SNX17 Gene
protein-coding GIFtS: 51
GCID: GC02P027593
|
|
sorting nexin 17
| |
Aliases
for SNX17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sorting Nexin 171 2 | | KIAA00641 3 | | Sorting Nexin-172 |
Export aliases for SNX17 gene to outside databasesPrevious GC identifers: GC02P027514 GC02P027685 GC02P027567 GC02P027505 GC02P027446 GC02P027335 |
Summaries
for SNX17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNX17:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiledcoil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domainof P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results inmultiple transcript variants encoding different isoforms. (provided by RefSeq, May 2012)
UniProtKB/Swiss-Prot: SNX17_HUMAN, Q15036Function: Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins.Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 andAPP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recyclesinternalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation.Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P))
Gene Wiki entry for SNX17
|
Genomic Views
for SNX17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNX17 gene promoter:
Pax-5 p300 Lmo2 AP-2gamma AREB6 CP2 AP-2beta AP-2alpha Pax-4a AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23-p22 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23-p22SNX17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P027593: view genomic region
(about GC identifiers)
Start:
|
27,593,389 bp from pter |
End:
|
27,599,995 bp from pter |
Size:
|
6,607 bases |
Orientation:
|
plus strand |
|
Proteins
for SNX17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNX17_HUMAN, Q15036 (See
protein sequence)Recommended Name: Sorting nexin-17 Size: 470 amino acids; 52901 Da
Subunit: Monomer. Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B (By similarity). Interactswith the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with KRIT1 (via N-terminus). Interactswith HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif)
Subcellular location: Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmicside
Sequence caution: Sequence=BAA06542.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from  and Proteopedia  for SNX17:3FOG (3D)
3LUI (3D)
Secondary accessions: B4DQM7 Q53HN7 Q6IAS3Alternative splicing: 2 isoforms: Q15036-1 Q15036-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SNX17: NX_Q15036
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15036
SNX17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001253988.1 NP_001253989.1 NP_001253990.1 NP_055563.1
ENSEMBL proteins: ENSP00000233575 ENSP00000399727 ENSP00000405399 ENSP00000401922 ENSP00000439208 ENSP00000441779 ENSP00000442567
Human Recombinant Protein Products for SNX17:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
SNX17 for ontologies About GeneDecksing
SNX17 Antibody Products:
Assay Products for SNX17: |
Protein
Domains /
Families
for SNX17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX17 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15036ProtoNet protein and cluster: Q15036 2 Blocks protein families: IPB000159 RA domain IPB001683 Phox-like
UniProtKB/Swiss-Prot: SNX17_HUMAN, Q15036Domain: The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required forassociation with endosomesDomain: The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, whilethe F1 module (Ras-associating) is responsible for interaction with membrane-bound HRASSimilarity: Belongs to the sorting nexin familySimilarity: Contains 1 PX (phox homology) domainSimilarity: Contains 1 Ras-associating domain |
Function
for SNX17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SNX17_HUMAN, Q15036Function: Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins.Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 andAPP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recyclesinternalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation.Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
SNX17 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SNX17 (NM_014748) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX17 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX17 |
|
Pathways & Interactions
for SNX17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNX17
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/19 Interacting proteins for SNX17 (Q150361, 2, 3 ENSP000002335754) via UniProtKB, MINT, STRING, and/or I2D (see all 19)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PLCG1 | P191741, 2, 3, ENSP000002440074 | EBI-1752620,EBI-79387 MINT-8112783 I2D:
score=3 STRING: ENSP00000244007 | | ABL1 | P005192, 3, ENSP000003614234 | MINT-8110767 I2D:
score=3 STRING: ENSP00000361423 | | FYN | P062412, 3, ENSP000003576564 | MINT-8111535 I2D:
score=3 STRING: ENSP00000357656 | | PIK3R1 | P279862, 3, ENSP000002743354 | MINT-8112255 I2D:
score=3 STRING: ENSP00000274335 | | SKIL | P127572, 3 | MINT-61672 I2D:
score=3 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
SNX17 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNX17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNX17
Search CenterWatch for drugs/clinical trials and news about SNX17
|
Transcripts
for SNX17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNX17 gene (4 alternative transcripts): NM_001267059.1 NM_001267060.1 NM_001267061.1 NM_014748.3 Unigene Cluster for SNX17: Sorting nexin 17 Hs.278569 [show with all ESTs]Unigene Representative Sequence: NR_04978212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000233575(uc010ylj.1 uc002rkg.1 uc010ylk.1 uc002rki.1 uc002rkh.1 uc010yll.1 uc010ylm.1 uc010yln.1 uc010ylo.1 uc010ylp.1)
ENST00000484886 ENST00000440760(uc010eza.1) ENST00000494893 ENST00000427123
ENST00000464279 ENST00000489402 ENST00000453453 ENST00000493711 ENST00000537606
ENST00000543024 ENST00000542478(uc010ylq.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNX17 (NM_014748) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX17 |
