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SNX2 Gene

protein-coding   GIFtS: 54
GCID: GC05P122110

Sorting Nexin 2

  Search for SNX2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sorting Nexin 21 2
Transformation-Related Gene 9 Protein2 3
TRG-92 3
CTB-36H16.22
Sorting Nexin-22

External Ids:    HGNC: 111731   Entrez Gene: 66432   Ensembl: ENSG000002053027   OMIM: 6059295   UniProtKB: O607493   

Export aliases for SNX2 gene to outside databases

Previous GC identifers: GC05P121741 GC05P122437 GC05P122141 GC05P122186 GC05P122138 GC05P117298


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNX2 Gene:
This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain.
The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic
pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in
multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and
7. (provided by RefSeq, May 2013)

GeneCards Summary for SNX2 Gene:
SNX2 (sorting nexin 2) is a protein-coding gene. GO annotations related to this gene include protein transporter activity and phosphatidylinositol binding. An important paralog of this gene is SNX30.

UniProtKB/Swiss-Prot: SNX2_HUMAN, O60749
Function: May be involved in several stages of intracellular trafficking. Component of the retromer complex, a
complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi
network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or
phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)

Gene Wiki entry for SNX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SNX2 gene promoter:
         p53   AML1a   NF-kappaB   GATA-1   Meis-1b   AREB6   N-Myc   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNX2 promoter sequence
   Search Chromatin IP Primers for SNX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23   Ensembl cytogenetic band:  5q23.2   HGNC cytogenetic band: 5q23.2

SNX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P122110:  view genomic region     (about GC identifiers)

Start:
122,110,691 bp from pter      End:
122,165,803 bp from pter
Size:
55,113 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SNX2_HUMAN, O60749 (See protein sequence)
Recommended Name: Sorting nexin-2  
Size: 519 amino acids; 58471 Da
Subunit: Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2.
Interacts with FNBP1. Interacts with SNX6
Secondary accessions: B3KN44 O43650 P82862 Q53XK8 Q597H6 Q9BTS8

Explore the universe of human proteins at neXtProt for SNX2: NX_O60749

Explore proteomics data for SNX2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys116, Lys248
  • Modification sites at PhosphoSitePlus

  • See SNX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265128.1  NP_003091.2  

    ENSEMBL proteins: 
     ENSP00000368831   ENSP00000422560   ENSP00000422413   ENSP00000421663  
    Reactome Protein details: O60749

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SNX: Sorting nexins

    4 InterPro protein domains:
     IPR005329 Sorting_nexin_N
     IPR015404 Vps5_C
     IPR028653 SNX2
     IPR001683 Phox

    Graphical View of Domain Structure for InterPro Entry O60749

    ProtoNet protein and cluster: O60749

    2 Blocks protein domains:
    IPB001683 Phox-like
    IPB005329 Sorting nexin


    UniProtKB/Swiss-Prot: SNX2_HUMAN, O60749
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain


    Find genes that share domains with SNX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNX2_HUMAN, O60749
    Function: May be involved in several stages of intracellular trafficking. Component of the retromer complex, a
    complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi
    network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or
    phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11278302
    GO:0008565protein transporter activity ----
    GO:0035091phosphatidylinositol binding IBA--
         
    Find genes that share ontologies with SNX2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SNX2:
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Snx2):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  mortality/aging 
     nervous system  normal 

    Find genes that share phenotypes with SNX2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Snx2tm1Mag for SNX2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNX2
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    miRNA
    Products:
        
    miRTarBase miRNAs that target SNX2:
    hsa-let-7a-5p (MIRT052540), hsa-mir-30c-5p (MIRT047884), hsa-mir-26b-5p (MIRT029279)

