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SNX19 Gene

protein-coding GIFtS: 56

GC11M130250

sorting nexin 19
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CHET8 ^¹, ²
DKFZp667I205 ^²
KIAA0254 ^¹, ², ³

Descriptions
sorting nexin 19 ^²

External Ids
HGNC: 21532¹
Entrez Gene: 399979²
UniProtKB: Q92543³
Ensembl: ENSG00000120451⁷

Search outside databases for aliases for SNX19 gene

Previous GC identifers: GC11M132258 GC11M130779 GC11M130283 GC11M130285

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: SNX19_HUMAN, Q92543

Function: May be involved in several stages of intracellular trafficking (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SNX19 gene

Entrez Gene cytogenetic band: 11q25 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q25

SNX19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M130250: (about GC identifiers)

Start:	130,250,976 bp from pter
End:	130,291,592 bp from pter
Size:	40,617 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SNX19_HUMAN, Q92543 (See protein sequence)

Recommended Name: Sorting nexin-19

Size: 992 amino acids; 108662 Da

REFSEQ proteins: NP_055573.2

ENSEMBL proteins:

ENSP00000265909

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SNX19)
	Human Recombinant Proteins from Abnova (SNX19)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for SNX19:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SNX19
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SNX19), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SNX19)
	Novus Biologicals Antibodies for SNX19

Assays for SNX19:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q92543

ProtoNet protein and cluster: Q92543

3 Blocks protein families:

IPB001683 Phox-like

IPB003114 PX-associated

IPB013937 Sorting nexin

UniProtKB/Swiss-Prot: SNX19_HUMAN, Q92543

Similarity: Belongs to the sorting nexin family

Similarity: Contains 1 PX (phox homology) domain

Similarity: Contains 1 PXA domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SNX19)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014758

Applied Biosystems Silencer® siRNAs for SNX19

Sigma-Aldrich siRNA for SNX19

Sigma-Aldrich shRNA for SNX19

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SNX19
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014758
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014758
untagged cDNA clones in CMV expression vector (see all 2): AL512699

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014758

UniProtKB/Swiss-Prot: SNX19_HUMAN, Q92543

Function: May be involved in several stages of intracellular trafficking (By similarity)

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16273344
GO:0035091	phosphoinositide binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for SNX19

1 Interacting protein for SNX19 (ENSP00000265909³ Q92543¹) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPRN	Q16849¹	STRING (score=.807) EBI-728232, EBI-728153

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007154	cell communication	IEA	--
GO:0015031	protein transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SNX19

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SNX19)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014758

Sigma-Aldrich siRNA for SNX19

Sigma-Aldrich shRNA for SNX19

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014758

REFSEQ mRNAs for SNX19 gene:

NM_014758.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014758

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014758
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014758
                                 untagged cDNA clones in CMV expression vector (see all 2): AL512699

Additional cDNA sequence:

AF395843.1 AK292457.1 AK294731.1 AK295606.1 AK304809.1 AK308314.1 AK308628.1 AK309202.1

AK316414.1 AK316505.1 BC031620.1 D87443.1

13 DOTS entries:

DT.217018 DT.86846812 DT.95074287 DT.100795018 DT.102935 DT.120685572 DT.65286827 DT.100718746

DT.100795017 DT.120685562 DT.92018782 DT.95289709 DT.91945415

24/302 AceView cDNA sequences (see all 302 ):

AI753487 BX502966 BI914661 AI304795 AI204416 AA629392 BF727045 BF447990

AA344375 AL512699 AA826943 CD655922 AL046468 CA388896 BF115397 CA388895

AI366514 BM128469 BI917098 N91947 CD518943 AL048175 AL048615 H97020

highest scoring ESTs for SNX19:

D87443 AA001592 AA001994 AA057078 AF395843 AI138401 AI247383 AI761099 AI807780 AI902938

Unigene Cluster for SNX19:

Sorting nexin 19

Hs.444024 [show with all ESTs]

Unigene Representative Sequence: NM_014758

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SNX19 (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12a	·	12b	·	12c	^	13a	·	13b
SP1:											-																		-		-		-		-
SP2:							-				-
SP3:																													-		-		-		-		-
SP4:																																	-		-
SP5:																																			-

About this scheme

ECgene alternative splicing isoforms for SNX19

1 Ensembl transcript including schematic representation:

ENST00000265909

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SNX19 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SNX19

¹ / ² / ³

10 probe-sets matching SNX19 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37045_at²^{, 3}	U95-A	1	1.00	1.00	0.54	1.14	D87443	0.80	1.00	0.91	1
82608_g_at²^{, 3}	U95-D	2	1.00	0.94	0.59	1.35	AI807780	0.60	1.00	0.82	1
82606_at²^{, 3}	U95-D	2	0.94	0.93	0.77	0.80	AI807780	0.60	1.00	0.82	1
82609_at²^{, 3}	U95-D	2	0.38	0.58	0.18	0.72	AI247383	0.60	1.00	0.82	1
202358_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BG434168	0.40	1.00	0.76	1
202359_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014758	0.40	1.00	0.76	1
202358_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202359_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554986_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1561710_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAATCCCTGT

SOURCE GeneReport for Unigene cluster: Hs.444024

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SNX19 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SNX19¹	--	sorting nexin 19	85.38(n) 84.19(a)	479391 XM_536529.2 XP_536529.2
chimpanzee (Pan troglodytes)	SNX19¹	--	sorting nexin 19	99.16(n) 98.59(a)	451670 XM_508865.2 XP_508865.2
cow (Bos taurus)	SNX19¹	--	sorting nexin 19	83.4(n) 82.24(a)	504649 XM_580805.3 XP_580805.2
rat (Rattus norvegicus)	Snx19¹	--	sorting nexin 19	83.03(n) 82.05(a)	315478 XM_235940.4 XP_235940.4
mouse (Mus musculus)	Snx19^{1, 5}	9⁵	sorting nexin 19^{1, 5}	83.5(n)¹ 82.35(a)¹	102607¹ NM_028874.2¹ NP_083150.1¹ AI195321⁵ AI506649⁵ (see all 17)

