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Aliases for SNX14 Gene

Aliases for SNX14 Gene

  • Sorting Nexin 14 2 3
  • Sorting Nexin-14 3
  • RGS-PX2 3

External Ids for SNX14 Gene

Summaries for SNX14 Gene

Entrez Gene Summary for SNX14 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for SNX14 Gene

SNX14 (Sorting Nexin 14) is a Protein Coding gene. Diseases associated with SNX14 include intellectual disability-coarse face-macrocephaly-cerebellar hypotrophy syndrome. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX13.

UniProtKB/Swiss-Prot for SNX14 Gene

  • Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX14 Gene

Genomics for SNX14 Gene

Genomic Location for SNX14 Gene

Start:
85,505,496 bp from pter
End:
85,594,156 bp from pter
Size:
88,661 bases
Orientation:
Minus strand

Genomic View for SNX14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX14 Gene

Proteins for SNX14 Gene

  • Protein details for SNX14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5W7-SNX14_HUMAN
    Recommended name:
    Sorting nexin-14
    Protein Accession:
    Q9Y5W7
    Secondary Accessions:
    • B4DI55
    • Q4VBR3
    • Q5TCF9
    • Q5TCG0
    • Q6NUI7
    • Q6PI37
    • Q9BSD1

    Protein attributes for SNX14 Gene

    Size:
    946 amino acids
    Molecular mass:
    110182 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI20444.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20445.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNX14 Gene

    Alternative splice isoforms for SNX14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX14 Gene

Proteomics data for SNX14 Gene at MOPED

Post-translational modifications for SNX14 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys196, Lys213, and Lys756

No data available for DME Specific Peptides for SNX14 Gene

Domains for SNX14 Gene

Gene Families for SNX14 Gene

HGNC:
  • SNX :Sorting nexins

UniProtKB/Swiss-Prot:

SNX14_HUMAN
Domain:
  • Contains 1 PX (phox homology) domain.:
    • Q9Y5W7
  • Contains 1 PXA domain.:
    • Q9Y5W7
  • Contains 1 RGS domain.:
    • Q9Y5W7
Family:
  • Belongs to the sorting nexin family.:
    • Q9Y5W7
genes like me logo Genes that share domains with SNX14: view

Function for SNX14 Gene

Molecular function for SNX14 Gene

UniProtKB/Swiss-Prot Function: Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking.

Gene Ontology (GO) - Molecular Function for SNX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX14: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SNX14 Gene

Localization for SNX14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX14 Gene

Membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX14 Gene COMPARTMENTS Subcellular localization image for SNX14 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SNX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with SNX14: view

Pathways for SNX14 Gene

SuperPathways for SNX14 Gene

No Data Available

Interacting Proteins for SNX14 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000313121%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000257555%0d%0a
Selected Interacting proteins: ENSP00000313121 Q9Y5W7-SNX14_HUMAN for SNX14 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SNX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway --
GO:0015031 protein transport IEA --
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with SNX14: view

No data available for Pathways by source for SNX14 Gene

Transcripts for SNX14 Gene

Unigene Clusters for SNX14 Gene

Sorting nexin 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ·
SP1: - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - -
SP6:
SP7:
SP8:

ExUns: 21c ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SNX14 Gene

GeneLoc Exon Structure for
SNX14
ECgene alternative splicing isoforms for
SNX14

Expression for SNX14 Gene

mRNA expression in normal human tissues for SNX14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX14 Gene

SOURCE GeneReport for Unigene cluster for SNX14 Gene Hs.485871

genes like me logo Genes that share expressions with SNX14: view

Orthologs for SNX14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX14 36
  • 99.89 (n)
  • 100 (a)
SNX14 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX14 36
  • 93.27 (n)
  • 96.19 (a)
SNX14 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX14 36
  • 94.24 (n)
  • 97.12 (a)
SNX14 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx14 36
  • 90.07 (n)
  • 97.44 (a)
Snx14 16
Snx14 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX14 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX14 37
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX14 36
  • 81.83 (n)
  • 88.76 (a)
SNX14 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX14 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21099 36
tropical clawed frog
(Silurana tropicalis)
Amphibia snx14 36
  • 76.67 (n)
  • 83.59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2489 36
zebrafish
(Danio rerio)
Actinopterygii Dr.25742 36
snx14 36
  • 67.75 (n)
  • 74.16 (a)
snx14 37
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012377 36
  • 44.01 (n)
  • 30.99 (a)
worm
(Caenorhabditis elegans)
Secernentea snx-14 36
  • 41.72 (n)
  • 29.5 (a)
snx-14 37
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToOne
Species with no ortholog for SNX14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX14 Gene

ENSEMBL:
Gene Tree for SNX14 (if available)
TreeFam:
Gene Tree for SNX14 (if available)

Paralogs for SNX14 Gene

Paralogs for SNX14 Gene

Selected SIMAP similar genes for SNX14 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SNX14: view

Variants for SNX14 Gene

Sequence variations from dbSNP and Humsavar for SNX14 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2758840 -- 85,594,907(+) CTAGG(A/C)TCTTA upstream-variant-2KB
rs2842608 -- 85,586,140(+) ctcaa(A/C)aagtc intron-variant
rs2842609 -- 85,587,070(+) agaca(A/G)tgttt intron-variant
rs2842610 -- 85,588,345(+) gaggc(A/G)ggcag intron-variant
rs2842611 -- 85,592,316(+) GTTAC(A/G)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX14 Gene

Variant ID Type Subtype PubMed ID
nsv520112 CNV Loss 19592680
nsv886333 CNV Loss 21882294
nsv463939 CNV Loss 19166990
nsv470839 CNV Loss 18288195
nsv886334 CNV Loss 21882294
nsv516516 CNV Gain+Loss 19592680
esv2676282 CNV Deletion 23128226
nsv5383 CNV Loss 18451855

Relevant External Links for SNX14 Gene

HapMap Linkage Disequilibrium report
SNX14
Human Gene Mutation Database (HGMD)
SNX14

Disorders for SNX14 Gene

genes like me logo Genes that share disorders with SNX14: view

No data available for UniProtKB/Swiss-Prot for SNX14 Gene

Publications for SNX14 Gene

  1. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale R.D. … Gleeson P.A. (Biochem. J. 2001) 2 3 4
  2. The Phox homology (PX) domain, a new player in phosphoinositide signalling. (PMID: 11736640) Xu Y. … Hong W. (Biochem. J. 2001) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PMID: 17370265) Denis N.J. … Figeys D. (Proteomics 2007) 3 4

Products for SNX14 Gene

Sources for SNX14 Gene

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