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Aliases for SNX13 Gene

Aliases for SNX13 Gene

  • Sorting Nexin 13 2 3 5
  • RGS-PX1 3 4
  • Rgs Domain- And Phox Domain-Containing Protein 3
  • RGS Domain- And PHOX Domain-Containing Protein 4
  • KIAA0713 4

External Ids for SNX13 Gene

Previous GeneCards Identifiers for SNX13 Gene

  • GC07M017477
  • GC07M017576
  • GC07M017605

Summaries for SNX13 Gene

Entrez Gene Summary for SNX13 Gene

  • This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX13 Gene

SNX13 (Sorting Nexin 13) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding and phosphatidylinositol-3-phosphate binding. An important paralog of this gene is SNX14.

UniProtKB/Swiss-Prot for SNX13 Gene

  • May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas.

Gene Wiki entry for SNX13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX13 Gene

Genomics for SNX13 Gene

Regulatory Elements for SNX13 Gene

Enhancers for SNX13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNX13 on UCSC Golden Path with GeneCards custom track

Promoters for SNX13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNX13 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX13 Gene

17,790,761 bp from pter
17,940,518 bp from pter
149,758 bases
Minus strand

Genomic View for SNX13 Gene

Genes around SNX13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX13 Gene

Proteins for SNX13 Gene

  • Protein details for SNX13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-13
    Protein Accession:
    Secondary Accessions:
    • B2RCI9
    • O94821
    • Q8WVZ2
    • Q8WXH8

    Protein attributes for SNX13 Gene

    968 amino acids
    Molecular mass:
    112189 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH22060.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA34433.1; Type=Frameshift; Positions=887; Evidence={ECO:0000305};

    Alternative splice isoforms for SNX13 Gene


neXtProt entry for SNX13 Gene

Proteomics data for SNX13 Gene at MOPED

Post-translational modifications for SNX13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX13 Gene

No data available for DME Specific Peptides for SNX13 Gene

Domains & Families for SNX13 Gene

Gene Families for SNX13 Gene

Suggested Antigen Peptide Sequences for SNX13 Gene

Graphical View of Domain Structure for InterPro Entry



  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Belongs to the sorting nexin family.
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Contains 1 PX (phox homology) domain.
  • Contains 1 PXA domain.
  • Contains 1 RGS domain.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX13: view

Function for SNX13 Gene

Molecular function for SNX13 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas.
genes like me logo Genes that share phenotypes with SNX13: view

Animal Models for SNX13 Gene

MGI Knock Outs for SNX13:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNX13 Gene

Localization for SNX13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX13 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for SNX13 Gene COMPARTMENTS Subcellular localization image for SNX13 gene
Compartment Confidence
endosome 5
endoplasmic reticulum 3
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SNX13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 11729322
genes like me logo Genes that share ontologies with SNX13: view

Pathways & Interactions for SNX13 Gene

SuperPathways for SNX13 Gene

No Data Available

Interacting Proteins for SNX13 Gene

Gene Ontology (GO) - Biological Process for SNX13 Gene


No data available for Pathways by source and SIGNOR curated interactions for SNX13 Gene

Drugs & Compounds for SNX13 Gene

(1) Drugs for SNX13 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SNX13: view

Transcripts for SNX13 Gene

Unigene Clusters for SNX13 Gene

Sorting nexin 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX13 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP6: - - -

ExUns: 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29
SP1: - -

Relevant External Links for SNX13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX13 Gene

mRNA expression in normal human tissues for SNX13 Gene

Protein differential expression in normal tissues from HIPED for SNX13 Gene

This gene is overexpressed in Platelet (18.7), Placenta (11.5), Retina (7.7), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNX13 Gene

SOURCE GeneReport for Unigene cluster for SNX13 Gene Hs.487648

genes like me logo Genes that share expression patterns with SNX13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SNX13 Gene

Orthologs for SNX13 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SNX13 35
  • 93.99 (n)
  • 96.21 (a)
SNX13 36
  • 84 (a)
(Canis familiaris)
Mammalia SNX13 35
  • 95.13 (n)
  • 97.69 (a)
SNX13 36
  • 97 (a)
(Mus musculus)
Mammalia Snx13 35
  • 93.07 (n)
  • 97.18 (a)
Snx13 16
Snx13 36
  • 97 (a)
(Pan troglodytes)
Mammalia SNX13 35
  • 99.69 (n)
  • 99.69 (a)
SNX13 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Snx13 35
  • 90.77 (n)
  • 94.51 (a)
(Monodelphis domestica)
Mammalia SNX13 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia SNX13 36
  • 96 (a)
(Gallus gallus)
Aves SNX13 35
  • 84.81 (n)
  • 91.95 (a)
SNX13 36
  • 91 (a)
(Anolis carolinensis)
Reptilia SNX13 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx13 35
  • 79.77 (n)
  • 85.64 (a)
Str.19364 35
(Danio rerio)
Actinopterygii snx13 35
  • 70.17 (n)
  • 79.83 (a)
snx13 36
  • 79 (a)
(Caenorhabditis elegans)
Secernentea Y116A8C.26 37
  • 33 (a)
CELE_Y116A8C.26 35
  • 47.29 (n)
  • 35.8 (a)
snx-13 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
CSA.737 36
  • 42 (a)
Species with no ortholog for SNX13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX13 Gene

Gene Tree for SNX13 (if available)
Gene Tree for SNX13 (if available)

Paralogs for SNX13 Gene

Paralogs for SNX13 Gene

(1) SIMAP similar genes for SNX13 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SNX13: view

Variants for SNX13 Gene

Sequence variations from dbSNP and Humsavar for SNX13 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs35113148 - 17,834,810(+) GATTC(A/G)AAGTA reference, missense
rs949451 -- 17,818,931(-) AGGTA(C/T)AGATA intron-variant
rs1051603 -- 17,822,402(-) ACTCA(C/G)TATTA intron-variant
rs1055751 -- 17,791,755(-) TTTAA(A/C)CATAA utr-variant-3-prime
rs6953831 -- 17,811,585(+) attta(C/T)agatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX13 Gene

Variant ID Type Subtype PubMed ID
nsv887804 CNV Gain 21882294
esv2734066 CNV Deletion 23290073
esv2734067 CNV Deletion 23290073
esv23642 CNV Loss 19812545
nsv830913 CNV Gain+Loss 17160897
esv996210 CNV Gain 20482838
nsv887808 CNV Gain 21882294
esv2463128 CNV Deletion 19546169
esv2734068 CNV Deletion 23290073
esv2734069 CNV Deletion 23290073
esv1984816 CNV Deletion 18987734
esv2734070 CNV Deletion 23290073
esv993770 CNV Deletion 20482838
nsv365749 CNV Loss 16902084

Variation tolerance for SNX13 Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SNX13 Gene

Disorders for SNX13 Gene

Relevant External Links for SNX13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SNX13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX13 Gene

Publications for SNX13 Gene

  1. RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. (PMID: 11729322) Zheng B. … Farquhar M.G. (Science 2001) 2 3 4 23 67
  2. Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region. (PMID: 12438708) Kosan C. … Kunz J. (Cytogenet. Genome Res. 2002) 3 23
  3. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale R.D. … Gleeson P.A. (Biochem. J. 2001) 2 3
  4. Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling. (PMID: 25148684) Mas C. … Collins B.M. (J. Biol. Chem. 2014) 3
  5. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3

Products for SNX13 Gene

Sources for SNX13 Gene