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SNTN Gene

protein-coding   GIFtS: 40
GCID: GC03P063616

Sentan, Cilia Apical Structure Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sentan, Cilia Apical Structure Protein1 2     sentan2
S100A-Like Protein1 2     Protein S100-A1-Like3
S100A1L2 3     S100 Calcium-Binding Protein A1-Like3
S100AL2     

External Ids:    HGNC: 337061   Entrez Gene: 1322032   Ensembl: ENSG000001888177   UniProtKB: A6NMZ23   

Export aliases for SNTN gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SNTN Gene:
SNTN (sentan, cilia apical structure protein) is a protein-coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot: SNTAN_HUMAN, A6NMZ2
Function: May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet
microtubules (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNTN gene promoter:
         AP-2rep   HOXA9   HOXA9B   CUTL1   S8   FOXO1a   Meis-1a   LyF-1   Meis-1   FOXO1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.2   Ensembl cytogenetic band:  3p14.2   HGNC cytogenetic band: 3p14.2

SNTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNTN gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P063616:  view genomic region     (about GC identifiers)

Start:
63,638,344 bp from pter      End:
63,664,696 bp from pter
Size:
26,353 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: SNTAN_HUMAN, A6NMZ2 (See protein sequence)
Recommended Name: Sentan  
Size: 147 amino acids; 16468 Da
Miscellaneous: 'Sentan' means 'tip' in Japanese
Secondary accessions: B7FF65

Explore the universe of human proteins at neXtProt for SNTN: NX_A6NMZ2

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_001074006.1  
    ENSEMBL proteins: 
     ENSP00000341442   ENSP00000420078   ENSP00000419971  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR026790 Sentan

    Graphical View of Domain Structure for InterPro Entry A6NMZ2

    ProtoNet protein and cluster: A6NMZ2

    UniProtKB/Swiss-Prot: SNTAN_HUMAN, A6NMZ2
    Similarity: Belongs to the S-100 family


    Find genes that share domains with SNTN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNTAN_HUMAN, A6NMZ2
    Function: May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet
    microtubules (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with SNTN           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SNTN

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNTAN_HUMAN, A6NMZ2: Cell projection, cilium (By similarity). Note=Expressed exclusively at the cilium tip where
    it localizes between the cell membrane and peripheral A-subfibers (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005929cilium IEA--

    Find genes that share ontologies with SNTN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SNTN (SNTAN)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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    REFSEQ mRNAs for SNTN gene: 
    NM_001080537.1  

    Unigene Cluster for SNTN:

    Sentan, cilia apical structure protein
    Hs.130704  [show with all ESTs]
    Unigene Representative Sequence: AK126350
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343837(uc003dlr.3) ENST00000469440 ENST00000496807
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    Additional mRNA sequence: AK126350.1 

    5 DOTS entries:

    DT.402975  DT.120863585  DT.101975414  DT.120863558  DT.100735586 

    Selected AceView cDNA sequences (see all 49):

    AI221311 BQ879653 AI687452 AA906188 BI771256 AI683666 BM978728 AA359824 
    BU101660 BG547093 BG534032 BM979832 AK126350 BG542228 BV188688 AW513603 
    AA927213 BM969265 BU679212 BG483873 BX283104 CD700315 CD685391 CD696773 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNTN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGCCAGGC
    SNTN Expression
    About this image

    SNTN Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.130704
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SNTN gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sntn1 , 5 sentan, cilia apical structure protein1, 5 82.99(n)1
    72.11(a)1
      14 (6.93 cM)5
    2187391  NM_177624.31  NP_808292.11 
     136708765 
    chicken
    (Gallus gallus)
    Aves SNTN1 sentan, cilia apical structure protein 62.73(n)
    57.64(a)
      416076  NM_001142847.1  NP_001136319.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNTN6
    sentan, cilia apical structure protein
    55(a)
    1 ↔ 1
    GL343210.1(2126163-2137004)


    ENSEMBL Gene Tree for SNTN (if available)
    TreeFam Gene Tree for SNTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNTN gene
    1 SIMAP similar gene for SNTN using alignment to 3 protein entries:     SNTAN_HUMAN (see all proteins):
    S100A1

    Find genes that share paralogs with SNTN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNTN (see all 345)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419038111,2
    --63636368(+) GGATGC/TGGAGA 1 -- us2k10--------
    rs1870072021,2
    --63636413(+) AAATTC/TGTTCA 1 -- us2k10--------
    rs1915798411,2
    --63636553(+) ACGTAC/TGTTTA 1 -- us2k10--------
    rs1477724111,2
    --63636576(+) TCACAA/GTAGCA 1 -- us2k10--------
    rs130855101,2
    F--63636581(+) atagcA/Caatac 1 -- us2k12Minor allele frequency- C:0.25NA 4
    rs130855131,2
    F--63636582(+) tagcaA/Gatact 1 -- us2k12Minor allele frequency- G:0.25NA 4
    rs130855191,2
    C,F--63636596(+) aaccaA/Ccctaa 1 -- us2k14Minor allele frequency- C:0.43NA CSA 7
    rs1490547221,2
    --63636735(+) TGAGCA/GAACTA 1 -- us2k10--------
    rs117115161,2
    C,F,H--63636777(+) TCTCAC/GTCATA 1 -- us2k15Minor allele frequency- G:0.44NA CSA 9
    rs751413621,2
    F--63636872(+) GAGGGG/ATAGCA 1 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for SNTN (63638344 - 63664696 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SNTN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422509CNV Deletion17116639
    nsv3849CNV Insertion18451855
    nsv460581CNV Loss19166990
    nsv834716CNV Loss17160897
    nsv876886CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with SNTN           About GenesLikeMe

    Genetic Association Database (GAD): SNTN

    Export disorders for SNTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNTN gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SNTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sentan: a novel specific component of the apical structure of vertebrate motile cilia. (PubMed id 18829862)1, 2, 3 Kubo A.... Amagai M. (Mol. Biol. Cell 2008)
    2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    3. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    4. Transcriptional gene expression profile of human nasopharynx. (PubMed id 15289893)2 Liu X.-Q....Zeng Y.-X. (Int. J. Mol. Med. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 132203 HGNC: 33706 AceView: LOC132203 Ensembl:ENSG00000188817 euGenes: HUgn132203
    ECgene: SNTN H-InvDB: SNTN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNTN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNTN gene:
    Search GeneIP for patents involving SNTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     genOway: Develop your customized and physiologically relevant rodent model for SNTN
      Search antibodies-online for antibodies for SNTN
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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