Additional cDNA sequence: AK129689.1 AK222543.1 AK293252.1 AK293464.1 AK295278.1 AK297054.1 AK298620.1 AK298856.1 AK298869.1 AK300144.1 AK300641.1 AK307122.1 AK308487.1 AK309640.1 AK316373.1 BC002524.1 BC002610.1 BC014620.2 BC021108.1 BC032320.1 BC050590.1 BT007167.1 CR457081.1 D31764.1 NR_049782.1 NR_049783.1 NR_049784.1 NR_049785.1 NR_049786.1 NR_049787.1 NR_049788.1 24/30 DOTS entries (see all 30): DT.100849520 DT.95223874 DT.448689 DT.100864265 DT.100739760 DT.100682848 DT.120979568 DT.92008771 DT.100858014 DT.120979259 DT.100859428 DT.91833857 DT.100863326 DT.91960585 DT.92463198 DT.120979279 DT.120979251 DT.40116650 DT.91699322 DT.100031575 DT.100682843 DT.100682849 DT.100682853 DT.100712483 24/838 AceView cDNA sequences (see all 838): BC014620 BU855741 BE378950 BM314003 BG678976 BU169964 BE888188 AW467712 AI200462 AI200044 BX402414 AW675514 BU075816 BM828476 F18494 AU124166 BM887988 AI364479 AI337339 BI489746 BI870711 AI685672 CR614181 BU855915
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for SNX17 (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | - | | | | | | - | | | | | |
| ExUns: | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SNX17
|
Expression
for SNX17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCAAAGGC
About this image
See SNX17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX17
SOURCE GeneReport for Unigene cluster: Hs.278569
SABiosciences Expression via Pathway-Focused PCR Array including SNX17: | Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX17
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX17 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX17 |
Orthologs
for SNX17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNX17 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SNX171 |
sorting nexin 17 |
77.11(n)
84.12(a) |
|
421990 XM_419999.3 XP_419999.3 |
African clawed frog
(Xenopus laevis) |
Amphibia |
snx17-prov2 |
sorting nexin 17 |
78.19(n) |
|
BC045228.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
snx171 |
sorting nexin 17 |
70.15(n)
76.76(a) |
|
568263 NM_001045157.3 NP_001038622.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG57341 , 3 |
CG57341 |
43(a)3
51.18(n)1
44.25(a)1 |
|
31B13
343541 NM_135509.31 NP_609353.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F17H10.33
snx-171 |
PhoX homologous domain, present in p47phox
and more3
Protein SNX-171 |
28(a)3
43.33(n)1
32.25(a)1 |
|
X(13151855-13154374)3
1846241 NM_001083293.11 NP_001076762.11 |
ENSEMBL Gene Tree for SNX17 (if available)
TreeFam Gene Tree for SNX17 (if available) |
Paralogs
for SNX17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNX17 gene
- SNX272 SNX312
3 SIMAP similar genes for SNX17 using alignment to 5 protein entries: SNX17_HUMAN (see all proteins):SNX31 SNX27 SNX24
SNX17 for paralogs About GeneDecksing
|
Genomic Variants
for SNX17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX17 (27593389 - 27599995 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNX17: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SNX17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNX17 for disorders About GeneDecksing
OMIM gene information: 605963
OMIM disorders: --
4  diseases for SNX17: About MalaCardscavernous malformation cerebral cavernous malformations cerebritis cholesterol
Export disorders for SNX17 gene to outside databases
|
Publications
for SNX17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX17 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with SNX17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functions of sorting nexin 17 domains and recognition motif for P- selectin trafficking. (PubMed id 15769472)1, 2, 3 Knauth P.... Bohnensack R. (2005)
- Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin- 17. (PubMed id 14739284)1, 2, 9 Burden J.J.... Soutar A.K. (2004)
- Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways. (PubMed id 19005208)1, 2, 9 Donoso M....Marzolo M.P. (2009)
- The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. (PubMed id 12169628)1, 3, 9 Stockinger W....Nimpf J. (2002)
- SNX17 protects integrins from degradation by sorting b etween lysosomal and recycling pathways. (PubMed id 22492727)1, 2 Steinberg F....Cullen P.J. (2012)
- Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1. (PubMed id 16712798)1, 2 Czubayko M....Bohnensack R. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin. (PubMed id 15121882)1, 2 Williams R....Cutler D.F. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
|
External Searches for SNX17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNX17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX17 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SNX17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SNX17 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SNX17 gene:
Search GeneIP for patents involving SNX17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SNX17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SNX17 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX17 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX17 | | | OriGene Protein Over-expression Lysate for SNX17 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SNX17 | | OriGene 3'-UTR Clone for SNX17 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX17 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX17 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SNX17 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SNX17 | | OriGene Custom Protein Services for SNX17 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX17 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX17 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX17 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX17 |
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| | | | Search Tocris compounds for SNX17 |
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 | | | SNX17 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX17 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SNX17 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX17 |
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