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SNW1 Gene

protein-coding   GIFtS: 66
GCID: GC14M078183

SNW Domain Containing 1

(Previous name: SKI interacting protein)
(Previous symbol: SKIIP)
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Aliases
for SNW1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SNW Domain Containing 11 2     NCOA-622
SKIIP1 2 3 5     PRPF452
SKIP2 3 5     Prp452
SKI Interacting Protein1 2     Homolog Of Drosophila BX422
Nuclear Protein SkiP2 3     Nuclear Receptor Coactivator, 62-KD2
Nuclear Receptor Coactivator NCoA-622 3     SNW Domain-Containing Protein 12
Ski-Interacting Protein2 3     BX425
Bx422     

External Ids:    HGNC: 166961   Entrez Gene: 229382   Ensembl: ENSG000001006037   OMIM: 6030555   UniProtKB: Q135733   

Export aliases for SNW1 gene to outside databases

Previous GC identifers: GC14M075689 GC14M072000 GC14M076173 GC14M077254 GC14M058349


Summaries
for SNW1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNW1 Gene:
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II
promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid
receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can
also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the
expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in
oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SNW1 Gene:
SNW1 (SNW domain containing 1) is a protein-coding gene. Diseases associated with SNW1 include oculopharyngeal muscular dystrophy, and rabies. GO annotations related to this gene include transcription coactivator activity and SMAD binding.

UniProtKB/Swiss-Prot: SNW1_HUMAN, Q13573
Function: Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with
SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression,
and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific
manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional
activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit
transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with
DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD.
Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is
recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of
MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the
specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is
proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP
complex which associates with both the 3'end of the CCND1 gene and its mRNA

Gene Wiki entry for SNW1 Gene


Genomic Views
for SNW1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNW1 gene promoter:
         Pbx1a   AML1a   CUTL1   GATA-1   AREB6   POU2F1   POU2F1a   POU2F1b   POU2F1c   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNW1 promoter sequence
   Search Chromatin IP Primers for SNW1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNW1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q22.1-q22.3

SNW1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNW1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M078183:  view genomic region     (about GC identifiers)

Start:
 78,183,942 bp from pter      End:
 78,227,550 bp from pter
Size:
 43,609 bases      Orientation:
 minus strand

Proteins
for SNW1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SNW1_HUMAN, Q13573 (See protein sequence)
Recommended Name: SNW domain-containing protein 1  
Size: 536 amino acids; 61494 Da
Subunit: Interacts SKI, SMAD2,SMAD3, RBPJ, RB1, PABPN1, MAGEA1, SIRT1, FOXN3, U2AF2, PPIL1, DAXX and ATP1B4.
Interacts with VDR and RXRA; preferentially associates with VDR:RXRA heterodimers. Interacts with NCOR2 and EBV
EBNA2; NCOR2 and EBV EBNA2 compete for interaction with SNW1. Interacts with MAML1. Interacts with NOTCH1 NICD;
the interaction involves multimerized NOTCH1 NICD. Forms a complex with NOTCH1 NICD and MAML1; the association is
dissociated by RBPJ. Identified in the spliceosome C complex. Associates with U4/U6-U5 tri-small nuclear
ribonucleoproteins (U4/U6-U5 tri-snRNPs). Associates with positive transcription elongation factor b (P-TEFb).
Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Interacts with
human papillomavirus type-16 (HPV16) E7 protein
Secondary accessions: A8K8A9 Q13483 Q32N03 Q5D0D6

Explore the universe of human proteins at neXtProt for SNW1: NX_Q13573

Explore proteomics data for SNW1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys193, Lys416
  • Modification sites at PhosphoSitePlus

    • See SNW1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036377.1  
    ENSEMBL proteins: 
     ENSP00000261531   ENSP00000452059   ENSP00000451741   ENSP00000451129   ENSP00000452473  
    Reactome Protein details: Q13573

    SNW1 Human Recombinant Protein Products:

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    Novus Biologicals SNW1 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SNW1

    SNW1 Antibody Products:

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    SNW1 Assay Products:

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    Cloud-Clone Corp. ELISAs for SNW1
    Cloud-Clone Corp. CLIAs for SNW1

    Domains /
    Families
    for SNW1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 2 InterPro protein domains:
     IPR017862 SKI-int_prot_SKIP
     IPR004015 SKI-int_prot_SKIP_SNW-dom

