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SNX10 Gene

protein-coding   GIFtS: 48
GCID: GC07P026331

Sorting Nexin 10

  See SNX10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sorting Nexin 101 2
OPTB82 5
Sorting Nexin-102

External Ids:    HGNC: 149741   Entrez Gene: 298872   Ensembl: ENSG000000863007   OMIM: 6147805   UniProtKB: Q9Y5X03   

Export aliases for SNX10 gene to outside databases

Previous GC identifers: GC07P025975 GC07P026073 GC07P026104 GC07P026298 GC07P026213


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNX10 Gene:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which
is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not
contain a coiled coil region, like some family members. This gene may play a role in regulating endosome
homeostasis. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2010)

GeneCards Summary for SNX10 Gene:
SNX10 (sorting nexin 10) is a protein-coding gene. Diseases associated with SNX10 include osteopetrosis, autosomal recessive 8, and osteopetrosis autosomal recessive 1. GO annotations related to this gene include ATPase binding and 1-phosphatidylinositol binding. An important paralog of this gene is SNX3.

UniProtKB/Swiss-Prot: SNX10_HUMAN, Q9Y5X0
Function: Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in
endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins
to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A.
Involved in osteoclast differentiation and therefore bone resorption




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SNX10 gene promoter:
         TBP   AP-1   POU3F2   C/EBPalpha   GATA-1   GATA-2   CHOP-10   SRY   NF-kappaB2   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SNX10 promoter sequence
   Search Chromatin IP Primers for SNX10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNX10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

SNX10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX10 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P026331:  view genomic region     (about GC identifiers)

Start:
26,331,515 bp from pter      End:
26,413,949 bp from pter
Size:
82,435 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 26,382,693-26,465,116     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SNX10_HUMAN, Q9Y5X0 (See protein sequence)
Recommended Name: Sorting nexin-10  
Size: 201 amino acids; 23598 Da
Subunit: Interacts with ATP6V1D; may play a role in ciliogenesis
Secondary accessions: E9PFH5 Q8IYT5
Alternative splicing: 2 isoforms:  Q9Y5X0-1   Q9Y5X0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SNX10: NX_Q9Y5X0

Explore proteomics data for SNX10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys79, Lys148
  • Modification sites at PhosphoSitePlus

  • See SNX10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001186764.1  NP_001186766.1  NP_001186767.1  NP_037454.2  

    ENSEMBL proteins: 
     ENSP00000408164   ENSP00000343709   ENSP00000393690   ENSP00000379661   ENSP00000387274  
     ENSP00000386540   ENSP00000395474  

    SNX10 Human Recombinant Protein Products:

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    Novus Biologicals SNX10 Protein
    Novus Biologicals SNX10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNX10

     
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    antibodies-online proteins for SNX10 (4 products) 

     
    antibodies-online peptides for SNX10

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    antibodies-online antibodies for SNX10 (19 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SNX: Sorting nexins

    1 InterPro protein domain:
     IPR001683 Phox

    Graphical View of Domain Structure for InterPro Entry Q9Y5X0

    ProtoNet protein and cluster: Q9Y5X0

    1 Blocks protein domain: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SNX10_HUMAN, Q9Y5X0
    Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate
    Similarity: Belongs to the sorting nexin family
    Similarity: Contains 1 PX (phox homology) domain


    Find genes that share domains with SNX10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNX10_HUMAN, Q9Y5X0
    Function: Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in
    endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins
    to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A.
    Involved in osteoclast differentiation and therefore bone resorption

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00055451-phosphatidylinositol binding IMP17012226
    GO:0035091phosphatidylinositol binding ----
    GO:0051117ATPase binding IPI--
         
    Find genes that share ontologies with SNX10           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SNX10:
     Synthetic lethal with Ras  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNX10
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNX10
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    miRNA
    Products:
        
    miRTarBase miRNAs that target SNX10:
    hsa-mir-215-5p (MIRT024587), hsa-mir-192-5p (MIRT026783)

    Block miRNA regulation of human, mouse, rat SNX10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX10 (see all 17):
    hsa-miR-30c hsa-miR-513a-5p hsa-miR-30d hsa-miR-944 hsa-miR-570 hsa-miR-141* hsa-miR-30a hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidSNX10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNX10
    Predesigned siRNA for gene silencing in human, mouse, rat SNX10

