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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNX14 Gene

protein-coding   GIFtS: 46
GCID: GC06M086215

sorting nexin 14

 Explore 1 disease affiliated with
SNX14 via our new
 Human Malady Compendium 
Biological research products
for SNX14
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Sorting Nexin 141 2
RGS-PX21 2
Sorting Nexin-142

External Ids:    HGNC: 149771   Entrez Gene: 572312   Ensembl: ENSG000001353177   UniProtKB: Q9Y5W73   

Export aliases for SNX14 gene to outside databases

Previous GC identifers: GC06U990242 GC06M086181 GC06M086210 GC06M086271 GC06M083439


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNX14:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a
phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein also contains a
regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory
molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Two transcript
variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SNX14_HUMAN, Q9Y5W7
Function: May be involved in several stages of intracellular trafficking (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNX14 gene promoter:
         HOXA9   STAT5B   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   HNF-3beta   POU3F2   C/EBPalpha   MEF-2A   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNX14 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNX14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.3   Ensembl cytogenetic band:  6q14.3   HGNC cytogenetic band: 6q15

SNX14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX14 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M086215:  view genomic region     (about GC identifiers)

Start:
86,215,214 bp from pter      End:
86,303,874 bp from pter
Size:
88,661 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SNX14_HUMAN, Q9Y5W7 (See protein sequence)
Recommended Name: Sorting nexin-14  
Size: 946 amino acids; 110182 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=CAI20444.1; Type=Erroneous gene model prediction; Sequence=CAI20445.1; Type=Erroneous gene
model prediction;
Secondary accessions: B4DI55 Q4VBR3 Q5TCF9 Q5TCG0 Q6NUI7 Q6PI37 Q9BSD1
Alternative splicing: 4 isoforms:  Q9Y5W7-1   Q9Y5W7-2   Q9Y5W7-3   Q9Y5W7-4   

Explore the universe of human proteins at neXtProt for SNX14: NX_Q9Y5W7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5W7

  • SNX14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_065201.1  NP_722523.1  

    ENSEMBL proteins: 
     ENSP00000257769   ENSP00000313121   ENSP00000420938   ENSP00000427380   ENSP00000358641  
     ENSP00000422814   ENSP00000425630   ENSP00000391981   ENSP00000358649   ENSP00000424302  
     ENSP00000425387   ENSP00000426806  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SNX14

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    SNX14 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SNX14 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013937 Sorting_nexin_C
     IPR001683 Phox
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam
     IPR003114 Phox_assoc

    Graphical View of Domain Structure for InterPro Entry Q9Y5W7

    ProtoNet protein and cluster: Q9Y5W7

    3 Blocks protein families:
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB001683 Phox-like
    IPB013937 Sorting nexin


    UniProtKB/Swiss-Prot: SNX14_HUMAN, Q9Y5W7
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 1 PXA domain
    Similarity: Contains 1 RGS domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SNX14_HUMAN, Q9Y5W7
    Function: May be involved in several stages of intracellular trafficking (By similarity)

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035091phosphatidylinositol binding IEA--


    SNX14 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX14

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SNX14 (Q9Y5W73 ENSP000003131214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNF1AP208233I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007154cell communication IEA--
    GO:0015031protein transport IEA--
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--


    SNX14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNX14
    Search CenterWatch for drugs/clinical trials and news about SNX14 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNX14 gene (2 alternative transcripts): 
    NM_020468.3  NM_153816.3  

    Unigene Cluster for SNX14:

    Sorting nexin 14
    Hs.485871  [show with all ESTs]
    Unigene Representative Sequence: AK095380
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000346348(uc003pks.3) ENST00000314673(uc011dzg.2 uc003pkr.3 uc003pkt.3)
    ENST00000513865 ENST00000474645 ENST00000505648 ENST00000508980(uc003pkq.3)
    ENST00000369627 ENST00000503491(uc003pkp.3) ENST00000508658 ENST00000515216
    ENST00000418862 ENST00000369635 ENST00000503608 ENST00000506182 ENST00000514801
    ENST00000504191 ENST00000509338 ENST00000514419

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    hsa-miR-922 hsa-miR-513a-3p hsa-miR-205* hsa-miR-548n
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF121863.1 AJ420561.1 AK000362.1 AK095380.1 AK125063.1 AK226097.1 AK293821.1 AK295417.1 
    AY044865.1 BC005110.1 BC046520.2 BC068589.1 BC095419.1 

    24 DOTS entries:

    DT.215001  DT.92437092  DT.101983722  DT.70103081  DT.121330173  DT.92437097  DT.121330088  DT.100008084 
    DT.121330095  DT.205961  DT.97844377  DT.121330218  DT.121330220  DT.75115257  DT.100889083  DT.121330079 
    DT.40206854  DT.100840959  DT.100889091  DT.91642298  DT.91749441  DT.95264413  DT.97823974  DT.99982652 

