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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SNW1 Gene

protein-coding GIFtS: 65
GCID: GC14M078183

SNW Domain Containing 1

(Previous name: SKI interacting protein)
(Previous symbol: SKIIP)

Microbiology & Infectious Diseases Congress

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at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
SNW Domain Containing 1¹ ²		Bx42²
SKIIP¹ ² ³		NCOA-62²
SKI Interacting Protein¹ ²		PRPF45²
Nuclear Protein SkiP² ³		Prp45²
Nuclear Receptor Coactivator NCoA-62² ³		Homolog Of Drosophila BX42²
Ski-Interacting Protein² ³		Nuclear Receptor Coactivator, 62-KD²
SKIP² ³		SNW Domain-Containing Protein 1²

External Ids:	HGNC: 16696¹	Entrez Gene: 22938²	Ensembl: ENSG00000100603⁷	OMIM: 603055⁵	UniProtKB: Q13573³

Export aliases for SNW1 gene to outside databases

Previous GC identifers: GC14M075689 GC14M072000 GC14M076173 GC14M077254 GC14M058349

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNW1 Gene:

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II

promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors

to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as

a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific

genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a

region of SKI oncoproteins that is required for transforming activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for SNW1 Gene:

SNW1 (SNW domain containing 1) is a protein-coding gene. Diseases associated with SNW1 include oculopharyngeal muscular dystrophy, and rabies, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Notch signaling pathway. GO annotations related to this gene include transcription coactivator activity and SMAD binding.

UniProtKB/Swiss-Prot: SNW1_HUMAN, Q13573

Function: Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD

proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and

retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner

probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to

multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such

as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a

transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in

transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR

RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter.

Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the

function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May

be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the

CCND1 gene and its mRNA

Gene Wiki entry for SNW1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NT_026437.12 NC_018925.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SNW1 gene promoter:
Pbx1a AML1a CUTL1 GATA-1 AREB6 POU2F1 POU2F1a POU2F1b POU2F1c Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNW1 promoter sequence

Search SABiosciences Chromatin IP Primers for SNW1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNW1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q22.1-q22.3

SNW1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNW1 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M078183: view genomic region (about GC identifiers)

Start:	78,183,942 bp from pter	End:	78,227,550 bp from pter
Size:	43,609 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNW1_HUMAN, Q13573 (See protein sequence)

Recommended Name: SNW domain-containing protein 1

Size: 536 amino acids; 61494 Da

Subunit: Interacts SKI, SMAD2,SMAD3, RBPJ, RB1, PABPN1, MAGEA1, SIRT1, FOXN3, U2AF2, PPIL1, DAXX and ATP1B4. Interacts

with VDR and RXRA; preferentially associates with VDR:RXRA heterodimers. Interacts with NCOR2 and EBV EBNA2; NCOR2 and

EBV EBNA2 compete for interaction with SNW1. Interacts with MAML1. Interacts with NOTCH1 NICD; the interaction

involves multimerized NOTCH1 NICD. Forms a complex with NOTCH1 NICD and MAML1; the association is dissociated by RBPJ.

Identified in the spliceosome C complex. Associates with U4/U6-U5 tri-small nuclear ribonucleoproteins (U4/U6-U5

tri-snRNPs). Associates with positive transcription elongation factor b (P-TEFb). Component of the SNARP complex which

consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Interacts with human papillomavirus type-16 (HPV16) E7

protein

Subcellular location: Nucleus

Secondary accessions: A8K8A9 Q13483 Q32N03 Q5D0D6

Explore the universe of human proteins at neXtProt for SNW1: NX_Q13573

Explore proteomics data for SNW1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q13573

SNW1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_036377.1

ENSEMBL proteins:

ENSP00000261531 ENSP00000452059 ENSP00000451741 ENSP00000451129 ENSP00000452473

Reactome Protein details: Q13573
Human Recombinant Protein Products for SNW1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for SNW1 OriGene Custom MassSpec OriGene Custom Protein Services for SNW1
	GenScript Custom Purified and Recombinant Proteins Services for SNW1
	Novus Biologicals SNW1 Proteins Novus Biologicals SNW1 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SNW1

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000785	chromatin	IEA	--
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005681	spliceosomal complex	IDA	15194481
GO:0005730	NOT nucleolus	IDA	--

SNW1 for ontologies About GeneDecksing

SNW1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for SNW1 OriGene Custom Antibody Services for SNW1
	GenScript Custom Superior Antibodies Services for SNW1
	Novus Biologicals SNW1 Antibodies
	Abcam antibodies for SNW1
	Cloud-Clone Corp. Antibodies for SNW1
	ThermoFisher Antibody for SNW1
	LSBio Antibodies in human, mouse, rat for SNW1

Assay Products for SNW1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SNW1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SNW1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SNW1 Cloud-Clone Corp. CLIAs for SNW1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR017862 SKI-int_prot_SKIP

IPR004015 SKI-int_prot_SKIP_SNW-dom

Graphical View of Domain Structure for InterPro Entry Q13573

ProtoNet protein and cluster: Q13573

1 Blocks protein domain: IPB004015 SKIP/SNW domain

UniProtKB/Swiss-Prot: SNW1_HUMAN, Q13573

Similarity: Belongs to the SNW family

SNW1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SNW1_HUMAN, Q13573