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SNX10

    Clone
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    OriGene clones in human, mouse for SNX10 (see all 6)
    OriGene ORF clones in mouse, rat for SNX10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SNX10 (NM_001199837)
    Sino Biological Human cDNA Clone for SNX10
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX10

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNX10_HUMAN, Q9Y5X0: Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm,
    cytoskeleton, microtubule organizing center, centrosome. Note=May also localize to nucleus and endoplasmic
    reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005813colocalizes with centrosome IDA--
    GO:0031313extrinsic component of endosome membrane IDA17012226

    Find genes that share ontologies with SNX10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNX10
    Interactions:

        Search GeneGlobe Interaction Network for SNX10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for SNX10 (ENSP000003437094) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIN1ENSP000002479704STRING: ENSP00000247970
    EIF1AXENSP000003689274STRING: ENSP00000368927
    EIF1AYENSP000003547224STRING: ENSP00000354722
    UBCENSP000003448184STRING: ENSP00000344818
    VPS35ENSP000002991384STRING: ENSP00000299138
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IBA--
    GO:0007032endosome organization IMP17012226
    GO:0007154cell communication ----
    GO:0015031protein transport ----
    GO:0030316osteoclast differentiation ISS--

    Find genes that share ontologies with SNX10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNX10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNX10 gene (4 alternative transcripts): 
    NM_001199835.1  NM_001199837.1  NM_001199838.1  NM_013322.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416246 ENST00000338523(uc011jzg.2 uc003sxx.3 uc010kuu.3)
    ENST00000412416 ENST00000396376(uc010kuv.3 uc010kuw.3) ENST00000409367
    ENST00000409838 ENST00000462993 ENST00000446848
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNX10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNX10 (see all 17):
    hsa-miR-30c hsa-miR-513a-5p hsa-miR-30d hsa-miR-944 hsa-miR-570 hsa-miR-141* hsa-miR-30a hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidSNX10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SNX10
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    GenScript: all cDNA clones in your preferred vector (see all 4): SNX10 (NM_001199837)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX10
    Primer
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    OriGene qPCR primer pairs and template standards for SNX10
    OriGene qSTAR qPCR primer pairs in human, mouse for SNX10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNX10
      QuantiTect SYBR Green Assays in human, mouse, rat SNX10
      QuantiFast Probe-based Assays in human, mouse, rat SNX10

    Selected AceView cDNA sequences (see all 160):

    CB112375 AA223991 AL519882 BQ787682 AV717007 AI245676 AA279300 Z40665 
    BU160208 BU630498 BQ025395 AA441938 CR612403 AI962011 AA298252 AA258005 
    CA447324 NM_013322 AA808370 Z41707 BF000784 AL533521 F07443 BC034992 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNX10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATCCAGGC
    SNX10 Expression
    About this image


    SNX10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
    SNX10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNX10 Protein Expression
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SNX10 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snx101 , 5 sorting nexin 101, 5 88.23(n)1
    95.52(a)1
      6 (24.95 cM)5
    719821  NM_028035.41  NP_082311.31 
     515239015 
    chicken
    (Gallus gallus)
    Aves SNX101 sorting nexin 10 75(n)
    76.74(a)
      420628  NM_001030986.1  NP_001026157.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNX106
    sorting nexin 10
    73(a)
    1 ↔ 1
    6(31897031-31939674)
    African clawed frog
    (Xenopus laevis)
    Amphibia BI448334.12   -- 73.52(n)    BI448334.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055622.12   -- 74.24(n)    BC055622.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNX36
    Sorting nexin required to maintain late-Golgi resi...
    25(a)
    1 → many
    XV(1009224-1009712) YOR357C


    ENSEMBL Gene Tree for SNX10 (if available)
    TreeFam Gene Tree for SNX10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNX10 gene
    SNX32  SNX112  SNX122  
    4 SIMAP similar genes for SNX10 using alignment to 8 protein entries:     SNX10_HUMAN (see all proteins):
    SNX11    SNX3    SNX12    SNX30

