SNX12 Gene
protein-coding GIFtS: 51
GCID: GC0XM070276
|
|
sorting nexin 12
| |
Aliases
for SNX12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sorting Nexin 121 2 | | Sorting Nexin-122 |
Export aliases for SNX12 gene to outside databasesPrevious GC identifers: GC0XM066458 GC0XM067758 GC0XM068511 GC0XM069147 GC0XM070063 GC0XM070192 GC0XM070197 GC0XM064099 |
Summaries
for SNX12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNX12:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiledcoil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth.Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jan 2012)
UniProtKB/Swiss-Prot: SNX12_HUMAN, Q9UMY4Function: May be involved in several stages of intracellular trafficking (By similarity)
|
Genomic Views
for SNX12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNX12 gene promoter:
TBP C/EBPbeta FOXF2 p53 COMP1 TFIID HFH-1 c-Myb En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1SNX12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM070276: view genomic region
(about GC identifiers)
Start:
|
70,279,094 bp from pter |
End:
|
70,288,273 bp from pter |
Size:
|
9,180 bases |
Orientation:
|
minus strand |
|
Proteins
for SNX12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNX12_HUMAN, Q9UMY4 (See
protein sequence)Recommended Name: Sorting nexin-12 Size: 172 amino acids; 19730 Da
Subcellular location: Membrane; Peripheral membrane protein; Cytoplasmic side (Potential)
1 PDB 3D structure from  and Proteopedia  for SNX12:2CSK (3D)
Secondary accessions: Q8WUG9Alternative splicing: 2 isoforms: Q9UMY4-1 Q9UMY4-2 Explore the universe of human proteins at neXtProt for SNX12: NX_Q9UMY4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UMY4
SNX12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001243114.1 NP_001243115.1 NP_001243116.1 NP_001243117.1 NP_037478.2
ENSEMBL proteins: ENSP00000363392 ENSP00000276105
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- |
SNX12 for ontologies About GeneDecksing
SNX12 Antibody Products:
Assay Products for SNX12: |
Protein
Domains /
Families
for SNX12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UMY4ProtoNet protein and cluster: Q9UMY4 1 Blocks protein family: IPB001683 Phox-like
UniProtKB/Swiss-Prot: SNX12_HUMAN, Q9UMY4Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate (By similarity)Similarity: Belongs to the sorting nexin familySimilarity: Contains 1 PX (phox homology) domain |
Function
for SNX12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNX12_HUMAN, Q9UMY4Function: May be involved in several stages of intracellular trafficking (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX12 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SNX12 (NM_013346) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX12 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SNX12 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SNX12:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Snx12):
SNX12 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SNX12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/537 Interacting proteins for SNX12 (Q9UMY41, 2, 3 ENSP000003633924) via UniProtKB, MINT, STRING, and/or I2D (see all 537)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007154 | cell communication |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- |
SNX12 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNX12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNX12
Search CenterWatch for drugs/clinical trials and news about SNX12
|
Transcripts
for SNX12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNX12 gene (5 alternative transcripts): NM_001256185.1 NM_001256186.1 NM_001256187.1 NM_001256188.1 NM_013346.3 Unigene Cluster for SNX12: Sorting nexin 12 Hs.260750 [show with all ESTs]Unigene Representative Sequence: NM_0012561855 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000483560 ENST00000374274(uc004dyp.1 uc004dyr.1) ENST00000490561
ENST00000465030 ENST00000276105
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX12 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNX12 (NM_013346) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX12 |
Additional cDNA sequence: AF171229.1 AK025781.1 AK312977.1 BC024301.1 BC033809.1 BC044059.1 BC063716.1 BC080535.1 BC103847.2 BC103848.1 BC108323.1 BT007203.1 10 DOTS entries: DT.453894 DT.121323354 DT.100811966 DT.100811972 DT.100842384 DT.100811961 DT.91774879 DT.97818329 DT.91765745 DT.100811969 24/282 AceView cDNA sequences (see all 282): T30489 BU183048 BX346272 AI829483 NM_013346 BF035871 CR624966 AI767402 BM841021 BC024301 BE384982 AI332882 BQ637207 BU682830 BC063716 BC044059 AI192201 AI733888 BI518693 BM470957 AI719178 CR594125 AA027151 BM786515
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SNX12 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SNX12
|
Expression
for SNX12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAGATTGG
About this image
See SNX12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX12
SOURCE GeneReport for Unigene cluster: Hs.260750
SABiosciences Custom PCR Arrays for SNX12
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX12 |
Orthologs
for SNX12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNX12 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for SNX12 (if available)
TreeFam Gene Tree for SNX12 (if available) |
Paralogs
for SNX12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNX12 gene
- SNX102 SNX32 SNX112
5 SIMAP similar genes for SNX12 using alignment to 3 protein entries: SNX12_HUMAN (see all proteins):SNX3 SNX11 SNX10 SNX1 SNX30
SNX12 for paralogs About GeneDecksing
|
Genomic Variants
for SNX12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX12 (70279094 - 70288273 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SNX12
1 CNV: 7797 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX12 |
|
Disorders
/ Diseases
for SNX12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNX12 for disorders About GeneDecksing
OMIM gene information: 300883
OMIM disorders: --
2  diseases for SNX12: About MalaCardscerebritis neuronitis
Export disorders for SNX12 gene to outside databases
|
Publications
for SNX12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX12 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SNX12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)1, 2, 9 Teasdale R.D.... Gleeson P.A. (2001)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Expression of sorting nexin 12 is regulated in develo ping cerebral cortical neurons. (PubMed id 22109349)1 Mizutani R....Tanoue A. (2012)
- SNX12 role in endosome membrane transport. (PubMed id 22719997)1 Pons V....Gruenberg J. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for SNX12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNX12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNX12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNX12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX12 gene:
Search GeneIP for patents involving SNX12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNX12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for SNX12 | | OriGene shRNA RFP for SNX12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX12 | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for SNX12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SNX12 | | OriGene 3'-UTR Clone for SNX12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SNX12 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SNX12 | | OriGene Custom Protein Services for SNX12 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX12 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SNX12 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SNX12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX12 |
|  |  |  | | | | ThermoFisher Antibody for SNX12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX12 |
|
|
|
|
