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Aliases for SNTG2 Gene

Aliases for SNTG2 Gene

  • Syntrophin, Gamma 2 2 3
  • Syntrophin-5 3 4
  • G2SYN 3 4
  • SYN5 3 4
  • Gamma-2-Syntrophin 3

External Ids for SNTG2 Gene

Summaries for SNTG2 Gene

Entrez Gene Summary for SNTG2 Gene

  • This gene encodes a protein belonging to the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain of dystrophin and dystrophin-related proteins. The PDZ domain of this protein product interacts with a protein component of a mechanosensitive sodium channel that affects channel gating. Absence or reduction of this protein product has been associated with Duchenne muscular dystrophy. There is evidence of alternative splicing yet the full-length nature of these variants has not been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNTG2 Gene

SNTG2 (Syntrophin, Gamma 2) is a Protein Coding gene. Diseases associated with SNTG2 include duchenne muscular dystrophy. GO annotations related to this gene include phospholipid binding and PDZ domain binding. An important paralog of this gene is SNTG1.

UniProtKB/Swiss-Prot for SNTG2 Gene

  • Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNTG2 Gene

Genomics for SNTG2 Gene

Genomic Location for SNTG2 Gene

Start:
950,868 bp from pter
End:
1,367,629 bp from pter
Size:
416,762 bases
Orientation:
Plus strand

Genomic View for SNTG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNTG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNTG2 Gene

Regulatory Elements for SNTG2 Gene

Proteins for SNTG2 Gene

  • Protein details for SNTG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY99-SNTG2_HUMAN
    Recommended name:
    Gamma-2-syntrophin
    Protein Accession:
    Q9NY99
    Secondary Accessions:
    • Q05AH5

    Protein attributes for SNTG2 Gene

    Size:
    539 amino acids
    Molecular mass:
    60217 Da
    Quaternary structure:
    • Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB.

    Alternative splice isoforms for SNTG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNTG2 Gene

Proteomics data for SNTG2 Gene at MOPED

Post-translational modifications for SNTG2 Gene

No Post-translational modifications

Other Protein References for SNTG2 Gene

No data available for DME Specific Peptides for SNTG2 Gene

Domains for SNTG2 Gene

Protein Domains for SNTG2 Gene

Suggested Antigen Peptide Sequences for SNTG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NY99

UniProtKB/Swiss-Prot:

SNTG2_HUMAN
Domain:
  • The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.:
    • Q9NY99
  • Contains 1 PDZ (DHR) domain.:
    • Q9NY99
  • Contains 1 PH domain.:
    • Q9NY99
Family:
  • Belongs to the syntrophin family.:
    • Q9NY99
genes like me logo Genes that share domains with SNTG2: view

No data available for Gene Families for SNTG2 Gene

Function for SNTG2 Gene

Molecular function for SNTG2 Gene

UniProtKB/Swiss-Prot Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).

Gene Ontology (GO) - Molecular Function for SNTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
GO:0030165 PDZ domain binding IPI 17292328
genes like me logo Genes that share ontologies with SNTG2: view

miRNA for SNTG2 Gene

miRTarBase miRNAs that target SNTG2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNTG2 Gene

Localization for SNTG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNTG2 Gene

Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNTG2 Gene COMPARTMENTS Subcellular localization image for SNTG2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SNTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0016013 syntrophin complex TAS 10747910
GO:0042383 sarcolemma IEA --
genes like me logo Genes that share ontologies with SNTG2: view

Pathways for SNTG2 Gene

SuperPathways for SNTG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development TAS 10747910
genes like me logo Genes that share ontologies with SNTG2: view

No data available for Pathways by source for SNTG2 Gene

Transcripts for SNTG2 Gene

Unigene Clusters for SNTG2 Gene

Syntrophin, gamma 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNTG2 Gene

No ASD Table

Relevant External Links for SNTG2 Gene

GeneLoc Exon Structure for
SNTG2
ECgene alternative splicing isoforms for
SNTG2

Expression for SNTG2 Gene

mRNA expression in normal human tissues for SNTG2 Gene

mRNA differential expression in normal tissues according to GTEx for SNTG2 Gene

This gene is overexpressed in Testis (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SNTG2 Gene

SOURCE GeneReport for Unigene cluster for SNTG2 Gene Hs.595069

mRNA Expression by UniProt/SwissProt for SNTG2 Gene

Q9NY99-SNTG2_HUMAN
Tissue specificity: Widely expressed. Strong expression in brain and testis. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia.
genes like me logo Genes that share expressions with SNTG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SNTG2 Gene

Orthologs for SNTG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNTG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNTG2 35
  • 99.14 (n)
  • 98.6 (a)
SNTG2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNTG2 35
  • 79.49 (n)
  • 75.65 (a)
SNTG2 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sntg2 35
  • 82.68 (n)
  • 83.12 (a)
Sntg2 16
Sntg2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNTG2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNTG2 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sntg2 35
  • 79.8 (n)
  • 79.87 (a)
chicken
(Gallus gallus)
Aves SNTG2 35
  • 78.48 (n)
  • 83.12 (a)
SNTG2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNTG2 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sntg2 35
  • 70.56 (n)
  • 73.45 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC569320 35
  • 66.41 (n)
  • 65.84 (a)
sntg2 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Syn2 36
  • 37 (a)
OneToMany
Syn2 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea stn-2 36
  • 31 (a)
OneToMany
F27D9.8 37
  • 31 (a)
Species with no ortholog for SNTG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNTG2 Gene

ENSEMBL:
Gene Tree for SNTG2 (if available)
TreeFam:
Gene Tree for SNTG2 (if available)

Paralogs for SNTG2 Gene

Paralogs for SNTG2 Gene

Selected SIMAP similar genes for SNTG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNTG2: view

Variants for SNTG2 Gene

Sequence variations from dbSNP and Humsavar for SNTG2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1106214 -- 1,351,624(-) GATGA(C/G)AACAG intron-variant
rs2068487 -- 1,142,425(-) CATGG(C/T)ACTGG intron-variant
rs2068693 -- 1,142,492(-) AAAAC(A/C)CTAAG intron-variant
rs2068694 -- 1,142,463(-) CCCAG(A/G)AACTC intron-variant
rs2068695 -- 1,142,398(-) AGGTG(A/G)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNTG2 Gene

