Aliases for SNX13 Gene
External Ids for SNX13 Gene
Previous GeneCards Identifiers for SNX13 Gene
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]
GeneCards Summary for SNX13 Gene
SNX13 (Sorting Nexin 13) is a Protein Coding gene. Diseases associated with SNX13 include acrocephalosyndactylia. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX14.
UniProtKB/Swiss-Prot for SNX13 Gene
May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas.