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SNUPN Gene

protein-coding   GIFtS: 53
GCID: GC15M075890

Snurportin 1

(Previous names: RNA, U transporter 1)
(Previous symbol: RNUT1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Snurportin 11 2     KPNBL2
RNUT11 2 3     Snurportin12
RNA, U Transporter 11 2     snurportin-12
RNA U Transporter 12 3     SPN13

External Ids:    HGNC: 142451   Entrez Gene: 100732   Ensembl: ENSG000001693717   OMIM: 6079025   UniProtKB: O951493   

Export aliases for SNUPN gene to outside databases

Previous GC identifers: GC15M073678 GC15M052648


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNUPN Gene:
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear
localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of
the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and
functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the
same protein have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SNUPN Gene:
SNUPN (snurportin 1) is a protein-coding gene. Diseases associated with SNUPN include spinal muscular atrophy, and muscular atrophy. GO annotations related to this gene include protein transporter activity and RNA cap binding.

UniProtKB/Swiss-Prot: SPN1_HUMAN, O95149
Function: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine
(m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs

Gene Wiki entry for SNUPN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNUPN gene promoter:
         Pax-5   p53   MyoD   RelA   STAT5A   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNUPN promoter sequence
   Search Chromatin IP Primers for SNUPN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNUPN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q24.2

SNUPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNUPN gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075890:  view genomic region     (about GC identifiers)

Start:
75,890,424 bp from pter      End:
75,918,810 bp from pter
Size:
28,387 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPN1_HUMAN, O95149 (See protein sequence)
Recommended Name: Snurportin-1  
Size: 360 amino acids; 41143 Da
Subunit: Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear
export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN,
Ran and XPO1. Interacts with DDX20, IPO7, KPNB1, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its
interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive
Selected PDB 3D structures from and Proteopedia for SNUPN (see all 10):
1XK5 (3D)        2P8Q (3D)        2Q5D (3D)        2QNA (3D)        3GB8 (3D)        3GJX (3D)    
Secondary accessions: A6NE34 A8K0B0 D3DW76

Explore the universe of human proteins at neXtProt for SNUPN: NX_O95149

Explore proteomics data for SNUPN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys144, Lys228
  • Modification sites at PhosphoSitePlus

  • See SNUPN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001036046.1  NP_001036053.1  NP_005692.1  

    ENSEMBL proteins: 
     ENSP00000456224   ENSP00000309831   ENSP00000454852   ENSP00000458053   ENSP00000457562  
     ENSP00000456260   ENSP00000456742   ENSP00000457093   ENSP00000455894   ENSP00000455649  
     ENSP00000360132  
    Reactome Protein details: O95149

    SNUPN Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for SNUPN
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR024721 Snurportin-1_N
     IPR002652 Importin-a_IBB
     IPR017336 Snurportin-1

    Graphical View of Domain Structure for InterPro Entry O95149

    ProtoNet protein and cluster: O95149

    UniProtKB/Swiss-Prot: SPN1_HUMAN, O95149
    Similarity: Belongs to the snurportin family
    Similarity: Contains 1 IBB domain


    SNUPN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPN1_HUMAN, O95149
    Function: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine
    (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000339RNA cap binding TAS9670026
    GO:0005515protein binding ----
    GO:0008565protein transporter activity IEA--
         
    SNUPN for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SNUPN:
     Decreased viability with pacli  Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNUPN
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNUPN

    miRNA
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    miRTarBase miRNAs that target SNUPN:
    hsa-let-7c-5p (MIRT051834)

    Block miRNA regulation of human, mouse, rat SNUPN using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SNUPN
    SwitchGear 3'UTR luciferase reporter plasmidSNUPN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SNUPN

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNUPN

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNUPN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPN1_HUMAN, O95149: Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the
    nucleocytoplasmic transport receptor importin beta. It is re-exported to the cytoplasm by the XPO1-dependent
    nuclear export receptor pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005643nuclear pore TAS9670026
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    SNUPN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNUPN About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Metabolism of non-coding RNA0.54
    snRNP Assembly0.54
    2Gene Expression
    Gene Expression0.40
    3RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SNUPN
        snRNP Assembly