    Graphical View of Domain Structure for InterPro Entry Q13573

    ProtoNet protein and cluster: Q13573

    1 Blocks protein domain: IPB004015 SKIP/SNW domain

    UniProtKB/Swiss-Prot: SNW1_HUMAN, Q13573
    Similarity: Belongs to the SNW family


    SNW1 for domains           About GeneDecksing


    Function
    for SNW1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNW1_HUMAN, Q13573
    Function: Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with
    SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression,
    and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific
    manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional
    activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit
    transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with
    DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD.
    Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is
    recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of
    MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the
    specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is
    proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP
    complex which associates with both the 3'end of the CCND1 gene and its mRNA

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA11514567
    GO:0003714transcription corepressor activity IDA14985122
    GO:0005112Notch binding IPI10713164
    GO:0005515protein binding IPI10713164
    GO:0005525GTP binding ----
         
    SNW1 for ontologies           About GeneDecksing


    Phenotypes:
         14 GenomeRNAi human phenotypes for SNW1:
     Cell division defect  Decreased cell number  Decreased homologous recombina  Decreased influenza A H1N1 (A/ 
     Decreased influenza A/WSN/33 r  Decreased mitotic index  Decreased viability of wild-ty  Downregulation of NF-kappaB pa 
     Downregulation of NF-kappaB pa  G0/1 arrest  Increased Salmonella enterica   Increased gamma-H2AX phosphory 
     Increased number of mitotic ce  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNW1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNW1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNW1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNW1

    miRNA
    Products:            		miRTarBase miRNAs that target SNW1:
    hsa-let-7c-5p (MIRT051793)

    Block miRNA regulation of human, mouse, rat SNW1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SNW1:
    hsa-miR-33a* hsa-miR-4307 hsa-miR-659 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-548n hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SNW1 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for SNW1
    Predesigned siRNA for gene silencing in human, mouse, rat SNW1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SNW1

    Clone
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    OriGene ORF clones in mouse, rat for SNW1
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    GenScript: all cDNA clones in your preferred vector: SNW1 (NM_012245)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNW1

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNW1


    Localization
    for SNW1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNW1_HUMAN, Q13573: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA15194481
    GO:0005730NOT nucleolus IDA--

    SNW1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for SNW1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNW1 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Notch signaling pathway (KEGG)
    		Notch signaling pathway0.84
    		Notch Signaling0.30
    		Delta-Notch Signaling Pathway0.33
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    		Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    		Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    		Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    		Signaling by NOTCH1 in Cancer0.79
    		FBXW7 Mutants and NOTCH1 in Cancer0.79
    		Signaling by NOTCH10.79
    		NOTCH1 Intracellular Domain Regulates Transcription0.68
    3Pre-NOTCH Expression and Processing
    		Pre-NOTCH Expression and Processing0.62
    		Notch-HLH transcription pathway0.00
    		Pre-NOTCH Transcription and Translation0.62
    4Development NOTCH1 mediated pathway for NF KB activity modulation
    		Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    		Development Notch Signaling Pathway0.50
    5Gene Expression
    		Generic Transcription Pathway0.40
    		Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for SNW1
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SNW1
        Notch Signaling

    2 GeneGo (Thomson Reuters) Pathways for SNW1
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway

    2 BioSystems Pathways for SNW1
        TGF-beta Receptor Signaling Pathway
    Delta-Notch Signaling Pathway

    5 Reactome Pathways for SNW1
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Pre-NOTCH Transcription and Translation
    Notch-HLH transcription pathway
    Constitutive Signaling by NOTCH1 PEST Domain Mutants


    4 Kegg Pathways  (Kegg details for SNW1):
        Spliceosome
    Notch signaling pathway
    Epstein-Barr virus infection
    Viral carcinogenesis


    SNW1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SNW1: 
              Notch Signaling Targets in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SNW1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNW1 (Q135731, 2, 3 ENSP000002615314) via UniProtKB, MINT, STRING, and/or I2D (see all 1017)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOR2Q9Y6181, 2, 3, ENSP000003485514EBI-632715,EBI-80830 MINT-7945693 I2D: score=2 STRING: ENSP00000348551
    HDAC2Q927692, 3, ENSP000003813314MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000381331
    HSPA5P110212, 3, ENSP000003241734MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000324173
    NCOR1O753762, 3, ENSP000002687124MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000268712
    PRPF8Q6P2Q92, 3, ENSP000003043504MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000304350
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA14985122
    GO:0000398mRNA splicing, via spliceosome IDA15194481
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9632709
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane ----