    Block miRNA regulation of human, mouse, rat SNX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX2 (see all 27):
    hsa-miR-124* hsa-miR-4291 hsa-miR-140-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-410 hsa-miR-641 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSNX2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNX2
    Predesigned siRNA for gene silencing in human, mouse, rat SNX2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for SNX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNX2 (NM_003100)
    Sino Biological Human cDNA Clone for SNX2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SNX2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNX2_HUMAN, O60749: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11279102
    GO:0010008endosome membrane IDA15673616
    GO:0016023cytoplasmic membrane-bounded vesicle IBA--
    GO:0030904retromer complex IEA--
    GO:0031901early endosome membrane IEA--

    Find genes that share ontologies with SNX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNX2 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32
    2TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway


    Find genes that share SuperPaths with SNX2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNX2
        TGF-beta Receptor Signaling Pathway


    1 Reactome Pathway for SNX2
        Golgi Associated Vesicle Biogenesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNX2
    Interactions:

        GeneGlobe Interaction Network for SNX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNX2 (O607491, 2, 3 ENSP000003688314) via UniProtKB, MINT, STRING, and/or I2D (see all 644)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNBP1Q96RU31, 2, 3, ENSP000004136254EBI-1046690,EBI-1111248 MINT-7026677 MINT-7027275 I2D: score=6 STRING: ENSP00000413625
    WDFY2Q96P533, ENSP000002981254I2D: score=6 STRING: ENSP00000298125
    DERL1Q9BUN83, ENSP000002595124I2D: score=5 STRING: ENSP00000259512
    ACVR1BP368963, ENSP000002579634I2D: score=3 STRING: ENSP00000257963
    SNX1Q135963, ENSP000003696384I2D: score=3 STRING: ENSP00000369638
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IBA--
    GO:0006897endocytosis IEA--
    GO:0007154cell communication ----

    Find genes that share ontologies with SNX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNX2

    1 Novoseek inferred chemical compound relationship for SNX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 71.6 2 17101778 (2)



    Find genes that share compounds with SNX2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNX2 gene (2 alternative transcripts): 
    NM_001278199.1  NM_003100.3  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379516(uc003kte.3) ENST00000512394 ENST00000506874 ENST00000505934
    ENST00000505854 ENST00000514949(uc011cwn.2) ENST00000510372 ENST00000511365
    ENST00000509281 ENST00000506847 ENST00000514030 ENST00000507321 ENST00000507852

    miRNA
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    Block miRNA regulation of human, mouse, rat SNX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX2 (see all 27):
    hsa-miR-124* hsa-miR-4291 hsa-miR-140-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-410 hsa-miR-641 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSNX2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SNX2
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    Primer
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    OriGene qPCR primer pairs and template standards for SNX2
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      QuantiTect SYBR Green Assays in human, mouse, rat SNX2
      QuantiFast Probe-based Assays in human, mouse, rat SNX2

    Selected AceView cDNA sequences (see all 331):

    AA992761 NM_003100 CA777232 AL708726 BQ225976 BG818770 BU160692 BM449745 
    BM802771 BE018316 BU623995 BQ574392 AW235914 CA309632 BM454596 AW150876 
    BM930213 AI968529 BT009841 AA745878 BQ220652 H96795 CD106682 BC003382 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATTCTGCA
    SNX2 Expression
    About this image


    SNX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    SNX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNX2 Protein Expression
        Custom PCR Arrays for SNX2
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    QuantiFast Probe-based Assays in human, mouse, rat SNX2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SNX2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snx21 , 5 sorting nexin 21, 5 92.36(n)1
    98.07(a)1
      18 (28.99 cM)5
    678041  NM_026386.11  NP_080662.11 
     531763655 
    chicken
    (Gallus gallus)
    Aves SNX21 sorting nexin 2 85.71(n)
    90.93(a)
      426797  NM_001012607.2  NP_001012625.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNX26
    sorting nexin 2
    92(a)
    1 ↔ 1
    GL343193.1(12173354-12204015)
    African clawed frog
    (Xenopus laevis)
    Amphibia snx2-prov2 sorting nexin 2 79.17(n)    BC054996.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj81a032 Transcribed sequence with moderate similarity to protein more 76.56(n)    CD594000.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG27743
    Snx11
    intracellular protein transport3
    Sorting nexin 11
    52(a)3
    53.26(n)1
    53(a)1
      23F33
    335601  NM_134933.11  NP_608777.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C05D9.13
    snx-11
    snx-11 35(a)3
    46.97(n)1
    37.86(a)1
      X(1164317-1167717)3
    1804681  NM_075815.41  NP_508216.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNX46
    Sorting nexin, involved in retrieval of late-Golgi...
    18(a)
    1 → many
    X(378825-380096) YJL036W


