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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNX11 Gene

protein-coding   GIFtS: 45
GCID: GC17P046184

sorting nexin 11
  Search for SNX11
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNX11    

Aliases
for SNX11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sorting Nexin 111 2
Sorting Nexin-112

External Ids:    HGNC: 149751   Entrez Gene: 299162   Ensembl: ENSG000000029197   OMIM: 6149065   UniProtKB: Q9Y5W93   

Export aliases for SNX11 gene to outside databases

Previous GC identifers: GC17P045890 GC17P048665 GC17P046526 GC17P046659 GC17P043539 GC17P041555


Summaries
for SNX11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SNX11:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a
phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled
coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two
transcript variants differing in the 5' UTR, but encoding the same protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SNX11_HUMAN, Q9Y5W9
Function: May be involved in several stages of intracellular trafficking (By similarity)




Genomic Views
for SNX11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNX11 gene promoter:
         CREB   Tal-1   deltaCREB   Pax-4a   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNX11 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNX11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

SNX11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P046184:  view genomic region     (about GC identifiers)

Start:
 46,180,719 bp from pter      End:
 46,200,436 bp from pter
Size:
 19,718 bases      Orientation:
 plus strand

Proteins
for SNX11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SNX11_HUMAN, Q9Y5W9 (See protein sequence)
Recommended Name: Sorting nexin-11  
Size: 270 amino acids; 30433 Da
Subcellular location: Membrane; Peripheral membrane protein; Cytoplasmic side (Potential)
Sequence caution: Sequence=AAD27834.1; Type=Erroneous initiation;
Secondary accessions: B3KRL6 D3DTV0 Q53YC0 Q9H885

Explore the universe of human proteins at neXtProt for SNX11: NX_Q9Y5W9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5W9

    • SNX11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_037455.2  NP_689450.1  

    ENSEMBL proteins: 
     ENSP00000464136   ENSP00000462188   ENSP00000396790   ENSP00000377059   ENSP00000464410  
     ENSP00000352175   ENSP00000463250   ENSP00000463948   ENSP00000463726   ENSP00000463076  
     ENSP00000407369  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SNX11

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--


    SNX11 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SNX11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNX11 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001683 Phox

    Graphical View of Domain Structure for InterPro Entry Q9Y5W9

    ProtoNet protein and cluster: Q9Y5W9

    1 Blocks protein family: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SNX11_HUMAN, Q9Y5W9
    Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate (By similarity)
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain


    Function
    for SNX11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SNX11_HUMAN, Q9Y5W9
    Function: May be involved in several stages of intracellular trafficking (By similarity)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: SNX11 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX11 (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035091phosphatidylinositol binding IEA--


    SNX11 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SNX11:
     Decreased viability of wild-ty 


    Pathways & Interactions
    for SNX11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNX11

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007154cell communication IEA--
    GO:0015031protein transport IEA--


    SNX11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNX11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNX11
    Search CenterWatch for drugs/clinical trials and news about SNX11 

    Transcripts
    for SNX11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNX11 gene (2 alternative transcripts): 
    NM_013323.2  NM_152244.1  

    Unigene Cluster for SNX11:

    Sorting nexin 11
    Hs.15827  [show with all ESTs]
    Unigene Representative Sequence: AK023932
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000581298 ENST00000578861 ENST00000580219 ENST00000452859 ENST00000393405(uc010wlg.1 uc002inf.1 uc002ing.1 uc010wlh.1 uc010wli.1 uc010wlj.1 uc002inh.1)
    ENST00000580875 ENST00000581705 ENST00000359238 ENST00000583320 ENST00000582104
    ENST00000584335 ENST00000582481 ENST00000577310 ENST00000439357

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX11
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    hsa-miR-3173-3p hsa-miR-4289 hsa-miR-146a* hsa-miR-1233 hsa-miR-3926 hsa-miR-2355-5p hsa-miR-214 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SNX11 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF121861.1 AK023932.1 AK091852.1 AK296095.1 AK296569.1 AK298551.1 AK316374.1 BC000768.2 
    BC103721.1 BT006723.1 

    9 DOTS entries:

    DT.91746218  DT.114427  DT.100790793  DT.97770690  DT.95247427  DT.91746215  DT.91746214  DT.40260059 
    DT.92056707 

    24/177 AceView cDNA sequences (see all 177):

