6 and SNX32; can self-associate to form homodimers (PubMed:23085988). The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also descibed as vacuolar protein sorting subcomplex (VPS), and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity (Probable). Interacts with SNX5, SNX6, SNX32, VPS26A, VPS29, VPS35, FNBP1, KALRN, RHOG (GDP-bound form) (PubMed:11438682, PubMed:14596906, PubMed:17101778, PubMed:19935774., PubMed:19619496, PubMed:20604901, PubMed:23085988).

    Alternative splice isoforms for SNX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX2 Gene

Proteomics data for SNX2 Gene at MOPED

Post-translational modifications for SNX2 Gene

  • Ubiquitination at Lys116 and Lys248
  • Modification sites at PhosphoSitePlus

Other Protein References for SNX2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SNX2 Gene

Domains for SNX2 Gene

Gene Families for SNX2 Gene

HGNC:
  • SNX :Sorting nexins

Protein Domains for SNX2 Gene

Suggested Antigen Peptide Sequences for SNX2 Gene

Graphical View of Domain Structure for InterPro Entry

O60749

UniProtKB/Swiss-Prot:

SNX2_HUMAN :
  • O60749
Domain:
  • The BAR domain is able to sense membrane curvature upon dimerization. Membrane remodeling seems to implicate insertion of a N-terminal amphipatric helix (AH) in the membrane (Probable).
  • Contains 1 BAR domain.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX2: view

Function for SNX2 Gene

Molecular function for SNX2 Gene

UniProtKB/Swiss-Prot Function: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901).

Gene Ontology (GO) - Molecular Function for SNX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IDA 9819414
GO:0005158 insulin receptor binding IDA 9819414
GO:0005515 protein binding IPI 11278302
GO:0035091 phosphatidylinositol binding IBA --
GO:1990459 transferrin receptor binding IDA 9819414
genes like me logo Genes that share ontologies with SNX2: view
genes like me logo Genes that share phenotypes with SNX2: view

Animal Models for SNX2 Gene

MGI Knock Outs for SNX2:

miRNA for SNX2 Gene

miRTarBase miRNAs that target SNX2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SNX2 Gene

Localization for SNX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX2 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269 PubMed:18088323, ECO:0000269 PubMed:20604901}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX2 Gene COMPARTMENTS Subcellular localization image for SNX2 gene
Compartment Confidence
endosome 5
cytosol 3
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SNX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11279102
GO:0010008 endosome membrane IDA 15673616
GO:0016020 membrane IDA 9819414
GO:0016023 cytoplasmic membrane-bounded vesicle --
GO:0019898 extrinsic component of membrane IBA --
genes like me logo Genes that share ontologies with SNX2: view

Pathways for SNX2 Gene

genes like me logo Genes that share pathways with SNX2: view

Pathways by source for SNX2 Gene

Gene Ontology (GO) - Biological Process for SNX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006897 endocytosis IEA --
GO:0016050 vesicle organization IBA --
GO:0034498 early endosome to Golgi transport IBA --
GO:0042147 retrograde transport, endosome to Golgi IMP 20138391
genes like me logo Genes that share ontologies with SNX2: view

Compounds for SNX2 Gene

(1) Novoseek inferred chemical compound relationships for SNX2 Gene

Compound -log(P) Hits PubMed IDs
mannose 6-phosphate 71.6 2
genes like me logo Genes that share compounds with SNX2: view

Transcripts for SNX2 Gene

Unigene Clusters for SNX2 Gene

Sorting nexin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX2 Gene

No ASD Table

Relevant External Links for SNX2 Gene

GeneLoc Exon Structure for
SNX2
ECgene alternative splicing isoforms for
SNX2

Expression for SNX2 Gene

mRNA expression in normal human tissues for SNX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX2 Gene

SOURCE GeneReport for Unigene cluster for SNX2 Gene Hs.713554

genes like me logo Genes that share expressions with SNX2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX2 Gene

Orthologs for SNX2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX2 35
  • 99.74 (n)
  • 99.42 (a)
SNX2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX2 35
  • 94.8 (n)
  • 97.3 (a)
SNX2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX2 35
  • 96.19 (n)
  • 99.25 (a)
SNX2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx2 35
  • 92.36 (n)
  • 98.07 (a)
Snx2 16
Snx2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX2 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx2 35
  • 92.94 (n)
  • 97.69 (a)
chicken
(Gallus gallus)
Aves SNX2 35
  • 85.71 (n)
  • 90.93 (a)
SNX2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX2 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia snx2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia snx2 35
  • 78.69 (n)
  • 87.52 (a)
Str.6438 35
zebrafish
(Danio rerio)
Actinopterygii snx2 35
  • 69.17 (n)
  • 76.83 (a)
SNX2 36
  • 68 (a)
OneToOne
wufj81a03 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009255 35
  • 55.81 (n)
  • 53.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta Snx1 35
  • 53.26 (n)
  • 53 (a)
Snx1 36
  • 48 (a)
OneToMany
CG2774 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea snx-1 35
  • 46.97 (n)
  • 37.86 (a)
snx-1 36
  • 36 (a)
OneToMany
C05D9.1 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX4 36
  • 18 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04137 35
  • 45.82 (n)
  • 37.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for SNX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX2 Gene

ENSEMBL:
Gene Tree for SNX2 (if available)
TreeFam:
Gene Tree for SNX2 (if available)

Paralogs for SNX2 Gene

Paralogs for SNX2 Gene

Selected SIMAP similar genes for SNX2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SNX2 Gene

genes like me logo Genes that share paralogs with SNX2: view

Variants for SNX2 Gene

Sequence variations from dbSNP and Humsavar for SNX2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs13662 -- 122,829,622(+) CATTC(C/T)TACCT reference, synonymous-codon
rs720952 -- 122,834,498(-) CATGT(A/C)TAAAT utr-variant-3-prime
rs720953 -- 122,834,269(-) TGTGC(A/C)TTAAA utr-variant-3-prime
rs725638 -- 122,827,706(+) TCTTA(C/T)TTTAA intron-variant
rs725639 -- 122,827,889(+) CATCA(A/G)AAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX2 Gene

Variant ID Type Subtype PubMed ID
nsv830471 CNV Gain 17160897

Relevant External Links for SNX2 Gene

HapMap Linkage Disequilibrium report
SNX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX2 Gene

Disorders for SNX2 Gene

No disorders were found for SNX2 Gene.

No data available for UniProtKB/Swiss-Prot for SNX2 Gene

Publications for SNX2 Gene

  1. Identification of a family of sorting nexin molecules and characterization of their association with receptors. (PMID: 9819414) Haft C.R. … Taylor S.I. (Mol. Cell. Biol. 1998) 2 3 4 23
  2. The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. (PMID: 11438682) Fuchs U. … Borkhardt A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  3. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. (PMID: 17101778) Rojas R. … Bonifacino J.S. (Mol. Cell. Biol. 2007) 3 4 23
  4. Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin. (PMID: 20138391) Lieu Z.Z. … Gleeson P.A. (Eur. J. Cell Biol. 2010) 3 4 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SNX2 Gene

Sources for SNX2 Gene

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