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Aliases for SNX17 Gene

Aliases for SNX17 Gene

  • Sorting Nexin 17 2 3
  • KIAA0064 4

External Ids for SNX17 Gene

Summaries for SNX17 Gene

Entrez Gene Summary for SNX17 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

GeneCards Summary for SNX17 Gene

SNX17 (Sorting Nexin 17) is a Protein Coding gene. GO annotations related to this gene include receptor binding and phosphatidylinositol binding. An important paralog of this gene is SNX27.

UniProtKB/Swiss-Prot for SNX17 Gene

  • Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

Gene Wiki entry for SNX17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX17 Gene

Genomics for SNX17 Gene

Genomic Location for SNX17 Gene

Start:
27,370,496 bp from pter
End:
27,377,533 bp from pter
Size:
7,038 bases
Orientation:
Plus strand

Genomic View for SNX17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX17 Gene

Regulatory Elements for SNX17 Gene

Proteins for SNX17 Gene

  • Protein details for SNX17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15036-SNX17_HUMAN
    Recommended name:
    Sorting nexin-17
    Protein Accession:
    Q15036
    Secondary Accessions:
    • B4DQM7
    • Q53HN7
    • Q6IAS3

    Protein attributes for SNX17 Gene

    Size:
    470 amino acids
    Molecular mass:
    52901 Da
    Quaternary structure:
    • Monomer. Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B (By similarity). Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with KRIT1 (via N-terminus). Interacts with HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif).
    SequenceCaution:
    • Sequence=BAA06542.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNX17 Gene

    Alternative splice isoforms for SNX17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX17 Gene

Proteomics data for SNX17 Gene at MOPED

Post-translational modifications for SNX17 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys63 and Lys241

No data available for DME Specific Peptides for SNX17 Gene

Domains for SNX17 Gene

Gene Families for SNX17 Gene

HGNC:
  • SNX :Sorting nexins

Protein Domains for SNX17 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SNX17_HUMAN
Domain:
  • The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes.:
    • Q15036
  • The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.:
    • Q15036
  • Contains 1 PX (phox homology) domain.:
    • Q15036
  • Contains 1 Ras-associating domain.:
    • Q15036
Family:
  • Belongs to the sorting nexin family.:
    • Q15036
genes like me logo Genes that share domains with SNX17: view

Function for SNX17 Gene

Molecular function for SNX17 Gene

UniProtKB/Swiss-Prot Function: Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

Gene Ontology (GO) - Molecular Function for SNX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding NAS 12169628
GO:0005515 protein binding IPI 16712798
GO:0008022 protein C-terminus binding IPI 11237770
GO:0035091 phosphatidylinositol binding IDA 16712798
GO:0050750 low-density lipoprotein particle receptor binding IDA 12169628
genes like me logo Genes that share ontologies with SNX17: view

miRNA for SNX17 Gene

miRTarBase miRNAs that target SNX17

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNX17 Gene

Localization for SNX17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX17 Gene

Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX17 Gene COMPARTMENTS Subcellular localization image for SNX17 gene
Compartment Confidence
cytosol 5
endosome 5
golgi apparatus 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SNX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005768 endosome IDA 23382219
GO:0005769 early endosome IDA 12169628
GO:0005794 Golgi apparatus IDA 10942595
GO:0005829 cytosol IDA 16712798
genes like me logo Genes that share ontologies with SNX17: view

Pathways for SNX17 Gene

SuperPathways for SNX17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006707 cholesterol catabolic process IC 12169628
GO:0006886 intracellular protein transport NAS 12169628
GO:0006898 receptor-mediated endocytosis IEA --
GO:0007165 signal transduction IEA --
GO:0016197 endosomal transport NAS 12169628
genes like me logo Genes that share ontologies with SNX17: view

