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Aliases for SNX17 Gene

Aliases for SNX17 Gene

  • Sorting Nexin 17 2 3 5
  • KIAA0064 4

External Ids for SNX17 Gene

Previous GeneCards Identifiers for SNX17 Gene

  • GC02P027514
  • GC02P027685
  • GC02P027567
  • GC02P027505
  • GC02P027446
  • GC02P027593
  • GC02P027335

Summaries for SNX17 Gene

Entrez Gene Summary for SNX17 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

GeneCards Summary for SNX17 Gene

SNX17 (Sorting Nexin 17) is a Protein Coding gene. GO annotations related to this gene include receptor binding and phosphatidylinositol binding. An important paralog of this gene is SNX27.

UniProtKB/Swiss-Prot for SNX17 Gene

  • Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

Gene Wiki entry for SNX17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX17 Gene

Genomics for SNX17 Gene

Regulatory Elements for SNX17 Gene

Enhancers for SNX17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNX17 on UCSC Golden Path with GeneCards custom track

Promoters for SNX17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNX17 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX17 Gene

Chromosome:
2
Start:
27,370,496 bp from pter
End:
27,377,533 bp from pter
Size:
7,038 bases
Orientation:
Plus strand

Genomic View for SNX17 Gene

Genes around SNX17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX17 Gene

Proteins for SNX17 Gene

  • Protein details for SNX17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15036-SNX17_HUMAN
    Recommended name:
    Sorting nexin-17
    Protein Accession:
    Q15036
    Secondary Accessions:
    • B4DQM7
    • Q53HN7
    • Q6IAS3

    Protein attributes for SNX17 Gene

    Size:
    470 amino acids
    Molecular mass:
    52901 Da
    Quaternary structure:
    • Monomer. Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B (By similarity). Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with KRIT1 (via N-terminus). Interacts with HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif).
    SequenceCaution:
    • Sequence=BAA06542.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNX17 Gene

    Alternative splice isoforms for SNX17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX17 Gene

Proteomics data for SNX17 Gene at MOPED

Post-translational modifications for SNX17 Gene

  • Ubiquitination at Lys 63 and Lys 241
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SNX17 Gene

Domains & Families for SNX17 Gene

Gene Families for SNX17 Gene

Protein Domains for SNX17 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15036

UniProtKB/Swiss-Prot:

SNX17_HUMAN :
  • The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes.
  • The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.
  • Contains 1 PX (phox homology) domain.
  • Contains 1 Ras-associating domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX17: view

Function for SNX17 Gene

Molecular function for SNX17 Gene

UniProtKB/Swiss-Prot Function:
Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
genes like me logo Genes that share phenotypes with SNX17: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX17 Gene

Localization for SNX17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX17 Gene

Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX17 Gene COMPARTMENTS Subcellular localization image for SNX17 gene
Compartment Confidence
cytosol 5
endosome 5
golgi apparatus 5
nucleus 2
extracellular 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SNX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005769 early endosome IDA 12169628
GO:0005829 cytosol IDA 16712798
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0043234 protein complex IDA 23382219
genes like me logo Genes that share ontologies with SNX17: view

Pathways & Interactions for SNX17 Gene

SuperPathways for SNX17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006707 cholesterol catabolic process IC 12169628
GO:0030100 regulation of endocytosis NAS 12169628
GO:1990126 retrograde transport, endosome to plasma membrane IBA --
genes like me logo Genes that share ontologies with SNX17: view

No data available for Pathways by source and SIGNOR curated interactions for SNX17 Gene

Drugs & Compounds for SNX17 Gene

No Compound Related Data Available

Transcripts for SNX17 Gene

Unigene Clusters for SNX17 Gene

Sorting nexin 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8:
SP9: - - - - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - - - - -
SP13: - - - - - - -
SP14: - - - - -
SP15: - - -
SP16:
SP17: - -

ExUns: 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for SNX17 Gene

GeneLoc Exon Structure for
SNX17
ECgene alternative splicing isoforms for
SNX17

Expression for SNX17 Gene

mRNA expression in normal human tissues for SNX17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNX17 Gene