    BI760338 BU739766 AI634284 BX956358 BE277406 AI202171 BQ435064 CA309129 
    BM820627 BQ022488 CR593364 AV647064 AI734245 H79214 H67933 AU156808 
    NM_152244 NM_013323 AV707986 AI369845 AL598906 BI907115 AA552016 BG231638 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SNX11 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f
    SP1:                                                              -     -     -           -           -                                                         
    SP2:                                                  -           -     -     -                       -                                                         
    SP3:                          -     -     -     -     -                 -     -           -           -                                                         
    SP4:                                                  -           -     -     -           -           -                                                         
    SP5:                                                  -                 -     -           -           -                                                         


    ECgene alternative splicing isoforms for SNX11

    Expression
    for SNX11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNX11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCATTTAGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SNX11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SNX11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNX11

    SOURCE GeneReport for Unigene cluster: Hs.15827
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    In Situ
    Assay Products:     
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    Orthologs
    for SNX11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SNX11 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SNX111 sorting nexin 11 76.84(n)
    80.23(a)    		   429353  XM_003642796.1  XP_003642844.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SNX116
    		 --
    		 85(a)
    		 1 ↔ 1
    		 6(75012014-75022592)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.152242 Transcribed sequence with moderate similarity to protein spQ9Y5W9 (H.sapiens) SNXB_HUMAN Sorting nexin 11 less 73.38(n)    AL869614.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.162732 Transcribed sequence with moderate similarity to protein spQ9Y5W9 (H.sapiens) SNXB_HUMAN Sorting nexin 11 less 77.92(n)    BI473731.1 


    ENSEMBL Gene Tree for SNX11 (if available)
    TreeFam Gene Tree for SNX11 (if available) 

    Paralogs
    for SNX11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNX11 gene
    SNX102  SNX32  SNX122  
    3 SIMAP similar genes for SNX11 using alignment to 9 protein entries:     SNX11_HUMAN (see all proteins):
    SNX10    SNX3    SNX12

    SNX11 for paralogs           About GeneDecksing



    Genomic Variants
    for SNX11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/291 NCBI SNPs in SNX11 are shown (see all 291)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1830094691,2
    		--46182945(+) GGTGGC/TACACA 1 -- us2k10--------
    rs1507766431,2
    		--46183048(+) GGCACA/GGTGGC 2 -- us2k10--------
    rs99105161,2
    		C,F,--46183160(+) TAAAAG/ATACAA 2 -- us2k15Minor allele frequency- A:0.44NA WA CSA 9
    rs344494971,2
    		F,--46183189(+) GGCGCA/GTGCCT 2 -- us2k14Minor allele frequency- G:0.30NA 10
    rs562581991,2
    		C,F,--46183246(+) AGATCA/GGTGAT 2 -- us2k14Minor allele frequency- G:0.20WA NA 242
    rs2014656291,2
    		--46183269(+) TGTGA-/TTTTTT 2 -- us2k10--------
    rs1471546881,2
    		--46183285(+) ATTGAA/CTAAAT 2 -- us2k10--------
    rs99107891,2
    		C,H,--46183289(+) aataaA/Ctgcat 2 -- us2k14Minor allele frequency- C:0.00NS EA 386
    rs1866037261,2
    		--46183385(+) CCATCG/TCCAAG 2 -- us2k10--------
    rs1442449531,2
    		--46183432(+) CAGTCG/TCGGCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNX11 (46180719 - 46200436 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SNX11
         1 CNV: 5865

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX11
    DNA2.0 Custom Variant and Variant Library Synthesis for SNX11

    Disorders / Diseases
    for SNX11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNX11 for disorders           About MalaCards

    SNX11 for disorders           About GeneDecksing

    OMIM gene information: 614906    OMIM disorders: --


    Export disorders for SNX11 gene to outside databases

    Publications
    for SNX11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNX11 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SNX11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)1, 2 Teasdale R.D.... Gleeson P.A. (2001)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Sorting out the cellular functions of sorting nexins. (PubMed id 12461558)1 Worby C.A. and Dixon J.E. (2002)

    External Searches for SNX11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SNX11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29916 HGNC: 14975 AceView: SNX11 Ensembl:ENSG00000002919 euGenes: HUgn29916
    ECgene: SNX11 H-InvDB: SNX11

    Other Databases showing SNX11 gene

    (According to HUGE)
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    Specialized Databases showing SNX11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for SNX11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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