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Aliases for SNURF Gene

Aliases for SNURF Gene

  • SNRPN Upstream Reading Frame 2 3

External Ids for SNURF Gene

Summaries for SNURF Gene

Entrez Gene Summary for SNURF Gene

  • This gene encodes a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5' UTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNURF Gene

SNURF (SNRPN Upstream Reading Frame) is a Protein Coding gene. Diseases associated with SNURF include albrights hereditary osteodystrophy and prader-willi syndrome. Among its related pathways are Coregulation of Androgen receptor activity and mRNA Splicing - Major Pathway.

Gene Wiki entry for SNURF Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNURF Gene

Genomics for SNURF Gene

Genomic Location for SNURF Gene

Start:
24,954,923 bp from pter
End:
24,978,582 bp from pter
Size:
23,660 bases
Orientation:
Plus strand

Genomic View for SNURF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNURF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNURF Gene

Regulatory Elements for SNURF Gene

Proteins for SNURF Gene

  • Protein details for SNURF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y675-SNURF_HUMAN
    Recommended name:
    SNRPN upstream reading frame protein
    Protein Accession:
    Q9Y675
    Secondary Accessions:
    • A6NCW2

    Protein attributes for SNURF Gene

    Size:
    71 amino acids
    Molecular mass:
    8412 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF. In addition to the primary 1.6-kb bicistronic SNURF-SNRPN transcript, SNURF-only transcript is also detected

neXtProt entry for SNURF Gene

Proteomics data for SNURF Gene at MOPED

Post-translational modifications for SNURF Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys26

Other Protein References for SNURF Gene

No data available for DME Specific Peptides for SNURF Gene

Domains for SNURF Gene

Protein Domains for SNURF Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SNURF_HUMAN
Family:
  • Belongs to the SNURF family.:
    • Q9Y675
genes like me logo Genes that share domains with SNURF: view

No data available for Gene Families for SNURF Gene

Function for SNURF Gene

Molecular function for SNURF Gene

GENATLAS Biochemistry: SNRPN upstream reading frame,expressed along and conjointly with SNRPN in a bicistronic transcript,missing in Prader Willi syndrome,paternally expressed,maternally imprinted,associated with a nuclear matrix attachment (MAR) sequence

Gene Ontology (GO) - Molecular Function for SNURF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SNURF: view

miRNA for SNURF Gene

miRTarBase miRNAs that target SNURF

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNURF Gene

Localization for SNURF Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNURF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNURF Gene COMPARTMENTS Subcellular localization image for SNURF gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SNURF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10318933
genes like me logo Genes that share ontologies with SNURF: view

Pathways for SNURF Gene

genes like me logo Genes that share pathways with SNURF: view

Pathways by source for SNURF Gene

Interacting Proteins for SNURF Gene

Gene Ontology (GO) - Biological Process for SNURF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SNURF: view

Transcripts for SNURF Gene

mRNA/cDNA for SNURF Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SNURF Gene

No ASD Table

Relevant External Links for SNURF Gene

GeneLoc Exon Structure for
SNURF
ECgene alternative splicing isoforms for
SNURF

Expression for SNURF Gene

mRNA expression in normal human tissues for SNURF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNURF Gene

This gene is overexpressed in Muscle - Skeletal (4.4).

mRNA Expression by UniProt/SwissProt for SNURF Gene

Q9Y675-SNURF_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle and lymphoblasts (at protein level). Expressed in brain, pancreas, heart, liver, lung, kidney and skeletal muscle.
genes like me logo Genes that share expressions with SNURF: view

Orthologs for SNURF Gene

This gene was present in the common ancestor of mammals.

Orthologs for SNURF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100612044 36
  • 86.67 (n)
  • 77.14 (a)
SNURF 37
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SNURF 36
  • 92.49 (n)
  • 92.96 (a)
mouse
(Mus musculus)
Mammalia Snurf 36
  • 89.67 (n)
  • 97.18 (a)
Snurf 16
Snurf 37
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Snurf 36
  • 90.14 (n)
  • 94.37 (a)
Species with no ortholog for SNURF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNURF Gene

ENSEMBL:
Gene Tree for SNURF (if available)
TreeFam:
Gene Tree for SNURF (if available)

Paralogs for SNURF Gene

Selected SIMAP similar genes for SNURF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNURF: view

No data available for Paralogs for SNURF Gene

Variants for SNURF Gene

Relevant External Links for SNURF Gene

HapMap Linkage Disequilibrium report
SNURF
Human Gene Mutation Database (HGMD)
SNURF

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for SNURF Gene

Disorders for SNURF Gene

(2) University of Copenhagen DISEASES for SNURF Gene

(1) Novoseek inferred disease relationships for SNURF Gene

Disease -log(P) Hits PubMed IDs
prader-willi syndrome 81.1 1
genes like me logo Genes that share disorders with SNURF: view

No data available for UniProtKB/Swiss-Prot for SNURF Gene

Publications for SNURF Gene

  1. An imprinted, mammalian bicistronic transcript encodes two independent proteins. (PMID: 10318933) Gray T.A. … Nicholls R.D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  2. Characterization of cis- and trans-acting elements in the imprinted human SNURF-SNRPN locus. (PMID: 16116039) Rodriguez-Jato S. … Yang T.P. (Nucleic Acids Res. 2005) 3 23
  3. Analysis of candidate imprinted genes in PWS subjects with atypical genetics: a possible inactivating mutation in the SNURF/SNRPN minimal promoter. (PMID: 17262171) Maina E.N. … Holland A. (J. Hum. Genet. 2007) 23
  4. A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'. (PMID: 2522186) Schmauss C. … Lerner M.R. (Nucleic Acids Res. 1989) 3
  5. Primary structure of a human small nuclear ribonucleoprotein polypeptide as deduced by cDNA analysis. (PMID: 2522449) Rokeach L.A. … Hoch S.O. (J. Biol. Chem. 1989) 3

Products for SNURF Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SNURF
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for SNURF
  • Block miRNA regulation of SNURF using miScript Target Protectors

Sources for SNURF Gene

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