Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SNW1 Gene

Aliases for SNW1 Gene

  • SNW Domain Containing 1 2 3
  • SKIIP 3 4 6
  • SKIP 3 4 6
  • Nuclear Receptor Coactivator NCoA-62 3 4
  • SKI Interacting Protein 2 3
  • Nuclear Protein SkiP 3 4
  • Bx42 3 6
  • Nuclear Receptor Coactivator, 62-KD 3
  • SNW Domain-Containing Protein 1 3
  • Homolog Of Drosophila BX42 3
  • SKI-Interacting Protein 3
  • Ski-Interacting Protein 4
  • NCOA-62 3
  • PRPF45 3
  • Prp45 3

External Ids for SNW1 Gene

Previous Symbols for SNW1 Gene

  • SKIIP

Summaries for SNW1 Gene

Entrez Gene Summary for SNW1 Gene

  • This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNW1 Gene

SNW1 (SNW Domain Containing 1) is a Protein Coding gene. Diseases associated with SNW1 include oculopharyngeal muscular dystrophy. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include transcription coactivator activity and SMAD binding.

UniProtKB/Swiss-Prot for SNW1 Gene

  • Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA.

Gene Wiki entry for SNW1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNW1 Gene

Genomics for SNW1 Gene

Genomic Location for SNW1 Gene

Start:
77,717,599 bp from pter
End:
77,761,207 bp from pter
Size:
43,609 bases
Orientation:
Minus strand

Genomic View for SNW1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNW1 Gene

Regulatory Elements for SNW1 Gene

Proteins for SNW1 Gene

  • Protein details for SNW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13573-SNW1_HUMAN
    Recommended name:
    SNW domain-containing protein 1
    Protein Accession:
    Q13573
    Secondary Accessions:
    • A8K8A9
    • Q13483
    • Q32N03
    • Q5D0D6

    Protein attributes for SNW1 Gene

    Size:
    536 amino acids
    Molecular mass:
    61494 Da
    Quaternary structure:
    • Interacts SKI, SMAD2,SMAD3, RBPJ, RB1, PABPN1, MAGEA1, SIRT1, FOXN3, U2AF2, PPIL1, DAXX and ATP1B4. Interacts with VDR and RXRA; preferentially associates with VDR:RXRA heterodimers. Interacts with NCOR2 and EBV EBNA2; NCOR2 and EBV EBNA2 compete for interaction with SNW1. Interacts with MAML1. Interacts with NOTCH1 NICD; the interaction involves multimerized NOTCH1 NICD. Forms a complex with NOTCH1 NICD and MAML1; the association is dissociated by RBPJ. Identified in the spliceosome C complex. Associates with U4/U6-U5 tri-small nuclear ribonucleoproteins (U4/U6-U5 tri-snRNPs). Associates with positive transcription elongation factor b (P-TEFb). Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Interacts with human papillomavirus type-16 (HPV16) E7 protein.

neXtProt entry for SNW1 Gene

Proteomics data for SNW1 Gene at MOPED

Post-translational modifications for SNW1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys193 and Lys416

Other Protein References for SNW1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SNW1 Gene

Domains for SNW1 Gene

Protein Domains for SNW1 Gene

UniProtKB/Swiss-Prot:

SNW1_HUMAN
Family:
  • Belongs to the SNW family.:
    • Q13573
genes like me logo Genes that share domains with SNW1: view

No data available for Gene Families for SNW1 Gene

Function for SNW1 Gene

Molecular function for SNW1 Gene

UniProtKB/Swiss-Prot Function: Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA.

Gene Ontology (GO) - Molecular Function for SNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 11514567
GO:0003714 transcription corepressor activity IDA 14985122
GO:0005112 Notch binding IPI 10713164
GO:0005515 protein binding IPI 10713164
GO:0005525 GTP binding --
genes like me logo Genes that share ontologies with SNW1: view
genes like me logo Genes that share phenotypes with SNW1: view

miRNA for SNW1 Gene

miRTarBase miRNAs that target SNW1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNW1 Gene

Localization for SNW1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNW1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNW1 Gene COMPARTMENTS Subcellular localization image for SNW1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA 15878163
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 15194481
GO:0008024 colocalizes_with positive transcription elongation factor complex b IDA 15905409
genes like me logo Genes that share ontologies with SNW1: view

Pathways for SNW1 Gene

genes like me logo Genes that share pathways with SNW1: view

Gene Ontology (GO) - Biological Process for SNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14985122
GO:0000398 mRNA splicing, via spliceosome IDA 15194481
GO:0006351 transcription, DNA-templated TAS --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9632709
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SNW1: view

Compounds for SNW1 Gene

(2) Novoseek inferred chemical compound relationships for SNW1 Gene

Compound -log(P) Hits PubMed IDs
vitamin d 17.4 1
steroid 12.8 1
genes like me logo Genes that share compounds with SNW1: view

Transcripts for SNW1 Gene

Unigene Clusters for SNW1 Gene

SNW domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNW1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1:
SP2:

Relevant External Links for SNW1 Gene

GeneLoc Exon Structure for
SNW1
ECgene alternative splicing isoforms for
SNW1

Expression for SNW1 Gene

mRNA expression in normal human tissues for SNW1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNW1 Gene

SOURCE GeneReport for Unigene cluster for SNW1 Gene Hs.445498

genes like me logo Genes that share expressions with SNW1: view

Orthologs for SNW1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNW1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNW1 36
  • 99.56 (n)
  • 100 (a)
SNW1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNW1 36
  • 94.15 (n)
  • 99.63 (a)
SNW1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 99 (a)
OneToMany
-- 37
  • 99 (a)
OneToMany
SNW1 36
  • 94.53 (n)
  • 99.63 (a)
mouse
(Mus musculus)
Mammalia Snw1 36
  • 92.23 (n)
  • 99.25 (a)
Snw1 16
Snw1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNW1 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNW1 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snw1 36
  • 91.36 (n)
  • 99.07 (a)
chicken
(Gallus gallus)
Aves SNW1 36
  • 83.33 (n)
  • 95.71 (a)
SNW1 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNW1 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.28747 36
tropical clawed frog
(Silurana tropicalis)
Amphibia snw1 36
  • 77.13 (n)
  • 88.97 (a)
Str.6904 36
zebrafish
(Danio rerio)
Actinopterygii snw1 36
  • 76.34 (n)
  • 84.83 (a)
snw1 37
  • 87 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004521 36
  • 64.12 (n)
  • 68.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bx42 36
  • 60.76 (n)
  • 64.76 (a)
Bx42 37
  • 60 (a)
OneToOne
Bx42 38
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea skp-1 36
  • 60.15 (n)
  • 60.08 (a)
skp-1 37
  • 56 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP45 37
  • 31 (a)
OneToOne
PRP45 39
thale cress
(Arabidopsis thaliana)
eudicotyledons SKIP 36
  • 57.74 (n)
  • 53.17 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2879 36
rice
(Oryza sativa)
Liliopsida Os.19400 36
Os02g0759800 36
  • 56.66 (n)
  • 58.14 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03799 36
  • 55.56 (n)
  • 52.53 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp45 36
  • 54.24 (n)
  • 50.51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4259 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2170 37
  • 66 (a)
OneToOne
Species with no ortholog for SNW1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNW1 Gene

ENSEMBL:
Gene Tree for SNW1 (if available)
TreeFam:
Gene Tree for SNW1 (if available)

Paralogs for SNW1 Gene

Pseudogenes.org Pseudogenes for SNW1 Gene

genes like me logo Genes that share paralogs with SNW1: view

No data available for Paralogs for SNW1 Gene

Variants for SNW1 Gene

Sequence variations from dbSNP and Humsavar for SNW1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs114763 -- 77,731,022(+) CTTCT(C/T)TCCCT synonymous-codon, reference
rs176960 -- 77,718,223(+) AACTG(A/C)ACTGG reference, synonymous-codon, utr-variant-3-prime, missense
rs176961 -- 77,719,085(+) atttt(C/T)tgtag intron-variant
rs176962 -- 77,719,167(+) aagtg(C/T)tagga intron-variant
rs176963 -- 77,719,946(+) GCGCA(C/T)GCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNW1 Gene

Variant ID Type Subtype PubMed ID
dgv643e1 CNV Complex 17122850
essv7944 CNV CNV 17122850
esv34940 CNV Gain 17911159
nsv521287 CNV Gain 19592680
nsv520021 CNV Gain 19592680
nsv519957 CNV Loss 19592680
esv1469738 CNV Insertion 17803354

Relevant External Links for SNW1 Gene

HapMap Linkage Disequilibrium report
SNW1

Disorders for SNW1 Gene

(1) Novoseek inferred disease relationships for SNW1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 39.7 2

Relevant External Links for SNW1

Genetic Association Database (GAD)
SNW1
Human Genome Epidemiology (HuGE) Navigator
SNW1
genes like me logo Genes that share disorders with SNW1: view

No data available for UniProtKB/Swiss-Prot for SNW1 Gene

Publications for SNW1 Gene

  1. Ternary complexes and cooperative interplay between NCoA-62/Ski- interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription. (PMID: 11514567) Zhang C. … MacDonald P.N. (J. Biol. Chem. 2001) 3 4 23
  2. The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42. (PMID: 9569025) Dahl R. … Hayman M.J. (Oncogene 1998) 3 4 23
  3. The product of an oculopharyngeal muscular dystrophy gene, poly(A)- binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression. (PMID: 11371506) Kim Y.-J. … Arahata K. (Hum. Mol. Genet. 2001) 3 4 23
  4. Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300. (PMID: 14985122) Leong G.M. … Gardiner E.M. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  5. CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. (PMID: 16102918) Scott K.L. … Plon S.E. (Gene 2005) 3 4 23

Products for SNW1 Gene

Sources for SNW1 Gene

Back to Top

Content