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Aliases for SNX11 Gene

Aliases for SNX11 Gene

  • Sorting Nexin 11 2 3

External Ids for SNX11 Gene

Previous GeneCards Identifiers for SNX11 Gene

  • GC17P045890
  • GC17P048665
  • GC17P046526
  • GC17P046659
  • GC17P043539
  • GC17P046184
  • GC17P041555

Summaries for SNX11 Gene

Entrez Gene Summary for SNX11 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX11 Gene

SNX11 (Sorting Nexin 11) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol phosphate binding. An important paralog of this gene is SNX3.

UniProtKB/Swiss-Prot for SNX11 Gene

  • Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX11 Gene

Genomics for SNX11 Gene

Regulatory Elements for SNX11 Gene

Genomic Location for SNX11 Gene

48,103,357 bp from pter
48,123,074 bp from pter
19,718 bases
Plus strand

Genomic View for SNX11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX11 Gene

Proteins for SNX11 Gene

  • Protein details for SNX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-11
    Protein Accession:
    Secondary Accessions:
    • B3KRL6
    • B4DPY5
    • D3DTV0
    • Q53YC0
    • Q9H885

    Protein attributes for SNX11 Gene

    270 amino acids
    Molecular mass:
    30433 Da
    Quaternary structure:
    • Monomer.
    • Sequence=AAD27834.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNX11 Gene

    Alternative splice isoforms for SNX11 Gene


neXtProt entry for SNX11 Gene

Proteomics data for SNX11 Gene at MOPED

Post-translational modifications for SNX11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SNX11

No data available for DME Specific Peptides for SNX11 Gene

Domains for SNX11 Gene

Gene Families for SNX11 Gene

  • SNX :Sorting nexins

Protein Domains for SNX11 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9Y5W9
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Contains 1 PX (phox homology) domain.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX11: view

Function for SNX11 Gene

Molecular function for SNX11 Gene

UniProtKB/Swiss-Prot Function:
Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.

Gene Ontology (GO) - Molecular Function for SNX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0035091 phosphatidylinositol binding --
GO:1901981 phosphatidylinositol phosphate binding IDA 23615901
genes like me logo Genes that share ontologies with SNX11: view

Phenotypes for SNX11 Gene

genes like me logo Genes that share phenotypes with SNX11: view

Animal Model Products

miRNA for SNX11 Gene

miRTarBase miRNAs that target SNX11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNX11 Gene

Localization for SNX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX11 Gene

Membrane; Peripheral membrane protein; Cytoplasmic side. Endosome.

Subcellular locations from

Jensen Localization Image for SNX11 Gene COMPARTMENTS Subcellular localization image for SNX11 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SNX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 23615901
GO:0016020 membrane --
GO:0019898 extrinsic component of membrane IBA --
genes like me logo Genes that share ontologies with SNX11: view

Pathways for SNX11 Gene

SuperPathways for SNX11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006897 endocytosis IBA --
GO:0016050 vesicle organization IMP 23615901
genes like me logo Genes that share ontologies with SNX11: view

No data available for Pathways by source for SNX11 Gene

Transcripts for SNX11 Gene

Unigene Clusters for SNX11 Gene

Sorting nexin 11:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNX11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: -
SP10: -
SP11: -

Relevant External Links for SNX11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX11 Gene

mRNA expression in normal human tissues for SNX11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNX11 Gene

This gene is overexpressed in Whole Blood (4.9).

Protein differential expression in normal tissues for SNX11 Gene

This gene is overexpressed in Pancreatic juice (26.9) and Breast (26.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX11 Gene

SOURCE GeneReport for Unigene cluster for SNX11 Gene Hs.15827

genes like me logo Genes that share expressions with SNX11: view

Expression partners for SNX11 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SNX11 Gene

Orthologs for SNX11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SNX11 35
  • 88.64 (n)
  • 90.37 (a)
SNX11 36
  • 90 (a)
(Canis familiaris)
Mammalia SNX11 35
  • 88.4 (n)
  • 90.74 (a)
SNX11 36
  • 89 (a)
(Mus musculus)
Mammalia Snx11 35
  • 82.96 (n)
  • 84.44 (a)
Snx11 16
Snx11 36
  • 84 (a)
(Pan troglodytes)
Mammalia SNX11 35
  • 99.63 (n)
  • 99.26 (a)
SNX11 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Snx11 35
  • 85.06 (n)
  • 87.78 (a)
(Monodelphis domestica)
Mammalia SNX11 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia SNX11 36
  • 68 (a)
(Gallus gallus)
Aves SNX11 35
  • 76.68 (n)
  • 78.69 (a)
-- 36
  • 81 (a)
-- 36
  • 89 (a)
(Anolis carolinensis)
Reptilia SNX11 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx11 35
  • 70.21 (n)
  • 73.75 (a)
Str.15224 35
(Danio rerio)
Actinopterygii Dr.16273 35
snx11 36
  • 26 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1432 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX3 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for SNX11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX11 Gene

Gene Tree for SNX11 (if available)
Gene Tree for SNX11 (if available)

Paralogs for SNX11 Gene

Paralogs for SNX11 Gene

Selected SIMAP similar genes for SNX11 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SNX11: view

Variants for SNX11 Gene

Sequence variations from dbSNP and Humsavar for SNX11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1010228 -- 48,122,986(+) GTATA(A/C)TTTAC downstream-variant-500B
rs1010229 -- 48,123,082(+) CCTGG(C/G)TGGTA downstream-variant-500B
rs1045034 -- 48,122,510(+) CCATT(C/T)TTCAT utr-variant-3-prime
rs1045044 -- 48,122,562(+) GCATT(C/T)TGCAT utr-variant-3-prime
rs2072441 -- 48,107,652(-) GAATA(C/G)CGCGG utr-variant-5-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX11 Gene

Variant ID Type Subtype PubMed ID
nsv469808 CNV Complex 16826518
nsv908576 CNV Gain 21882294
nsv112217 CNV Loss 16902084
esv1007058 CNV Deletion 20482838

Relevant External Links for SNX11 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX11 Gene

Disorders for SNX11 Gene

No disorders were found for SNX11 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SNX11 Gene

Publications for SNX11 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale R.D. … Gleeson P.A. (Biochem. J. 2001) 3 4
  4. Structure of Sorting Nexin 11 (SNX11) reveals a novel extended PX Domain (PXe Domain) critical for the inhibition of Sorting Nexin 10 (SNX10) induced vacuolation. (PMID: 23615901) Xu J. … Liu J. (J. Biol. Chem. 2013) 3 4
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SNX11 Gene

Sources for SNX11 Gene

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