External Ids for SNX10 Gene
Previous GeneCards Identifiers for SNX10 Gene
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for SNX10 Gene
SNX10 (Sorting Nexin 10) is a Protein Coding gene. Diseases associated with SNX10 include snx10-related autosomal recessive osteopetrosis and osteopetrosis, autosomal recessive 8. GO annotations related to this gene include phosphatidylinositol binding and 1-phosphatidylinositol binding. An important paralog of this gene is SNX3.
UniProtKB/Swiss-Prot for SNX10 Gene
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.