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Aliases for SNTN Gene

Aliases for SNTN Gene

  • Sentan, Cilia Apical Structure Protein 2 3 5
  • S100A-Like Protein 2 3
  • S100A1L 3 4
  • S100 Calcium-Binding Protein A1-Like 4
  • Protein S100-A1-Like 4
  • S100AL 3
  • Sentan 3

External Ids for SNTN Gene

Summaries for SNTN Gene

GeneCards Summary for SNTN Gene

SNTN (Sentan, Cilia Apical Structure Protein) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot for SNTN Gene

  • May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNTN Gene

Genomics for SNTN Gene

Regulatory Elements for SNTN Gene

Enhancers for SNTN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F063624 0.8 Ensembl ENCODE 11.1 -27.2 -27171 1.4 JUND JUN GATAD2B REST MYC ZNF18 SNTN SYNPR-AS1 RNA5SP134
GH03F063687 0.8 VISTA 11 +35.5 35464 2.0 SREBF1 MTA3 RFX1 HSF1 ZBTB40 EZH2 PSMD6-AS2 SNTN SYNPR-AS1 RNA5SP134 C3orf49 ENSG00000243410 LOC105377119
GH03F063576 0.8 ENCODE 10.6 -75.3 -75263 2.0 GTF2F1 CEBPG RAD21 GATA3 CTBP1 MTA3 RCOR1 FOS EZH2 TCF7L2 SYNPR-AS1 RNA5SP134 SNTN C3orf49 SYNPR
GH03F063673 0.2 ENCODE 12 +20.6 20632 0.2 SNTN LOC105377119
GH03F063654 0.5 ENCODE 0.8 +3.4 3422 2.8 CTCF JUND EZH2 SYNPR-AS1 SNTN LOC105377119
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNTN on UCSC Golden Path with GeneCards custom track

Genomic Location for SNTN Gene

63,652,668 bp from pter
63,679,020 bp from pter
26,353 bases
Plus strand

Genomic View for SNTN Gene

Genes around SNTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNTN Gene

Proteins for SNTN Gene

  • Protein details for SNTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B7FF65

    Protein attributes for SNTN Gene

    147 amino acids
    Molecular mass:
    16468 Da
    Quaternary structure:
    No Data Available
    • Sentan means tip in Japanese.

neXtProt entry for SNTN Gene

Post-translational modifications for SNTN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNTN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNTN Gene

Domains & Families for SNTN Gene

Protein Domains for SNTN Gene

Suggested Antigen Peptide Sequences for SNTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the S-100 family.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with SNTN: view

No data available for Gene Families for SNTN Gene

Function for SNTN Gene

Molecular function for SNTN Gene

UniProtKB/Swiss-Prot Function:
May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.

Phenotypes for SNTN Gene

genes like me logo Genes that share phenotypes with SNTN: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNTN Gene

Localization for SNTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNTN Gene

Cell projection, cilium. Note=Expressed exclusively at the cilium tip where it localizes between the cell membrane and peripheral A-subfibers. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNTN gene
Compartment Confidence
cytosol 3
plasma membrane 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SNTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with SNTN: view

Pathways & Interactions for SNTN Gene

No Data Available

Interacting Proteins for SNTN Gene

Gene Ontology (GO) - Biological Process for SNTN Gene


No data available for Pathways by source and SIGNOR curated interactions for SNTN Gene

Transcripts for SNTN Gene

mRNA/cDNA for SNTN Gene

Unigene Clusters for SNTN Gene

Sentan, cilia apical structure protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNTN Gene

No ASD Table

Relevant External Links for SNTN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNTN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNTN Gene

mRNA differential expression in normal tissues according to GTEx for SNTN Gene

This gene is overexpressed in Fallopian Tube (x21.2), Cervix - Endocervix (x16.0), and Lung (x11.6).

NURSA nuclear receptor signaling pathways regulating expression of SNTN Gene:


SOURCE GeneReport for Unigene cluster for SNTN Gene:

genes like me logo Genes that share expression patterns with SNTN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SNTN Gene

Orthologs for SNTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNTN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNTN 34 35
  • 99.32 (n)
(Canis familiaris)
Mammalia SNTN 34 35
  • 86.85 (n)
(Bos Taurus)
Mammalia SNTN 34 35
  • 85.71 (n)
(Mus musculus)
Mammalia Sntn 34 16 35
  • 82.99 (n)
(Rattus norvegicus)
Mammalia Sntn 34
  • 82.05 (n)
(Monodelphis domestica)
Mammalia SNTN 35
  • 67 (a)
(Gallus gallus)
Aves SNTN 34 35
  • 62.73 (n)
(Anolis carolinensis)
Reptilia SNTN 35
  • 55 (a)
Species where no ortholog for SNTN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNTN Gene

Gene Tree for SNTN (if available)
Gene Tree for SNTN (if available)

Paralogs for SNTN Gene

(1) SIMAP similar genes for SNTN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SNTN: view

No data available for Paralogs for SNTN Gene

Variants for SNTN Gene

Sequence variations from dbSNP and Humsavar for SNTN Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1039078 -- 63,662,290(+) TGTTG(C/T)GTCCC intron-variant
rs10510909 -- 63,655,054(-) AGAAC(A/G)CTGAA intron-variant
rs11130954 -- 63,657,368(+) CACTT(A/G)GCCCT intron-variant
rs111343679 -- 63,663,967(+) GAGAG(A/G)TCCTT reference, missense
rs111521188 -- 63,652,507(+) ACAGT(A/G)CCATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNTN Gene

Variant ID Type Subtype PubMed ID
esv2422509 CNV deletion 17116639
nsv1008751 CNV gain 25217958
nsv3849 CNV insertion 18451855
nsv460581 CNV loss 19166990
nsv590459 CNV loss 21841781
nsv834716 CNV loss 17160897

Variation tolerance for SNTN Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNTN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNTN Gene

Disorders for SNTN Gene

Relevant External Links for SNTN

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SNTN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNTN Gene

Publications for SNTN Gene

  1. Sentan: a novel specific component of the apical structure of vertebrate motile cilia. (PMID: 18829862) Kubo A. … Amagai M. (Mol. Biol. Cell 2008) 2 3 4 64
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64
  3. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 46 64
  4. Transcriptional gene expression profile of human nasopharynx. (PMID: 15289893) Liu X.-Q. … Zeng Y.-X. (Int. J. Mol. Med. 2004) 4 64

Products for SNTN Gene

Sources for SNTN Gene

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