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Aliases for SNU13 Gene

Aliases for SNU13 Gene

  • Small Nuclear Ribonucleoprotein 13 2 3
  • SNU13 Homolog, Small Nuclear Ribonucleoprotein (U4/U6.U5) 2 3 5
  • High Mobility Group-Like Nuclear Protein 2 Homolog 1 3 4
  • U4/U6.U5 Tri-SnRNP 15.5 KDa Protein 3 4
  • Sperm Specific Antigen 1 2 3
  • NHP2L1 3 4
  • OTK27 3 4
  • NHP2 Non-Histone Chromosome Protein 2-Like 1 (S. Cerevisiae) 2
  • Non-Histone Chromosome Protein 2 (S. Cerevisiae)-Like 1 2
  • Small Nuclear Ribonucleoprotein 15.5kDa (U4/U6.U5) 2
  • [U4/U6.U5] Tri-SnRNP 15.5 KD RNA Binding Protein 3
  • U4/U6.U5 Small Nuclear Ribonucleoprotein SNU13 4
  • NHP2 Non-Histone Chromosome Protein 2-Like 1 3
  • Non-Histone Chromosome Protein 2-Like 1 3
  • NHP2-Like Protein 1 3
  • SNU13 Homolog 4
  • SNRNP15-5 3
  • SPAG12 3
  • HSNU13 4
  • 15.5K 3
  • SSFA1 3
  • FA-1 3
  • NHPX 3
  • FA1 3

External Ids for SNU13 Gene

Previous HGNC Symbols for SNU13 Gene

  • SSFA1
  • NHP2L1

Previous GeneCards Identifiers for SNU13 Gene

  • GC22M041674

Summaries for SNU13 Gene

Entrez Gene Summary for SNU13 Gene

  • Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNU13 Gene

SNU13 (Small Nuclear Ribonucleoprotein 13) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and rRNA processing in the nucleus and cytosol.

UniProtKB/Swiss-Prot for SNU13 Gene

  • Binds to the 5-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.

Gene Wiki entry for SNU13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNU13 Gene

Genomics for SNU13 Gene

Regulatory Elements for SNU13 Gene

Enhancers for SNU13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G040709 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +978.3 978332 6.3 MLX FEZF1 ZNF416 ZNF263 SP3 MEF2D ZNF610 ZNF585B GLIS1 RCOR2 SNU13 ENSG00000235513 SLC25A17 EP300 XPNPEP3 GC22M041364 LOC100313968
GH22G041559 1.6 Ensembl ENCODE dbSUPER 11.2 +127.4 127422 6.9 HDGF PKNOX1 ZFP64 ARID4B ZNF302 ZNF143 FOS ZNF263 SP3 ZNF662 EP300 XRCC6 PHF5A MEI1 POLR3H DNAJB7 CSDC2 TOB2 DESI1 SNU13
GH22G041444 1.8 FANTOM5 ENCODE dbSUPER 9.9 +243.8 243789 5.9 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 PHF5A EP300 MEI1 POLR3H ACO2 CYP2D8P NDUFA6-AS1 NAGA SMDT1 XRCC6
GH22G041379 1.7 FANTOM5 ENCODE dbSUPER 9.9 +308.5 308541 4.0 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A YY1 FOS SP3 SP5 EP300 MEI1 POLR3H EP300-AS1 ENSG00000272834 XRCC6 PHF5A LOC100313968 ENSG00000227413 ENSG00000232754
GH22G041666 1.4 Ensembl ENCODE 11.5 +23.1 23061 2.5 HDGF PKNOX1 FOXA2 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RN7SKP80 EP300 PHF5A RRP7BP MEI1 EP300-AS1 XRCC6 LOC100313968 ENSG00000232754 SNU13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNU13 on UCSC Golden Path with GeneCards custom track

Promoters for SNU13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146655 1904 2001 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS

Genomic Location for SNU13 Gene

Chromosome:
22
Start:
41,673,930 bp from pter
End:
41,690,504 bp from pter
Size:
16,575 bases
Orientation:
Minus strand

Genomic View for SNU13 Gene

Genes around SNU13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNU13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNU13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNU13 Gene

Proteins for SNU13 Gene

  • Protein details for SNU13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55769-NH2L1_HUMAN
    Recommended name:
    NHP2-like protein 1
    Protein Accession:
    P55769

    Protein attributes for SNU13 Gene

    Size:
    128 amino acids
    Molecular mass:
    14174 Da
    Quaternary structure:
    • Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31.

    Three dimensional structures from OCA and Proteopedia for SNU13 Gene

neXtProt entry for SNU13 Gene

Post-translational modifications for SNU13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNU13 Gene

No data available for DME Specific Peptides for SNU13 Gene

Domains & Families for SNU13 Gene

Graphical View of Domain Structure for InterPro Entry

P55769

UniProtKB/Swiss-Prot:

NH2L1_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL8 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL8 family.
genes like me logo Genes that share domains with SNU13: view

No data available for Gene Families for SNU13 Gene

Function for SNU13 Gene

Molecular function for SNU13 Gene

UniProtKB/Swiss-Prot Function:
Binds to the 5-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.

