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Aliases for SNX11 Gene

Aliases for SNX11 Gene

  • Sorting Nexin 11 2 3 5

External Ids for SNX11 Gene

Previous GeneCards Identifiers for SNX11 Gene

  • GC17P045890
  • GC17P048665
  • GC17P046526
  • GC17P046659
  • GC17P043539
  • GC17P046184
  • GC17P041555

Summaries for SNX11 Gene

Entrez Gene Summary for SNX11 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX11 Gene

SNX11 (Sorting Nexin 11) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding and phosphatidylinositol phosphate binding. An important paralog of this gene is SNX10.

UniProtKB/Swiss-Prot for SNX11 Gene

  • Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX11 Gene

Genomics for SNX11 Gene

Regulatory Elements for SNX11 Gene

Enhancers for SNX11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G048044 1.7 VISTA ENCODE dbSUPER 39.3 -52.3 -52251 13.0 CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 SNX11 MRPL45P2 SCRN2 COPZ2 CDK5RAP3 ENSG00000253347 ENSG00000264701 KPNB1 CBX1 RNU6-1201P
GH17G048238 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +138.8 138806 7.2 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF766 FOS JUNB TBX21 ZNF592 SNX11 COPZ2 CDK5RAP3 ITGB3 RNU6-1152P SKAP1 MIR1203 EGID-105371807 ENSG00000266601 CBX1
GH17G048099 1.4 Ensembl ENCODE 29.6 -1.8 -1834 4.2 HNRNPUL1 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 SNX11 ENSG00000230532 MRPL45P2 CDK5RAP3 SP6 ENSG00000264701 ENSG00000266601 SUMO2P17 CBX1
GH17G048023 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -78.0 -78035 4.6 CREB3L1 ZFP64 DMAP1 FEZF1 ZNF143 ZNF548 SP3 NFYC TBX21 MEF2D SNX11 ENSG00000266601 CDK5RAP3 COPZ2 ITGB3 ENSG00000253347 MRPL45P2 SKAP1 PRR15L NFE2L1
GH17G048058 0.9 dbSUPER 39.3 -42.9 -42921 4.5 HDGF PKNOX1 GLIS2 ZNF366 FOS RELB IKZF2 ZNF263 ZNF362 HCFC1 SNX11 SKAP1 COPZ2 CDK5RAP3 MIR152 RNU6-1201P CBX1 PRR15L MIR1203 HOXB-AS4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNX11 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX11 Gene

Chromosome:
17
Start:
48,103,357 bp from pter
End:
48,123,074 bp from pter
Size:
19,718 bases
Orientation:
Plus strand

Genomic View for SNX11 Gene

Genes around SNX11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX11 Gene

Proteins for SNX11 Gene

  • Protein details for SNX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5W9-SNX11_HUMAN
    Recommended name:
    Sorting nexin-11
    Protein Accession:
    Q9Y5W9
    Secondary Accessions:
    • B3KRL6
    • B4DPY5
    • D3DTV0
    • Q53YC0
    • Q9H885

    Protein attributes for SNX11 Gene

    Size:
    270 amino acids
    Molecular mass:
    30433 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAD27834.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNX11 Gene

    Alternative splice isoforms for SNX11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX11 Gene

Post-translational modifications for SNX11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX11 Gene

Domains & Families for SNX11 Gene

Gene Families for SNX11 Gene

Protein Domains for SNX11 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y5W9

UniProtKB/Swiss-Prot:

SNX11_HUMAN :
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX11: view

Function for SNX11 Gene

Molecular function for SNX11 Gene

UniProtKB/Swiss-Prot Function:
Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.