This gene is overexpressed in Lymph node (13.1) and Peripheral blood mononuclear cells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX17 Gene



SOURCE GeneReport for Unigene cluster for SNX17 Gene Hs.278569

genes like me logo Genes that share expression patterns with SNX17: view

Protein tissue co-expression partners for SNX17 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX17 Gene

Orthologs for SNX17 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNX17 35
  • 94.26 (n)
  • 98.94 (a)
SNX17 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX17 35
  • 94.82 (n)
  • 99.57 (a)
SNX17 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx17 35
  • 91.84 (n)
  • 98.51 (a)
Snx17 16
Snx17 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNX17 35
  • 99.5 (n)
  • 99.79 (a)
SNX17 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx17 35
  • 91.28 (n)
  • 98.09 (a)
oppossum
(Monodelphis domestica)
Mammalia SNX17 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX17 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX17 35
  • 76.21 (n)
  • 82.65 (a)
SNX17 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx17 35
  • 72.71 (n)
  • 79.82 (a)
Str.7028 35
African clawed frog
(Xenopus laevis)
Amphibia snx17-prov 35
zebrafish
(Danio rerio)
Actinopterygii snx17 35
  • 70.15 (n)
  • 76.76 (a)
snx17 36
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12959 35
fruit fly
(Drosophila melanogaster)
Insecta CG5734 37
  • 43 (a)
CG5734 35
  • 51.74 (n)
  • 45.21 (a)
CG5734 36
  • 38 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011491 35
  • 50.96 (n)
  • 43.68 (a)
worm
(Caenorhabditis elegans)
Secernentea F17H10.3 37
  • 28 (a)
snx-17 35
  • 43.39 (n)
  • 32.55 (a)
snx-17 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for SNX17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX17 Gene

ENSEMBL:
Gene Tree for SNX17 (if available)
TreeFam:
Gene Tree for SNX17 (if available)

Paralogs for SNX17 Gene

Paralogs for SNX17 Gene

(3) SIMAP similar genes for SNX17 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SNX17: view

Variants for SNX17 Gene

Sequence variations from dbSNP and Humsavar for SNX17 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3215365 -- 27,374,939(-) GCAGT(-/AA)GTCCT intron-variant
rs6547589 -- 27,373,528(+) CGGCT(A/C)ATTTT intron-variant
rs1528533 -- 27,372,889(+) ATAGT(C/G)TACGA intron-variant
rs34192774 -- 27,376,282(+) TCCTG(-/G)CCCTC intron-variant
rs4665972 -- 27,375,230(+) GCCTC(C/T)CAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX17 Gene

Variant ID Type Subtype PubMed ID
nsv873754 CNV Loss 21882294
nsv833614 CNV Gain 17160897
dgv4072n71 CNV Loss 21882294
nsv873757 CNV Loss 21882294

Variation tolerance for SNX17 Gene

Residual Variation Intolerance Score: 9.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SNX17 Gene

Disorders for SNX17 Gene

Relevant External Links for SNX17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX17

No disorders were found for SNX17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX17 Gene

Publications for SNX17 Gene

  1. Functions of sorting nexin 17 domains and recognition motif for P- selectin trafficking. (PMID: 15769472) Knauth P. … Bohnensack R. (J. Mol. Biol. 2005) 2 3 4 67
  2. The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. (PMID: 12169628) Stockinger W. … Nimpf J. (EMBO J. 2002) 2 3 23
  3. Adaptor protein sorting nexin 17 interacts with the scavenger receptor FEEL-1/stabilin-1 and modulates its expression on the cell surface. (PMID: 20226821) Adachi H. … Tsujimoto M. (Biochim. Biophys. Acta 2010) 3 23
  4. Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y- dependent sorting motifs in different pathways. (PMID: 19005208) Donoso M. … Marzolo M.P. (Mol. Biol. Cell 2009) 3 23
  5. Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes. (PMID: 18276590) Lee J. … Bu G. (J. Biol. Chem. 2008) 3 23

Products for SNX17 Gene

Sources for SNX17 Gene

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