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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNW1 Gene

protein-coding   GIFtS: 65
GCID: GC14M078183

SNW Domain Containing 1

(Previous name: SKI interacting protein)
(Previous symbol: SKIIP)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SNW Domain Containing 11 2     Bx422
SKIIP1 2 3     NCOA-622
SKI Interacting Protein1 2     PRPF452
Nuclear Protein SkiP2 3     Prp452
Nuclear Receptor Coactivator NCoA-622 3     Homolog Of Drosophila BX422
Ski-Interacting Protein2 3     Nuclear Receptor Coactivator, 62-KD2
SKIP2 3     SNW Domain-Containing Protein 12

External Ids:    HGNC: 166961   Entrez Gene: 229382   Ensembl: ENSG000001006037   OMIM: 6030555   UniProtKB: Q135733   

Export aliases for SNW1 gene to outside databases

Previous GC identifers: GC14M075689 GC14M072000 GC14M076173 GC14M077254 GC14M058349


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNW1 Gene:
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II
promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid
receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can
also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the
expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in
oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SNW1 Gene: 
SNW1 (SNW domain containing 1) is a protein-coding gene. Diseases associated with SNW1 include oculopharyngeal muscular dystrophy, and rabies, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Notch signaling pathway. GO annotations related to this gene include transcription coactivator activity and SMAD binding.

UniProtKB/Swiss-Prot: SNW1_HUMAN, Q13573
Function: Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with
SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression,
and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific
manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional
activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit
transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with
DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD.
Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is
recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of
MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the
specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is
proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP
complex which associates with both the 3'end of the CCND1 gene and its mRNA

Gene Wiki entry for SNW1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNW1 gene promoter:
         Pbx1a   AML1a   CUTL1   GATA-1   AREB6   POU2F1   POU2F1a   POU2F1b   POU2F1c   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNW1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNW1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNW1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q22.1-q22.3

SNW1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNW1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M078183:  view genomic region     (about GC identifiers)

Start:
78,183,942 bp from pter      End:
78,227,550 bp from pter
Size:
43,609 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNW1_HUMAN, Q13573 (See protein sequence)
Recommended Name: SNW domain-containing protein 1  
Size: 536 amino acids; 61494 Da
Subunit: Interacts SKI, SMAD2,SMAD3, RBPJ, RB1, PABPN1, MAGEA1, SIRT1, FOXN3, U2AF2, PPIL1, DAXX and ATP1B4.
Interacts with VDR and RXRA; preferentially associates with VDR:RXRA heterodimers. Interacts with NCOR2 and EBV
EBNA2; NCOR2 and EBV EBNA2 compete for interaction with SNW1. Interacts with MAML1. Interacts with NOTCH1 NICD;
the interaction involves multimerized NOTCH1 NICD. Forms a complex with NOTCH1 NICD and MAML1; the association is
dissociated by RBPJ. Identified in the spliceosome C complex. Associates with U4/U6-U5 tri-small nuclear
ribonucleoproteins (U4/U6-U5 tri-snRNPs). Associates with positive transcription elongation factor b (P-TEFb).
Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Interacts with
human papillomavirus type-16 (HPV16) E7 protein
Subcellular location: Nucleus
Secondary accessions: A8K8A9 Q13483 Q32N03 Q5D0D6

Explore the universe of human proteins at neXtProt for SNW1: NX_Q13573

Explore proteomics data for SNW1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13573

  • SNW1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNW1 Protein Expression
    REFSEQ proteins: NP_036377.1  
    ENSEMBL proteins: 
     ENSP00000261531   ENSP00000452059   ENSP00000451741   ENSP00000451129   ENSP00000452473  
    Reactome Protein details: Q13573
    Human Recombinant Protein Products for SNW1: 
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    Novus Biologicals SNW1 Proteins
    Novus Biologicals SNW1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNW1 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA15194481
    GO:0005730NOT nucleolus IDA--

    SNW1 for ontologies           About GeneDecksing



    SNW1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR017862 SKI-int_prot_SKIP
     IPR004015 SKI-int_prot_SKIP_SNW-dom

    Graphical View of Domain Structure for InterPro Entry Q13573

    ProtoNet protein and cluster: Q13573

    1 Blocks protein domain: IPB004015 SKIP/SNW domain

    UniProtKB/Swiss-Prot: SNW1_HUMAN, Q13573
    Similarity: Belongs to the SNW family


    SNW1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNW1_HUMAN, Q13573
    Function: Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with
    SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression,
    and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific
    manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional
    activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit
    transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with
    DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD.
    Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is
    recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of
    MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the
    specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is
    proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP
    complex which associates with both the 3'end of the CCND1 gene and its mRNA

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA11514567
    GO:0003714transcription corepressor activity IDA14985122
    GO:0005112Notch binding IPI10713164
    GO:0005515protein binding IPI10713164
    GO:0005525GTP binding ----
         