Gene Ontology (GO) - Molecular Function for SNU13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,IEA 22658674
GO:0005515 protein binding IPI 10593953
GO:0030515 contributes_to snoRNA binding IDA 17636026
GO:0030621 U4 snRNA binding IDA 11081632
GO:0030622 U4atac snRNA binding IDA 16857676
genes like me logo Genes that share ontologies with SNU13: view
genes like me logo Genes that share phenotypes with SNU13: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SNU13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNU13 Gene

Localization for SNU13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNU13 Gene

Nucleus, nucleolus. Note=Concentrated in the dense fibrillar component of the nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNU13 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for SNU13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001651 dense fibrillar component IDA 10593953
GO:0005634 nucleus TAS 8978773
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005730 nucleolus IDA,IEA 10593953
genes like me logo Genes that share ontologies with SNU13: view

Pathways & Interactions for SNU13 Gene

genes like me logo Genes that share pathways with SNU13: view

Pathways by source for SNU13 Gene

Gene Ontology (GO) - Biological Process for SNU13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0000470 maturation of LSU-rRNA IBA --
GO:0000492 box C/D snoRNP assembly IEA --
GO:0006364 rRNA processing TAS --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with SNU13: view

No data available for SIGNOR curated interactions for SNU13 Gene

Drugs & Compounds for SNU13 Gene

(2) Drugs for SNU13 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific 0
genes like me logo Genes that share compounds with SNU13: view

Transcripts for SNU13 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SNU13

Alternative Splicing Database (ASD) splice patterns (SP) for SNU13 Gene

No ASD Table

Relevant External Links for SNU13 Gene

GeneLoc Exon Structure for
SNU13
ECgene alternative splicing isoforms for
SNU13

Expression for SNU13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SNU13 Gene:

SNU13

mRNA Expression by UniProt/SwissProt for SNU13 Gene:

P55769-NH2L1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SNU13 Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Liver(4.6)
  • Skin(4.1)
  • Blood(2.9)
  • Eye(2.5)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with SNU13: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNU13 Gene

Orthologs for SNU13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNU13 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gm5616 35
  • 100 (a)
OneToMany
Nhp2l1 35 34
  • 89.84 (n)
OneToMany
Snu13 16
chimpanzee
(Pan troglodytes)
Mammalia NHP2L1 34 35
  • 98.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NHP2L1 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NHP2L1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NHP2L1 34 35
  • 93.75 (n)
cow
(Bos Taurus)
Mammalia NHP2L1 34 35
  • 90.62 (n)
rat
(Rattus norvegicus)
Mammalia Nhp2l1 34
  • 89.32 (n)
chicken
(Gallus gallus)
Aves NHP2L1 34 35
  • 79.27 (n)
lizard
(Anolis carolinensis)
Reptilia NHP2L1 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nhp2l1 34
  • 77.86 (n)
MGC75724 34
zebrafish
(Danio rerio)
Actinopterygii nhp2l1a 35
  • 90 (a)
OneToMany
nhp2l1b 34 35
  • 78.12 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8678 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008163 34
  • 72.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta hoip 34 35
  • 72.44 (n)
worm
(Caenorhabditis elegans)
Secernentea M28.5 34 35
  • 70.83 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL070W 34
  • 65.3 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNU13 34 35 37
  • 63.66 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22529g 34
  • 63.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G20160 34
  • 68.23 (n)
rice
(Oryza sativa)
Liliopsida Os03g0241200 34
  • 69.53 (n)
Os.12755 34
barley
(Hordeum vulgare)
Liliopsida Hv.12809 34
wheat
(Triticum aestivum)
Liliopsida Ta.12661 34
corn
(Zea mays)
Liliopsida Zm.2052 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5606 35
  • 78 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes snu13 34
  • 63.69 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01331 34
  • 62.68 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4606 34
Species where no ortholog for SNU13 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SNU13 Gene

ENSEMBL:
Gene Tree for SNU13 (if available)
TreeFam:
Gene Tree for SNU13 (if available)

Paralogs for SNU13 Gene

genes like me logo Genes that share paralogs with SNU13: view

No data available for Paralogs for SNU13 Gene

Variants for SNU13 Gene

Sequence variations from dbSNP and Humsavar for SNU13 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000174801 -- 41,688,985(+) CCCTG(C/T)GTCGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000210108 -- 41,685,704(+) CTCAC(G/T)CCTGT intron-variant
rs1000255517 -- 41,677,086(+) AGCAC(A/G)CATCT intron-variant, nc-transcript-variant
rs1000266051 -- 41,691,448(+) TTTTT(G/T)TACTT intron-variant, upstream-variant-2KB
rs1000288149 -- 41,677,414(+) CAGCT(A/G)CCTGG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SNU13 Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV loss 19592680
nsv834209 CNV loss 17160897

Variation tolerance for SNU13 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNU13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNU13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNU13 Gene

Disorders for SNU13 Gene

Relevant External Links for SNU13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNU13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNU13

No disorders were found for SNU13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNU13 Gene

Publications for SNU13 Gene

  1. Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2. (PMID: 8978773) Saito H. … Nakamura Y. (Cytogenet. Cell Genet. 1996) 2 3 4 22 64
  2. Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. (PMID: 17412961) Liu S. … Wahl M.C. (Science 2007) 2 3 4 64
  3. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. (PMID: 17636026) McKeegan K.S. … Watkins N.J. (Mol. Cell. Biol. 2007) 2 3 64
  4. Functional implications for a prototypical K-turn binding protein from structural and dynamical studies of 15.5K. (PMID: 18044964) Soss S.E. … Flynn P.F. (Biochemistry 2007) 3 4 64
  5. The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. (PMID: 16723661) Liu S. … Luehrmann R. (RNA 2006) 3 4 64

Products for SNU13 Gene

  • Addgene plasmids for SNU13

Sources for SNU13 Gene

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