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Aliases for SNX1 Gene

Aliases for SNX1 Gene

  • Sorting Nexin 1 2 3 5
  • Sorting Nexin 1A 3
  • HsT17379 3
  • VPS5 3

External Ids for SNX1 Gene

Previous GeneCards Identifiers for SNX1 Gene

  • GC15P060175
  • GC15P057547
  • GC15P061964
  • GC15P062104
  • GC15P062175
  • GC15P064388
  • GC15P041212
  • GC15P064474
  • GC15P064875
  • GC15P065757

Summaries for SNX1 Gene

Entrez Gene Summary for SNX1 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX1 Gene

SNX1 (Sorting Nexin 1) is a Protein Coding gene. Among its related pathways are TGF-beta Receptor Signaling Pathway and Endocytosis. GO annotations related to this gene include identical protein binding and insulin receptor binding. An important paralog of this gene is SNX5.

UniProtKB/Swiss-Prot for SNX1 Gene

  • Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).

Gene Wiki entry for SNX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX1 Gene

Genomics for SNX1 Gene

Regulatory Elements for SNX1 Gene

Enhancers for SNX1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNX1 Gene

Chromosome:
15
Start:
64,094,076 bp from pter
End:
64,146,090 bp from pter
Size:
52,015 bases
Orientation:
Plus strand

Genomic View for SNX1 Gene

Genes around SNX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX1 Gene

Proteins for SNX1 Gene

  • Protein details for SNX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13596-SNX1_HUMAN
    Recommended name:
    Sorting nexin-1
    Protein Accession:
    Q13596
    Secondary Accessions:
    • A6NM19
    • A8K6T7
    • H0Y2M5
    • O60750
    • O60751
    • Q6ZRJ8

    Protein attributes for SNX1 Gene

    Size:
    522 amino acids
    Molecular mass:
    59070 Da
    Quaternary structure:
    • Predominantly forms heterodimers with BAR domain-containing sorting nexins SNX5, SNX6 and SNX32; can self-associate to form homodimers (PubMed:23085988). The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS) and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity (Probable). Interacts with SNX5, SNX6, SNX32, VPS26A, VPS29, VPS35, DRD5, DENND5A, KALRN, RHOG (GDP-bound form) (PubMed:9819414, PubMed:11102511, PubMed:19619496, PubMed:19935774, PubMed:19619496, PubMed:20604901, PubMed:23085988, PubMed:23152498). The interaction with SNX2 is reported controversially (PubMed:9819414, PubMed:11997453, PubMed:19619496, PubMed:23085988). Interacts with DNAJC13; prevented by presence of HGS (PubMed:19874558). Interacts with HGS (By similarity).
    Miscellaneous:
    • Binds phosphatidylinositol 3-phosphate (PtdIns-(3)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2) in liposome-based assays. Can bind PtdIns(3,4,5)P3 in protein:lipid overlay assays, but not in liposome-based assays.

    Three dimensional structures from OCA and Proteopedia for SNX1 Gene

    Alternative splice isoforms for SNX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX1 Gene

Proteomics data for SNX1 Gene at MOPED

Post-translational modifications for SNX1 Gene

  • Ubiquitination at Lys 286
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SNX1 Gene

Domains & Families for SNX1 Gene

Gene Families for SNX1 Gene

Protein Domains for SNX1 Gene

Suggested Antigen Peptide Sequences for SNX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13596

UniProtKB/Swiss-Prot:

SNX1_HUMAN :
  • The BAR domain is able to sense membrane curvature upon dimerization (PubMed:19816406). Membrane remodeling seems to implicate insertion of a N-terminal amphipatric helix (AH) in the membrane (Probable).
  • Belongs to the sorting nexin family.
Domain:
  • The BAR domain is able to sense membrane curvature upon dimerization (PubMed:19816406). Membrane remodeling seems to implicate insertion of a N-terminal amphipatric helix (AH) in the membrane (Probable).
  • Contains 1 BAR domain.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX1: view

Function for SNX1 Gene

Molecular function for SNX1 Gene

GENATLAS Biochemistry:
sorting nexin 1,sorting the internalized receptors from endosome to lysosome
UniProtKB/Swiss-Prot Function:
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).