    SNW1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNW1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNW1

    2 Novoseek inferred chemical compound relationships for SNW1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d 17.4 1 14985122 (1)
    steroid 12.8 1 12359070 (1)



    SNW1 for compounds           About GeneDecksing



    Transcripts
    for SNW1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for SNW1 gene: 
    NM_012245.2  

    Unigene Cluster for SNW1:

    SNW domain containing 1
    Hs.445498  [show with all ESTs]
    Unigene Representative Sequence: AF045184
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261531(uc001xuf.3 uc010tvm.2) ENST00000554775 ENST00000556428
    ENST00000555761(uc010tvn.1) ENST00000553565 ENST00000554324 ENST00000557663

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate SNW1:
    hsa-miR-33a* hsa-miR-4307 hsa-miR-659 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-548n hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SNW1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SNW1
    Clone
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SNW1
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      QuantiFast Probe-based Assays in human, mouse, rat SNW1

    Additional mRNA sequence: 

    AF045184.1 AK292274.1 AK293619.1 AK302246.1 AK316087.1 BC032377.2 BC040112.2 BC046105.2 
    BC051806.1 BC065286.1 BC105585.1 BC108902.1 BC108903.1 BT020060.1 BT020061.1 CR457433.1 
    U51432.1 

    16 DOTS entries:

    DT.100879259  DT.445417  DT.95308927  DT.100879277  DT.40263026  DT.100879268  DT.121399893  DT.97806586 
    DT.100879265  DT.100879267  DT.100879272  DT.101982632  DT.120787420  DT.92445691  DT.105857  DT.86858181 

    Selected AceView cDNA sequences (see all 357):

    BC040112 AW135425 CB138175 BQ935379 BX427758 BM909512 AF045184 BQ887751 
    BC046105 AU141036 BM666723 BU167929 CB139276 C00049 BI829410 AL556751 
    NM_012245 CD109888 BM479448 BI260987 CR594471 Z39188 BQ058951 AU141828 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SNW1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                                    
    SP2:                                                                                    


    ECgene alternative splicing isoforms for SNW1

    Expression
    for SNW1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNW1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCCCACA
    SNW1 Expression
    About this image


    SNW1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    SNW1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    SNW1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445498
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SNW1: 
              Notch Signaling Targets in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for SNW1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SNW1
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    In Situ
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNW1

    Orthologs
    for SNW1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNW1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Snw11 , 5 SNW domain containing 11, 5 92.23(n)1
    99.25(a)1    		   12 (41.67 cM)5
    663541  NM_025507.21  NP_079783.21 
     874499365 
    chicken
    (Gallus gallus)    		 Aves SNW11 SNW domain containing 1 83.33(n)
    95.71(a)    		   423381  XM_421294.4  XP_421294.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SNW16
    		 SNW domain containing 1
    		 96(a)
    		 1 ↔ 1
    		 1(20483591-20506141)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.287472 Xenopus laevis transcribed sequence with moderate similarity more 76.61(n)    CA985926.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii snw11 SNW domain containing 1 76.34(n)
    84.83(a)    		   321852  NM_001002864.1  NP_001002864.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Bx421 , 3 Bx421 62(a)3
    60.76(n)1
    64.76(a)1    		   8C93
    318401  NM_001272441.11  NP_001259370.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea skp-11 skp-1 60.15(n)
    60.08(a)    		   179598  NM_073549.7  NP_505950.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PRP45(YAL032C)4 Protein required for pre-mRNA splicing; associates more   --   1(84474-83335) 851201  NP_009370.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SKIP1 SKIP 57.74(n)
    53.17(a)    		   844055  NM_106368.4  NP_565151.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.194002 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.11(n)    AK067153.1 


    ENSEMBL Gene Tree for SNW1 (if available)
    TreeFam Gene Tree for SNW1 (if available)

    Paralogs
    for SNW1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNW1 gene

    SNW1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for SNW1
    PGOHUM00000261864 PGOHUM00000261878 PGOHUM00000244767


