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Aliases for SNX19 Gene

Aliases for SNX19 Gene

  • Sorting Nexin 19 2 3
  • Sorting Nexin-19 3
  • KIAA0254 4
  • CHET8 3

External Ids for SNX19 Gene

Previous GeneCards Identifiers for SNX19 Gene

  • GC11M132258
  • GC11M130779
  • GC11M130283
  • GC11M130285
  • GC11M130250
  • GC11M126700
  • GC11M130745

Summaries for SNX19 Gene

GeneCards Summary for SNX19 Gene

SNX19 (Sorting Nexin 19) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding.

UniProtKB/Swiss-Prot for SNX19 Gene

  • May be involved in several stages of intracellular trafficking.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX19 Gene

Genomics for SNX19 Gene

Regulatory Elements for SNX19 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNX19 Gene

Start:
130,875,436 bp from pter
End:
130,916,509 bp from pter
Size:
41,074 bases
Orientation:
Minus strand

Genomic View for SNX19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX19 Gene

Proteins for SNX19 Gene

  • Protein details for SNX19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92543-SNX19_HUMAN
    Recommended name:
    Sorting nexin-19
    Protein Accession:
    Q92543
    Secondary Accessions:
    • E9PKB9
    • Q8IV55

    Protein attributes for SNX19 Gene

    Size:
    992 amino acids
    Molecular mass:
    108598 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13384.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SNX19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX19 Gene

Proteomics data for SNX19 Gene at MOPED

Post-translational modifications for SNX19 Gene

  • Ubiquitination at Lys179
  • Modification sites at PhosphoSitePlus

Other Protein References for SNX19 Gene

No data available for DME Specific Peptides for SNX19 Gene

Domains for SNX19 Gene

Gene Families for SNX19 Gene

HGNC:
  • SNX :Sorting nexins

Protein Domains for SNX19 Gene

Suggested Antigen Peptide Sequences for SNX19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92543

UniProtKB/Swiss-Prot:

SNX19_HUMAN :
  • Q92543
Domain:
  • The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
  • Contains 1 PX (phox homology) domain.
  • Contains 1 PXA domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX19: view

Function for SNX19 Gene

Molecular function for SNX19 Gene

UniProtKB/Swiss-Prot Function: May be involved in several stages of intracellular trafficking.

Gene Ontology (GO) - Molecular Function for SNX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16273344
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX19: view

Phenotypes for SNX19 Gene

GenomeRNAi human phenotypes for SNX19:
genes like me logo Genes that share phenotypes with SNX19: view

Animal Model Products

CRISPR Products

miRNA for SNX19 Gene

miRTarBase miRNAs that target SNX19

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNX19 Gene

Localization for SNX19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX19 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX19 Gene COMPARTMENTS Subcellular localization image for SNX19 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SNX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19877062
GO:0016020 membrane --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with SNX19: view

Pathways for SNX19 Gene

SuperPathways for SNX19 Gene

No Data Available

Interacting Proteins for SNX19 Gene

Gene Ontology (GO) - Biological Process for SNX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation IMP 19877062
GO:0015031 protein transport --
GO:0030073 insulin secretion IGI 24843546
GO:1990502 dense core granule maturation IGI 24843546
genes like me logo Genes that share ontologies with SNX19: view

No data available for Pathways by source for SNX19 Gene

Transcripts for SNX19 Gene

Unigene Clusters for SNX19 Gene

Sorting nexin 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX19

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SNX19

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX19 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b
SP1: - - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6:
SP7: -
SP8:

Relevant External Links for SNX19 Gene

GeneLoc Exon Structure for
SNX19
ECgene alternative splicing isoforms for
SNX19

Expression for SNX19 Gene

mRNA expression in normal human tissues for SNX19 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX19 Gene

SOURCE GeneReport for Unigene cluster for SNX19 Gene Hs.444024

genes like me logo Genes that share expressions with SNX19: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX19 Gene

Orthologs for SNX19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNX19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX19 35
  • 99.16 (n)
  • 98.59 (a)
SNX19 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX19 35
  • 83.08 (n)
  • 81.85 (a)
SNX19 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX19 35
  • 85.07 (n)
  • 83.79 (a)
SNX19 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx19 35
  • 83.27 (n)
  • 82.15 (a)
Snx19 16
Snx19 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX19 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX19 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx19 35
  • 83.5 (n)
  • 83.05 (a)
chicken
(Gallus gallus)
Aves SNX19 35
  • 62.99 (n)
  • 58.99 (a)
SNX19 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX19 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx19 35
  • 63.62 (n)
  • 65.43 (a)
zebrafish
(Danio rerio)
Actinopterygii snx19a 35
  • 58.27 (n)
  • 54.57 (a)
snx19a 36
  • 44 (a)
OneToMany
snx19b 36
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for SNX19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX19 Gene

ENSEMBL:
Gene Tree for SNX19 (if available)
TreeFam:
Gene Tree for SNX19 (if available)

Paralogs for SNX19 Gene

Selected SIMAP similar genes for SNX19 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SNX19 Gene

genes like me logo Genes that share paralogs with SNX19: view

No data available for Paralogs for SNX19 Gene

Variants for SNX19 Gene

Sequence variations from dbSNP and Humsavar for SNX19 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1781 -- 130,910,120(+) ATCTC(C/T)GGAAT synonymous-codon, reference, nc-transcript-variant
rs16412 -- 130,876,235(+) CTTTT(-/CCAG)TCTAC utr-variant-3-prime
rs585512 -- 130,889,328(+) AAATG(G/T)GTGTT intron-variant
rs622567 -- 130,906,247(+) AACCC(A/C)ACTGA intron-variant
rs632154 -- 130,888,911(+) TGTTC(A/C)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX19 Gene

Variant ID Type Subtype PubMed ID
nsv898462 CNV Gain 21882294
esv273791 CNV Insertion 20981092
nsv552 CNV Loss 18451855

Relevant External Links for SNX19 Gene

HapMap Linkage Disequilibrium report
SNX19
Human Gene Mutation Database (HGMD)
SNX19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX19 Gene

Disorders for SNX19 Gene

Relevant External Links for SNX19

Genetic Association Database (GAD)
SNX19
Human Genome Epidemiology (HuGE) Navigator
SNX19
genes like me logo Genes that share disorders with SNX19: view

No data available for UniProtKB/Swiss-Prot for SNX19 Gene

Publications for SNX19 Gene

  1. The IA-2 interactome. (PMID: 16273344) Hu Y.F. … Notkins A.L. (Diabetologia 2005) 3 23
  2. Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor. (PMID: 19877062) Kan A. … Kawaguchi H. (Arthritis Rheum. 2009) 3 23
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  4. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PMID: 19730683) Landa I. … Robledo M. (PLoS Genet. 2009) 3 48
  5. Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry. (PMID: 19752551) Luke M.M. … Mannhalter C. (Cerebrovasc. Dis. 2009) 3 48

Products for SNX19 Gene

Sources for SNX19 Gene

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