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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNTN Gene

protein-coding   GIFtS: 37
GCID: GC03P063616

Sentan, Cilia Apical Structure Protein

  Search for SNTN
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sentan, Cilia Apical Structure Protein1 2     sentan2
S100A-Like Protein1 2     Protein S100-A1-Like3
S100A1L2 3     S100 Calcium-Binding Protein A1-Like3
S100AL2     

External Ids:    HGNC: 337061   Entrez Gene: 1322032   Ensembl: ENSG000001888177   UniProtKB: A6NMZ23   

Export aliases for SNTN gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SNTN Gene: 
SNTN (sentan, cilia apical structure protein) is a protein-coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot: SNTAN_HUMAN, A6NMZ2
Function: May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet
microtubules (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNTN gene promoter:
         AP-2rep   HOXA9   HOXA9B   CUTL1   S8   FOXO1a   Meis-1a   LyF-1   Meis-1   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.2   Ensembl cytogenetic band:  3p14.2   HGNC cytogenetic band: 3p14.2

SNTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNTN gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P063616:  view genomic region     (about GC identifiers)

Start:
63,638,344 bp from pter      End:
63,664,696 bp from pter
Size:
26,353 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNTAN_HUMAN, A6NMZ2 (See protein sequence)
Recommended Name: Sentan  
Size: 147 amino acids; 16468 Da
Subcellular location: Cell projection, cilium (By similarity). Note=Expressed exclusively at the cilium tip where
it localizes between the cell membrane and peripheral A-subfibers (By similarity)
Miscellaneous: 'Sentan' means 'tip' in Japanese
Secondary accessions: B7FF65

Explore the universe of human proteins at neXtProt for SNTN: NX_A6NMZ2

SNTN Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001074006.1  
ENSEMBL proteins: 
 ENSP00000341442   ENSP00000420078   ENSP00000419971  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005929cilium IEA--

SNTN for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro protein domains:
 IPR011992 EF-hand-like_dom
 IPR026790 Sentan

Graphical View of Domain Structure for InterPro Entry A6NMZ2

ProtoNet protein and cluster: A6NMZ2

UniProtKB/Swiss-Prot: SNTAN_HUMAN, A6NMZ2
Similarity: Belongs to the S-100 family


SNTN for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SNTAN_HUMAN, A6NMZ2
Function: May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet
microtubules (By similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005509calcium ion binding IEA--
     
SNTN for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNTN

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SNTN (SNTAN)

Search CenterWatch for drugs/clinical trials and news about SNTN / SNTAN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SNTN gene: 
NM_001080537.1  

Unigene Cluster for SNTN:

Sentan, cilia apical structure protein
Hs.130704  [show with all ESTs]
Unigene Representative Sequence: AK126350
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000343837(uc003dlr.3) ENST00000469440 ENST00000496807
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Additional mRNA sequence: AK126350.1 

5 DOTS entries:

DT.402975  DT.120863585  DT.101975414  DT.120863558  DT.100735586 

24/49 AceView cDNA sequences (see all 49):

AI221311 BQ879653 AI687452 AA906188 AA359824 BU101660 BG547093 BI771256 
BM979832 AI683666 AW513603 BG534032 BV188688 BM978728 BX283104 AK126350 
BG542228 AA927213 BU679212 BG483873 BM969265 CD696773 CD685391 CD700315 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SNTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCGGCCAGGC
SNTN Expression
About this image


Genevestigator expression for SNTN

SOURCE GeneReport for Unigene cluster: Hs.130704
    SABiosciences Custom PCR Arrays for SNTN
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SNTN gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sntn1 , 5 sentan, cilia apical structure protein1, 5 82.99(n)1
72.11(a)1
  14 (6.93 cM)5
2187391  NM_177624.31  NP_808292.11 
 136708765 
chicken
(Gallus gallus)
Aves SNTN1 sentan, cilia apical structure protein 65.36(n)
60.94(a)
  416076  NM_001142847.1  NP_001136319.1 
lizard
(Anolis carolinensis)
Reptilia SNTN6
Uncharacterized protein
55(a)
1 ↔ 1
GL343210.1(2126163-2137004)


ENSEMBL Gene Tree for SNTN (if available)
TreeFam Gene Tree for SNTN (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SNTN gene
1 SIMAP similar gene for SNTN using alignment to 3 protein entries:     SNTAN_HUMAN (see all proteins):
S100A1

SNTN for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/345 SNPs in SNTN are shown (see all 345)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1419038111,2
--63636368(+) GGATGC/TGGAGA 1 -- us2k10--------
rs1870072021,2
--63636413(+) AAATTC/TGTTCA 1 -- us2k10--------
rs1915798411,2
--63636553(+) ACGTAC/TGTTTA 1 -- us2k10--------
rs1477724111,2
--63636576(+) TCACAA/GTAGCA 1 -- us2k10--------
rs130855101,2
F--63636581(+) atagcA/Caatac 1 -- us2k12Minor allele frequency- C:0.25NA 4
rs130855131,2
F--63636582(+) tagcaA/Gatact 1 -- us2k12Minor allele frequency- G:0.25NA 4
rs130855191,2
C,F--63636596(+) aaccaA/Ccctaa 1 -- us2k14Minor allele frequency- C:0.43NA CSA 7
rs1490547221,2
--63636735(+) TGAGCA/GAACTA 1 -- us2k10--------
rs117115161,2
C,F,H--63636777(+) TCTCAC/GTCATA 1 -- us2k15Minor allele frequency- G:0.44NA CSA 9
rs751413621,2
F--63636872(+) GAGGGG/ATAGCA 1 -- us2k11Minor allele frequency- A:0.50NA 2

HapMap Linkage Disequilibrium report for SNTN (63638344 - 63664696 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for SNTN:    About this table     
Variant IDTypeSubtypePubMed ID
esv2422509CNV Deletion17116639
nsv3849CNV Insertion18451855
nsv460581CNV Loss19166990
nsv834716CNV Loss17160897
nsv876886CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SNTN for disorders           About MalaCards

SNTN for disorders           About GeneDecksing

Genetic Association Database (GAD): SNTN

Export disorders for SNTN gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SNTN gene integrated from 9 sources:
(articles sorted by number of sources associating them with SNTN)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Sentan: a novel specific component of the apical structure of vertebrate motile cilia. (PubMed id 18829862)1, 2, 3 Kubo A.... Amagai M. (2008)
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
  3. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)
  4. Transcriptional gene expression profile of human nasopharynx. (PubMed id 15289893)2 Liu X.-Q....Zeng Y.-X. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 132203 HGNC: 33706 AceView: LOC132203 Ensembl:ENSG00000188817 euGenes: HUgn132203
ECgene: SNTN H-InvDB: SNTN

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SNTN Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SNTN gene:
Search GeneIP for patents involving SNTN

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 CLIAs for SNTN
 Search LifeMap BioReagents cell lines for SNTN
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNTN
 Browse SwitchGear 3'UTR luciferase reporter plasmids for SNTN
 Browse SwitchGear Promoter luciferase reporter plasmids for SNTN
 Search ThermoFisher Antibodies for SNTN
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SNTN
 inGenious Targeting Laboratory - Custom generated mouse model solutions for SNTN
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SNTN
Customized:
 lentivirus for stable overexpression of SNTN
 lentivirus expression plasmids for stable overexpression of SNTN
 adenovirus for overexpression of SNTN
 Search LSBio for Antibodies for SNTN
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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