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Aliases for SNX12 Gene

Aliases for SNX12 Gene

  • Sorting Nexin 12 2 3

External Ids for SNX12 Gene

Previous GeneCards Identifiers for SNX12 Gene

  • GC0XM066458
  • GC0XM067758
  • GC0XM068511
  • GC0XM069147
  • GC0XM070063
  • GC0XM070192
  • GC0XM070197
  • GC0XM070276
  • GC0XM064099

Summaries for SNX12 Gene

Entrez Gene Summary for SNX12 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for SNX12 Gene

SNX12 (Sorting Nexin 12) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX3.

UniProtKB/Swiss-Prot for SNX12 Gene

  • May be involved in several stages of intracellular trafficking.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX12 Gene

Genomics for SNX12 Gene

Regulatory Elements for SNX12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNX12 Gene

70,987,306 bp from pter
71,073,426 bp from pter
86,121 bases
Minus strand

Genomic View for SNX12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX12 Gene

Proteins for SNX12 Gene

  • Protein details for SNX12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-12
    Protein Accession:
    Secondary Accessions:
    • F8W8K5
    • Q8WUG9

    Protein attributes for SNX12 Gene

    172 amino acids
    Molecular mass:
    19730 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SNX12 Gene

    Alternative splice isoforms for SNX12 Gene


neXtProt entry for SNX12 Gene

Proteomics data for SNX12 Gene at MOPED

Post-translational modifications for SNX12 Gene

  • Ubiquitination at Lys62
  • Modification sites at PhosphoSitePlus

Other Protein References for SNX12 Gene

Antibody Products

No data available for DME Specific Peptides for SNX12 Gene

Domains for SNX12 Gene

Gene Families for SNX12 Gene

  • SNX :Sorting nexins

Protein Domains for SNX12 Gene


Suggested Antigen Peptide Sequences for SNX12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UMY4
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Contains 1 PX (phox homology) domain.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX12: view

Function for SNX12 Gene

Molecular function for SNX12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking.

Gene Ontology (GO) - Molecular Function for SNX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0019899 enzyme binding IPI 22709416
GO:0035091 phosphatidylinositol binding IDA 22719997
genes like me logo Genes that share ontologies with SNX12: view

Phenotypes for SNX12 Gene

MGI mutant phenotypes for SNX12:
inferred from 1 alleles
GenomeRNAi human phenotypes for SNX12:
genes like me logo Genes that share phenotypes with SNX12: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNX12 Gene

Localization for SNX12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX12 Gene

Membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for SNX12 Gene COMPARTMENTS Subcellular localization image for SNX12 gene
Compartment Confidence
cytosol 3
endosome 2
nucleus 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SNX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0005769 early endosome IDA 22709416
GO:0016020 membrane --
GO:0019898 extrinsic component of membrane IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SNX12: view

Pathways for SNX12 Gene

SuperPathways for SNX12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport --
GO:0006897 endocytosis IBA --
GO:0010629 negative regulation of gene expression IMP 22709416
GO:0010955 negative regulation of protein processing IDA 22709416
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SNX12: view

No data available for Pathways by source for SNX12 Gene

Transcripts for SNX12 Gene

Unigene Clusters for SNX12 Gene

Sorting nexin 12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX12 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - - -

Relevant External Links for SNX12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX12 Gene

mRNA expression in normal human tissues for SNX12 Gene

Protein differential expression in normal tissues for SNX12 Gene

This gene is overexpressed in Uterus (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX12 Gene

SOURCE GeneReport for Unigene cluster for SNX12 Gene Hs.260750

genes like me logo Genes that share expressions with SNX12: view

Expression partners for SNX12 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX12 Gene

Orthologs for SNX12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SNX12 35
  • 95.27 (n)
  • 100 (a)
SNX12 36
  • 100 (a)
(Canis familiaris)
Mammalia SNX12 35
  • 95.27 (n)
  • 100 (a)
SNX12 36
  • 51 (a)
(Mus musculus)
Mammalia Snx12 35
  • 93.96 (n)
  • 100 (a)
Snx12 16
Snx12 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Snx12 35
  • 93.54 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia SNX12 36
  • 98 (a)
(Pan troglodytes)
Mammalia SNX12 36
  • 100 (a)
(Gallus gallus)
Aves SNX12 35
  • 84.16 (n)
  • 94.44 (a)
SNX12 36
  • 95 (a)
(Anolis carolinensis)
Reptilia SNX12 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx12 35
  • 80.25 (n)
  • 94.44 (a)
(Danio rerio)
Actinopterygii -- 35
snx12 35
  • 75.1 (n)
  • 91.36 (a)
snx12 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12241 35
fruit fly
(Drosophila melanogaster)
Insecta CG6359 37
  • 77 (a)
Snx3 35
  • 71.01 (n)
  • 77.64 (a)
Snx3 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003437 35
  • 68.75 (n)
  • 78.12 (a)
(Caenorhabditis elegans)
Secernentea W06D4.5 37
  • 71 (a)
snx-3 35
  • 64.56 (n)
  • 69.62 (a)
snx-3 36
  • 70 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX3 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
Species with no ortholog for SNX12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX12 Gene

Gene Tree for SNX12 (if available)
Gene Tree for SNX12 (if available)

Paralogs for SNX12 Gene

Paralogs for SNX12 Gene

Selected SIMAP similar genes for SNX12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNX12: view

Variants for SNX12 Gene

Sequence variations from dbSNP and Humsavar for SNX12 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6780 -- 71,059,642(+) TTTCC(A/C)CAGTG utr-variant-3-prime, intron-variant
rs11134 -- 71,059,319(+) TGCTG(A/G)ATAAA utr-variant-3-prime, intron-variant
rs3123568 -- 71,005,077(+) TGTAC(C/G)TATCC intron-variant
rs3123569 -- 71,005,089(+) ATCCC(C/T)ATCCC intron-variant
rs3123570 -- 71,020,639(+) TTGGT(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX12 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv33082 CNV Loss 17666407
nsv6952 CNV Insertion 18451855

Relevant External Links for SNX12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX12 Gene

Disorders for SNX12 Gene

No disorders were found for SNX12 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SNX12 Gene

Publications for SNX12 Gene

  1. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale R.D. … Gleeson P.A. (Biochem. J. 2001) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3

Products for SNX12 Gene

Sources for SNX12 Gene

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