    SNW1 for ontologies           About GeneDecksing


    Phenotypes:
         14 GenomeRNAi human phenotypes for SNW1:
     Cell division defect  Decreased cell number  Decreased homologous recombina  Decreased influenza A H1N1 (A/ 
     Decreased influenza A/WSN/33 r  Decreased mitotic index  Decreased viability of wild-ty  Downregulation of NF-kappaB pa 
     Downregulation of NF-kappaB pa  G0/1 arrest  Increased Salmonella enterica   Increased gamma-H2AX phosphory 
     Increased number of mitotic ce  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNW1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SNW1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNW1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNW1 

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SNW1:
    hsa-miR-33a* hsa-miR-4307 hsa-miR-659 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-548n hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidSNW1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of SNW1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNW1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SNW1 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.89
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.89
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH10.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.74
    2Notch signaling pathway
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    3Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Development Notch Signaling Pathway0.54
    4Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    5NOTCH2 intracellular domain regulates transcription
    Notch-HLH transcription pathway0.32
    NICD traffics to nucleus0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for SNW1
        Development Notch Signaling Pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation

    1 R&D Systems Pathway for SNW1
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SNW1
        Notch Signaling

    2 GeneGo (Thomson Reuters) Pathways for SNW1
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway

    2 BioSystems Pathways for SNW1
        TGF-beta Receptor Signaling Pathway
    Delta-Notch Signaling Pathway

    5/17        Reactome Pathways for SNW1 (see all 17)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    FBXW7 Mutants and NOTCH1 in Cancer
    Notch-HLH transcription pathway
    Signaling by NOTCH1 HD Domain Mutants in Cancer


    4         Kegg Pathways  (Kegg details for SNW1):
        Spliceosome
    Notch signaling pathway
    Epstein-Barr virus infection
    Viral carcinogenesis


    SNW1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNW1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/930 Interacting proteins for SNW1 (Q135731, 2, 3 ENSP000002615314) via UniProtKB, MINT, STRING, and/or I2D (see all 930)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOR2Q9Y6181, 2, 3, ENSP000003485514EBI-632715,EBI-80830 MINT-7945693 I2D: score=2 STRING: ENSP00000348551
    HDAC2Q927692, 3, ENSP000003813314MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000381331
    HSPA5P110212, 3, ENSP000003241734MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000324173
    NCOR1O753762, 3, ENSP000002687124MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000268712
    PRPF8Q6P2Q92, 3, ENSP000003043504MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000304350
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA14985122
    GO:0000398mRNA splicing, via spliceosome IDA15194481
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9632709
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane ----

    SNW1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNW1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNW1

    2 Novoseek inferred chemical compound relationships for SNW1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d 17.4 1 14985122 (1)
    steroid 12.8 1 12359070 (1)

    Search CenterWatch for drugs/clinical trials and news about SNW1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNW1 gene: 
    NM_012245.2  

    Unigene Cluster for SNW1:

    SNW domain containing 1
    Hs.445498  [show with all ESTs]
    Unigene Representative Sequence: AF045184
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261531(uc001xuf.3 uc010tvm.2) ENST00000554775 ENST00000556428
    ENST00000555761(uc010tvn.1) ENST00000553565 ENST00000554324 ENST00000557663

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNW1

    Additional mRNA sequence: 

    AF045184.1 AK292274.1 AK293619.1 AK302246.1 AK316087.1 BC032377.2 BC040112.2 BC046105.2 
    BC051806.1 BC065286.1 BC105585.1 BC108902.1 BC108903.1 BT020060.1 BT020061.1 CR457433.1 
    U51432.1 

    16 DOTS entries:

    DT.100879259  DT.445417  DT.95308927  DT.100879277  DT.40263026  DT.100879268  DT.121399893  DT.97806586 
    DT.100879265  DT.100879267  DT.100879272  DT.101982632  DT.120787420  DT.92445691  DT.105857  DT.86858181 

    24/357 AceView cDNA sequences (see all 357):

    CB990082 BQ957415 AL560179 BM694524 AU141934 BX459523 BX402926 AW338944 
    BP335446 AA022934 BM679427 BQ068956 BI494705 BQ636821 BM471762 BM785806 
    F07556 AW135425 AA195137 AU141036 CD109888 AA299686 BM666723 BM562642 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SNW1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                                    
    SP2:                                                                                    


    ECgene alternative splicing isoforms for SNW1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNW1 expression in normal human tissues (normalized intensities)      SNW1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCCCACA
    SNW1 Expression
    About this image


    SNW1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/44 selected tissues (see all 44) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Cerebral Cortex
             brain/midbrain   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See SNW1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNW1

