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SNW1 Gene(Protein Coding)

SNW Domain Containing 1

GCID:
GC14M077717
GIFtS:
60
Genes Participants
UDN Logo

Aliases for SNW1 Gene

Aliases for SNW1 Gene

  • SNW Domain Containing 1 2 3 5
  • Nuclear Receptor Coactivator NCoA-62 3 4
  • SKI Interacting Protein 2 3
  • Ski-Interacting Protein 3 4
  • Nuclear Protein SkiP 3 4
  • SKIIP 3 4
  • SKIP 3 4
  • Nuclear Receptor Coactivator, 62-KD 3
  • SNW Domain-Containing Protein 1 3
  • Homolog Of Drosophila BX42 3
  • NCOA-62 3
  • PRPF45 3
  • Prp45 3
  • Bx42 3

External Ids for SNW1 Gene

Previous HGNC Symbols for SNW1 Gene

  • SKIIP

Previous GeneCards Identifiers for SNW1 Gene

  • GC14M075689
  • GC14M072000
  • GC14M076173
  • GC14M077254
  • GC14M078183
  • GC14M058349

Summaries for SNW1 Gene

Entrez Gene Summary for SNW1 Gene

  • This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for SNW1 Gene

SNW1 (SNW Domain Containing 1) is a Protein Coding gene. Among its related pathways are Signaling by NOTCH1 and mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for SNW1 Gene

  • Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA.

Gene Wiki entry for SNW1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNW1 Gene

Genomics for SNW1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SNW1 Gene

Enhancers for SNW1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G076767 1.4 Ensembl ENCODE dbSUPER 23 +992.7 992733 2.2 PKNOX1 ZFP64 TCF12 IKZF2 CREM ZNF426 REST ZNF518A ZNF781 NR2F2 ZMYND19P1 SNW1 RPL22P2 ALKBH1 ENSG00000259081 IRF2BPL VASH1 POMT2 NGB RPL21P10
GH14G077614 1.3 ENCODE dbSUPER 24.3 +145.0 144996 2.7 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SNW1 ADCK1 RPL22P2 ALKBH1 SPTLC2 ZMYND19P1 RN7SL587P
GH14G077588 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.1 +169.7 169659 7.0 NFIB ZFP64 BMI1 ZNF121 GATA2 CBX5 RELB ETV6 IKZF2 ZBTB11 SPTLC2 ADCK1 SNW1 RPL22P2 POMT2 ZMYND19P1 VASH1 ENSG00000259081 NGB ALKBH1
GH14G076902 1.5 Ensembl ENCODE dbSUPER 14.4 +856.9 856853 3.7 PKNOX1 FOXA2 ARNT WRNIP1 SIN3A FEZF1 ZBTB7B GTF3C2 GLIS2 ELK1 ZMYND19P1 RPL22P2 SNW1 ALKBH1 RPL21P10 PIR46005 ENSG00000259058
GH14G077580 1.4 Ensembl ENCODE dbSUPER 12.3 +179.4 179396 2.8 PKNOX1 NFIB ZFP64 FEZF1 TCF12 GATA2 ZNF366 RELB CREM ZNF362 SPTLC2 RPL22P2 SNW1 ZMYND19P1 VASH1 ENSG00000259081 NGB ALKBH1 RPL21P10 ANGEL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNW1 on UCSC Golden Path with GeneCards custom track

Promoters for SNW1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000071198 218 2001 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 SP5

Transcription factor binding sites by QIAGEN in the SNW1 gene promoter:

Genomic Location for SNW1 Gene

Chromosome:
14
Start:
77,717,599 bp from pter
End:
77,761,218 bp from pter
Size:
43,620 bases
Orientation:
Minus strand

Genomic View for SNW1 Gene

Genes around SNW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNW1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SNW1 Gene

Proteins for SNW1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SNW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13573-SNW1_HUMAN
    Recommended name:
    SNW domain-containing protein 1
    Protein Accession:
    Q13573
    Secondary Accessions:
    • A8K8A9
    • Q13483
    • Q32N03
    • Q5D0D6

