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Aliases for SNU13 Gene

Aliases for SNU13 Gene

  • SNU13 Homolog, Small Nuclear Ribonucleoprotein (U4/U6.U5) 2 3 5
  • High Mobility Group-Like Nuclear Protein 2 Homolog 1 3 4
  • Small Nuclear Ribonucleoprotein 15.5kDa (U4/U6.U5) 2 3
  • U4/U6.U5 Small Nuclear Ribonucleoprotein SNU13 3 4
  • U4/U6.U5 Tri-SnRNP 15.5 KDa Protein 3 4
  • Sperm Specific Antigen 1 2 3
  • NHP2L1 3 4
  • OTK27 3 4
  • NHP2 Non-Histone Chromosome Protein 2-Like 1 (S. Cerevisiae) 2
  • Non-Histone Chromosome Protein 2 (S. Cerevisiae)-Like 1 2
  • [U4/U6.U5] Tri-SnRNP 15.5 KD RNA Binding Protein 3
  • NHP2 Non-Histone Chromosome Protein 2-Like 1 3
  • Non-Histone Chromosome Protein 2-Like 1 3
  • SNU13 Homolog 4
  • SNRNP15-5 3
  • SPAG12 3
  • HSNU13 4
  • 15.5K 3
  • SSFA1 3
  • FA-1 3
  • NHPX 3
  • FA1 3

External Ids for SNU13 Gene

Previous HGNC Symbols for SNU13 Gene

  • SSFA1
  • NHP2L1

Summaries for SNU13 Gene

Entrez Gene Summary for SNU13 Gene

  • Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNU13 Gene

SNU13 (SNU13 Homolog, Small Nuclear Ribonucleoprotein (U4/U6.U5)) is a Protein Coding gene. Diseases associated with SNU13 include fanconi anemia, complementation group a. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway.

UniProtKB/Swiss-Prot for SNU13 Gene

  • Binds to the 5-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.

Gene Wiki entry for SNU13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNU13 Gene

Genomics for SNU13 Gene

Regulatory Elements for SNU13 Gene

Promoters for SNU13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNU13 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNU13 Gene

Chromosome:
22
Start:
41,673,930 bp from pter
End:
41,690,504 bp from pter
Size:
16,575 bases
Orientation:
Minus strand

Genomic View for SNU13 Gene

Genes around SNU13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNU13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNU13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNU13 Gene

Proteins for SNU13 Gene

  • Protein details for SNU13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55769-NH2L1_HUMAN
    Recommended name:
    NHP2-like protein 1
    Protein Accession:
    P55769

    Protein attributes for SNU13 Gene

    Size:
    128 amino acids
    Molecular mass:
    14174 Da
    Quaternary structure:
    • Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31.

    Three dimensional structures from OCA and Proteopedia for SNU13 Gene

neXtProt entry for SNU13 Gene

Proteomics data for SNU13 Gene at MOPED

Post-translational modifications for SNU13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNU13 Gene

No data available for DME Specific Peptides for SNU13 Gene

Domains & Families for SNU13 Gene

Graphical View of Domain Structure for InterPro Entry

P55769

UniProtKB/Swiss-Prot:

NH2L1_HUMAN :
  • Belongs to the ribosomal protein L7Ae family.
Family:
  • Belongs to the ribosomal protein L7Ae family.
genes like me logo Genes that share domains with SNU13: view

No data available for Gene Families for SNU13 Gene

Function for SNU13 Gene

Molecular function for SNU13 Gene

UniProtKB/Swiss-Prot Function:
Binds to the 5-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.

Gene Ontology (GO) - Molecular Function for SNU13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17412961
GO:0030621 U4 snRNA binding IDA 11081632
GO:0030622 U4atac snRNA binding IDA 16857676
GO:0034512 box C/D snoRNA binding IDA 11081632
GO:0051117 ATPase binding IPI 17636026
genes like me logo Genes that share ontologies with SNU13: view
genes like me logo Genes that share phenotypes with SNU13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SNU13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNU13 Gene

Localization for SNU13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNU13 Gene

Nucleus, nucleolus. Note=Concentrated in the dense fibrillar component of the nucleolus.

