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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNX19 Gene

protein-coding   GIFtS: 50
GCID: GC11M130745

sorting nexin 19

 Explore 1 disease affiliated with
SNX19 via our new
 Human Malady Compendium 
Biological research products
for SNX19
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Sorting Nexin 191 2
CHET81 2
KIAA02541 3
Sorting Nexin-192

External Ids:    HGNC: 215321   Entrez Gene: 3999792   Ensembl: ENSG000001204517   UniProtKB: Q925433   

Export aliases for SNX19 gene to outside databases

Previous GC identifers: GC11M132258 GC11M130779 GC11M130283 GC11M130285 GC11M130250 GC11M126700


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SNX19_HUMAN, Q92543
Function: May be involved in several stages of intracellular trafficking (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNX19 gene promoter:
         HOXA9   HOXA9B   Nkx2-5   Arnt   c-Ets-1   E47   AREB6   Hand1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNX19 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNX19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q25   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q25

SNX19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX19 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M130745:  view genomic region     (about GC identifiers)

Start:
130,745,331 bp from pter      End:
130,786,404 bp from pter
Size:
41,074 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SNX19_HUMAN, Q92543 (See protein sequence)
Recommended Name: Sorting nexin-19  
Size: 992 amino acids; 108598 Da
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity)
Sequence caution: Sequence=BAA13384.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for SNX19: NX_Q92543

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92543

  • SNX19 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055573.2  
    ENSEMBL proteins: 
     ENSP00000265909   ENSP00000433699   ENSP00000413345   ENSP00000435122   ENSP00000432307  
     ENSP00000435390   ENSP00000443480   ENSP00000437982  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SNX19

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030659cytoplasmic vesicle membrane IEA--


    SNX19 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SNX19 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013996 PX_assoc_Snx13
     IPR013937 Sorting_nexin_C
     IPR001683 Phox
     IPR003114 Phox_assoc

    Graphical View of Domain Structure for InterPro Entry Q92543

    ProtoNet protein and cluster: Q92543

    3 Blocks protein families:
    IPB001683 Phox-like
    IPB003114 PX-associated
    IPB013937 Sorting nexin


    UniProtKB/Swiss-Prot: SNX19_HUMAN, Q92543
    Domain: The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3))
    (By similarity)
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 1 PXA domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SNX19_HUMAN, Q92543
    Function: May be involved in several stages of intracellular trafficking (By similarity)

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX19 (see all 12):
    hsa-miR-3650 hsa-miR-3132 hsa-miR-21 hsa-miR-1227 hsa-miR-590-5p hsa-miR-581 hsa-miR-4279 hsa-miR-608
    SwitchGear 3'UTR luciferase reporter plasmidSNX19 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX19

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16273344
    GO:0035091phosphatidylinositol binding IEA--


    SNX19 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SNX19:
     Lamellipodia cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNX19

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SNX19 (Q925431, 3 ENSP000002659094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRNQ168491, 3, ENSP000002957184EBI-728232,EBI-728153 I2D: score=3 STRING: ENSP00000295718
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007154cell communication IEA--
    GO:0015031protein transport IEA--


    SNX19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNX19
    Search CenterWatch for drugs/clinical trials and news about SNX19 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNX19 gene: 
    NM_014758.2  

    Unigene Cluster for SNX19:

    Sorting nexin 19
    Hs.444024  [show with all ESTs]
    Unigene Representative Sequence: NM_014758
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265909(uc010sce.2 uc010scf.2 uc010scg.2 uc001qgk.4)
    ENST00000527116 ENST00000526579 ENST00000534726 ENST00000426933 ENST00000533318
    ENST00000530330 ENST00000528555(uc009zcx.1) ENST00000530356 ENST00000524460
    ENST00000527451 ENST00000533214(uc001qgl.3) ENST00000531608 ENST00000539184
    ENST00000545537

    miRNA
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    OriGene 3'-UTR Clone: SNX19
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX19
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX19 (see all 12):
    hsa-miR-3650 hsa-miR-3132 hsa-miR-21 hsa-miR-1227 hsa-miR-590-5p hsa-miR-581 hsa-miR-4279 hsa-miR-608
    SwitchGear 3'UTR luciferase reporter plasmidSNX19 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF395843.1 AK292457.1 AK294731.1 AK295606.1 AK304809.1 AK308314.1 AK308628.1 AK309202.1 
    AK316414.1 AK316505.1 BC031620.1 D87443.1 

    13 DOTS entries:

    DT.217018  DT.86846812  DT.95074287  DT.100795018  DT.102935  DT.120685572  DT.65286827  DT.100718746 
    DT.100795017  DT.92018782  DT.95289709  DT.120685562  DT.91945415 

    24/302 AceView cDNA sequences (see all 302):