    Protein attributes for SNW1 Gene

    Size:
    536 amino acids
    Molecular mass:
    61494 Da
    Quaternary structure:
    • Interacts SKI, SMAD2,SMAD3, RBPJ, RB1, PABPN1, MAGEA1, SIRT1, FOXN3, U2AF2, PPIL1, DAXX and ATP1B4. Interacts with VDR and RXRA; preferentially associates with VDR:RXRA heterodimers. Interacts with NCOR2 and EBV EBNA2; NCOR2 and EBV EBNA2 compete for interaction with SNW1. Interacts with MAML1. Interacts with NOTCH1 NICD; the interaction involves multimerized NOTCH1 NICD. Forms a complex with NOTCH1 NICD and MAML1; the association is dissociated by RBPJ. Identified in the spliceosome C complex. Associates with U4/U6-U5 tri-small nuclear ribonucleoproteins (U4/U6-U5 tri-snRNPs). Associates with positive transcription elongation factor b (P-TEFb). Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Interacts with human papillomavirus type-16 (HPV16) E7 protein.

neXtProt entry for SNW1 Gene

Protein Expression for SNW1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SNW1 Gene

  • Ubiquitination at isoforms=193 and isoforms=416
  • Modification sites at PhosphoSitePlus

Other Protein References for SNW1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SNW1 Gene

Domains & Families for SNW1 Gene

Protein Domains for SNW1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13573

UniProtKB/Swiss-Prot:

SNW1_HUMAN :
  • Belongs to the SNW family.
Family:
  • Belongs to the SNW family.
genes like me logo Genes that share domains with SNW1: view

No data available for Gene Families for SNW1 Gene

Function for SNW1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for SNW1 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA.

Gene Ontology (GO) - Molecular Function for SNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 11514567
GO:0003714 transcription corepressor activity IDA 14985122
GO:0003723 RNA binding IDA 22681889
GO:0005112 Notch binding IPI 10713164
GO:0005515 protein binding IPI 9569025
genes like me logo Genes that share ontologies with SNW1: view
genes like me logo Genes that share phenotypes with SNW1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SNW1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNW1 Gene

Localization for SNW1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNW1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNW1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA,IEA 9569025
GO:0005654 nucleoplasm IDA,TAS --
GO:0005681 spliceosomal complex IEA,IDA 15194481
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SNW1: view

Pathways & Interactions for SNW1 Gene

genes like me logo Genes that share pathways with SNW1: view

SIGNOR curated interactions for SNW1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for SNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14985122
GO:0000350 generation of catalytic spliceosome for second transesterification step IBA --
GO:0000398 mRNA splicing, via spliceosome IEA,TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SNW1: view

Drugs & Compounds for SNW1 Gene

Products:

  1. Drug

(1) Drugs for SNW1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SNW1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNW1: view

Transcripts for SNW1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SNW1 Gene

(3) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(357) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNW1 Gene

SNW domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNW1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1:
SP2:

Relevant External Links for SNW1 Gene

GeneLoc Exon Structure for
SNW1
ECgene alternative splicing isoforms for
SNW1

Expression for SNW1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNW1 Gene

mRNA expression in normal human tissues for SNW1 Gene
mRNA expression by BioGPS for SNW1 GenemRNA expression by GTEx for SNW1 Gene

Protein differential expression in normal tissues from HIPED for SNW1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.8), Urine (10.8), and Testis (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNW1 Gene



Protein tissue co-expression partners for SNW1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNW1 Gene:

SNW1

SOURCE GeneReport for Unigene cluster for SNW1 Gene:

Hs.445498

Evidence on tissue expression from TISSUES for SNW1 Gene

  • Liver(4.5)
  • Nervous system(4.5)
  • Lung(2.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SNW1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNW1 Gene

