SNX16 Gene
protein-coding GIFtS: 49
GCID: GC08M082761
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sorting nexin 16
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Aliases
for SNX16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sorting Nexin 161 2 | | Sorting Nexin-162 |
Export aliases for SNX16 gene to outside databasesPrevious GC identifers: GC08M081590 GC08M082759 GC08M082435 GC08M082874 GC08M078201 |
Summaries
for SNX16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNX16:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellular trafficking. The function of this protein has notbeen determined. This gene results in three transcript variants encoding two distinct isoforms. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: SNX16_HUMAN, P57768Function: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from earlyto late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGFsignaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome tothe cytoplasm
|
Genomic Views
for SNX16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNX16 gene promoter:
c-Fos AP-1 JunB Fra-1 FosB Gfi-1 GATA-2 c-Ets-1 IRF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21.13 Ensembl cytogenetic band: 8q21.13 HGNC cytogenetic band: 8q21.13SNX16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M082761: view genomic region
(about GC identifiers)
Start:
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82,711,816 bp from pter |
End:
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82,755,101 bp from pter |
Size:
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43,286 bases |
Orientation:
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minus strand |
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Proteins
for SNX16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNX16_HUMAN, P57768 (See
protein sequence)Recommended Name: Sorting nexin-16 Size: 344 amino acids; 39167 Da
Subunit: Homooligomer. Interacts with EGFR (By similarity)
Subcellular location: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane;Peripheral membrane protein; Cytoplasmic side. Cytoplasm (By similarity). Lysosome (By similarity)
Secondary accessions: A8K4D8 Q658L0 Q8N4U3Alternative splicing: 2 isoforms: P57768-1 P57768-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SNX16: NX_P57768
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P57768
SNX16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_071416.2 NP_690049.1 NP_690050.1
ENSEMBL proteins: ENSP00000322631 ENSP00000322652 ENSP00000428699 ENSP00000430038 ENSP00000428734 ENSP00000427876 ENSP00000428591 ENSP00000428289 ENSP00000430585 ENSP00000379621
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
SNX16 for ontologies About GeneDecksing
SNX16 Antibody Products:
Assay Products for SNX16: |
Protein
Domains /
Families
for SNX16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX16 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P57768ProtoNet protein and cluster: P57768 1 Blocks protein family: IPB001683 Phox-like
UniProtKB/Swiss-Prot: SNX16_HUMAN, P57768Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphateSimilarity: Belongs to the sorting nexin familySimilarity: Contains 1 PX (phox homology) domain |
Function
for SNX16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNX16_HUMAN, P57768Function: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from earlyto late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGFsignaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome tothe cytoplasm
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX16 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX16 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for SNX16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX16 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SNX16 for ontologies About GeneDecksing
|
Pathways & Interactions
for SNX16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX16
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SNX16 (ENSP000003226524) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SNX16 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNX16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNX16
Search CenterWatch for drugs/clinical trials and news about SNX16
|
Transcripts
for SNX16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNX16 gene (3 alternative transcripts): NM_022133.3 NM_152836.2 NM_152837.2 Unigene Cluster for SNX16: Sorting nexin 16 Hs.492121 [show with all ESTs]Unigene Representative Sequence: NM_02213311 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000353788 ENST00000345957 ENST00000520618 ENST00000519212 ENST00000523757
ENST00000521810 ENST00000519119 ENST00000519817 ENST00000518183 ENST00000521773
ENST00000396330(uc011lft.2 uc003ycn.3 uc003yco.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX16 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX16 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SNX16 (NM_152837) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX16 |
Additional cDNA sequence: AF305779.1 AK290903.1 AL833763.1 BC033630.1 6 DOTS entries: DT.455539 DT.100018648 DT.100751593 DT.92419975 DT.92419976 DT.120650355 24/51 AceView cDNA sequences (see all 51): AI373685 AA383790 AA361456 AA969394 BC033630 AA323037 AL833763 AA912868 BE551068 BG505147 BU687550 AI689976 BG700892 AI862797 NM_152836 CB268089 BP432084 CB997507 CB962009 AA744941 BG720962 BF032306 NM_022133 AA280333
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SNX16 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for SNX16
|
Expression
for SNX16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTAAGTTTT
About this image
See SNX16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX16
SOURCE GeneReport for Unigene cluster: Hs.492121
UniProtKB/Swiss-Prot: SNX16_HUMAN, P57768Tissue specificity: Detected in placenta, lung, liver,heart and pancreas
SABiosciences Custom PCR Arrays for SNX16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX16 |
Orthologs
for SNX16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNX16 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for SNX16 (if available)
TreeFam Gene Tree for SNX16 (if available) |
Paralogs
for SNX16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SNX16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX16 (82711816 - 82755101 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNX16: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX16 |
|
Disorders
/ Diseases
for SNX16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNX16 for disorders About GeneDecksing
OMIM gene information: 614903
OMIM disorders: --
6  diseases for SNX16: About MalaCardslow tension glaucoma urinary bladder cancer glaucoma hepatitis c
stomatitis hepatitis
1 disease from the University of Copenhagen DISEASES database for SNX16:Low tension glaucoma 3 Novoseek disease relationships for SNX16 gene About this table
Human Genome Epidemiology (HuGE) Navigator: SNX16 (1 document)
Export disorders for SNX16 gene to outside databases
|
Publications
for SNX16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX16 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with SNX16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments. (PubMed id 12813048)1, 2, 3, 9 Hanson B.J. and Hong W. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Sorting out the cellular functions of sorting nexins. (PubMed id 12461558)1, 3 Worby C.A. and Dixon J.E. (2002)
- Evaluation of nine candidate genes in patients with n ormal tension glaucoma: a case control study. (PubMed id 19754948)1, 9 Wolf C....Weisschuh N. (2009)
- A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
- Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospecti ve meta-analysis from the cohorts for heart and aging research in genomic epide miology (CHARGE) consortium. (PubMed id 20445134)1 Smith N.L....Vasan R.S. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for SNX16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNX16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNX16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNX16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX16 gene:
Search GeneIP for patents involving SNX16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNX16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for SNX16 | | OriGene Custom Protein Services for SNX16 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX16 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX16 |
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| | | | Search Tocris compounds for SNX16 |
| |  |  |  |  | | | | |
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 |
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 | | | SNX16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX16 |
|  |  |  | | | | ThermoFisher Antibodies for SNX16 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX16 |
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