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Aliases for SNUPN Gene

Aliases for SNUPN Gene

  • Snurportin 1 2 3
  • RNA, U Transporter 1 2 3
  • RNA U Transporter 1 3 4
  • RNUT1 3 4
  • Snurportin-1 3
  • Snurportin1 3
  • KPNBL 3
  • SPN1 4

External Ids for SNUPN Gene

Previous Symbols for SNUPN Gene

  • RNUT1

Summaries for SNUPN Gene

Entrez Gene Summary for SNUPN Gene

  • The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNUPN Gene

SNUPN (Snurportin 1) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include protein transporter activity and RNA cap binding.

UniProtKB/Swiss-Prot for SNUPN Gene

  • Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.

Gene Wiki entry for SNUPN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNUPN Gene

Genomics for SNUPN Gene

Genomic Location for SNUPN Gene

Start:
75,598,083 bp from pter
End:
75,626,469 bp from pter
Size:
28,387 bases
Orientation:
Minus strand

Genomic View for SNUPN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNUPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNUPN Gene

Regulatory Elements for SNUPN Gene

Proteins for SNUPN Gene

  • Protein details for SNUPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95149-SPN1_HUMAN
    Recommended name:
    Snurportin-1
    Protein Accession:
    O95149
    Secondary Accessions:
    • A6NE34
    • A8K0B0
    • D3DW76

    Protein attributes for SNUPN Gene

    Size:
    360 amino acids
    Molecular mass:
    41143 Da
    Quaternary structure:
    • Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with DDX20, IPO7, KPNB1, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive.

    Three dimensional structures from OCA and Proteopedia for SNUPN Gene

neXtProt entry for SNUPN Gene

Proteomics data for SNUPN Gene at MOPED

Post-translational modifications for SNUPN Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys144 and Lys228

No data available for DME Specific Peptides for SNUPN Gene

Domains for SNUPN Gene

Protein Domains for SNUPN Gene

UniProtKB/Swiss-Prot:

SPN1_HUMAN
Domain:
  • Contains 1 IBB domain.:
    • O95149
Family:
  • Belongs to the snurportin family.:
    • O95149
genes like me logo Genes that share domains with SNUPN: view

No data available for Gene Families for SNUPN Gene

Function for SNUPN Gene

Molecular function for SNUPN Gene

UniProtKB/Swiss-Prot Function: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.

Gene Ontology (GO) - Molecular Function for SNUPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding TAS 9670026
GO:0005515 protein binding --
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with SNUPN: view

Phenotypes for SNUPN Gene

genes like me logo Genes that share phenotypes with SNUPN: view

miRNA for SNUPN Gene

miRTarBase miRNAs that target SNUPN

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNUPN Gene

Localization for SNUPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNUPN Gene

Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta. It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNUPN Gene COMPARTMENTS Subcellular localization image for SNUPN gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for SNUPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005643 nuclear pore TAS 9670026
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SNUPN: view

Pathways for SNUPN Gene

genes like me logo Genes that share pathways with SNUPN: view

Pathways by source for SNUPN Gene

3 Reactome pathways for SNUPN Gene
1 KEGG pathway for SNUPN Gene

Gene Ontology (GO) - Biological Process for SNUPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0006606 protein import into nucleus IEA --
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
GO:0034660 ncRNA metabolic process TAS --
genes like me logo Genes that share ontologies with SNUPN: view

Transcripts for SNUPN Gene

Unigene Clusters for SNUPN Gene

Snurportin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNUPN Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - -
SP2: -
SP3: - - -
SP4:
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: -
SP9:

Relevant External Links for SNUPN Gene

GeneLoc Exon Structure for
SNUPN
ECgene alternative splicing isoforms for
SNUPN

Expression for SNUPN Gene

mRNA expression in normal human tissues for SNUPN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SNUPN Gene

SOURCE GeneReport for Unigene cluster for SNUPN Gene Hs.21577

genes like me logo Genes that share expressions with SNUPN: view

Orthologs for SNUPN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNUPN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNUPN 36
  • 99.34 (n)
  • 100 (a)
SNUPN 37
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNUPN 36
  • 89.91 (n)
  • 89.17 (a)
SNUPN 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNUPN 36
  • 90.17 (n)
  • 90.73 (a)
SNUPN 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snupn 36
  • 89.89 (n)
  • 93.26 (a)
Snupn 16
Snupn 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNUPN 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 72 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Snupn 36
  • 89.55 (n)
  • 93.45 (a)
chicken
(Gallus gallus)
Aves SNUPN 36
  • 70.57 (n)
  • 69.92 (a)
SNUPN 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNUPN 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53674 36
tropical clawed frog
(Silurana tropicalis)
Amphibia snupn 36
  • 66.37 (n)
  • 71.08 (a)
Str.7297 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4465 36
zebrafish
(Danio rerio)
Actinopterygii snupn 36
  • 64.64 (n)
  • 66.38 (a)
snupn 37
  • 64 (a)
OneToOne
wufc41a03 36
fruit fly
(Drosophila melanogaster)
Insecta CG42303 37
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F23F1.5 36
  • 48.63 (n)
  • 44.44 (a)
F23F1.5 37
  • 41 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24880 36
  • 50.09 (n)
  • 44.13 (a)
rice
(Oryza sativa)
Liliopsida Os01g0101300 36
  • 47.73 (n)
  • 37.6 (a)
Species with no ortholog for SNUPN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNUPN Gene

ENSEMBL:
Gene Tree for SNUPN (if available)
TreeFam:
Gene Tree for SNUPN (if available)

Paralogs for SNUPN Gene

No data available for Paralogs for SNUPN Gene

Variants for SNUPN Gene

Sequence variations from dbSNP and Humsavar for SNUPN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1128585 -- 75,598,348(-) AGAAG(A/C)CTCCT utr-variant-3-prime
rs1139903 -- 75,598,646(-) ACCCA(C/T)TACAG reference, synonymous-codon
rs3210683 -- 75,598,271(-) GACTT(C/T)ATTCT utr-variant-3-prime
rs4371118 -- 75,606,549(+) GTGTT(A/C/G)TTAAC intron-variant
rs4499202 -- 75,604,180(+) TTTTG(G/T)GACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNUPN Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV Deletion 23290073
esv2749895 CNV Deletion 23290073

Relevant External Links for SNUPN Gene

HapMap Linkage Disequilibrium report
SNUPN

Disorders for SNUPN Gene

No disorders were found for SNUPN Gene.

No data available for UniProtKB/Swiss-Prot for SNUPN Gene

Publications for SNUPN Gene

  1. CRM1-mediated recycling of snurportin 1 to the cytoplasm. (PMID: 10209022) Paraskeva E. … Goerlich D. (J. Cell Biol. 1999) 3 4 23
  2. Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure. (PMID: 9670026) Huber J. … Luehrmann R. (EMBO J. 1998) 2 3 4
  3. SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. (PMID: 12095920) Narayanan U. … Matera A.G. (Hum. Mol. Genet. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Molecular determinants of snurportin 1 ligand affinity and structural response upon binding. (PMID: 19619473) Goette M. … GrubmA1ller H. (Biophys. J. 2009) 3 23

Products for SNUPN Gene

Sources for SNUPN Gene

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