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Aliases for SNX12 Gene

Aliases for SNX12 Gene

  • Sorting Nexin 12 2 3 5

External Ids for SNX12 Gene

Previous GeneCards Identifiers for SNX12 Gene

  • GC0XM066458
  • GC0XM067758
  • GC0XM068511
  • GC0XM069147
  • GC0XM070063
  • GC0XM070192
  • GC0XM070197
  • GC0XM070276
  • GC0XM064099
  • GC0XM070987

Summaries for SNX12 Gene

Entrez Gene Summary for SNX12 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for SNX12 Gene

SNX12 (Sorting Nexin 12) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include enzyme binding and phosphatidylinositol binding. An important paralog of this gene is SNX3.

UniProtKB/Swiss-Prot for SNX12 Gene

  • May be involved in several stages of intracellular trafficking.

Additional gene information for SNX12 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX12 Gene

Genomics for SNX12 Gene

Regulatory Elements for SNX12 Gene

Enhancers for SNX12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH071181 2 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -109.4 -109446 3 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 TAF1 NONO OGT MED12 LOC100420758 ENSG00000229601 ARR3 P2RY4 RTL5 RPS23P8
GH0XH071095 1.5 Ensembl ENCODE dbSUPER 11.8 -24.2 -24177 4 ZNF2 ETS1 TCF12 GLIS2 GATA2 ZNF143 SP3 REST ZNF610 SMARCA4 MED12 CXorf65 SNX12 IL2RG FOXO4
GH0XH071100 1.5 Ensembl ENCODE dbSUPER 11.7 -34.1 -34110 13 HDGF PKNOX1 ATF1 ARNT SIN3A TCF12 ZNF121 ZNF207 FOS ATF7 MED12 CXorf65 SNX12 IL2RG
GH0XH071250 1 ENCODE 11.3 -180.4 -180361 6 HDGF PKNOX1 ARNT SIN3A FEZF1 GLI4 ZNF2 BRCA1 YY1 ZNF766 TAF1 LOC100420758 MED12 NONO OGT ERCC6L ARR3 ENSG00000229601 SNX12 P2RY4
GH0XH071066 1.1 ENCODE 5.5 +5.4 5419 2 PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 ZNF766 ZNF143 ZNF207 FOS MED12 ITGB1BP2 TAF1 IL2RG SNX12 GC0XM071059
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNX12 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX12 Gene

Chromosome:
X
Start:
71,056,332 bp from pter
End:
71,073,426 bp from pter
Size:
17,095 bases
Orientation:
Minus strand

Genomic View for SNX12 Gene

Genes around SNX12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX12 Gene

Proteins for SNX12 Gene

  • Protein details for SNX12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMY4-SNX12_HUMAN
    Recommended name:
    Sorting nexin-12
    Protein Accession:
    Q9UMY4
    Secondary Accessions:
    • F8W8K5
    • Q8WUG9

    Protein attributes for SNX12 Gene

    Size:
    172 amino acids
    Molecular mass:
    19730 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SNX12 Gene

    Alternative splice isoforms for SNX12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX12 Gene

Post-translational modifications for SNX12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX12 Gene

No data available for DME Specific Peptides for SNX12 Gene

Domains & Families for SNX12 Gene

Gene Families for SNX12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNX12 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX12 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UMY4

UniProtKB/Swiss-Prot:

SNX12_HUMAN :
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX12: view

Function for SNX12 Gene

Molecular function for SNX12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking.

