Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SNX16 Gene

protein-coding   GIFtS: 55
GCID: GC08M082711

Sorting Nexin 16

  See SNX16-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sorting Nexin 161 2
Sorting Nexin-162

External Ids:    HGNC: 149801   Entrez Gene: 640892   Ensembl: ENSG000001044977   OMIM: 6149035   UniProtKB: P577683   

Export aliases for SNX16 gene to outside databases

Previous GC identifers: GC08M081590 GC08M082759 GC08M082435 GC08M082761 GC08M082874 GC08M078201


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SNX16 Gene:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which
is a phosphoinositide binding domain, and are involved in intracellular trafficking. The function of this protein
has not been determined. This gene results in three transcript variants encoding two distinct isoforms. (provided
by RefSeq, Jul 2008)

GeneCards Summary for SNX16 Gene:
SNX16 (sorting nexin 16) is a protein-coding gene. Diseases associated with SNX16 include low tension glaucoma. GO annotations related to this gene include phosphatidylinositol binding and identical protein binding.

UniProtKB/Swiss-Prot: SNX16_HUMAN, P57768
Function: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from
early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after
EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the
endosome to the cytoplasm




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNX16 gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   Gfi-1   GATA-2   c-Ets-1   IRF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNX16 promoter sequence
   Search Chromatin IP Primers for SNX16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNX16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

SNX16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX16 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M082711:  view genomic region     (about GC identifiers)

Start:
82,711,816 bp from pter      End:
82,755,101 bp from pter
Size:
43,286 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SNX16_HUMAN, P57768 (See protein sequence)
Recommended Name: Sorting nexin-16  
Size: 344 amino acids; 39167 Da
Subunit: Homooligomer. Interacts with EGFR (By similarity)
Secondary accessions: A8K4D8 Q658L0 Q8N4U3
Alternative splicing: 2 isoforms:  P57768-1   P57768-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SNX16: NX_P57768

Explore proteomics data for SNX16 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SNX16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_071416.2  NP_690049.1  NP_690050.1  

    ENSEMBL proteins: 
     ENSP00000322631   ENSP00000322652   ENSP00000428699   ENSP00000430038   ENSP00000428734  
     ENSP00000427876   ENSP00000428591   ENSP00000428289   ENSP00000430585   ENSP00000379621  

    SNX16 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for SNX16
    OriGene Protein Over-expression Lysate for SNX16
    OriGene MassSpec for SNX16
    OriGene Custom Protein Services for SNX16
    GenScript Custom Purified and Recombinant Proteins Services for SNX16
    Novus Biologicals SNX16 Protein
    Novus Biologicals SNX16 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNX16

     
    Search eBioscience for Proteins for SNX16 

    SNX16 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SNX16
    OriGene Custom Antibody Services for SNX16
    Novus Biologicals SNX16 Antibodies
    Abcam antibodies for SNX16
    Cloud-Clone Corp. Antibodies for SNX16
    ThermoFisher Antibodies for SNX16
    LSBio Antibodies in human, mouse, rat for SNX16

    SNX16 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SNX16
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNX16
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNX16
    Cloud-Clone Corp. CLIAs for SNX16
    Search eBioscience for ELISAs for SNX16 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SNX: Sorting nexins

    1 InterPro protein domain:
     IPR001683 Phox

    Graphical View of Domain Structure for InterPro Entry P57768

    ProtoNet protein and cluster: P57768

    1 Blocks protein domain: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SNX16_HUMAN, P57768
    Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain


    Find genes that share domains with SNX16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNX16_HUMAN, P57768
    Function: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from
    early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after
    EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the
    endosome to the cytoplasm

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035091phosphatidylinositol binding IDA12813048
    GO:0042802identical protein binding IPI12813048
         
    Find genes that share ontologies with SNX16           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNX16
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNX16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNX16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNX16

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNX16:
    hsa-mir-16-5p (MIRT031652), hsa-mir-96-5p (MIRT027924), hsa-mir-124-3p (MIRT022579), hsa-mir-103a-3p (MIRT027106)

    Block miRNA regulation of human, mouse, rat SNX16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX16 (see all 60):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-142-5p hsa-miR-379* hsa-miR-429 hsa-let-7d hsa-miR-106a hsa-miR-15a
    SwitchGear 3'UTR luciferase reporter plasmidSNX16 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNX16
    Predesigned siRNA for gene silencing in human, mouse, rat SNX16

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNX16

    Clone
    Products:
         
    OriGene clones in human, mouse for SNX16 (see all 17)
    OriGene ORF clones in mouse, rat for SNX16
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SNX16 (NM_152837)
    Sino Biological Human cDNA Clone for SNX16
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX16
    Addgene plasmids for SNX16 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNX16
    Browse ESI BIO Cell Lines and PureStem Progenitors for SNX16 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SNX16_HUMAN, P57768: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome
    membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (By similarity). Lysosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    mitochondrion3
    golgi apparatus2
    lysosome2
    vacuole2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IEA--
    GO:0005769early endosome IDA12813048
    GO:0005770late endosome IDA12813048
    GO:0031313extrinsic component of endosome membrane IDA12813048
    GO:0031901early endosome membrane IEA--

