SNX18 Gene
protein-coding GIFtS: 49
GCID: GC05P053850
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sorting nexin 18(Previous name: sorting nexin associated golgi protein 1 )
(Previous symbol: SNAG1)
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Aliases
for SNX18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sorting Nexin 181 2 | | Sorting Nexin Associated Golgi Protein 11 2 | | SH3PXD3B1 2 3 | | Sorting Nexin-Associated Golgi Protein 12 3 | | SNAG11 2 3 | | SH3 And PX Domain-Containing Protein 3B2 3 | | SH3PX21 2 | | Sorting Nexin-182 |
Export aliases for SNX18 gene to outside databasesPrevious GC identifer: GC05P050787 |
Summaries
for SNX18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNX18:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiledcoil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding differentisoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SNX18_HUMAN, Q96RF0Function: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis viaclathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role inmacropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membranetubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane
Gene Wiki entry for SNX18 (SNAG1)
|
Genomic Views
for SNX18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNX18 gene promoter:
Max1 NF-E2 p45 NF-E2 c-Myc E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2SNX18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P053850: view genomic region
(about GC identifiers)
Start:
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53,813,589 bp from pter |
End:
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53,842,416 bp from pter |
Size:
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28,828 bases |
Orientation:
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plus strand |
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Proteins
for SNX18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNX18_HUMAN, Q96RF0 (See
protein sequence)Recommended Name: Sorting nexin-18 Size: 628 amino acids; 68894 Da
Subunit: Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1complex
Subcellular location: Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheralmembrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized atsites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized withclathrin and dynamin at the cell membrane. Transiently recruited to clathrin-coated pits at a late stage ofclathrin-coated vesicle formation
Secondary accessions: B4E2B3 H7BXX3 Q05BB3 Q0VG02Alternative splicing: 3 isoforms: Q96RF0-1 Q96RF0-2 Q96RF0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SNX18: NX_Q96RF0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96RF0
SNX18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001096045.1 NP_001138899.1 NP_443102.2
ENSEMBL proteins: ENSP00000370817 ENSP00000342276 ENSP00000317332
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010008 | endosome membrane |
IEA | -- | | GO:0012505 | endomembrane system |
IEA | -- | | GO:0030136 | colocalizes with clathrin-coated vesicle |
IDA | -- | | GO:0031234 | extrinsic to internal side of plasma membrane |
IDA | -- |
SNX18 for ontologies About GeneDecksing
SNX18 Antibody Products:
Assay Products for SNX18: |
Protein
Domains /
Families
for SNX18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX18 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96RF0ProtoNet protein and cluster: Q96RF0 1 Blocks protein family: IPB001683 Phox-like
UniProtKB/Swiss-Prot: SNX18_HUMAN, Q96RF0Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphateSimilarity: Belongs to the sorting nexin familySimilarity: Contains 1 BAR domainSimilarity: Contains 1 PX (phox homology) domainSimilarity: Contains 1 SH3 domain |
Function
for SNX18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNX18_HUMAN, Q96RF0Function: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis viaclathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role inmacropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membranetubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX18 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX18 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0035091 | phosphatidylinositol binding |
IEA | -- |
SNX18 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SNX18:
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Pathways & Interactions
for SNX18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX18
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for SNX18 (Q96RF02, 3 ENSP000003173324) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SNX18 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNX18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNX18
Search CenterWatch for drugs/clinical trials and news about SNX18
|
Transcripts
for SNX18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNX18 gene (3 alternative transcripts): NM_001102575.1 NM_001145427.1 NM_052870.2 Unigene Cluster for SNX18: Sorting nexin 18 Hs.432755 [show with all ESTs]Unigene Representative Sequence: NM_0011454273 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381410(uc003jpi.4) ENST00000343017(uc011cqg.2) ENST00000326277(uc003jpj.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX18 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX18 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SNX18 (NM_052870) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX18 |
Additional cDNA sequence: AF395536.1 AK022059.1 AK304195.1 BC060791.1 BC067860.1 BC117218.1 BC117220.1 5 DOTS entries: DT.311110 DT.97813204 DT.101960582 DT.40260251 DT.102827050 24/76 AceView cDNA sequences (see all 76): CB124515 BE351030 AA601509 BQ022586 BX472996 BM727909 BC067860 CB132834 AW386094 AA504492 BC060791 AI272193 BU742437 AI681573 CB143831 AA825651 AA668545 BF439089 AA865369 AA897576 BX107481 AA974856 AW386089 AK022059
GeneLoc Exon Structure
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Expression
for SNX18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTATCTTTT
About this image
See SNX18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX18
SOURCE GeneReport for Unigene cluster: Hs.432755
SABiosciences Custom PCR Arrays for SNX18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX18 |
Orthologs
for SNX18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNX18 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for SNX18 (if available)
TreeFam Gene Tree for SNX18 (if available) |
Paralogs
for SNX18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNX18 gene
- SNX92 SNX332
4 SIMAP similar genes for SNX18 using alignment to 1 protein entry: SNX18_HUMAN:SH3GL1 SH3GL2 SNX33 SNX9
SNX18 for paralogs About GeneDecksing
5/40 Pseudogenes.org Pseudogenes for SNX18 (see all 40)
PGOHUM00000248291 PGOHUM00000248504 PGOHUM00000234874 PGOHUM00000235014 PGOHUM00000234545
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Genomic Variants
for SNX18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX18 (53813589 - 53842416 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SNX18
1 CNV: 47880
1 Indel: 69064 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX18 |
|
Disorders
/ Diseases
for SNX18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SNX18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX18 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with SNX18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking. (PubMed id 18411244)1, 2, 9 Haberg K....Carlsson S.R. (2008)
- A proteomic screen reveals novel Fas ligand interacti ng proteins within nervous system Schwann cells. (PubMed id 17761170)1, 3, 9 Thornhill P.B....Desbarats J. (2007)
- SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane. (PubMed id 20427313)1, 2 Park J....Chang S. (2010)
- The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain. (PubMed id 20491914)1, 2 Baumann C.... Levy F. (2010)
- The Phox (PX) domain proteins and membrane traffic. (PubMed id 16782399)1, 3 Seet L.F. and Hong W. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genome-wide association study of antibody response to smallpox vaccine. (PubMed id 22542470)1 Ovsyannikova I.G....Poland G.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interaction between FIP5 and SNX18 regulates epitheli al lumen formation. (PubMed id 21969467)1 Willenborg C....Prekeris R. (2011)
- The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins. (PubMed id 21048941)2 Wang J.T....Teasdale R.D. (2010)
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External Searches for SNX18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNX18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNX18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNX18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX18 gene:
Search GeneIP for patents involving SNX18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNX18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SNX18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX18 |
|  |  |  | | | | ThermoFisher Antibodies for SNX18 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX18 |
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