Variant ID Type Subtype PubMed ID
dgv4036n71 CNV Gain 21882294
esv2422306 CNV Duplication 17116639
nsv468883 CNV Gain 19166990
nsv873554 CNV Loss 21882294
nsv468905 CNV Loss 19166990
nsv508768 CNV Insertion 20534489
nsv827908 CNV Gain 20364138
esv2188360 CNV Deletion 18987734
esv2719156 CNV Deletion 23290073
esv2719157 CNV Deletion 23290073
nsv827920 CNV Gain 20364138
esv2657110 CNV Deletion 23128226
nsv214107 CNV Loss 16902084
esv2719158 CNV Deletion 23290073
esv4011 CNV Deletion 18987735
nsv873557 CNV Gain 21882294
esv2556327 CNV Deletion 19546169
nsv821278 CNV Deletion 20802225
esv26963 CNV Gain 19812545
nsv511756 CNV Loss 21212237
esv1177146 CNV Deletion 17803354
esv1182776 CNV Deletion 17803354
esv1420311 CNV Deletion 17803354
esv1684264 CNV Deletion 17803354
esv2719159 CNV Deletion 23290073
esv2719160 CNV Deletion 23290073
esv2664944 CNV Deletion 23128226
esv2719161 CNV Deletion 23290073
esv2750739 CNV Loss 17666407
esv2719163 CNV Deletion 23290073
esv1785618 CNV Deletion 17803354
esv2719164 CNV Deletion 23290073
esv2594417 CNV Deletion 19546169
esv2719165 CNV Deletion 23290073
esv2021015 CNV Deletion 18987734
esv2719166 CNV Deletion 23290073
esv4971 CNV Deletion 18987735
dgv590e201 CNV Deletion 23290073
dgv591e201 CNV Deletion 23290073
nsv820761 CNV Deletion 20802225
esv25805 CNV Gain+Loss 19812545
dgv592e201 CNV Deletion 23290073
esv2719174 CNV Deletion 23290073
dgv593e201 CNV Deletion 23290073
esv1006304 CNV Deletion 20482838
esv2719179 CNV Deletion 23290073
esv5053 CNV Deletion 18987735
esv2664385 CNV Deletion 23128226
dgv594e201 CNV Deletion 23290073
esv2719181 CNV Deletion 23290073
esv1772570 CNV Deletion 17803354
esv2676817 CNV Deletion 23128226
esv2719183 CNV Deletion 23290073
esv2742400 CNV Deletion 23290073
esv2741208 CNV Deletion 23290073
dgv595e201 CNV Deletion 23290073
dgv596e201 CNV Deletion 23290073
esv2719189 CNV Deletion 23290073
esv2491095 CNV Loss 19546169
esv23155 CNV Loss 19812545
esv29923 CNV Loss 19812545
esv27993 CNV Gain 19812545
esv267937 CNV Insertion 20981092
esv1729282 CNV Insertion 17803354
esv2660845 CNV Deletion 23128226
esv275045 CNV Loss 21479260
esv272138 CNV Insertion 20981092
esv273601 CNV Insertion 20981092
nsv2565 CNV Insertion 18451855
nsv508779 CNV Insertion 20534489
esv2719193 CNV Deletion 23290073
nsv873558 CNV Loss 21882294
esv27414 CNV Gain+Loss 19812545
esv2677764 CNV Deletion 23128226
esv2719194 CNV Deletion 23290073
dgv671e199 CNV Deletion 23128226
dgv672e199 CNV Deletion 23128226
esv2719196 CNV Deletion 23290073
esv1295552 CNV Insertion 17803354
esv2662673 CNV Deletion 23128226
esv1277876 CNV Insertion 17803354
nsv821574 CNV Deletion 20802225
esv989870 CNV Gain 20482838
esv1548787 CNV Insertion 17803354
esv2719197 CNV Deletion 23290073
esv2719198 CNV Deletion 23290073
esv2719199 CNV Deletion 23290073
esv2719200 CNV Deletion 23290073
nsv215334 CNV Insertion 16902084
esv2719201 CNV Deletion 23290073
esv2719202 CNV Deletion 23290073
esv2455698 CNV Insertion 19546169
nsv873559 CNV Gain 21882294
esv2719203 CNV Deletion 23290073
esv2719204 CNV Deletion 23290073
nsv511757 CNV Loss 21212237
esv27230 CNV Loss 19812545
esv1922088 CNV Deletion 18987734
esv2719205 CNV Deletion 23290073
esv2719207 CNV Deletion 23290073
esv2719208 CNV Deletion 23290073
esv1939838 CNV Deletion 18987734
esv2719209 CNV Deletion 23290073
esv2719210 CNV Deletion 23290073
esv2719211 CNV Deletion 23290073
nsv820345 CNV Deletion 20802225
nsv511758 CNV Loss 21212237
esv23636 CNV Gain+Loss 19812545
nsv514980 CNV Complex 21397061
dgv597e201 CNV Deletion 23290073
esv2719213 CNV Deletion 23290073
esv2719215 CNV Deletion 23290073
nsv214978 CNV Loss 16902084
esv2719216 CNV Deletion 23290073
esv2719218 CNV Deletion 23290073
esv2719219 CNV Deletion 23290073
esv2719220 CNV Deletion 23290073
nsv511759 CNV Loss 21212237
esv2571201 CNV Deletion 19546169
esv2024635 CNV Deletion 18987734
esv2273265 CNV Deletion 18987734
esv5074 CNV Deletion 18987735
nsv215284 CNV Loss 16902084
esv1000564 CNV Deletion 20482838
esv8388 CNV Loss 19470904
dgv598e201 CNV Deletion 23290073
dgv599e201 CNV Deletion 23290073
esv2742346 CNV Deletion 23290073
esv27633 CNV Loss 19812545
esv2719226 CNV Deletion 23290073
esv1005044 CNV Loss 20482838
esv2719227 CNV Deletion 23290073
esv2719229 CNV Deletion 23290073
esv2719230 CNV Deletion 23290073
esv2719231 CNV Deletion 23290073
esv2719232 CNV Deletion 23290073
esv2719233 CNV Deletion 23290073

Relevant External Links for SNTG2 Gene

HapMap Linkage Disequilibrium report
SNTG2
Human Gene Mutation Database (HGMD)
SNTG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNTG2 Gene

Disorders for SNTG2 Gene

Relevant External Links for SNTG2

Genetic Association Database (GAD)
SNTG2
genes like me logo Genes that share disorders with SNTG2: view

No data available for UniProtKB/Swiss-Prot for SNTG2 Gene

Publications for SNTG2 Gene

  1. Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells. (PMID: 10747910) Piluso G. … Nigro V. (J. Biol. Chem. 2000) 2 3 4 23
  2. Syntrophin gamma 2 regulates SCN5A gating by a PDZ domain-mediated interaction. (PMID: 12429735) Ou Y. … Farrugia G. (J. Biol. Chem. 2003) 3 23
  3. Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations. (PMID: 17292328) Yamakawa H. … Ishiura S. (Biochem. Biophys. Res. Commun. 2007) 3 23
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SNTG2 Gene

Sources for SNTG2 Gene

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