    Find genes that share ontologies with SNX16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNX16
    Interactions:

        Search GeneGlobe Interaction Network for SNX16

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SNX16 (ENSP000003226524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006622protein targeting to lysosome IMP12813048
    GO:0007154cell communication ----
    GO:0008333endosome to lysosome transport IMP12813048
    GO:0045022early endosome to late endosome transport IMP12813048

    Find genes that share ontologies with SNX16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNX16



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SNX16 gene (3 alternative transcripts): 
    NM_022133.3  NM_152836.2  NM_152837.2  

    Unigene Cluster for SNX16:

    Sorting nexin 16
    Hs.492121  [show with all ESTs]
    Unigene Representative Sequence: NM_022133
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000353788 ENST00000345957 ENST00000520618 ENST00000519212 ENST00000523757
    ENST00000521810 ENST00000519119 ENST00000519817 ENST00000518183 ENST00000521773
    ENST00000396330(uc011lft.2 uc003ycn.3 uc003yco.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNX16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX16 (see all 60):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-142-5p hsa-miR-379* hsa-miR-429 hsa-let-7d hsa-miR-106a hsa-miR-15a
    SwitchGear 3'UTR luciferase reporter plasmidSNX16 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNX16
    Predesigned siRNA for gene silencing in human, mouse, rat SNX16
    Clone
    Products:
         
    OriGene clones in human, mouse for SNX16 (see all 17)
    OriGene ORF clones in mouse, rat for SNX16
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SNX16 (NM_152837)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX16
    Addgene plasmids for SNX16 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNX16
    OriGene qSTAR qPCR primer pairs in human, mouse for SNX16
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNX16
      QuantiTect SYBR Green Assays in human, mouse, rat SNX16
      QuantiFast Probe-based Assays in human, mouse, rat SNX16

    Additional mRNA sequence: 

    AF305779.1 AK290903.1 AL833763.1 BC033630.1 

    6 DOTS entries:

    DT.455539  DT.100018648  DT.100751593  DT.92419975  DT.92419976  DT.120650355 

    Selected AceView cDNA sequences (see all 51):

    AA969394 AA361456 AL833763 AA323037 AA383790 BC033630 AI373685 AA912868 
    BG720962 BG700892 BE350017 AF305779 AA280333 CB962009 BI834174 CB268089 
    BP432084 NM_152837 NM_022133 BE551068 AI862797 BU687550 AA969318 BF032306 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SNX16    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                            
    SP2:        -                                                   
    SP3:                    -     -     -                           


    ECgene alternative splicing isoforms for SNX16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SNX16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAAGTTTT
    SNX16 Expression
    About this image


    SNX16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    SNX16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNX16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.492121

    UniProtKB/Swiss-Prot: SNX16_HUMAN, P57768
    Tissue specificity: Detected in placenta, lung, liver,heart and pancreas

        Custom PCR Arrays for SNX16
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SNX16
    OriGene qSTAR qPCR primer pairs in human, mouse for SNX16
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNX16
    QuantiTect SYBR Green Assays in human, mouse, rat SNX16
    QuantiFast Probe-based Assays in human, mouse, rat SNX16
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SNX16 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snx161 , 5 sorting nexin 161, 5 85.56(n)1
    84.01(a)1
      3 (2.66 cM)5
    747181  NM_029068.41  NP_083344.31 
     104178195 
    chicken
    (Gallus gallus)
    Aves SNX161 sorting nexin 16 74.14(n)
    78.76(a)
      420202  NM_001199488.1  NP_001186417.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNX166
    sorting nexin 16
    71(a)
    1 ↔ 1
    4(24357900-24381098)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia snx161 sorting nexin 16 65.55(n)
    65.35(a)
      550056  NM_001017302.3  NP_001017302.1 
    zebrafish
    (Danio rerio)
    Actinopterygii snx161 sorting nexin 16 60.87(n)
    71.15(a)
      402964  NM_205665.1  NP_991228.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64103   -- 43(a)   54E2   --


    ENSEMBL Gene Tree for SNX16 (if available)
    TreeFam Gene Tree for SNX16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SNX16 gene
    2 SIMAP similar genes for SNX16 using alignment to 8 protein entries:     SNX16_HUMAN (see all proteins):
    SGK3    PXK