    Find genes that share paralogs with SNX10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNX10 (see all 1712)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0693024
    Osteopetrosis, autosomal recessive 8 (OPTB8)4--see VAR_0693022 R Q mis40--------
    VAR_0692994
    Osteopetrosis, autosomal recessive 8 (OPTB8)4--see VAR_0692992 R L mis40--------
    VAR_0693004
    Osteopetrosis, autosomal recessive 8 (OPTB8)4--see VAR_0693002 Y S mis40--------
    VAR_0693014
    Osteopetrosis, autosomal recessive 8 (OPTB8)4--see VAR_0693012 R P mis40--------
    rs676207261,2
    C--26292432(+) CTGTT-/CTGTCTT 5 -- int12Minor allele frequency- CT:0.25NA 4
    rs25627951,2
    C,F,A,H--26329554(+) CTGGGT/ATTACA 3 -- us2k14Minor allele frequency- A:0.29NA WA CSA 7
    rs1176783071,2
    C,F--26329648(+) CCTGAT/CGATCC 3 -- us2k11Minor allele frequency- C:0.09EA 120
    rs1894942611,2
    --26329733(+) ACCACC/TGTAGA 3 -- us2k10--------
    rs1924844571,2
    --26329791(+) AACCTA/GAAAAA 3 -- us2k10--------
    rs413472441,2
    C,F,H--26329808(-) CTTAAG/CTGATG 3 -- us2k123Minor allele frequency- C:0.14NS EA NA 2376

    HapMap Linkage Disequilibrium report for SNX10 (26331515 - 26413949 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SNX10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2631761CNV Insertion19546169
    esv271767CNV Insertion20981092
    nsv366364CNV Loss16902084
    nsv7393OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): SNX10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNX10
    DNA2.0 Custom Variant and Variant Library Synthesis for SNX10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614780   
    OMIM disorders: 615085  
    UniProtKB/Swiss-Prot: SNX10_HUMAN, Q9Y5X0
  • Osteopetrosis, autosomal recessive 8 (OPTB8) [MIM:615085]: A rare genetic disease characterized by
    abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe
    autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form
    occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with
    macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and
    hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves.
    OPTB8 is clinically characterized by dense bones with no distinction between outer and inner plates, due to
    extensive encroachment of cortical bone into the medullary space, increased head circumference, broad open
    fontanelle, frontal bossing, and hepatosplenomegaly. Osteoclasts number is low and their bone resorptive capacity
    is impaired. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 2 diseases for SNX10:    
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    osteopetrosis, autosomal recessive 8    osteopetrosis autosomal recessive 1

    1 disease from the University of Copenhagen DISEASES database for SNX10:
    Osteopetrosis

    Find genes that share disorders with SNX10           About GenesLikeMe

    Genetic Association Database (GAD): SNX10

    Export disorders for SNX10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNX10 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with SNX10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sorting nexin 10 induces giant vacuoles in mammalian cells. (PubMed id 17012226)1, 2, 3, 9 Qin B.... Pei D. (J. Biol. Chem. 2006)
    2. SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity. (PubMed id 23280965)1, 2 Pangrazio A.... Sobacchi C. (J. Bone Miner. Res. 2013)
    3. A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. (PubMed id 21844891)1, 2 Chen Y.... Pei D. (Cell Res. 2012)
    4. SNX10 is required for osteoclast formation and resorption activity. (PubMed id 22174188)1, 2 Zhu C.H.... Battaglino R.A. (J. Cell. Biochem. 2012)
    5. An SNX10 mutation causes malignant osteopetrosis of infancy. (PubMed id 22499339)1, 2 Aker M.... Elpeleg O. (J. Med. Genet. 2012)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)1, 2 Teasdale R.D.... Gleeson P.A. (Biochem. J. 2001)
    9. Structure of Sorting Nexin 11 (SNX11) reveals a novel extended PX Domain (PXe Domain) critical for the inhibition of Sorting Nexin 10 (SNX10) induced vacuolation. (PubMed id 23615901)1 Xu J.... Liu J. (J. Biol. Chem. 2013)
    10. Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia. (PubMed id 23123320)2 Megarbane A.... Sobacchi C. (Eur. J. Med. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29887 HGNC: 14974 AceView: SNX10 Ensembl:ENSG00000086300 euGenes: HUgn29887
    ECgene: SNX10 H-InvDB: SNX10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNX10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNX10 gene:
    Search GeneIP for patents involving SNX10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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