About this table Species with no ortholog for SNX19

ENSEMBL Gene Tree for SNX19

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SNX19 gene

SNX13² SNX25² SNX14²

Pseudogenes

3 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/380 NCBI SNPs in SNX19 are shown (see all 380 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 216)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2298566^1,2	A,C,F,H	130255852(+)	`GAAGCA/CGGAGG`	1	L/R	mis¹ ese³		13	EA EU WA NA	2520
--	rs3190331^1,2	A,C,F,H	130253341(-)	`AGTTGT/CATGCA`	1	--	ut3¹		13	EA MN EU WA NA	2662
--	rs3751037^1,2	A,C,F,H	130289964(-)	`CAAATC/GTTCGA`	1	V/L	mis¹		5	EA EU WA	1912
	rs6590520^1,2	A,C,F,H	130252596(+)	`CCCAGC/GCTTGC`	1	--	ut3¹		9	NA MN EA EU WA	1790
	rs4414223^1,2	A,C,F,H	130281734(+)	`CCACAC/TTGCCT`	1	N/S	mis¹		12	EA NA EU WA	1052
	rs1050071^1,2	A,C,F,H	130252441(-)	`AAGGTG/CTTTTG`	1	--	ut3¹		8	MN NA EA EU WA	1800
	rs1050078^1,2	A,C,F,H	130251356(-)	`TTGGTA/GGAGAG`	1	--	ut3¹		8	MN EU EA WA NA	746
--	rs1803424^1,2	A,C,F,H	130252205(-)	`CACTCG/AGAGGA`	1	--	ut3¹ ese³		7	EU EA WA NA	554
	rs11222372^1,2	C,F,H	130253437(+)	`GTAGCC/GTACTT`	1	--	ut3¹ ese³		8	EU EA WA	832
	rs1050075^1,2	F,H	130252110(-)	`AGCACA/C/GCAATT`	1	--	ut3¹ ese³		7	MN EA EU WA	1852

About this table

HapMap Linkage Disequilibrium images for SNX19 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Gene Mutation Database: SNX19
Human Genome Epidemiology Navigator: SNX19 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/11 PubMed articles for SNX19 gene (see all 11 ):

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{3, 4} Nagase T....Nomura N. (1996)
The IA-2 interactome. (PubMed id 16273344)^{1, 3} Hu Y.F....Notkins A.L. (2005)
Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)³ Luke M.M....Psaty B.M. (2009)
Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)³ Shiffman D....Psaty B.M. (2008)
Five common gene variants identify elevated genetic risk for coronary heart disease. (PubMed id 18073581)³ Bare L.A....Boerwinkle E. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)³ Brandenberger R.... Stanton L.W. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Sorting out the cellular functions of sorting nexins. (PubMed id 12461558)³ Worby C.A. and Dixon J.E. (2002)
Use of chromatin immunoprecipitation to clone novel E2F target promoters. (PubMed id 11564866)³ Weinmann A.S.... Farnham P.J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 399979	HGNC: 21532	AceView: LOC399979	Ensembl:ENSG00000120451	euGenes: HUgn399979
ECgene: SNX19	H-InvDB: SNX19

(According to HUGE)
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HUGE: KIAA0254

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for SNX19
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SNX19:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SNX19-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SNX19		Antibodies for SNX19
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SNX19		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Antibodies for SNX19

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SNX19 Gene at Home site.
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SNX19 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for SNX19

Summaries
for SNX19

Genomic Location
for SNX19

Proteins
for SNX19

Protein Domains/
Families
for SNX19

Gene Function
for SNX19

Pathways & Interactions
for SNX19

Drugs & Compounds
for SNX19

Transcripts
for SNX19

Expression
for SNX19

Orthologs
for SNX19

Paralogs
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SNPs/Variants
for SNX19

Disorders & Mutations
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Medical News
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Publications
for SNX19

Search for SNX19

Genome Databases showing SNX19

Other Databases showing SNX19

Specialized Databases showing SNX19

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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SNX19 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor SNX19

Summariesfor SNX19

Genomic Locationfor SNX19

Proteinsfor SNX19

Protein Domains/Familiesfor SNX19

Gene Functionfor SNX19

Pathways & Interactionsfor SNX19

Drugs & Compoundsfor SNX19

Transcriptsfor SNX19

Expression for SNX19

Orthologsfor SNX19

Paralogsfor SNX19

SNPs/Variantsfor SNX19

Disorders & Mutationsfor SNX19

Medical Newsfor SNX19

Publicationsfor SNX19

Search for SNX19

Genome Databases showing SNX19

Other Databases showing SNX19

Specialized Databases showing SNX19

Licensable Technologiesfor SNX19

Servicesfor SNX19

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SNX19

Summaries
for SNX19

Genomic Location
for SNX19

Proteins
for SNX19

Protein Domains/
Families
for SNX19

Gene Function
for SNX19

Pathways & Interactions
for SNX19

Drugs & Compounds
for SNX19

Transcripts
for SNX19

Expression
for SNX19

Orthologs
for SNX19

Paralogs
for SNX19

SNPs/Variants
for SNX19

Disorders & Mutations
for SNX19

Medical News
for SNX19

Publications
for SNX19

Licensable Technologies
for SNX19

Services
for SNX19