Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SNX16 Gene

Aliases for SNX16 Gene

  • Sorting Nexin 16 2 3 5

External Ids for SNX16 Gene

Previous GeneCards Identifiers for SNX16 Gene

  • GC08M081590
  • GC08M082759
  • GC08M082435
  • GC08M082761
  • GC08M082874
  • GC08M078201
  • GC08M082711

Summaries for SNX16 Gene

Entrez Gene Summary for SNX16 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The function of this protein has not been determined. This gene results in three transcript variants encoding two distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX16 Gene

SNX16 (Sorting Nexin 16) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and phosphatidylinositol binding.

UniProtKB/Swiss-Prot for SNX16 Gene

  • May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX16 Gene

Genomics for SNX16 Gene

Regulatory Elements for SNX16 Gene

Enhancers for SNX16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNX16 on UCSC Golden Path with GeneCards custom track

Promoters for SNX16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNX16 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX16 Gene

Chromosome:
8
Start:
81,799,581 bp from pter
End:
81,842,866 bp from pter
Size:
43,286 bases
Orientation:
Minus strand

Genomic View for SNX16 Gene

Genes around SNX16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX16 Gene

Proteins for SNX16 Gene

  • Protein details for SNX16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57768-SNX16_HUMAN
    Recommended name:
    Sorting nexin-16
    Protein Accession:
    P57768
    Secondary Accessions:
    • A8K4D8
    • Q658L0
    • Q8N4U3

    Protein attributes for SNX16 Gene

    Size:
    344 amino acids
    Molecular mass:
    39167 Da
    Quaternary structure:
    • Homooligomer. Interacts with EGFR (By similarity).

    Alternative splice isoforms for SNX16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX16 Gene

Proteomics data for SNX16 Gene at MOPED

Post-translational modifications for SNX16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX16 Gene

Domains & Families for SNX16 Gene

Gene Families for SNX16 Gene

Protein Domains for SNX16 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57768

UniProtKB/Swiss-Prot:

SNX16_HUMAN :
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX16: view

Function for SNX16 Gene

Molecular function for SNX16 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.

Phenotypes for SNX16 Gene

GenomeRNAi human phenotypes for SNX16:
genes like me logo Genes that share phenotypes with SNX16: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX16 Gene

Localization for SNX16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX16 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX16 Gene COMPARTMENTS Subcellular localization image for SNX16 gene
Compartment Confidence
endosome 5
cytosol 3
lysosome 3
mitochondrion 3
vacuole 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SNX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IMP 12813048
GO:0031901 early endosome membrane IEA --
genes like me logo Genes that share ontologies with SNX16: view

Pathways & Interactions for SNX16 Gene

SuperPathways for SNX16 Gene

No Data Available

Interacting Proteins for SNX16 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000322652%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000322652 for SNX16 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for SNX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006622 protein targeting to lysosome IMP 12813048
genes like me logo Genes that share ontologies with SNX16: view

No data available for Pathways by source and SIGNOR curated interactions for SNX16 Gene

Drugs & Compounds for SNX16 Gene

No Compound Related Data Available

Transcripts for SNX16 Gene

Unigene Clusters for SNX16 Gene

Sorting nexin 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX16 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2: -
SP3: - - -

Relevant External Links for SNX16 Gene

GeneLoc Exon Structure for
SNX16
ECgene alternative splicing isoforms for
SNX16

Expression for SNX16 Gene

mRNA expression in normal human tissues for SNX16 Gene

Protein differential expression in normal tissues from HIPED for SNX16 Gene

This gene is overexpressed in Testis (35.3), Breast (10.1), and Lung (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX16 Gene



SOURCE GeneReport for Unigene cluster for SNX16 Gene Hs.492121

mRNA Expression by UniProt/SwissProt for SNX16 Gene

P57768-SNX16_HUMAN
Tissue specificity: Detected in placenta, lung, liver,heart and pancreas.
genes like me logo Genes that share expression patterns with SNX16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for SNX16 Gene

Orthologs for SNX16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNX16 35
  • 90.86 (n)
  • 88.63 (a)
SNX16 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX16 35
  • 90.99 (n)
  • 90.99 (a)
SNX16 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx16 35
  • 85.56 (n)
  • 84.01 (a)
Snx16 16
Snx16 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNX16 35
  • 99.61 (n)
  • 99.71 (a)
SNX16 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx16 35
  • 86.63 (n)
  • 84.59 (a)
oppossum
(Monodelphis domestica)
Mammalia SNX16 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX16 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX16 35
  • 74.14 (n)
  • 78.76 (a)
SNX16 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX16 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx16 35
  • 65.55 (n)
  • 65.35 (a)
zebrafish
(Danio rerio)
Actinopterygii snx16 35
  • 60.87 (n)
  • 71.15 (a)
snx16 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6410 37
  • 43 (a)
Snx16 36
  • 23 (a)
OneToOne
Species with no ortholog for SNX16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX16 Gene

ENSEMBL:
Gene Tree for SNX16 (if available)
TreeFam:
Gene Tree for SNX16 (if available)

Paralogs for SNX16 Gene

(2) SIMAP similar genes for SNX16 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SNX16: view

No data available for Paralogs for SNX16 Gene

Variants for SNX16 Gene

Sequence variations from dbSNP and Humsavar for SNX16 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs16919654 - 81,839,694(+) TTTCC(A/G)GATTT reference, missense
rs2029414 -- 81,802,918(-) AATAA(A/G)TTTTG intron-variant, downstream-variant-500B
rs2029415 -- 81,802,823(-) TCatt(A/T)ttaaa intron-variant, downstream-variant-500B
rs2029416 -- 81,802,092(-) AATTT(C/T)TTAAA intron-variant
rs7833384 -- 81,818,680(+) TCTTG(C/T)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX16 Gene

Variant ID Type Subtype PubMed ID
nsv831369 CNV Gain+Loss 17160897
nsv465722 CNV Gain 19166990
nsv6277 CNV Loss 18451855

Variation tolerance for SNX16 Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SNX16 Gene

Disorders for SNX16 Gene

Relevant External Links for SNX16

Genetic Association Database (GAD)
SNX16
Human Genome Epidemiology (HuGE) Navigator
SNX16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX16

No disorders were found for SNX16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX16 Gene

Publications for SNX16 Gene

  1. Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments. (PMID: 12813048) Hanson B.J. … Hong W. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study. (PMID: 19754948) Wolf C. … Weisschuh N. (BMC Med. Genet. 2009) 3 23
  3. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby C.A. … Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SNX16 Gene

Sources for SNX16 Gene

Content