SNX1 Gene
protein-coding GIFtS: 60
GCID: GC15P064474
|
|
sorting nexin 1
| |
Aliases
for SNX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sorting Nexin 11 2 | | Vps51 | | HsT173791 2 | | VPS52 | | SNX1A1 5 | | Sorting Nexin 1A2 | | MGC86641 | | Sorting Nexin-12 |
Export aliases for SNX1 gene to outside databasesPrevious GC identifers: GC15P060175 GC15P057547 GC15P061964 GC15P062104 GC15P062175 GC15P064388 GC15P041212 |
Summaries
for SNX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNX1:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates thecell-surface expression of epidermal growth factor receptor. This protein also has a role in sortingprotease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes withfamily members. This gene results in three transcript variants encoding distinct isoforms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: SNX1_HUMAN, Q13596Function: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activatedEGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component ofthe retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to thetrans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) orphosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)
Gene Wiki entry for SNX1
|
Genomic Views
for SNX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNX1 gene promoter:
ER-alpha AML1a Chx10 STAT3 MIF-1 IRF-1 NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22.31 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q22.31SNX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P064474: view genomic region
(about GC identifiers)
Start:
|
64,386,322 bp from pter |
End:
|
64,438,289 bp from pter |
Size:
|
51,968 bases |
Orientation:
|
plus strand |
|
Proteins
for SNX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNX1_HUMAN, Q13596 (See
protein sequence)Recommended Name: Sorting nexin-1 Size: 522 amino acids; 59070 Da
Subunit: Homodimer. Self-assembles into a complex of approximately 300 kDa (By similarity). Interacts with HGS (Bysimilarity). Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2.Interacts with SNX6
Subcellular location: Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golginetwork membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Early endosome membrane; Peripheralmembrane protein; Cytoplasmic side. Note=Enriched on tubular elements of the early endosome membrane. Bindspreferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) orphosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)
Miscellaneous: Binds phosphatidylinositol 3-phosphate (PtdIns-(3)P) and phosphatidylinositol 3,5-bisphosphate(PtdIns-(3,5)P2) in liposome-based assays. Can bind PtdIns(3,4,5)P3 in protein:lipid overlay assays, but not inliposome-based assays
1 PDB 3D structure from  and Proteopedia  for SNX1:2I4K (3D)
Secondary accessions: A6NM19 A8K6T7 H0Y2M5 O60750 O60751 Q6ZRJ8Alternative splicing: 3 isoforms: Q13596-1 Q13596-2 Q13596-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SNX1: NX_Q13596
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13596
SNX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001229862.1 NP_003090.2 NP_683758.1
ENSEMBL proteins: ENSP00000452651 ENSP00000452652 ENSP00000369638 ENSP00000261889 ENSP00000453785 ENSP00000452759 ENSP00000453567 ENSP00000452668 ENSP00000452852 ENSP00000452931 ENSP00000326668
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
SNX1 for ontologies About GeneDecksing
SNX1 Antibody Products:
Assay Products for SNX1: |
Protein
Domains /
Families
for SNX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNX1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13596ProtoNet protein and cluster: Q13596 2 Blocks protein families: IPB001683 Phox-like IPB005329 Sorting nexin
UniProtKB/Swiss-Prot: SNX1_HUMAN, Q13596Similarity: Belongs to the sorting nexin familySimilarity: Contains 1 BAR domainSimilarity: Contains 1 PX (phox homology) domain |
Function
for SNX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNX1_HUMAN, Q13596Function: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activatedEGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component ofthe retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to thetrans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) orphosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) Genatlas biochemistry entry for SNX1:sorting nexin 1,sorting the internalized receptors from endosome to lysosome
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): SNX1 (NM_148955) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
SNX1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SNX1:
Animal Models:
Mouse knock-out Snx1tm1Mag for SNX1
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Snx1):
SNX1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SNX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TGF-beta Receptor Signaling Pathway | |
1  BioSystems Pathway for SNX1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNX1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/79 Interacting proteins for SNX1 (Q135962, 3 ENSP000003696384) via UniProtKB, MINT, STRING, and/or I2D (see all 79)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
SNX1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SNX1 for compounds About GeneDecksing
 Browse Tocris compounds for SNX1
6 Novoseek chemical compound relationships for SNX1 gene About this table
Search CenterWatch for drugs/clinical trials and news about SNX1
|
Transcripts
for SNX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNX1 gene (4 alternative transcripts): NM_001242933.1 NM_003099.4 NM_148955.3 NM_152826.2 Unigene Cluster for SNX1: Sorting nexin 1 Hs.188634 [show with all ESTs]Unigene Representative Sequence: NM_00309914 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000560829 ENST00000559061 ENST00000380285(uc010uio.2 uc002amv.3 uc002amx.3 uc010bgw.3)
ENST00000261889 ENST00000559844 ENST00000560260(uc010bgv.3) ENST00000561026
ENST00000558040 ENST00000559389 ENST00000559401 ENST00000559339 ENST00000559961
ENST00000560861 ENST00000353874
