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Aliases for SNX16 Gene

Aliases for SNX16 Gene

  • Sorting Nexin 16 2 3

External Ids for SNX16 Gene

Previous GeneCards Identifiers for SNX16 Gene

  • GC08M081590
  • GC08M082759
  • GC08M082435
  • GC08M082761
  • GC08M082874
  • GC08M078201
  • GC08M082711

Summaries for SNX16 Gene

Entrez Gene Summary for SNX16 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The function of this protein has not been determined. This gene results in three transcript variants encoding two distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX16 Gene

SNX16 (Sorting Nexin 16) is a Protein Coding gene. Diseases associated with SNX16 include low tension glaucoma. GO annotations related to this gene include identical protein binding and phosphatidylinositol binding.

UniProtKB/Swiss-Prot for SNX16 Gene

  • May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX16 Gene

Genomics for SNX16 Gene

Regulatory Elements for SNX16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNX16 Gene

Start:
81,799,581 bp from pter
End:
81,842,866 bp from pter
Size:
43,286 bases
Orientation:
Minus strand

Genomic View for SNX16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX16 Gene

Proteins for SNX16 Gene

  • Protein details for SNX16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57768-SNX16_HUMAN
    Recommended name:
    Sorting nexin-16
    Protein Accession:
    P57768
    Secondary Accessions:
    • A8K4D8
    • Q658L0
    • Q8N4U3

    Protein attributes for SNX16 Gene

    Size:
    344 amino acids
    Molecular mass:
    39167 Da
    Quaternary structure:
    • Homooligomer. Interacts with EGFR (By similarity).

    Alternative splice isoforms for SNX16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX16 Gene

Proteomics data for SNX16 Gene at MOPED

Post-translational modifications for SNX16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SNX16 Gene

Domains for SNX16 Gene

Gene Families for SNX16 Gene

HGNC:
  • SNX :Sorting nexins

Protein Domains for SNX16 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57768

UniProtKB/Swiss-Prot:

SNX16_HUMAN :
  • P57768
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX16: view

Function for SNX16 Gene

Molecular function for SNX16 Gene

UniProtKB/Swiss-Prot Function: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.

Gene Ontology (GO) - Molecular Function for SNX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035091 phosphatidylinositol binding IDA 12813048
GO:0042802 identical protein binding IPI 12813048
genes like me logo Genes that share ontologies with SNX16: view

Animal Model Products

CRISPR Products

miRNA for SNX16 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX16

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNX16 Gene

Localization for SNX16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX16 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX16 Gene COMPARTMENTS Subcellular localization image for SNX16 gene
Compartment Confidence
endosome 5
cytosol 3
mitochondrion 3
golgi apparatus 2
lysosome 2
vacuole 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SNX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005769 early endosome IDA 12813048
GO:0005770 late endosome IDA 12813048
GO:0031313 extrinsic component of endosome membrane IDA 12813048
GO:0031901 early endosome membrane IEA --
genes like me logo Genes that share ontologies with SNX16: view

Pathways for SNX16 Gene

SuperPathways for SNX16 Gene

No Data Available

Interacting Proteins for SNX16 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000322652%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000322652 for SNX16 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for SNX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006622 protein targeting to lysosome IMP 12813048
GO:0008333 endosome to lysosome transport IMP 12813048
GO:0045022 early endosome to late endosome transport IMP 12813048
genes like me logo Genes that share ontologies with SNX16: view

No data available for Pathways by source for SNX16 Gene

Transcripts for SNX16 Gene

Unigene Clusters for SNX16 Gene

Sorting nexin 16:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX16

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX16 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2: -
SP3: - - -

Relevant External Links for SNX16 Gene

GeneLoc Exon Structure for
SNX16
ECgene alternative splicing isoforms for
SNX16

Expression for SNX16 Gene

mRNA expression in normal human tissues for SNX16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SNX16 Gene

SOURCE GeneReport for Unigene cluster for SNX16 Gene Hs.492121

mRNA Expression by UniProt/SwissProt for SNX16 Gene

P57768-SNX16_HUMAN
Tissue specificity: Detected in placenta, lung, liver,heart and pancreas.
genes like me logo Genes that share expressions with SNX16: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SNX16 Gene

Orthologs for SNX16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX16 35
  • 99.61 (n)
  • 99.71 (a)
SNX16 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX16 35
  • 90.86 (n)
  • 88.63 (a)
SNX16 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX16 35
  • 90.99 (n)
  • 90.99 (a)
SNX16 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx16 35
  • 85.56 (n)
  • 84.01 (a)
Snx16 16
Snx16 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX16 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX16 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx16 35
  • 86.63 (n)
  • 84.59 (a)
chicken
(Gallus gallus)
Aves SNX16 35
  • 74.14 (n)
  • 78.76 (a)
SNX16 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX16 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx16 35
  • 65.55 (n)
  • 65.35 (a)
zebrafish
(Danio rerio)
Actinopterygii snx16 35
  • 60.87 (n)
  • 71.15 (a)
snx16 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Snx16 36
  • 23 (a)
OneToOne
CG6410 37
  • 43 (a)
Species with no ortholog for SNX16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX16 Gene

ENSEMBL:
Gene Tree for SNX16 (if available)
TreeFam:
Gene Tree for SNX16 (if available)

Paralogs for SNX16 Gene

Selected SIMAP similar genes for SNX16 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SNX16: view

No data available for Paralogs for SNX16 Gene

Variants for SNX16 Gene

Sequence variations from dbSNP and Humsavar for SNX16 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs774461 -- 81,819,171(+) AATTT(C/T)GAAAA intron-variant
rs774462 -- 81,820,905(+) CCTTC(C/T)TCCTC intron-variant
rs774463 -- 81,821,004(+) TAGTG(A/G)GTACC intron-variant
rs774464 -- 81,821,428(+) TTACC(A/G)AACAA intron-variant
rs774465 -- 81,821,896(+) agaaa(G/T)aatta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX16 Gene

Variant ID Type Subtype PubMed ID
nsv831369 CNV Gain+Loss 17160897
nsv465722 CNV Gain 19166990
nsv6277 CNV Loss 18451855

Relevant External Links for SNX16 Gene

HapMap Linkage Disequilibrium report
SNX16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX16 Gene

Disorders for SNX16 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SNX16 Gene including...

Search for SNX16 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SNX16 Gene

(3) Novoseek inferred disease relationships for SNX16 Gene

Disease -log(P) Hits PubMed IDs
bladder cancer 45.4 2
necrosis 11.6 2
tumors 0 2

Relevant External Links for SNX16

Genetic Association Database (GAD)
SNX16
Human Genome Epidemiology (HuGE) Navigator
SNX16
genes like me logo Genes that share disorders with SNX16: view

No data available for UniProtKB/Swiss-Prot for SNX16 Gene

Publications for SNX16 Gene

  1. Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments. (PMID: 12813048) Hanson B.J. … Hong W. (J. Biol. Chem. 2003) 2 3 4 23
  2. Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study. (PMID: 19754948) Wolf C. … Weisschuh N. (BMC Med. Genet. 2009) 3 23 48
  3. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby C.A. … Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002) 2 3
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SNX16 Gene

  • Addgene plasmids for SNX16

Sources for SNX16 Gene

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