    Find genes that share paralogs with SNX16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SNX16 (see all 929)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs748518111,2
    C,F--78246497(+) AAGAAC/GCTGGA 3 -- us2k13Minor allele frequency- G:0.12WA NA EA 358
    rs1850394511,2
    --78246544(+) AGCCAA/GAAGGT 3 -- us2k10--------
    rs1417340261,2
    C--82711421(+) GATAA-/TTTATC 3 -- ds50010--------
    rs1848590441,2
    --82711450(+) TAAATA/GTGCTG 3 -- ds50010--------
    rs134397951,2
    C,H--82711643(+) GACTTT/CCAAAA 3 -- ds50015Minor allele frequency- C:0.00NS EA NA 422
    rs1892749991,2
    --82711706(+) CATCTA/GTGAAA 3 -- ds50010--------
    rs1403681621,2
    --82711850(+) GAACAA/TAATAC 3 -- ut310--------
    rs732897351,2
    C,F--82712003(+) TGGTTC/TGCTTT 3 -- ut311Minor allele frequency- T:0.50WA 2
    rs1381070671,2
    --82712004(+) GGTTCA/GCTTTA 3 -- ut310--------
    rs1495277271,2
    --82712038(+) ATCTAA/GAATTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SNX16 (82711816 - 82755101 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SNX16:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6277CNV Loss18451855
    nsv465722CNV Gain19166990
    nsv831369CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNX16
    DNA2.0 Custom Variant and Variant Library Synthesis for SNX16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614903    OMIM disorders: --

    1 disease for SNX16:    
    About MalaCards
    low tension glaucoma

    1 disease from the University of Copenhagen DISEASES database for SNX16:
    Low tension glaucoma

    Find genes that share disorders with SNX16           About GenesLikeMe

    3 Novoseek inferred disease relationships for SNX16 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder cancer 45.4 2 17138150 (1), 16740760 (1)
    necrosis 11.6 2 17138150 (1), 16740760 (1)
    tumors 0 2 17138150 (1), 16740760 (1)

    Genetic Association Database (GAD): SNX16
    Human Genome Epidemiology (HuGE) Navigator: SNX16 (1 document)

    Export disorders for SNX16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SNX16 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SNX16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments. (PubMed id 12813048)1, 2, 3, 9 Hanson B.J. and Hong W. (J. Biol. Chem. 2003)
    2. Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study. (PubMed id 19754948)1, 4, 9 Wolf C....Weisschuh N. (BMC Med. Genet. 2009)
    3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (Carcinogenesis 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Sorting out the cellular functions of sorting nexins. (PubMed id 12461558)1, 3 Worby C.A. and Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002)
    6. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (Nat. Genet. 2013)
    7. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PubMed id 20445134)1 Smith N.L....Vasan R.S. (Circ Cardiovasc Genet 2010)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 64089 HGNC: 14980 AceView: SNX16 Ensembl:ENSG00000104497 euGenes: HUgn64089
    ECgene: SNX16 H-InvDB: SNX16

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SNX16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SNX16 gene:
    Search GeneIP for patents involving SNX16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SNX16   OriGene RNAi products in human, mouse, rat for SNX16  
     OriGene qPCR primer pairs and template standards for SNX16   OriGene Protein Over-expression Lysate for SNX16  
     OriGene MassSpec something-or-other for SNX16   OriGene clones in human, mouse for SNX16  
     OriGene qSTAR qPCR primer pairs in human, mouse for SNX16   OriGene Purified Protein for SNX16  
     OriGene ORF clones in mouse, rat for SNX16   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SNX16   OriGene Custom Protein Services for SNX16  

     
     
     Block miRNA regulation of human, mouse, rat SNX16 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SNX16
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNX16 Predesigned siRNA for gene silencing in human, mouse, rat SNX16
     QuantiFast Probe-based Assays in human, mouse, rat SNX16 QuantiTect SYBR Green Assays in human, mouse, rat SNX16
     Custom PCR Arrays for SNX16 Search Chromatin IP Primers for SNX16
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNX16  Search GeneGlobe Interaction Network for SNX16
     Regulatory tfbs in SNX16 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SNX16 GenScript cDNA clones with any tag delivered in your preferred vector for SNX16
     GenScript Custom Assay Services for SNX16 GenScript Custom overexpressing Cell Line Services for SNX16
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SNX16
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SNX16
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SNX16 antibodies
     SNX16 proteins
     SNX16 lysates
     Antibodies for SNX16
     See all of Abcam's Antibodies, Kits and Proteins for SNX16
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SNX16
     Antibodies for SNX16
     ELISAs for SNX16
     CLIAs for SNX16



     Browse ESI BIO Cell Lines and PureStem Progenitors for SNX16
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX16
     SwitchGear 3'UTR luciferase reporter plasmids for SNX16
     SwitchGear Promoter luciferase reporter plasmids for SNX16
     ThermoFisher Antibodies for SNX16
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX16
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNX16
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNX16
     LSBio Antibodies in human, mouse, rat for SNX16
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for SNX16
      Search eBioscience for proteins for SNX16
      Search eBioscience for elisas for SNX16
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SNX16 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4