Orthologs for SNW1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNW1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SNW1 34 35
  • 99.56 (n)
dog
(Canis familiaris)
 Mammalia -- 35
  • 99 (a)
 OneToMany
-- 35
  • 99 (a)
 OneToMany
SNW1 34
  • 94.53 (n)
oppossum
(Monodelphis domestica)
 Mammalia SNW1 35
  • 99 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia SNW1 35
  • 98 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia SNW1 34 35
  • 94.15 (n)
mouse
(Mus musculus)
 Mammalia Snw1 34 16 35
  • 92.23 (n)
rat
(Rattus norvegicus)
 Mammalia Snw1 34
  • 91.36 (n)
chicken
(Gallus gallus)
 Aves SNW1 34 35
  • 83.33 (n)
lizard
(Anolis carolinensis)
 Reptilia SNW1 35
  • 96 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia snw1 34
  • 77.13 (n)
Str.6904 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.28747 34
zebrafish
(Danio rerio)
 Actinopterygii snw1 34 35
  • 76.34 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP004521 34
  • 64.12 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Bx42 36 34 35
  • 60.76 (n)
worm
(Caenorhabditis elegans)
 Secernentea skp-1 34 35
  • 60.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PRP45 35 37
  • 31 (a)
 OneToOne
thale cress
(Arabidopsis thaliana)
 eudicotyledons SKIP 34
  • 57.74 (n)
rice
(Oryza sativa)
 Liliopsida Os02g0759800 34
  • 56.66 (n)
Os.19400 34
barley
(Hordeum vulgare)
 Liliopsida Hv.2879 34
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.2170 35
  • 66 (a)
 OneToOne
bread mold
(Neurospora crassa)
 Ascomycetes NCU03799 34
  • 55.56 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes prp45 34
  • 54.24 (n)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.4259 34
Species where no ortholog for SNW1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNW1 Gene

ENSEMBL:
Gene Tree for SNW1 (if available)
TreeFam:
Gene Tree for SNW1 (if available)

Paralogs for SNW1 Gene

Pseudogenes.org Pseudogenes for SNW1 Gene

genes like me logo Genes that share paralogs with SNW1: view

No data available for Paralogs for SNW1 Gene

Variants for SNW1 Gene

Sequence variations from dbSNP and Humsavar for SNW1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000021833 -- 77,745,881(+) TAGCC(A/G)GGCAT intron-variant
rs1000067780 -- 77,725,085(+) AATTT(A/C)CCTGA intron-variant
rs1000082717 -- 77,751,562(+) AATTG(C/T)TGAGT intron-variant
rs1000275309 -- 77,726,347(+) AGAGA(G/T)AGGGT intron-variant
rs1000323371 -- 77,731,361(+) CCCCA(A/G)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNW1 Gene

Variant ID Type Subtype PubMed ID
esv1469738 CNV insertion 17803354
esv2759998 CNV gain 17122850
esv34940 CNV gain 17911159
esv3551814 CNV deletion 23714750
esv3635010 CNV gain 21293372
esv3635013 CNV loss 21293372
nsv519957 CNV loss 19592680
nsv520021 CNV gain 19592680
nsv521287 CNV gain 19592680

Variation tolerance for SNW1 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNW1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNW1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNW1 Gene

Disorders for SNW1 Gene

Relevant External Links for SNW1

Genetic Association Database (GAD)
SNW1
Human Genome Epidemiology (HuGE) Navigator
SNW1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNW1

No disorders were found for SNW1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNW1 Gene

Publications for SNW1 Gene

  1. A large intrinsically disordered region in SKIP and its disorder- order transition induced by PPIL1 binding revealed by NMR. (PMID: 20007319) Wang X. … Shi Y. (J. Biol. Chem. 2010) 3 4 22 64
  2. The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. (PMID: 20368803) Stegmann C.M. … Wahl M.C. (PLoS ONE 2010) 3 4 22 64
  3. SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation. (PMID: 19818711) Bres V. … Jones K.A. (Mol. Cell 2009) 3 4 22 64
  4. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. (PMID: 16595688) Xu C. … Zhang Q. (J. Biol. Chem. 2006) 3 4 22 64
  5. A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. (PMID: 15905409) Bres V. … Jones K.A. (Genes Dev. 2005) 3 4 22 64

Products for SNW1 Gene

Sources for SNW1 Gene

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