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Aliases for SNUPN Gene

Aliases for SNUPN Gene

  • Snurportin 1 2 3 5
  • RNA U Transporter 1 3 4
  • RNUT1 3 4
  • RNA, U Transporter 1 2
  • Snurportin-1 3
  • Snurportin1 3
  • KPNBL 3
  • SPN1 4

External Ids for SNUPN Gene

Previous HGNC Symbols for SNUPN Gene

  • RNUT1

Previous GeneCards Identifiers for SNUPN Gene

  • GC15M073678
  • GC15M075890
  • GC15M052648

Summaries for SNUPN Gene

Entrez Gene Summary for SNUPN Gene

  • The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNUPN Gene

SNUPN (Snurportin 1) is a Protein Coding gene. Among its related pathways are Transport of the SLBP independent Mature mRNA and RNA transport. GO annotations related to this gene include protein transporter activity and RNA cap binding.

UniProtKB/Swiss-Prot for SNUPN Gene

  • Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.

Gene Wiki entry for SNUPN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNUPN Gene

Genomics for SNUPN Gene

Regulatory Elements for SNUPN Gene

Enhancers for SNUPN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F075593 0.7 FANTOM5 35.8 +32.5 32484 0.0 ZGPAT KDM1A SNUPN ENSG00000260269 PTPN9
GH15F075346 0.8 Ensembl ENCODE 32.6 +277.4 277356 5.0 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ENSG00000260274 FBXO22 SNUPN EDC3 DNM1P35 SNX33 LOC105370902 DNM1P49 LOC441728 ENSG00000203392
GH15F075445 0.5 ENCODE 32.3 +180.2 180224 0.9 HDGF ATF1 ARNT CREB3L1 SIN3A ZNF2 ZNF48 ZNF121 GLIS2 ZNF416 SNUPN EDC3 ENSG00000260274 FBXO22 DNM1P35 MAN2C1 MIR631 ENSG00000276744 ENSG00000261714
GH15F075624 0.7 ENCODE 26.8 +0.2 240 3.8 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000260274 SNUPN TYRO3P MAN2C1 FBXO22 EDC3 COMMD4 ENSG00000260235
GH15F075619 0.5 ENCODE 26.2 +5.1 5093 3.2 ZNF121 SCRT1 CTCF SCRT2 JUN SMC3 MAN2C1 SNUPN ENSG00000260274 PTPN9 IMP3 SNX33 ENSG00000203392 CSPG4 MIR631 ENSG00000260235
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SNUPN on UCSC Golden Path with GeneCards custom track

Promoters for SNUPN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000022245 969 2201 HDGF CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for SNUPN Gene

Chromosome:
15
Start:
75,598,083 bp from pter
End:
75,626,469 bp from pter
Size:
28,387 bases
Orientation:
Minus strand

Genomic View for SNUPN Gene

Genes around SNUPN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNUPN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNUPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNUPN Gene

Proteins for SNUPN Gene

  • Protein details for SNUPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95149-SPN1_HUMAN
    Recommended name:
    Snurportin-1
    Protein Accession:
    O95149
    Secondary Accessions:
    • A6NE34
    • A8K0B0
    • D3DW76

    Protein attributes for SNUPN Gene

    Size:
    360 amino acids
    Molecular mass:
    41143 Da
    Quaternary structure:
    • Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts (via IBB domain) with KPNB1; the interaction is direct. Interacts with DDX20, IPO7, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive.

    Three dimensional structures from OCA and Proteopedia for SNUPN Gene

neXtProt entry for SNUPN Gene

Post-translational modifications for SNUPN Gene

  • Ubiquitination at Lys 144 and Lys 228
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for SNUPN

No data available for DME Specific Peptides for SNUPN Gene

Domains & Families for SNUPN Gene

Protein Domains for SNUPN Gene

Suggested Antigen Peptide Sequences for SNUPN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95149

UniProtKB/Swiss-Prot:

SPN1_HUMAN :
  • Contains 1 IBB domain.
  • Belongs to the snurportin family.
Domain:
  • Contains 1 IBB domain.
Family:
  • Belongs to the snurportin family.
genes like me logo Genes that share domains with SNUPN: view

No data available for Gene Families for SNUPN Gene

Function for SNUPN Gene

Molecular function for SNUPN Gene

UniProtKB/Swiss-Prot Function:
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.

