SNTG2 Gene
protein-coding GIFtS: 49
GCID: GC02P000942
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syntrophin, gamma 2
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Aliases for SNTG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Syntrophin, Gamma 21 2 | | G2SYN1 2 3 | | SYN51 2 3 | | Gamma-2-Syntrophin1 | | Syntrophin-53 | | Syntrophin-53 |
Export aliases for SNTG2 gene to outside databasesPrevious GC identifers: GC02P001386 GC02P9B0036 |
Summaries for SNTG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for SNTG2: This gene encodes a protein belonging to the syntrophin family. Syntrophins are cytoplasmic peripheral membraneproteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain ofdystrophin and dystrophin-related proteins. The PDZ domain of this protein product interacts with a protein componentof a mechanosensitive sodium channel that affects channel gating. Absence or reduction of this protein product hasbeen associated with Duchenne muscular dystrophy. There is evidence of alternative splicing yet the full-length natureof these variants has not been described. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: SNTG2_HUMAN, Q9NY99Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins.May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity)
|
Genomic Views for SNTG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022221.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SNTG2 gene promoter: Pbx1a HOXA3 NCX/Ncx CUTL1 STAT5A AP-2beta AP-2alpha En-1 RSRFC4 AP-2alphaA Other transcription factors
Search SABiosciences Chromatin IP Primers for SNTG2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNTG2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p25.3 Ensembl cytogenetic band: 2p25.3 HGNC cytogenetic band: 2p25SNTG2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P000942: view genomic region
(about GC identifiers)
Start:
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946,554 bp from pter |
End:
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1,371,385 bp from pter |
Size:
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424,832 bases |
Orientation:
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plus strand |
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Proteins for SNTG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SNTG2_HUMAN, Q9NY99 (See
protein sequence)Recommended Name: Gamma-2-syntrophin Size: 539 amino acids; 60217 Da
Subunit: Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB
Subcellular location: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm,cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane
Secondary accessions: Q05AH5Alternative splicing: 2 isoforms: Q9NY99-1 Q9NY99-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SNTG2: NX_Q9NY99
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NY99 SNTG2 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_061841.2 ENSEMBL proteins: ENSP00000412249 ENSP00000401997 ENSP00000311837 ENSP00000385020 Human Recombinant Protein Products for SNTG2:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SNTG2 for ontologies About GeneDecksing
SNTG2 Antibody Products: Assay Products for SNTG2: |
Protein
Domains / Families for SNTG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNTG2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NY99ProtoNet protein and cluster: Q9NY99 2 Blocks protein families: IPB001478 PDZ/DHR/GLGF domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: SNTG2_HUMAN, Q9NY99Domain: The association with dystrophin or related proteins probably leaves the PDZ domain available to recruitproteins to the membrane (By similarity)Similarity: Belongs to the syntrophin familySimilarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 1 PH domain |
Function for SNTG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: SNTG2_HUMAN, Q9NY99Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins.May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity) Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
SNTG2 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNTG2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNTG2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNTG2 |
|
Pathways & Interactions for SNTG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNTG2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
 5/23 Interacting proteins for SNTG2 (Q9NY992, 3 ENSP000003118374) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007417 | central nervous system development |
TAS | 10747910 |
SNTG2 for ontologies About GeneDecksing
|
Drugs & Compounds for SNTG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SNTG2 Search CenterWatch for drugs/clinical trials and news about SNTG2 
|
Transcripts for SNTG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SNTG2 gene: NM_018968.3 Unigene Cluster for SNTG2: Syntrophin, gamma 2 Hs.595069 [show with all ESTs]Unigene Representative Sequence: AJ00302912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000452177(uc002qwp.3) ENST00000450962 ENST00000308624(uc002qwq.3 uc010ewi.3) ENST00000407292 ENST00000463442 ENST00000475201 ENST00000467759 ENST00000494178 ENST00000498321 ENST00000489646 ENST00000471239 ENST00000472606