    1 Kegg Pathway  (Kegg details for SNUPN):
        RNA transport


    SNUPN for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNUPN
    Interactions:

        GeneGlobe Interaction Network for SNUPN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNUPN (O951492, 3 ENSP000003098314) via UniProtKB, MINT, STRING, and/or I2D (see all 631)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 I2D: score=1 STRING: ENSP00000370083
    RNF126Q9BV682, 3, ENSP000002923634MINT-8271894 I2D: score=2 STRING: ENSP00000292363
    SMN2Q166372, 3MINT-7945693 I2D: score=1 
    ENO2P091042, 3MINT-63267 I2D: score=4 
    PAFAH1B2P684022, 3MINT-63999 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0006606protein import into nucleus IEA--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0034660ncRNA metabolic process TAS--

    SNUPN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNUPN (SPN1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SNUPN gene (3 alternative transcripts): 
    NM_001042581.1  NM_001042588.1  NM_005701.3  

    Unigene Cluster for SNUPN:

    Snurportin 1
    Hs.21577  [show with all ESTs]
    Unigene Representative Sequence: NM_005701
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000567134(uc002ban.3) ENST00000308588(uc002baq.3 uc002bar.3 uc002bas.3)
    ENST00000564644 ENST00000564675 ENST00000567437 ENST00000568078 ENST00000569817
    ENST00000564086 ENST00000568162 ENST00000563793 ENST00000563875 ENST00000371091(uc002bap.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat SNUPN using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SNUPN
    SwitchGear 3'UTR luciferase reporter plasmidSNUPN 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SNUPN
    Predesigned siRNA for gene silencing in human, mouse, rat SNUPN
    Clone
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    OriGene ORF clones in mouse, rat for SNUPN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SNUPN (NM_005701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNUPN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNUPN
    Primer
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    OriGene qPCR primer pairs and template standards for SNUPN
    OriGene qSTAR qPCR primer pairs in human, mouse for SNUPN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNUPN
      QuantiTect SYBR Green Assays in human, mouse, rat SNUPN
      QuantiFast Probe-based Assays in human, mouse, rat SNUPN

    Additional mRNA sequence: 

    AF039029.1 AK289475.1 BC004203.2 CR456811.1 

    18 DOTS entries:

    DT.97843857  DT.121052922  DT.453822  DT.91739539  DT.100819633  DT.100698153  DT.75185804  DT.95175534 
    DT.100819631  DT.100819623  DT.121052942  DT.121052802  DT.91638379  DT.95077588  DT.100723295  DT.100801904 
    DT.100819630  DT.121052655 

    Selected AceView cDNA sequences (see all 225):

    AI753514 CR623423 BQ109441 BM708840 NM_005701 AI240250 BU186598 AA505679 
    CR623907 BE785698 BC004203 AA404426 BU932125 BI713095 BM702711 AI360986 
    BE464545 CR598709 AA404471 BI712142 AW025591 AI628449 AA701382 AA676858 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SNUPN (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
    SP1:                                -     -     -     -     -                                                           -               
    SP2:                                                                                                                    -               
    SP3:                                            -     -     -                                                                           
    SP4:                                                                                                                                    
    SP5:        -     -     -     -     -     -     -     -     -                                                                           


    ECgene alternative splicing isoforms for SNUPN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNUPN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SNUPN Expression
    About this image


