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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SNX10 Gene

protein-coding GIFtS: 48
GCID: GC07P026331

sorting nexin 10

Search for SNX10
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sorting Nexin 10¹ ²
OPTB8²
Sorting Nexin-10²

External Ids:	HGNC: 14974¹	Entrez Gene: 29887²	Ensembl: ENSG00000086300⁷	OMIM: 614780⁵	UniProtKB: Q9Y5X0³

Export aliases for SNX10 gene to outside databases

Previous GC identifers: GC07P025975 GC07P026073 GC07P026104 GC07P026298 GC07P026213

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNX10:

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a

phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled

coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative

splicing results in multiple transcript variants. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: SNX10_HUMAN, Q9Y5X0

Function: May be involved in several stages of intracellular trafficking (By similarity). May play a role in endosome

homeostasis. Overexpression causes formation of huge vacuoles

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SNX10 gene promoter:
TBP AP-1 POU3F2 C/EBPalpha GATA-1 GATA-2 CHOP-10 SRY NF-kappaB2 TFIID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SNX10 promoter sequence

Search SABiosciences Chromatin IP Primers for SNX10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2 Ensembl cytogenetic band: 7p15.2 HGNC cytogenetic band: 7p15.2

SNX10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNX10 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P026331: view genomic region (about GC identifiers)

Start:	26,331,515 bp from pter	End:	26,413,949 bp from pter
Size:	82,435 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 26,382,693-26,465,116

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SNX10_HUMAN, Q9Y5X0 (See protein sequence)

Recommended Name: Sorting nexin-10

Size: 201 amino acids; 23598 Da

Subcellular location: Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side

Secondary accessions: E9PFH5 Q8IYT5

Alternative splicing: 2 isoforms: Q9Y5X0-1 Q9Y5X0-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SNX10: NX_Q9Y5X0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y5X0

SNX10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001186764.1 NP_001186766.1 NP_001186767.1 NP_037454.2

ENSEMBL proteins:

ENSP00000408164 ENSP00000343709 ENSP00000393690 ENSP00000379661 ENSP00000387274

ENSP00000386540 ENSP00000395474

Human Recombinant Protein Products for SNX10:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals SNX10 Protein Novus Biologicals SNX10 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SNX10

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0031313	extrinsic to endosome membrane	IDA	17012226

SNX10 for ontologies About GeneDecksing

SNX10 Antibody Products:

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Assay Products for SNX10:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for SNX10
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	Uscn ELISAs and CLIAs for SNX10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SNX10 for domains About GeneDecksing

1 InterPro domain/family:

IPR001683 Phox

Graphical View of Domain Structure for InterPro Entry Q9Y5X0

ProtoNet protein and cluster: Q9Y5X0

1 Blocks protein family: IPB001683 Phox-like

UniProtKB/Swiss-Prot: SNX10_HUMAN, Q9Y5X0

Domain: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate

Similarity: Belongs to the sorting nexin family

Similarity: Contains 1 PX (phox homology) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SNX10_HUMAN, Q9Y5X0

Function: May be involved in several stages of intracellular trafficking (By similarity). May play a role in endosome

homeostasis. Overexpression causes formation of huge vacuoles

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005545	1-phosphatidylinositol binding	IMP	17012226
GO:0035091	phosphatidylinositol binding	--	--

SNX10 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SNX10:

Synthetic lethal with Ras

Synthetic lethal with imatinib

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SNX10

miRNA Products:		OriGene 3'-UTR Clone: SNX10 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX10
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX10 (see all 17):
		hsa-miR-30c hsa-miR-513a-5p hsa-miR-30d hsa-miR-944 hsa-miR-570 hsa-miR-141* hsa-miR-30a hsa-miR-1323

		SwitchGear 3'UTR luciferase reporter plasmid: SNX10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX10 (see all 7) OriGene shRNA RFP: SNX10 OriGene siRNA: SNX10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX10
		Sirion Biotech Custom design and validation of potent shRNA sequences against SNX10