Gene Ontology (GO) - Molecular Function for SNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11102511
genes like me logo Genes that share ontologies with SNX1: view
genes like me logo Genes that share phenotypes with SNX1: view

Animal Models for SNX1 Gene

MGI Knock Outs for SNX1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNX1 Gene

Localization for SNX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX1 Gene

Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalizes with DNAJC13 and Shiginella dysenteria toxin stxB on early endosomes (PubMed:19874558). Colocalized with F-actin at the leading edge of lamellipodia in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269 PubMed:15498486, ECO:0000269 PubMed:18088323, ECO:0000269 PubMed:20604901}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNX1 Gene COMPARTMENTS Subcellular localization image for SNX1 gene
Compartment Confidence
endosome 5
cytosol 4
golgi apparatus 4
lysosome 2
nucleus 2
vacuole 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol IEA --
GO:0030027 lamellipodium IEA --
GO:0030904 retromer complex IEA,IDA 19619496
GO:0043234 protein complex IDA 9819414
genes like me logo Genes that share ontologies with SNX1: view

Pathways & Interactions for SNX1 Gene

genes like me logo Genes that share pathways with SNX1: view

Pathways by source for SNX1 Gene

1 BioSystems pathway for SNX1 Gene
1 KEGG pathway for SNX1 Gene

Gene Ontology (GO) - Biological Process for SNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016050 vesicle organization IBA --
genes like me logo Genes that share ontologies with SNX1: view

No data available for SIGNOR curated interactions for SNX1 Gene

Drugs & Compounds for SNX1 Gene

(1) Drugs for SNX1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for SNX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNX1: view

Transcripts for SNX1 Gene

Unigene Clusters for SNX1 Gene

Sorting nexin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNX1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - - -
SP7:

Relevant External Links for SNX1 Gene

GeneLoc Exon Structure for
SNX1
ECgene alternative splicing isoforms for
SNX1

Expression for SNX1 Gene

mRNA expression in normal human tissues for SNX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNX1 Gene



SOURCE GeneReport for Unigene cluster for SNX1 Gene Hs.188634

genes like me logo Genes that share expression patterns with SNX1: view

Protein tissue co-expression partners for SNX1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNX1 Gene

Orthologs for SNX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNX1 35
  • 93.81 (n)
  • 96.55 (a)
SNX1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNX1 35
  • 94.24 (n)
  • 98.08 (a)
SNX1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx1 35
  • 89.96 (n)
  • 94.43 (a)
Snx1 16
Snx1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNX1 35
  • 99.68 (n)
  • 99.81 (a)
SNX1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snx1 35
  • 90.04 (n)
  • 95.02 (a)
oppossum
(Monodelphis domestica)
Mammalia SNX1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX1 35
  • 78.95 (n)
  • 85.1 (a)
SNX1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNX1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx1 35
  • 71.25 (n)
  • 78.49 (a)
zebrafish
(Danio rerio)
Actinopterygii snx1a 35
  • 68.15 (n)
  • 74.21 (a)
snx1a 36
  • 55 (a)
OneToMany
snx1b 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG2774 37
  • 42 (a)
Snx1 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C05D9.1 37
  • 36 (a)
snx-1 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX4 36
  • 16 (a)
OneToMany
VPS5 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for SNX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX1 Gene

ENSEMBL:
Gene Tree for SNX1 (if available)
TreeFam:
Gene Tree for SNX1 (if available)

Paralogs for SNX1 Gene

Paralogs for SNX1 Gene

genes like me logo Genes that share paralogs with SNX1: view

Variants for SNX1 Gene

Sequence variations from dbSNP and Humsavar for SNX1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1802376 - 64,136,360(+) AAAGG(A/G)ACTTC reference, missense
rs1049501 - 64,118,189(+) CATTT(A/C)TCTTC intron-variant, reference, missense, utr-variant-5-prime
rs9664 -- 64,137,819(+) AGAAT(A/G)GTTTC intron-variant, utr-variant-3-prime
rs332255 -- 64,099,061(+) CAATA(A/C)ATGCT intron-variant
rs332256 -- 64,097,544(+) AAGTT(C/T)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNX1 Gene

Variant ID Type Subtype PubMed ID
nsv833036 CNV Loss 17160897
esv273472 CNV Insertion 20981092
esv2560472 CNV Deletion 19546169

Variation tolerance for SNX1 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SNX1 Gene

Disorders for SNX1 Gene

Relevant External Links for SNX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNX1

No disorders were found for SNX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX1 Gene

Publications for SNX1 Gene

  1. Enhanced degradation of EGF receptors by a sorting nexin, SNX1. (PMID: 8638121) Kurten R.C. … Gill G.N. (Science 1996) 2 3 4 23 67
  2. Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent. (PMID: 20070609) Nisar S. … Mundell S.J. (Traffic 2010) 3 23
  3. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. (PMID: 19619496) Wassmer T. … Cullen P.J. (Dev. Cell 2009) 3 23
  4. Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes. (PMID: 19874558) Popoff V. … Johannes L. (Traffic 2009) 3 23
  5. SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. (PMID: 18088323) Mari M. … Geuze H.J. (Traffic 2008) 3 23

Products for SNX1 Gene

Sources for SNX1 Gene

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