    SNUPN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
    SNUPN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNUPN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.21577
        Custom PCR Arrays for SNUPN
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNUPN
    QuantiTect SYBR Green Assays in human, mouse, rat SNUPN
    QuantiFast Probe-based Assays in human, mouse, rat SNUPN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNUPN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNUPN gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snupn1 , 5 snurportin 11, 5 89.89(n)1
    93.26(a)1
      9 (30.57 cM)5
    660691  NM_178374.31  NP_848461.11 
     569508785 
    chicken
    (Gallus gallus)
    Aves SNUPN1 snurportin 1 70.57(n)
    69.92(a)
      770225  NM_001080878.1  NP_001074347.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNUPN6
    snurportin 1
    72(a)
    1 ↔ 1
    GL343374.1(5261-11566)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC536742 similar to RNA, U transporter 1 72.18(n)    BC043630.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc41a032 wufc41a03 73.01(n)   324743  BC062858.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423036
    --
    32(a)
    1 ↔ 1
    3L(2652088-2655455)
    worm
    (Caenorhabditis elegans)
    Secernentea F23F1.51 F23F1.5 48.63(n)
    44.44(a)
      173383  NM_061238.1  NP_493639.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G248801 AT4G24880 50.09(n)
    44.13(a)
      828590  NM_118620.3  NP_567711.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01013001 Os01g0101300 47.73(n)
    37.6(a)
      4326461  NM_001048277.1  NP_001041742.1 


    ENSEMBL Gene Tree for SNUPN (if available)
    TreeFam Gene Tree for SNUPN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNUPN (see all 504)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440116721,2
    --75890160(+) ACTACA/GTTTGC 3 -- ds50010--------
    rs1399285621,2
    C--75890249(+) AATTGC/TAGTTC 3 -- ds50010--------
    rs745657041,2
    C,F--75890494(+) GCTCAA/GATCAA 3 -- ut311Minor allele frequency- G:0.03WA 118
    rs1434416611,2
    --75890519(+) AATCTA/GGGAAC 3 -- ut310--------
    rs1865684971,2
    --75890562(+) TTATAC/GATAAG 3 -- ut310--------
    rs32106831,2
    C,F,H--75890612(-) GACTTC/TATTCT 3 -- ut3121Minor allele frequency- T:0.09MN NS EA NA WA 2768
    rs1467702031,2
    --75890629(+) TGTCAC/TTGTCC 3 -- ut310--------
    rs11285851,2
    C,F,O,H--75890689(-) AGAAGC/ACTCCT 3 -- ut3118Minor allele frequency- A:0.12MN NS EA NA WA EU 3653
    rs1382169791,2
    C--75890761(+) GGGAGT/GAGACA 6 /T /P mis11Minor allele frequency- G:0.00EU 1323
    rs1412068051,2
    C,F--75890842(+) GCTCTT/CCTTGT 6 /K /E mis11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for SNUPN (75890424 - 75918810 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SNUPN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749894CNV Deletion23290073
    esv2749895CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNUPN
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607902    OMIM disorders: --

    2 diseases for SNUPN:    
    About MalaCards
    spinal muscular atrophy    muscular atrophy


    SNUPN for disorders           About GeneDecksing


    Export disorders for SNUPN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNUPN gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with SNUPN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure. (PubMed id 9670026)1, 2, 3 Huber J.... Luehrmann R. (EMBO J. 1998)
    2. CRM1-mediated recycling of snurportin 1 to the cytoplasm. (PubMed id 10209022)1, 2, 9 Paraskeva E.... Goerlich D. (J. Cell Biol. 1999)
    3. Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1. (PubMed id 15920472)1, 2 Strasser A.... Ficner R. (EMBO J. 2005)
    4. Cross-talk between snurportin1 subdomains. (PubMed id 16030253)1, 2 Ospina J.K....Matera A.G. (Mol. Biol. Cell 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. (PubMed id 12095920)1, 2 Narayanan U.... Matera A.G. (Hum. Mol. Genet. 2002)
    8. Molecular determinants of snurportin 1 ligand affinity and structural response upon binding. (PubMed id 19619473)1, 9 Goette M....GrubmA1ller H. (Biophys. J. 2009)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Sequence and structural analyses of nuclear export signals in the NESdb database. (PubMed id 22833565)1 Xu D....Chook Y.M. (Mol. Biol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10073 HGNC: 14245 AceView: RNUT1 Ensembl:ENSG00000169371 euGenes: HUgn10073
    ECgene: SNUPN Kegg: 10073 H-InvDB: SNUPN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SNUPN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SNUPN gene:
    Search GeneIP for patents involving SNUPN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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