    SOURCE GeneReport for Unigene cluster: Hs.445498
        SABiosciences Expression via Pathway-Focused PCR Arrays including SNW1: 
              Notch Signaling Targets in human mouse rat
              Notch Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNW1 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snw11 , 5 SNW domain containing 11, 5 92.23(n)1
    99.25(a)1
      12 (41.67 cM)5
    663541  NM_025507.21  NP_079783.21 
     874499365 
    chicken
    (Gallus gallus)
    Aves SNW11 SNW domain containing 1 83.33(n)
    95.71(a)
      423381  XM_421294.3  XP_421294.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNW16
    SNW domain containing 1
    96(a)
    1 ↔ 1
    1(20483591-20506141)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.287472 Xenopus laevis transcribed sequence with moderate similarity more 76.61(n)    CA985926.1 
    zebrafish
    (Danio rerio)
    Actinopterygii snw11 SNW domain containing 1 76.34(n)
    84.83(a)
      321852  NM_001002864.1  NP_001002864.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bx421 , 3 Bx421 62(a)3
    59.94(n)1
    62.83(a)1
      8C93
    318401  NM_078538.31  NP_511093.21 
    worm
    (Caenorhabditis elegans)
    Secernentea skp-11 Protein SKP-1 58.85(n)
    58.27(a)
      179598  NM_073549.6  NP_505950.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP45(YAL032C)4 Protein required for pre-mRNA splicing; associates more   --   1(84474-83335) 851201  NP_009370.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SKIP1 chromatin protein family 57.77(n)
    52.55(a)
      844055  NM_001036214.2  NP_001031291.1 
    rice
    (Oryza sativa)
    Liliopsida Os.194002 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.11(n)    AK067153.1 


    ENSEMBL Gene Tree for SNW1 (if available)
    TreeFam Gene Tree for SNW1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNW1 gene

    SNW1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for SNW1
    PGOHUM00000261864 PGOHUM00000261878 PGOHUM00000244767


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/898 SNPs in SNW1 are shown (see all 898)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388666651,2
    F--78184485(+) CTGCTA/GTCTGA 2 D syn11Minor allele frequency- G:0.00NA 4552
    rs1769601,2
    C,F,O,H--78184566(+) AACTGA/CACTGG 2 V syn1 ese322Minor allele frequency- G:0.00EA NA MN NS WA CSA EU 8098
    rs178256201,2
    C,F,H--78184661(+) ACTACT/GTTGCT 1 -- int126Minor allele frequency- G:0.14NA NS EA CSA WA 2908
    rs1424693381,2
    C--78184670(+) CTTTCA/CCCAGT 1 -- int10--------
    rs2005781291,2
    --78184757(+) TCCTTA/GTCCAG 2 D syn10--------
    rs3708557391,2
    C--78184942(+) AACAT-/TTTACA 1 -- int10--------
    rs1461084961,2
    --78184956(+) AACCCC/TTGCTA 1 -- int10--------
    rs781606261,2
    --78184982(+) TTTCAA/GCAATC 1 -- int10--------
    rs1874279991,2
    --78185141(+) CCACCA/GCCTCC 1 -- int10--------
    rs1498366151,2
    --78185194(+) GATTAC/TAGGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SNW1 (78183942 - 78227550 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SNW1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1469738CNV Insertion17803354
    nsv519957CNV Loss19592680
    nsv521287CNV Gain19592680
    esv34940CNV Gain17911159
    nsv520021CNV Gain19592680
    essv7944CNV CNV17122850
    dgv643e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603055    OMIM disorders: --

    11 diseases for SNW1:    About MalaCards
    oculopharyngeal muscular dystrophy    rabies    retinoblastoma    muscular dystrophy
    colon adenocarcinoma    asthma    pancreatic cancer    pancreatitis
    adenocarcinoma    lung cancer    neuronitis


    SNW1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SNW1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 39.7 2 15194481 (1), 14611687 (1)

    Genetic Association Database (GAD): SNW1
    Human Genome Epidemiology (HuGE) Navigator: SNW1 (3 documents)

    Export disorders for SNW1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNW1 gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with SNW1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel coactivator protein, NCoA- 62, involved in vitamin D-mediated transcription. (PubMed id 9632709)1, 2, 3 Baudino T.A.... Macdonald P.N. (1998)
    2. The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. (PubMed id 20368803)1, 2, 9 Stegmann C.M....Wahl M.C. (2010)
    3. The human Ski-interacting protein functionally substitutes for the yeast PRP45 gene. (PubMed id 15194481)1, 2, 9 Figueroa J.D. and Hayman M.J. (2004)
    4. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. (PubMed id 16595688)1, 2, 9 Xu C.... Zhang Q. (2006)
    5. A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. (PubMed id 15905409)1, 2, 9 Bres V....Jones K.A. (2005)
    6. The product of an oculopharyngeal muscular dystrophy gene, poly(A)- binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression. (PubMed id 11371506)1, 2, 9 Kim Y.-J....Arahata K. (2001)
    7. The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42. (PubMed id 9569025)1, 2, 9 Dahl R.... Hayman M.J. (1998)
    8. A large intrinsically disordered region in SKIP and i ts disorder-order transition induced by PPIL1 binding revealed by NMR. (PubMed id 20007319)1, 2, 9 Wang X....Shi Y. (2010)
    9. Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300. (PubMed id 14985122)1, 2, 9 Leong G.M....Gardiner E.M. (2004)
    10. SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation. (PubMed id 19818711)1, 2, 9 BrA"s V....Jones K.A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22938 HGNC: 16696 AceView: SKIIP Ensembl:ENSG00000100603 euGenes: HUgn22938
    ECgene: SNW1 Kegg: 22938 H-InvDB: SNW1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNW1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SNW1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNW1 gene:
    Search GeneIP for patents involving SNW1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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