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Aliases for SNX15 Gene

Aliases for SNX15 Gene

  • Sorting Nexin 15 2 3
  • Clone Iota Unknown Protein 3
  • HSAF001435 3

External Ids for SNX15 Gene

Previous GeneCards Identifiers for SNX15 Gene

  • GC11P067310
  • GC11P066463
  • GC11P064557
  • GC11P064538
  • GC11P064552
  • GC11P064782
  • GC11P061121
  • GC11P064794

Summaries for SNX15 Gene

Entrez Gene Summary for SNX15 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for SNX15 Gene

SNX15 (Sorting Nexin 15) is a Protein Coding gene. Among its related pathways are PDGFR-beta signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and phosphatidylinositol binding. An important paralog of this gene is RPS6KL1.

UniProtKB/Swiss-Prot for SNX15 Gene

  • May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.

Gene Wiki entry for SNX15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX15 Gene

Genomics for SNX15 Gene

Regulatory Elements for SNX15 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNX15 Gene

Chromosome:
11
Start:
65,027,408 bp from pter
End:
65,040,572 bp from pter
Size:
13,165 bases
Orientation:
Plus strand

Genomic View for SNX15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX15 Gene

Proteins for SNX15 Gene

  • Protein details for SNX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRS6-SNX15_HUMAN
    Recommended name:
    Sorting nexin-15
    Protein Accession:
    Q9NRS6
    Secondary Accessions:
    • E5KQS6
    • Q9NRS5

    Protein attributes for SNX15 Gene

    Size:
    342 amino acids
    Molecular mass:
    38291 Da
    Quaternary structure:
    • Homodimer. Interacts with SNX1, SNX2 and SNX4.

    Alternative splice isoforms for SNX15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX15 Gene

Proteomics data for SNX15 Gene at MOPED

Post-translational modifications for SNX15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX15 Gene

Antibody Products

No data available for DME Specific Peptides for SNX15 Gene

Domains & Families for SNX15 Gene

Gene Families for SNX15 Gene

Protein Domains for SNX15 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRS6

UniProtKB/Swiss-Prot:

SNX15_HUMAN :
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Contains 1 MIT domain.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX15: view

Function for SNX15 Gene

Molecular function for SNX15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.

Gene Ontology (GO) - Molecular Function for SNX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 NOT protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX15: view

Phenotypes for SNX15 Gene

GenomeRNAi human phenotypes for SNX15:
genes like me logo Genes that share phenotypes with SNX15: view

Animal Model Products

miRNA for SNX15 Gene

miRTarBase miRNAs that target SNX15

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX15 Gene

Localization for SNX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX15 Gene

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX15 Gene COMPARTMENTS Subcellular localization image for SNX15 gene
Compartment Confidence
cytosol 5
nucleus 4
endosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SNX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol NAS 11085978
GO:0016020 membrane NAS 11085978
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SNX15: view

Pathways & Interactions for SNX15 Gene

SuperPathways for SNX15 Gene

genes like me logo Genes that share pathways with SNX15: view

Pathways by source for SNX15 Gene

1 BioSystems pathway for SNX15 Gene

Gene Ontology (GO) - Biological Process for SNX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport NAS 11085978
GO:0007165 NOT signal transduction IBA --
genes like me logo Genes that share ontologies with SNX15: view

No data available for SIGNOR curated interactions for SNX15 Gene

Drugs & Compounds for SNX15 Gene

No Compound Related Data Available

Transcripts for SNX15 Gene

Unigene Clusters for SNX15 Gene

Sorting nexin 15:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: -
SP3: - - -
SP4:
SP5:

Relevant External Links for SNX15 Gene

GeneLoc Exon Structure for
SNX15
ECgene alternative splicing isoforms for
SNX15

Expression for SNX15 Gene

mRNA expression in normal human tissues for SNX15 Gene

Protein differential expression in normal tissues from HIPED for SNX15 Gene

This gene is overexpressed in Fetal Brain (15.8) and Peripheral blood mononuclear cells (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX15 Gene



SOURCE GeneReport for Unigene cluster for SNX15 Gene Hs.80132

mRNA Expression by UniProt/SwissProt for SNX15 Gene

Q9NRS6-SNX15_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SNX15: view

Protein tissue co-expression partners for SNX15 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SNX15 Gene

Orthologs for SNX15 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX15 36
  • 97 (a)
OneToOne
SNX15 35
  • 99.51 (n)
  • 99.71 (a)
mouse
(Mus musculus)
Mammalia Snx15 36
  • 87 (a)
OneToOne
Snx15 16
Snx15 35
  • 84.72 (n)
  • 88.1 (a)
oppossum
(Monodelphis domestica)
Mammalia SNX15 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX15 36
  • 89 (a)
OneToOne
SNX15 35
  • 88.17 (n)
  • 90.62 (a)
cow
(Bos Taurus)
Mammalia SNX15 36
  • 88 (a)
OneToOne
SNX15 35
  • 87.67 (n)
  • 91.12 (a)
rat
(Rattus norvegicus)
Mammalia Snx15 35
  • 83.63 (n)
  • 86.9 (a)
lizard
(Anolis carolinensis)
Reptilia SNX15 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx15 35
  • 55.27 (n)
  • 53.23 (a)
zebrafish
(Danio rerio)
Actinopterygii snx15 36
  • 37 (a)
OneToOne
snx15 35
  • 58.37 (n)
  • 54.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7156 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rskd-1 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
OneToMany
Species with no ortholog for SNX15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX15 Gene

ENSEMBL:
Gene Tree for SNX15 (if available)
TreeFam:
Gene Tree for SNX15 (if available)

Paralogs for SNX15 Gene

Paralogs for SNX15 Gene

(1) SIMAP similar genes for SNX15 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SNX15: view

Variants for SNX15 Gene

Sequence variations from dbSNP and Humsavar for SNX15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_052478 -

Structural Variations from Database of Genomic Variants (DGV) for SNX15 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
dgv1174n71 CNV Loss 21882294

Variation tolerance for SNX15 Gene

Residual Variation Intolerance Score: 89.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.79; 73.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX15 Gene

HapMap Linkage Disequilibrium report
SNX15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX15 Gene

Disorders for SNX15 Gene

Relevant External Links for SNX15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX15
genes like me logo Genes that share disorders with SNX15: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX15 Gene

Publications for SNX15 Gene

  1. Structural characterization of the MIT domain from human Vps4b. (PMID: 16018968) Takasu H. … Hiroaki H. (Biochem. Biophys. Res. Commun. 2005) 23 67
  2. A clinical, genetic and candidate gene study of Silver syndrome, a complicated form of hereditary spastic paraplegia. (PMID: 15372247) Warner T.T. … Crosby A.H. (J. Neurol. 2004) 23 67
  3. Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking. (PMID: 11208079) Barr V.A. … Haft C.R. (Traffic 2000) 2 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for SNX15 Gene

Sources for SNX15 Gene

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