    ENSEMBL Gene Tree for SNX2 (if available)
    TreeFam Gene Tree for SNX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNX2 gene
    SNX302  SNX72  SNX12  SNX42  
    3 SIMAP similar genes for SNX2 using alignment to 4 protein entries:     SNX2_HUMAN (see all proteins):
    SNX1    SNX7    SNX3

    Find genes that share paralogs with SNX2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SNX2
    PGOHUM00000245208 PGOHUM00000250928


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNX2 (see all 1212)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1119955911,2
    C--117353271(+) TATATACACACACA
    CACACAC
    /-
    ACACA
    1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1831503361,2
    --122108818(+) TTTTTA/GGCACC 1 -- us2k10--------
    rs1878221791,2
    --122108857(+) GGAAAC/TGAAAC 1 -- us2k10--------
    rs1416879471,2
    C--122108870(+) CTAATA/GATATT 1 -- us2k10--------
    rs37563631,2
    C,F,A,H--122108873(-) CTAAAT/CATCAT 1 -- us2k19Minor allele frequency- C:0.35NA WA CSA EA 370
    rs37563621,2
    C,F,H--122108890(-) TCTGAC/GTTCTA 1 -- us2k111Minor allele frequency- G:0.41NA WA CSA EA 373
    rs360361361,2
    C,F--122109100(+) AGAGTT/GTAGGC 1 -- us2k14Minor allele frequency- G:0.07NA 126
    rs68871011,2
    C,F,H--122109207(+) GCTGTG/ATTTGG 1 -- us2k123Minor allele frequency- A:0.33NS EA NA WA CSA 2346
    rs1911274801,2
    --122109242(+) TCCCTA/GAGGTG 1 -- us2k10--------
    rs1470646961,2
    --122109364(+) TTTTTA/GGCGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNX2 (122110691 - 122165803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SNX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830471CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNX2
    DNA2.0 Custom Variant and Variant Library Synthesis for SNX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605929    OMIM disorders: --


    Find genes that share disorders with SNX2           About GenesLikeMe


    Export disorders for SNX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNX2 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with SNX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of sorting nexin molecules and characterization of their association with receptors. (PubMed id 9819414)1, 2, 3, 9 Haft C.R.... Taylor S.I. (Mol. Cell. Biol. 1998)
    2. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. (PubMed id 17101778)1, 2, 9 Rojas R.... Bonifacino J.S. (Mol. Cell. Biol. 2007)
    3. The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. (PubMed id 11438682)1, 2, 9 Fuchs U.... Borkhardt A. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. (PubMed id 16179610)1, 2 Carlton J.G.... Cullen P.J. (J. Cell Sci. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance. (PubMed id 14596906)1, 2 Fuchs U.... Borkhardt A. (FEBS Lett. 2003)
    9. Abstrakt interacts with and regulates the expression of sorting nexin-2. (PubMed id 15690390)1, 9 Abdul-Ghani M....Ngsee J.K. (J. Cell. Physiol. 2005)
    10. A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)1, 9 Teasdale R.D.... Gleeson P.A. (Biochem. J. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6643 HGNC: 11173 AceView: SNX2 Ensembl:ENSG00000205302 euGenes: HUgn6643
    ECgene: SNX2 H-InvDB: SNX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNX2 gene:
    Search GeneIP for patents involving SNX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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