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SNW1 Gene(Protein Coding)

SNW Domain Containing 1

GCID:
GC14M077717
GIFtS:
63
Genes Participants
UDN Logo

Aliases for SNW1 Gene

Aliases for SNW1 Gene

  • SNW Domain Containing 1 2 3 5
  • Nuclear Receptor Coactivator NCoA-62 3 4
  • SKI Interacting Protein 2 3
  • Nuclear Protein SkiP 3 4
  • SKIIP 3 4
  • SKIP 3 4
  • Nuclear Receptor Coactivator, 62-KD 3
  • Homolog Of Drosophila BX42 3
  • SKI-Interacting Protein 3
  • Ski-Interacting Protein 4
  • NCOA-62 3
  • PRPF45 3
  • Prp45 3
  • Bx42 3

External Ids for SNW1 Gene

Previous HGNC Symbols for SNW1 Gene

  • SKIIP

Previous GeneCards Identifiers for SNW1 Gene

  • GC14M075689
  • GC14M072000
  • GC14M076173
  • GC14M077254
  • GC14M078183
  • GC14M058349

Summaries for SNW1 Gene

Entrez Gene Summary for SNW1 Gene

  • This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for SNW1 Gene

SNW1 (SNW Domain Containing 1) is a Protein Coding gene. Among its related pathways are Epstein-Barr virus infection and Notch signaling pathway (KEGG). GO annotations related to this gene include poly(A) RNA binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for SNW1 Gene

  • Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA.

Gene Wiki entry for SNW1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNW1 Gene

Genomics for SNW1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SNW1 Gene

Enhancers for SNW1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNW1 on UCSC Golden Path with GeneCards custom track

Promoters for SNW1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNW1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SNW1 gene promoter:

Genomic Location for SNW1 Gene

Chromosome:
14
Start:
77,717,599 bp from pter
End:
77,761,218 bp from pter
Size:
43,620 bases
Orientation:
Minus strand

Genomic View for SNW1 Gene

Genes around SNW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNW1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SNW1 Gene

Proteins for SNW1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SNW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13573-SNW1_HUMAN
    Recommended name:
    SNW domain-containing protein 1
    Protein Accession:
    Q13573
    Secondary Accessions:
    • A8K8A9
    • Q13483
    • Q32N03
    • Q5D0D6

    Protein attributes for SNW1 Gene

    Size:
    536 amino acids
    Molecular mass:
    61494 Da
    Quaternary structure:
    • Interacts SKI, SMAD2,SMAD3, RBPJ, RB1, PABPN1, MAGEA1, SIRT1, FOXN3, U2AF2, PPIL1, DAXX and ATP1B4. Interacts with VDR and RXRA; preferentially associates with VDR:RXRA heterodimers. Interacts with NCOR2 and EBV EBNA2; NCOR2 and EBV EBNA2 compete for interaction with SNW1. Interacts with MAML1. Interacts with NOTCH1 NICD; the interaction involves multimerized NOTCH1 NICD. Forms a complex with NOTCH1 NICD and MAML1; the association is dissociated by RBPJ. Identified in the spliceosome C complex. Associates with U4/U6-U5 tri-small nuclear ribonucleoproteins (U4/U6-U5 tri-snRNPs). Associates with positive transcription elongation factor b (P-TEFb). Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Interacts with human papillomavirus type-16 (HPV16) E7 protein.

neXtProt entry for SNW1 Gene

Proteomics data for SNW1 Gene at MOPED

Protein Expression for SNW1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SNW1 Gene

  • Ubiquitination at Lys 193 and Lys 416
  • Modification sites at PhosphoSitePlus

Other Protein References for SNW1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SNW1 Gene

Domains & Families for SNW1 Gene

Protein Domains for SNW1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13573

UniProtKB/Swiss-Prot:

SNW1_HUMAN :
  • Belongs to the SNW family.
Family:
  • Belongs to the SNW family.
genes like me logo Genes that share domains with SNW1: view

No data available for Gene Families for SNW1 Gene

Function for SNW1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for SNW1 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA.

Gene Ontology (GO) - Molecular Function for SNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005112 Notch binding IPI 10713164
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0046332 SMAD binding IDA 11278756
genes like me logo Genes that share ontologies with SNW1: view

Phenotypes for SNW1 Gene

GenomeRNAi human phenotypes for SNW1:
genes like me logo Genes that share phenotypes with SNW1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SNW1

CRISPR Products

miRNA for SNW1 Gene

miRTarBase miRNAs that target SNW1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNW1 Gene

Localization for SNW1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNW1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNW1 Gene COMPARTMENTS Subcellular localization image for SNW1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA,TAS --
GO:0005681 spliceosomal complex IEA,IDA 15194481
GO:0071141 SMAD protein complex IEA --
genes like me logo Genes that share ontologies with SNW1: view

Pathways & Interactions for SNW1 Gene

genes like me logo Genes that share pathways with SNW1: view

SIGNOR curated interactions for SNW1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for SNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14985122
GO:0000398 mRNA splicing, via spliceosome IEA,IDA 15194481
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0016032 viral process IEA --
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA 11278756
genes like me logo Genes that share ontologies with SNW1: view

Drugs & Compounds for SNW1 Gene

Products:

  1. Drug

(1) Drugs for SNW1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SNW1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNW1: view

Transcripts for SNW1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for SNW1 Gene

(4) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(357) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNW1 Gene

SNW domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNW1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1:
SP2:

Relevant External Links for SNW1 Gene

GeneLoc Exon Structure for
SNW1
ECgene alternative splicing isoforms for
SNW1

Expression for SNW1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for SNW1 Gene

mRNA expression in normal human tissues for SNW1 Gene
mRNA expression by BioGPS for SNW1 GenemRNA expression by GTEx for SNW1 Gene

Protein differential expression in normal tissues from HIPED for SNW1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.8), Urine (10.8), and Testis (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNW1 Gene



SOURCE GeneReport for Unigene cluster for SNW1 Gene Hs.445498

genes like me logo Genes that share expression patterns with SNW1: view

Protein tissue co-expression partners for SNW1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNW1 Gene

Orthologs for SNW1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNW1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia SNW1 35
  • 94.15 (n)
  • 99.63 (a)
SNW1 36
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SNW1 35
  • 94.53 (n)
  • 99.63 (a)
-- 36
  • 99 (a)
 OneToMany
-- 36
  • 99 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Snw1 35
  • 92.23 (n)
  • 99.25 (a)
Snw1 16
Snw1 36
  • 99 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia SNW1 35
  • 99.56 (n)
  • 100 (a)
SNW1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Snw1 35
  • 91.36 (n)
  • 99.07 (a)
oppossum
(Monodelphis domestica)
 Mammalia SNW1 36
  • 99 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia SNW1 36
  • 98 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves SNW1 35
  • 83.33 (n)
  • 95.71 (a)
SNW1 36
  • 95 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SNW1 36
  • 96 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia snw1 35
  • 77.13 (n)
  • 88.97 (a)
Str.6904 35
African clawed frog
(Xenopus laevis)
 Amphibia Xl.28747 35
zebrafish
(Danio rerio)
 Actinopterygii snw1 35
  • 76.34 (n)
  • 84.83 (a)
snw1 36
  • 87 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Bx42 37
  • 62 (a)
Bx42 35
  • 60.76 (n)
  • 64.76 (a)
Bx42 36
  • 60 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP004521 35
  • 64.12 (n)
  • 68.88 (a)
worm
(Caenorhabditis elegans)
 Secernentea skp-1 35
  • 60.15 (n)
  • 60.08 (a)
skp-1 36
  • 56 (a)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PRP45 36
  • 31 (a)
 OneToOne
PRP45 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons SKIP 35
  • 57.74 (n)
  • 53.17 (a)
barley
(Hordeum vulgare)
 Liliopsida Hv.2879 35
rice
(Oryza sativa)
 Liliopsida Os.19400 35
Os02g0759800 35
  • 56.66 (n)
  • 58.14 (a)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.4259 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU03799 35
  • 55.56 (n)
  • 52.53 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes prp45 35
  • 54.24 (n)
  • 50.51 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.2170 36
  • 66 (a)
 OneToOne
Species with no ortholog for SNW1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNW1 Gene

ENSEMBL:
Gene Tree for SNW1 (if available)
TreeFam:
Gene Tree for SNW1 (if available)

Paralogs for SNW1 Gene

Pseudogenes.org Pseudogenes for SNW1 Gene

genes like me logo Genes that share paralogs with SNW1: view

No data available for Paralogs for SNW1 Gene

Variants for SNW1 Gene

Sequence variations from dbSNP and Humsavar for SNW1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs114763 -- 77,731,022(+) CTTCT(C/T)TCCCT reference, synonymous-codon
rs176960 -- 77,718,223(+) AACTG(A/C)ACTGG reference, synonymous-codon, missense, utr-variant-3-prime
rs176961 -- 77,719,085(+) atttt(C/T)tgtag intron-variant
rs176962 -- 77,719,167(+) aagtg(C/T)tagga intron-variant
rs176963 -- 77,719,946(+) GCGCA(C/T)GCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNW1 Gene

Variant ID Type Subtype PubMed ID
dgv643e1 CNV Complex 17122850
essv7944 CNV CNV 17122850
esv34940 CNV Gain 17911159
nsv521287 CNV Gain 19592680
nsv520021 CNV Gain 19592680
nsv519957 CNV Loss 19592680
esv1469738 CNV Insertion 17803354

Variation tolerance for SNW1 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNW1 Gene

HapMap Linkage Disequilibrium report
SNW1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNW1 Gene

Disorders for SNW1 Gene

Relevant External Links for SNW1

Genetic Association Database (GAD)
SNW1
Human Genome Epidemiology (HuGE) Navigator
SNW1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNW1

No disorders were found for SNW1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNW1 Gene

Publications for SNW1 Gene

  1. Isolation and characterization of a novel coactivator protein, NCoA- 62, involved in vitamin D-mediated transcription. (PMID: 9632709) Baudino T.A. … Macdonald P.N. (J. Biol. Chem. 1998) 2 3 4 67
  2. Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells. (PMID: 19934264) Kang M.R. … Um S.J. (Nucleic Acids Res. 2010) 3 23
  3. A large intrinsically disordered region in SKIP and its disorder- order transition induced by PPIL1 binding revealed by NMR. (PMID: 20007319) Wang X. … Shi Y. (J. Biol. Chem. 2010) 3 23
  4. The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. (PMID: 20368803) Stegmann C.M. … Wahl M.C. (PLoS ONE 2010) 3 23
  5. SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation. (PMID: 19818711) Bres V. … Jones K.A. (Mol. Cell 2009) 3 23

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