Gene Ontology (GO) - Molecular Function for SNUPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding TAS 9670026
GO:0003723 RNA binding IEA --
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with SNUPN: view
genes like me logo Genes that share phenotypes with SNUPN: view

Animal Model Products

miRNA for SNUPN Gene

miRTarBase miRNAs that target SNUPN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNUPN Gene

Localization for SNUPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNUPN Gene

Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920). It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway (PubMed:10209022). {ECO:0000269 PubMed:10209022, ECO:0000269 PubMed:12095920}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNUPN Gene COMPARTMENTS Subcellular localization image for SNUPN gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for SNUPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore TAS 9670026
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SNUPN: view

Pathways & Interactions for SNUPN Gene

genes like me logo Genes that share pathways with SNUPN: view

Pathways by source for SNUPN Gene

3 Reactome pathways for SNUPN Gene
1 KEGG pathway for SNUPN Gene

Gene Ontology (GO) - Biological Process for SNUPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0006606 protein import into nucleus IEA --
GO:0006810 transport IEA --
GO:0051170 nuclear import TAS --
GO:0061015 snRNA import into nucleus IEA --
genes like me logo Genes that share ontologies with SNUPN: view

No data available for SIGNOR curated interactions for SNUPN Gene

Transcripts for SNUPN Gene

Unigene Clusters for SNUPN Gene

Snurportin 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNUPN Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - -
SP2: -
SP3: - - -
SP4:
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: -
SP9:

Relevant External Links for SNUPN Gene

GeneLoc Exon Structure for
SNUPN
ECgene alternative splicing isoforms for
SNUPN

Expression for SNUPN Gene

mRNA expression in normal human tissues for SNUPN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNUPN Gene

This gene is overexpressed in Adrenal (36.9), Breast (18.2), and Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNUPN Gene



NURSA nuclear receptor signaling pathways regulating expression of SNUPN Gene:

SNUPN

SOURCE GeneReport for Unigene cluster for SNUPN Gene:

Hs.21577
genes like me logo Genes that share expression patterns with SNUPN: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SNUPN Gene

Orthologs for SNUPN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNUPN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNUPN 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia SNUPN 34 35
  • 90.17 (n)
cow
(Bos Taurus)
Mammalia SNUPN 34 35
  • 89.91 (n)
mouse
(Mus musculus)
Mammalia Snupn 34 16 35
  • 89.89 (n)
rat
(Rattus norvegicus)
Mammalia Snupn 34
  • 89.55 (n)
oppossum
(Monodelphis domestica)
Mammalia SNUPN 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 80 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves SNUPN 34 35
  • 70.57 (n)
lizard
(Anolis carolinensis)
Reptilia SNUPN 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snupn 34
  • 66.37 (n)
Str.7297 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53674 34
zebrafish
(Danio rerio)
Actinopterygii snupn 34 35
  • 64.64 (n)
wufc41a03 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4465 34
fruit fly
(Drosophila melanogaster)
Insecta CG42303 35
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F23F1.5 34 35
  • 48.63 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24880 34
  • 50.09 (n)
rice
(Oryza sativa)
Liliopsida Os01g0101300 34
  • 47.73 (n)
Species where no ortholog for SNUPN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNUPN Gene

ENSEMBL:
Gene Tree for SNUPN (if available)
TreeFam:
Gene Tree for SNUPN (if available)

Paralogs for SNUPN Gene

No data available for Paralogs for SNUPN Gene

Variants for SNUPN Gene

Sequence variations from dbSNP and Humsavar for SNUPN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10163126 -- 75,627,838(+) AGTCA(C/T)GGCTG upstream-variant-2KB
rs11072552 -- 75,600,747(+) GAAGC(A/C)CCTTC intron-variant
rs111247708 -- 75,619,230(+) GAGGG(G/T)CTGAG intron-variant
rs111274645 -- 75,609,285(+) CCTGG(A/G)TTCAC intron-variant
rs111481276 -- 75,624,782(+) TTGTT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNUPN Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV deletion 23290073
esv2749895 CNV deletion 23290073
esv3636927 CNV loss 21293372
nsv1116463 OTHER inversion 24896259
nsv1127445 CNV deletion 24896259

Variation tolerance for SNUPN Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNUPN Gene

Human Gene Mutation Database (HGMD)
SNUPN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNUPN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNUPN Gene

Disorders for SNUPN Gene

Relevant External Links for SNUPN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNUPN

No disorders were found for SNUPN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNUPN Gene

Publications for SNUPN Gene

  1. CRM1-mediated recycling of snurportin 1 to the cytoplasm. (PMID: 10209022) Paraskeva E. … Goerlich D. (J. Cell Biol. 1999) 3 4 22 64
  2. Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure. (PMID: 9670026) Huber J. … Luehrmann R. (EMBO J. 1998) 2 3 4 64
  3. Molecular determinants of snurportin 1 ligand affinity and structural response upon binding. (PMID: 19619473) Goette M. … GrubmA1ller H. (Biophys. J. 2009) 3 22 64
  4. Molecular basis for the recognition of snurportin 1 by importin beta. (PMID: 18187419) Mitrousis G. … Cingolani G. (J. Biol. Chem. 2008) 4 22 64
  5. Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1. (PMID: 15920472) Strasser A. … Ficner R. (EMBO J. 2005) 3 4 64

Products for SNUPN Gene

Sources for SNUPN Gene

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