    24/467 AceView cDNA sequences (see all 467):

    BM982264 AA594467 AA629942 AA418952 BG026689 AA363926 AA738345 BG547215 
    BF732338 AA432174 AA677426 BG286350 AW152367 BE745818 AF121863 BF062305 
    AA928471 AI224391 BM545943 BX643629 BG527027 AI697653 BM458051 BQ945048 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SNX14 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ·
    SP1:                                                                                                                                -     -                     
    SP2:                    -     -                                   -                                                                       -                     
    SP3:                    -     -                       -     -     -                                                                 -     -                     
    SP4:                          -     -                             -                                                                 -     -                     
    SP5:                    -     -                                   -                                                                                             

    ExUns: 21c ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b
    SP1:                                      -                       -                           
    SP2:                                      -                       -                           
    SP3:                                      -                       -                           
    SP4:                                      -                       -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for SNX14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNX14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTTCATTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SNX14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNX14

    SOURCE GeneReport for Unigene cluster: Hs.485871
        SABiosciences Custom PCR Arrays for SNX14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNX14 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SNX141 sorting nexin 14 81.83(n)
    88.76(a)
      421832  NM_001039289.1  NP_001034378.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNX146
    --
    82(a)
    1 ↔ 1
    1(176839851-176884933)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.210992 Xenopus laevis transcribed sequence with weak similarity more 77.61(n)    BX845195.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.257422 Transcribed sequence with weak similarity to protein more 71.47(n)    CK147430.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0123771 AGAP012377-PA 44.23(n)
    30.71(a)
      1280336  XM_320181.4  XP_320181.3 
    worm
    (Caenorhabditis elegans)
    Secernentea snx-141 Protein SNX-14 41.21(n)
    28.97(a)
      174997  NM_064443.4  NP_496844.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G159006
    AT1G152406
    phox (PX) domain-containing protein
    13(a)
    12(a)
    many ↔ many
    many ↔ many
    2(6927390-6932791)
    1(5243450-5248604)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    PX domain containing protein, putative, expressed
    12(a)
    10(a)
    many ↔ many
    many ↔ many
    11(2856637-2864666)
    5(28975904-28983664)


    ENSEMBL Gene Tree for SNX14 (if available)
    TreeFam Gene Tree for SNX14 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNX14 gene
    SNX132  SNX192  SNX252  
    1 SIMAP similar gene for SNX14 using alignment to 9 protein entries:     SNX14_HUMAN (see all proteins):
    PXK

    SNX14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1330 NCBI SNPs in SNX14 are shown (see all 1330    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113165711,2
    C--83492935(+) ACAGG-/AAAAAA 1 -- int1 trp32Minor allele frequency- A:0.00NA CSA 4
    rs175312181,2
    C,F,--86214781(+) CAGTGT/CTCTCA 2 -- ds50013Minor allele frequency- C:0.01NA 140
    rs1511396811,2
    --86214862(+) AACCTA/CATGCA 2 -- ds50010--------
    rs1406210741,2
    --86215109(+) GAAACC/TTAGAG 2 -- ds50010--------
    rs1458742481,2
    --86215178(+) AACCCA/GTCAGA 2 -- ds50010--------
    rs1850209581,2
    --86215316(+) TAACTC/GTAAGA 2 -- ut310--------
    rs93510621,2
    C,F,H,--86215343(+) CTGTTT/CCTCCA 2 -- ut31 ese34Minor allele frequency- C:0.01NS EA 418
    rs412716231,2
    C,F,--86215383(+) CAATAC/TGAAGT 2 -- ut311Minor allele frequency- T:0.02NA 120
    rs1422007531,2
    C,--86215430(+) AATTT-/TCTCTTT 2 -- ut310--------
    rs1413293781,2
    --86215480(+) ATTTGA/GATCAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SNX14 (86215214 - 86303874 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SNX14
         1 CNV: 52014

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SNX14 for disorders           About GeneDecksing

    1 disease for SNX14:    About MalaCards
    neuronitis


    Export disorders for SNX14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNX14 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SNX14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)1, 2, 3 Teasdale R.D.... Gleeson P.A. (2001)
    2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The Phox homology (PX) domain, a new player in phosph oinositide signalling. (PubMed id 11736640)1, 3 Xu Y....Hong W. (2001)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57231 HGNC: 14977 AceView: SYNCRIPandSNX14 Ensembl:ENSG00000135317 euGenes: HUgn57231
    ECgene: SNX14 H-InvDB: SNX14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNX14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNX14 gene:
    Search GeneIP for patents involving SNX14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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