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SNX1 (NM_148955) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX1 |
Additional cDNA sequence: AB209013.1 AF065483.1 AF065484.1 AF131792.1 AK128179.1 AK222561.1 AK222793.1 AK291752.1 AK310618.1 AL050148.1 BC000357.2 BT006983.1 EF491792.1 22 DOTS entries: DT.100825881 DT.447237 DT.100825882 DT.40203300 DT.97790236 DT.100825880 DT.100825887 DT.121063159 DT.95150461 DT.75117082 DT.452365 DT.95163072 DT.100029329 DT.121063149 DT.423081 DT.91725047 DT.91764053 DT.91764054 DT.91764058 DT.91944820 DT.95163058 DT.95300053 24/377 AceView cDNA sequences (see all 377): CD723957 AL599039 BQ226990 BQ084047 BQ435224 AL559551 BM698981 BF109062 BQ226898 AA761352 T33691 BM980888 BX470922 CR620387 AI500037 AW173624 CB162104 BQ425109 AL554627 BQ935515 BQ278802 BX108623 AL552422 CA442883
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SNX1 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SNX1
|
Expression
for SNX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAGGTTAT
About this image
See SNX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNX1
SOURCE GeneReport for Unigene cluster: Hs.188634
SABiosciences Custom PCR Arrays for SNX1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX1 |
Orthologs
for SNX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SNX1 gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SNX11 |
sorting nexin 1 |
78.6(n)
84.93(a) |
|
427480 XM_425052.3 XP_425052.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SNX16 |
-- |
82(a) |
1 ↔ 1 |
GL343490.1(375982-389023) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
BX732624.12 |
-- |
77.66(n) |
|
BX732624.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
snx1a1 |
sorting nexin 1a |
68.07(n)
74.05(a) |
|
337386 NM_001128671.2 NP_001122143.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG27743 |
intracellular protein transport |
42(a) |
|
23F3 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
C05D9.13 |
-- |
36(a) |
|
X(1164317-1167717) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SNX2b6SNX2a6 |
sorting nexin 2A |
19(a)18(a) |
many ↔ manymany ↔ many |
5(2206894-2209516) 5(23623858-23626787) |
rice
(Oryza sativa) |
Liliopsida |
---- |
phox domain-containing protein, putative, expresse...phox domain-containing protein, putative, expresse... |
18(a)16(a) |
many ↔ manymany ↔ many |
5(16231726-16239175) 1(35395123-35399205) |
ENSEMBL Gene Tree for SNX1 (if available)
TreeFam Gene Tree for SNX1 (if available) |
Paralogs
for SNX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNX1 gene
- SNX62 SNX22 SNX322 SNX52
6 SIMAP similar genes for SNX1 using alignment to 9 protein entries: SNX1_HUMAN (see all proteins):CERS5 GYG2P1 NRAMP1 SNX2 SNX3 SNX12
SNX1 for paralogs About GeneDecksing
|
Genomic Variants
for SNX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNX1 (64386322 - 64438289 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNX1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX1 |
|
Disorders
/ Diseases
for SNX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNX1 for disorders About GeneDecksing
OMIM gene information: 601272
OMIM disorders: --
6  diseases for SNX1: About MalaCardsmacular degeneration epithelial ovarian cancer ovarian cancer lung cancer
ataxia carcinoma
Export disorders for SNX1 gene to outside databases
|
Publications
for SNX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNX1 gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with SNX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Enhanced degradation of EGF receptors by a sorting nexin, SNX1. (PubMed id 8638121)1, 2, 3, 9 Kurten R.C.... Gill G.N. (1996)
- Endosomal localization and function of sorting nexin 1. (PubMed id 11997453)1, 2, 9 Zhong Q.... Gill G.N. (2002)
- The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. (PubMed id 12198132)1, 2, 9 Cozier G.E....Cullen P.J. (2002)
- Identification of a family of sorting nexin molecules and characterization of their association with receptors. (PubMed id 9819414)1, 2, 9 Haft C.R.... Taylor S.I. (1998)
- Determinants of the endosomal localization of sorting nexin 1. (PubMed id 15673616)1, 2, 9 Zhong Q....Gill G.N. (2005)
- Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. (PubMed id 17101778)1, 2, 9 Rojas R....Bonifacino J.S. (2007)
- Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. (PubMed id 15498486)1, 2 Carlton J....Cullen P.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structural and functional characterization of the human gene for sorting nexin 1 (SNX1). (PubMed id 11410165)1, 9 Shank B.B....Kurten R.C. (2001)
- Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent. (PubMed id 20070609)1, 9 Nisar S....Mundell S.J. (2010)
|
External Searches for SNX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNX1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNX1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNX1 gene:
Search GeneIP for patents involving SNX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SNX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for SNX1 | | OriGene shRNA RFP for SNX1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNX1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNX1 | | | OriGene Protein Over-expression Lysate for SNX1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SNX1 | | OriGene 3'-UTR Clone for SNX1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNX1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNX1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SNX1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SNX1 | | OriGene Custom Protein Services for SNX1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNX1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNX1 |
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| | | | Search Tocris compounds for SNX1 |
| |  |  |  |  | | | | | | Recombinant Protein for SNX1 |
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 | | | SNX1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNX1 |
|  |  |  | | | | ThermoFisher Antibody for SNX1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNX1 |
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