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SNX10
			Sirion Biotech Customized adenovirus for overexpression of SNX10 Sirion Biotech Customized adenovirus for potent knockdown of SNX10

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX10 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): SNX10 (NM_001199837)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SNX10
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX10

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SNX10

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SNX10 (ENSP00000343709⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007032	endosome organization	IMP	17012226
GO:0007154	cell communication	IEA	--
GO:0015031	protein transport	IEA	--

SNX10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SNX10
Search CenterWatch for drugs/clinical trials and news about SNX10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SNX10 gene (4 alternative transcripts):

NM_001199835.1 NM_001199837.1 NM_001199838.1 NM_013322.2

Unigene Cluster for SNX10:

Sorting nexin 10

Hs.741316 [show with all ESTs]

Unigene Representative Sequence: BX648363

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000416246 ENST00000338523(uc011jzg.2 uc003sxx.3 uc010kuu.3)

ENST00000412416 ENST00000396376(uc010kuv.3 uc010kuw.3) ENST00000409367

ENST00000409838 ENST00000462993 ENST00000446848

miRNA Products:		OriGene 3'-UTR Clone: SNX10 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNX10
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SNX10 (see all 17):
		hsa-miR-30c hsa-miR-513a-5p hsa-miR-30d hsa-miR-944 hsa-miR-570 hsa-miR-141* hsa-miR-30a hsa-miR-1323

		SwitchGear 3'UTR luciferase reporter plasmid: SNX10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX10 (see all 7) OriGene shRNA RFP: SNX10 OriGene siRNA: SNX10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX10
		Sirion Biotech Custom design and validation of potent shRNA sequences against SNX10

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX10 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): SNX10 (NM_001199837)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNX10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SNX10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX10

Additional cDNA sequence:

AF121860.1 AK296142.1 AK307905.1 AK309162.1 AK311256.1 AK312850.1 AK316088.1 BC031050.1

BC034992.1 BX648363.1 NR_037670.1

10 DOTS entries:

DT.449358 DT.100775158 DT.91919321 DT.121040657 DT.121040650 DT.100024126 DT.121040639 DT.121040707

DT.121040708 DT.92436536

24/160 AceView cDNA sequences (see all 160):

F07443 T35142 AL519882 AA279300 BU630498 Z44623 AI633856 BC034992

AL533521 BF000784 Z41707 AA808370 NM_013322 BQ025395 CR612403 BQ787682

CB112375 AA258005 BU160208 AA441938 Z40665 AI962011 AV722112 CA447324

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SNX10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCATCCAGGC

About this image

SNX10 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SNX10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX10

SOURCE GeneReport for Unigene cluster: Hs.741316

SABiosciences Custom PCR Arrays for SNX10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SNX10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SNX10 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SNX10¹	sorting nexin 10	75.67(n) 76(a)		420628 NM_001030986.1 NP_001026157.1
lizard (Anolis carolinensis)	Reptilia	SNX10⁶	--	74(a)	1 ↔ 1	6(31922165-31936695)
African clawed frog (Xenopus laevis)	Amphibia	BI448334.1²	--	73.52(n)		BI448334.1
zebrafish (Danio rerio)	Actinopterygii	BC055622.1²	--	74.24(n)		BC055622.1

ENSEMBL Gene Tree for SNX10 (if available)
TreeFam Gene Tree for SNX10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SNX10 gene