Gene Ontology (GO) - Molecular Function for SNX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
GO:0035091 phosphatidylinositol binding IEA --
GO:1901981 phosphatidylinositol phosphate binding IDA 23615901
genes like me logo Genes that share ontologies with SNX11: view
genes like me logo Genes that share phenotypes with SNX11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX11 Gene

Localization for SNX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX11 Gene

Membrane; Peripheral membrane protein; Cytoplasmic side. Endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX11 gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SNX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005768 endosome IEA,IDA 23615901
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IBA --
genes like me logo Genes that share ontologies with SNX11: view

Pathways & Interactions for SNX11 Gene

SuperPathways for SNX11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006897 endocytosis IBA --
GO:0015031 protein transport IEA --
GO:0016050 vesicle organization IMP 23615901
genes like me logo Genes that share ontologies with SNX11: view

No data available for Pathways by source and SIGNOR curated interactions for SNX11 Gene

Drugs & Compounds for SNX11 Gene

No Compound Related Data Available

Transcripts for SNX11 Gene

Unigene Clusters for SNX11 Gene

Sorting nexin 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: -
SP10: -
SP11: -

Relevant External Links for SNX11 Gene

GeneLoc Exon Structure for
SNX11
ECgene alternative splicing isoforms for
SNX11

Expression for SNX11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNX11 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for SNX11 Gene

This gene is overexpressed in Pancreatic juice (26.9) and Breast (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX11 Gene



Protein tissue co-expression partners for SNX11 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNX11 Gene:

SNX11

SOURCE GeneReport for Unigene cluster for SNX11 Gene:

Hs.15827

Evidence on tissue expression from TISSUES for SNX11 Gene

  • Kidney(4.2)
  • Lung(4.2)
  • Thyroid gland(4.2)
  • Skin(4.1)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with SNX11: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX11 Gene

Orthologs for SNX11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX11 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia SNX11 34 35
  • 88.64 (n)
dog
(Canis familiaris)
Mammalia SNX11 34 35
  • 88.4 (n)
rat
(Rattus norvegicus)
Mammalia Snx11 34
  • 85.06 (n)
mouse
(Mus musculus)
Mammalia Snx11 34 16 35
  • 82.96 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX11 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX11 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 89 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
SNX11 34
  • 76.68 (n)
lizard
(Anolis carolinensis)
Reptilia SNX11 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx11 34
  • 70.21 (n)
Str.15224 34
zebrafish
(Danio rerio)
Actinopterygii snx11 35
  • 26 (a)
OneToOne
Dr.16273 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1432 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX3 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for SNX11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX11 Gene

ENSEMBL:
Gene Tree for SNX11 (if available)
TreeFam:
Gene Tree for SNX11 (if available)

Paralogs for SNX11 Gene

Paralogs for SNX11 Gene

(3) SIMAP similar genes for SNX11 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SNX11: view

Variants for SNX11 Gene

Sequence variations from dbSNP and Humsavar for SNX11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000191654 -- 48,106,707(+) TCGAA(C/T)TCCTG upstream-variant-2KB
rs1000226766 -- 48,108,244(+) CTTTG(-/TTAC)TTACC intron-variant
rs1000324571 -- 48,115,917(+) TTTTT(-/G)TTTTG intron-variant
rs1000404740 -- 48,112,478(+) AGTGA(A/G)TGAAA intron-variant
rs1000531645 -- 48,107,284(+) GGAGT(C/T)CCCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNX11 Gene

Variant ID Type Subtype PubMed ID
esv1007058 CNV deletion 20482838
esv3582798 CNV loss 25503493
nsv112217 CNV deletion 16902084
nsv469808 CNV loss 16826518

Variation tolerance for SNX11 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNX11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX11 Gene

Disorders for SNX11 Gene

Relevant External Links for SNX11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX11

No disorders were found for SNX11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX11 Gene

Publications for SNX11 Gene

  1. Structure of Sorting Nexin 11 (SNX11) reveals a novel extended PX Domain (PXe Domain) critical for the inhibition of Sorting Nexin 10 (SNX10) induced vacuolation. (PMID: 23615901) Xu J. … Liu J. (J. Biol. Chem. 2013) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale R.D. … Gleeson P.A. (Biochem. J. 2001) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SNX11 Gene

Sources for SNX11 Gene

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