No data available for Pathways by source for SNX17 Gene

Transcripts for SNX17 Gene

Unigene Clusters for SNX17 Gene

Sorting nexin 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8:
SP9: - - - - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - - - - -
SP13: - - - - - - -
SP14: - - - - -
SP15: - - -
SP16:
SP17: - -

ExUns: 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for SNX17 Gene

GeneLoc Exon Structure for
SNX17
ECgene alternative splicing isoforms for
SNX17

Expression for SNX17 Gene

mRNA expression in normal human tissues for SNX17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX17 Gene

SOURCE GeneReport for Unigene cluster for SNX17 Gene Hs.278569

genes like me logo Genes that share expressions with SNX17: view

Orthologs for SNX17 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX17 36
  • 99.5 (n)
  • 99.79 (a)
SNX17 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX17 36
  • 94.26 (n)
  • 98.94 (a)
SNX17 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX17 36
  • 94.82 (n)
  • 99.57 (a)
SNX17 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx17 36
  • 91.84 (n)
  • 98.51 (a)
Snx17 16
Snx17 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX17 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX17 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx17 36
  • 91.28 (n)
  • 98.09 (a)
chicken
(Gallus gallus)
Aves SNX17 36
  • 76.21 (n)
  • 82.65 (a)
SNX17 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia snx17-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia snx17 36
  • 72.71 (n)
  • 79.82 (a)
Str.7028 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12959 36
zebrafish
(Danio rerio)
Actinopterygii snx17 36
  • 70.15 (n)
  • 76.76 (a)
snx17 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011491 36
  • 50.96 (n)
  • 43.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5734 36
  • 51.74 (n)
  • 45.21 (a)
CG5734 37
  • 38 (a)
OneToMany
CG5734 38
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea snx-17 36
  • 43.39 (n)
  • 32.55 (a)
snx-17 37
  • 23 (a)
OneToMany
F17H10.3 38
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToOne
Species with no ortholog for SNX17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX17 Gene

ENSEMBL:
Gene Tree for SNX17 (if available)
TreeFam:
Gene Tree for SNX17 (if available)

Paralogs for SNX17 Gene

Paralogs for SNX17 Gene

Selected SIMAP similar genes for SNX17 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SNX17: view

Variants for SNX17 Gene

Sequence variations from dbSNP and Humsavar for SNX17 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1528533 -- 27,372,889(+) ATAGT(C/G)TACGA intron-variant, utr-variant-5-prime
rs3215365 -- 27,374,939(-) GCAGT(-/AA)GTCCT intron-variant
rs4665972 -- 27,375,230(+) GCCTC(C/T)CAGAT intron-variant
rs4665973 -- 27,375,288(+) CACCC(A/G)CCACG intron-variant
rs6547589 -- 27,373,528(+) CGGCT(A/C)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX17 Gene

Variant ID Type Subtype PubMed ID
nsv873754 CNV Loss 21882294
nsv833614 CNV Gain 17160897
dgv4072n71 CNV Loss 21882294
nsv873757 CNV Loss 21882294

Relevant External Links for SNX17 Gene

HapMap Linkage Disequilibrium report
SNX17

Disorders for SNX17 Gene

No disorders were found for SNX17 Gene.

No data available for UniProtKB/Swiss-Prot for SNX17 Gene

Publications for SNX17 Gene

  1. The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. (PMID: 12169628) Stockinger W. … Nimpf J. (EMBO J. 2002) 2 3 23
  2. Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin- 17. (PMID: 14739284) Burden J.J. … Soutar A.K. (J. Biol. Chem. 2004) 3 4 23
  3. Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y- dependent sorting motifs in different pathways. (PMID: 19005208) Donoso M. … Marzolo M.P. (Mol. Biol. Cell 2009) 3 4 23
  4. Functions of sorting nexin 17 domains and recognition motif for P- selectin trafficking. (PMID: 15769472) Knauth P. … Bohnensack R. (J. Mol. Biol. 2005) 2 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for SNX17 Gene

Sources for SNX17 Gene

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