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNTG2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNTG2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SNTG2 (NM_018968) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNTG2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNTG2  |
Additional cDNA sequence: AJ003029.1 BC035783.1 BC125251.1 7 DOTS entries: DT.304379 DT.91757858 DT.120969319 DT.92068091 DT.97782001 DT.75143463 DT.86845886 18 AceView cDNA sequences: BE044431 BM543795 AA405742 BV200947 AW592765 BP368994 AI393344 BC035783 AA405993 BG216682 Z43606 BG184880 BG204508 BG209790 NM_018968 AJ003029 BG216683 AA448072 GeneLoc Exon Structure
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Expression for SNTG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNTG2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TCACTAGTTT
 About this image See SNTG2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SNTG2
SOURCE GeneReport for Unigene cluster: Hs.595069
UniProtKB/Swiss-Prot: SNTG2_HUMAN, Q9NY99Tissue specificity: Widely expressed. Strong expression in brain and testis. In CNS, it is expressed in the perikaryonand proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granulecells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellarcortex, deep cerebellar nuclei, thalamus, and basal ganglia SABiosciences Custom PCR Arrays for SNTG2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNTG2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNTG2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNTG2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNTG2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNTG2 |
Orthologs for SNTG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNTG2 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
SNTG21 |
syntrophin, gamma 2 |
79.39(n) 84.69(a) |
  |
421913 XM_419930.3 XP_419930.3 |
lizard (Anolis carolinensis) |
Reptilia |
SNTG26SNTA16(see all 4) |
-- |
82(a)19(a)(see all 4) |
1 ↔ 1possible ortholog(see all 4) |
1(160920974-161150312) 4(136242444-136252823) |
zebrafish (Danio rerio) |
Actinopterygii |
LOC5693201 |
novel protein similar to vertebrate syntrophin, gamma more |
66.41(n) 65.84(a) |
  |
569320 NM_001126427.1 NP_001119899.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
Syn23 |
cytoskeletal protein binding |
35(a) |
  |
53C7 -- |
worm (Caenorhabditis elegans) |
Secernentea |
F27D9.83 |
synapse-associated protein |
31(a) |
  |
X(7711659-7713932) -- |
ENSEMBL Gene Tree for SNTG2 (if available) TreeFam Gene Tree for SNTG2 (if available)  |
Paralogs for SNTG2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SNTG2 gene
- SNTG12 SNTA12 SNTB12 SNTB22
2 SIMAP similar genes for SNTG2 using alignment to 2 protein entries: SNTG2_HUMAN (see all proteins):SNTG1 DLG4
SNTG2 for paralogs About GeneDecksing
|
Genomic Variants for SNTG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SNTG2 (946554 - 1196554 bp, first 250kb of SNTG2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 42 variations for SNTG2 15/25 CNVs (see all 25): 35716 71993 71961 89374 78329 97734 97731 23578 43279 5206 72224 5964 97732 72176 66715 15/17 Indels (see all 17): 45861 45860 78328 43127 61736 43061 26769 42241 26398 89372 26768 45836 45854 89373 78327 Human Gene Mutation Database (HGMD): SNTG2
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNTG2 |
|
Disorders
/ Diseases for SNTG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNTG2 for disorders About GeneDecksing
OMIM gene information: 608715
OMIM disorders: --
4 diseases for SNTG2: About MalaCardsduchenne muscular dystrophy muscular dystrophy cerebritis neuronitis Export disorders for SNTG2 gene to outside databases
|
Publications for SNTG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNTG2 gene integrated from 9 sources: (articles sorted by number of sources associating them with SNTG2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells. (PubMed id 10747910)1, 2, 3, 9 Piluso G.... Nigro V. (2000)
- Syntrophin gamma 2 regulates SCN5A gating by a PDZ domain-mediated interaction. (PubMed id 12429735)1, 9 Ou Y....Farrugia G. (2003)
- Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations. (PubMed id 17292328)1, 9 Yamakawa H....Ishiura S. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
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External Searches for SNTG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SNTG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNTG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNTG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SNTG2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNTG2 gene: Search GeneIP for patents involving SNTG2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SNTG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
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 | |
 | |
 |
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