SNX3² SNX11² SNX12²

4 SIMAP similar genes for SNX10 using alignment to 8 protein entries: SNX10_HUMAN (see all proteins):

SNX11 SNX3 SNX12 SNX30

SNX10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2562795^1,2	C,F,A,H	--	26329554(+)	`CTGGGT/ATTACA`	3	--	us2k¹		4		NA WA CSA	7
rs117678307^1,2	F	--	26329648(+)	`CCTGAT/CGATCC`	3	--	us2k¹		1		EA	120
rs189494261^1,2		--	26329733(+)	`ACCACC/TGTAGA`	3	--	us2k¹		0	--	--	--	--
rs192484457^1,2		--	26329791(+)	`AACCTA/GAAAAA`	3	--	us2k¹		0	--	--	--	--
rs41347244^1,2	C,F,H	--	26329808(-)	`CTTAAG/CTGATG`	3	--	us2k¹		23		NS EA NA	2376
rs141033150^1,2		--	26329817(+)	`AGTTTC/GCTGGA`	3	--	us2k¹		0	--	--	--	--
rs10243660^1,2	C	--	26330145(+)	`CCGCGC/ACCGGC`	3	--	us2k¹		2		NA	4
rs183632155^1,2		--	26330200(+)	`AAATGA/GCTTTC`	3	--	us2k¹		0	--	--	--	--
rs71521759^1,2	C	--	26330450(+)	`CTGGAG/ATGCAA`	3	--	us2k¹		1		NA	2
rs189301904^1,2		--	26330783(+)	`GTGATC/TGAGGG`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SNX10 (26331515 - 26413949 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SNX10
1 CNV: 99899
1 Indel: 12917
Human Gene Mutation Database (HGMD): SNX10

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX10

DNA2.0 Custom Variant and Variant Library Synthesis for SNX10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SNX10 for disorders About MalaCards

SNX10 for disorders About GeneDecksing

OMIM gene information: 614780 OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for SNX10:

Osteopetrosis

Export disorders for SNX10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SNX10 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with SNX10)

Utopia: connect your pdf to the dynamic
world of online information

Sorting nexin 10 induces giant vacuoles in mammalian cells. (PubMed id 17012226)^{1, 2, 3, 9} Qin B....Pei D. (2006)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
A large family of endosome-localized proteins related to sorting nexin 1. (PubMed id 11485546)^{1, 2} Teasdale R.D.... Gleeson P.A. (2001)
An SNX10 mutation causes malignant osteopetrosis of in fancy. (PubMed id 22499339)¹ Aker M....Elpeleg O. (2012)
A SNX10/V-ATPase pathway regulates ciliogenesis in vit ro and in vivo. (PubMed id 21844891)¹ Chen Y....Pei D. (2012)
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)¹ Fox C.S....Borecki I.B. (2012)
SNX10 is required for osteoclast formation and resorpt ion activity. (PubMed id 22174188)¹ Zhu C.H....Battaglino R.A. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 29887	HGNC: 14974	AceView: SNX10	Ensembl:ENSG00000086300	euGenes: HUgn29887
ECgene: SNX10	H-InvDB: SNX10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SNX10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SNX10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SNX10 gene:
Search GeneIP for patents involving SNX10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for SNX10
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX10		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX10
	OriGene Protein Over-expression Lysate for SNX10		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SNX10		OriGene 3'-UTR Clone for SNX10
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	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX10
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX10
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX10
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX10
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX10
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX10

	GenScript Custom Purified and Recombinant Proteins Services for SNX10		GenScript cDNA clones with any tag delivered in your preferred vector for SNX10
	GenScript Custom Assay Services for SNX10		GenScript Custom Superior Antibodies Services for SNX10
	GenScript Custom overexpressing Cell Line Services for SNX10		CloneReady with Over 120,000 Genes
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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SNX10 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX10

	SwitchGear 3'UTR luciferase reporter plasmids for SNX10
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Search ThermoFisher Antibodies for SNX10

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX10

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SNX10

Sirion Biotech Customized:

	stable knockdown cell line services for SNX10
	inducible knockdown cell line services for SNX10
	design and validation of potent shRNA sequences against SNX10
	adenovirus for potent knockdown of SNX10
	adenovirus for overexpression of SNX10
	stable overexpressing cell line services for SNX10
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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