    BM992326 CD518943 BF115397 AI224127 AA459021 Z42637 BU181722 AL046468 
    N34955 CA418500 CD678150 BF447990 AI274045 AI888511 AL048615 CA388896 
    AI499759 CB267375 AI204416 AA826943 CA388895 AI284198 CD723897 AA831164 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SNX19 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b
    SP1:                                -                                                     -     -     -     -                                       
    SP2:                    -           -                                                                                                               
    SP3:                                                                                      -     -     -     -     -                                 
    SP4:                                                                                                  -     -                                       
    SP5:                                                                                                        -                                       


    ECgene alternative splicing isoforms for SNX19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNX19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATCCCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SNX19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNX19

    SOURCE GeneReport for Unigene cluster: Hs.444024
        SABiosciences Custom PCR Arrays for SNX19
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNX19 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SNX191 sorting nexin 19 63.69(n)
    59.49(a)
      419734  XM_003642598.1  XP_003642646.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNX196
    --
    55(a)
    1 ↔ 1
    GL343197.1(669153-701726)
    zebrafish
    (Danio rerio)
    Actinopterygii snx191 sorting nexin 19 57.11(n)
    51.05(a)
      568980  XM_692341.5  XP_697433.4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G159006
    AT1G152406
    phox (PX) domain-containing protein
    11(a)
    10(a)
    many ↔ many
    many ↔ many
    2(6927390-6932791)
    1(5243450-5248604)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    PX domain containing protein, putative, expressed
    11(a)
    10(a)
    many ↔ many
    many ↔ many
    11(2856637-2864666)
    5(28975904-28983664)


    ENSEMBL Gene Tree for SNX19 (if available)
    TreeFam Gene Tree for SNX19 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNX19 gene
    SNX132  SNX252  SNX142  
    1 SIMAP similar gene for SNX19 using alignment to 7 protein entries:     SNX19_HUMAN (see all proteins):
    DKFZp667I205

    SNX19 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for SNX19
    PGOHUM00000238835 PGOHUM00000257953 PGOHUM00000234882 PGOHUM00000258118


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/883 NCBI SNPs in SNX19 are shown (see all 883    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs79400271,2
    C,F,A,--130745591(+) TTGTGA/GGGTCG 1 -- ds50018Minor allele frequency- G:0.39NA WA CSA EA 367
    rs1931039571,2
    --130745671(+) CAACAC/TGGCAC 1 -- ds50010--------
    rs1854877771,2
    --130745678(+) GCACAG/TGTATA 1 -- ds50010--------
    rs112223711,2
    C,F,--130745719(+) TGTTCC/TCTAGA 1 -- ds50015Minor allele frequency- T:0.39NA EA 246
    rs1883301061,2
    --130745740(+) TAATAA/CTAATA 1 -- ds50010--------
    rs1808029891,2
    --130746029(+) AGTCAC/TGAGTA 1 -- ut310--------
    rs1856043481,2
    --130746030(+) GTCACA/GAGTAA 1 -- ut310--------
    rs1884565841,2
    --130746104(+) TTTTAA/TCACCC 1 -- ut310--------
    rs164121,2
    C,--130746130(+) CTTTT-/CCAG  
            
    TCTAC
    1 -- ut315Minor allele frequency- CCAG:0.46EU NA EA CSA 344
    rs10500781,2
    C,F,A,H,--130746146(-) TTGGTA/GGAGAG 1 -- ut3123Minor allele frequency- G:0.26MN NA NS EA WA 2670

    HapMap Linkage Disequilibrium report for SNX19 (130745331 - 130786404 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SNX19: --
    Human Gene Mutation Database (HGMD): SNX19

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX19
    DNA2.0 Custom Variant and Variant Library Synthesis for SNX19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SNX19 for disorders           About GeneDecksing

    1 disease for SNX19:    About MalaCards
    thyroiditis

    Human Genome Epidemiology (HuGE) Navigator: SNX19 (6 documents)

    Export disorders for SNX19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNX19 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SNX19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    2. The IA-2 interactome. (PubMed id 16273344)1, 9 Hu Y.F....Notkins A.L. (2005)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1 Luke M.M....Psaty B.M. (2009)
    5. Polymorphisms associated with both noncardioembolic s troke and coronary heart disease: vienna stroke registry. (PubMed id 19752551)1 Luke M.M....Mannhalter C. (2009)
    6. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1 Landa I....Robledo M. (2009)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    8. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1 Shiffman D....Psaty B.M. (2008)
    9. Five common gene variants identify elevated genetic risk for coronary heart disease. (PubMed id 18073581)1 Bare L.A....Boerwinkle E. (2007)
    10. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 399979 HGNC: 21532 AceView: LOC399979 Ensembl:ENSG00000120451 euGenes: HUgn399979
    ECgene: SNX19 H-InvDB: SNX19

    (According to HUGE)
    About This Section
    HUGE: KIAA0254

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNX19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNX19 gene:
    Search GeneIP for patents involving SNX19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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