    Genomic Variants
    for SNW1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNW1 (see all 898)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1388666651,2
    		F--78184485(+) CTGCTA/GTCTGA 2 D syn11Minor allele frequency- G:0.00NA 4552
    rs1769601,2
    		C,F,O,H--78184566(+) AACTGA/CACTGG 2 V syn1 ese322Minor allele frequency- G:0.00EA NA MN NS WA CSA EU 8098
    rs178256201,2
    		C,F,H--78184661(+) ACTACT/GTTGCT 1 -- int126Minor allele frequency- G:0.14NA NS EA CSA WA 2908
    rs1424693381,2
    		C--78184670(+) CTTTCA/CCCAGT 1 -- int10--------
    rs2005781291,2
    		--78184757(+) TCCTTA/GTCCAG 2 D syn10--------
    rs3708557391,2
    		C--78184942(+) AACAT-/TTTACA 1 -- int10--------
    rs1461084961,2
    		--78184956(+) AACCCC/TTGCTA 1 -- int10--------
    rs781606261,2
    		--78184982(+) TTTCAA/GCAATC 1 -- int10--------
    rs1874279991,2
    		--78185141(+) CCACCA/GCCTCC 1 -- int10--------
    rs1498366151,2
    		--78185194(+) GATTAC/TAGGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SNW1 (78183942 - 78227550 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SNW1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1469738CNV Insertion17803354
    nsv519957CNV Loss19592680
    nsv521287CNV Gain19592680
    esv34940CNV Gain17911159
    nsv520021CNV Gain19592680
    essv7944CNV CNV17122850
    dgv643e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNW1
    DNA2.0 Custom Variant and Variant Library Synthesis for SNW1

    Disorders / Diseases
    for SNW1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603055    OMIM disorders: --

    18 diseases for SNW1:    
    About MalaCards
    oculopharyngeal muscular dystrophy    rabies    retinoblastoma    colon adenocarcinoma
    muscular dystrophy    asthma    hiv-1    tonsillitis
    pancreatic cancer    pancreatitis    adenocarcinoma    lung cancer
    cerebritis    thyroiditis    malaria    prostatitis
    neuronitis    endotheliitis


    SNW1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for SNW1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 39.7 2 15194481 (1), 14611687 (1)

    Genetic Association Database (GAD): SNW1
    Human Genome Epidemiology (HuGE) Navigator: SNW1 (3 documents)

    Export disorders for SNW1 gene to outside databases

    Publications
    for SNW1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNW1 gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with SNW1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel coactivator protein, NCoA- 62, involved in vitamin D-mediated transcription. (PubMed id 9632709)1, 2, 3 Baudino T.A.... Macdonald P.N. (J. Biol. Chem. 1998)
    2. The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. (PubMed id 20368803)1, 2, 9 Stegmann C.M.... Wahl M.C. (PLoS ONE 2010)
    3. The human Ski-interacting protein functionally substitutes for the yeast PRP45 gene. (PubMed id 15194481)1, 2, 9 Figueroa J.D. and Hayman M.J. (Biochem. Biophys. Res. Commun. 2004)
    4. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. (PubMed id 16595688)1, 2, 9 Xu C.... Zhang Q. (J. Biol. Chem. 2006)
    5. A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. (PubMed id 15905409)1, 2, 9 Bres V.... Jones K.A. (Genes Dev. 2005)
    6. The product of an oculopharyngeal muscular dystrophy gene, poly(A)- binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression. (PubMed id 11371506)1, 2, 9 Kim Y.-J....Arahata K. (Hum. Mol. Genet. 2001)
    7. The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42. (PubMed id 9569025)1, 2, 9 Dahl R.... Hayman M.J. (Oncogene 1998)
    8. A large intrinsically disordered region in SKIP and its disorder- order transition induced by PPIL1 binding revealed by NMR. (PubMed id 20007319)1, 2, 9 Wang X....Shi Y. (J. Biol. Chem. 2010)
    9. Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300. (PubMed id 14985122)1, 2, 9 Leong G.M.... Gardiner E.M. (Biochem. Biophys. Res. Commun. 2004)
    10. SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation. (PubMed id 19818711)1, 2, 9 Bres V.... Jones K.A. (Mol. Cell 2009)

    External Searches for SNW1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SNW1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22938 HGNC: 16696 AceView: SKIIP Ensembl:ENSG00000100603 euGenes: HUgn22938
    ECgene: SNW1 Kegg: 22938 H-InvDB: SNW1

    Other Databases showing SNW1 gene

    (According to HUGE)
    About This Section

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    Specialized Databases showing SNW1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SNW1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SNW1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SNW1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for SNW1 gene:
    Search GeneIP for patents involving SNW1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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