Gene Ontology (GO) - Molecular Function for SNX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008289 lipid binding IEA --
GO:0019899 enzyme binding IPI 22709416
GO:0035091 phosphatidylinositol binding IEA,IDA 22719997
genes like me logo Genes that share ontologies with SNX12: view
genes like me logo Genes that share phenotypes with SNX12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SNX12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX12 Gene

Localization for SNX12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX12 Gene

Membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX12 gene
Compartment Confidence
extracellular 5
endosome 5
cytosol 3
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SNX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 22709416
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SNX12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SNX12 Gene

Pathways & Interactions for SNX12 Gene

SuperPathways for SNX12 Gene

SuperPathway Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with SNX12: view

Pathways by source for SNX12 Gene

1 KEGG pathway for SNX12 Gene

Gene Ontology (GO) - Biological Process for SNX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0010629 negative regulation of gene expression IMP 22709416
GO:0010955 negative regulation of protein processing IDA 22709416
GO:0015031 protein transport IEA --
GO:0016050 vesicle organization IBA --
genes like me logo Genes that share ontologies with SNX12: view

No data available for SIGNOR curated interactions for SNX12 Gene

Drugs & Compounds for SNX12 Gene

No Compound Related Data Available

Transcripts for SNX12 Gene

Unigene Clusters for SNX12 Gene

Sorting nexin 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SNX12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SNX12 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - - -

Relevant External Links for SNX12 Gene

GeneLoc Exon Structure for
SNX12
ECgene alternative splicing isoforms for
SNX12

Expression for SNX12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX12 Gene

Protein differential expression in normal tissues from HIPED for SNX12 Gene

This gene is overexpressed in Uterus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX12 Gene



Protein tissue co-expression partners for SNX12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNX12 Gene:

SNX12

SOURCE GeneReport for Unigene cluster for SNX12 Gene:

Hs.260750

Evidence on tissue expression from TISSUES for SNX12 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SNX12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX12 Gene

Orthologs for SNX12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX12 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNX12 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNX12 33 34
  • 95.27 (n)
dog
(Canis familiaris)
Mammalia SNX12 33 34
  • 95.27 (n)
mouse
(Mus musculus)
Mammalia Snx12 16 34 33
  • 93.96 (n)
rat
(Rattus norvegicus)
Mammalia Snx12 33
  • 93.54 (n)
chicken
(Gallus gallus)
Aves SNX12 33 34
  • 84.16 (n)
lizard
(Anolis carolinensis)
Reptilia SNX12 34
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx12 33
  • 80.25 (n)
zebrafish
(Danio rerio)
Actinopterygii snx12 33 34
  • 75.1 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12241 33
fruit fly
(Drosophila melanogaster)
Insecta CG6359 35
  • 77 (a)
Snx3 33 34
  • 71.01 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003437 33
  • 68.75 (n)
worm
(Caenorhabditis elegans)
Secernentea W06D4.5 35
  • 71 (a)
snx-3 33 34
  • 64.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX3 34
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 69 (a)
OneToMany
Species where no ortholog for SNX12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX12 Gene

ENSEMBL:
Gene Tree for SNX12 (if available)
TreeFam:
Gene Tree for SNX12 (if available)

Paralogs for SNX12 Gene

Paralogs for SNX12 Gene

(5) SIMAP similar genes for SNX12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNX12: view

Variants for SNX12 Gene

Sequence variations from dbSNP and Humsavar for SNX12 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000118751 -- 71,059,807(+) AGGAT(A/G)GTTGC utr-variant-3-prime
rs1000469655 -- 71,059,136(+) AAATG(C/T)AAAAC downstream-variant-500B
rs1001046916 -- 71,072,565(+) AGAGA(A/C)TCTTT intron-variant
rs1001248649 -- 71,068,428(+) GCGCG(-/CACGCGCGCC)CACGC intron-variant, utr-variant-5-prime
rs1001307739 -- 71,059,896(+) AAAAT(C/G)CTGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SNX12 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv33082 CNV loss 17666407
nsv476904 CNV novel sequence insertion 20440878
nsv6952 CNV insertion 18451855

Variation tolerance for SNX12 Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX12 Gene

Disorders for SNX12 Gene

Relevant External Links for SNX12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX12

No disorders were found for SNX12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX12 Gene

Publications for SNX12 Gene

  1. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale RD … Gleeson PA (The Biochemical journal 2001) 3 4 22 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60

Products for SNX12 Gene

Sources for SNX12 Gene

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