Gene Ontology (GO) - Cellular Components for SNU13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8978773
GO:0005730 nucleolus IEA,TAS 10593953
GO:0043234 protein complex IDA 17636026
genes like me logo Genes that share ontologies with SNU13: view

No data available for Subcellular locations from COMPARTMENTS for SNU13 Gene

Pathways & Interactions for SNU13 Gene

genes like me logo Genes that share pathways with SNU13: view

Gene Ontology (GO) - Biological Process for SNU13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with SNU13: view

No data available for SIGNOR curated interactions for SNU13 Gene

Drugs & Compounds for SNU13 Gene

(2) Drugs for SNU13 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
anisomycin Experimental Pharma Target JNK, SAPK and p38 activator 0
genes like me logo Genes that share compounds with SNU13: view

Transcripts for SNU13 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SNU13 Gene

No ASD Table

Relevant External Links for SNU13 Gene

GeneLoc Exon Structure for
SNU13
ECgene alternative splicing isoforms for
SNU13

Expression for SNU13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA Expression by UniProt/SwissProt for SNU13 Gene

P55769-NH2L1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SNU13: view

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SNU13 Gene

Orthologs for SNU13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNU13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NHP2L1 35
  • 90.62 (n)
  • 100 (a)
NHP2L1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NHP2L1 35
  • 93.75 (n)
  • 100 (a)
NHP2L1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nhp2l1 35
  • 89.84 (n)
  • 100 (a)
Nhp2l1 16
Gm5616 36
  • 100 (a)
OneToMany
Nhp2l1 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia NHP2L1 35
  • 98.96 (n)
  • 100 (a)
NHP2L1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nhp2l1 35
  • 89.32 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia NHP2L1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NHP2L1 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves NHP2L1 35
  • 79.27 (n)
  • 92.91 (a)
NHP2L1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NHP2L1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75724 35
nhp2l1 35
  • 77.86 (n)
  • 92.19 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
nhp2l1b 35
  • 78.12 (n)
  • 90.62 (a)
nhp2l1a 36
  • 90 (a)
OneToMany
nhp2l1b 36
  • 91 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8678 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008163 35
  • 72.58 (n)
  • 83.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta hoip 35
  • 72.44 (n)
  • 78.74 (a)
hoip 36
  • 76 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M28.5 35
  • 70.83 (n)
  • 77.34 (a)
M28.5 36
  • 77 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL070W 35
  • 65.3 (n)
  • 71.31 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22529g 35
  • 63.11 (n)
  • 70.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNU13 35
  • 63.66 (n)
  • 71.31 (a)
SNU13 36
  • 69 (a)
OneToOne
SNU13 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G20160 35
  • 68.23 (n)
  • 78.12 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12809 35
rice
(Oryza sativa)
Liliopsida Os.12755 35
Os03g0241200 35
  • 69.53 (n)
  • 78.12 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.12661 35
corn
(Zea mays)
Liliopsida Zm.2052 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4606 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01331 35
  • 62.68 (n)
  • 60.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes snu13 35
  • 63.69 (n)
  • 76.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5606 36
  • 78 (a)
OneToOne
Species with no ortholog for SNU13:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SNU13 Gene

ENSEMBL:
Gene Tree for SNU13 (if available)
TreeFam:
Gene Tree for SNU13 (if available)

Paralogs for SNU13 Gene

genes like me logo Genes that share paralogs with SNU13: view

No data available for Paralogs for SNU13 Gene

Variants for SNU13 Gene

Sequence variations from dbSNP and Humsavar for SNU13 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1802521 - 41,680,312(-) CCTCA(A/C)CAAGA reference, missense, utr-variant-3-prime
rs132806 -- 41,674,789(+) AAAAA(C/T)AACAC utr-variant-3-prime
rs132807 -- 41,675,580(+) CTGTG(C/T)TTAGC intron-variant
rs8779 -- 41,674,272(-) GAGGC(A/G)GCCTG utr-variant-3-prime
rs13149 -- 41,674,808(-) ATCTG(A/G)TTTCT utr-variant-3-prime

Variation tolerance for SNU13 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNU13 Gene

HapMap Linkage Disequilibrium report
SNU13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SNU13 Gene

Disorders for SNU13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNU13 Gene - From: OMIM

Disorder Aliases PubMed IDs
fanconi anemia, complementation group a
  • fanconi's anemia
- elite association - COSMIC cancer census association via MalaCards
Search SNU13 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SNU13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNU13
genes like me logo Genes that share disorders with SNU13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNU13 Gene

Publications for SNU13 Gene

  1. Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2. (PMID: 8978773) Saito H. … Nakamura Y. (Cytogenet. Cell Genet. 1996) 2 3 4 23 67
  2. Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. (PMID: 17412961) Liu S. … Wahl M.C. (Science 2007) 2 3
  3. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. (PMID: 17636026) McKeegan K.S. … Watkins N.J. (Mol. Cell. Biol. 2007) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SNU13 Gene

Sources for SNU13 Gene

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